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https://www.readbyqxmd.com/read/29164650/market-share-and-costs-of-biologic-therapies-for-inflammatory-bowel-disease-in-the-usa
#1
H Yu, D MacIsaac, J J Wong, Z M Sellers, A A Wren, R Bensen, C Kin, K T Park
BACKGROUND: Real-world data quantifying the costs of increasing use of biologics in inflammatory bowel disease (IBD) are unknown. AIM: To determine the outpatient IBD drug utilization trends, relative market share, and costs in the USA during a 9-year period. METHODS: The Truven MarketScan(®) Database was analysed for patients with Crohn's disease (CD) and ulcerative colitis (UC) during 2007-2015. National drug codes were used to identify prescription drugs; Healthcare Common Procedure Coding System J-codes were used to capture biologic out-patient infusions...
November 22, 2017: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/29162577/cohort-profile-the-mayo-clinic-cohort-study-of-oophorectomy-and-aging-2-moa-2-in-olmsted-county-minnesota-usa
#2
Walter A Rocca, Liliana Gazzuola Rocca, Carin Y Smith, Brandon R Grossardt, Stephanie S Faubion, Lynne T Shuster, Elizabeth A Stewart, Michelle M Mielke, Kejal Kantarci, Virginia M Miller
PURPOSE: This cohort study was established to investigate the effects of unilateral and bilateral oophorectomy on the ageing processes in women. PARTICIPANTS: We used the records-linkage system of the Rochester Epidemiology Project (REP, http://www.rochesterproject.org) to identify 570 women who underwent unilateral oophorectomy and 1653 women who underwent bilateral oophorectomy in Olmsted County, Minnesota from 1988 through 2007 (20 years). Each woman was matched by age (±1 year) to a population-based referent woman who had not undergone any oophorectomy (570 referent women) or bilateral oophorectomy (1653 referent women)...
November 20, 2017: BMJ Open
https://www.readbyqxmd.com/read/29162500/the-emerging-role-of-immune-dysfunction-in-mitochondrial-diseases-as-a-paradigm-for-understanding-immunometabolism
#3
REVIEW
Senta M Kapnick, Susan E Pacheco, Peter J McGuire
Immunometabolism aims to define the role of intermediary metabolism in immune cell function, with bioenergetics and the mitochondria recently taking center stage. To date, the medical literature on mitochondria and immune function extols the virtues of mouse models in exploring this biologic intersection. While the laboratory mouse has become a standard for studying mammalian biology, this model comprises part of a comprehensive approach. Humans, with their broad array of inherited phenotypes, serve as a starting point for studying immunometabolism; specifically, patients with mitochondrial disease...
November 18, 2017: Metabolism: Clinical and Experimental
https://www.readbyqxmd.com/read/29162432/renal-damage-in-the-metabolic-syndrome-metsx-disorders-implicated
#4
REVIEW
Trujillo Joyce, Chirino Yolanda Irasema, Martínez-Tagüeña Natalia, Pedraza-Chaverri Jose
The prevalence of metabolic syndrome is increasing worldwide and has become a risk factor for the development of chronic kidney disease. The complex linkage between metabolic syndrome and chronic kidney disease is under research and the factors involved beyond the biological pathogenesis include demographic, sociological and psychological factors that are related to the metabolic syndrome prevalence. The social context of disease causation is as relevant to today's clinical scientist and practitioner as biomarker-directed risk stratification and therapy...
November 18, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/29162092/applying-systems-biology-to-biomedical-research-and-health-care-a-pr%C3%A3-cising-definition-of-systems-medicine
#5
Sebastian Schleidgen, Sandra Fernau, Henrike Fleischer, Christoph Schickhardt, Ann-Kristin Oßa, Eva C Winkler
BACKGROUND: Systems medicine has become a key word in biomedical research. Although it is often referred to as P4-(predictive, preventive, personalized and participatory)-medicine, it still lacks a clear definition and is open to interpretation. This conceptual lack of clarity complicates the scientific and public discourse on chances, risks and limits of Systems Medicine and may lead to unfounded hopes. Against this background, our goal was to develop a sufficiently precise and widely acceptable definition of Systems Medicine...
November 21, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/29162047/treatment-recommendations-within-the-leeway-of-clinical-guidelines-a-qualitative-interview-study-on-oncologists-clinical-deliberation
#6
I Otte, S Salloch, A Reinacher-Schick, J Vollmann
BACKGROUND: Recommending the optimal treatment for an individual patient requires a well-balanced consideration of various medical, social and ethical factors. The interplay of these factors, interpretation of the patient's situation and understanding of the existing clinical guidelines can lead to divergent therapy recommendations, depending on the attending physician. Gaining a better understanding of the individual process of medical decision-making and the differences occurring will support the delivery of optimal individualized care within the clinical setting...
November 21, 2017: BMC Cancer
https://www.readbyqxmd.com/read/29161276/association-between-diabetes-mellitus-and-active-tuberculosis-a-systematic-review-and-meta-analysis
#7
Rami H Al-Rifai, Fiona Pearson, Julia A Critchley, Laith J Abu-Raddad
The burgeoning epidemic of diabetes mellitus (DM) is one of the major global health challenges. We systematically reviewed the published literature to provide a summary estimate of the association between DM and active tuberculosis (TB). We searched Medline and EMBASE databases for studies reporting adjusted estimates on the TB-DM association published before December 22, 2015, with no restrictions on region and language. In the meta-analysis, adjusted estimates were pooled using a DerSimonian-Laird random-effects model, according to study design...
2017: PloS One
https://www.readbyqxmd.com/read/29160831/a-novel-detection-method-of-human-serum-albumin-based-on-the-poly-thymine-templated-copper-nanoparticles
#8
Mingjian Chen, Xinying Xiang, Kefeng Wu, Hailun He, Hanchun Chen, Changbei Ma
In this work, we developed a facile fluorescence method for quantitative detection of human serum albumin (HSA) based on the inhibition of poly(thymine) (poly T)-templated copper nanoparticles (CuNPs) in the presence of HSA. Under normal circumstances, poly T-templated CuNPs can display strong fluorescence with excitation/emission peaks at 340/610 nm. However, in the presence of HSA, it will absorb cupric ion, which will prevent the formation of CuNPs. As a result, the fluorescence intensity will become obviously lower in the presence of HSA...
November 21, 2017: Sensors
https://www.readbyqxmd.com/read/29160756/recent-developments-on-treatment-strategies-and-the-prognosis-of-dermatomyositis-a-review
#9
Verena Isak, Joseph L Jorizzo
Dermatomyositis is an autoimmune disease affecting both skin and muscle. Steroids are the first line treatment. However, no consensus regarding dosing, length of treatment, tapering speed, or when to add which immunosuppressant in case of steroid resistance, has been reached, as randomized-controlled trials are scarce. Especially data on long-term treatment is lacking in order to decide on the most effective treatment for long-term remission. Empiric evidence suggests that with an initially aggressive treatment with oral steroids followed by a slow taper, during which disease activity is adequately controlled, patients can be off therapy within typically 24 to 48 months, and remain disease-free without medication for over 20 years...
November 21, 2017: Journal of Dermatological Treatment
https://www.readbyqxmd.com/read/29160301/new-insights-into-the-pharmacogenomics-of-antidepressant-response-from-the-gendep-and-star-d-studies-rare-variant-analysis-and-high-density-imputation
#10
C Fabbri, K E Tansey, R H Perlis, J Hauser, N Henigsberg, W Maier, O Mors, A Placentino, M Rietschel, D Souery, G Breen, C Curtis, L Sang-Hyuk, S Newhouse, H Patel, M Guipponi, N Perroud, G Bondolfi, M O'Donovan, G Lewis, J M Biernacka, R M Weinshilboum, A Farmer, K J Aitchison, I Craig, P McGuffin, R Uher, C M Lewis
Genome-wide association studies have generally failed to identify polymorphisms associated with antidepressant response. Possible reasons include limited coverage of genetic variants that this study tried to address by exome genotyping and dense imputation. A meta-analysis of Genome-Based Therapeutic Drugs for Depression (GENDEP) and Sequenced Treatment Alternatives to Relieve Depression (STAR*D) studies was performed at the single-nucleotide polymorphism (SNP), gene and pathway levels. Coverage of genetic variants was increased compared with previous studies by adding exome genotypes to previously available genome-wide data and using the Haplotype Reference Consortium panel for imputation...
November 21, 2017: Pharmacogenomics Journal
https://www.readbyqxmd.com/read/29160046/sutureless-aortic-valve-and-tavi-pros-and-cons
#11
Thierry Folliguet
Aortic valve replacement with biological heart valves remains the gold standard for treating operable older patients with symptomatic aortic stenosis. In the last years trans aortic valve implantation (TAVI) has been shown to be superior to medical treatment in high risks patients with severe aortic stenosis. The transfemoral TAVI route has been also found in randomized controlled trials to be as good if not superior to standard AVR at 5 years in high risk patients. In intermediate risks patients TAVI was found in randomized controlled trials as a noninferior alternative to surgery, with a different pattern of adverse events associated with each procedure...
November 20, 2017: Minerva Cardioangiologica
https://www.readbyqxmd.com/read/29159257/development-and-analytical-performance-of-a-new-architect-automated-dipeptidyl-peptidase-4-immunoassay
#12
Philip M Hemken, Nicolette M Jeanblanc, Tracey Rae, Susan E Brophy, Maria J Datwyler, Ying Xu, T Scott Manetz, Inna Vainshtein, Meina Liang, Xiaodong Xiao, Partha S Chowdhury, Chien-Ying Chang, Katie Streicher, Lydia Greenlees, Koustubh Ranade, Gerard J Davis
Background: Dipeptidyl peptidase-4 (DPP-4) may be a suitable biomarker to identify people with severe asthma who have greater activation of the interleukin-13 (IL-13) pathway and may therefore benefit from IL-13-targeted treatments. We report the analytical performance of an Investigational Use Only immunoassay and provide data on the biological range of DPP-4 concentrations. Methods: We assessed assay performance, utilising analyses of precision, linearity and sensitivity; interference from common endogenous assay interferents, and from asthma and anti-diabetic medications, were also assessed...
December 2017: Pract Lab Med
https://www.readbyqxmd.com/read/29158995/the-role-of-biomaterials-in-the-treatment-of-meniscal-tears
#13
Crystal O Kean, Robert J Brown, James Chapman
Extensive investigations over the recent decades have established the anatomical, biomechanical and functional importance of the meniscus in the knee joint. As a functioning part of the joint, it serves to prevent the deterioration of articular cartilage and subsequent osteoarthritis. To this end, meniscus repair and regeneration is of particular interest from the biomaterial, bioengineering and orthopaedic research community. Even though meniscal research is previously of a considerable volume, the research community with evolving material science, biology and medical advances are all pushing toward emerging novel solutions and approaches to the successful treatment of meniscal difficulties...
2017: PeerJ
https://www.readbyqxmd.com/read/29158266/stilbenoid-prenyltransferases-define-key-steps-in-the-diversification-of-peanut-phytoalexins
#14
Tianhong Yang, Lingling Fang, Sheri Sanders, Srinivas Jayanthi, Gayathri Rajan, Ram Podicheti, Suresh Kumar Thallapuranam, Keithanne Mockaitis, Fabricio Medina-Bolivar
Defense responses of peanut (Arachis hypogaea) to biotic and abiotic stresses include the synthesis of prenylated stilbenoids. Members of this compound class show several protective activities in human disease studies, and the list of potential therapeutic targets continues to expand. Despite their medical and biological importance, the biosynthetic pathways of prenylated stilbenoids remain to be elucidated, and the genes encoding stilbenoid-specific prenyltransferases have yet to be identified in any plant species...
November 20, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29157144/personal-exposure-of-dairy-workers-to-dust-endotoxin-muramic-acid-ergosterol-and-ammonia-on-large-scale-dairies-in-the-high-plains-western-united-states
#15
Margaret E Davidson, Joshua Schaeffer, Maggie L Clark, Sheryl Magzamen, Elizabeth J Brooks, Thomas J Keefe, Mary Bradford, Noa Roman-Muniz, John Mehaffy, Gregory Dooley, Jill A Poole, Frank M Mitloehner, Sue Reed, Marc B Schenker, Stephen J Reynolds
Dairy workers experience a high degree of bioaerosol exposure, composed of an array of biological and chemical constituents, which have been tied to adverse health effects. A better understanding of the variation in the magnitude and composition of exposures by task is needed to inform worker protection strategies. To characterize the levels and types of exposures, 115 dairy workers grouped into three task categories on nine farms in the high plains western United States underwent personal monitoring for inhalable dust, endotoxin, 3-hydroxy fatty acids (3-OHFA), muramic acid, ergosterol, and ammonia over one work shift...
November 20, 2017: Journal of Occupational and Environmental Hygiene
https://www.readbyqxmd.com/read/29155848/an-electronic-health-record-based-model-predicts-statin-adherence-ldl-cholesterol-and-cardiovascular-disease-in-the-united-states-military-health-system
#16
Joseph E Lucas, Taylor C Bazemore, Celan Alo, Patrick B Monahan, Deepak Voora
HMG-CoA reductase inhibitors (or "statins") are important and commonly used medications to lower cholesterol and prevent cardiovascular disease. Nearly half of patients stop taking statin medications one year after they are prescribed leading to higher cholesterol, increased cardiovascular risk, and costs due to excess hospitalizations. Identifying which patients are at highest risk for not adhering to long-term statin therapy is an important step towards individualizing interventions to improve adherence. Electronic health records (EHR) are an increasingly common source of data that are challenging to analyze but have potential for generating more accurate predictions of disease risk...
2017: PloS One
https://www.readbyqxmd.com/read/29154846/effect-of-piper-betle-on-giardia-intestinalis-infection-in-vivo
#17
Radka Pecková, Karel Doležal, Bohumil Sak, Dana Květoňová, Martin Kváč, Wisnu Nurcahyo, Ivona Foitová
Piper betle has been used as a medicinal plant in traditional medical systems throughout South and South East Asia. Experimental studies have revealed its wide and diverse biological and pharmacological effects. In this study, antigiardial activity of Piper betle was tested using experimental infections of Giardia intestinalis, the most common cause of protozoal diarrhoea worldwide, in Mongolian gerbils. Plants were extracted in water, methanol and methanol:tetrahydrofuran. Gerbils were treated for ten days intragastrically twice a day, with the dose of 40 mg of the extract per 100 g of body weight...
November 14, 2017: Experimental Parasitology
https://www.readbyqxmd.com/read/29154040/multifunctional-protein-microparticles-for-medical-applications
#18
Hironori Yamazoe
Micro- and nano-scale intelligent devices can revolutionize the medical field. Although proteins are promising materials for creating biocompatible miniature medical devices with biological functions, construction of complicated solid-state architectures, using inherently vulnerable proteins, remains challenging. Here, I present a sophisticated strategy for constructing a multifunctional microparticle for medical applications using multiple proteins; this strategy achieved the retention of function, increased stability, and orientation control of the proteins in the fabricated particle...
October 31, 2017: Biomaterials
https://www.readbyqxmd.com/read/29153870/factors-associated-with-use-of-disease-modifying-agents-for-rheumatoid-arthritis-in-the-national-hospital-and-ambulatory-medical-care-survey
#19
Priyanka Gaitonde, Laura M Bozzi, Fadia T Shaya
OBJECTIVE: We examined the treatment patterns among adults with rheumatoid arthritis (RA) and identified factors influencing access to traditional and biological disease modifying antirheumatic drugs (DMARDs). METHODS: We analyzed visits recorded in the National Ambulatory Medical Care Survey from 2005 to 2014 with a RA diagnosis. The primary outcome was DMARD use (traditional and/or biological). We included prescriptions of all RA-related treatments such as traditional and biological DMARDs, glucocorticoids, gold preparations, immunosuppressants, and non-steroidal anti-inflammatory drugs...
October 18, 2017: Seminars in Arthritis and Rheumatism
https://www.readbyqxmd.com/read/29153862/tumor-necrosis-factor-alpha-in-sleep-regulation
#20
REVIEW
Matthew D Rockstrom, Liangyu Chen, Ping Taishi, Joseph T Nguyen, Cody M Gibbons, Sigrid C Veasey, James M Krueger
This review details tumor necrosis factor alpha (TNF) biology and its role in sleep, and describes how TNF medications influence sleep/wake activity. Substantial evidence from healthy young animals indicates acute enhancement or inhibition of endogenous brain TNF respectively promotes and inhibits sleep. In contrast, the role of TNF in sleep in most human studies involves pathological conditions associated with chronic elevations of systemic TNF and disrupted sleep. Normalization of TNF levels in such patients improves sleep...
November 16, 2017: Sleep Medicine Reviews
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