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Matthew W Beal
Lower urinary tract (LUT) emergencies are common reasons for small animal patients to be presented to their veterinarians. Patient stabilization and management of life threatening problems is a priority in this population. Urethral obstruction is a common LUT emergency. Urethral stent placement has gained popularity over the past decade allowing for a minimally invasive, image-guided method for relief of urethral obstruction in some patient populations. This article focuses on candidate selection, diagnostic workup, stent placement technique, and the expected outcome and complications for patients undergoing urethral stent placement and addresses some additional strategies for interventional management of LUT emergencies...
June 19, 2018: Veterinary Clinics of North America. Small Animal Practice
Ruiqi Baiyun, Siyu Li, Biying Liu, Jingjing Lu, Yueying Lv, Jianwen Xu, Jiahui Wu, Jiayi Li, Zhanjun Lv, Zhigang Zhang
Inorganic mercury is a toxic metal of worldwide concern, and causes serious cardiac injury. However, effective treatment for cardiac injury induced by mercuric chloride (HgCl2 ) has not been fully identified. Luteolin (Lut) is a novel natural antioxidant. This study aimed to investigate the role of Lut on HgCl2 -induced cardiac injury. Male Wistar rats were randomly assigned to 4 groups, control, Lut (80 mg/kg intragastrically), HgCl2 (80 mg/L, in drinking water), and HgCl2 + Lut groups. The results indicated that Lut significantly ameliorated cardiac histopathological damage, oxidative stress, and apoptosis induced by HgCl2 in the rat heart...
June 19, 2018: Ecotoxicology and Environmental Safety
Claus G Roehrborn, Martin M Miner, Richard Sadovsky
In this review, we focus on current trends in the management of male lower urinary tract symptoms (LUTS), defined here as LUTS, namely, storage, voiding, and post-micturition symptoms presumed secondary to benign prostatic hyperplasia (BPH), and discuss possible novel approaches toward better care. According to results of a PubMed database search covering the last 10 years and using keywords pertaining to male LUTS, this condition continues to be globally undiagnosed or diagnosed late, partly because of men's hesitation to seek help for perceived embarrassing problems or problems considered a normal part of aging...
June 22, 2018: Postgraduate Medicine
Muhammad Salman, Amer Hayat Khan, Syed Azhar Syed Sulaiman, Jeffery Hughes, Junaid Habib Khan, Khalid Hussain
OBJECTIVE: The objective of the current study was to develop an Urdu version of the International Prostate Symptom Score (IPSS-U) and validate it for Pakistani patients suffering from lower urinary tract symptoms (LUTS). MATERIAL AND METHODS: IPSS-U was developed by a two-step forward and back translation and to evaluate its psychometric properties, a prospective study involving patients suffering from LUTS (n=267) was conducted at Outpatient Urology Department, Mayo Hospital, Lahore, Pakistan...
July 2018: Turkish Journal of Urology
Joao Pimentel Torres, Nuno Morais, Agostinho Cordeiro, Estevao Lima
Lower urinary tract symptoms (LUTS) are a common complaint in the general population with great impact on the quality of life. Besides the classical pathologies, there are less common causes that must be considered in the treatment approach for patients with LUTS. We present the case of a 30-year-old patient with multiple emergency department episodes with dysuria, urinary frequency, suprapubic pain and an episode of acute urinary retention. The blood and urine tests only revealed increased systemic inflammatory parameters...
June 21, 2018: BMJ Case Reports
Lorna Booth, Dawn A Skelton, Suzanne Hagen, Joanne Booth
AIMS: To identify age and gender stratified normative values for the International Prostate Symptom Score (IPSS) for older community-living adults. METHODS: Secondary analysis of data from a large cohort study produced norms presented as means, standard deviations, medians, ranges, and percentile scores. Non-parametric analyses were conducted to investigate the effect that demographic variables, smoking status and comorbidity had on the severity of Lower Urinary Tract Symptoms (LUTS) as measured by the IPSS...
June 21, 2018: Neurourology and Urodynamics
Josephina A N Meester, Maja Sukalo, Kim C Schröder, Denny Schanze, Gareth Baynam, Guntram Borck, Nuria C Bramswig, Duygu Duman, Brigitte Gilbert-Dussardier, Muriel Holder-Espinasse, Peter Itin, Diana S Johnson, Shelagh Joss, Hannele Koillinen, Fiona McKenzie, Jenny Morton, Heike Nelle, Willie Reardon, Claudia Roll, Mustafa A Salih, Ravi Savarirayan, Ingrid Scurr, Miranda Splitt, Elizabeth Thompson, Hannah Titheradge, Colm P Travers, Lionel Van Maldergem, Margo Whiteford, Dagmar Wieczorek, Geert Vandeweyer, Richard Trembath, Lut Van Laer, Bart L Loeys, Martin Zenker, Laura Southgate, Wim Wuyts
Adams-Oliver syndrome (AOS) is a rare developmental disorder, characterized by scalp aplasia cutis congenita (ACC) and transverse terminal limb defects (TTLD). Autosomal dominant forms of AOS are linked to mutations in ARHGAP31, DLL4, NOTCH1 or RBPJ, while DOCK6 and EOGT underlie autosomal recessive inheritance. Data on the frequency and distribution of mutations in large cohorts is currently limited. The purpose of this study was therefore to comprehensively examine the genetic architecture of AOS in an extensive cohort...
June 20, 2018: Human Mutation
Lei Wang, Tongqing Wang, Jian Liu, Jizheng Wang
Background: We aimed to investigate the prevalence of erectile dysfunction (ED) in patients with lower urinary tract symptoms (LUTS) and to explore the correlation of ED with LUTS and its clinical features. Methods: Overall, 400 outpatients and inpatients with LUTS diagnosed in Zhengzhou Central Hospital, Zhengzhou University, Zhengzhou, Henan Province, China from June 2015 to June 2017 were collected. LUTS degree was assessed by the International Prostate Symptom Score (IPSS), and ED degree was assessed by the International Index of Erectile Function (IIEF-5)...
May 2018: Iranian Journal of Public Health
Ebru Dundar Yenilmez, Lut Tamam, Onur Karaytug, Abdullah Tuli
BACKGROUND: The interindividual genetic variations in drug metabolizing enzymes effects the impact and toxicity in plenty of drugs. OBJECTIVE: The CYP1A2, CYP2C9, CYP2C19 and CYP2D6 gene polymorphisms characterized using high resolution melting analysis (HRMA) in follow-up patients in psychiatry clinic as a preliminary preparation for personalized medicine. METHOD: Genotyping of CYP1A2*1F, CYP2C9 *2, *3, CYP2C19 *2, *3 and *17 and CYP2D6 *3, *4 was conducted in 101 patients using HRMA...
June 19, 2018: Combinatorial Chemistry & High Throughput Screening
Kariyappa Vijay, Poorigali Raghavendra-Rao Sowmya, Bangalore Prabhashankar Arathi, Shivaprasad Shilpa, Hulikere Jagdish Shwetha, Marisiddaiah Raju, Vallikannan Baskaran, Rangaswamy Lakshminarayana
The combination of carotenoids and doxorubicin (DOX) selectively alters oxidative stress-mediated apoptosis in breast cancer cells. Primarily, cytotoxic efficiency of carotenoids (β-carotene, BC; lutein, LUT; astaxanthin, AST; or fucoxanthin, FUCO) either with or without a minimal cytotoxic dose of DOX was evaluated in MCF-7 (0.12 μM) and MDA-MB-231 cells (0.28 μM). The higher cell growth inhibition of BC and/or LUT with DOX was selected for testing in further cell-based assays. Low-dose DOX significantly enhanced cytotoxicity in carotenoid (<5 μM)-treated cells compared to high-dose DOX (>1 μM) or carotenoid (20 μM) treatment alone...
June 18, 2018: Food and Chemical Toxicology
Juntaro Koyama, Yasuhiro Kaiho, Yoshihide Kawasaki, Tomonori Sato, Taro Fukushi, Atsushi Kyan, Yoichi Arai
OBJECTIVES: The phosphodiesterase type 5 inhibitor tadalafil is one of the first-choice drugs for benign prostate hyperplasia (BPH) patients with lower urinary tract symptoms (LUTS). However, tadalafil is not always equally beneficial to every patient. In order to determine whether penile blood pressure (PBP) can be used to identify patients who can benefit from tadalafil treatment, the correlation between PBP at baseline and changes in LUTS induced by tadalafil treatment was studied prospectively...
June 19, 2018: BJU International
Francisco Maciá Pérez, Leandro Zambrano Méndez, José Vicente Berná Martínez, Roberto Sepúlveda Lima
This article presents the design of a field programmable gate array (FPGA)-based prototype of a system on chip (SoC) capable of behaving as one of the nerve centres comprising the neuroregulatory system in humans: the cortical-diencephalic nerve centre. The neuroregulatory system is a complex nerve system consisting of a heterogeneous group of nerve centres. These centres are distributed throughout the length of the spinal cord, are autonomous, communicate via interneurons, and govern and regulate the behaviour of multiple organs and systems in the human body...
June 13, 2018: Computers in Biology and Medicine
H Aydogmus, U S Demirdal
OBJECTIVE: The association of vitamin D deficiency and pelvic floor dysfunction has been examined by numerous studies. Lower urinary tract symptoms (LUTS) associated with bladder filling and voiding functions are common in both sexes. A recent study reports a higher incidence of LTUS in men over 50 years old with vitamin D deficiency. The aim of the study is to investigate whether there is a difference in the Lower Urinary Tract Symptoms frequency between women with vitamin D deficiency and the control group or not...
June 9, 2018: European Journal of Obstetrics, Gynecology, and Reproductive Biology
Lauren P Wallner, Julia R DiBello, Bonnie H Li, Stephen K Van Den Eeden, Sheila Weinmann, Debra P Ritzwoller, Jill E Abell, Ralph D'Agostino, Ronald K Loo, David S Aaronson, Ralph I Horwitz, Steven J Jacobsen
OBJECTIVE: To compare the risk of mortality among men treated for benign prostatic hyperplasia (BPH) with 5?-reductase inhibitors (5ARI) to those treated with alpha-blockers (AB) in community practice settings. METHODS: We employed a retrospective matched cohort study in 4 regions of an integrated healthcare system. Men ages 50 years and older who initiated pharmaceutical treatment for BPH/LUTS between 1992 and 2008 and had at least 3 consecutive prescriptions were eligible and followed through 2010 (N=174,895)...
June 12, 2018: Urology
Matic Ivančič, Peter Naglič, Franjo Pernuš, Boštjan Likar, Miran Bürmen
Subdiffusive reflectance captured at short source-detector separations provides increased sensitivity to the scattering phase function and hence allows superficial probing of the tissue ultrastructure. Consequently, estimation of subdiffusive optical parameters has been the subject of many recent studies focusing on lookup-table-based (LUT) inverse models. Since an adequate description of the subdiffusive reflectance requires additional scattering phase function related optical parameters, the LUT inverse models, which grow exponentially with the number of estimated parameters, become excessively large and computationally inefficient...
June 15, 2018: Optics Letters
P V Glybochko, Yu G Alyaev, L M Rapoport, D V Enikeev, Z Okhunov, C Netsch, L G Spivak, M S Taratkin
Endoscopic enucleation of the prostate (EEP) techniques such as HoLEP (holmium laser enucleation of the prostate), ThuLEP (thulium laser enucleation of the prostate) and electroenucleation (mono- or bipolar) are highly effective and safe. They have been endorsed by the latest version of the European Association of Urology guidelines as an alternative to not only open adenomectomy but also transurethral resection of the prostate (EAU Guidelines on Treatment of Non-neurogenic Male LUTS 2018). Therefore, many urologists face the possibility of replacing the treatments of BPH...
May 2018: Urologii︠a︡
R E Amdii, A S Al' Shukri
This literature review focuses on the use of Serenoa repens extracts in the treatment of benign prostatic hyperplasia (BPH) and lower urinary tract symptoms (LUTS). Extracts of Serenoa repens produce marked anti-inflammatory, anti-androgenic and antiproliferative effects. Various extracts differ in their activity depending on the concentration of free fatty acids and the method of extract preparation. Extracts of Serenoa Repens from different manufacturers vary considerably in composition, effectiveness and supporting evidence...
May 2018: Urologii︠a︡
O B Loran, A A Seregin
AIM: To investigate changes in the IPSS after a six-month treatment with Omnic Ocas and its effect on the quality of life of patients in routine urological practice in the Russian Federation in a prospective, multicenter, observational study. PATIENTS AND METHODS: The study comprised 7000 patients with a verified diagnosis of lower urinary tract symptoms/benign prostatic hyperplasia who received Omnic Ocas (tamsulosin) administered by 700 urologists in various Russian medical institutions...
May 2018: Urologii︠a︡
Jonathan J Aning, Kenneth R MacKenzie, Michael Fabricius, Elaine McColl, Mark I Johnson, Zafer Tandogdu, Naeem A Soomro, Christopher Harding
OBJECTIVE: To prospectively evaluate short- to medium-term patient-reported lower urinary tract symptoms (LUTS) and their effect on health-related quality of life (HRQoL) using validated questionnaires in a large cohort of patients following robotic-assisted radical prostatectomy (RARP) for prostate cancer. MATERIALS AND METHODS: HRQoL and LUTS outcomes were prospectively assessed in 357 consecutive men undergoing RARP at a single center from 2012 to 2015 using the functional assessment of cancer therapy-prostate (FACT-P) and the international consultation on incontinence modular questionnaire-male LUTS (ICIQ-MLUTS)...
June 9, 2018: Urologic Oncology
Michael Ho-Yeung Chan, Sammual Yu-Lut Leung, Vivian Wing-Wah Yam
The systematic control over association mechanisms of self-assembled materials has been demonstrated through the rational design and synthesis of a series of amphiphilic dinuclear alkynylplatinum(II) bzimpy (bzimpy = 2,6-bis( N-alkylbenzimidazol-2'-yl)pyridine) complexes containing the shape-persistent oligo( p-phenyleneethynylene)s. Multistage morphological transformations from plates to fibers and to spherical nanostructures under different solvent compositions have been demonstrated. The subtle balances between multiple noncovalent interactions including Pt···Pt, hydrophobic, hydrophilic, and π-π stacking interactions are found to have profound impact on the supramolecular assembly of the system, in which a change in the association mechanism from isodesmic to cooperative and back to isodesmic growth has been observed upon increasing hydrophilicity of the complexes...
June 11, 2018: Journal of the American Chemical Society
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