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https://www.readbyqxmd.com/read/29390572/acute-liver-failure-caused-by-pembrolizumab-in-a-patient-with-pulmonary-metastatic-liver-cancer-a-case-report
#1
Zhenping Wu, Lingling Lai, Ming Li, Lunli Zhang, Wenfeng Zhang
RATIONALE: Keytruda (pembrolizumab) is an inhibitor of programmed cell death receptor-1 (PD-1), which was approved to treat advanced melanoma and nonsmall cell lung cancer patients who do not respond to other treatment. However, its efficacy and security in the treatment of advanced liver cancer is still under investigation. PATIENT CONCERNS: A 60-year-old man was diagnosed with pulmonary metastatic liver cancer who accepted pembrolizumab treatment after the failure of sorafenib...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29329933/combined-hepatic-and-pulmonary-metastasectomies-from-colorectal-carcinoma-data-from-the-prospective-spanish-registry-2008-2010
#2
Jose R Jarabo, Ana M Gómez, Joaquín Calatayud, Carlos A Fraile, Elena Fernández, Nuria Pajuelo, Raul Embún, Laureano Molins, Juan J Rivas, Florentino Hernando
INTRODUCTION: Resection of both liver and lung metastases from colorectal carcinoma (CRC) is a standard of care in selected patients with oligometastatic disease. We present here the analysis of the subgroup of patients undergoing combined surgery from the Spanish Group of Surgery of Pulmonary Metastases (PM) from Colorectal Carcinoma (GECMP-CCR-SEPAR). METHODS: We analyze characteristics, survival and prognostic factors of patients undergoing combined resection from March-2008 to February-2010 and followed-up during at least 3 years, from the prospective multicenter Spanish Registry...
April 2018: Archivos de Bronconeumología
https://www.readbyqxmd.com/read/29288609/resection-of-concomitant-hepatic-and-extrahepatic-metastases-from-colorectal-cancer-a-worthwhile-operation
#3
COMPARATIVE STUDY
Andrei Diaconescu, Sorin Alexandrescu, Zenaida Ionel, Cristian Zlate, Razvan Grigorie, Vladislav Brasoveanu, Doina Hrehoret, Silviu Ciurea, Florin Botea, Dana Tomescu, Gabriela Droc, Adina Croitoru, Vlad Herlea, Mirela Boros, Mugur Grasu, Radu Dumitru, Mihai Toma, Mihnea Ionescu, Catalin Vasilescu, Irinel Popescu
Background: The benefit of hepatic resection in case of concomitant colorectal hepatic and extrahepatic metastases (CHEHMs) is still debatable. The purpose of this study is to assess the results of resection of hepatic and extrahepatic metastases in patients with CHEHMs in a high-volume center for both hepatobiliary and colorectal surgery and to identify prognostic factors that correlate with longer survival in these patients. METHOD: It was performed a retrospective analysis of 678 consecutive patients with liver resection for colorectal cancer metastases operated in a single Centre between April 1996 and March 2016...
November 2017: Chirurgia
https://www.readbyqxmd.com/read/29135843/abscessing-infection-by-streptococcus-mitis-mimicking-metastatic-lesions-in-a-5-year-old-girl-with-nephroblastoma-a-case-report
#4
Lara Imhof, Simone Schrading, Till Braunschweig, Gerhard Steinau, Jan Wilhelm Spillner, Alexander Puzik, Lisa Lassay, Udo Kontny
Streptococcus mitis is a common pathogen causing infections in oncological patients. However, cases of abscesses caused by Streptococcus mitis in oncological patients have not been reported so far. We report on 5-year-old child with nephroblastoma and pulmonary and hepatic metastases at diagnosis who went into complete remission undergoing chemotherapy and nephrectomy, and who developed new round lesions in liver and lungs under continuous chemotherapy suggestive of new metastases. Biopsy of the lesions revealed abscesses with detection of Streptococcus mitis...
November 13, 2017: Journal of Pediatric Hematology/oncology
https://www.readbyqxmd.com/read/29037039/synthesis-and-preclinical-evaluation-of-18-f-peg3-fpn-for-the-detection-of-metastatic-pigmented-melanoma
#5
Xiaodong Xu, Lujie Yuan, Lianglan Yin, Yaqun Jiang, Yongkang Gai, Qingyao Liu, Yichun Wang, Yongxue Zhang, Xiaoli Lan
Although (18)F-5-fluoro-N-(2-[diethylamino]ethyl)picolinamide ((18)F-5-FPN) is considered a promising radiopharmaceutical for PET imaging of melanoma, it accumulates at high concentrations in the liver. The aim in this research was to optimize the structure of (18)F-5-FPN with triethylene glycol to reduce liver uptake as well as improve pharmacokinetics, and to evaluate its performance in detection of melanoma liver and lung metastases. (18)F-PEG3-FPN was successfully prepared with a high radiolabeling yield (44...
November 6, 2017: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/28966242/the-role-of-e-cadherin-%C3%AE-catenin-in-hydroxysafflor-yellow-a-inhibiting-adhesion-invasion-migration-and-lung-metastasis-of-hepatoma-cells
#6
Long Ma, Li Liu, Yicong Ma, Hua Xie, Xue Yu, Xu Wang, Angran Fan, Dongyu Ge, Yingying Xu, Qian Zhang, Cai Song
Liver cancer is the second leading cause of cancer death. Due to treatments failures from drug resistance and cancer metastasis, discovering more effective treatments is imperative. As an angiogenesis inhibitor extracted from the Chinese herb-Safflower, hydroxysafflor yellow A (HSYA) inhibits the tumor growth in H22-bearing mice. Poorly differentiated hepatoma cells showed the ability to invade and metastasize, which are dependent on the angiogenesis. Accordingly, we hypothesized that HSYA could inhibit the metastasis of liver cancer cells...
2017: Biological & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/28948336/repeated-resections-of-hepatic-and-pulmonary-metastases-from-colorectal-cancer-provide-long-term-survival
#7
Jocelyn Bellier, Julien De Wolf, Mohamed Hebbar, Mehdi El Amrani, Christophe Desauw, Emmanuelle Leteurtre, François-René Pruvot, Henri Porte, Stéphanie Truant
BACKGROUND: Liver and lungs are the two most frequent sites of metastatic spread of colorectal cancer (CRC). Complete resection of liver and/or lung metastases is the only chance of cure, and several studies have reported an improved survival after an aggressive treatment. Nevertheless, CRC liver metastases (CLM) have been recognized as a pejorative factor for patients undergoing pulmonary metastasectomy. We report our experience with patients successively operated on for CRC hepatic and pulmonary metastasis (CPM) and seek to identify prognostic factors...
September 25, 2017: World Journal of Surgery
https://www.readbyqxmd.com/read/28709876/is-cure-possible-after-sequential-resection-of-hepatic-and-pulmonary-metastases-from-colorectal-cancer
#8
Muthukumarassamy Rajakannu, Pierre Magdeleinat, Eric Vibert, Oriana Ciacio, Gabriella Pittau, Pasquale Innominato, Antonio SaCunha, Daniel Cherqui, Jean-François Morère, Denis Castaing, René Adam
BACKGROUND: Surgical resection is an established therapeutic strategy for colorectal cancer (CRC) metastasis. However, controversies exist when CRC liver and lung metastases (CLLMs) are found concomitantly or when recurrence develops after either liver or lung resection. No predictive score model is available to risk stratify these patients in preparation for surgery, and cure has not yet been reported. PATIENTS AND METHODS: All consecutive patients who had undergone surgery for CLLMs at our institution during a 20-year period were reviewed...
June 23, 2017: Clinical Colorectal Cancer
https://www.readbyqxmd.com/read/28678578/accuracy-of-whole-body-dwi-for-metastases-screening-in-a-diverse-group-of-malignancies-comparison-with-conventional-cross-sectional-imaging-and-nuclear-scintigraphy
#9
COMPARATIVE STUDY
Samir Mustaffa Paruthikunnan, Rajagopal Kadavigere, Lakshmikanth Halegubbi Karegowda
OBJECTIVE: The purpose of this study is to assess the role of whole-body (WB) DWI as a screening modality for the detection of metastases and to compare it to conventional cross-sectional imaging modalities or nuclear scintigraphy in a population with various histopathologic malignancies. SUBJECTS AND METHODS: WB DWI and conventional imaging (CT, MRI, or scintigraphy) were performed for patients with known malignancies for metastatic workup, and these patients were followed up for a period of 1 year...
September 2017: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/28467174/nodular-typhlocolitis-heterakiasis-and-mesenchymal-neoplasia-in-a-ring-necked-pheasant-phasianus-colchicus-with-immunohistochemical-characterization-of-visceral-metastases
#10
Lauren Himmel, Rachel Cianciolo
A 9-y-old, male ring-necked pheasant ( Phasianus colchicus) was autopsied following euthanasia because of acute distress, recumbency, and dyspnea. The bird had experienced a protracted period of neuromuscular disease localized to the left sciatic nerve. Gross and histologic examination of the large intestine revealed intramural nodules predominantly comprised of atypical, whorling spindle cells with small cores of granulomatous inflammation centered on cross-sections of immature adult nematodes. The body structures of these metazoan organisms and clinical disease manifestation are consistent with Heterakis isolonche infection...
July 2017: Journal of Veterinary Diagnostic Investigation
https://www.readbyqxmd.com/read/28402263/post-pulmonary-metastasectomy-prognosis-after-curative-resection-for-colorectal-cancer
#11
Jee Yeon Kim, In Ja Park, Hyeong Ryul Kim, Dong Kwan Kim, Jong Lyul Lee, Yong Sik Yoon, Chan Wook Kim, Seok-Byung Lim, Jung Bok Lee, Chang Sik Yu, Jin Cheon Kim
PURPOSE: We aimed to compare disease-free survival after pulmonary metastasectomy to that after hepatic metastasectomy, and to identify prognostic factors after pulmonary metastasectomy. RESULTS: Between 2005 and 2015, 129 patients underwent resection of isolated metachronous lung metastases from colorectal cancer. Three-year DFS after pulmonary metastasectomy was similar to that after hepatic metastasectomy (50.7% vs. 45.5%, respectively; p=0.58). Rectal cancer (hazard ratio [HR]: 2...
May 30, 2017: Oncotarget
https://www.readbyqxmd.com/read/28363484/radiobiological-parameters-of-liver-and-lung-metastases-derived-from-tumor-control-data-of-3719-metastases
#12
Rainer J Klement
BACKGROUND AND PURPOSE: The radiobiological parameters for liver and lung metastases treated with stereotactic body radiation therapy (SBRT) are poorly defined. This project aimed at estimating these parameters from published tumor control probability (TCP) data, and separately for metastases with colorectal cancer (CRC) and non-CRC histology. MATERIALS AND METHODS: A total of 62 studies with 89 different treatment prescriptions for a total of 3719 metastases were analyzed in a Bayesian framework using four different radiobiological models: The LQ, mLQ, LQ-L and the regrowth model which accounts for tumor regrowth after SBRT...
May 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/28258454/indeterminate-pulmonary-nodules-in-resected-liver-metastases-from-colorectal-cancer-a-comparison-of-patient-outcomes
#13
COMPARATIVE STUDY
V Robertson, C P Neal, M Jones, A R Dennison, G Garcea
AIMS: Hepatic metastasectomy remains the only potentially curative treatment for colorectal liver metastases (CRLM). Some of these patients develop indeterminate pulmonary nodules (IPNs). This study aimed to compare outcomes of patients with and without IPN undergoing resection of CRLM to ascertain whether their presence is clinically significant. METHODS: Cases and controls were identified from a prospectively maintained database of CRLM resections. Patients with staging radiology demonstrating IPNs were included as cases...
July 2017: World Journal of Surgery
https://www.readbyqxmd.com/read/28203555/surgical-resection-of-synchronous-and-metachronous-lung-and-liver-metastases-of-colorectal-cancers
#14
Shinseok Jeong, Jin Seok Heo, Jin Young Park, Dong Wook Choi, Seong Ho Choi
PURPOSE: Surgical resection of isolated hepatic or pulmonary metastases of colorectal cancer is an established procedure, with a 5-year survival rate of about 50%. However, the role of surgical resections in patients with both hepatic and pulmonary metastases is not well established. We aimed to analyze overall survival of these patients and associated factors. METHODS: Data retrospectively collected from 66 patients who underwent both hepatic and pulmonary metastasectomy after colorectal cancer surgery from August 2002 through August 2013 were analyzed...
February 2017: Annals of Surgical Treatment and Research
https://www.readbyqxmd.com/read/27928604/-surgery-of-colorectal-lung-metastases-results-of-a-survey-in-germany
#15
W Dudek, W Schreiner, P Stapel, N Vassos, R Grützmann, H Sirbu
BACKGROUND: There is no evidence from randomized trials on the prognostic significance of pulmonary metastasectomy of colorectal cancer. The objective of this study was to assess the current criteria for indications, preoperative diagnostics and preferred operative techniques of pulmonary metastasectomy in Germany. METHODS: An anonymous survey was carried out in 239 German centers performing thoracic surgery in October 2015. RESULTS: Chest computed tomography (CT, 98%), liver CT (62%), pelvis CT (39%) and fluorodeoxyglucose positron emission tomography (FDG-PET, 37%) were used by the respondents (65% of participants) for preoperative staging...
June 2017: Der Chirurg; Zeitschrift Für Alle Gebiete der Operativen Medizen
https://www.readbyqxmd.com/read/27529888/uptake-difference-by-somatostatin-receptors-in-a-patient-with-neuroendocrine-tumor-99mtc-octreotide-uptake-in-the-lung-without-uptake-in-liver-lesions
#16
Elahe Pirayesh, Mahasti Amoui, Majid Assadi
The diagnostic value of somatostatin receptor scintigraphy (SRS) in detecting tumors has been assessed in a number of studies. We present a 30-year-old female with a history of eight months cough and left shoulder pain. Radiologic evaluation showed pulmonary mass and hepatic lesions, which were pathologically diagnosed as neuroendocrine carcinoma. 99mTc-octreotide scan demonstrated that the pulmonary lesion was positive for somatostatin receptor (SSTR), while the liver metastases were SSTR negative. The present case highlights the significance of a differential uptake pattern by somatostatin receptors in SRS in patients with neuroendocrine tumors...
October 5, 2015: Molecular Imaging and Radionuclide Therapy
https://www.readbyqxmd.com/read/27473725/prognostic-factors-after-pulmonary-metastasectomy-of-colorectal-cancers-influence-of-liver-metastasis
#17
Seok Kim, Hong Kwan Kim, Jong Ho Cho, Yong Soo Choi, Kwhanmien Kim, Jhingook Kim, Jae Ill Zo, Young Mog Shim, Jin Seok Heo, Woo Yong Lee, Hee Cheol Kim
BACKGROUND: Our objective was to evaluate the influence of liver metastasis on survival after pulmonary metastasectomy in patients with colorectal cancer (CRC). METHODS: We retrospectively reviewed a total of 524 patients and were classified into two groups based on the presence of liver metastasis. Group HM + PM (n = 106) included patients who previously received a hepatic metastasectomy and then received pulmonary metastasectomy. Group PM (n = 418) included patients who only received pulmonary metastasectomy with no liver metastasis...
July 29, 2016: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/27113798/plasma-ceramide-a-real-time-predictive-marker-of-pulmonary-and-hepatic-metastases-response-to-stereotactic-body-radiation-therapy-combined-with-irinotecan
#18
Nolwenn Dubois, Emmanuel Rio, Natacha Ripoche, Véronique Ferchaud-Roucher, Marie-Hélène Gaugler, Loic Campion, Michel Krempf, Christian Carrie, Marc Mahé, Xavier Mirabel, François Paris
BACKGROUND AND PURPOSES: Early biomarkers of tumour response are needed to discriminate between responders and non-responders to radiotherapy. We evaluated the ability of ceramide, a bioactive sphingolipid, to predict tumour sensitivity in patients treated by hypofractionated stereotactic body radiation therapy (SBRT) combined with irinotecan chemotherapy. MATERIALS AND METHODS: Plasma levels of total ceramide and of its subspecies were measured before and during treatment in 35 patients with liver and lung oligometastases of colorectal cancer included in a phase II trial...
2016: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/26866882/a-rare-case-of-lacrimal-adenoid-cystic-carcinoma-with-large-hepatic-and-multiple-pulmonary-metastases-with-successful-surgical-treatment
#19
Priyanka Akhilesh Sali, Kamal Sunder Yadav, Kirti Bushan, Virendra Rajpurohit, Paresh Pramod Varty, Sanjay Sharma
INTRODUCTION: Adenoid cystic carcinoma (ACC) of the lacrimal gland is rare but with high recurrence rates and late metastases. They occasionally metastasise via haematogenous spread to lungs, brain and bone. Liver is a rare site of metastasis and is usually present with disseminated disease. PRESENTATION OF CASE: A 42 year old lady, a known case of adenoid cystic carcinoma of the lacrimal gland who had been operated 4 years ago for the same followed by chemotherapy and radiotherapy...
2016: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/26712481/the-benefit-of-abdominal-sonography-and-chest-x-ray-for-staging-oral-squamous-cell-carcinomas-in-stages-uicc-i-and-ii
#20
Clarissa Precht, Sara Baustian, Silke Tribius, Maximilian Schöllchen, Henning Hanken, Ralf Smeets, Max Heiland, Alexander Gröbe
PURPOSE: The purpose of this study was to evaluate how often distant metastases occur in localized oral squamous cell carcinomas (OSCC). The investigators hypothesize that abdominal sonography and chest X-ray may not be necessary for initial staging of early oral squamous cell carcinoma in UICC stage I/II. MATERIAL AND METHODS: The investigators implemented a retrospective study. The study collective was composed of 124 patients with OSCC, who were treated in the department of oral and maxillofacial surgery during the years 2011-2015 at the University Medical Center Hamburg Eppendorf, Germany...
February 2016: Journal of Cranio-maxillo-facial Surgery
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