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https://www.readbyqxmd.com/read/28945052/negative-influence-of-preoperative-tinnitus-on-hearing-preservation-in-vestibular-schwannoma-surgery
#1
Luciano Mastronardi, Guglielmo Cacciotti, Raffaellino Roperto, Ettore DI Scipio
BACKGROUNDS: Goals of vestibular schwannoma (VS) microsurgery are: maximal resection, facial nerve (FN) preservation and, in selected cases, hearing preservation (HP). Postoperative HP rates are related to clinical and radiographic factors: size of tumor, preoperative hearing, hypertension, diabetes, and presence or absence of preoperative tinnitus. In this retrospective review we evaluated the influence of preoperative tinnitus on HP after VS surgery in patients with preoperative socially useful hearing (SUH)...
September 22, 2017: Journal of Neurosurgical Sciences
https://www.readbyqxmd.com/read/28945021/-progress-of-new-antidepressant-drugs-development
#2
REVIEW
Xiao Zhang, Jun-Sheng Tian, Huan Liu, Xue-Mei Qin
Depression becomes more and more serious and has been greatly do harm to human's physical and mental health. WHO predicts that depression will become the second leading cause of abnormal death and disability by 2020. There is still the drug treatment as the first-line antidepressive therapy, but the effect of listed antidepressant drugs is not ideal. Therefore, discovery of new antidepressant drug of sunique, higher curative effect, less adverse reaction is the pursuit of pharmaceutical. The traditional Chinese medicine (TCM) of anti-depression and natural antidepressant in currently listed, drug development and drug discovery phase are summarized in this paper, aiming to provide reference for new antidepressant drug research...
January 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/28945011/prediction-of-drug-drug-interaction-between-tacrolimus-and-principal-ingredients-of-wuzhi-capsule-in-chinese-healthy-volunteers-using-physiologically-based-pharmacokinetic-modelling
#3
Hongyan Zhang, Fengjiao Bu, Lei Li, Zheng Jiao, Guo Ma, Weimin Cai, Xiaomei Zhuang, Hai-Shu Lin, Jae-Gook Shin, Xiaoqiang Xiang
Schisantherin A and schisandrin A, the most abundant active ingredients of Wuzhi capsule, are known to inhibit tacrolimus metabolism by inhibiting CYP3A4/5. We aimed to predict the contribution of schisantherin A and schisandrin A to drug-drug interaction (DDI) between Wuzhi capsule and tacrolimus using physiologically-based pharmacokinetic (PBPK) modelling. Firstly, the inhibition mechanism of schisantherin A and schisandrin A on CYP3A4/5 were investigated. Thereafter, PBPK models of schisantherin A, schisandrin A and tacrolimus were established...
September 25, 2017: Basic & Clinical Pharmacology & Toxicology
https://www.readbyqxmd.com/read/28945001/organ-on-a-chip-technology-for-reproducing-multiorgan-physiology
#4
REVIEW
Seung Hwan Lee, Jong Hwan Sung
In the drug development process, the accurate prediction of drug efficacy and toxicity is important in order to reduce the cost, labor, and effort involved. For this purpose, conventional 2D cell culture models are used in the early phase of drug development. However, the differences between the in vitro and the in vivo systems have caused the failure of drugs in the later phase of the drug-development process. Therefore, there is a need for a novel in vitro model system that can provide accurate information for evaluating the drug efficacy and toxicity through a closer recapitulation of the in vivo system...
September 25, 2017: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/28944994/influence-of-cyanobacteria-mixotrophic-flagellates-and-virioplankton-size-fraction-on-transcription-of-microcystin-synthesis-genes-in-the-toxic-cyanobacterium-microcystis-aeruginosa
#5
Pia I Scherer, Carolin Absmeier, Maria Urban, Uta Raeder, Juergen Geist, Katrin Zwirglmaier
Toxic cyanobacteria such as Microcystis aeruginosa are a worldwide concern in freshwater reservoirs. Problems associated with their mass occurrence are predicted to increase in the future due to global warming. The hepatotoxic secondary metabolite microcystin is of particular concern in this context. This study aimed to determine whether co-occurring microorganisms influence the expression of microcystin biosynthesis genes. To this end, we performed cocultivation experiments and measured mcyB and mcyD transcripts in M...
September 25, 2017: MicrobiologyOpen
https://www.readbyqxmd.com/read/28944969/family-and-couple-variables-regarding-adherence-in-type-2-diabetes-patients-in-the-initial-stages-of-the-disease
#6
M Graça Pereira, Susana Pedras, Gabriela Ferreira, José C Machado
This study analyzed which family and couple variables predicted adherence to standard care treatment, in patients recently diagnosed with type 2 diabetes. The sample comprised 224 dyads assessed during the first year of diagnosis (T1) and 4 months later (T2). The results showed that family stress, dyadic adjustment, family coping, and positive support assessed by patients at T1 predicted medication adherence and glucose monitoring at T2. Positive support and dyadic adjustment, assessed by partners at T1, predicted patients' adherence to glucose monitoring and diet at T2...
September 25, 2017: Journal of Marital and Family Therapy
https://www.readbyqxmd.com/read/28944935/models-to-predict-readmission-rates-trying-to-sand-the-wings-of-the-boomerang
#7
Thomas Münzer
No abstract text is available yet for this article.
September 25, 2017: Swiss Medical Weekly
https://www.readbyqxmd.com/read/28944929/oncogenic-mir%C3%A2-132-sustains-proliferation-and-self%C3%A2-renewal-potential-by-inhibition-of-polypyrimidine-tract%C3%A2-binding-protein-2-in-glioblastoma-cells
#8
Silong Lou, Jia Ji, Xin Cheng, Jian Ruan, Rong Li, Zhengjun Guo
Glioblastoma multiforme (GBM) is the leading type of brain tumor, exhibiting unlimited proliferation and invasion potential. The present study indicated that a high expression level of miR‑132 was detected in the neural subtype of GBM and predicted an unfavorable prognosis for patients from The Cancer Genome Atlas cohort (n=526). Cox hazard regression analysis demonstrated miR‑132 as an independent prognostic indicator for GBM patients. Further in vitro experiments indicated that miR‑132 promoted the proliferation and sphere formation of U87 cells...
September 21, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28944926/upregulation-of-long-noncoding-rna-ap003419-16-predicts-high-risk-of-aging%C3%A2-associated-idiopathic-pulmonary-fibrosis
#9
Xiaoyan Hao, Yufeng Du, Li Qian, Dan Li, Xuejun Liu
Long noncoding RNAs (lncRNAs) are able to regulate adjacent genes and thus participate in the incidence in the present study has identified lncRNA AP003419.16, adjacent to the protein‑coding gene ribosomal protein S6 kinase B‑2 (RPS6KB2). RPS6KB2 is believed to be involved in the process of aging and idiopathic pulmonary fibrosis (IPF), due to its activation by growth factors and regulation by the protein kinase mTOR signaling pathway. The results of the present study indicated that the expression of AP003419...
September 25, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28944917/application-of-a-co%C3%A2-expression-network-for-the-analysis-of-aggressive-and-non%C3%A2-aggressive-breast-cancer-cell-lines-to-predict-the-clinical-outcome-of-patients
#10
Ling Guo, Kun Zhang, Zhitong Bing
Breast cancer metastasis is a demanding problem in clinical treatment of patients with breast cancer. It is necessary to examine the mechanisms of metastasis for developing therapies. Classification of the aggressiveness of breast cancer is an important issue in biological study and for clinical decisions. Although aggressive and non‑aggressive breast cancer cells can be easily distinguished among different cell lines, it is very difficult to distinguish in clinical practice. The aim of the current study was to use the gene expression analysis from breast cancer cell lines to predict clinical outcomes of patients with breast cancer...
September 25, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28944900/circulating-mirna%C3%A2-21-is-a-promising-biomarker-for-heart-failure
#11
Jianghua Zhang, Qiang Xing, Xianhui Zhou, Jinxin Li, Yaodong Li, Lin Zhang, Qina Zhou, Baopeng Tang
microRNA 21 (miRNA‑21) promotes the development of cardiac fibrosis, hypertrophy and heart failure. However, whether it can be used as a biomarker for the diagnosis and prognosis of heart failure remains unclear. The current study assessed circulating miRNA‑21 as a viable indicator for diagnosis and prognosis of heart failure. The levels of miRNA‑21 and brain natriuretic peptide were measured in serum obtained from the peripheral vein (miRNA‑21‑PV) and coronary sinus (miRNA‑21‑CS) of 80 patients with heart failure and 40 control individuals via reverse transcription‑quantitative polymerase chain reaction and ELISA, respectively...
September 21, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28944897/high-expression-of-endoglin-in-primary-breast-cancer-may-predict-response-to-neoadjuvant-chemotherapy
#12
Kun-Ming Rau, Yu-Li Su, Shan-Hsuan Li, Meng-Che Hsieh, Shis-Chung Wu, Fong-Fu Chou, Tai-Jan Chiu, Yen-Hao Chen, Chien-Ting Liu
Neoadjuvant chemotherapy (NAC) is a widely‑used treatment for breast cancer, as it may render unresecta-ble breast tumors to become resectable. In addition, NAC provides the unique opportunity to assess response to treatments within months rather than years of follow‑up. However, predictive markers of tumor response to NAC are lacking. Therefore, the present study aimed to investigate the expression of endoglin, a marker of angiogenesis, and its association with pathologic responses to NAC. Samples from 34 breast cancer patients were obtained prior to and following NAC treatment...
September 20, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28944868/microrna%C3%A2-198-contributes-to-lupus-nephritis-progression-by-inhibition-of-phosphatase-and-tensin-homology-deleted-on-chromosome-ten-expression
#13
Danyu Cui, Dingji Zhu, Hao Ren, Jingli Lin, Weinan Lai, Qin Huang, Jinjun Zhao, Min Yang
A number of short noncoding microRNAs (miRs) have been demonstrated to be highly expressed in many kidney diseases such as renal cancer and lupus nephritis (LN); however, these results have not been extensively investigated. The aim of the present study was to investigate the expression and function of miR‑198 in LN based on the previous studies. miR‑198 expression level in systemic lupus erythematosus (SLE) patients was determined to determine its clinicopathological significance and effect on glomerular cell proliferation...
September 19, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28944858/decreased-expression-of-hsa%C3%A2-mir%C3%A2-372-predicts-poor-prognosis-in-patients-with-gallbladder-cancer-by-affecting-chloride-intracellular-channel-1
#14
Ning Zhou, Wei Cheng, Chuang Peng, Yi Liu, Bo Jiang
It has been reported that hsa‑microRNA (miRNA/miR)‑372 functions as a tumor suppressor or oncogene in various digestive system tumors, however, its roles in gallbladder cancer (GBC) are yet to be established. The present study aimed to determine the expression and clinical relevance of hsa‑miR‑372 in GBC. The expression of hsa‑miR‑372 in 80 pairs of human GBC tissues and adjacent normal gallbladder tissues was measured by reverse transcription‑quantitative polymerase chain reaction. Subsequently, the associations between hsa‑miR‑372 expression levels and the clinicopathological characteristics of patients with GBC were determined using χ2 test...
September 19, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28944857/a-novel-fbn1-mutation-causes-autosomal-dominant-marfan-syndrome
#15
Ying Xiao, Xiaoqi Liu, Xiaoxin Guo, Liping Liu, Linxin Jiang, Qi Wang, Bo Gong
Marfan syndrome (MFS) is an inherited and systemic disorder. It has been reported that mutations in the fibrillin‑1 gene (FBN1) account for ~90% of autosomal dominant cases of MFS. This study was conducted to screen mutations of FBN1 in a Chinese family with autosomal dominant MFS; four individuals including two patients with MFS were recruited. The family members underwent complete physical, cardiovascular and ophthalmologic examinations. Genomic DNA samples were collected from the family along with 383 unrelated healthy subjects...
September 20, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28944822/investigation-of-crucial-genes-and-micrornas-in-conventional-osteosarcoma-using-gene-expression-profiling-analysis
#16
Chuangang Peng, Qi Yang, Bo Wei, Baoming Yuan, Yong Liu, Yuxiang Li, Dawer Gu, Guochao Yin, Bo Wang, Dehui Xu, Xuebing Zhang, Daliang Kong
The present study aimed to screen potential genes associated with conventional osteosarcoma (OS) and obtain further information on the pathogenesis of this disease. The microarray dataset GSE14359 was downloaded from the Gene Expression Omnibus. A total of 10 conventional OS samples and two non‑neoplastic primary osteoblast samples in the dataset were selected to identify the differentially expressed genes (DEGs) using the Linear Models for Microarray Data package. The potential functions of the DEGs were predicted using Gene Ontology (GO) and pathway enrichment analyses...
September 18, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28944815/chemical-mediated-elasto-capillarity-of-elastic-sheets
#17
Jianlin Liu, Yulong Gong, Gaofeng Cao
Capillary forces can cause outstanding deformation of slender structures, and this behavior holds great potential in a plethora of areas. In this study, we propose a facile strategy to mediate the deformation of elastic structures via chemicals, which is named chemo-elasto-capillarity. The experiment shows that the added surfactant can significantly change the interfacial energy of the system, and then modulate the configuration of the adhered structures. The wetted length and deflection of each sheet can be predicted using the large and infinitesimal deformation theory of beams, and these theoretical values are in excellent agreement with the experimental results...
September 25, 2017: Soft Matter
https://www.readbyqxmd.com/read/28944810/microfluidic-step-emulsification-in-axisymmetric-geometry
#18
I Chakraborty, J Ricouvier, P Yazhgur, P Tabeling, A M Leshansky
Biphasic step-emulsification (Z. Li et al., Lab Chip, 2015, 15, 1023) is a promising microfluidic technique for high-throughput production of μm and sub-μm highly monodisperse droplets. The step-emulsifier consists of a shallow (Hele-Shaw) microchannel operating with two co-flowing immiscible liquids and an abrupt expansion (i.e., step) to a deep and wide reservoir. Under certain conditions the confined stream of the disperse phase, engulfed by the co-flowing continuous phase, breaks into small highly monodisperse droplets at the step...
September 25, 2017: Lab on a Chip
https://www.readbyqxmd.com/read/28944719/prognostic-value-of-sst2-and-nt-probnp-at-admission-in-heart-failure-with-preserved-mid-ranged-and-reduced-ejection-fraction
#19
Anan Huang, Xin Qi, Wenguang Hou, Yanfang Qi, Na Zhao, Keqaing Liu
OBJECTIVE: The aim of this study was to compare sST2 at admission with N-terminal pro B-type natriuretic peptide (NT-proBNP) in prognostic accuracy among different types of heart failure (HF) and clarifying the enhanced prognostic value in patients with HF by the combination of the two biomarkers. METHODS AND RESULTS: A total of 164 consecutive patients admitted to our institution for HF were divided into three groups of HF with reduced ejection fraction (HFrEF), HF with mid-range ejection fraction (HFmrEF) and HF with preserved ejection fraction (HFpEF)...
September 25, 2017: Acta Cardiologica
https://www.readbyqxmd.com/read/28944716/breast-cancer-screening-among-women-in-namibia-explaining-the-effect-of-health-insurance-coverage-and-access-to-information-on-screening-behaviours
#20
Joseph Kangmennaang, Paul Mkandawire, Isaac Luginaah
OBJECTIVES: Breast cancer contributes substantially to morbidity and mortality in Namibia as is the case in most countries in Sub-Saharan Africa (SSA). However, there is a dearth of nationally representative studies that examine the odds of screening for breast cancer in Namibia and SSA at large. This paper aims to fill this gap by examining the determinants of breast cancer screening guided by the Health Belief Model. METHODS: We applied hierarchical binary logit regression models to explore the determinants of breast cancer screening using the 2013 Namibia Demography and Health Survey (NDHS)...
September 1, 2017: Global Health Promotion
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