Read by QxMD icon Read


Mostefa Moubri, Christophe Burucoa, Nicolas Kalach, R Rezki Larras, Nouria Nouar, Fawsia Mouffok, Zakia Arrada
We aimed to evaluate in an Algerian pediatric population the diagnostic performances of the IDEIA HpStAR noninvasive stool antigen test (Oxoid, Cambridge, UK) to detect Helicobacter pylori infection before and after eradication therapy. A prospective study including 158 symptomatic Algerian children was conducted. Patients were initially diagnosed with invasive (culture, histology, and rapid urease test) and noninvasive tests (urea breath test and IDEIA HpStAR test). Infected patients were treated, and 101 were controlled after treatment with two invasive (culture and histology) and two noninvasive tests (urea breath test and IDEIA HpStAR test)...
July 10, 2018: Journal of Tropical Pediatrics
Qi Liu, Wei-Kang Shi, Shen-Zhen Ren, Wei-Wei Ni, Wei-Yi Li, Hui-Min Chen, Pei Liu, Jing Yuan, Xiao-Su He, Jia-Jia Liu, Peng Cao, Pu-Zhen Yang, Zhu-Ping Xiao, Hai-Liang Zhu
A novel series of aniline-containing hydroxamic acids were designed, synthesized and evaluated as anti-virulence agents for the treatment of gastritis and gastric ulcer caused by Helicobacter pylori. In vitro enzyme-based screen together with in vivo assays and structure-activity relationship (SAR) studies led to the discovery of three potent urease inhibitors 3-(3,5-dichlorophenylamino)N-hydroxypropanamide (3a), 3-(2-chlorophenylamino)N-hydroxypropanamide (3d) and 3-(2,4-dichlorophenylamino)N-hydroxypropanamide (3n)...
July 2, 2018: European Journal of Medicinal Chemistry
Araceli Benavides-Ward, Fernando Vasquez-Achaya, Wilmer Silva-Caso, Miguel Angel Aguilar-Luis, Fernando Mazulis, Numan Urteaga, Juana Del Valle-Mendoza
OBJECTIVE: To determine the variations in the composition of the intestinal microbiota in asymptomatic children infected with Helicobacter pylori in comparison with children without the infection. RESULTS: Children infected with H. pylori doubled their probability of presenting 3 of 9 genera of bacteria from the gut microbiota, including: Proteobacteria (p = 0.008), Clostridium (p = 0.040), Firmicutes (p = 0.001) and Prevotella (p = 0.006) in comparison to patients without the infection...
July 13, 2018: BMC Research Notes
Haige Huang, Jun Tian, Xin Xu, Qiong Liang, Xusen Huang, Jiaming Lu, Yongliang Yao
PURPOSE: To observe the infection rates of Helicobacter pylori (HP) in bile reflux gastritis (BRG) and gastric cancer and the clinical significance of HP eradication in BRG and gastric cancer patients complicated with HP. METHODS: 248 patients diagnosed with BRG and gastric cancer via gastroscopy were enrolled in this study. HP detection and infection rates of HP were evaluated. Then, BRG and gastric cancer patients complicated with HP were randomly divided into BRG group 1, BRG group 2, gastric cancer group 1 and gastric cancer group 2...
May 2018: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
Natalie J Bitto, Paul J Baker, Jennifer K Dowling, Georgie Wray-McCann, Amanda De Paoli, Le Son Tran, Pak Ling Leung, Katryn J Stacey, Ashley Mansell, Seth L Masters, Richard L Ferrero
Outer membrane vesicles (OMVs) are constitutively produced by Gram-negative bacteria both in vivo and in vitro. These lipid-bound structures carry a range of immunogenic components derived from the parent cell, which are transported into host target cells and activate the innate immune system. Recent advances in the field have shed light on some of the multifaceted roles of OMVs in host-pathogen interactions. In this study, we investigated the ability of OMVs from two clinically important pathogens, Pseudomonas aeruginosa and Helicobacter pylori, to activate canonical and non-canonical inflammasomes...
July 12, 2018: Immunology and Cell Biology
Baris Yilmaz, Huseyin Koseoglu, Yusuf Coskun, Murat Deveci, Murat Kekilli
Introduction: Helicobacter pylori infection is encountered in more than 50% of the world population. A high rate of clarithromycin resistance is observed among Helicobacter pylori strains in some regions because clarithromycin is a drug commonly used for the treatment of other infections. Aim: To identify an efficient eradication protocol for patients infected with H. pylori and to suggest an alternative first-line therapy particularly in countries with high clarithromycin resistance...
2018: Przegla̜d Gastroenterologiczny
Aleksander Szadkowski, Magdalena Zemlak, Jacek Muszyński
Introduction: The treatment of Helicobacter pylori (HP) tends to be empirical despite a high number of failures (over 20%). The efficacy of eradication therapies is declining, reaching in some countries 60%, which correlates inversely with the growing drug resistance of the bacteria. Aim: Given the frequent inefficacy of the hitherto proposed treatment schemes for HP infection, an attempt was made to assess the efficacy of a therapy based on the antibiotic resistance of the cultured bacteria, and to analyse factors with possible contribution to the inefficacy of HP eradication treatment...
2018: Przegla̜d Gastroenterologiczny
Dae Bum Kim, Woo Chul Chung
No abstract text is available yet for this article.
July 13, 2018: Clinical Endoscopy
Livia Archibugi, Marianna Signoretti, Gabriele Capurso
Many risk factors for pancreatic cancer are related with microbiome alteration. In the past few years, the human microbiome and its relation with the immune system have been linked with carcinogenesis of different organs distant from the gut, including the pancreas. Patterns of oral microbiome associated with periodontitis are associated with an increased risk of pancreatic cancer, possibly because of the increased systemic inflammatory response, or to the capacity of some specific bacteria to alter the host immune response, making it more favorable to cancer cells...
July 11, 2018: Journal of Clinical Gastroenterology
Wolfgang Fischbach, Peter Malfertheiner
BACKGROUND: Infection with Helicobacter pylori (H. pylori) is a major pathogenic factor for gastroduodenal ulcer disease and gastric carcinoma, as well as for other types of gastric and extragastric disease. As a result of changing epidemiologic conditions (e.g., immigration), changing resistance patterns with therapeutic implications, and new knowledge relating to the indications for pathogen eradication, the medical management of H. pylori is a dynamic process in need of periodic reassessment...
June 22, 2018: Deutsches Ärzteblatt International
Xingzhe Yang
BACKGROUND: Rosacea is an inflammatory disease affecting the central part of face characterized by persistent or recurrent episodes of erythema, papules, pustules and telangiectasias of unknown etiology. Helicobacter pylori (H. pylori) is a gram-negative bacillus, which is one of the main causes of chronic gastritis, gastric cancer and gastrointestinal ulcers. Recent evidences have suggested that H. pylori infection is closely related to the occurrence of diseases. In recent years, studies have found that Helicobacter pylori infection is associated with the occurrence of acne rosacea...
July 11, 2018: BMC Infectious Diseases
Fanny Coppens, Gaetano Castaldo, Ayla Debraekeleer, Suresh Subedi, Kristof Moonens, Alvin Lo, Han Remaut
The human stomach pathogen Helicobacter pylori attaches to healthy and inflamed gastric tissue through members of a paralogous family of "Helicobacter outer membrane proteins" (Hops), including adhesins BabA, SabA, HopQ, LabA and HopZ. Hops share a conserved 25 kDa C-terminal region that is thought to form an autotransporter-like transmembrane domain. Instead, our results show that Hops contain a non-continuous transmembrane domain, composed of seven predicted β-strands at the C-terminus and one at the N-terminus...
July 11, 2018: Molecular Microbiology
Sanjida Halim Topa, Sujatha Subramoni, Enzo A Palombo, Peter Kingshott, Scott A Rice, Linda L Blackall
Bacterial biofilms can cause serious health care complications associated with increased morbidity and mortality. There is an urge to discover and develop new biofilm inhibitors from natural products or by modifying natural compounds or understanding the modes of action of existing compounds. Cinnamaldehyde (CAD), one of the major components of cinnamon oil, has been demonstrated to act as an antimicrobial agent against a number of Gram-negative and Gram-positive pathogens, including Pseudomonas aeruginosa, Helicobacter pylori and Listeria monocytogenes...
July 12, 2018: Microbiology
Lan Liu, Hongwei Gao, Hongjuan Wang, Weihua Yu, Kongxi Zhu, Yuan Zhang, Jianqiang Guo
BACKGROUND The effects of Helicobacter pylori (H. pylori) infection on gastroesophageal reflux disease (GERD) remain unclear. The aim of this study was to compare the results of clinical esophageal function tests and the effect of H. pylori infection on GERD. MATERIAL AND METHODS A prospective clinical study included 124 patients diagnosed with GERD (four grades). H. pylori infection was determined by gastroscopy and a rapid urease test (RUT) to divide patients into an HP-positive and an HP-negative group. Esophageal function tests included high-resolution manometry (HRM), peristalsis break (PB), and 24-hour pH monitoring (composite pH DeMeester score)...
July 11, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
Hirotaka Nakashima, Hiroshi Kawahira, Hiroshi Kawachi, Nobuhiro Sakaki
Background: Deep learning is a type of artificial intelligence (AI) that imitates the neural network in the brain. We generated an AI to diagnose Helicobacter pylori ( H. pylori ) infection using blue laser imaging (BLI)-bright and linked color imaging (LCI). The aim of this pilot study was to establish an AI diagnosing system that predicts H. pylori infection status using endoscopic images to improve the accuracy and productivity of endoscopic examination. Methods: A total of 222 enrolled subjects (105 H...
July 2018: Annals of Gastroenterology: Quarterly Publication of the Hellenic Society of Gastroenterology
Kwok Ho Lam, Chaolun Xue, Kailei Sun, Huawei Zhang, Wendy Wai Ling Lam, Zeyu Zhu, Juliana Tsz Yan Ng, William E Sause, Paphavee Lertsethtakarn, Kwok-Fai Lau, Karen M Ottemann, Shannon Wing Ngor Au
Bacterial flagella are rotary nano-machines that contribute to bacterial fitness in many settings, including host colonization. The flagellar motor relies on the multiprotein flagellar motor-switch complex to govern flagellum formation and rotational direction. Different bacteria exhibit great diversity in their flagellar motors. One such variation is exemplified by the motor-switch apparatus of the gastric pathogen Helicobacter pylori , which carries an extra switch protein, FliY, along with the more typical FliG, FliM, and FliN proteins...
July 10, 2018: Journal of Biological Chemistry
Michael McFarlane, Alexander Bashford, Shatrughan Sah, Ben R Disney
Amyloidosis a rare disorder characterised by the deposition of amyloid protein aggregates in different organ systems throughout the body with resulting functional impairment of affected organs. It can present with localised or multisystemic deposits. Diagnosis is often delayed due to the non-specific nature of the symptoms. We present the case of a 59-year-old man with a 12-month history of non-specific symptoms. Investigations revealed Helicobacter pylori positive gastritis. Blood tests showed only a normocytic anaemia and thrombocytopaenia...
July 10, 2018: BMJ Case Reports
Alessia Savoldi, Elena Carrara, David Y Graham Prof, Michela Conti, Evelina Tacconelli
BACKGROUND & AIMS: In 2017, the World Health Organization (WHO) designated clarithromycin-resistant Helicobacter pylori a high priority for antibiotic research and development. However, there are no clear data on the global distribution of resistance or its clinical effects. We performed a systematic review and meta-analysis to assess the distribution of H pylori resistance to commonly used antibiotics and to measure the association between antibiotic resistance and treatment failure...
July 7, 2018: Gastroenterology
Mohammed Safwan Ali Khan, Syeda Umme Kulsoom Khundmiri, Syeda Rukhaiya Khundmiri, Mohammad M Al-Sanea, Pooi Ling Mok
Ulceration in the stomach develops in peptic ulcer disease when there is a loss of protective mucosal layers, particularly in Helicobacter pylori infection. Antibiotic therapy has failed to eradicate and impede the colonization of H. pylori . Despite given treatment, recurrent bleeding can occur and lead to death in the affected individual. The disease progression is also related to the non-steroidal inflammatory drug and stress. There are extensive research efforts to identify the gastroprotective property from various alkaloids, flavonoids, and tannins compounds from plants and marine...
2018: Frontiers in Pharmacology
Ujjal Poddar
Background In adults, Helicobacter pylori is aetiologically associated with peptic ulcer disease and gastric cancer. However, the relationship between this bacteria and gastro-intestinal symptoms in children is less clear. Aims To review the recent literature on H. pylori in children and to outline the approach to diagnosis and management. Methods The English language literature was searched for articles on H. pylori in children. Special attention was paid to prevalence, diagnosis and management pertinent to low- and middle-income countries (LMIC)...
July 10, 2018: Paediatrics and International Child Health
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"