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https://www.readbyqxmd.com/read/28241491/complexing-methylene-blue-with-phosphorus-dendrimers-to-increase-photodynamic-activity
#1
Monika Dabrzalska, Anna Janaszewska, Maria Zablocka, Serge Mignani, Jean Pierre Majoral, Barbara Klajnert-Maculewicz
The efficiency of photodynamic therapy is limited mainly due to low selectivity, unfavorable biodistribution of photosensitizers, and long-lasting skin sensitivity to light. However, drug delivery systems based on nanoparticles may overcome the limitations mentioned above. Among others, dendrimers are particularly attractive as carriers, because of their globular architecture and high loading capacity. The goal of the study was to check whether an anionic phosphorus dendrimer is suitable as a carrier of a photosensitizer-methylene blue (MB)...
February 23, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28240756/assessment-and-therapeutic-choice-in-septic-arthritis-of-the-hip-in-an-intravenous-drug-abuser-case-report-at-14-years-follow-up-and-review-of-literature
#2
P Persiani, F M Ranaldi, O Mazza, A Calistri, M Bove, M Crostelli, C Villani
INTRODUCTION: Osteoarticular infections are found frequently in drug addicted individuals, representing one of the main reasons for their hospitalization. Through inoculation, the pathogenic agents can enter the individual's system directly through the skin or parenterally, transmitted, that is, through syringes and other objects used during such practice. In these particular conditions, or when the medical history is vague, a warranted suspicion and the execution of targeted research can help in the diagnosis of high-risk patients such as addicts...
January 2017: La Clinica Terapeutica
https://www.readbyqxmd.com/read/28240013/assessment-of-physical-therapy-strategies-for-recovery-of-urinary-continence-after-prostatectomy
#3
Nivea Adriano de Santana Santos, Maria Vieira de Lima Saintrain, Rommel Prata Regadas, Romulo Augusto da Silveira, Francisco Julimar Correia de Menezes
Introduction: Urinary incontinence is a complication of radical prostatectomy. Pelvic floor exercises can facilitate recovery of continence after surgery; however, there is not sufficient evidence that physical therapy with biofeedback training is effective, particularly with respect to providing a faster recovery. Objective: To analyze the application of physical therapy techniques in the recovery of urinary incontinence after prostatectomy. Methodology: A randomized clinical trial was conducted from April to October 2015 with patients undergoing radical prostatectomy up to three months after surgery at the Santa Casa de Misericordia in Northeastern Brazil...
1, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/28239951/the-technical-efficiency-of-oral-healthcare-provision-evaluating-role-substitution-in-national-health-service-dental-practices-in-england
#4
Harry Hill, Stephen Birch, Martin Tickle, Ruth McDonald, Paul Brocklehurst
OBJECTIVES: In many countries increasing use is being made of dental care professionals (DCPs) to provide aspects of clinical activity previously undertaken by dentists. This study evaluates the differences in practice efficiency associated with the utilisation of DCPs in the provision of General Dental Services in the National Health Service (NHS) in England. METHODS: One hundred twenty-one NHS practices completed a questionnaire and shared practice information held at the NHS Business Services Authority...
February 27, 2017: Community Dentistry and Oral Epidemiology
https://www.readbyqxmd.com/read/28239800/intermediate-cd14-cd16-monocyte-predicts-severe-coronary-stenosis-and-extensive-plaque-involvement-in-asymptomatic-individuals
#5
Shyh-Chyi Lo, Wen-Jeng Lee, Ching-Yi Chen, Bai-Chin Lee
Circulating leukocyte subtypes and monocyte subsets are independent predictors of cardiovascular events. We hypothesized that an increased leukocyte subtype would predict severe coronary stenosis and extensive plaque involvement. We retrospectively analyzed clinical, laboratory, and coronary CT data in a total of 588 asymptomatic adults (69% men; mean age, 57 ± 9 years) undergoing a general health check-up. Intermediate CD14(++)CD16(+) monocyte count had the strongest association with mixed and calcified plaque scores, whereas the numbers of neutrophils and classical CD14(++)CD16(-) monocytes were significantly associated with non-calcified plaque score...
February 26, 2017: International Journal of Cardiovascular Imaging
https://www.readbyqxmd.com/read/28238888/decrease-in-regulatory-t-cell-function-in-chronic-hepatitis-c-patients-receiving-pegylated-interferon-plus-ribavirin
#6
Kuo-Chih Tseng, Yun-Che Ho, Chi-Wei Tseng, Ling-Huei Tseng, Yu-Hsi Hsieh, Ting-Tsung Chang, Shu-Fen Wu
OBJECTIVES: Regulatory T cells (Tregs) play an important role in the pathogenesis of chronic hepatitis C (CHC) infection. Pegylated interferon is the standard therapy for CHC patients in Asian countries. This study aims to evaluate the frequency and function of Tregs in CHC patients receiving combination therapy. METHODS: CHC patients (n=30) who had elevated alanine aminotransferase and underwent combination therapy were included. Clinical data and Tregs function were checked at baseline, 12 weeks after treatment, end of treatment, and at the end of a 24-week follow-up...
February 23, 2017: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/28238706/an-extra-repabc-locus-in-the-incrh2-ti-plasmid-ptibo542-exerts-incompatibility-toward-an-incrh1-plasmid
#7
Shinji Yamamoto, Vita Agustina, Ayako Sakai, Kazuki Moriguchi, Katsunori Suzuki
Ti/Ri plasmids in pathogenic Agrobacterium species are repABC replicons that are stably maintained by the function of repABC genes. Two Ti plasmids, pTiBo542 and pTiS4, belonging to incRh2 and incRh4 incompatibility groups, respectively, were reported to carry two repABC loci. In the present study, to reveal the roles of the two repABC loci in the two plasmids, we constructed mini-replicons carrying any one or both of the repABC loci (referred to as repABC1 and repABC2 here) and examined their replication and incompatibility properties...
February 23, 2017: Plasmid
https://www.readbyqxmd.com/read/28238481/attitudes-and-counseling-practices-of-pediatricians-regarding-youth-sports-participation-and-concussion-risks
#8
Michael Fishman, Eleanor Taranto, Meryl Perlman, Kyran Quinlan, Holly J Benjamin, Lainie Friedman Ross
OBJECTIVE: To examine attitudes and practices of pediatricians toward sports-related head trauma and youth participation in tackle football and ice hockey. STUDY DESIGN: A respondent-anonymous electronic survey was distributed 3 times to members of the American Academy of Pediatrics Section of Bioethics, Council on Injury, Violence, and Poison Prevention, and Council on Sports Medicine and Fitness. RESULTS: Of 791 eligible pediatricians, 227 (29%) responded...
February 24, 2017: Journal of Pediatrics
https://www.readbyqxmd.com/read/28238212/development-a-rapid-and-accurate-multiplex-real-time-pcr-method-for-the-detection-chlamydia-trachomatis-and-mycoplasma-hominis
#9
Roya Safarkar, Jalil Fallah Mehrabadi, Zahra Noormohammadi, Reza Mirnejad
BACKGROUND: Sexually transmitted diseases easily spread among sexually active people and often have no symptoms. Rapid and accurate method for detecting these infections are necessary in early stages. The traditional detection methods of them are difficult and time-consuming. METHODS: In this study, multiplex real time PCR was optimized for rapid identification of Chlamydia trachomatis and Mycoplasma hominis in a single tube and was performed with our designed primers...
February 26, 2017: Journal of Clinical Laboratory Analysis
https://www.readbyqxmd.com/read/28237348/early-postpartum-administration-of-equine-chorionic-gonadotropin-to-dairy-cows-calved-during-the-hot-season-effects-on-fertility-after-first-artificial-insemination
#10
R Patron-Collantes, I Lopez-Helguera, J L Pesantez-Pacheco, F Sebastian, M Fernández, O Fargas, S Astiz
Heat stress reduces fertility of high-producing dairy cows, and early administration of equine chorionic gonadotropin (eCG) may improve it. Here, 401 heat-stressed, high-producing dairy cows on a single commercial farm were given eCG (500 UI, n = 214) or saline (n = 187) on days 11-17 after calving, and the effects on fertility after the first artificial insemination (AI) were assessed. On post-partum day 96.34 ± 9.88, all cows were inseminated after a "double short Cosynch" synchronization protocol...
April 1, 2017: Theriogenology
https://www.readbyqxmd.com/read/28237300/radiographer-workforce-role-expansion-to-improve-patient-safety-related-to-nasogastric-tube-placement-for-feeding-in-adults
#11
G Roe, K M Harris, H Lambie, D J M Tolan
AIM: To determine whether the active involvement of radiographers in nasogastric tube (NGT) management at a large multisite healthcare institution can contribute to risk reduction regarding feeding through misplaced NGTs. MATERIALS AND METHODS: Despite national guidance in the National Health Service advising on safe practice to confirm NGT position, a number of "never events" (feeding through misplaced NGT) continue to occur due to misinterpretation of the check radiograph...
February 22, 2017: Clinical Radiology
https://www.readbyqxmd.com/read/28237146/is-routine-histopathological-examination-of-dacryocystorhinostomy-dacryocystectomy-specimens-necessary-a-tertiary-eye-hospital-experience
#12
Hind Alkatan, Majed Al-Qurashi
PURPOSE: Limited literature documenting the incidence of unsuspected malignant neoplasm among dacryocystorhinostomy/Dacryocystectomy (DCR/DCT) specimens is reviewed to determine if routine biopsy of all the patients undergoing such procedures is required. We are evaluating if sending lacrimal sac specimens for histopathological examination is necessary as a routine patient's care standard. STUDY DESIGN: This is a retrospective study of all lacrimal sac specimens received for histopathological examination in a tertiary eye hospital over a period of 12 years...
February 2017: Canadian Journal of Ophthalmology. Journal Canadien D'ophtalmologie
https://www.readbyqxmd.com/read/28236866/accuracy-of-a-smartphone-to-test-laryngoscope-s-light-and-an-audit-to-our-laryngoscopes-using-an-iso-standard
#13
Diogo Alcino de Abreu Ribeiro Carvalho Machado, Dina da Assunção Azevedo Esteves, Pedro Manuel Araújo de Sousa Branca
BACKGROUND AND OBJECTIVES: Laryngoscope is a key tool in anesthetic practice. Direct laryngoscopy is a crucial moment and inadequate laryngoscope's light can lead to catastrophic consequences. From our experience laryngoscope's light is assessed in a subjective manner and we believe a more precise evaluation should be used. Our objective is to compare the accuracy of a smartphone compared to a lux meter. Secondly we audited our Operating Room laryngoscopes. METHODS: We designed a pragmatic study, using as primary outcome the accuracy of a smartphone compared to the lux meter...
March 2017: Brazilian Journal of Anesthesiology
https://www.readbyqxmd.com/read/28236585/the-importance-of-genetic-counseling-and-genetic-screening-a-case-report-of-a-16-year-old-boy-with-resistant-hypertension-and-severe-hypokalemia
#14
Ze-Min Kuang, Ying Wang, Jia-Jie Wang, Jing-Hua Liu, Rong Zeng, Qi Zhou, Zhen-Qiu Yu, Long Jiang
Liddle's syndrome, an autosomal dominant form of monogenic hypertension, is characterized by salt-sensitive hypertension with early penetrance, hypokalemia, metabolic alkalosis, suppression of plasma rennin activity and aldosterone secretion, and a clear-cut response to epithelial sodium channel blockers but not spironolactone therapy. Here, we describe the case of a 16-year-old boy patient with resistant hypertension (maintain 170-180/100-110 mm Hg after administration four kinds of antiypertensive drugs) and severe hypokalemia...
February 3, 2017: Journal of the American Society of Hypertension: JASH
https://www.readbyqxmd.com/read/28236488/perceived-discrimination-and-self-rated-health-in-the-immigrant-population-of-the-basque-country-spain
#15
Elena Rodriguez-Alvarez, Yolanda González-Rábago, Luisa N Borrell, Nerea Lanborena
OBJECTIVE: To examine the effect of perceived discrimination and self-rated health among the immigrant population in the Basque Country, Spain, and determine whether this effect varies according to region of origin, age, sex and education. METHODS: Descriptive cross-sectional study. The study population included immigrants aged 18 and older residing in the Basque Country. Data from the 2014 Foreign Immigrant Population Survey (n=3,456) were used. Log-binomial regression was used to quantify the association between perceived discrimination and self-rated health before and after checking for the selected characteristics...
February 21, 2017: Gaceta Sanitaria
https://www.readbyqxmd.com/read/28236342/maternal-cardiac-output-in-early-labour-a-possible-link-with-obstetrics-risks
#16
Herbert Valensise, Grazia Maria Tiralongo, Ilaria Pisani, Daniele Farsetti, Damiano Lo Presti, Giulia Gagliardi, Ripalta Marica Basile, Gian Paolo Novelli, Barbara Vasapollo
OBJECTIVE: to verify if the hemodynamic assessment of "low risk" pregnant women at term can improve the identification of patients with a maternal or foetal-neonatal complication during labour MATERIALS AND METHODS: a prospective observational study was conducted on 77 pregnant women at term with diagnosis of initial labour. We obtained haemodynamic indices using the USCOM(®) system. Patients were followed until the end of labour to check for foetal-neonatal and maternal outcomes. RESULTS: Eleven patients (14...
February 25, 2017: Ultrasound in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/28236075/repeatability-and-consistency-of-individual-behaviour-in-juvenile-and-adult-eurasian-harvest-mice
#17
Andrea C Schuster, Teresa Carl, Katharina Foerster
Knowledge on animal personality has provided new insights into evolutionary biology and animal ecology, as behavioural types have been shown to affect fitness. Animal personality is characterized by repeatable and consistent between-individual behavioural differences throughout time and across different situations. Behavioural repeatability within life history stages and consistency between life history stages should be checked for the independence of sex and age, as recent data have shown that males and females in some species may differ in the repeatability of behavioural traits, as well as in their consistency...
April 2017: Die Naturwissenschaften
https://www.readbyqxmd.com/read/28236001/-systematic-errors-in-clinical-studies-a%C3%A2-comprehensive-survey
#18
REVIEW
W A Golder
Systematic errors and related phenomena represent an intrinsic challenge to the quality of clinical research. As a consequence even otherwise methodologically demanding studies may produce results that systematically differ from the true values. Systematic errors relating to investigative medicine are divided into six groups according to their affiliation with the consecutive chronological sections of the study. Bias can occur in preliminary literature research in the field, specifying the study design and selecting the study sample, measuring exposure and outcome, analyzing the data, interpreting the analyses and publishing the results...
February 24, 2017: Der Ophthalmologe: Zeitschrift der Deutschen Ophthalmologischen Gesellschaft
https://www.readbyqxmd.com/read/28235686/the-effects-of-massage-therapy-in-hospitalized-preterm-neonates-a-systematic-review
#19
REVIEW
María José Álvarez, Daniel Fernández, Juan Gómez-Salgado, Dolores Rodríguez-González, María Rosón, Santiago Lapeña
OBJECTIVE: The aim of this study was to perform a systematic review to identify, evaluate and summarise studies on the administration of therapeutic massage to preterm neonates during their stay in the NICU, and to assess their methodological quality. DESIGN: systematic review following PRISMA statements guidelines. DATA SOURCES: A comprehensive search was performed including relevant articles between January 2004 and December 2013, using the following electronic databases: Medline, PEDro, Web of Science and Scopus...
February 14, 2017: International Journal of Nursing Studies
https://www.readbyqxmd.com/read/28231655/-study-on-the-situation-of-drug-use-in-patients-with-chronic-obstructive-pulmonary-diseases-in-the-chinese-communities-of-large-cities
#20
T Xiao, X Y Chen, N Wang, Q Zhao, C W Fu, B Xu
Objectives: To understand the medication being used among patients with chronic obstructive pulmonary diseases (COPD) in Chinese communities of large cities. Methods: A cross-sectional survey was carried out in Beijing, Shanghai, Chengdu and Guangzhou with the total number as 678 COPD cases who were continuously recruited. Subjects were face-to-face interviewed using a structured questionnaire and with medical records checked at the same time. All data were double entered into a database under EpiData 3.1, and analyzed by SAS 9...
February 10, 2017: Zhonghua Liu Xing Bing Xue za Zhi, Zhonghua Liuxingbingxue Zazhi
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