keyword
MENU ▼
Read by QxMD icon Read
search

Luts

keyword
https://www.readbyqxmd.com/read/29232160/microrna-145-antagonism-reverses-tgf-%C3%AE-inhibition-of-f508del-cftr-correction-in-airway-epithelia
#1
Farruk Lutful Kabir, Namasivayam Ambalavanan, Gang Liu, Peng Li, George M Solomon, Charitharth V Lal, Marina Mazur, Brian Halloran, Tomasz Szul, William T Gerthoffer, Steven M Rowe, William T Harris
INTRODUCTION: microRNAs (miRNAs) destabilize mRNA transcripts and inhibit protein translation. miR-145 is of particular interest in cystic fibrosis (CF) as it has a direct binding site in the 3'-untranslated region of CFTR and is upregulated by the CF genetic modifier TGF-β. HYPOTHESIS: miR-145 mediates TGF-β inhibition of CFTR synthesis and function in airway epithelia. METHODS: Primary human CF (F508del homozygous) and non-CF airway epithelial cells (AECs) were grown to terminal differentiation at air-liquid interface on permeable supports...
December 12, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/29231747/practice-patterns-to-improve-pre-and-post-transplant-medication-adherence-in-heart-transplant-centres-a-secondary-data-analysis-of-the-international-bright-study
#2
Yuliya Senft, Monika Kirsch, Kris Denhaerynck, Fabienne Dobbels, Remon Helmy, Cynthia L Russell, Lut Berben, Sabina De Geest
BACKGROUND: As medication non-adherence is a major risk factor for poor post-transplant outcomes, we explored how adherence is assessed, enhanced and integrated across the transplant continuum. AIM: The aim of this study was to study practice patterns regarding pre- and post-transplant medication adherence assessment and interventions in international heart transplant centres. METHODS: We used data from the Building Research Initiative Group: chronic illness management and adherence in heart transplantation (BRIGHT) study, a cross-sectional study conducted in 36 heart transplant centres in 11 countries...
December 1, 2017: European Journal of Cardiovascular Nursing
https://www.readbyqxmd.com/read/29228847/comparison-of-the-effectiveness-of-ipss-and-vpss-without-any-help-in-luts-patients-a-prospective-study
#3
Muhammet Guzelsoy, Mustafa Murat Aydos, Soner Coban, Ali Riza Turkoglu, Kadir Acibucu, Hakan Demirci
AIM: To compare the correlation of visual prostate symptom score (VPSS) and international prostate symptom score (IPSS). To investigate the effect of educational level and age in the responses to VPSS and IPSS. METHOD: Three hundred and nine patients who gave consent and applied via LUTS to our institution were included in this study. They were requested to fill IPSS and VPSS. The patients were divided into two groups as middle-aged and elderly with a cutoff point of 65 years...
December 11, 2017: Aging Male: the Official Journal of the International Society for the Study of the Aging Male
https://www.readbyqxmd.com/read/29223674/prediction-of-need-for-intervention-in-posterior-urethral-valves-use-of-urine-osmolality
#4
Anna E Wright, Ruth Wragg, Joana Lopes, Andrew Robb, Liam McCarthy
AIM: Renal tubular dysfunction (RTD) causing obligate production of hypoosmolar urine in boys with posterior urethral valves (PUVs) has been described. It is not known how clinically significant this is. We hypothesize that a feedback loop is present in many PUV boys who suffer deterioration of their lower urinary tract (LUT). RTD results in hypoosmolar urine, obligate polyuria, and bladder stretch-injury. The increasing back-pressure worsens RTD, thus exacerbating the injury. Coexisting renal dysplasia and acquired renal scarring exacerbate this...
November 14, 2017: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/29215107/%C3%AE-carotene-bioaccessibility-from-biofortified-maize-zea-mays-is-related-to-its-density-and-is-negatively-influenced-by-lutein-and-zeaxanthin
#5
Nivedita Dube, Purna Chandra Mashurabad, Firoz Hossain, Raghu Pullakhandam, Longvah Thingnganing, Dinesh Kumar Bharatraj
Biofortification of maize with provitamin A (pro-VA) carotenoids has been successful, but the bioavailability of carotenoids needs to be explored. In the present study, we investigated the carotenoid content, micellarization and intestinal cell uptake of carotenoids from 10 maize hybrids [normal maize, quality protein maize (QPM), pro-VA carotenoid and double biofortified QPM + pro-VA maize hybrids] using a simulated in vitro digestion/Caco-2 cell model. The pro-VA carotenoid content of biofortified maize hybrids is 2-10 fold higher compared to that of normal maize...
December 7, 2017: Food & Function
https://www.readbyqxmd.com/read/29207088/liposome-encapsulated-luteolin-showed-enhanced-antitumor-efficacy-to-colorectal-carcinoma
#6
Guixia Wu, Jing Li, Jinqiao Yue, Shuying Zhang, Kurexi Yunusi
Luteolin is a falconoid compound that is present in various types of plants and possesses remarkable potential as a chemopreventive agent. However, the poor aqueous solubility of luteolin limits its clinical application. In the present study, an approach towards chemoprevention was explored using liposomes to deliver luteolin, and the antitumor efficacy was investigated in colorectal carcinoma. The present findings demonstrated that luteolin was efficiently encapsulated into liposomes with an encapsulation efficiency as high as 90%...
November 29, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29205855/multi-level-factors-are-associated-with-immunosuppressant-nonadherence-in-heart-transplant-recipients-the-international-bright-study
#7
Kris Denhaerynck, Lut Berben, Fabienne Dobbels, Cynthia L Russell, Marisa G Crespo-Leiro, Alain Jean Poncelet, Sabina De Geest
Factors at the level of family/healthcare worker-, organization- and system are neglected in medication nonadherence research in heart transplantation (HTx). The four-continent, eleven-country cross-sectional BRIGHT study used multi-staged sampling to examine 36 HTx centers, including 36 HTx directors, 100 clinicians, and 1397 patients. Nonadherence to immunosuppressants-defined as any deviation in taking or timing adherence and/or dose reduction-was assessed using the BAASIS® interview. Guided by the Integrative Model of Behavioral Prediction and Bronfenbrenner's ecological model, we analyzed factors at these multiple levels using sequential logistic regression analysis (6 blocks)...
December 5, 2017: American Journal of Transplantation
https://www.readbyqxmd.com/read/29203892/metabolic-syndrome-and-smoking-are-associated-with-an-increased-risk-of-nocturia-in-male-patients-with-benign-prostatic-enlargement
#8
Cosimo De Nunzio, Aldo Brassetti, Flavia Proietti, Marianna Deroma, Francesco Esperto, Andrea Tubaro
BACKGROUND: To evaluate the relationship between cigarette smoking, metabolic syndrome (MetS) and nocturia in patients with lower urinary tract symptoms (LUTS) and benign prostatic enlargement (BPE). METHODS: From 2009 onward, a consecutive series of patients with LUTS/BPE were enrolled. Symptoms were assessed using the International Prostate Symptom Score (IPSS). Age, body mass index (BMI), smoker status, prostate volume (PV), prostate-specific antigen (PSA) levels, fasting glucose levels, triglyceride levels, and high-density lipoprotein levels were recorded...
December 4, 2017: Prostate Cancer and Prostatic Diseases
https://www.readbyqxmd.com/read/29199881/phytochylomicron-as-a-dual-nanocarrier-for-liver-cancer-targeting-of-luteolin-in-vitro-appraisal-and-pharmacodynamics
#9
Yosra Sr Elnaggar, Manal A Elsheikh, Ossama Y Abdallah
AIM: A novel luteolin (LUT) loaded dual bionanocarrier 'phytochylomicron' was elaborated to allow LUT injectable delivery and liver cancer targeting. METHODS: LUT-phospholipid complex was prepared and loaded into chylomicron nanocarrier. Then phytochylomicron underwent physicochemical characterization, cell culture and pharmacodynamics studies on a new liver-tumor model. RESULTS: Phytochylomicron showed sustained release pattern with minimum drug leakage until reaching the liver...
December 4, 2017: Nanomedicine
https://www.readbyqxmd.com/read/29199000/research-needs-to-understand-self-management-in-men-with-luts-a-review-and-summary-of-an-niddk-workshop
#10
EDITORIAL
Jenna M Norton, Tamara G Bavendam, William Elwood, Steven J Jacobsen, Steven A Kaplan, John W Kusek, Yining Xie, Robert A Star, Ziya Kirkali
Lower urinary tract symptoms (LUTS) are common in men and impose significant economic, health and quality of life burdens. Despite an expanding view of LUTS etiology and challenges with medical and surgical treatments, LUTS research has continued to focus primarily on surgical or pharmaceutical treatment of urinary tract dysfunction, with little attention to behavioral, cognitive, or social factors. Further, self-management research is relatively underdeveloped in urology, despite its potential to support behavioral, pharmacologic, and surgical treatments for LUTS...
November 30, 2017: Journal of Urology
https://www.readbyqxmd.com/read/29197737/mid-infrared-pulsed-laser-ultrasonic-testing-for-carbon-fiber-reinforced-plastics
#11
Masahiro Kusano, Hideki Hatano, Makoto Watanabe, Shunji Takekawa, Hisashi Yamawaki, Kanae Oguchi, Manabu Enoki
Laser ultrasonic testing (LUT) can realize contactless and instantaneous non-destructive testing, but its signal-to-noise ratio must be improved in order to measure carbon fiber reinforced plastics (CFRPs). We have developed a mid-infrared (mid-IR) laser source optimal for generating ultrasonic waves in CFRPs by using a wavelength conversion device based on an optical parametric oscillator. This paper reports a comparison of the ultrasonic generation behavior between the mid-IR laser and the Nd:YAG laser. The mid-IR laser generated a significantly larger ultrasonic amplitude in CFRP laminates than a conventional Nd:YAG laser...
November 24, 2017: Ultrasonics
https://www.readbyqxmd.com/read/29194544/numbers-systems-people-how-interactions-influence-integration-insights-from-case-studies-of-hiv-and-reproductive-health-services-delivery-in-kenya
#12
Susannah H Mayhew, Sedona Sweeney, Charlotte E Warren, Martine Collumbien, Charity Ndwiga, Richard Mutemwa, Irina Lut, Manuela Colombini, Anna Vassall
Drawing on rich data from the Integra evaluation of integrated HIV and reproductive-health services, we explored the interaction of systems hardware and software factors to explain why some facilities were able to implement and sustain integrated service delivery while others were not. This article draws on detailed mixed-methods data for four case-study facilities offering reproductive-health and HIV services between 2009 and 2013 in Kenya: (i) time-series client flow, tracking service uptake for 8841 clients; (ii) structured questionnaires with 24 providers; (iii) in-depth interviews with 17 providers; (iv) workload and facility data using a periodic activity review and cost-instruments; and (v) contextual data on external activities related to integration in study sites...
November 1, 2017: Health Policy and Planning
https://www.readbyqxmd.com/read/29191671/erectile-dysfunction-and-lower-urinary-tract-symptoms
#13
REVIEW
Cosimo De Nunzio, Claus G Roehrborn, Karl-Erik Andersson, Kevin T McVary
CONTEXT: Lower urinary tract symptoms (LUTSs) and erectile dysfunction (ED) are substantial health concerns with a significant impact on the overall male quality of life. OBJECTIVE: To evaluate the available evidence of the association between LUTSs and ED in patients with benign prostatic hyperplasia (BPH), and discuss possible clinical implications for the management of LUTS/BPH. EVIDENCE ACQUISITION: A systematic review of the existing literature published between 1997 and June 2017 and available in the Medline, Scopus, and Web of Science databases was conducted using both the Medical Subject Heading (MeSH) and free-text protocols...
November 27, 2017: European Urology Focus
https://www.readbyqxmd.com/read/29188203/comparison-of-visual-prostate-symptom-score-and-international-prostate-symptom-score-in-the-evaluation-of-men-with-benign-prostatic-hyperplasia-a-prospective-study-from-an-indian-population
#14
Yogesh Taneja, Priyatama Ram, Satish Kumar, Kishan Raj, Charan K Singh, Santosh K Dhaked, Jiten Jaipuria
Background: Lower urinary tract symptoms (LUTSs) due to benign prostatic hyperplasia (BPH) are common conditions in middle-age or older men. The International Prostate Symptom Score (IPSS) is a useful and validated questionnaire to evaluate LUTS secondary to BPH. Van der Walt et al have developed an alternative questionnaire named the Visual Prostate Symptom Score (VPSS) questionnaire. This study aimed to evaluate the relationship between the VPSS and IPSS in the evaluation of men with LUTSs due to BPH in an Indian population...
December 2017: Prostate International
https://www.readbyqxmd.com/read/29175111/metabolomics-approach-for-male-lower-urinary-tract-symptoms-an-identification-of-possible-biomarkers-and-potential-targets-for-new-treatments
#15
Takahiko Mitsui, Satoru Kira, Tatsuya Ihara, Norifumi Sawada, Hiroshi Nakagomi, Tatsuya Miyamoto, Hiroshi Shimura, Hiroshi Yokomichi, Masayuki Takeda
OBJECTIVES: We identified metabolites using a metabolomics approach and investigated the association between these metabolites and lower urinary tract symptoms (LUTS). METHODS: A 24-hr bladder diary and International Prostate Symptom Score (IPSS) were used to assess micturition behaviors and LUTS in a total of 58 male patients without apparent neurological diseases. LUTS was defined as a total IPSS score of ≥8 (the LUTS-group), while patients with a score of <7 were placed in the Control-group...
November 21, 2017: Journal of Urology
https://www.readbyqxmd.com/read/29169376/the-mediating-factors-in-the-relationship-between-lower-urinary-tract-symptoms-and-health-related-quality-of-life
#16
Weng-Yee Chin, Edmond P H Choi, Eric Y F Wan, Cindy L K Lam
OBJECTIVES: An earlier study found that mental health partially mediates the relationship between lower urinary tract symptoms (LUTS) severity and health-related quality of life (HRQOL). In other words, LUTS adversely affects mental health, which in turn adversely affects HRQOL. A major limitation of the previous study was its cross-sectional design. The aim of this study is to evaluate whether changes in mental health mediated the association between changes in the severity of LUTS and changes in HRQOL over 24 months by using Baron and Kenny's regression procedure and Preacher and Hayes's bootstrapping method...
November 23, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/29168235/effects-of-nutraceuticals-on-sexual-satisfaction-and-lower-urinary-tract-symptoms-in-a-cohort-of-young-old-men
#17
Anna Perri, Alessandro Ilacqua, Marina Valenti, Antonio Aversa
The aim of this study was to evaluate the effects of nutraceuticals containing multiple supplemental facts (Virherbe®/Rekupros®) on sexual satisfaction and lower urinary tract symptoms (LUTS) in young-old men. In an open-label trial, 40 males (mean age 66 ± 13) with sexual disturbances and mild LUTS but without cognitive/motor impairment and clinical hypogonadism were enrolled. Sexual desire (SD; IIEF-SD domain) and satisfaction (Global Assessment Question; GAQ), the capacity to perform daily activities (evaluated by 6-min walking test [6MWT]), and International Prostate Symptoms Scores (IPSS) were evaluated before and after oral administration of 2 capsules/day of each supplement for 8 weeks...
November 23, 2017: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/29164564/role-of-silodosin-in-patients-with-luts-bpe-non-responding-to-medical-treatment-with-tamsulosin-a-prospective-open-label-pilot-study
#18
S Masciovecchio, A B Di Pasquale, G Ranieri, G Romano, L Di Clemente
OBJECTIVE: Lower urinary tract symptoms (LUTS) are frequently experienced in association with benign prostatic enlargement (BPE). Current guidelines state that alpha-blockers should be considered the first-line therapy of LUTS associated with BPE in most patients. However, in clinical practice treatment efficacy differs among individuals and, therefore, intra-class switch from one alpha-blocker to another, is frequently applied. In particular, switching to silodosin in clinical practice appears an intriguing therapeutic strategy due to the peculiar pharmacological properties of this molecule...
November 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29162085/association-of-lower-urinary-tract-symptoms-and-oab-severity-with-quality-of-life-and-mental-health-in-china-taiwan-and-south-korea-results-from-a-cross-sectional-population-based-study
#19
Kyu-Sung Lee, Tag Keun Yoo, Limin Liao, Jianye Wang, Yao-Chi Chuang, Shih-Ping Liu, Romeo Chu, Budiwan Sumarsono
BACKGROUND: Lower urinary tract symptoms (LUTS) and overactive bladder (OAB) symptoms have a substantial effect on quality of life (QoL). We report QoL and mental health results from a LUTS prevalence study in three Asian countries. METHODS: A cross-sectional, population-representative, internet-based study among individuals aged ≥40 years in China, Taiwan and South Korea. Instruments included: Overactive Bladder Symptom Score (OABSS); International Prostate Symptom Score (IPSS); other International Continence Society (ICS) symptom questions; health-related QoL 12-item short-form (HRQoL-SF12v2); Work Limitations Questionnaire (WLQ); Hospital Anxiety and Depression Scale (HADS)...
November 21, 2017: BMC Urology
https://www.readbyqxmd.com/read/29161773/silodosin-for-the-treatment-of-lower-urinary-tract-symptoms-in-men-with-benign-prostatic-hyperplasia
#20
REVIEW
Jae Hung Jung, Jiye Kim, Roderick MacDonald, Balaji Reddy, Myung Ha Kim, Philipp Dahm
BACKGROUND: A variety of alpha-blockers are used for treating lower urinary tract symptoms (LUTS) in men with benign prostatic hyperplasia (BPH). Silodosin is a novel, more selective alpha-blocker, which is specific to the lower urinary tract and may have fewer side effects than other alpha-blockers. OBJECTIVES: To assess the effects of silodosin for the treatment of LUTS in men with BPH. SEARCH METHODS: We performed a comprehensive search using multiple databases (Cochrane Library, MEDLINE, EMBASE, Scopus, Google Scholar, and Web of Science), trials registries, other sources of grey literature, and conference proceedings with no restrictions on the language of publication or publication status up until 13 June 2017...
November 22, 2017: Cochrane Database of Systematic Reviews
keyword
keyword
27915
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"