keyword
https://read.qxmd.com/read/38498080/rgd-coated-polymeric-microbubbles-promote-ultrasound-mediated-drug-delivery-in-an-inflamed-endothelium-pericyte-co-culture-model-of-the-blood-brain-barrier
#1
JOURNAL ARTICLE
Christopher Hark, Junlin Chen, Julia Blöck, Eva Miriam Buhl, Harald Radermacher, Robert Pola, Michal Pechar, Tomáš Etrych, Quim Peña, Anne Rix, Natascha I Drude, Fabian Kiessling, Twan Lammers, Jan-Niklas May
Drug delivery to central nervous pathologies is compromised by the blood-brain barrier (BBB). A clinically explored strategy to promote drug delivery across the BBB is sonopermeation, which relies on the combined use of ultrasound (US) and microbubbles (MB) to induce temporally and spatially controlled opening of the BBB. We developed an advanced in vitro BBB model to study the impact of sonopermeation on the delivery of the prototypic polymeric drug carrier pHPMA as a larger molecule and the small molecule antiviral drug ribavirin...
March 18, 2024: Drug Delivery and Translational Research
https://read.qxmd.com/read/38495914/immobilizing-c-rgdfc-on-the-surface-of-metal-phenolic-networks-by-thiol-click-reaction-for-accelerating-osteointegration-of-implant
#2
JOURNAL ARTICLE
Zeyu Shou, Zhibiao Bai, Kaiyuan Huo, Shengwu Zheng, Yizhe Shen, Han Zhou, Xiaojing Huang, Hongming Meng, Chenwei Xu, Shaohao Wu, Na Li, Chun Chen
The limited osteointegration often leads to the failure of implant, which can be improved by fixing bioactive molecules onto the surface, such as arginyl-glycyl-aspartic acid (RGD): a cell adhesion motif. Metal-Phenolic Networks (MPNs) have garnered increasing attention from different disciplines in recent years due to their simple and rapid process for depositing on various substrates or particles with different shapes. However, the lack of cellular binding sites on MPNs greatly blocks its application in tissue engineering...
April 2024: Materials today. Bio
https://read.qxmd.com/read/38490483/zirconium-containing-nanoscale-coordination-polymers-for-positron-emission-tomography-and-fluorescence-guided-cargo-delivery-to-triple-negative-breast-tumors
#3
JOURNAL ARTICLE
Yan-Ping Li, Zi-Wen Pan, Yan-Jun Jiang, Ya-Yun Peng, Ting Cai, Hao Hong, Xiao-Feng Wang
Nanoscale coordination polymer (NCP) is a class of hybrid materials formed by self-assembly of metal ions and organic ligands through coordination. The applications of NCP in biomedicine are quite extensive due to the diversity choice of metal ions and organic ligands. Here we designed Zr-P1 NCP based on Zr4+ selected as metal ion nodes and tetrakis(4-carboxyphenyl) ethylene as bridging ligands. Zr-P1 NCP was modified with functionalized pyrene derived polyethylene glycol (Py-PAA-PEG-Mal) on the surface and further conjugated with cRGD for active targeting of integrin αv β3 overexpressed in triple-negative breast cancer...
March 13, 2024: Acta Biomaterialia
https://read.qxmd.com/read/38484514/magnetic-colloidal-nanoformulations-to-remotely-trigger-mechanotransduction-for-osteogenic-differentiation
#4
JOURNAL ARTICLE
Manuel Estévez, Mónica Cicuéndez, Montserrat Colilla, María Vallet-Regí, Blanca González, Isabel Izquierdo-Barba
Nowadays, diseases associated with an ageing population, such as osteoporosis, require the development of new biomedical approaches to bone regeneration. In this regard, mechanotransduction has emerged as a discipline within the field of bone tissue engineering. Herein, we have tested the efficacy of superparamagnetic iron oxide nanoparticles (SPIONs), obtained by the thermal decomposition method, with an average size of 13 nm, when exposed to the application of an external magnetic field for mechanotransduction in human bone marrow-derived mesenchymal stem cells (hBM-MSCs)...
March 8, 2024: Journal of Colloid and Interface Science
https://read.qxmd.com/read/38483292/on-demand-bioactivation-of-inert-materials-with-plasma-polymerized-nanoparticles
#5
JOURNAL ARTICLE
Miguel Santos, Praveesuda L Michael, Timothy Mitchell, Yuen Lam, Thomas Robinson, Mathew Moore, Richard P Tan, Jelena Rnjak-Kovacina, Khoon S Lim, Steven G Wise
Conventional gas plasma treatments are crucial for functionalizing materials in biomedical applications, but have limitations that hinder their broader use. These methods require exposure to reactive media under vacuum conditions, rendering them unsuitable for substrates that demand aqueous environments, such as proteins and hydrogels. Additionally, complex geometries are difficult to treat, necessitating extensive customization for each material and shape. To address these constraints, we propose an innovative approach employing plasma polymer nanoparticles (PPN) as a versatile functionalisation tool...
March 14, 2024: Advanced Materials
https://read.qxmd.com/read/38475352/effect-of-functionalization-of-texturized-polypropylene-surface-by-silanization-and-hbii-rgd-attachment-on-response-of-primary-abdominal-and-vaginal-fibroblasts
#6
JOURNAL ARTICLE
Maria Teresa Quiles, Alejandra Rodríguez-Contreras, Jordi Guillem-Marti, Miquel Punset, Miguel Sánchez-Soto, Manuel López-Cano, Jordi Sabadell, Janice Velasco, Manuel Armengol, Jose Maria Manero, Maria Antònia Arbós
Soft tissue defects, such as incisional hernia or pelvic organ prolapse, are prevalent pathologies characterized by a tissue microenvironment rich in fragile and dysfunctional fibroblasts. Precision medicine could improve their surgical repair, currently based on polymeric materials. Nonetheless, biomaterial-triggered interventions need first a better understanding of the cell-material interfaces that truly consider the patients' biology. Few tools are available to study the interactions between polymers and dysfunctional soft tissue cells in vitro...
February 29, 2024: Polymers
https://read.qxmd.com/read/38460368/intra-abdominal-transplantation-of-plga-pcl-m13-phage-electrospun-scaffold-induces-self-assembly-of-lymphoid-tissue-like-structure
#7
JOURNAL ARTICLE
Zohreh Safari, Majid Sadeghizadeh, Ahmad Zavaran Hosseini, Ali Hazrati, Sara Soudi
Lymphoid organs are the main structural components of the immune system. In the current research, the mixture of poly lactic-co-glycolic acid (PLGA), polycaprolactone (PCL), and M13 phage or its RGD-modified form was used in the construction of a fibrillar scaffold using the electrospinning method. The constructs were transplanted intra-abdominally and examined for the formation of lymphoid-like tissues at different time intervals. The confocal and scanning electron microscopy demonstrate that M13 phage-containing scaffolds provide a suitable environment for lymph node-isolated fibroblasts...
March 8, 2024: Biomedicine & Pharmacotherapy
https://read.qxmd.com/read/38454012/staphylococcal-superantigen-like-protein-3-triggers-murine-mast-cell-adhesion-by-binding-to-cd43-and-augments-mast-cell-activation
#8
JOURNAL ARTICLE
Sae Kawano, Chisaki Noda, Saotomo Itoh, Ayaka Urabe, Chifumi Fujii, Isamu Ogawa, Ryo Suzuki, Shigeaki Hida
Staphylococcus aureus is a noteworthy pathogen in allergic diseases, as four staphylococcal exotoxins activate mast cells, a significant contributor to inflammation, in an IgE-independent manner. Although the adhesion of mast cells is an essential process for their immune responses, only a small number of exotoxins have been reported to affect the process. Here, we demonstrated that staphylococcal superantigen-like (SSL) 3, previously identified as a toll-like receptor 2 agonist, induced the adhesion of murine bone marrow-derived mast cells to culture substratum...
March 7, 2024: Genes to Cells: Devoted to Molecular & Cellular Mechanisms
https://read.qxmd.com/read/38446101/nanoparticles-traversing-the-extracellular-matrix-induce-biophysical-perturbation-of-fibronectin-depicted-by-surface-chemistry
#9
JOURNAL ARTICLE
Xing Guo, Lin Yang, Chaofan Deng, Luyao Ren, Shixin Li, Xianren Zhang, Jian Zhao, Tongtao Yue
While the filtering and accumulation effects of the extracellular matrix (ECM) on nanoparticles (NPs) have been experimentally observed, the detailed interactions between NPs and specific biomolecules within the ECM remain poorly understood and pose challenges for in vivo molecular-level investigations. Herein, we adopt molecular dynamics simulations to elucidate the impacts of methyl-, hydroxy-, amine-, and carboxyl-modified gold NPs on the cell-binding domains of fibronectin (Fn), an indispensable component of the ECM for cell attachment and signaling...
March 6, 2024: Nanoscale
https://read.qxmd.com/read/38445350/prospective-evaluation-of-68ga-nodaga-rgd-pet-ct-in-patients-of-carcinoma-thyroid-with-thyroglobulin-elevated-negative-radioiodine-scintigraphy-tenis-with-a-head-to-head-comparison-with-fdg-pet-ct
#10
JOURNAL ARTICLE
Abhay Gondhane, Priyanka Verma, Ashok Chandak, Sandip Basu
BACKGROUND AND AIM: This study aimed to examine the expression of RGD binding integrins in patients of elevated serum thyroglobulin (Tg) level with negative radioiodine scintigraphy (TENIS) employing 68Ga-NODAGA-RGD PET-CT. MATERIAL AND METHODS: This was a prospective study involving 30 proven cases of TENIS with histopathological diagnosis of differentiated thyroid carcinoma post-surgery. In addition to observing the lesional concentration on 68Ga-NODAGA-RGD PET-CT, a 4-point visual grading system (grade I-IV), was undertaken to estimate the degree of radiotracer avidity, for potential of theranostics...
March 6, 2024: Nuclear Medicine Communications
https://read.qxmd.com/read/38442832/heterogeneous-nucleation-induced-a-pernyi-b-mori-silk-fibroin-coatings-on-az31-biometals-with-enhanced-corrosion-resistance-adhesion-and-biocompatibility
#11
JOURNAL ARTICLE
Xinru Cao, Yanning Chen, Chen Zhang, Zhinan Mao, Jingwu Zhang, Tingji Ma, Wenhan Tian, Xiangsheng Kong, Haotong Li, Sixian Rao, Kang Yang
Silk fibroin coatings on biomedical magnesium alloys have garnered significant attention due to their enhanced corrosion resistance and biocompatibility. However, the utilization of wild A. pernyi silk fibroin, known for its RGD sequence that facilitates tissue regeneration, presents a challenge for corrosion-resistant coatings on magnesium alloys due to its weak adhesion and high dissolution rate. In this study, we employed hexafluoroisopropanol as a solvent to blend A. pernyi silk fibroin with B. mori silk fibroin...
March 3, 2024: International Journal of Biological Macromolecules
https://read.qxmd.com/read/38434851/experimental-study-on-rapid-hemostasis-using-peptide-hydrogels
#12
JOURNAL ARTICLE
Linru Zeng, Gan Luo, Zhenshuang Yue, Yanghua Tang, Zhetian Wang, Yitie Chang
Uncontrolled hemorrhaging resulting from trauma, surgery, and disease-associated or drug-induced blood disorders can cause significant morbidities and mortalities in civilian and military populations. Self-assembling peptide nanofibers are particularly attractive due to their rapid and efficient hemostasis, biocompatibility, and wound-healing properties. In this study, we designed two types of 12-residue peptides by using a strong fishnet-like peptide sequence and a pro-cell adhesion sequence (Arg-Gly-Asp, RGD)...
February 27, 2024: ACS Omega
https://read.qxmd.com/read/38433552/3d-printing-of-gellan-dextran-methacrylate-ipns-in-glycerol-and-their-bioadhesion-by-rgd-derivatives
#13
JOURNAL ARTICLE
Luca Paoletti, Francesco Baschieri, Claudia Migliorini, Chiara Di Meo, Olivier Monasson, Elisa Peroni, Pietro Matricardi
The ever-growing need for new tissue and organ replacement approaches paved the way for tissue engineering. Successful tissue regeneration requires an appropriate scaffold, which allows cell adhesion and provides mechanical support during tissue repair. In this light, an interpenetrating polymer network (IPN) system based on biocompatible polysaccharides, dextran (Dex) and gellan (Ge), was designed and proposed as a surface that facilitates cell adhesion in tissue engineering applications. The new matrix was developed in glycerol, an unconventional solvent, before the chemical functionalization of the polymer backbone, which provides the system with enhanced properties, such as increased stiffness and bioadhesiveness...
March 3, 2024: Journal of Biomedical Materials Research. Part A
https://read.qxmd.com/read/38431093/smart-exosomes-enhance-pdac-targeted-therapy
#14
JOURNAL ARTICLE
Justin F Creeden, Jonathan Sevier, Jian-Ting Zhang, Yakov Lapitsky, F Charles Brunicardi, Ge Jin, John Nemunaitis, JingYuan Liu, Andrea Kalinoski, Donald Rao, Shi-He Liu
Exosomes continue to attract interest as a promising nanocarrier drug delivery technology. They are naturally derived nanoscale extracellular vesicles with innate properties well suited to shuttle proteins, lipids, and nucleic acids between cells. Nonetheless, their clinical utility is currently limited by several major challenges, such as their inability to target tumor cells and a high proportion of clearance by the mononuclear phagocyte system (MPS) of the liver and spleen. To overcome these limitations, we developed "Smart Exosomes" that co-display RGD and CD47p110-130 through CD9 engineering (ExoSmart )...
February 29, 2024: Journal of Controlled Release
https://read.qxmd.com/read/38430913/an-autologous-ex%C3%A2-vivo-model-for-exploring-patient-specific-responses-to-viro-immunotherapy-in-glioblastoma
#15
JOURNAL ARTICLE
Eftychia Stavrakaki, Wouter B L van den Bossche, Lisette B Vogelezang, Cristina Teodosio, Dana M Mustafa, Jacques J M van Dongen, Clemens M F Dirven, Rutger K Balvers, Martine L Lamfers
Oncolytic virus (OV) clinical trials have demonstrated remarkable efficacy in subsets of patients with glioblastoma (GBM). However, the lack of tools to predict this response hinders the advancement of a more personalized application of OV therapy. In this study, we characterize an ex vivo co-culture system designed to examine the immune response to OV infection of patient-derived GBM neurospheres in the presence of autologous peripheral blood mononuclear cells (PBMCs). Co-culture conditions were optimized to retain viability and functionality of both tumor cells and PBMCs, effectively recapitulating the well-recognized immunosuppressive effects of GBM...
February 27, 2024: Cell Rep Methods
https://read.qxmd.com/read/38430834/au-fe-3-o-4-janus-nanoparticles-for-imaging-guided-near-infrared-enhanced-ferroptosis-therapy-in-triple-negative-breast-cancer
#16
JOURNAL ARTICLE
Ruixue Wei, Gaoliang Fu, Zhe Li, Yang Liu, Lingxiao Qi, Kun Liu, Zhenghuan Zhao, Mengzhou Xue
Triple-negative breast cancer (TNBC) is insensitive to conventional therapy due to its highly invasive nature resulting in poor therapeutic outcomes. Recent studies have shown multiple genes associated with ferroptosis in TNBC, suggesting an opportunity for ferroptosis-based treatment of TNBC. However, the efficiency of present ferroptosis agents for cancer is greatly restricted due to lack of specificity and low intracellular levels of H2 O2 in cancer cells. Herein, we report a nano-theranostic platform consisting of gold (Au)-iron oxide (Fe3 O4 ) Janus nanoparticles (GION@RGD) that effectively enhances the tumor-specific Fenton reaction through utilization of near-infrared (NIR) lasers, resulting in the generation of substantial quantities of toxic hydroxyl radicals (•OH)...
February 29, 2024: Journal of Colloid and Interface Science
https://read.qxmd.com/read/38418564/enhanced-bone-regeneration-in-rat-calvarial-defects-through-bmp2-release-from-engineered-poly-ethylene-glycol-hydrogels
#17
JOURNAL ARTICLE
Queralt Vallmajo-Martin, Christopher Millan, Ralph Müller, Franz E Weber, Martin Ehrbar, Chafik Ghayor
The clinical standard therapy for large bone defects, typically addressed through autograft or allograft donor tissue, faces significant limitations. Tissue engineering offers a promising alternative strategy for the regeneration of substantial bone lesions. In this study, we harnessed poly(ethylene glycol) (PEG)-based hydrogels, optimizing critical parameters including stiffness, incorporation of arginine-glycine-aspartic acid (RGD) cell adhesion motifs, degradability, and the release of BMP2 to promote bone formation...
February 28, 2024: Scientific Reports
https://read.qxmd.com/read/38417028/a-combination-of-flexible-modified-plant-virus-nanoparticles-enables-additive-effects-resulting-in-improved-osteogenesis
#18
JOURNAL ARTICLE
Juliane Schuphan, Natalija Stojanovi, Ying-Ying Lin, Eva Miriam Buhl, Sanja Aveic, Ulrich Commandeur, Stefan Schillberg, Horst Fischer
Plant virus nanoparticles (VNPs) genetically engineered to present osteogenic cues provide a promising method for biofunctionalizing hydrogels in bone tissue engineering. Flexible Potato virus X (PVX) nanoparticles substantially enhance the attachment and differentiation of human mesenchymal stem cells (hMSCs) by presenting the RGD motif, hydroxyapatite-binding peptide (HABP), or consecutive polyglutamates (E8) in a concentration-dependent manner. Therefore, it was hypothesized that Tobacco mosaic virus (TMV) nanoparticles, which present 1...
February 28, 2024: Advanced Healthcare Materials
https://read.qxmd.com/read/38412413/ph-responsive-self-assembled-ruthenium-nanodrug-dual-impact-on-lysosomes-and-dna-for-synergistic-chemotherapy-and-immunogenic-cell-death
#19
JOURNAL ARTICLE
Yu Lu, Di Zhu, Bo Hu, Rong Chen, Xin Wang, Xiaoxue Xu, Wenjing Wang, Hao Wu, Yuji Wang
Several DNA-damaging antitumor agents, including ruthenium complexes, induce immunogenic cell death (ICD). In this study, an arginyl-glycyl-aspartic acid (RGD) peptide-modified carboline ruthenium complex (KS-Ru) is synthesized as a chemotherapeutic nanodrug and an ICD inducer. The RGD peptide, an integrin ligand, provides tumor-specific targeting and promotes self-assembly of the KS-Ru complex. The pH-responsive self-assembly is assessed through transmission and scanning electron microscopy. Additionally, in vitro cytotoxic activity and anti-metastasis ability are evaluated using MTT and Transwell assays, respectively, along with cellular immunofluorescence staining and imaging flow cytometry...
February 27, 2024: Small
https://read.qxmd.com/read/38409731/development-of-64cu-cu-nodaga-rgd-bbn-as-a-novel-radiotracer-for-dual-integrin-and-grpr-targeted-tumor-pet-imaging
#20
JOURNAL ARTICLE
Naeimeh Amraee, Behrouz Alirezaour, Mohammad Hosntalab, Asghar Hadadi, Hassan Yousefnia
BACKGROUND: In this study, [64Cu]Cu-NODAGA-RGD-BBN was prepared and its preclinical assessments were evaluated for PET imaging of GRPR overexpressing tumors. METHODS: NODAGA-RGD-BBN heterodimer peptide was successfully labeled with cyclotronproduced copper-64 at optimized conditions. The radiochemical purity of the radiotracer was checked by HPLC and RTLC methods. The stability of the radiolabeled compound was assessed in PBS (4°C) and in human blood serum (37°C)...
February 22, 2024: Current Radiopharmaceuticals
keyword
keyword
27894
1
2
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.