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https://www.readbyqxmd.com/read/28424421/the-soy-derived-peptide-lunasin-inhibits-invasive-potential-of-melanoma-initiating-cells
#1
Chris Shidal, Jun-Ichi Inaba, Kavitha Yaddanapudi, Keith R Davis
Lunasin is a 44 amino acid peptide with multiple functional domains including an aspartic acid tail, an RGD domain, and a chromatin-binding helical domain. We recently showed that Lunasin induced a phenotype switch of cancer initiating cells (CIC) out of the stem compartment by inducing melanocyte-associated differentiation markers while simultaneously reducing stem-cell-associated transcription factors. In the present study, we advance the hypothesis that Lunasin can reduce pools of melanoma cells with stem cell-like properties, and demonstrate that Lunasin treatment effectively inhibits the invasive potential of CICs in vitro as well as in vivo in a mouse experimental metastasis model...
March 10, 2017: Oncotarget
https://www.readbyqxmd.com/read/28423195/noninvasive-imaging-of-c-rgd-2-9r-as-a-potential-delivery-carrier-for-transfection-of-sirna-in-malignant-tumors
#2
Xue Qi Chen, Meng Liu, Rong Fu Wang, Ping Yan, Chun Li Zhang, Chao Ma, Qian Zhao, Lei Yin, Guang Yu Zhao, Feng Qin Guo
The purpose of our study was to develop and evaluate a novel integrin αv β3 -specific delivery carrier for transfection of siRNA in malignant tumors. We adopted arginine-glycine-aspartate (RGD) motif as a tissue target for specific recognition of integrin αν β3 . A chimaeric peptide was synthesized by adding nonamer arginine residues (9R) at the carboxy terminus of cyclic-RGD dimer, designated as c(RGD)2 -9R, to enable siRNA binding. To test the applicability of the delivery carrier in vivo, c(RGD)2 -9R was labeled with radionuclide of technetium-99 m...
April 18, 2017: Journal of Labelled Compounds & Radiopharmaceuticals
https://www.readbyqxmd.com/read/28416757/theranostic-imaging-of-liver-cancer-using-targeted-optical-mri-dual-modal-probes
#3
Qingshan Chen, Wenting Shang, Chaoting Zeng, Kun Wang, Xiaoyuan Liang, Chongwei Chi, Xiao Liang, Jian Yang, Chihua Fang, Jie Tian
The accurate preoperative detection and intraoperative navigation afforded by imaging techniques have had significant impact on the success of liver cancer surgeries. However, it is difficult to achieve satisfactory performance in both diagnosis and surgical treatment processes using any single modality imaging method. Here, we report the synthesis and characteristics of a novel dual-modality magnetic resonance imaging (MRI) and near-infrared fluorescence (NIRF) probe and verify its feasibility in nude mouse models with liver cancer...
February 23, 2017: Oncotarget
https://www.readbyqxmd.com/read/28414923/determining-the-true-selectivity-profile-of-%C3%AE-v-integrin-ligands-using-radioligand-binding-applying-an-old-solution-to-a-new-problem
#4
James E Rowedder, Steve B Ludbrook, Robert J Slack
The arginyl-glycinyl-aspartic acid (RGD) integrin subfamily contains five members that partner with the αv subunit: αvβ1, αvβ3, αvβ5, αvβ6, and αvβ8. Within the αv integrins, the epithelially restricted αvβ6 has been identified as playing a key role in the activation of transforming growth factor β that is hypothesized to be pivotal in the development of idiopathic pulmonary fibrosis (IPF). As part of a drug discovery program to identify a selective αvβ6 RGD mimetic for IPF, cell adhesion and radioligand binding assays were investigated to screen compounds to determine affinity and αv integrin selectivity...
April 1, 2017: SLAS Discovery
https://www.readbyqxmd.com/read/28412143/thermo-sensitive-assembly-of-the-biomaterial-rep-reduces-hematoma-volume-following-collagenase-induced-intracerebral-hemorrhage-in-rats
#5
Joohyun Park, Jong Youl Kim, Seong-Kyoon Choi, Jae Young Kim, Jae Hwan Kim, Won Bae Jeon, Jong Eun Lee
Intracerebral hemorrhage (ICH) frequently results in severe disabilities and high mortality. RGD-containing Elastin-Like Polypeptide (REP), a modified Elastin-Like Polypeptide (ELP), is a thermally responsive biopolymer. REP has high affinity for cells and is known to show non-immunotoxicity, -cytotoxicity, and -inflammatory responses. Here we found that administration of REP in the acute phase of the ICH rat model reduced the hematoma volume, decreased the number of activated microglia, attenuated the expression of von Willebrand Factor (vWF), and prevented the leakage of Immunoglobulin G (IgG) into the cerebral parenchyma without any occlusion of intact microvessels...
April 12, 2017: Nanomedicine: Nanotechnology, Biology, and Medicine
https://www.readbyqxmd.com/read/28407709/synergistic-antitumor-effect-of-ing4-pten-double-tumor-suppressors-mediated-by-adenovirus-modified-with-rgd-on-glioma
#6
Yaodong Zhao, Jiarong Wang, Jicheng Yang, Jingcheng Miao
BACKGROUND: Gene therapy is regarded as a new and promising therapeutic modality for cancers, and adenovirus is one of the most frequently used vectors. However, because of low or absent coxsackievirus and adenovirus receptor levels on the surface of many kinds of tumor cells, the efficiency of adenovirus infection of target tumor cells may be low. Meanwhile, gene therapy by a single vector carrying two or more anti-oncogenes can improve treatment effects and reduce side effects from vectors...
April 12, 2017: Journal of Neurosurgical Sciences
https://www.readbyqxmd.com/read/28405726/inter-heterogeneity-and-intra-heterogeneity-of-%C3%AE-v%C3%AE-3-in-non-small-cell-lung-cancer-and-small-cell-lung-cancer-patients-as-revealed-by-68-ga-rgd2-pet-imaging
#7
Fei Kang, Zhe Wang, Guoquan Li, Shengjun Wang, Daliang Liu, Mingru Zhang, Mingxuan Zhao, Weidong Yang, Jing Wang
PURPOSE: Integrin αvβ3 is the therapeutic target of the anti-angiogenic drug cilengitide. The objective of this study was to compare αvβ3 levels in non-small cell lung cancer (NSCLC) and small cell lung cancer (SCLC) patients, by using the positron emission tomography (PET) tracer (68)Ga-labeled dimerized-RGD ((68)Ga-RGD2). METHODS: Thirty-one patients with pathologically confirmed lung cancer were enrolled (21 were NSCLC and 10 were SCLC). PET/CT images were acquired using (68)Ga-RGD2...
April 12, 2017: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28403791/multimeric-system-of-rgd-grafted-pmma-nanoparticles-as-a-targeted-drug-delivery-system-for-paclitaxel
#8
Gibbens-Bandala Brenda Vianey, Ocampo-García Blanca Eli, Ferro-Flores Guillermina, Morales-Avila Enrique, Ancira-Cortez Alejandra, Jaimes-Aguirre Laura
BACKGROUND: Polymer-based nanoparticles as drug-delivery systems offer new therapeutic opportunities. Among them, ligand-mediated targeting, which increases selectivity and efficacy, allows controllable drug delivery. The aim of the this research was to prepare and characterize poly(methyl methacrylate) (PMMA) nanoparticles grafted with the -Arginine, Glycine, Aspartic Acid (RGD)- peptide sequence as a promising smart drug delivery system for Paclitaxel (PTX), directed at the sites of integrin receptor overexpression...
April 7, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28399159/effects-of-the-rgd-loop-and-c-terminus-of-rhodostomin-on-regulating-integrin-%C3%AE-iib%C3%AE-3-recognition
#9
Yao-Tsung Chang, Jia-Hau Shiu, Chun-Hao Huang, Yi-Chun Chen, Chiu-Yueh Chen, Yung-Sheng Chang, Woei-Jer Chuang
Rhodostomin (Rho) is a medium disintegrin containing a 48PRGDMP motif. We here showed that Rho proteins with P48A, M52W, and P53N mutations can selectively inhibit integrin αIIbβ3. To study the roles of the RGD loop and C-terminal region in disintegrins, we expressed Rho 48PRGDMP and 48ARGDWN mutants in Pichia pastoris containing 65P, 65PR, 65PRYH, 65PRNGLYG, and 65PRNPWNG C-terminal sequences. The effect of C-terminal region on their integrin binding affinities was αIIbβ3 > αvβ3 ≥ α5β1, and the 48ARGDWN-65PRNPWNG protein was the most selective integrin αIIbβ3 mutant...
2017: PloS One
https://www.readbyqxmd.com/read/28394627/rgd-mediated-delivery-of-small-molecule-drugs
#10
Sotirios Katsamakas, Theodora Chatzisideri, Savvas Thysiadis, Vasiliki Sarli
Conjugates of cytotoxic agents with RGD peptides (Arg-Gly-Asp) addressed to ανβ3, α5β1 and ανβ6 integrin receptors overexpressed by cancer cells, have recently gained attention as potential selective anticancer chemotherapeutics. In this review, the design and the development of RGD conjugates coupled to different small molecules including known cytotoxic drugs and natural products will be discussed.
April 10, 2017: Future Medicinal Chemistry
https://www.readbyqxmd.com/read/28393089/data-for-the-effects-of-rlj-rgd3-on-normal-tissues-of-rats-and-its-location-in-heya8-cells
#11
Yuanyuan Zheng, Jianmei Han, Yuping Wang, Qi Jiang, Yue Wang, Li Lv, Rong Xiao, Jihong Wang
Lj-RGD3 which contains three Arg-Gly-Asp (RGD) motifs was identified from the buccal glands of Lampetra japonica. In the present data article, acute toxicity of recombinant Lj-RGD3 (rLj-RGD3) was performed in Sprague Dawley (SD) rats. Tissue observation data of these SD rats treated with normal saline (NS) or rLj-RGD3 were shown. Furthermore, confocal microscope data were also shown to observe the location of FITC-labeled rLj-RGD3 in the ovarian cancer cells (HeyA8 cells). This paper contains data related to research concurrently published in "rLj-RGD3 induces apoptosis via the mitochondrial-dependent pathway and inhibits adhesion, migration and invasion of human HeyA8 cells via FAK pathway" (Q...
June 2017: Data in Brief
https://www.readbyqxmd.com/read/28393018/sonophore-labeled-rgd-a-targeted-contrast-agent-for-optoacoustic-imaging
#12
Katja Haedicke, Christian Brand, Murad Omar, Vasilis Ntziachristos, Thomas Reiner, Jan Grimm
Optoacoustic imaging is a rapidly expanding field for the diagnosis, characterization, and treatment evaluation of cancer. However, the availability of tumor specific exogenous contrast agents is still limited. Here, we report on a small targeted contrast agent for optoacoustic imaging using a black hole quencher(®) (BHQ) dye. The sonophore BHQ-1 exhibited strong, concentration-dependent, optoacoustic signals in phantoms, demonstrating its ideal suitability for optoacoustic imaging. After labeling BHQ-1 with cyclic RGD-peptide, BHQ-1-cRGD specifically bound to αvβ3-integrin expressing glioblastoma cell spheroids in vitro...
June 2017: Photoacoustics
https://www.readbyqxmd.com/read/28392965/mechanosignaling-activation-of-tgf%C3%AE-maintains-intervertebral-disc-homeostasis
#13
Qin Bian, Lei Ma, Amit Jain, Janet L Crane, Khaled Kebaish, Mei Wan, Zhengdong Zhang, X Edward Guo, Paul D Sponseller, Cheryle A Séguin, Lee H Riley, Yongjun Wang, Xu Cao
Intervertebral disc (IVD) degeneration is the leading cause of disability with no disease-modifying treatment. IVD degeneration is associated with instable mechanical loading in the spine, but little is known about how mechanical stress regulates nucleus notochordal (NC) cells to maintain IVD homeostasis. Here we report that mechanical stress can result in excessive integrin αvβ6-mediated activation of transforming growth factor beta (TGFβ), decreased NC cell vacuoles, and increased matrix proteoglycan production, and results in degenerative disc disease (DDD)...
2017: Bone Research
https://www.readbyqxmd.com/read/28390902/design-of-y-shaped-targeting-material-for-liposome-based-multifunctional-glioblastoma-targeted-drug-delivery
#14
Zakia Belhadj, Man Ying, Xie Cao, Xuefeng Hu, Changyou Zhan, Xiaoli Wei, Jie Gao, Xiaoyi Wang, Zhiqiang Yan, Weiyue Lu
Since the treatment of glioma in clinic has been hindered by the blood-brain barrier (BBB) and blood-brain tumor barrier (BBTB), multifunctional glioma-targeted drug delivery systems that can circumvent both barriers have received increasing scrutiny. Despite recent research efforts have been made to develop multifunctional glioma-targeted liposomes by decorating two or more ligands, few successful trials have been achieved due to the limitation of ligand density on the surface of liposomes. In this study, we designed a Y-shaped multifunctional targeting material c(RGDyK)-pHA-PEG-DSPE, in which cyclic RGD (c(RGDyK)) and p-hydroxybenzoic acid (pHA) were linked with a short spacer...
April 5, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/28385238/self-crosslinking-and-injectable-hyaluronic-acid-rgd-functionalized-pectin-hydrogel-for-cartilage-tissue-engineering
#15
Feng Chen, Yunzhou Ni, Bing Liu, Tongtong Zhou, Chunyang Yu, Yue Su, Xinyuan Zhu, Xiaowei Yu, Yongfeng Zhou
In the present study, we developed a biomimetic injectable hydrogel system based on hyaluronic acid-adipic dihydrazide and the oligopeptide G4RGDS-grafted oxidized pectin, in which their hydrazide and aldehyde-derivatives enable covalent hydrazone crosslinking of polysaccharides. The hydrazone crosslinking strategy is simple, while circumventing toxicity, making this injectable system feasible, minimally invasive and easily translatable for regenerative purposes. By varying their weight ratios, the physicochemical properties of the mechanically stable hydrogel system were easily adjustable...
June 15, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28381555/inclusion-of-an-arg-gly-asp-receptor-recognition-motif-into-the-capsid-protein-of-rabbit-hemorrhagic-disease-virus-enables-culture-of-the-virus-in-vitro
#16
Jie Zhu, Qiuhong Miao, Yonggui Tan, Huimin Guo, Teng Liu, Binbin Wang, Zongyan Chen, Chuanfeng Li, Guangqing Liu
Rabbit hemorrhagic disease virus (RHDV), an important member of the caliciviridae family, cannot be propagated in vitro, which has greatly impeded the progress of investigations into the mechanisms of pathogenesis, translation, and replication of this and related viruses. In this study, we have successfully bypassed this obstacle by constructing a mutant RHDV (mRHDV) by using a reverse genetics-technique. By changing two amino acids (305S→R, 307N→D), we produced a specific receptor recognition motif (Arg-Gly-Asp, called RGD) on the surface of the RHDV capsid protein...
April 5, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28378992/targeted-chemo-photodynamic-combination-platform-based-on-the-dox-prodrug-nanoparticles-for-enhanced-cancer-therapy
#17
Yumin Zhang, Fan Huang, Chunhua Ren, Lijun Yang, Jianfeng Liu, Zhen Cheng, Liping Chu, Jinjian Liu
Chemo-photodynamic combination therapy has been received widespread attention in cancer treatment due to its excellent characteristics, such as reducing the adverse side effects of chemo-drugs and improving the therapeutic effects for various cancers. In this study, RGD and DOX was conjugated to PEG by thiol-ene addition and Schiff's base reaction, respectively, to prepare the targeted and pH-sensitive antitumor prodrug nanoparticles (RGD-PEG-DOX NPs, RGD-NPs). Subsequently, the photosensitizer chlorin e6 (Ce6) was encapsulated into RGD-NPs, thus obtaining a simple and efficient chemo-photodynamic combination platform (RGD-PEG-DOX/Ce6 NPs, RGD-NPs/Ce6)...
April 10, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28377270/expression-and-functional-characterization-of-vitronectin-gene-from-japanese-flounder-paralichthys-olivaceus
#18
Shuo Li, Gaixiang Hao, Weijiao Peng, Xuyun Geng, Jinsheng Sun
Vitronectin (Vtn) is a multifunctional protein that plays significant roles in cell adhesion, migration, spreading and survival, and in the regulation of membrane attack complex formation and the terminal pathway of complement activation in innate immune response. However, the expression and immune significance of Vtn in fish remains largely unknown. In order to understand the involvement of Vtn in fish innate immune response, here we cloned and characterized a full-length Vtn ortholog cDNA, termed PoVtn, from Japanese flounder Paralichthys olivaceus...
April 1, 2017: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/28363829/integrin-signaling-potentiates-transforming-growth-factor-beta-1-tgf-%C3%AE-1-dependent-down-regulation-of-e-cadherin-expression-important-implications-for-epithelial-to-mesenchymal-transition-emt-in-renal-cell-carcinoma
#19
B Feldkoren, R Hutchinson, Y Rapaport, A Mahajan, V Margulis
Signal transduction through the transforming growth factor-beta 1 (TGF-β1) pathway affects epithelial to mesenchymal transition (EMT), partly by modulation of E-Cadherin expression. The concurrent impact of extracellular matrix driven regulation of integrin signaling on EMT has not been well characterized. We assessed the cumulative effect and molecular mechanisms of TGF-β1 and integrin signal transduction on E-Cadherin in a renal cell cancer (RCC) model. Stimulation of RCC cells with TGF-β1 demonstrated a three-fold increased expression of integrin αv...
March 28, 2017: Experimental Cell Research
https://www.readbyqxmd.com/read/28357093/triple-phase-99m-tc-3p-rgd2-imaging-of-peripheral-primitive-neuroectodermal-tumor-in-the-hip-muscle-group-with-bone-metastasis
#20
Jingjing Fu, Jinhua Song, Youcai Zhao, Feng Wang, Guoqiang Shao
Peripheral primitive neuroectodermal tumors (pPNETs) are a group of aggressive neoplasms that are most commonly encountered in pediatric patients and may be located in the abdomen, pelvis, thoracopulmonary region and, rarely, in the head and neck region. pPNETs in adults are extremely rare. The present study reports a case of pPNET located in the hip muscles with bone metastasis. The patient was a 44-year-old woman who complained of progressive pain and swelling with a mass near the left hip. Computed tomography (CT) and enhanced CT revealed a soft tissue mass lesion in the hip muscle group measuring 4...
February 2017: Molecular and Clinical Oncology
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