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https://www.readbyqxmd.com/read/28319669/cell-adhesion-on-dynamic-supramolecular-surfaces-probed-by-fluid-force-microscopy-based-single-cell-force-spectroscopy
#1
Shrikrishnan Sankaran, Leena Jaatinen, Jenny Brinkmann, Tomaso Zambelli, Janos Vörös, Pascal Jonkheijm
Biomimetic and stimuli-responsive cell-material interfaces are actively being developed to study and control various cell-dynamics phenomena. Since cells naturally reside in the highly dynamic and complex environment of the extracellular matrix, attempts are being made to replicate these conditions in synthetic biomaterials. Supramolecular chemistry, dealing with non-covalent interactions, has recently provided possibilities to incorporate such dynamicity and responsiveness in various types of architectures...
March 20, 2017: ACS Nano
https://www.readbyqxmd.com/read/28315557/oncolytic-viruses-treatment-and-implications-for-patients-with-gliomas%C3%A2
#2
Cheryl Martin
BACKGROUND: Oncolytic viral therapies are increasingly being explored for the treatment of diverse cancer types, most notably melanoma. However, advances in the treatment of high-grade gliomas, and specifically glioblastoma multiforme (GBM), are the result of novel oncolytic viral therapies. Delta-24-RGD is one such therapy that has demonstrated promising results in phase 1 trials.
. OBJECTIVES: The objective of this article is to provide an overview of Delta-24-RGD, highlighting considerations for nurses in diverse clinical, research, and advanced practice roles...
April 1, 2017: Clinical Journal of Oncology Nursing
https://www.readbyqxmd.com/read/28315346/inhibition-of-osteoporosis-by-the-%C3%AE-v%C3%AE-3-integrin-antagonist-of-rhodostomin-variants
#3
Tzu-Hung Lin, Rong-Sen Yang, Huang-Ju Tu, Houng-Chi Liou, Yen-Ming Lin, Woie-Jer Chuang, Wen-Mei Fu
Integrins are heterodimeric cell surface receptors that mediate cell-cell and cell-matrix interaction. The vitronectin and osteopontin receptor αvβ3 integrin has increased expression levels and is implicated in the adhesion, activation, and migration of osteoclasts on the bone surface as well as osteoclast polarization. αvβ3 integrin plays an important role in osteoclast differentiation and resorption. In addition, Arg-Gly-Asp (RGD)-containing peptides, small molecular inhibitors, and antibodies to αvβ3 integrin have been shown to inhibit bone resorption in vitro and in vivo...
March 14, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/28301223/antitumor-effect-of-nanoparticle-131-i-labeled-arginine-glycine-aspartate-bovine-serum-albumin-polycaprolactone-in-lung-cancer
#4
Hui Ming, Lei Fang, Jingmei Gao, Chengxia Li, Yanhui Ji, Yiming Shen, Yiming Hu, Ning Li, Jin Chang, Wei Li, Jian Tan
OBJECTIVE: The aim of the present study is to investigate the biologic effects of internal irradiation and the therapeutic effectiveness of (131)I-labeled arginine-glycine-aspartate (RGD)-bovine serum albumin (BSA)-polycaprolactone (PCL) ((131)I-RGD-BSA-PCL) in murine lung cancer models. MATERIALS AND METHODS: The target binding and cellular uptake of NCI-H460 lung cancer cells overexpressing integrin αvβ3 were observed by confocal microscopy. Flow cytometry was used to assay apoptosis...
March 16, 2017: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/28296389/abrogated-cell-contact-guidance-on-amino-functionalized-microgrooves
#5
Caroline Mörke, Henrike Rebl, Birgit Finke, Manuela Dubs, Peter Nestler, Aissam Airoudj, Vincent Roucoules, Matthias Schnabelrauch, Andreas Körtge, Karine Anselme, Christiane A Helm, J Barbara Nebe
Topographical and chemical features of biomaterial surfaces affect the cell physiology at the interface and are promising tools for the improvement of implants. The dominance of the surface topography on cell behavior is often accentuated. Striated surfaces induce an alignment of cells and their intracellular adhesion-mediated components. Recently, it could be demonstrated that a chemical modification via plasma polymerized allylamine was not only able to boost osteoblast cell adhesion and spreading but also override the cell alignment on stochastically machined titanium...
March 15, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28293947/water-solubilizing-hydrophobic-znaginse-zns-qds-with-tumor-targeted-crgd-sulfobetaine-pima-histamine-ligands-via-a-self-assembly-strategy-for-bio-imaging
#6
Tao Deng, Yanan Peng, Rong Zhang, Jie Wang, Jie Zhang, Yue-Qing Gu, Dechun Huang, Dawei Deng
Exploring the organic-to-aqueous phase transfer of quantum dots (QDs) is significant for achieving their versatile applications in biomedαical fields. In this thematic issue, surface modification, size control and biocompatibility of QDs and QDs-based nanocomposites are core problems. Herein, the new highly fluorescent tumor-targeted QDs-clusters consisting of ZnAgInSe/ZnS (ZAISe/ZnS) QDs and sulfobetaine-PIMA-histamine (SPH) polymer with the ανβ3 integrin receptor cyclic RGD (c-RGD) were developed via ligand exchange and an accompanying self-assemble process...
March 15, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28292248/surface-engineered-dendrimers-in-sirna-delivery-and-gene-silencing
#7
Vishakha Tambe, Shreya Thakkar, Nidhi Raval, Dilip Sharma, Kiran Kalia, Rakesh Kumar Tekade
BACKGROUND: Therapeutic efficacy of dreadful diseases like cancer, HIV (Human Immunodeficiency Virus) can be enhanced by delivering molecules which regulate function at gene level rather than at receptor level. Silencing RNA is one such approach recently used to silence target gene expressed diseases; and thereby reduce target protein levels. Many of the non-viral vectors are proved to act as carriers for silencing RNA. Dendrimers being one of them have less size, low poly dispersibility index, water solubility, multivalence, and easy surface modification...
March 14, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28292179/cross-linking-approaches-to-tuning-the-mechanical-properties-of-peptide-%C3%AF-electron-hydrogels
#8
Wathsala Liyanage, Herdeline Ann M Ardoña, Hai-Quan Mao, John D Tovar
Self-assembling peptides are extensively exploited as bioactive materials in applications such as regenerative medicine and drug delivery despite the fact that their relatively weak noncovalent interactions often render them susceptible to mechanical destruction and solvent erosion. Herein, we describe how covalent cross-linking enhances the mechanical stability of self-assembling π-conjugated peptide hydrogels. We designed short peptide-chromophore-peptide sequences displaying different reactive functional groups that can form cross-links with appropriately modified bifunctional polyethylene glycol (PEG)-based small guest molecules...
March 15, 2017: Bioconjugate Chemistry
https://www.readbyqxmd.com/read/28292176/injectable-polypeptide-hydrogel-as-biomimetic-scaffolds-with-tunable-bioactivity-and-controllable-cell-adhesion
#9
Qinghua Xu, Zhen Zhang, Chunsheng Xiao, Chaoliang He, Xuesi Chen
Injectable hydrogels have been widely investigated for applications in biomedical fields, for instance, as biomimetic scaffolds mimicking the extracellular matrix (ECM). In addition to as scaffolds for mechanical support and transferring of nutrients, the dynamic bioactivity of ECM is another critical factor that affects cell behavior. In this work, a novel injectable poly(L-glutamic acid)-based hydrogel decorated with RGD was fabricated. The presentation of RGD significantly enhanced the cell-matrix interaction, and promoted cell adhesion and proliferation...
March 14, 2017: Biomacromolecules
https://www.readbyqxmd.com/read/28291159/67cu-radiolabeling-of-a-multimeric-rgd-peptide-for-%C3%AE-v%C3%AE-3-integrin-targeted-radionuclide-therapy-stability-therapeutic-efficacy-and-safety-studies-in-mice
#10
Zhao-Hui Jin, Takako Furukawa, Tomoyuki Ohya, Mélissa Degardin, Aya Sugyo, Atsushi B Tsuji, Yasuhisa Fujibayashi, Ming-Rong Zhang, Tatsuya Higashi, Didier Boturyn, Pascal Dumy, Tsuneo Saga
OBJECTIVE: Copper-67 (Cu) is one of the most promising radionuclides for internal radiation therapy. Globally, several projects have recently been initiated for developing innovative approaches for the large-scale production of Cu. Encouraged by these, we performed Cu-radiolabeling of a tetrameric cyclic Arg-Gly-Asp (cRGD) peptide conjugate, cyclam-RAFT-c(-RGDfK-)4, which selectively targets αVβ3 integrin (αVβ3), the transmembrane receptor involved in tumor invasion, angiogenesis, and metastasis...
April 2017: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/28285174/a-computational-study-suggests-that-replacing-peg-with-pmoz-may-increase-exposure-of-hydrophobic-targeting-moiety
#11
Aniket Magarkar, Tomasz Róg, Alex Bunker
In a previous study we showed that the cause of failure of a new, proposed, targeting ligand, the AETP moiety, when attached to a PEGylated liposome, was occlusion by the poly(ethylene glycol) (PEG) layer due to its hydrophobic nature, given that PEG is not entirely hydrophilic. At the time we proposed that possible replacement with a more hydrophilic protective polymer could alleviate this problem. In this study we have used computational molecular dynamics modelling, using a model with all atom resolution, to suggest that a specific alternative protective polymer, poly(2-methyloxazoline) (PMOZ), would perform exactly this function...
March 9, 2017: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28285159/hydroxyapatite-reinforced-inherent-rgd-containing-silk-fibroin-composite-scaffolds-promising-platform-for-bone-tissue-engineering
#12
Sibaram Behera, Deboki Naskar, Sunaina Sapru, Promita Bhattacharjee, Tuli Dey, Ananta K Ghosh, Mahitosh Mandal, Subhas C Kundu
Replacement and repair of ectopic bone defects and traumatized bone tissues are done using porous scaffolds and composites. The prerequisites for such scaffolds include high mechanical strength, osseoconductivity and cytocompatibility. The present work is designed to address such requirements by fabricating a reinforced cytocompatible scaffold. Biocompatible silk protein fibroin collected from tropical non-mulberry tasar silkworm (Antheraea mylitta) is used to fabricate fibroin-hydroxyapatite (HAp) nanocomposite particles using chemical precipitation method...
March 8, 2017: Nanomedicine: Nanotechnology, Biology, and Medicine
https://www.readbyqxmd.com/read/28284105/surface-engineering-of-semiconducting-polymer-nanoparticles-for-amplified-photoacoustic-imaging
#13
Xu Zhen, Xiaohua Feng, Chen Xie, Yuanjin Zheng, Kanyi Pu
Despite the deeper tissue penetration of photoacoustic (PA) imaging, its sensitivity is generally lower than optical imaging. This fact partially restricts the applications of PA imaging and greatly stimulates the development of sensitive PA imaging agents. We herein report that the surface coating of semiconducting polymer nanoparticles (SPNs) with the silica layer can simultaneously amplify fluorescence and PA brightness while maintaining their photothermal conversion efficiency nearly unchanged. As compared with the bare SPNs, the silica-coated SPNs (SPNs-SiO2) have higher photothermal heating rate in the initial stage of laser irradiation due to the higher interfacial thermal conductance between the silica layer and water relative to that between the SP and water...
March 6, 2017: Biomaterials
https://www.readbyqxmd.com/read/28281182/evaluation-of-magnetonanoparticles-conjugated-with-new-angiogenesis-peptides-in-intracranial-glioma-tumors-by-mri
#14
Erica Aparecida de Oliveira, Jelena Lazovic, Lea Guo, Horacio Soto, Bluma Linkowski Faintuch, Massoud Akhtari, Whitney Pope
Angiogenesis plays a critical role in progression of malignant gliomas. The development of glioma-specific labeling molecules that can aid detection and visualization of angiogenesis can help surgical planning and improve treatment outcome. The aim of this study was to evaluate if two peptides (GX1 and RGD-GX1) linked to angiogenesis can be used as an MR-imaging markers of angiogenesis. MR imaging was performed in U87 glioblastoma-bearing NOD-SCID mice at different time points between 15 and 120 min post-injection to visualize particle distribution...
March 9, 2017: Applied Biochemistry and Biotechnology
https://www.readbyqxmd.com/read/28280323/enhanced-anticancer-efficacy-of-paclitaxel-through-multistage-tumor-targeting-liposomes-modified-with-rgd-and-kla-peptides
#15
Jiawei Sun, Lei Jiang, Yi Lin, Ethan Michael Gerhard, Xuehua Jiang, Li Li, Jian Yang, Zhongwei Gu
Mitochondria serve as both "energy factories" and "suicide weapon stores" of cells. Targeted delivery of cytotoxic drugs to the mitochondria of tumor cells and tumor vascular cells is a promising strategy to improve the efficacy of chemotherapy. Here, multistage tumor-targeting liposomes containing two targeted peptide-modified lipids, cRGD-PEG2000-DSPE and KLA-PEG2000-DSPE, were developed for encapsulation of the anticancer drug paclitaxel (PTX, RGD-KLA/PTX-Lips). Compared with Taxol (free PTX), RGD/PTX-Lips and KLA/PTX-Lips, the half-maximal inhibitory concentration (IC50) value of RGD-KLA/PTX-Lips in vitro was 1...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28279737/targeting-tumors-with-cyclic-rgd-conjugated-lipid-nanoparticles-loaded-with-an-ir780-nir-dye-in-vitro-and-in-vivo-evaluation
#16
Jungyoon Choi, Emilie Rustique, Maxime Henry, Mélanie Guidetti, Véronique Josserand, Lucie Sancey, Jérôme Boutet, Jean-Luc Coll
Like several 50nm-large nanocarriers, lipid nanoparticles (LNPs) can passively accumulate in tumors through the Enhanced Permeability and Retention effect. In this study, we developed PEGylated LNPs loaded with IR780 iodide as a contrast agent for NIR fluorescence imaging and modified them with cyclic RGD peptides in order to target integrin avβ3. We demonstrate a specific targeting of the receptor with cRGD-LNPs but not with cRAD-LNP and standard LNP using HEK293(β3), HEK293(β3)-αvRFP, DU145 and PC3 cell lines...
March 6, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28278046/multilayered-polyion-complexes-with-dissolvable-silica-layer-covered-by-controlling-densities-of-crgd-conjugated-peg-chains-for-cancer-targeted-sirna-delivery
#17
Mitsuru Naito, Ryota Azuma, Hiroyasu Takemoto, Mao Hori, Naoto Yoshinaga, Shigehito Osawa, Rimpei Kamegawa, Hyun Jin Kim, Takehiko Ishii, Nobuhiro Nishiyama, Kanjiro Miyata, Kazunori Kataoka
Surface functionalization of nanoparticles is a crucial factor for nanoparticle-mediated drug and nucleic acid delivery. Particularly, the density of targeting ligands on nanoparticle significantly affects the affinity of nanoparticles to specific cellular surface (or receptor) through the multivalent binding effect. Herein, multilayered polyion complexes (mPICs) are prepared to possess varying densities of cyclic RGD peptide (cRGD) ligands for cancer-targeted small interfering RNA (siRNA) delivery. A template PIC is first prepared by mixing siRNAs with homo catiomers of N-substituted polyaspartamide bearing tetraethylenepentamine (PAsp(TEP)) in aqueous solution, followed by silica-coating through silicate condensation reaction...
March 12, 2017: Journal of Biomaterials Science. Polymer Edition
https://www.readbyqxmd.com/read/28277676/mechanistic-basis-for-the-binding-of-rgd-and-agdv-peptides-to-the-platelet-integrin-%C3%AE-iib%C3%AE-3
#18
Olga Kononova, Rustem I Litvinov, Dmitry S Blokhin, Vladimir V Klochkov, John W Weisel, Joel S Bennett, Valeri Barsegov
Binding of soluble fibrinogen to the activated conformation of the integrin αIIbβ3 is required for platelet aggregation and is mediated exclusively by the C-terminal AGDV-containing dodecapeptide (γC-12) sequence of the fibrinogen γ chain. However, peptides containing the Arg-Gly-Asp (RGD) sequences located in two places in the fibrinogen Aα chain inhibit soluble fibrinogen binding to αIIbβ3 and make substantial contributions to αIIbβ3 binding when fibrinogen is immobilized and when it is converted to fibrin...
March 9, 2017: Biochemistry
https://www.readbyqxmd.com/read/28269979/in-situ-monitoring-intracellular-structural-change-of-nanovehicles-through-photoacoustic-signals-based-on-phenylboronate-linked-rgd-dextran-purpurin-18-conjugates
#19
Dong-Bing Cheng, Guo-Bin Qi, Jing-Qi Wang, Yong Cong, Fu-Hua Liu, Haijun Yu, Zeng-Ying Qiao, Hao Wang
The stimuli-responsive polymeric nanocarriers have been studied extensively, and their structural changes in cells are important for the controlled intracellular drug release. The present work reported RGD-dextran/purpurin 18 conjugates with pH-responsive phenylboronate as spacer for monitoring the structural change of nanovehicles through ratiometric photoacoustic (PA) signal. Phenylboronic acid modified purpurin 18 (NPBA-P18) could attach onto the RGD-decorated dextran (RGD-Dex), and the resulting RGD-Dex/NPBA-P18 (RDNP) conjugates with different molar ratios of RGD-Dex and NPBA-P18 were prepared...
March 14, 2017: Biomacromolecules
https://www.readbyqxmd.com/read/28261226/transcriptomic-analysis-reveals-new-insights-into-high-temperature-dependent-glume-unclosing-in-an-elite-rice-male-sterile-line
#20
Chongyun Fu, Feng Wang, Wuge Liu, Dilin Liu, Jinhua Li, Manshan Zhu, Yilong Liao, Zhenrong Liu, Huijun Huang, Xueqin Zeng, Xiaozhi Ma
Glume-unclosing after anthesis is a widespread phenomenon in hybrid rice and also a maternal hereditary trait. The character of Glume-unclosing in rice male sterile lines also seriously influences germination rate and the commercial quality of hybrid rice seeds. We validated that the type of glume-unclosing after anthesis in the elite rice thermo-sensitive genic male sterile (TGMS) line RGD-7S was caused by high temperature. Transcriptomic sequencing of rice panicles was performed to explore the change of transcript profiles under four conditions: pre- and post-anthesis under high temperature (HRGD0 and HRGD1), and pre- and post-anthesis under low temperature (LRGD0 and LRGD1)...
2017: Frontiers in Plant Science
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