Use the keywords feature with a free QxMD account.
Use Read by QxMD to access full text via your institution or open access sources.
Read also provides personalized recommendations to keep you up to date in your field.
Existing User
Sign InNew to Read
Sign Up#21
JOURNAL ARTICLE
Stav Spinzi, Gunjan Agrawal, Aditi Sharma, Pranaya Venkatapuram, Kritika Sharma, Cati Brown-Johnson, Kathleen M Kan
BACKGROUND: Paediatric lower urinary tract symptoms (LUTS) are common experiences among school-aged children, with prevalence rates reaching as high as 20%. Paediatricians are often first-line stakeholders in providing treatment for these bothersome symptoms, yet there is no formal resource to support them with the treatment of LUTS. Evaluating paediatricians' experiences is an important step in informing health promotion efforts to improve health outcomes in children. This study aims to explore paediatricians' knowledge, beliefs, practice patterns, and perceived barriers and facilitators in providing LUTS care...
April 2, 2024: BMJ Paediatrics Open
#22
JOURNAL ARTICLE
Florin V Hopland-Nechita, John R Andersen, Christian Beisland
OBJECTIVE: This study aimed to identify clinical and biochemical predictors for future surgical intervention in male LUTS patients. MATERIALS AND METHODS: In a prospective cohort study, parameters as International Prostate Symptom Score (IPSS) and IPSS "bother question" (IPSS-BQ), prostate volume (PV), maximal urine flow (Qmax), Prostate specific antigen (PSA), post-voidal residual urine (PVR) were assessed alongside comorbidities quantified using Charlson Comorbidity Index without age adjustment and American Society of Anesthesiology (ASA) score...
April 2, 2024: Urologia
#23
JOURNAL ARTICLE
Yanchen Lyu, Ming Jiang, Mingyang Zhu, Xinyu Zhong, Chunming Zhao
Efficient error correction in high-speed communication networks, such as the 50G passive optical network (50G-PON), is paramount. This Letter focuses on optimizing a layered non-surjective finite alphabet iterative decoder (LNS-FAID) for 50G-PON, with an emphasis on high-throughput and low-power consumption. We propose using a distinct lookup table (LUT) for each iteration to enhance decoding performance and lower error floors. Additionally, we improve the 2-bit LNS-FAID architecture by adding operational states and a sign backtracking (SBT) strategy...
April 1, 2024: Optics Letters
#24
Mohammed Enamul Hoque, Mohammad Lutful Kabir, Sajad Shiekh, Hamza Balci, Soumitra Basu
Putative G-quadruplex forming sequences (PQS) have been identified in promoter sequences of prominent genes that are implicated among others in cancer and neurological disorders. We explored mechanistic aspects of CRISPR-dCas9-mediated gene expression regulation, which is transient and sequence specific unlike alternative approaches that lack such specificity or create permanent mutations, using the PQS in tyrosine hydroxylase ( TH ) and c-Myc promoters as model systems. We performed in vitro ensemble and single molecule investigations to study whether G-quadruplex (GQ) structures or dCas9 impede T7 RNA polymerase (RNAP) elongation process and whether orientation of these factors is significant...
March 17, 2024: bioRxiv
#25
Steven Bergmans, Nicole C L Noel, Luca Masin, Ellen G Harding, Aleksandra M Krzywańska, Julie D De Schutter, Rajagopal Ayana, Chi-Kuo Hu, Lut Arckens, Philip A Ruzycki, Ryan B MacDonald, Brian S Clark, Lieve Moons
UNLABELLED: Age-related vision loss caused by retinal neurodegenerative pathologies is becoming more prevalent in our ageing society. To understand the physiological and molecular impact of ageing on retinal homeostasis, we used the short-lived African turquoise killifish, a model known to naturally develop central nervous system (CNS) ageing hallmarks and vision loss. Bulk and single-cell RNA-sequencing (scRNA-seq) of three age groups (6-, 12-, and 18-week-old) identified transcriptional ageing fingerprints in the killifish retina, unveiling pathways also identified in the aged brain, including oxidative stress, gliosis, and inflammageing...
March 11, 2024: bioRxiv
#26
JOURNAL ARTICLE
Wei Chen, Jun-Wen Yu, Yu-Yi Deng, Lut Yi Wong, Chen Wang, Yu-Ling Liang, Yuk-Tung Leung, Jia-Yi Tian, Ying Wu, Kelvin Sze-Yin Leung, Jinhui Hu, Wen-Hua Chen, Xiaobing Dou, Xiu-Qiong Fu, Ying-Jie Chen, Zhi-Ling Yu
BACKGROUND: Five Polyporales mushrooms, namely Amauroderma rugosum, Ganoderma lucidum, G. resinaceum, G. sinense and Trametes versicolor, are commonly used in China for managing insomnia. However, their active components for this application are not fully understood, restricting their universal recognition. PURPOSE: In this study, we aimed to identify sedative-hypnotic compounds shared by these five Polyporales mushrooms. STUDY DESIGN AND METHODS: A UPLC-Q-TOF-MS/MS-based untargeted metabolomics, including OPLS-DA (orthogonal projection of potential structure discriminant analysis) and OPLS (orthogonal projections to latent structures) analysis together with mouse assays, were used to identify the main sedative-hypnotic compounds shared by the five Polyporales mushrooms...
January 12, 2024: Phytomedicine
#27
JOURNAL ARTICLE
Md Lutful Amin, Damia Mawad, Socrates Dokos, Charles C Sorrell
The sulfated marine polysaccharides, fucoidan and λ-carrageenan, are known to possess anti-inflammatory, immunomodulatory, and cellular protective properties. Although they hold considerable promise for tissue engineering constructs, their covalent cross-linking in hydrogels and comparative bioactivities to cells are absent from the literature. Thus, fucoidan and λ-carrageenan were modified with methacrylate groups and were covalently cross-linked with the synthetic polymer poly(vinyl alcohol)-methacrylate (PVA-MA) to form 20 wt % biosynthetic hydrogels...
March 30, 2024: Biomacromolecules
#28
JOURNAL ARTICLE
Shuang Chai, Yanbing Yang, Liwei Wei, Yuju Cao, Jiangtao Ma, Xuxia Zheng, Junyan Teng, Na Qin
BACKGROUND: Recently, osteoblast pyroptosis has been proposed as a potential pathogenic mechanism underlying osteoporosis, although this remains to be confirmed. Luteolin (Lut), a flavonoid phytochemical, plays a critical role in the anti-osteoporosis effects of many traditional Chinese medicine prescriptions. However, its protective impact on osteoblasts in postmenopausal osteoporosis (PMOP) has not been elucidated. PURPOSE: This research aimed to determine the effect of Lut in ameliorating PMOP by alleviating osteoblast pyroptosis and sustaining osteogenesis...
March 16, 2024: Phytomedicine
#29
JOURNAL ARTICLE
Yujian Jia, Huisheng Ge, Liling Xiong, Lulu Wang, Jieru Peng, Ying Liu, Jie Yu, Jianmei Liao, Hui Wang, Xiaoqin Gan, Yonghong Lin
We conducted a randomized controlled trial to assess the feasibility and safety of performing gynecological single-port transumbilical laparoscopic-assisted adnexal surgery without urethral catheterization in a day surgery setting. A total of 153 patients with adnexal disease were enrolled in this prospective randomized controlled trial (RCT). All subjects performed single-port transumbilical laparoscopic-assisted adnexal surgery between March 2021 and July 2022 in a day surgery center. After completion of the baseline survey, participants were randomized into one of three groups...
March 30, 2024: Heliyon
#30
JOURNAL ARTICLE
Claire Gkatzoudi, Izolde Bouloukaki, Charalampos Mamoulakis, Christos Lionis, Ioanna Tsiligianni
Background and Objectives : The significant prevalence of Lower Urinary Tract Symptoms (LUTS), erectile dysfunction (ED), and associated adverse effects calls for increased attention in primary care settings. In Greece, there is a lack of sufficient data for LUTS and ED screening in primary care. Therefore, the aim of our study was to estimate the prevalence of LUTS and ED, identify associated risk factors, and evaluate their impact on quality of life among adult primary healthcare users aged 40 years and older in Crete, Greece...
February 25, 2024: Medicina
#31
JOURNAL ARTICLE
Masroor Badshah, Jibriil Ibrahim, Nguok Su, Penny Whiley, Ralf Middendorff, Michael Whittaker, Betty Exintaris
Overactive bladder (OAB) is an age-related disorder characterised by unstable bladder contractions resulting in disruptive lower urinary tract symptoms (LUTS), thus creating a profound impact on an individual's quality of life. The development of LUTS may be linked to the overexpression of oxytocin receptors (OXTRs) within the bladder detrusor muscle, resulting in increased baseline myogenic tone. Thus, it is hypothesised that targeting OXTRs within the bladder using oxytocin antagonists may attenuate myogenic tone within the bladder, thereby providing a new therapeutic avenue for treating OAB...
March 18, 2024: Biomedicines
#32
REVIEW
Huanxian Chen, Maggie Pui Man Hoi, Simon Ming Yuen Lee
BACKGROUND: Overactive bladder (OAB) presents a high prevalence of 16-18% worldwide. The pathophysiology of OAB is still poorly understood while effective therapy or countermeasure are very limited. On the other hand, medicinal plants and herbal remedies have been utilized for treating lower urinary tract symptoms (LUTS) in both Eastern and Western cultures since ancient times. In recent years, accumulating progress has also been made in OAB treatment research by using medicinal plants...
March 27, 2024: Chinese Medicine
#33
JOURNAL ARTICLE
Josephina A N Meester, Anne Hebert, Maaike Bastiaansen, Laura Rabaut, Jarl Bastianen, Nele Boeckx, Kathryn Ashcroft, Paldeep S Atwal, Antoine Benichou, Clarisse Billon, Jan D Blankensteijn, Paul Brennan, Stephanie A Bucks, Ian M Campbell, Solène Conrad, Stephanie L Curtis, Majed Dasouki, Carolyn L Dent, James Eden, Himanshu Goel, Verity Hartill, Arjan C Houweling, Bertrand Isidor, Nicola Jackson, Pieter Koopman, Anita Korpioja, Minna Kraatari-Tiri, Liina Kuulavainen, Kelvin Lee, Karen J Low, Alan C Lu, Morgan L McManus, Stephen P Oakley, James Oliver, Nicole M Organ, Eline Overwater, Nicole Revencu, Alison H Trainer, Bhavya Trivedi, Claire L S Turner, Rebecca Whittington, Andreas Zankl, Dominica Zentner, Lut Van Laer, Aline Verstraeten, Bart L Loeys
Pathogenic loss-of-function variants in BGN, an X-linked gene encoding biglycan, are associated with Meester-Loeys syndrome (MRLS), a thoracic aortic aneurysm/dissection syndrome. Since the initial publication of five probands in 2017, we have considerably expanded our MRLS cohort to a total of 18 probands (16 males and 2 females). Segregation analyses identified 36 additional BGN variant-harboring family members (9 males and 27 females). The identified BGN variants were shown to lead to loss-of-function by cDNA and Western Blot analyses of skin fibroblasts or were strongly predicted to lead to loss-of-function based on the nature of the variant...
March 26, 2024: NPJ Genomic Medicine
#34
JOURNAL ARTICLE
Gautier Müllhaupt, Lukas Hechelhammer, Nicole Graf, Livio Mordasini, Hans-Peter Schmid, Daniel S Engeler, Dominik Abt
BACKGROUND AND OBJECTIVE: Prostatic artery embolisation (PAE) and transurethral resection of the prostate (TURP) are two of the surgical options for treatment of lower urinary tract symptoms/benign prostatic obstruction (LUTS/BPO). Our aim was to compare the efficacy and safety of PAE and TURP for LUTS/BPO treatment at long-term follow-up. METHODS: We conducted a randomised, open-label, single-centre trial at a Swiss tertiary care centre. The main outcome was the change in International Prostate Symptom Score (IPSS) after PAE versus TURP...
March 25, 2024: European Urology Focus
#35
JOURNAL ARTICLE
Theodora A M Teunissen, Antoinette L M Lagro-Janssen, Reinier P Akkermans, Marco H Blanker, Grietje E Knol-de Vries
OBJECTIVES: To study the possible association between (sexual) abuse and lower urinary tract symptoms (LUTS) in men and women. To study the differences in this association between men and women, and between the timing of the abuse. SUBJECTS AND METHODS: A Dutch observational population-based cross-sectional study was used, based on self-administered questionnaires. Respondents were included if they had answered all questions about abuse and LUTS. Logistic regression was used to analyse the data...
March 26, 2024: Neurourology and Urodynamics
#36
JOURNAL ARTICLE
Marilena Gubbiotti, Matteo Balzarro, Leonardo Zoccante, Gianfranco Di Gennaro, Moreno Marchiafava, Chiara Bedetti, Emanuele Rubilotta
INTRODUCTION: To evaluate lower urinary tract symptoms (LUTS) and bowel disorders in a population of young subjects with autism spectrum disorder (ADS) by a national survey and to assess the relationship between the occurrence, frequency, and type of LUTS and the severity of behavioral and neuropsychiatric characteristics. MATERIALS AND METHODS: A survey on LUTS and bowel disorders in the ASD population was sent by mail and social media through the main Italian Associations of ASD between February and September 2022...
2024: Frontiers in Psychiatry
#37
JOURNAL ARTICLE
Murat Can Karaburun, Eralp Kubilay, Derya Öztuna, Mehmet İlker Gökçe, Evren Süer, Ömer Gülpınar
OBJECTIVES: To determine the effect of intravesical onabotulinum toxin-A (BoNT-A) treatment on sexual functions in female patients with refractory interstitial cystitis/bladder pain syndrome (IC/BPS). METHODS: Female patients with IC/BPS refractory to previous treatments were included in the study between January 2020 and April 2022. Patients were treated with the trigone-sparing injection (Group 1) or trigone-included injection (Group 2) techniques. 100 Units of BoNT-A was applied submucosally on 20 different points...
March 2024: Lower Urinary Tract Symptoms
#38
JOURNAL ARTICLE
Keiji Sugai, Junko Sasaki, Yuki Wada, Norihiro Shimizu, Takuya Ishikawa, Ketchu Yanagi, Takeshi Hashimoto, Akihiko Tanaka, Hirotsugu Suwanai, Ryo Suzuki, Masato Odawara
BACKGROUND: Numerous studies demonstrated the risk factors for urological complications in patients with diabetes before sodium-glucose co-transporter 2 inhibitor (SGLT2i) became commercially available. This study aimed to comprehensively investigate urological characteristics in patients with type 2 diabetes (T2DM) after SGLT2i became commercially available. METHODS: We examined 63 outpatients with T2DM suspected of bacteriuria based on urinary sediment examinations...
April 2024: Diabetology International
#39
JOURNAL ARTICLE
Sabrina Einig, Esther Ruess, Andreas Schoetzau, Kerstin Ayllon Bartet, Viola Heinzelmann-Schwarz, Francesco Vigo, Tilemachos Kavvadias
INTRODUCTION: Women with lower urinary tract symptoms (LUTS) and high-tone pelvic floor often experience pain and have positive trigger points upon pelvic floor examination. However, the correlation of these findings has not yet been systematically examined and sufficiently understood. The aim of this cross-sectional study is to examine the correlation of pelvic myofascial pain with LUTS and pelvic floor tone. MATERIALS AND METHODS: All participants filled a standardized pelvic floor questionnaire to assess LUTS, which consists of a total of 43 questions regarding bladder, bowel, and sexual function as well as prolapse symptoms...
2024: Advances in Urology
#40
JOURNAL ARTICLE
Cagri Akin Sekerci, Yiloren Tanidir, Gunal Ozgur, Raziye Ergun, Mehmet Cetin, Tufan Tarcan, Selcuk Yucel
BACKGROUND: Maximum voided volumes (MVV) and maximum bladder capacities (MBC) are important parameters in the evaluation of lower urinary tract functions in children. However, consistency of MVV and MBC measurements between voiding diary (VD), uroflowmetry (UF) and cystometrography (CMG) in children with non-neurogenic lower urinary tract dysfunction (LUTD) has not been addressed specifically. OBJECTIVE: We aimed to compare the MVV in VD and UF and MBC in CMG in children with non-neurogenic LUT dysfunction and investigate for possible factors for discrepancies...
March 15, 2024: Journal of Pediatric Urology
Make the most of Read.
Download the mobile app.
Download the mobile app.
Fetching more papers... 
