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CT perfusion, CCTA, CTA, CT FFR,

Jorge A Gonzalez, Michael J Lipinski, Lucia Flors, Peter W Shaw, Christopher M Kramer, Michael Salerno
We sought to compare the diagnostic performance of coronary computed tomography angiography (CCTA), computed tomography perfusion (CTP), and computed tomography (CT)-fractional flow reserve (FFR) for assessing the functional significance of coronary stenosis as defined by invasive FFR in patients with known or suspected coronary artery disease (CAD). CCTA has proved clinically useful for excluding obstructive CAD because of its high sensitivity and negative predictive value (NPV); however, the ability of CTA to identify functionally significant CAD has remained challenging...
November 1, 2015: American Journal of Cardiology
Yingwei Liu, Benjamin J W Chow, Girish Dwivedi
Coronary computed tomography angiography (CCTA) is an emerging modality for comprehensive non-invasive assessment of coronary artery disease (CAD). CCTA was traditionally used for anatomical assessment of coronary plaque, including luminal narrowing, plaque burden, location, and composition. Preliminary studies have also demonstrated CCTA's capabilities for functional assessment of coronary plaque, including fractional flow reserve (FFR) and myocardial perfusion-albeit they are not routinely available at all centers and are focus of research...
February 2015: Cardiovascular Diagnosis and Therapy
Quynh A Truong, Paul Knaapen, Gianluca Pontone, Daniele Andreini, Jonathon Leipsic, Patricia Carrascosa, Bin Lu, Kelley Branch, Subha Raman, Stephen Bloom, James K Min
BACKGROUND: Dual-energy CT (DECT) has potential to improve myocardial perfusion for physiologic assessment of coronary artery disease (CAD). Diagnostic performance of rest-stress DECT perfusion (DECTP) is unknown. OBJECTIVE: DECIDE-Gold is a prospective multicenter study to evaluate the accuracy of DECT to detect hemodynamic (HD) significant CAD, as compared to fractional flow reserve (FFR) as a reference standard. METHODS: Eligible participants are subjects with symptoms of CAD referred for invasive coronary angiography (ICA)...
October 2015: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
R Dörr, C T Kadalie, W G Franke, M Gutberlet
Clinical studies have consistently shown that there is only a very weak correlation between the angiographically determined severity of coronary artery disease (CAD) and disturbance of regional coronary perfusion. On the other hand, the results of randomized trials with a fractional flow reserve (FFR)-guided coronary intervention (DEFER, FAME I, FAME II) showed that it is not the angiographically determined morphological severity of coronary artery disease but the functional severity determined by FFR that is critical for prognosis and the indications for revascularization...
June 2013: Herz
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