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https://www.readbyqxmd.com/read/29024827/left-ventricular-non-compaction-with-ebstein-anomaly-attributed-to-a-tpm1-mutation
#1
Aleksandra Nijak, Maaike Alaerts, Cuno Kuiperi, Anniek Corveleyn, Bert Suys, Bernard Paelinck, Johan Saenen, Emeline Van Craenenbroeck, Lut Van Laer, Bart Loeys, Aline Verstraeten
Left ventricular non-compaction (cardiomyopathy) (LVN(C)) is a rare hereditary cardiac condition, resulting from abnormal embryonic myocardial development. While it mostly occurs as an isolated condition, association with other cardiovascular manifestations such as Ebstein anomaly (EA) has been reported. This congenital heart defect is characterized by downward displacement of the tricuspid valve and leads to diminished ventricular size and function. In an autosomal dominant LVN(C) family consisting of five affected individuals, of which two also presented with EA and two others with mitral valve insufficiency, we pursued the genetic disease cause using whole exome sequencing (WES)...
October 9, 2017: European Journal of Medical Genetics
https://www.readbyqxmd.com/read/28990728/female-bladder-outlet-obstruction-common-symptoms-masking-an-uncommon-cause
#2
Sachin Malde, Eskinder Solomon, Marco Spilotros, Bashir Mukhtar, Mahreen Pakzad, Rizwan Hamid, Jeremy Ockrim, Tamsin Greenwell
OBJECTIVE: Bladder outlet obstruction (BOO) in women remains an underdiagnosed condition. Although diagnosed rarely in general urologic practice, its incidence in specialist centers has been reported to be up to 29%. In the present study we evaluated the incidence of female BOO in adult women referred for evaluation of lower urinary tract symptoms or urinary incontinence, assessing its etiology and correlating this with its clinical presentation. METHODS: The present study consisted of a retrospective review of a prospectively acquired videourodynamic database of 1142 consecutive women referred for evaluation of lower urinary tract symptoms (LUTS) or urinary incontinence from March 2007 to December 2012 and diagnosed with BOO...
October 9, 2017: Lower Urinary Tract Symptoms
https://www.readbyqxmd.com/read/28986626/results-of-transurethral-resection-of-the-prostate-in-renal-transplant-recipients-a-single-center-experience
#3
Mehmet Sarier, Sabri Tekin, İbrahim Duman, Yucel Yuksel, Meltem Demir, Furkan Alptekinkaya, Mehmet Guler, Asuman Havva Yavuz, Alim Kosar
OBJECTIVES: The aim of this study was to retrospectively evaluate the early and long-term results of renal transplantation (RT) patients undergoing transurethral resection of the prostate (TURP) due to benign prostate hyperplasia (BPH). MATERIALS AND METHODS: Eighty-nine patients with RT performed in our hospital underwent TURP between November 2008 and March 2016. Results were evaluated along with early and long-term complications. Patients were followed up for a minimum of 12 months...
October 6, 2017: World Journal of Urology
https://www.readbyqxmd.com/read/28983160/urinary-incontinence-its-risk-factors-and-quality-of-life-a-study-among-women-aged-50-years-and-above-in-a-rural-health-facility-of-west-bengal
#4
Bijit Biswas, Aritra Bhattacharyya, Aparajita Dasgupta, Anubrata Karmakar, Nazrul Mallick, Sembagamuthu Sembiah
CONTEXT: Urinary incontinence (UI) is a chronic debilitating disease which is often under reported, but laid significant impact on one's quality of life (QoL) thus is of public health importance. AIMS: The aim of this study is to find out proportion of rural women have UI, its associated risk factors and treatment-seeking behavior, QoL of affected women. METHODS: This was a cross-sectional clinic-based study conducted from October 2016 to January 2017 among 177 women aged 50 years or above attending a rural health facility with a structured schedule...
July 2017: Journal of Mid-life Health
https://www.readbyqxmd.com/read/28975365/effects-of-urine-alkalinization-with-sodium-bicarbonate-orally-on-lower-urinary-tract-symptoms-in-female-patients-a-pilot-study
#5
Mehmet Giray Sönmez, Yunus Emre Göğer, Gökhan Ecer, Ahmet Atıcı, Mehmet Serkan Özkent, Ahmet Öztürk
INTRODUCTION AND HYPOTHESIS: In this study, we planned to explore the effects of sodium bicarbonate orally (NaHCO3) treatment on female patients with lower urinary tract symptoms (LUTS) who have acidic urine pH values (<6). METHODS: NaHCO3 was given orally to 33 female patients for 4 weeks at a dose of 2 × 4 g/day. Laboratory values, bladder diary, the Patient Perception of Bladder Condition Score (PPBC), Patient Perception of Intensity of Urgency Scale (PPIUS), Overactive Bladder-Validated 8-question Awareness tool (OAB-V8), Pelvic Pain and Urgency & Frequency Patient Symptom Scale tests (PUFSS), and the King's Health Questionnaire (KHQ) scores before and after treatment were compared...
October 3, 2017: International Urogynecology Journal
https://www.readbyqxmd.com/read/28974934/corrigendum-candidate-gene-resequencing-in-a-large-bicuspid-aortic-valve-associated-thoracic-aortic-aneurysm-cohort-smad6-as-an-important-contributor
#6
Elisabeth Gillis, Ajay A Kumar, Ilse Luyckx, Christoph Preuss, Elyssa Cannaerts, Gerarda van de Beek, Björn Wieschendorf, Maaike Alaerts, Nikhita Bolar, Geert Vandeweyer, Josephina Meester, Florian Wünnemann, Russell A Gould, Rustam Zhurayev, Dmytro Zerbino, Salah A Mohamed, Seema Mital, Luc Mertens, Hanna M Björck, Anders Franco-Cereceda, Andrew S McCallion, Lut Van Laer, Judith M A Verhagen, Ingrid M B H van de Laar, Marja W Wessels, Emmanuel Messas, Guillaume Goudot, Michaela Nemcikova, Alice Krebsova, Marlies Kempers, Simone Salemink, Toon Duijnhouwer, Xavier Jeunemaitre, Juliette Albuisson, Per Eriksson, Gregor Andelfinger, Harry C Dietz, Aline Verstraeten, Bart L Loeys
[This corrects the article on p. 400 in vol. 8, PMID: 28659821.].
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28974250/statistical-analysis-plan-for-the-urodynamics-for-prostate-surgery-trial-randomised-evaluation-of-assessment-methods-upstream
#7
Grace J Young, Amanda L Lewis, J Athene Lane, Helen L Winton, Marcus J Drake, Peter S Blair
BACKGROUND: Current management for men with lower urinary tract symptoms (LUTS) is a pathway that results in prostate surgery in a significant proportion. While helpful in relieving benign prostatic obstruction (BPO), surgery may be ineffective for men suffering from difficulties not relating to BPO. The UPSTREAM trial started recruitment in October 2014 with the aim of establishing whether a care pathway including urodynamics (a diagnostic tool for BPO and thus an indication of whether surgery is needed) is no worse for men, in terms of symptomatic outcome, than one without (routine care)...
October 3, 2017: Trials
https://www.readbyqxmd.com/read/28971220/lower-urinary-tract-symptoms-that-predict-microscopic-pyuria
#8
Rajvinder Khasriya, William Barcella, Maria De Iorio, Sheela Swamy, Kiren Gill, Anthony Kupelian, James Malone-Lee
INTRODUCTION AND HYPOTHESIS: Urinary dipsticks and culture analyses of a mid-stream urine specimen (MSU) at 10(5) cfu ml(-1) of a known urinary pathogen are considered the gold standard investigations for diagnosing urinary tract infection (UTI). However, the reliability of these tests has been much criticised and they may mislead. It is now widely accepted that pyuria (≥1 WBC μl(-1)) detected by microscopy of a fresh unspun, unstained specimen of urine is the best biological indicator of UTI available...
October 2, 2017: International Urogynecology Journal
https://www.readbyqxmd.com/read/28967924/a-rational-molecular-design-of-triazine-containing-alkynylplatinum-ii-terpyridine-complexes-and-the-formation-of-helical-ribbons-via-ptpt-%C3%AF-%C3%AF-stacking-and-hydrophobic-hydrophobic-interactions
#9
Heidi Li-Ki Fu, Sammual Yu-Lut Leung, Vivian Wing-Wah Yam
The self-assembly of triazine-containing alkynylplatinum(ii) terpyridine complexes has revealed the formation of sophisticated helical ribbons. Fine control of the morphological transition from plates to helical structures has been demonstrated through an interplay of the bent molecular structure and PtPt, π-π stacking and hydrophobic-hydrophobic interactions.
October 12, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/28967230/prevalence-of-overactive-bladder-in-china-taiwan-and-south-korea-results-from-a-cross-sectional-population-based-study
#10
Yao-Chi Chuang, Shih-Ping Liu, Kyu-Sung Lee, Limin Liao, Jianye Wang, Tag Keun Yoo, Romeo Chu, Budiwan Sumarsono
OBJECTIVE: The aim of the present study was to determine the prevalence of overactive bladder (OAB) in individuals aged ≥40 years in China, Taiwan, and South Korea. METHODS: The present cross-sectional population-representative Internet-based study investigated OAB symptoms in men and women aged ≥40 years using the overactive bladder symptom score. Additional instruments included the International Index of Erectile Function (men only) and the Sexual Quality of Life - Female (women only) questionnaires, as well as Patient Perception of Bladder Condition (PPBC)...
October 2, 2017: Lower Urinary Tract Symptoms
https://www.readbyqxmd.com/read/28965959/lower-urinary-tract-terminology-in-daytime-lower-urinary-tract-symptoms-in-children-a-view-of-the-pediatric-urologist
#11
REVIEW
Marleen van den Heijkant, Guy Bogaert
CONTEXT: Epidemiological studies have demonstrated rates of lower urinary tract (LUT) symptoms in school-aged children as high as 20%. Symptoms of LUT may have significant social consequences. The diagnosis of LUT symptoms in children is mainly based on the subjective impression, and it is therefore important to translate the clinical impression into a structured LUT terminology. OBJECTIVE: To have a view, as a pediatric urologist and a urologist, of the LUT terminology proposed by the Standardization Committee of the International Children Continence Society...
September 28, 2017: European Urology Focus
https://www.readbyqxmd.com/read/28954467/afferent-pathway-mediated-effect-of-%C3%AE-1-adrenergic-antagonist-tamsulosin-on-the-neurogenic-bladder-after-spinal-cord-injury
#12
Jin-Hee Han, Sung-Eun Kim, Il-Gyu Ko, Jayoung Kim, Khae Hawn Kim
PURPOSE: The functions of the lower urinary tract (LUT), such as voiding and storing urine, are dependent on complex central neural networks located in the brain, spinal cord, and peripheral ganglia. Thus, the functions of the LUT are susceptible to various neurologic disorders including spinal cord injury (SCI). SCI at the cervical or thoracic levels disrupts voluntary control of voiding and the normal reflex pathways coordinating bladder and sphincter functions. In this context, it is noteworthy that α1-adrenoceptor blockers have been reported to relieve voiding symptoms and storage symptoms in elderly men with benign prostatic hyperplasia (BPH)...
September 2017: International Neurourology Journal
https://www.readbyqxmd.com/read/28954461/seasonal-changes-in-lower-urinary-tract-symptoms-in-japanese-men-with-benign-prostatic-hyperplasia-treated-with-%C3%AE-1-blockers
#13
Minoru Kobayashi, Akinori Nukui, Takao Kamai
PURPOSE: To investigate whether seasonal changes occurred in lower urinary tract symptoms (LUTS) in patients with benign prostatic hyperplasia (BPH). METHODS: Patients aged 50 years and older with BPH treated with α1-blockers were enrolled. The International Prostate Symptom Score (IPSS), quality of life (QoL) score, maximum and average flow rate, voided volume, and postvoid residual volume were measured in summer and winter. RESULTS: A total of 164 patients were enrolled...
September 2017: International Neurourology Journal
https://www.readbyqxmd.com/read/28954459/clinical-significance-of-periurethral-calcification-according-to-the-location-in-men-with-lower-urinary-tract-symptoms-and-a-small-prostate-volume
#14
Jang Hee Han, Joo Yong Lee, Jong Kyu Kwon, Jong Soo Lee, Kang Su Cho
PURPOSE: To assess the impact of periurethral calcification (PUC) according to its location on uroflowmetric parameters and urinary symptoms in patients with small prostate volume (PV). METHODS: Records were obtained from a prospectively maintained database of first-visit men with lower urinary tract symptoms (LUTS). Patients whose PV was >30 mL were excluded to elucidate more clearly the impact of PUC on LUTS. A total of 539 patients were enrolled in the study...
September 2017: International Neurourology Journal
https://www.readbyqxmd.com/read/28952690/-efficacy-of-tamsulosin-for-treating-lower-urinary-tract-symptoms-in-patients-with-advanced-prostate-cancer
#15
A V Govorov, A O Vasilyev, D Yu Pushkar
RELEVANCE: From the moment of their first use to the present day, -adrenoblockers remain the most popular medication in urology. Indications for their clinical use for various pathological conditions are constantly expanding. AIM: To compare the efficacy of androgen deprivation therapy (ADT) alone and ADT with concomitant use of tamsulosin in treating lower urinary tract symptoms (LUTS), and to estimate the efficacy and safety of tamsulosin in relieving voiding dysfunction symptoms in patients with advanced PCa treated for 6 months...
September 2017: Urologii︠a︡
https://www.readbyqxmd.com/read/28950889/urinary-bowel-and-sexual-symptoms-in-a-cohort-of-patients-with-friedreich-s-ataxia
#16
Meher Lad, Michael H Parkinson, Myriam Rai, Massimo Pandolfo, Petya Bogdanova-Mihaylova, Richard A Walsh, Sinéad Murphy, Anton Emmanuel, Jalesh Panicker, Paola Giunti
BACKGROUND: Pelvic symptoms are distressing symptoms experienced by patients with Friedreich's Ataxia (FRDA). The aim of this study was to describe the prevalence of lower urinary tract symptoms (LUTS), bowel and sexual symptoms in FRDA. METHODS: Questionnaire scores measuring LUTS, bowel and sexual symptoms were analysed with descriptive statistics as a cohort and as subgroups (Early/Late-onset and Early/Late-stage FRDA) They were also correlated with validated measures of disease severity including those of ataxia severity, non-ataxic symptoms and activities of daily living...
September 26, 2017: Orphanet Journal of Rare Diseases
https://www.readbyqxmd.com/read/28945275/collagen-content-in-the-bladder-of-men-with-luts-undergoing-open-prostatectomy-a-pilot-study
#17
Marcio A Averbeck, Nelson G De Lima, Gabriela A Motta, Lauro F Beltrao, Nury J Abboud Filho, Clarice P Rigotti, William N Dos Santos, Steven K J Dos Santos, Luis F B Da Silva, Ernani L Rhoden
AIMS: To evaluate the collagen content in the bladder wall of men undergoing open prostate surgery. METHODS: From July 2014 to August 2016, men aged ≥ 50 years, presenting LUTS and undergoing open prostate surgery due to benign prostatic enlargement (BPE) or prostate cancer were prospectively enrolled. Preoperative assessment included validated questionnaires (IPSS and OAB-V8), lower urinary tract ultrasound, and urodynamics. Bladder biopsies were obtained during open prostatectomy for determination of collagen content (sirius red-picric acid stain; polarized light analysis)...
September 25, 2017: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/28941035/role-of-estrogen-receptor-alpha-and-beta-in-bladder-tissue-in-patients-with-clinical-diagnosis-of-benign-prostatic-hyperplasia
#18
R Bhattar, S S Yadav, V Tomar, A Mittal, G Gangkak, J Mehta
OBJECTIVE: To study the differential expression of estrogen receptor (ER) subtypes in human urinary bladder tissue using immunohistochemistry (IHC) methods and explores their correlation with various measures of LUTS. METHODS: In this prospective case control study, case group (group A) comprised of 34 patients having bothersome LUTS underwent transurethral resection of prostate (TURP). 19 age matched otherwise normal patients who underwent cystoscopy as an investigation for microscopic hematuria were categorized in control group (group B)...
September 21, 2017: BJU International
https://www.readbyqxmd.com/read/28937771/urinary-metabolic-phenotyping-of-women-with-lower-urinary-tract-symptoms
#19
Rhiannon Bray, Stefano Cacciatore, Beatriz Jimenez, Rufus Cartwright, Alex Digesu, Ruwan Fernando, Elaine Holmes, Jeremy Kirk Nicholson, Phillip R Bennett, David A MacIntyre, Vik Khullar
Lower urinary tract symptoms (LUTS), including urinary incontinence, urgency and nocturia, affect approximately half of women worldwide. Current diagnostic methods for LUTS are invasive and costly, while available treatments are limited by side effects leading to poor patient compliance. In this study, we aimed to identify urine metabolic signatures associated with LUTS using proton nuclear magnetic resonance ((1)H-NMR) spectroscopy. A total of 214 urine samples were collected from women attending tertiary urogynaecology clinics (cases; n=176) and healthy control women attending general gynecology clinics (n=36)...
September 22, 2017: Journal of Proteome Research
https://www.readbyqxmd.com/read/28933094/-protective-effects-of-luteolin-against-acetaminophen-induced-damage-in-l02-liver-cells
#20
Lan-Zhi He, Ya-Kun Meng, Yan-Zhong Han, Zhen-Fang Zhang, Ping Yin, Xiu-Xiu Sang, Xiao-He Xiao, Zhao-Fang Bai
This paper was aimed to investigate the protective effects of luteolin (Lut) against acetaminophen(APAP)-induced damage in L02 liver cells. CCK-8 was used to detect the cell activation of L02 cells treated by different Lut. The concentration and time of APAP induced L02 cell damage was screened. The effect of Lut on APAP induced apoptosis of L02 cells was detected by cell morphological observation, CCK-8 assay and flow cytometry. The contents of MDA, GSH and SOD activity in cell supernatant were detected by colorimetric assay...
November 2016: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
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