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https://www.readbyqxmd.com/read/28525945/the-protective-effect-of-luteolin-on-myocardial-ischemia-reperfusion-i-r-injury-through-tlr4-nf-%C3%AE%C2%BAb-nlrp3-inflammasome-pathway
#1
Xu Zhang, Qianming Du, Yan Yang, Jianing Wang, Shuai Dou, Chao Liu, Junguo Duan
The purpose of the present study was to investigate the effect of Luteolin(Lut) on myocardial ischemia reperfusion injury and explore the underlying mechanism. Myocardial ischemia reperfusion injury (I/R) model was induced with 30min of left anterior descending (LAD) occlusion followed by 24h of reperfusion. In vivo, the rats were randomly divided into 5 groups: (1)Sham, (2)I/R, (3)I/R+Lut(40mg/kg), (4)I/R+Lut(80mg/kg) and (5)I/R+Lut(160mg/kg). In vitro, the H9c2 cells were assigned to five groups: (1)control, (2)hypoxia-reoxygenation(H/R), (3)H/R+Lut(5μM), (4)H/R+Lut(10μM) and (5)H/R+Lut(20μM)...
May 15, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28516315/-finding-the-needle-in-a-haystack-oncologic-evaluation-of-patients-treated-for-luts-with-holmium-laser-enucleation-of-the-prostate-holep-versus-transurethral-resection-of-the-prostate-turp
#2
Annika Herlemann, Kerstin Wegner, Alexander Roosen, Alexander Buchner, Philipp Weinhold, Alexander Bachmann, Christian G Stief, Christian Gratzke, Giuseppe Magistro
PURPOSE: To evaluate oncologic parameters of men with bothersome LUTS undergoing surgical treatment with HoLEP or TURP. METHODS: Five hundred and eighteen patients undergoing HoLEP (n = 289) or TURP (n = 229) were retrospectively analyzed for total PSA, prostate volume, PSA density, history of prostate biopsy, resected prostate weight, and histopathological features. Univariate and multivariate logistic regression models were used to identify independent predictors of incidental PCa (iPCa)...
May 17, 2017: World Journal of Urology
https://www.readbyqxmd.com/read/28508459/tailoring-pharmacotherapy-for-male-lower-urinary-tract-symptoms-a-prospective-multicenter-observational-trial
#3
Hyun Hwan Sung, Kwang Jin Ko, Yoon Seok Suh, Joon Chul Kim, Jong Bo Choi, Yun-Seob Song, Kyu-Sung Lee
OBJECTIVES: The aim of this study was to evaluate the pattern of tailoring and efficacy of several types of pharmacotherapy in male LUTS. METHODS: Prospectively 404 male subjects were included who were over 40 years old, had at least 3 months symptom duration, and 12 or higher international prostate symptom score (IPSS). Subjects were treated with several types of pharmacotherapy for 6 months and were evaluated with IPSS/QoL at every follow-up. Subjects were subdivided into storage (44%), nocturia (18...
May 2017: International Journal of Clinical Practice
https://www.readbyqxmd.com/read/28508455/a-multicenter-real-life-study-of-the-efficacy-of-an-alpha-blocker-with-or-without-anticholinergic-agent-imidafenacin-treatment-in-patients-with-lower-urinary-tract-symptoms-benign-prostatic-hyperplasia-and-storage-symptoms
#4
Seok Cho, Soon-Sun Kwon, Kwang Woo Lee, Tag Keun Yoo, Dong Gil Shin, Soo Woong Kim, Jae Hyun Bae, Hoon Choi, Young Ho Kim
AIMS: To evaluate the efficacy and safety of combination therapy comprising a short-acting anticholinergic, imidafenacin and an alpha-blocker compared with monotherapy with an alpha-blocker only in men with lower urinary tract symptoms (LUTS) and storage symptoms. METHODS: The 12-week, prospective, double-blind, randomised trial enrolled men with LUTS and storage symptom. The inclusion criteria were a total International Prostate Symptom Score (IPSS) ≥12, an IPSS question 4 score ≥2, ≥8 micturitions in 24 hours, and a prostate volume >20 mL...
May 2017: International Journal of Clinical Practice
https://www.readbyqxmd.com/read/28507683/supramolecular-assembly-of-platinum-containing-polyhedral-oligomeric-silsesquioxanes-an-interplay-of-intermolecular-interactions-and-a-correlation-between-structural-modifications-and-morphological-transformations
#5
Ho-Leung Au-Yeung, Anthony Yiu-Yan Tam, Sammual Yu-Lut Leung, Vivian Wing-Wah Yam
A series of alkynylplatinum(ii) terpyridine complexes functionalized with polyhedral oligomeric silsesquioxane (POSS) moieties has been demonstrated to exhibit drastic color changes and give various distinctive nanostructures with interesting multi-stage morphological transformations from spheres to nanoplates in response to solvent conditions through the interplay of various intermolecular interactions, including hydrophilic-hydrophilic, hydrophobic-hydrophobic, Pt···Pt and π-π stacking interactions. These supramolecular architectures can be systematically modified and controlled through the molecular design and the variation of solvent compositions...
March 1, 2017: Chemical Science
https://www.readbyqxmd.com/read/28506862/a-relevant-mid-term-12-months-placebo-effect-on-lower-urinary-tract-symptoms-and-maximum-flow-rate-in-male-luts-bph-a-meta-analysis
#6
Klaus Eredics, Stephan Madersbacher, Ingrid Schauer
OBJECTIVE: To assess the mid- to long-term placebo effect of medical and instrumental management of male lower urinary tract symptoms (LUTS). This is - generally - a long-term treatment strategy. Therefore, knowledge on the mid- to long-term placebo effect is of considerable interest. The paucity of data on this topic prompted us to investigate this issue in a meta-analysis. METHODS: All randomized controlled trials (RCTs) with the indication BPH/LUTS containing a placebo- or sham treatment arm and with a follow-up of 12 months were eligible...
May 12, 2017: Urology
https://www.readbyqxmd.com/read/28499730/effects-of-withdrawing-alpha-1-blocker-from-the-combination-therapy-with-alpha-1-blocker-and-5-alpha-reductase-inhibitor-in-patients-with-lower-urinary-tract-symptoms-suggestive-of-benign-prostatic-hyperplasia-a-prospective-and-comparative-trial-using-urodynamics
#7
Yoshihisa Matsukawa, Shun Takai, Yasuhito Funahashi, Tsuyoshi Majima, Masashi Kato, Tokunori Yamamoto, Momokazu Gotoh
PURPOSE: To compare the effects on lower urinary tract symptoms (LUTS) and bladder outlet obstruction between combination therapy with α1 blocker and 5α-reductase inhibitor and a switch to 5α-reductase inhibitor monotherapy, and determine the factors influencing changes in LUTS after α1 blocker withdrawal. MATERIALS AND METHODS: One-hundred and forty outpatients with LUTS suggestive of benign prostatic hyperplasia received combination therapy with silodosin 8 mg/day and dutasteride 0...
May 9, 2017: Journal of Urology
https://www.readbyqxmd.com/read/28497089/impact-of-oral-capsule-of-peganum-harmala-on-alleviating-urinary-symptoms-in-men-with-benign-prostatic-hyperplasia-a-randomized-clinical-trial
#8
Majid Shirani-Boroujeni, Saeed Heidari-Soureshjani, Zahra Keivani Hafshejani
Introduction: Benign prostatic hyperplasia (BPH) is considered as a major cause of lower urinary tract symptoms (LUTS) in older men and its most common sign is nocturia. Objectives: This study aimed to determine the effect of the seeds of Peganum harmala compared with tamsulosin on alleviating urinary symptoms in patients with BPH. Patients and Methods: In this single blind clinical trial study, 90 patients diagnosed with BPH and LUTS, based on international prostate standard survey (IPSS) were divided into three groups...
2017: Journal of Renal Injury Prevention
https://www.readbyqxmd.com/read/28495071/perioperative-and-economic-analysis-of-surgical-treatments-for-benign-prostatic-hyperplasia-a-study-of-the-french-committee-on-lut
#9
R Mathieu, S Lebdai, J N Cornu, A Benchikh, A R Azzouzi, N B Delongchamps, O Dumonceau, A Faix, M Fourmarier, O Haillot, B Lukacs, V Misrai, A de La Taille, G Robert, A Descazeaud
PURPOSE: To evaluate perioperative cost related to surgical treatments of benign prostatic obstruction (BPO): photoselective vaporization of the prostate (pvp), holmium/thullium laser enucleation (HoLEP/ThuLEP), transurethral resection of the prostate (TURP) and open prostatectomy (OP). MATERIAL AND METHODS: We retrospectively collected data from 237 patients who consecutively underwent a surgical treatment for BPH between January 2012 and June 2013 at nine institutions in France...
May 8, 2017: Progrès en Urologie
https://www.readbyqxmd.com/read/28493523/fibrillar-collagen-genes-are-not-co-ordinately-up-regulated-with-tgf-%C3%AE-1-expression-in-finasteride-treated-prostate
#10
Flávia Karina Delella, Fernanda Losi Alves de Almeida, Helga Caputo Nunes, Jaqueline Carvalho Rinaldi, Sérgio Luis Felisbino
Benign prostatic hyperplasia (BPH) is the most common cause of lower urinary tract symptoms (LUTS) in older men. In this regard, recent studies have attempted to define the relationships between prostatic fibrosis, LUTS, and increased expression of transforming growth factor β1 (TGF β1) in BHP. Therapeutic approaches for BPH such as 5-α-reductase inhibitors and alpha-adrenergic blocking agents increase TGF β1 expression in the prostatic tissue. Here, we investigated the effects of the 5-α-reductase inhibitor-finasteride-on rat ventral prostate tissue, especially with regard to the tissue distribution and gene expression of fibrillar collagens...
May 11, 2017: Cell Biology International
https://www.readbyqxmd.com/read/28483466/role-of-body-mass-index-in-school-aged-children-with-lower-urinary-tract-dysfunction-does-weight-classification-predict-treatment-outcome
#11
Angela M Arlen, Christopher S Cooper, Traci Leong
INTRODUCTION: Lower urinary tract (LUT) dysfunction comprises a large percentage of pediatric urology referrals. Childhood obesity is a major health concern, and has been associated with voiding symptoms. We assessed the impact of body mass index (BMI) on treatment outcomes of children presenting with LUT or bladder-bowel dysfunction (BBD). STUDY DESIGN: Children aged 5-17 years diagnosed with non-neurogenic LUT dysfunction and no prior urologic diagnoses were identified...
April 25, 2017: Journal of Pediatric Urology
https://www.readbyqxmd.com/read/28479770/vitamin-d-deficiency-and-lower-urinary-tract-symptoms-in-males-above-50-years-of-age
#12
Mohamed Abdemonem Elshazly, Mohamed Farag Sultan, Hamdy Abdelmawla Aboutaleb, Shady Mohamed Salem, Mohamed Sayedahmed Aziz, Tarek Mohamed Abd Elbaky, Eid Abdelrasoul Elsherif, Maher Mohamed Gawish, Feras Tarek Alajrawi, Fahd Abdulla Algady Elgadi, Awad Husein Thaher, Mohamed Ahmed Shebl, Adel Mohamed Allam, Elija Kehinde
CONTEXT: Lower urinary tract symptoms (LUTSs) in elderly males are usually related to benign prostatic hyperplasia (BPH) in the majority of cases. It is estimated that BPH affects half of men above the age of 50 years. Recently, a relationship between Vitamin D deficiency and LUTS in elderly males has been reported. AIMS: The aim of this study was to analyze Vitamin D levels in males aged above 50 years presenting with LUTS. SETTINGS AND DESIGN: This is a prospective case-control study...
April 2017: Urology Annals
https://www.readbyqxmd.com/read/28479236/evidence-for-the-impact-of-diet-fluid-intake-caffeine-alcohol-and-tobacco-on-lower-urinary-tract-symptoms-a-systematic-review
#13
REVIEW
Catherine S Bradley, Bradley A Erickson, Emily E Messersmith, Anne P Cameron, H Henry Lai, Karl J Kreder, Claire C Yang, Robert M Merion, Tamara G Bavendam, Ziya Kirkali
PURPOSE: Foods, fluid intake, caffeine, alcohol, and tobacco may influence lower urinary tract symptoms (LUTS). Changes in these potentially modifiable non-urologic factors (NUF) are often suggested to improve LUTS. To better understand the relationship of NUFs with LUTS, we performed a systematic literature review to examine, grade, and summarize reported associations between LUTS and diet, fluid intake, caffeine, tobacco and alcohol use. MATERIALS AND METHODS: We performed PubMed searches for eligible articles providing evidence on associations between one or more NUF and LUTS...
May 4, 2017: Journal of Urology
https://www.readbyqxmd.com/read/28478699/management-of-lower-urinary-tract-symptoms-in-parkinson-s-disease-in-the-neurology-clinic
#14
Arina Madan, Sudeshna Ray, Daniel Burdick, Pinky Agarwal
This clinical review aims to evaluate lower urinary tract symptoms (LUTS) in Parkinson's disease (PD) patients and the current treatment options available for these symptoms in a neurology setting. The review also addresses when referral to urology is appropriate. A literature search was conducted using the keywords `LUTS`, `non-motor symptoms', `overactive bladder`, `Parkinson's disease` and `urinary symptoms` using the Medline/Pubmed search engine. Data collected ranged from 2000 to present with emphasis on recent publications...
May 7, 2017: International Journal of Neuroscience
https://www.readbyqxmd.com/read/28474611/patient-reported-ejaculatory-function-and-satisfaction-in-men-with-lower-urinary-tract-symptoms-benign-prostatic-hyperplasia
#15
Min Chul Cho, Jung Kwon Kim, Sang Hoon Song, Sung Yong Cho, Sang Wook Lee, Soo Woong Kim, Jae-Seung Paick
This study aimed to investigate perceived ejaculatory function/satisfaction before treatment for lower urinary tract symptoms (LUTS)/benign prostatic hyperplasia (BPH) and to identify associations between specific categories of ejaculatory dysfunctions (EjDs) and LUTS. A total of 1574 treatment-naïve men with LUTS/BPH were included in this study. All patients underwent routine evaluation for LUTS/BPH including the International Index of Erectile Function and a 5-item questionnaire developed to assess ejaculatory volume/force/pain/satisfaction/latency time...
May 2, 2017: Asian Journal of Andrology
https://www.readbyqxmd.com/read/28471525/the-association-between-lower-urinary-tract-symptoms-and-falls-forming-a-theoretical-model-for-a-research-agenda
#16
William Gibson, Kathleen F Hunter, Richard Camicioli, Joanne Booth, Dawn A Skelton, Chantale Dumoulin, Lorna Paul, Adrian Wagg
BACKGROUND: There is a well-recognised association between falls and lower urinary tract symptoms (LUTS) in older adults, with estimates of odd ratios for falls in the presence of LUTS ranging between 1.5 and 2.3. Falls and LUTS are both highly prevalent among older people and both are markers of frailty, with significant associated morbidity, mortality, and healthcare resource cost. This association is not well examined or explained in the literature. AIMS: We aimed to outline current knowledge of the association between falls and lower urinary tract symptoms and suggest a research program to further investigate this...
May 4, 2017: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/28464366/healthcare-resource-utilization-and-cost-among-males-with-lower-urinary-tract-symptoms-with-a-predominant-storage-component-in-spain-the-epidemiological-cross-sectional-mercury-study
#17
Carlos Errando-Smet, Carlos Müller-Arteaga, Marta Hernández, Enrique Lenero, Montse Roset
AIMS: To assess the relationship between storage-predominant LUTS and healthcare resource consumption and cost among males in Spain. METHODS: In this non-interventional, cross-sectional study, urologists enrolled males with storage-predominant LUTS and recorded the consumption of healthcare resources (medical visits, diagnostic tests/monitoring, treatment, and hospitalizations) within the previous 6 months. The cost of healthcare resources was calculated from unit costs extracted from a Spanish eHealth database...
May 2, 2017: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/28464331/does-deep-brain-stimulation-improve-lower-urinary-tract-symptoms-in-parkinson-s-disease
#18
Lambertus P Witte, Vincent J J Odekerken, Judith A Boel, P Richard Schuurman, Lara C Gerbrandy-Schreuders, Rob M A de Bie
AIMS: To investigate whether deep brain stimulation (DBS) of the globus pallidus pars interna (GPi) or the subthalamic nucleus (STN) improve lower urinary tract symptoms (LUTS) in advanced Parkinson's disease (PD). METHODS: An exploratory post-hoc analysis was performed of specific LUTS items of questionnaires used in a randomized clinical trial with 128 patients (NSTAPS study). First, we compared scores on LUTS items at baseline and 12 months for the GPi DBS and STN DBS group separately...
May 2, 2017: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/28462172/aggressive-angiomyxoma-involving-penis-and-urethra-a-case-report
#19
Shivashankar Damodaran, Devakannan Gengan, Sashi T Walling
Aggressive angiomyxoma is a rare benign mesenchymal stromal tumour, characterized by locally infiltrative nature and a tendency for recurrence. Only a few cases of penile involvement have been reported in the literature so far. We report a case of aggressive penile angiomyxoma in a sixty-two-year-old obese, diabetic male patient. He presented with obstructive lower urinary tract symptoms (LUTS) and diffuse enlargement of the penis and scrotum. He was managed with excision, reduction scrotoplasty, internal urethrotomy, followed by Leuprolide therapy for prevention of recurrence...
July 2017: Urology Case Reports
https://www.readbyqxmd.com/read/28461987/fatigue-depression-and-quality-of-life-in-patients-with-prostatic-diseases
#20
Tobias Engl, Daniela Drescher, Ralf Bickeböller, Ralph Grabhorn
INTRODUCTION: Fatigue and depression are commonly attributed to malignant and chronic benign diseases. However, these phenomena have been little investigated to date in prostatic diseases. Our aim was to compare fatigue and depression in prostate cancer patients treated with Androgen Deprivation Therapy (ADT) and in patients with Lower Urinary Tract Symptoms (LUTS) / Benign Prostatic Syndrome. MATERIAL AND METHODS: 100 patients each with PCa (prostate cancer) and BPS (Benign Prostatic Syndrome) were surveyed using the Brief Fatigue Inventory (BFI), EORTC-QLQ C30 [1], and Beck Depression Inventory (BDI)...
2017: Central European Journal of Urology
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