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https://www.readbyqxmd.com/read/29452392/pbrit-gene-prioritization-by-correlating-functional-and-phenotypic-annotations-through-integrative-data-fusion
#1
Ajay Anand Kumar, Lut Van Laer, Maaike Alaerts, Amin Ardeshirdavani, Yves Moreau, Kris Laukens, Bart Loeys, Geert Vandeweyer, Inanc Birol
Motivation: Computational gene prioritization can aid in disease gene identification. Here, we propose pBRIT (prioritization using Bayesian Ridge regression and Information Theoretic model), a novel adaptive and scalable prioritization tool, integrating Pubmed abstracts, Gene Ontology, Sequence similarities, Mammalian and Human Phenotype Ontology, Pathway, Interactions, Disease Ontology, Gene Association database and Human Genome Epidemiology database, into the prediction model.We explore and address effects of sparsity and inter-feature dependencies within annotation sources, and the impact of bias towards specific annotations...
February 14, 2018: Bioinformatics
https://www.readbyqxmd.com/read/29450732/combined-prostatic-urethral-lift-and-remodeling-of-the-prostate-and-bladder-neck-a-modified-transurethral-approach-in-the-treatment-of-symptomatic-lower-urinary-tract-obstruction
#2
Martin Schoenthaler, Karl-Dietrich Sievert, Dominik Stefan Schoeb, Arkadiusz Miernik, Thomas Kunit, Simon Hein, Thomas R W Herrmann, Konrad Wilhelm
PURPOSE: The aim of the study was to evaluate the feasibility and safety of combining prostatic urethral lift (PUL) and a limited resection of the prostatic middle lobe or bladder neck incision in the treatment of lower urinary tract symptoms (LUTS) secondary to benign prostatic hyperplasia (BPH). METHODS: Twenty-eight patients were treated at two tertiary centers and followed prospectively. Patient evaluations included patient characteristics, relief of LUTS symptoms, erectile and ejaculatory function, continence, operative time and adverse events...
February 15, 2018: World Journal of Urology
https://www.readbyqxmd.com/read/29449167/what-s-new-in-epidemiology
#3
REVIEW
Sachin Malde, Rufus Cartwright, Kari A O Tikkinen
There have been a number of recent advances in the epidemiological study of male lower urinary tract symptoms (LUTS). Here, we have reviewed the most novel and important literature. Studies assessing the risk factors, natural history as well as impact of male LUTS are included, focussing on recent progress in the field.
February 12, 2018: European Urology Focus
https://www.readbyqxmd.com/read/29445269/an-open-label-prospective-interventional-study-of-the-tolerability-and-efficacy-of-0-4-mg-oral-tamsulosin-oral-controlled-absorption-system-in-men-with-lower-urinary-tract-symptoms-associated-with-benign-prostatic-hyperplasia-who-are-unsatisfied-with-treatment
#4
Pei-Shan Yang, Chien-Lun Chen, Chen-Pang Hou, Yu-Hsiang Lin, Ke-Hung Tsui
Purpose: The aim of this study was to investigate the efficacy and tolerability of switching from 0.2 mg tamsulosin to 0.4 mg tamsulosin oral controlled absorption system (OCAS) over a 12-week period in Taiwanese men with lower urinary tract symptoms (LUTS) associated with benign prostatic hyperplasia (BPH). Patients and methods: Taiwanese male patients who were dissatisfied with treatment with 0.2 mg tamsulosin were enrolled in this clinical study and switched to 0...
2018: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/29434675/best-practice-in-the-management-of-storage-symptoms-in-male-lower-urinary-tract-symptoms-a-review-of-the-evidence-base
#5
REVIEW
Mauro Gacci, Arcangelo Sebastianelli, Pietro Spatafora, Giovanni Corona, Sergio Serni, Dirk De Ridder, Stavros Gravas, Paul Abrams
Storage lower urinary tract symptoms (LUTS) are characterized by an altered bladder sensation, increased daytime frequency, nocturia, urgency and urgency incontinence. Some evidence underlines the role of metabolic factors, pelvic ischemia, prostatic chronic inflammation and associated comorbidities in the pathophysiology of storage LUTS. A detailed evaluation of the severity of storage LUTS, and the concomitance of these symptoms with voiding and postmicturition symptoms, is mandatory for improving the diagnosis and personalizing treatment...
February 2018: Therapeutic Advances in Urology
https://www.readbyqxmd.com/read/29432226/combination-treatment-for-male-lower-urinary-tract-symptoms-with-anticholinergic-and-alpha-blockers
#6
Alex Gomelsky, Emily F Kelly, David C Dalton
PURPOSE OF REVIEW: Although alpha-adrenergic antagonists (α-blockers) are effective for relieving voiding lower urinary tract symptoms (LUTS) in men, storage symptoms often persist. The aim of this manuscript is to evaluate the efficacy and safety of combination therapy with α-blockers and muscarinic receptor antagonists (anticholinergics). RECENT FINDINGS: High-quality evidence confirms that the addition of an anticholinergic improves micturition diary parameters, such as daytime and nocturnal frequency and urgency incontinence episodes, as well as total and storage subset scores on the International Prostate Symptom Score...
February 9, 2018: Current Opinion in Urology
https://www.readbyqxmd.com/read/29428929/improvements-in-self-reported-lower-urinary-tract-symptoms-with-prostate-health-supplement
#7
Isaac Eliaz, Elaine Weil, Barry Wilk
Context • Benign prostatic hyperplasia (BPH) produces lower urinary tract symptoms (LUTS) that diminish quality of life. Conventional treatments are often accompanied by adverse side effects. By contrast, consumers of phytochemicals-based dietary supplements often report a reduction in symptoms without side effects. The field needs studies that quantify the strength and character of perceived benefits. Objectives • The study intended to quantify the character and strength of perceived improvements in LUTS in men, after the consumption of a prostate health supplement...
February 10, 2018: Alternative Therapies in Health and Medicine
https://www.readbyqxmd.com/read/29428420/diagnosis-and-treatment-of-male-patients-with-lower-urinary-tract-symptoms-in-spain-the-mercury-study-do-urologists-follow-the-recommendations-of-the-european-guidelines
#8
C Errando-Smet, C Müller-Arteaga, M Hernández, M Roset
OBJECTIVES: To explore the management of lower urinary tract symptoms(LUTS) in men in Spain and assess the compliance with recommendationsestablished in the European Association of Urology (EAU) guidelines. MATERIAL AND METHODS: MERCURY was an epidemiological and cross-sectionalstudy which involved 227 Urology Units across Spain assessing adult malepatients with mixed LUTS and persisting storage symptoms.Sociodemographic, clinical and resource use data for the 6 months priorto study inclusion were collected...
February 7, 2018: Actas Urologicas Españolas
https://www.readbyqxmd.com/read/29427214/pharmacotherapy-for-nocturia
#9
REVIEW
Karl-Erik Andersson, Philip Van Kerrebroeck
PURPOSE OF REVIEW: To assess current pharmacological principles used for treatment of nocturia/nocturnal polyuria. RECENT FINDINGS: The pathophysiology of nocturia is often multifactorial, but two main mechanisms have been identified, occurring alone or in combination: low functional bladder capacity and nocturnal polyuria. The multifactorial pathophysiology not only implies several possible targets for therapeutic intervention but also means that it is unlikely that one treatment modality including drugs will be successful in all patients...
February 9, 2018: Current Urology Reports
https://www.readbyqxmd.com/read/29422390/novel-naftopidil-derivatives-containing-methyl-phenylacetate-and-their-blocking-effects-on-%C3%AE-1d-1a-adrenoreceptor-subtypes
#10
Jun-Jun Huang, Zhi-Han Zhang, Fei He, Xia-Wen Liu, Xing-Jie Xu, Li-Jun Dai, Qi-Meng Liu, Mu Yuan
α1-Adrenoceptor (α1-AR) antagonists are considered to be the most effective monotherapy agents for lower urinary tract symptoms associated with benign prostatic hyperplasia (LUTS/BPH). In this study, we synthesized compounds 2-17, which are novel piperazine derivatives that contain methyl phenylacetate. We then evaluated the vasodilatory activities of these compounds. Among them, we found that compounds 2, 7, 12, which contain 2-OCH3, 2-CH3 or 2, 5-CH3, respectively, exhibited potent α1-blocking activity similar to protype drug naftopidil (1)...
February 5, 2018: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/29421780/luteolin-modulates-serca2a-leading-to-attenuation-of-myocardial-ischemia-reperfusion-injury-via-sumoylation-at-lysine-585-in-mice
#11
Yinping Du, Ping Liu, Tongda Xu, Defeng Pan, Hong Zhu, Nana Zhai, Yanbin Zhang, Dongye Li
BACKGROUND/AIMS: The myocardial sarcoplasmic reticulum calcium ATPase (SERCA2a) is a pivotal pump responsible for calcium cycling in cardiomyocytes. The present study investigated the effect of luteolin (Lut) on restoring SERCA2a protein level and stability reduced by myocardial ischemia/reperfusion (I/R) injury. We verified a hypothesis that Lut protected against myocardial I/R injury by regulating SERCA2a SUMOylation. METHODS: The hemodynamic data, myocardial infarct size of intact hearts, apoptotic analysis, mitochondrial membrane potential (ΔΨm), the level of SERCA2a SUMOylation, and the activity and expression of SERCA2a were examined in vivo and in vitro to clarify the cardioprotective effects of Lut after SUMO1 was knocked down or over-expressed...
February 2, 2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29419682/acupuncture-for-management-of-lower-urinary-tract-symptoms-in-parkinson-s-disease-a-protocol-for-the-systematic-review-of-randomized-controlled-trials
#12
Jong-In Kim, Tae-Young Choi, Ji Hee Jun, Hee Kang, Myeong Soo Lee
BACKGROUND: Acupuncture is claimed to improve the lower urinary tract symptoms (LUTS). Currently, no systematic reviews are performed for acupuncture on LUTS in patients with Parkinson's diseases (PD). This review aims to evaluate the current evidence on the efficacy of acupuncture for the management of LUTS in PD. METHODS AND ANALYSES: Eleven databases will be searched from their inception. These include PubMed, AMED, EMBASE, the Cochrane Library, 6 Korean medical databases, and 1 Chinese medical database...
February 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29410322/characterizing-clinically-meaningful-changes-in-lower-urinary-tract-symptoms-using-the-american-urologic-association-symptom-index
#13
Thomas W Fuller, Benjamin T Ristau, Sarah M Tepe, Ronald M Benoit
OBJECTIVES: To correlate patient perception of changes in their lower urinary tract symptoms (LUTS) with changes in their American Urological Association Symptom Index score (AUA-SI) with the goal of improving the ability of patients and clinicians to assess the clinical meaningfulness of changes in the AUA-SI. METHODS: Men were asked to complete an AUA-SI survey and answer a symmetrical response framework question to evaluate their global perception of change in LUTS at each interval: namely, "are your urinary symptoms much better, slightly better, the same, slightly worse, or much worse compared to your prior visit?" Median changes and interquartile ranges (IQR) in the AUA-SI were compared to the global evaluation response for the entire cohort...
February 1, 2018: Urology
https://www.readbyqxmd.com/read/29409344/experiences-of-stigma-and-discrimination-in-social-and-healthcare-settings-among-trans-people-living-with-hiv-in-the-uk
#14
M Hibbert, A Wolton, W Crenna-Jennings, L Benton, P Kirwan, I Lut, S Okala, M Ross, M Furegato, K Nambiar, N Douglas, J Roche, J Jeffries, I Reeves, M Nelson, C Weerawardhana, Z Jamal, A Hudson, V Delpech
The People Living with HIV StigmaSurvey UK 2015 was a community led national survey investigating experiences of people living with HIV in the UK in the past 12 months. Participants aged 18 and over were recruited through over 120 cross-sector community organisations and 46 HIV clinics to complete an anonymous online survey. Trans is an umbrella term which refers to individuals whose current gender identity is different to the gender they were assigned at birth. Trans participants self-identified via gender identity and gender at birth questions...
February 6, 2018: AIDS Care
https://www.readbyqxmd.com/read/29408214/the-relationship-between-sleep-disorders-and-lower-urinary-tract-symptoms-results-from-the-national-health-and-nutrition-examination-survey-nhanes
#15
Richard J Fantus, Vignesh T Packiam, Chi H Wang, Bradley A Erickson, Brian T Helfand
PURPOSE: It is well established that sleep disorders (SDs) are associated with the prevalence of nocturia in men. While previous literature supports that patients with SDs are at increased risk of nocturia, the risk of daytime lower urinary tract symptoms (LUTS) has not been well established. MATERIALS AND METHODS: We examined the National Health and Nutrition Examination Survey (NHANES) database between 2006-2008. Men over the age of 40 who completed the sleep, prostate and kidney questionnaires were included in the study...
February 2, 2018: Journal of Urology
https://www.readbyqxmd.com/read/29406059/lower-urinary-tract-symptoms-benign-prostatic-hyperplasia-and-urinary-retention
#16
REVIEW
Omar Al Hussein Alawamlh, Ramy Goueli, Richard K Lee
Lower urinary tract symptoms (LUTS) consist of a common set of urologic symptoms that can affect the elderly. The prevalence of LUTS is expected to rise owing to the continued increase of numbers of the elderly. Although benign prostatic hyperplasia is considered a common cause of LUTS, the broader potential causes of LUTS are myriad. A wide range of diagnostic modalities and treatments are available to manage patients with LUTS and their utilization should not be limited to the urologist.
March 2018: Medical Clinics of North America
https://www.readbyqxmd.com/read/29405593/severe-prostate-enlargement-with-severe-lower-urinary-tract-symptoms-in-poorly-controlled-acromegaly-successfully-treated-with-5%C3%AE-reductase-inhibitors-a-15-year-longitudinal-case-report
#17
Yu-Chen Chen, Hao-Wei Chen, Ming-Tan Chen, Chun-Hsiung Huang, Ching-Chia Li, Yung-Shun Juan, Hung-Lung Ke
Acromegaly is a rare disease associated with an increased risk of prostate enlargement. Severe prostate enlargement with severe lower urinary tract symptoms (LUTS) in an acromegalic patient is even more uncommon. Herein we report on a 55-year-old man who was diagnosed with acromegaly and prostate enlargement at 40 years of age. Transsphenoidal surgery, postoperative radiotherapy, and octreotide medical therapy failed to control the acromegaly, and growth hormone (GH) and insulin-like growth factor 1 (IGF-1) levels remained elevated...
February 5, 2018: Lower Urinary Tract Symptoms
https://www.readbyqxmd.com/read/29399926/the-choice-between-deceased-vs-living-donor-renal-transplantation-in-children-analysis-of-data-from-a-belgian-tertiary-center
#18
Katty Van Cauwenberghe, Ann Raes, Lut Pauwels, Jo Dehoorne, Luc Colenbie, Clement Dequidt, Lien Dossche, Johan Vande Walle, Agnieszka Prytuła
Pediatric renal transplantation with a living donor (LD) has superior outcome, but there is a paucity of studies analyzing the reasons for not undertaking living donation in West-European countries. The aim of this study was to retrospectively review the choice of donor source in our center. We also aimed to identify factors which prevented transplantation with a LD. This retrospective study was performed including children aged 2-19 years who underwent kidney transplantation (KT) at the Ghent University Hospital between 1996 and 2016...
February 4, 2018: Pediatric Transplantation
https://www.readbyqxmd.com/read/29394926/intravescical-prostatic-protrusion-is-a-predictor-of-alpha-blockers-response-results-from-an-observational-study
#19
L Topazio, C Perugia, C De Nunzio, G Gaziev, V Iacovelli, D Bianchi, G Vespasiani, E Finazzi Agrò
BACKGROUND: To investigate the efficacy of tamsulosin in patients with lower urinary tract symptoms (LUTS) and benign prostatic enlargement (BPE) with intravesical prostatic protrusion (IPP). Ultrasound measurement of the IPP has been previously described as an effective instrument for the evaluation of benign prostatic obstruction (BPO) and could help in clarifying the role of alpha-blockers in patients with (BPE). METHODS: Patients with BPE and LUTS were enrolled in this observational study...
February 2, 2018: BMC Urology
https://www.readbyqxmd.com/read/29394114/efficacy-of-newer-medications-for-lower-urinary-tract-symptoms-attributed-to-benign-prostatic-hyperplasia-a-systematic-review
#20
Roderick MacDonald, Michelle Brasure, Philipp Dahm, Carin M Olson, Victoria A Nelson, Howard A Fink, Michael C Risk, Bruce Rwabasonga, Timothy J Wilt
We conducted a systematic review to evaluate the efficacy and adverse effects of newer drugs used to treat lower urinary tract symptoms (LUTS). The drugs were either Food and Drug Administration (FDA) approved for benign prostatic hyperplasia (BPH) or not FDA approved for BPH but have been evaluated for treatment of BPH since 2008. We searched bibliographic databases through September 2017. We included randomized controlled trials (RCTs) lasting one month or longer published in English. Outcomes of interest were LUTS assessed by validated measures...
February 2, 2018: Aging Male: the Official Journal of the International Society for the Study of the Aging Male
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