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https://www.readbyqxmd.com/read/28724047/correlation-between-virulence-markers-of-helicobacter-pylori-in-the-oral-cavity-and-gastric-biopsies
#1
Myriam Lucrecia Medina, Marcelo Gabriel Medina, Luis Antonio Merino
BACKGROUND: The clinical outcome of Helicobacter pylori infection has been associated with virulence factors. The presence of these factors is useful as molecular markers in the identification of the high risk for developing severe gastric pathologies. OBJECTIVE: To correlate the presence of virulence markers cagA and bab2A of H. pylori in oral and gastric biopsy samples. METHODS: An observational, prospective, descriptive, and cross-sectional study was carried out between September 2011 and September 2012...
July 13, 2017: Arquivos de Gastroenterologia
https://www.readbyqxmd.com/read/28723278/a-case-of-cannabinoid-hyperemesis-syndrome-with-heliobacter-pylori-and-pre-eclampsia-during-pregnancy
#2
Madeline Manning Meurer, Kalyan Chakrala, Dinesh Gowda, Charles Burns, Randall Kelly, Natalia Schlabritz-Loutsevitch
The condition termed cannabinoid hyperemesis syndrome (CHS) was characterized a decade ago by Allen et al. and includes cyclic episodes of nausea and vomiting and the learned behavior of hot bathing in individuals with chronic cannabis abuse. During pregnancy, the differential diagnosis of this syndrome is challenging since it can be masked by typical symptoms of early pregnancy or by hyperemesis gravidarum, a complication of early pregnancy associated with excessive nausea and vomiting. We herein describe the case of a 21-year-old primigravida patient diagnosed with hyperemesis gravidarum at 6 weeks of gestation and with pre-eclampsia at 35 weeks...
July 19, 2017: Substance Abuse
https://www.readbyqxmd.com/read/28720314/antibiotic-susceptibility-of-helicobacter-pylori-strains-isolated-from-iranian-children-high-frequency-of-a2143g-point-mutation-associated-with-clarithromycin-resistance
#3
Shima Mahmoudi, Setareh Mamishi, Maryam Banar, Sepideh Keshavarz Valian, Abbas Bahador, Mehri Najafi, Fatemeh Farahmand, Babak Pourakbari
OBJECTIVE: Increasing antibiotic resistance in Helicobacter pylori is a global concern and is associated with treatment failure. The aim of this study was to evaluate antibiotic resistance of H. pylori to different antibiotics including amoxicillin, erythromycin, ciprofloxacin, furazolidone, tetracycline, metronidazole and clarithromycin and to detection of A2143G mutation in clarithromycin resistant isolates by real-time PCR technique. METHODS: Ninety patients with upper gastrointestinal symptoms were enrolled in this study...
July 15, 2017: Journal of Global Antimicrobial Resistance
https://www.readbyqxmd.com/read/28720300/epidemiological-study-of-gastric-helicobacter-spp-in-dogs-with-gastrointestinal-disease-in-japan-and-diversity-of-helicobacter-heilmannii-sensu-stricto
#4
Sanae Kubota-Aizawa, Koichi Ohno, Kenjiro Fukushima, Hideyuki Kanemoto, Ko Nakashima, Kazuyuki Uchida, James K Chambers, Yuko Goto-Koshino, Takayasu Watanabe, Tsutomu Sekizaki, Hitomi Mimuro, Hajime Tsujimoto
Epidemiological and pathological studies of Helicobacter spp. in canine stomachs in Japan were performed to investigate strain specific pathogenicity. Gastric biopsies from 144 dogs with gastrointestinal diseases were evaluated for the presence of Helicobacter spp. using genus and species specific PCRs for Helicobacter felis, Helicobacter bizzozeronii, Helicobacter heilmannii sensu stricto (s.s.) and Helicobacter pylori. PCR indicated that 50/144 (34.7%) dogs were infected with Helicobacter spp. Of the genus positive samples, 21/50 could not be amplified by any of the species specific PCRs...
July 2017: Veterinary Journal
https://www.readbyqxmd.com/read/28719592/ten-day-quadruple-therapy-comprising-proton-pump-inhibitor-bismuth-tetracycline-and-levofloxacin-is-more-effective-than-standard-levofloxacin-triple-therapy-in-the-second-line-treatment-of-helicobacter-pylori-infection-a-randomized-controlled-trial
#5
Ping-I Hsu, Feng-Woei Tsai, Sung-Shuo Kao, Wen-Hung Hsu, Jin-Shiung Cheng, Nan-Jing Peng, Kuo-Wang Tsai, Huang-Ming Hu, Yao-Kuang Wang, Seng-Kee Chuah, Angela Chen, Deng-Chyang Wu
OBJECTIVES: Proton pump inhibitor (PPI)-amoxicillin-fluoroquinolone triple therapy is recommended as a second-line treatment of Helicobacter pylori infection in the Maastricht V/Florence Consensus Report. However, the eradication rate of this standard salvage treatment is suboptimal. The objective of this study is to compare the efficacy of esomeprazole-bismuth-tetracycline-levofloxacin therapy (TL quadruple therapy) and esomeprazole-amoxicillin-levofloxacin triple therapy (AL triple therapy) in rescue treatment for H...
July 18, 2017: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/28719375/compounded-levofloxacin-triple-therapy-is-safe-and-effective-for-refractory-helicobacter-pylori
#6
Xian-Jun Mah, Vikas Gupta, Srey Neth Loch, Golo Ahlenstiel, David van de Poorten
Failure of first line and subsequent Helicobacter pylori therapy is a significant problem, as alternate treatments are cumbersome and difficult to access. The purpose of this study was to evaluate the efficacy and safety of a compounded levofloxacin triple therapy in clinical practice as a second or third-line salvage regimen for Helicobacter pylori. Patients referred after first or subsequent treatment failures were prescribed compounded levofloxacin 500 mg, amoxicillin 1 g, and esomeprazole 40 mg, all twice daily for 10 days...
July 2017: International Journal of Pharmaceutical Compounding
https://www.readbyqxmd.com/read/28718212/effectiveness-of-helicobacter-pylori-eradication-in-pregnant-women-with-idiopathic-thrombocytopenic-purpura
#7
Yosuke Ono, Arihiro Shiozaki, Noriko Yoneda, Satoshi Yoneda, Osamu Yoshino, Shigeru Saito
Platelet counts increase after eradication of Helicobacter pylori (Hp) infection in non-pregnant patients with Hp-associated idiopathic thrombocytopenic purpura (ITP); however, improvement in pregnant patients has not yet been reported. We treated four pregnant women for Hp-positive ITP after Hp eradication. In three of four cases, platelet counts increased to levels exceeding 10 × 10(9) /L two weeks after eradication, and these levels were maintained until delivery. Vaginal deliveries were uncomplicated, and no excessive blood loss occurred in any of the cases...
July 2017: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/28717848/new-identification-of-three-or-more-campylobacter-species-on-the-basis-of-a-degenerate-pcr-rflp-method-targeting-gyrb-gene
#8
Hiroyuki Fukuda, Fumiko Kojima, Shuji Fujimoto
This method was aimed targeting more Campylobacter species than conventional PCR-based identifications. They generally use species-specific primers focusing on clinically common species like C. jejuni, resulting in failure to recognize other species. We made the PCR-based identification more flexible using degenerate primers and DdeI- and MboI-separately used RFLP assay, which were designed on the basis of gyrB nucleotide sequence data of 14 Campylobacter species including C. jejuni, C. coli, and C. fetus. Ninety-four clinical isolates from patients with Campylobacter gastroenteritis and 13 biochemically identified C...
July 17, 2017: Current Microbiology
https://www.readbyqxmd.com/read/28717077/gastric-hyperplastic-polyps-associated-with-proton-pump-inhibitor-use-in-a-case-without-a-history-of-helicobacter-pylori-infection
#9
Shuichi Miyamoto, Mototsugu Kato, Kana Matsuda, Satoshi Abiko, Momoko Tsuda, Takeshi Mizushima, Keiko Yamamoto, Shoko Ono, Takahiko Kudo, Yuichi Shimizu, Kanako C Hatanaka, Izumi Tsunematsu, Naoya Sakamoto
A 56-year-old man with gastroesophageal reflux disease (GERD) was referred to our hospital. Esophagogastroduodenoscopy (EGD) revealed no evidence of any polypoid lesions in the stomach, and the patient had no history of Helicobacter pylori infection. He received omeprazole (20 mg) once daily for the GERD. EGD was performed at 1 year after the start of omeprazole administration, and this time, gastric hyperplastic polyps (GHPs) were detected. The GHPs increased in size as the omeprazole treatment continued, but they markedly decreased in size following omeprazole discontinuation...
2017: Internal Medicine
https://www.readbyqxmd.com/read/28715499/helicobacter-pylori-modulates-host-cell-responses-by-cagt4ss-dependent-translocation-of-an-intermediate-metabolite-of-lps-inner-core-heptose-biosynthesis
#10
Saskia C Stein, Eugenia Faber, Simon H Bats, Tatiana Murillo, Yvonne Speidel, Nina Coombs, Christine Josenhans
Highly virulent Helicobacter pylori cause proinflammatory signaling inducing the transcriptional activation and secretion of cytokines such as IL-8 in epithelial cells. Responsible in part for this signaling is the cag pathogenicity island (cagPAI) that codetermines the risk for pathological sequelae of an H. pylori infection such as gastric cancer. The Cag type IV secretion system (CagT4SS), encoded on the cagPAI, can translocate various molecules into cells, the effector protein CagA, peptidoglycan metabolites and DNA...
July 17, 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/28713773/the-cytolethal-distending-toxin-subunit-cdtb-of-helicobacter-hepaticus-promotes-senescence-and-endoreplication-in-xenograft-mouse-models-of-hepatic-and-intestinal-cell-lines
#11
Christelle Péré-Védrenne, Martina Prochazkova-Carlotti, Benoit Rousseau, Wencan He, Lucie Chambonnier, Elodie Sifré, Alice Buissonnière, Pierre Dubus, Francis Mégraud, Christine Varon, Armelle Ménard
Cytolethal distending toxins (CDTs) are common among pathogenic bacteria of the human and animal microbiota. CDTs exert cytopathic effets, via their active CdtB subunit. No clear description of those cytopathic effects has been reported at the cellular level in the target organs in vivo. In the present study, xenograft mouse models of colon and liver cell lines were set up to study the effects of the CdtB subunit of Helicobacter hepaticus. Conditional transgenic cell lines were established, validated in vitro and then engrafted into immunodeficient mice...
2017: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/28713064/novel-risk-stratification-for-metachronous-recurrence-after-curative-endoscopic-submucosal-dissection-for-early-gastric-cancer
#12
Hyo-Joon Yang, Sang Gyun Kim, Joo Hyun Lim, Ji Min Choi, Sooyeon Oh, Jae Yong Park, Seung Jun Han, Jung Kim, Hyunsoo Chung, Hyun Chae Jung
BACKGROUND AND AIMS: This study stratified the risk of developing metachronous gastric cancer (MGC) after curative endoscopic submucosal dissection (ESD) of early gastric cancer (EGC) to enable the customization of endoscopic surveillance for MGC. METHODS: A total of 1115 patients who underwent curative ESD based on the expanded criteria for differentiated EGC from 2005 to 2014 at a single tertiary hospital were enrolled in this retrospective cohort study. They were followed up with annual endoscopy for a median of 50...
July 13, 2017: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/28711545/antiulcer-properties-of-fruits-and-vegetables-a-mechanism-based-perspective
#13
REVIEW
Choudhary Harsha, Kishore Banik, Devivasha Bordoloi, Ajaikumar B Kunnumakkara
Gastric ulcer is the damage caused to mucosal layer of the stomach under the action of various factors like high levels of acid and pepsin, invasion by Helicobacter pylori, etc. Although most cases have been controlled and the rate of ulcer occurrence has reduced over the last few decades, gastric ulcer still holds a prime concern today. A range of palliative medicines comprising proton pump inhibitors, H2 receptor antagonists, COX-2 inhibitors (coxibs) is widely in use and patients have also been administered with acid suppression therapies...
July 12, 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/28710240/a-rare-case-of-gastric-mixed-adenoneuroendocrine-carcinoma-manec-with-gastric-helicobacter-pylori-negative-mucosa-associated-lymphoid-tissue-malt-lymphoma
#14
Babikir Kheiri, Mohammed Osman, Douglas Congdon, Ghassan Bachuwa
No abstract text is available yet for this article.
July 14, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28707344/detection-of-viable-helicobacter-pylori-inside-free-living-amoebae-in-wastewater-and-drinking-water-samples-from-eastern-spain
#15
Laura Moreno-Mesonero, Yolanda Moreno, José Luis Alonso, M Antonia Ferrús
Helicobacter pylori is one of the most concerning emerging waterborne pathogens. It has been suggested that it could survive in water inside free-living amoebae (FLA), but nobody has studied this relationship in the environment yet. Thus, we aimed to detect viable H. pylori cells from inside FLA in water samples. Sixty-nine wastewater and 31 drinking water samples were collected. FLA were purified and identified by PCR and sequencing. For exclusively detecting H. pylori inside FLA, samples were exposed to sodium hypochlorite and assayed by specific PMA-qPCR, DVC-FISH and culture...
July 14, 2017: Environmental Microbiology
https://www.readbyqxmd.com/read/28707297/functional-gastrointestinal-disorders-in-children-from-low-socio-economic-status-and-helicobacter-pylori-infection
#16
F Jaime, A Villagrán, C Hernández, M Ortiz, C Serrano, P R Harris
BACKGROUND: Most studies on functional gastrointestinal disorders (FGIDs) in children are based on data from the northern hemisphere. Scientific reports are arising in South American population, but little is still known about children from low socio-economic status (SES), where Helicobacter pylori infection is endemic. Our objective was to evaluate the prevalence of FGIDs in school children from low SES and its relationship with H. pylori infection. METHODS: Children from 3 public schools of low SES from Santiago de Chile were included...
July 14, 2017: Child: Care, Health and Development
https://www.readbyqxmd.com/read/28706428/appropriateness-of-the-study-of-iron-deficiency-anemia-prior-to-referral-for-small-bowel-evaluation-at-a-tertiary-center
#17
Jaime Pereira Rodrigues, Rolando Pinho, Joana Silva, Ana Ponte, Mafalda Sousa, João Carlos Silva, João Carvalho
AIM: To evaluate the adequacy of the study of iron deficiency anemia (IDA) in real life practice prior to referral to a gastroenterology department for small bowel evaluation. METHODS: All consecutive patients referred to a gastroenterology department for small bowel investigation due to iron deficiency anemia, between January 2013 and December 2015 were included. Both patients referred from general practitioners or directly from different hospital departments were selected...
June 28, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28706400/hybrid-therapy-versus-sequential-therapy-for-eradication-of-helicobacter-pylori-a-randomized-controlled-trial
#18
Sahoo Ashokkumar, Sonia Agrawal, Jharna Mandal, Sathasivam Sureshkumar, Gubbi Shamanna Sreenath, Vikram Kate
OBJECTIVE: To compare the sequential therapy (ST) with the hybrid therapy (HT) for the eradication of Helicobacter pylori. MATERIALS AND METHODS: Patients with peptic ulcer disease and gastritis found to be H. pylori positive were randomized to HT group who received omeprazole (20 mg bid) and amoxicillin (1 g bid) for 7 days followed by omeprazole (20 mg bid), amoxicillin (1 g bid), clarithromycin (500 mg bid), and metronidazole (400 mg tid) for the next 7 days and ST group who received omeprazole and amoxicillin for 5 days followed by omeprazole, clarithromycin, and metronidazole for the next 5 days...
April 2017: Journal of Pharmacology & Pharmacotherapeutics
https://www.readbyqxmd.com/read/28706140/positive-helicobacter-pylori-status-is-associated-with-better-overall-survival-for-gastric-cancer-patients-evidence-from-case-cohort-studies
#19
Xuqian Fang, Kun Liu, Jialin Cai, Fangxiu Luo, Fei Yuan, Peizhan Chen
Helicobacter pylori (H. pylori) infection increases the gastric cancer risk; however, the influences of H. pylori infection status on the outcomes for gastric cancer patients have not yet clearly defined. Herein, we systematically assessed the epidemiological studies regarding the associations between the H.pylori infection status at diagnosis and the prognosis for gastric cancer patients with the meta-analysis methods. Thirty-three eligibility studies with 8,199 participants that had determined the H.pylori infection status and the outcomes for gastric cancer patients were identified through searching the PubMed and MEDLINE databases updated to March 1st, 2017...
June 28, 2017: Oncotarget
https://www.readbyqxmd.com/read/28705420/is-it-necessary-to-perform-full-pathologic-review-of-all-gastric-remnants-following-sleeve-gastrectomy
#20
S K Hansen, B J Pottorf, H W Hollis, J L Rogers, F A Husain
BACKGROUND: This study attempts to determine if enough pathological abnormalities in gastric remnants from sleeve gastrectomy exist to warrant full pathologic evaluation in all remnants. METHODS: Data was collected on patients undergoing sleeve gastrectomy between 08/01/2011 and 06/30/2014. Significant abnormalities were classified as any pathology that might require follow-up or treatment beyond standard follow-up. Age, comorbidities, gender, and Helicobacter pylori titers were analyzed and compared with pathology specimens using 95% confidence intervals and Phi contingency coefficients...
July 1, 2017: American Journal of Surgery
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