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Polymyalgia rheumatica

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https://www.readbyqxmd.com/read/28185705/cardiovascular-magnetic-resonance-imaging-pattern-at-the-time-of-diagnosis-of-treatment-na%C3%A3-ve-patients-with-connective-tissue-diseases
#1
Sophie Mavrogeni, George Markousis-Mavrogenis, Loukia Koutsogeorgopoulou, Theodoros Dimitroulas, Konstantinos Bratis, George D Kitas, Petros Sfikakis, Maria Tektonidou, Georgia Karabela, Efthymios Stavropoulos, Gikas Katsifis, Kyriaki A Boki, Anastasia Kitsiou, Vasiliki Filaditaki, Elias Gialafos, Sotiris Plastiras, Vasiliki Vartela, Genovefa Kolovou
BACKGROUND-AIM: Cardiac involvement at diagnosis of connective tissue disease (CTD) has been described by echocardiography. We hypothesized that cardio-vascular magnetic resonance (CMR) detects occult lesions at CTD diagnosis. PATIENTS-METHODS: CMR was performed early after diagnosis in 78 treatment-naïve CTDs (aged 43±11, 59F/19M) without cardiac involvement [5 Takayasu arteritis (TA), 4 Churg Strauss syndrome (CSS), 5 Wegener granulomatosis (WG), 16 systemic lupus erythematosus (SLE), 12 rheumatoid arthritis (RA), 8 mixed connective tissue diseases (MCTD), 12 ankylosing spondylitis (AS), 3 polymyalgia rheumatica (PMR), 8 systemic sclerosis (SSc) and 5 dermatomyositis (DM)]...
February 1, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28181122/association-between-rheumatic-diseases-and-cancer-results-from-a-clinical-practice-cohort-study
#2
Mattia Bellan, Enrico Boggio, Daniele Sola, Antonello Gibbin, Alessandro Gualerzi, Serena Favretto, Giulia Guaschino, Ramona Bonometti, Roberta Pedrazzoli, Mario Pirisi, Pier Paolo Sainaghi
The association between cancer and immune-mediated rheumatic conditions is controversial, especially as far as polymyalgia rheumatica (PMR) is concerned. Furthermore, no clinical feature has been shown to be suggestive of a paraneoplastic rheumatic syndrome. With the present study, we aim to address both these issues. The study population comprised N = 1750 patients, including N = 100 with PMR, who attended our tertiary immuno-rheumatology clinic between January 1, 2005 and November 30, 2012. A rheumatic disease was deemed paraneoplastic if cancer had been diagnosed in the 2 years preceding or following its onset...
February 8, 2017: Internal and Emergency Medicine
https://www.readbyqxmd.com/read/28122836/patients-views-on-the-causes-of-their-polymyalgia-rheumatica-a-content-analysis-of-data-from-the-pmr-cohort-study
#3
Maatla Tshimologo, Benjamin Saunders, Sara Muller, Christian D Mallen, Samantha L Hider
OBJECTIVE: To explore primary care polymyalgia rheumatica (PMR) patient beliefs about the causes of their PMR. DESIGN: Qualitative content analysis was conducted on patients' written responses to the question of what they thought had caused their PMR. All data were coded and emergent categories of causal beliefs identified. SETTING: Community patients receiving primary care at general practitioner (GP) practices across England. PARTICIPANTS: Participants were recruited from a primary care PMR inception cohort (n=654)...
January 25, 2017: BMJ Open
https://www.readbyqxmd.com/read/28122554/evaluating-on-line-health-information-for-patients-with-polymyalgia-rheumatica-a-descriptive-study
#4
Arani Vivekanantham, Joanne Protheroe, Sara Muller, Samantha Hider
BACKGROUND: The Internet is increasingly used to access health information, although the quality of information varies. The aim of this study was to evaluate the readability, and quality of websites about polymyalgia rheumatica (PMR). METHODS: Three UK search engines (Google, Yahoo and Bing) were searched for the term 'polymyalgia rheumatica'. After deleting duplicates, the first 50 eligible websites from each were evaluated. Readability was assessed using the Flesch Reading Ease and 'Simple Measure of Gobbledygook (SMOG) Readability' indicators...
January 26, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/28079505/glucocorticoid-withdrawal-in-polymyalgia-rheumatica-the-theory-versus-the-practice
#5
EDITORIAL
Max Yates, Richard A Watts, Francesca Swords, Alexander J MacGregor
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January 5, 2017: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/28004845/polymyalgia-rheumatica-detected-by-spect-ct-using-99m-tc-labeled-monoclonal-antibody-fab-fragments
#6
Anne Frölich, Ilka Schwarze, Christoph Neumann
No abstract text is available yet for this article.
December 22, 2016: Nuklearmedizin. Nuclear Medicine
https://www.readbyqxmd.com/read/27998620/newly-diagnosed-vs-relapsing-giant-cell-arteritis-baseline-data-from-the-giacta-trial
#7
Katie Tuckwell, Neil Collinson, Sophie Dimonaco, Micki Klearman, Daniel Blockmans, Elisabeth Brouwer, Maria C Cid, Bhaskar Dasgupta, Juergen Rech, Carlo Salvarani, Sebastian H Unizony, John H Stone
OBJECTIVE: To report entry criteria and clinical features of patients with newly diagnosed and relapsing giant cell arteritis (GCA) enrolled in a randomized trial of tocilizumab, an interleukin-6 receptor-alpha inhibitor. METHODS: Newly diagnosed GCA was defined as diagnosis ≤6 weeks before baseline. Relapsing GCA was defined as diagnosis >6 weeks before baseline with ≥2 consecutive weeks of prednisone ≥40mg/day. All patients had active GCA within 6 weeks of baseline...
November 15, 2016: Seminars in Arthritis and Rheumatism
https://www.readbyqxmd.com/read/27994267/widespread-headache-as-the-first-clinical-manifestation-of-giant-cell-arteritis-in-patients-affected-by-polymyalgia-rheumatica
#8
Ciro Manzo
INTRODUCTION: In giant cell arteritis (GCA) headache of new onset due to inflammatory involvement of the temporal artery (TA) represents a diagnostic criterion. A widespread headache (WH) with scalp tenderness due to cranial arteritis can represent another manifestation of GCA. MATERIAL AND METHODS: In 225 elderly patients with polymyalgia rheumatica (PMR) followed in our rheumatologic outpatient clinic from 2004 until June 2016, the frequency of WH as the first clinical manifestation of GCA was evaluated...
2016: Reumatologia
https://www.readbyqxmd.com/read/27987494/-significance-of-glucose-6-phosphate-isomerase-assay-in-early-diagnosis-of-rheumatoid-arthritis
#9
J Xu, J Liu, L Zhu, X W Zhang, Z G Li
OBJECTIVE: To explore the titer of glucose-6-phosphate isomerase (GPI) for early diagnosis of the outpatient with rheumatoid arthritis (RA) in real life, and to analyze its relationship with disease activity. METHODS: In the study, 1 051 patients with arthritis were collected in the group who had joints tender and swelling, and 90 cases of healthy people as a control group. ELISA method was used to detect the serum level of GPI, and according to clinical features and laboratory test, all the patients including 525 RA patients, the other patients including osteoarthritis (OA), 134 cases of seronegative spine joint disease (SpA), 104 cases of systemic lupus erythematosus (SLE), 31 cases of primary Sjogren syndrome (pSS), 24 cases of gout arthritis (GA), 22 cases of other connective tissue diseases (including polymyalgia rheumatica, dermatomyositis, systemic sclerosis, adult Still disease) and 46 cases of other diseases (including 165 cases of osteoporosis, avascular necrosis of the femoral head, traumatic osteomyelitis, bone and joint disease, juvenile rheumatoid arthritis, tumor)...
December 18, 2016: Beijing da Xue Xue Bao. Yi Xue Ban, Journal of Peking University. Health Sciences
https://www.readbyqxmd.com/read/27980014/stiffness-is-the-cardinal-symptom-of-inflammatory-musculoskeletal-diseases-yet-still-variably-measured-report-from-the-omeract-2016-stiffness-special-interest-group
#10
Serena Halls, Premarani Sinnathurai, Sarah Hewlett, Sarah L Mackie, Lyn March, Susan J Bartlett, Clifton O Bingham, Rieke Alten, Ina Campbell, Catherine L Hill, Robert J Holt, Rod Hughes, John R Kirwan, Amye L Leong, Ying Ying Leung, Anne Lyddiatt, Lorna Neill, Ana-Maria Orbai
OBJECTIVE: The objectives of the Outcome Measures in Rheumatology (OMERACT) Stiffness special interest group (SIG) are to characterize stiffness as an outcome in rheumatic disease and to identify and validate a stiffness patient-reported outcome (PRO) in rheumatology. METHODS: At OMERACT 2016, international groups presented and discussed results of several concurrent research projects on stiffness: a literature review of rheumatoid arthritis (RA) stiffness PRO measures, a qualitative investigation into the RA and polymyalgia rheumatica patient perspective of stiffness, data-driven stiffness conceptual model development, development and testing of an RA stiffness PRO measure, and a quantitative work testing stiffness items in patients with RA and psoriatic arthritis...
December 15, 2016: Journal of Rheumatology
https://www.readbyqxmd.com/read/27980012/baseline-shoulder-ultrasonography-is-not-a-predictive-marker-of-response-to-glucocorticoids-in-patients-with-polymyalgia-rheumatica-a-12-month-followup-study
#11
Maria Concetta Miceli, Angelo Zoli, Giusy Peluso, Silvia Bosello, Elisa Gremese, Gianfranco Ferraccioli
OBJECTIVE: In this study, we evaluated whether ultrasound (US) subdeltoid bursitis (SB) and/or biceps tenosynovitis (BT) presence at baseline could represent a predictive marker of response to standard therapy after 12 months of followup, and whether a positive US examination could highlight the need of higher maintenance dosage of glucocorticoids (GC) at 6 and 12 months in patients with polymyalgia rheumatica (PMR). METHODS: Sixty-six consecutive patients with PMR underwent bilateral shoulder US evaluations before starting therapy and after 12 months of followup...
December 15, 2016: Journal of Rheumatology
https://www.readbyqxmd.com/read/27974093/serum-immunoglobulin-g4-in-giant-cell-arteritis-and-polymyalgia-rheumatica
#12
Mara Burkel, Fabian Arndt, Jan-Henrik Schirmer, Frank Moosig, Julia Holle
OBJECTIVES: To date, no specific serum marker for giant cell arteritis and polymyalgia rheumatica has been established in routine practice. Therefore, the aim of this study was to examine whether immunoglobulin G4 serum concentrations could be a potential biomarker for the differentiation of both diseases. METHODS: Serum immunoglobulin G4 (IgG4) concentrations were measured in patients with giant cell arteritis (n=41) and polymyalgia rheumatica (n=27) by an in-house enzyme-linked immunosorbent assay...
December 2, 2016: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/27965669/complement-regulator-fhr-3-is-elevated-either-locally-or-systemically-in-a-selection-of-autoimmune-diseases
#13
Nicole Schäfer, Antje Grosche, Joerg Reinders, Stefanie M Hauck, Richard B Pouw, Taco W Kuijpers, Diana Wouters, Boris Ehrenstein, Volker Enzmann, Peter F Zipfel, Christine Skerka, Diana Pauly
The human complement factor H-related protein-3 (FHR-3) is a soluble regulator of the complement system. Homozygous cfhr3/1 deletion is a genetic risk factor for the autoimmune form of atypical hemolytic-uremic syndrome (aHUS), while also found to be protective in age-related macular degeneration (AMD). The precise function of FHR-3 remains to be fully characterized. We generated four mouse monoclonal antibodies (mAbs) for FHR-3 (RETC) without cross-reactivity to the complement factor H (FH)-family. These antibodies detected FHR-3 from human serum with a mean concentration of 1 μg/mL...
2016: Frontiers in Immunology
https://www.readbyqxmd.com/read/27906058/vascular-endothelial-growth-factor-levels-and-rheumatic-diseases-of-the-elderly
#14
Perrine Smets, Valérie Devauchelle-Pensec, Paul-Olivier Rouzaire, Bruno Pereira, Marc Andre, Martin Soubrier
BACKGROUND: Increasing vascular endothelial growth factor (VEGF) has been reported in remitting symmetrical seronegative synovitis with pitting edema (RS3PE) syndrome, rheumatoid arthritis (RA), polymyalgia rheumatica (PMR) and giant cell arteritis (GCA). The aim of this study was to compare VEGF levels in patients over 60 years of age who have RS3PE, RA, PMR or GCA so as to determine whether elevated VEGF is specific for a rheumatic disease, the inflammation or edema that occurs with these pathological conditions...
December 1, 2016: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/27843932/a-case-of-frontal-fibrosing-alopecia-in-a-patient-with-primary-biliary-cirrhosis-and-polymyalgia-rheumatica
#15
Ariana N Eginli, Courtney W Bagayoko, Amy J McMichael
Frontal fibrosing alopecia (FFA) is a form of scarring hair loss that is characterized by hair follicle destruction in a fronto-temporo-parietal distribution. Its etiology is unknown; however, most authors presently favor an immune pathogenesis. Associated autoimmune connective tissue diseases have been reported in patients with FFA. We present a case of FFA in a woman with primary biliary cirrhosis and polymyalgia rheumatica, suggesting an association between these clinical entities and supporting a potential autoimmune etiology of FFA...
September 2016: Skin Appendage Disorders
https://www.readbyqxmd.com/read/27843375/polymyalgia-rheumatica-and-cancer-risk-the-importance-of-the-diagnostic-set
#16
Ciro Manzo, Maria Natale
In the last few years, the relationship between polymyalgia rheumatica (PMR) and cancer has been considered with very different conclusions. In particular, in 2010, Ji et al examined the overall and specific cancer risks among Swedish subjects following hospitalization for PMR and giant cell arteritis and noted that the risk of cancer was highest in the first year after hospitalization (of 3941 total cancer diagnoses, 783 [19.1%] were in the first year). In 2013, Muller et al, using data from General Practice Research Database, highlighted that elderly patients with a PMR diagnosis were significantly more likely to receive a cancer diagnosis in the year after PMR diagnosis (313/667 cancer cases [69%])...
2016: Open Access Rheumatology: Research and Reviews
https://www.readbyqxmd.com/read/27843369/polymyalgia-rheumatica-observations-of-disease-evolution-without-corticosteroid-treatment
#17
Arthur E Brawer
OBJECTIVES: The diagnostic diversity of polymyalgia rheumatica (PMR) can easily be obscured by the widespread use of corticosteroids (CSs) early in the disease course. This study observed the course of PMR without CSs and determined whether alternative medication could be useful. METHODS: Seventy patients with new-onset PMR comprised phase 1. Eight were removed with specific diagnoses (four with giant cell arteritis [GCA]). The remaining 62 were treated with nonsteroidal anti-inflammatory drugs (NSAIDs) alone until enough time had elapsed to ascertain whether their PMR had evolved into another rheumatologic inflammatory condition...
2016: Open Access Rheumatology: Research and Reviews
https://www.readbyqxmd.com/read/27824543/giant-cell-arteritis-and-polymyalgia-rheumatica-2016-update
#18
REVIEW
Gideon Nesher, Gabriel S Breuer
Giant cell arteritis (GCA) and polymyalgia rheumatica (PMR) are both more common among people of North European decent than among Mediterranean people. Women are 2-3 times more commonly affected. Giant cell arteritis and PMR are extremely rare before age 50 years. Polymyalgia rheumatica may be "isolated" or associated with GCA. There is increased expression of inflammatory cytokines in temporal arteries of PMR patients, without overt histological evidence of arteritis. One-third of "isolated" PMR patients have vascular uptake in positron emission tomography (PET) scans, suggesting clinically unrecognized, "hidden" GCA...
October 31, 2016: Rambam Maimonides Medical Journal
https://www.readbyqxmd.com/read/27768840/epidemiology-of-polymyalgia-rheumatica-2000-2014-and-examination-of-incidence-and-survival-trends-over-45-years-a-population-based-study
#19
Shafay Raheel, Izzat Shbeeb, Cynthia S Crowson, Eric L Matteson
OBJECTIVE: To determine time trends in the incidence and survival of polymyalgia rheumatica (PMR) over a 15 year period in Olmsted County, Minnesota, USA and to examine trends in incidence of PMR in the population by comparing this time period to a previous incidence cohort from the same population base. METHODS: All cases of incident PMR among Olmsted County, Minnesota residents in 2000-2014 were identified to extend the previous 1970-1999 cohort. Detailed review of all individual medical records was performed...
October 21, 2016: Arthritis Care & Research
https://www.readbyqxmd.com/read/27738520/interleukin-6-a-promising-target-for-the-treatment-of-polymyalgia-rheumatica-or-giant-cell-arteritis
#20
EDITORIAL
Éric Toussirot, Alexis Régent, Valérie Devauchelle-Pensec, Alain Saraux, Xavier Puéchal
No abstract text is available yet for this article.
2016: RMD Open
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