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Polymyalgia rheumatica

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https://www.readbyqxmd.com/read/27906058/vascular-endothelial-growth-factor-levels-and-rheumatic-diseases-of-the-elderly
#1
Perrine Smets, Valérie Devauchelle-Pensec, Paul-Olivier Rouzaire, Bruno Pereira, Marc Andre, Martin Soubrier
BACKGROUND: Increasing vascular endothelial growth factor (VEGF) has been reported in remitting symmetrical seronegative synovitis with pitting edema (RS3PE) syndrome, rheumatoid arthritis (RA), polymyalgia rheumatica (PMR) and giant cell arteritis (GCA). The aim of this study was to compare VEGF levels in patients over 60 years of age who have RS3PE, RA, PMR or GCA so as to determine whether elevated VEGF is specific for a rheumatic disease, the inflammation or edema that occurs with these pathological conditions...
December 1, 2016: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/27843932/a-case-of-frontal-fibrosing-alopecia-in-a-patient-with-primary-biliary-cirrhosis-and-polymyalgia-rheumatica
#2
Ariana N Eginli, Courtney W Bagayoko, Amy J McMichael
Frontal fibrosing alopecia (FFA) is a form of scarring hair loss that is characterized by hair follicle destruction in a fronto-temporo-parietal distribution. Its etiology is unknown; however, most authors presently favor an immune pathogenesis. Associated autoimmune connective tissue diseases have been reported in patients with FFA. We present a case of FFA in a woman with primary biliary cirrhosis and polymyalgia rheumatica, suggesting an association between these clinical entities and supporting a potential autoimmune etiology of FFA...
September 2016: Skin Appendage Disorders
https://www.readbyqxmd.com/read/27843375/polymyalgia-rheumatica-and-cancer-risk-the-importance-of-the-diagnostic-set
#3
Ciro Manzo, Maria Natale
In the last few years, the relationship between polymyalgia rheumatica (PMR) and cancer has been considered with very different conclusions. In particular, in 2010, Ji et al examined the overall and specific cancer risks among Swedish subjects following hospitalization for PMR and giant cell arteritis and noted that the risk of cancer was highest in the first year after hospitalization (of 3941 total cancer diagnoses, 783 [19.1%] were in the first year). In 2013, Muller et al, using data from General Practice Research Database, highlighted that elderly patients with a PMR diagnosis were significantly more likely to receive a cancer diagnosis in the year after PMR diagnosis (313/667 cancer cases [69%])...
2016: Open Access Rheumatology: Research and Reviews
https://www.readbyqxmd.com/read/27843369/polymyalgia-rheumatica-observations-of-disease-evolution-without-corticosteroid-treatment
#4
Arthur E Brawer
OBJECTIVES: The diagnostic diversity of polymyalgia rheumatica (PMR) can easily be obscured by the widespread use of corticosteroids (CSs) early in the disease course. This study observed the course of PMR without CSs and determined whether alternative medication could be useful. METHODS: Seventy patients with new-onset PMR comprised phase 1. Eight were removed with specific diagnoses (four with giant cell arteritis [GCA]). The remaining 62 were treated with nonsteroidal anti-inflammatory drugs (NSAIDs) alone until enough time had elapsed to ascertain whether their PMR had evolved into another rheumatologic inflammatory condition...
2016: Open Access Rheumatol
https://www.readbyqxmd.com/read/27824543/giant-cell-arteritis-and-polymyalgia-rheumatica-2016-update
#5
REVIEW
Gideon Nesher, Gabriel S Breuer
Giant cell arteritis (GCA) and polymyalgia rheumatica (PMR) are both more common among people of North European decent than among Mediterranean people. Women are 2-3 times more commonly affected. Giant cell arteritis and PMR are extremely rare before age 50 years. Polymyalgia rheumatica may be "isolated" or associated with GCA. There is increased expression of inflammatory cytokines in temporal arteries of PMR patients, without overt histological evidence of arteritis. One-third of "isolated" PMR patients have vascular uptake in positron emission tomography (PET) scans, suggesting clinically unrecognized, "hidden" GCA...
October 31, 2016: Rambam Maimonides Medical Journal
https://www.readbyqxmd.com/read/27768840/epidemiology-of-polymyalgia-rheumatica-2000-2014-and-examination-of-incidence-and-survival-trends-over-45-years-a-population-based-study
#6
Shafay Raheel, Izzat Shbeeb, Cynthia S Crowson, Eric L Matteson
OBJECTIVE: To determine time trends in the incidence and survival of polymyalgia rheumatica (PMR) over a 15 year period in Olmsted County, Minnesota, USA and to examine trends in incidence of PMR in the population by comparing this time period to a previous incidence cohort from the same population base. METHODS: All cases of incident PMR among Olmsted County, Minnesota residents in 2000-2014 were identified to extend the previous 1970-1999 cohort. Detailed review of all individual medical records was performed...
October 21, 2016: Arthritis Care & Research
https://www.readbyqxmd.com/read/27738520/interleukin-6-a-promising-target-for-the-treatment-of-polymyalgia-rheumatica-or-giant-cell-arteritis
#7
EDITORIAL
Éric Toussirot, Alexis Régent, Valérie Devauchelle-Pensec, Alain Saraux, Xavier Puéchal
No abstract text is available yet for this article.
2016: RMD Open
https://www.readbyqxmd.com/read/27708949/differential-diagnosis-of-elevated-erythrocyte-sedimentation-rate-and-c-reactive-protein-levels-a-rheumatology-perspective
#8
Berivan Bitik, Rıdvan Mercan, Abdurrahman Tufan, Engin Tezcan, Hamit Küçük, Mustafa İlhan, Mehmet Akif Öztürk, Seminur Haznedaroğlu, Berna Göker
OBJECTIVE: In the case of high erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) levels, the diagnosis of the underlying disease can be challenging especially in serologically unrevealing patients who have nonspecific clinical findings. We aimed to investigate the final distribution of definitive diagnoses in patients who initially presented with nonspecific clinical findings and sustained elevations in serum ESR/CRP levels. MATERIAL AND METHODS: The medical records of patients hospitalized in a rheumatology clinic between January 2010 and January 2011 were retrospectively analyzed...
December 2015: European Journal of Rheumatology
https://www.readbyqxmd.com/read/27687304/anti-pd-1-therapy-in-patients-with-advanced-melanoma-and-preexisting-autoimmune-disorders-or-major-toxicity-with-ipilimumab
#9
A M Menzies, D B Johnson, S Ramanujam, V G Atkinson, A N M Wong, J J Park, J L McQuade, A N Shoushtari, K K Tsai, Z Eroglu, O Klein, J C Hassel, J A Sosman, A Guminski, R J Sullivan, A Ribas, M S Carlino, M A Davies, S K Sandhu, G V Long
BACKGROUND: Anti-PD-1 antibodies (anti-PD-1) have clinical activity in a number of malignancies. All clinical trials have excluded patients with significant preexisting autoimmune disorders (ADs), and only one has included patients with immune-related adverse events (irAEs) with ipilimumab. We sought to explore the safety and efficacy of anti-PD-1 in such patients. PATIENTS AND METHODS: Patients with advanced melanoma and preexisting ADs and/or major immune-related adverse events (irAEs) with ipilimumab (requiring systemic immunosuppression) that were treated with anti-PD-1 between 1(st) July 2012 and 30(th) September 2015 were retrospectively identified...
September 29, 2016: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/27631531/-management-of-polymyalgia-rheumatica-and-large-vessel-vasculitis
#10
B Hellmich
Imaging methods, such as joint and color duplex sonography, magnetic resonance imaging (MRI) and positron emission tomography (PET) nowadays facilitate the diagnosis of polymyalgia rheumatica and large vessel vasculitides and have now been included in the new classification criteria. In patients with typical symptoms, color duplex sonography of the temporal artery can replace a biopsy of the temporal artery for the diagnosis of giant cell arteritis (GCA); however, the role of these methods for patient follow-up and assessment of prognosis is unclear...
November 2016: Der Internist
https://www.readbyqxmd.com/read/27625228/polymyalgia-rheumatica-and-the-risk-of-cerebrovascular-accident
#11
Apratim Chatterjee, Shyamal Kumar Das
No abstract text is available yet for this article.
September 2016: Neurology India
https://www.readbyqxmd.com/read/27625227/polymyalgia-rheumatica-and-risk-of-cerebrovascular-accident-a-systematic-review-and-meta-analysis
#12
Patompong Ungprasert, Narat Srivali, Charat Thongprayoon
BACKGROUND: Several chronic inflammatory disorders, such as rheumatoid arthritis and systemic lupus erythematosus, have been linked to an increased risk of cerebrovascular accident (CVA), but the data on polymyalgia rheumatica (PMR) remains unclear. MATERIALS AND METHODS: We conducted a systematic review and meta-analysis of observational studies that reported odds ratio, relative risk, hazard ratio, or standardized incidence ratio comparing the risk of CVA in patients with PMR versus non-PMR controls...
September 2016: Neurology India
https://www.readbyqxmd.com/read/27605116/characterising-those-with-incident-polymyalgia-rheumatica-in-primary-care-results-from-the-pmr-cohort-study
#13
Sara Muller, Samantha L Hider, Toby Helliwell, Sarah Lawton, Kevin Barraclough, Bhaskar Dasgupta, Irena Zwierska, Christian D Mallen
BACKGROUND: The aim was to characterise the sociodemographic, general health and polymyalgia rheumatica (PMR)-specific features of participants in a large inception cohort of patients with PMR diagnosed in UK primary care. METHODS: Patients (n = 739) with a new diagnosis of PMR were referred into the study and mailed a questionnaire detailing their general health and sociodemographic characteristics in addition to the symptoms of and treatment for PMR. Characteristics of responders and non-responders were compared and descriptive statistics were used to characterise the health of the cohort...
2016: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/27597921/polymyalgia-rheumatica-revealing-a-lymphoma-a-two-case-report
#14
Frank Verhoeven, Xavier Guillot, Mickaël Chouk, Clément Prati, Daniel Wendling
Introduction. Polymyalgia rheumatica (PMR) is one of the most common inflammatory rheumatism types in elderly population. The link between cancer and PMR is a matter of debate. Methods. We report two cases of PMR leading to the diagnosis of lymphoma and the growing interest of PET-TDM in this indication. Results. A 84-year-old man known for idiopathic neutropenia presented an inflammatory arthromyalgia of the limb girdle since one month. Blood exams highlighted the presence of a monoclonal B cell clone. Bone marrow concluded to a B cell lymphoma of the marginal zone...
2016: Case Reports in Rheumatology
https://www.readbyqxmd.com/read/27577940/polymyalgia-rheumatica-and-risk-of-coronary-artery-disease-a-systematic-review-and-meta-analysis-of-observational-studies
#15
Patompong Ungprasert, Matthew J Koster, Kenneth J Warrington, Eric L Matteson
Several chronic inflammatory disorders, such as rheumatoid arthritis and systemic lupus erythematosus, are associated with an increased risk of coronary artery disease (CAD) as a result of accelerated atherosclerosis. However, the data on CAD risk of polymyalgia rheumatica (PMR), one of the most common chronic inflammatory disorders in older adults, remain unclear due to limited number of epidemiological studies. To further investigate this possible association, this systematic review and meta-analysis of observational studies was performed to compare the risk of CAD in patients with PMR versus subjects without it...
August 30, 2016: Rheumatology International
https://www.readbyqxmd.com/read/27558589/the-effect-of-clinical-features-and-glucocorticoids-on-biopsy-findings-in-giant-cell-arteritis
#16
Karin Jakobsson, Lennart Jacobsson, Aladdin J Mohammad, Jan-Åke Nilsson, Kenneth Warrington, Eric L Matteson, Carl Turesson
BACKGROUND: To investigate the effect of baseline clinical characteristics and glucocorticoid treatment on temporal artery biopsy (TAB) findings in patients with giant cell arteritis (GCA). METHODS: Individuals who developed GCA after inclusion in two population-based health surveys were identified through linkage to the local and the national patient registers. In addition, other patients diagnosed with GCA at the Departments of Internal Medicine and Rheumatology at an area hospital were included...
2016: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/27556960/diagnosing-light-chain-amyloidosis-on-temporal-artery-biopsies-for-suspected-giant-cell-arteritis
#17
Rosanna A M Ghinai, Shameem Mahmood, Pinias Mukonoweshuro, Sally Webber, Ashutosh D Wechalekar, Sally E Moore
Although still rarely diagnosed, amyloid light chain (AL) amyloidosis is the most common form of systemic amyloidosis. It is characterized by misfolded monoclonal immunoglobulin light chain fragments that accumulate extracellularly as amyloid fibrils, with consequent organ dysfunction. We report 2 such cases where initial symptoms and signs were identical to and mistaken for those of giant cell arteritis, associated with polymyalgia rheumatica. Neither patient responded to high-dose corticosteroids; instead, their temporal artery biopsies revealed amyloid deposits and other investigations confirmed a diagnosis of systemic AL amyloidosis...
August 23, 2016: Journal of Neuro-ophthalmology: the Official Journal of the North American Neuro-Ophthalmology Society
https://www.readbyqxmd.com/read/27526638/has-the-time-come-for-biotherapies-in-giant-cell-arteritis-and-polymyalgia-rheumatica
#18
EDITORIAL
Valérie Devauchelle-Pensec
No abstract text is available yet for this article.
October 2016: Joint, Bone, Spine: Revue du Rhumatisme
https://www.readbyqxmd.com/read/27499837/autoimmune-syndromes-presenting-as-a-paraneoplastic-manifestation-of-myelodysplastic-syndromes-clinical-features-course-treatment-and-outcome
#19
Bradley T Williamson, Lynda Foltz, Heather A Leitch
Autoimmune manifestations (AIM) are reported in up to 10-30% of myelodysplastic syndromes (MDS) patients; this association is not well defined. We present herein a retrospective chart review of single center MDS patients for AIM, a case discussion and a literature review. Of 252 MDS patients examined, 11 (4.4%) had AIM around MDS diagnosis. International Prognostic Scoring System scores were: low or intermediate (int)-1 (n=7); int-2 or high (n=4). AIM were: culture negative sepsis (n=7); inflammatory arthritis (n=3); vasculitis (n=4); sweats; pericarditis; polymyalgia rheumatica (n=2 each); mouth ulcers; pulmonary infiltrates; suspicion for Behcet's; polychondritis and undifferentiated (n=1 each)...
May 10, 2016: Hematology Reports
https://www.readbyqxmd.com/read/27499427/sustained-remission-after-long-term-biological-therapy-in-patients-with-large-vessel-vasculitis-an-analysis-of-ten-cases
#20
Juan P Vinicki, Rosario García-Vicuña, Miguel Arredondo, Juan P López-Bote, Jesús A García-Vadillo, Santos Castañeda, José M Álvaro-Gracia
OBJECTIVES: To describe the results obtained in clinical practice with the use of biological therapy (BT) in patients diagnosed with Takayasu arteritis (TA) and giant cell arteritis (GCA). METHODS: Retrospective single center study of TA/GCA patients who received BT (infliximab [IFX], etanercept [ETN] and tocilizumab [TCZ]). In TA, active disease was defined according to a previous National Institutes of Health study. In GCA, active disease was defined with a modified criteria and clinical manifestations secondary to temporal artery involvement or polymyalgia rheumatica symptoms...
August 4, 2016: Reumatología Clinica
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