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https://www.readbyqxmd.com/read/27933701/ccr2-mediates-helicobacter-pylori-induced-immune-tolerance-and-contributes-to-mucosal-homeostasis
#1
Xia Sun, Min Zhang, Mohamad El-Zaatari, Gray B Huffnagle, John Y Kao
BACKGROUND: We previously demonstrated that H. pylori infection leads to increased induction of regulatory T cells in local and systemic immune compartments. Here, we investigate the role of CCR2 in the tolerogenic programing of dendritic cells in a mouse model of H. pylori infection. MATERIALS AND METHODS: CCR2 deficient (CCR2KO) mice and wild-type (Wt) mice infected with H. pylori SS1 strain were analyzed by qPCR and FACS analysis. In vitro, bone marrow-derived DC on day 6 from CCR2KO and Wt mice cocultured with or without H...
December 8, 2016: Helicobacter
https://www.readbyqxmd.com/read/27931317/influence-of-rack-design-and-disease-prevalence-on-detection-of-rodent-pathogens-in-exhaust-debris-samples-from-individually-ventilated-caging-systems
#2
Beth A Bauer, Cynthia Besch-Williford, Robert S Livingston, Marcus J Crim, Lela K Riley, Matthew H Myles
Sampling of bedding debris within the exhaust systems of ventilated racks may be a mechanism for detecting murine pathogens in colony animals. This study examined the effectiveness of detecting pathogens by PCR analysis of exhaust debris samples collected from ventilated racks of 2 different rack designs, one with unfiltered air flow from within the cage to the air-exhaust pathway, and the other had a filter between the cage and the air-exhaust pathway. For 12 wk, racks were populated with either 1 or 5 cages of mice (3 mice per cage) infected with one of the following pathogens: mouse norovirus (MNV), mouse parvovirus (MPV), mouse hepatitis virus (MHV), Helicobacter spp...
November 2016: Journal of the American Association for Laboratory Animal Science: JAALAS
https://www.readbyqxmd.com/read/27931258/htra-mediated-e-cadherin-cleavage-is-limited-to-degp-and-degq-homologs-expressed-by-gram-negative-pathogens
#3
Carmen M Abfalter, Maria Schubert, Camilla Götz, Thomas P Schmidt, Gernot Posselt, Silja Wessler
BACKGROUND: The serine proteases HtrA/DegP secreted by the human gastrointestinal pathogens Helicobacter pylori (H. pylori) and Campylobacter jejuni (C. jejuni) cleave the mammalian cell adhesion protein E-cadherin to open intercellular adhesions. A wide range of bacteria also expresses the HtrA/DegP homologs DegQ and/or DegS, which significantly differ in structure and function. METHODS: E-cadherin shedding was investigated in infection experiments with the Gram-negative pathogens H...
December 8, 2016: Cell Communication and Signaling: CCS
https://www.readbyqxmd.com/read/27931194/serum-albumin-to-globulin-ratio-is-related-to-cognitive-decline-via-reflection-of-homeostasis-a-nested-case-control-study
#4
Teruhide Koyama, Nagato Kuriyama, Etsuko Ozaki, Daisuke Matsui, Isao Watanabe, Fumitaro Miyatani, Masaki Kondo, Aiko Tamura, Takashi Kasai, Yoichi Ohshima, Tomokatsu Yoshida, Takahiko Tokuda, Ikuko Mizuta, Shigeto Mizuno, Kei Yamada, Kazuo Takeda, Sanae Matsumoto, Masanori Nakagawa, Toshiki Mizuno, Yoshiyuki Watanabe
BACKGROUND: Recent research suggests that several pathogenetic factors, including aging, genetics, inflammation, dyslipidemia, diabetes, and infectious diseases, influence cognitive decline (CD) risk. However, no definitive candidate causes have been identified. The present study evaluated whether certain serum parameters predict CD. METHODS: A total of 151 participants were assessed for CD using the Mini-Mental State Examination (MMSE), and 34 participants were identified as showing CD...
December 8, 2016: BMC Neurology
https://www.readbyqxmd.com/read/27930533/association-of-vagus-nerve-severance-and-decreased-risk-of-subsequent-type-2-diabetes-in-peptic-ulcer-patients-an-asian-population-cohort-study
#5
Shih-Chi Wu, William Tzu-Liang Chen, Chu-Wen Fang, Chih-Hsin Muo, Fung-Chang Sung, Chung Y Hsu
Vagus nerve may play a role in serum glucose modulation. The complicated peptic ulcer patients (with perforation or/and bleeding) who received surgical procedures with or without vagotomy provided 2 patient populations for studying the impact of vagus nerve integrity. We assessed the risk of developing type 2 diabetes in peptic ulcer patients without and with complications by surgical treatment received in a retrospective population study using the National Health Insurance database in Taiwan.A cohort of 163,385 patients with peptic ulcer and without Helicobacter pylori infection in 2000 to 2003 was established...
December 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27930268/recombinant-bacillus-subtilis-spores-expressing-cholera-toxin-b-subunit-and-helicobacter-pylori-urease-b-confers-protection-against-h-pylori-in-mice
#6
Zhenwen Zhou, Hui Dong, Shuwen Yao, Yanmei Huang, Bingshao Liang, Yongqiang Xie, Yan Long, Jialiang Mai, Sitang Gong
Helicobacter pylori infection is associated with chronic gastritis, peptic ulcers, gastric cancer and mucosa-associated lymphoid tissue lymphoma. The limitations of current therapies for Helicobacter pylori infection include poor compliance and antibiotic resistance. Therefore, an effective anti-H. pylori vaccine would be an alternative or complement to antibiotic treatment. Urease B (UreB) is considered an ideal vaccine antigen against H. pylori infection. In this study, cholera toxin B subunit (CTB), a mucosal adjuvant, was used to enhance the immunogenicity of novel Bacillus subtilis spores vaccine that express CTB-UreB along with the B...
December 8, 2016: Journal of Medical Microbiology
https://www.readbyqxmd.com/read/27928455/effects-of-esomeprazole-on-the-healing-process-of-post-endoscopic-submucosal-dissection-gastric-ulcers-a-single-arm-prospective-trial
#7
Takashi Ichida, Fumihiko Kusano, Yoshinori Sakai
Objectives: Gastric endoscopic submucosal dissection (ESD) is currently a standard procedure. ESD enables en-bloc resection of large lesions, while inducing larger artificial ulcers to a greater extent than conventional procedures. Several studies have reported that proton pump inhibitors (PPIs) prevent delayed bleeding and expedite the artificial ulcer healing process. Esomeprazole, an S-isomer of omeprazole, is reportedly one of strongest inhibitors of gastric acid secretion. Previous studies have examined the effectiveness of esomeprazole...
2016: Journal of Rural Medicine: JRM
https://www.readbyqxmd.com/read/27923651/a-cheap-simple-high-throughput-method-for-screening-native-helicobacter-pylori-urease-inhibitors-using-a-recombinant-escherichia-coli-its-validation-and-demonstration-of-pistacia-atlantica-methanolic-extract-effectivity-and-specificity
#8
Natalie Amar, Avi Peretz, Yoram Gerchman
Helicobacter pylori is the most frequent and persistent bacterial infection worldwide, and a risk factor for active gastritis, peptic ulcers, mucosa-associated lymphoid tissue lymphoma, and gastric cancer. Although combined antibiotics treatment is effective cases of antibiotic resistance are reported at an alarming rate. The H. pylori urease enzyme is essential for the bacteria establishment in the gastric mucosa, resulting urease inhibitors being sought after as effective and specific anti- H. pylori treatment...
December 3, 2016: Journal of Microbiological Methods
https://www.readbyqxmd.com/read/27923069/characterization-in-helicobacter-pylori-of-a-nickel-transporter-essential-for-colonization-that-was-acquired-during-evolution-by-gastric-helicobacter-species
#9
Frédéric Fischer, Marie Robbe-Saule, Evelyne Turlin, Francesco Mancuso, Valérie Michel, Pierre Richaud, Frédéric J Veyrier, Hilde De Reuse, Daniel Vinella
Metal acquisition is crucial for all cells and for the virulence of many bacterial pathogens. In particular, nickel is a virulence determinant for the human gastric pathogen Helicobacter pylori as it is the cofactor of two enzymes essential for in vivo colonization, urease and a [NiFe] hydrogenase. To import nickel despite its scarcity in the human body, H. pylori requires efficient uptake mechanisms that are only partially defined. Indeed, alternative ways of nickel entry were predicted to exist in addition to the well-described NixA permease...
December 2016: PLoS Pathogens
https://www.readbyqxmd.com/read/27922485/effect-of-abdominal-visceral-fat-on-the-development-of-new-erosive-oesophagitis-a-prospective-cohort-study
#10
Su Youn Nam, Young-Woo Kim, Bum Joon Park, Kum Hei Ryu, Il Ju Choi, Byung-Ho Nam, Hyun Boem Kim
OBJECTIVES: Although abdominal visceral fat has been associated with erosive oesophagitis in cross-sectional studies, there are no data that describe its longitudinal effects. We aimed to evaluate the longitudinal effects of abdominal visceral fat on the development of new erosive oesophagitis in patients who did not have erosive oesophagitis at baseline. MATERIALS AND METHODS: This was a single-centre prospective study. A total of 1503 participants without erosive oesophagitis at baseline were followed up for 34 months and they underwent oesophagogastroduodenoscopy and computed tomography at both baseline and during follow-up...
December 2, 2016: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/27922429/multiplex-pcr-for-detection-of-helicobacter-pylori-infection-in-gastric-biopsies-with-lower-inflammatory-score
#11
Najmiyatul Fadilah, Alfizah Hanafiah, Hamizah Razlan, Zin Qin Wong, Isa Mohamed Rose, Md Mostafizur Rahman
BACKGROUND: No gold standard has yet been established for the diagnosis of H. pylori infection. A multiplex polymerase chain reaction (mPCR) was developed in this study for rapid, sensitive and specific detection of H. pylori from gastric biopsies. METHODS: H. pylori infections were determined by in-house rapid urease test (iRUT), culture, histology and multiplex PCR. RESULTS: A total of 140 (60.9%) from 230 patients were positive for H. pylori infection...
October 2016: British Journal of Biomedical Science
https://www.readbyqxmd.com/read/27922023/systematic-site-directed-mutagenesis-of-the-helicobacter-pylori-cagl-protein-of-the-cag-type-iv-secretion-system-identifies-novel-functional-domains
#12
Tobias Bönig, Patrick Olbermann, Simon H Bats, Wolfgang Fischer, Christine Josenhans
The Cag Type IV secretion system, which contributes to inflammation and cancerogenesis during chronic infection, is one of the major virulence factors of the bacterial gastric pathogen Helicobacter pylori. We have generated and characterized a series of non-marked site-directed chromosomal mutants in H. pylori to define domains of unknown function of the essential tip protein CagL of the Cag secretion system. Characterizing the CagL mutants, we determined that their function to activate cells and transport the effector CagA was reduced to different extents...
December 6, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27921009/adhesion-and-invasion-of-gastric-mucosa-epithelial-cells-by-helicobacter-pylori
#13
REVIEW
Ying Huang, Qi-Long Wang, Dan-Dan Cheng, Wen-Ting Xu, Nong-Hua Lu
Helicobacter pylori is the main pathogenic bacterium involved in chronic gastritis and peptic ulcer and a class 1 carcinogen in gastric cancer. Current research focuses on the pathogenicity of H. pylori and the mechanism by which it colonizes the gastric mucosa. An increasing number of in vivo and in vitro studies demonstrate that H. pylori can invade and proliferate in epithelial cells, suggesting that this process might play an important role in disease induction, immune escape and chronic infection. Therefore, to explore the process and mechanism of adhesion and invasion of gastric mucosa epithelial cells by H...
2016: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/27920769/transcriptional-profiling-of-type-ii-toxin-antitoxin-genes-of-helicobacter-pylori-under-different-environmental-conditions-identification-of-hp0967-hp0968-system
#14
María G Cárdenas-Mondragón, Miguel A Ares, Leonardo G Panunzi, Sabino Pacheco, Margarita Camorlinga-Ponce, Jorge A Girón, Javier Torres, Miguel A De la Cruz
Helicobacter pylori is a Gram-negative bacterium that colonizes the human gastric mucosa and is responsible for causing peptic ulcers and gastric carcinoma. The expression of virulence factors allows the persistence of H. pylori in the stomach, which results in a chronic, sometimes uncontrolled inflammatory response. Type II toxin-antitoxin (TA) systems have emerged as important virulence factors in many pathogenic bacteria. Three type II TA systems have previously been identified in the genome of H. pylori 26695: HP0315-HP0316, HP0892-HP0893, and HP0894-HP0895...
2016: Frontiers in Microbiology
https://www.readbyqxmd.com/read/27920199/the-active-bacterial-assemblages-of-the-upper-gi-tract-in-individuals-with-and-without-helicobacter-infection
#15
Christian Schulz, Kerstin Schütte, Nadine Koch, Ramiro Vilchez-Vargas, Melissa L Wos-Oxley, Andrew P A Oxley, Marius Vital, Peter Malfertheiner, Dietmar H Pieper
OBJECTIVE: Patients infected with Helicobacter pylori develop chronic gastritis with a subgroup progressing to further complications. The role of microbiota from the oral cavity swallowed with saliva and either transiting the stomach or persisting in the gastric mucosa is uncertain. It is also not known whether the bacterial community differs in luminal and mucosal niches. A key question is whether H. pylori influences the bacterial communities of gastroduodenal niches. DESIGN: Saliva, gastric and duodenal aspirates as well as gastric and duodenal biopsies were collected during oesophagogastroduodenoscopy from 24 patients (m:9, f:15, mean age 52...
December 5, 2016: Gut
https://www.readbyqxmd.com/read/27919744/co-infections-with-liver-fluke-and-helicobacter-species-a-paradigm-change-in-pathogenesis-of-opisthorchiasis-and-cholangiocarcinoma
#16
REVIEW
Banchob Sripa, Raksawan Deenonpoe, Paul J Brindley
Infection with the fish-borne liver fluke Opisthorchis viverrini is classified by the International Agency for Research on Cancer as a Group 1 carcinogen: definitely carcinogenic in humans. Cofactors likely contribute to bile duct cancer (cholangiocarcinoma) caused by this infection. Here we review recent findings that address the role of liver fluke associated H. pylori in hepatobiliary disease and malignancy. We hypothesize that co-infection by O. viverrini and the bacillus Helicobacter pylori is central of liver fluke infection associated cholangiocarcinoma...
December 2, 2016: Parasitology International
https://www.readbyqxmd.com/read/27919112/s2k-guideline-helicobacter-pylori-and-gastroduodenal-ulcer-disease
#17
(no author information available yet)
No abstract text is available yet for this article.
December 5, 2016: Zeitschrift Für Gastroenterologie
https://www.readbyqxmd.com/read/27917621/association-of-nucleotide-binding-oligomerization-domain-receptors-with-peptic-ulcer-and-gastric-cancer
#18
Rajeeh Mohammadian Amiri, Mohsen Tehrani, Shirin Taghizadeh, Javad Shokri-Shirvani, Hafez Fakheri, Abolghasem Ajami
Host innate immunity can affect the clinical outcomes of Helicobacter pylori infection, including gastritis, gastric ulcer, gastric adenocarcinoma, and MALT lymphoma. Nucleotide binding oligomerization domain (NOD)-1 and -2 are two molecules of innate immunity which are involved in the host defense against H. pylori. This study aimed to evaluate the effect of the expression level of NOD1 and NOD2 on the susceptibility to gastric cancer as well as peptic ulcer in individuals with H. pylori infection. The gene expression levels of these molecules were compared in three groups of non-ulcer dyspepsia (NUD) as a control group (n=52); peptic ulcer disease (PUD), (n=53); and gastric cancer (GC), (n=39)...
October 2016: Iranian Journal of Allergy, Asthma, and Immunology
https://www.readbyqxmd.com/read/27917200/sero-prevalence-and-associated-factors-of-helicobacter-pylori-infection-among-adult-patients-with-dyspepsia-attending-the-gastroenterology-unit-in-a-tertiary-hospital-in-mwanza-tanzania
#19
Hyasinta Jaka, Martha F Mushi, Mariam M Mirambo, Leonard Wilson, Jeremiah Seni, Majigo Mtebe, Stephen E Mshana
BACKGROUND: Prevalence of H.pylori infection varies greatly between populations in different countries. This study was conducted to determine the magnitude of H.pylori among adult patients with dyspepsia attending the gastroenterology unit at Bugando medical centre. METHODS: A cross sectional study involving 202 dyspeptic patients was conducted between June and July 2014. A Standardized data collection tool was used to collect socio-demographic characteristics. H...
September 2016: African Health Sciences
https://www.readbyqxmd.com/read/27916772/slow-progression-of-gastric-adenocarcinoma-of-fundic-gland-type-a-case-report
#20
Chiaki Kusumoto, Kenji Shigehara, Susumu Take, Kuniharu Ishiki, Kouhei Taniguchi
Here we report the case of a 73-year-old male who had undergone esophagogastroduodenoscopy (EGD) at a nearby hospital or at our hospital every year since 2006. In 2013, EGD results revealed a discolored lesion, measuring 6mm in diameter, on the anterior side of the upper body in the stomach. Helicobacter pylori (HP) was eradicated in 2010, and the background mucosa around the lesion was endoscopically diagnosed as non-atrophic. We performed endoscopic biopsy of the lesion. Histological examination of the specimen confirmed gastric adenocarcinoma of the fundic gland type...
2016: Nihon Shokakibyo Gakkai Zasshi, the Japanese Journal of Gastro-enterology
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