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https://www.readbyqxmd.com/read/28539035/the-performance-of-serum-biomarkers-for-predicting-fibrosis-in-patients-with-chronic-viral-hepatitis
#1
Chang Seok Bang, Ha Yan Kang, Gyu Ho Choi, Suk Bae Kim, Wonae Lee, Il Han Song
Background/Aims: The invasiveness of a liver biopsy and its inconsistent results have prompted efforts to develop noninvasive tools to evaluate the severity of chronic hepatitis. This study was intended to assess the performance of serum biomarkers for predicting liver fibrosis in patients with chronic viral hepatitis. Methods: A total of 302 patients with chronic hepatitis B or C, who had undergone liver biopsy, were retrospectively enrolled. We investigated the diagnostic accuracy of several clinical factors for predicting advanced fibrosis (F≥3)...
May 25, 2017: Korean Journal of Gastroenterology, Taehan Sohwagi Hakhoe Chi
https://www.readbyqxmd.com/read/28538996/the-relationship-between-surface-curvature-and-abdominal-aortic-aneurysm-wall-stress
#2
Sergio Ruiz de Galarreta, Aitor Cazon, Raúl Antón, Ender A Finol
The maximum diameter criterion is the most important factor when predicting risk of rupture of abdominal aortic aneurysms (AAA). An elevated wall stress has also been linked to a high risk of aneurysm rupture, yet is an uncommon clinical practice to compute AAA wall stress. The purpose of this study is to assess whether other characteristics of the AAA geometry are statistically correlated with wall stress. Using in-house segmentation and meshing algorithms, thirty patient-specific AAA models were generated for finite element analysis...
May 24, 2017: Journal of Biomechanical Engineering
https://www.readbyqxmd.com/read/28538994/predictive-feature-remapping-before-saccadic-eye-movements
#3
Dongjun He, Ce Mo, Fang Fang
Saccadic eye movements cause rapid and dramatic displacements of the retinal image of the visual world, yet our conscious perception of the world remains stable and continuous. A popular explanation for this remarkable ability of our visual system to compensate for the displacements is the predictive feature remapping theory. The theory proposes that, before saccades, the representation of a visual stimulus can be predictively transferred from neurons that initially encode the stimulus to neurons whose receptive fields will encompass the stimulus location after the saccade...
May 1, 2017: Journal of Vision
https://www.readbyqxmd.com/read/28538950/association-of-adjuvant-chemotherapy-with-survival-in-patients-with-stage-ii-or-iii-gastric-cancer
#4
Yuming Jiang, Tuanjie Li, Xiaoling Liang, Yanfeng Hu, Lei Huang, Zhenchen Liao, Liying Zhao, Zhen Han, Shuguang Zhu, Menglan Wang, Yangwei Xu, Xiaolong Qi, Hao Liu, Yang Yang, Jiang Yu, Wei Liu, Shirong Cai, Guoxin Li
Importance: The current staging system of gastric cancer is not adequate for defining a prognosis and predicting the patients most likely to benefit from chemotherapy. Objective: To construct a survival prediction model based on specific tumor and patient characteristics that enables individualized predictions of the net survival benefit of adjuvant chemotherapy for patients with stage II or stage III gastric cancer. Design, Setting, and Participants: In this multicenter retrospective analysis, a survival prediction model was constructed using data from a training cohort of 746 patients with stage II or stage III gastric cancer who satisfied the study's inclusion criteria and underwent surgery between January 1, 2004, and December 31, 2012, at Nanfang Hospital in Guangzhou, China...
May 24, 2017: JAMA Surgery
https://www.readbyqxmd.com/read/28538837/microrna-455-suppresses-the-oncogenic-function-of-hdac2-in-human-colorectal-cancer
#5
Q D Mao, W Zhang, K Zhao, B Cao, H Yuan, L Z Wei, M Q Song, X S Liu
Colorectal cancer (CRC) is the fourth leading cause of cancer-induced mortality. Histone deacetylase 2 (HDAC2) is involved in prognosis and therapy of CRC. This study aimed to explore novel therapeutic targets for CRC. The alteration of HDAC2 expression in CRC tissues was estimated by qRT-PCR. After lentivirus transfection, HDAC2 knockdown was confirmed by western blot analysis. The effect of HDAC2 knockdown on cell proliferation was then assessed by 3-(4,5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide (MTT) assay...
May 18, 2017: Brazilian Journal of Medical and Biological Research, Revista Brasileira de Pesquisas Médicas e Biológicas
https://www.readbyqxmd.com/read/28538812/climatically-mediated-landcover-change-impacts-on-brazilian-territory
#6
Marina Zanin, Geiziane Tessarolo, Nathália Machado, Ana Luisa M Albernaz
In the face of climate change threats, governments are drawing attention to policies for mitigating its effects on biodiversity. However, the lack of distribution data makes predictions at species level a difficult task, mainly in regions of higher biodiversity. To overcome this problem, we use native landcover as a surrogate biodiversity, because it can represent specialized habitat for species, and investigate the effects of future climate change on Brazilian biomes. We characterize the climatic niches of native landcover and use ecological niche modeling to predict the potential distribution under current and future climate scenarios...
May 22, 2017: Anais da Academia Brasileira de Ciências
https://www.readbyqxmd.com/read/28538792/-organizational-commitment-and-job-satisfaction-an-exploratory-study-in-family-health-units-in-portugal
#7
Isabel Pereira, Ana Veloso, Isabel Soares Silva, Patricio Costa
This study explored the relationship between organizational commitment and job satisfaction among workers in family health units. Six family health units in the North of Portugal participated, including 105 health professionals (physicians, nurses, and clinical secretaries). The study used the Portuguese adaptations of the Organizational Commitment Scale by Meyer & Allen (1997) and the Job Satisfaction Survey (Spector, 1985). The results suggest a positive association between organizational commitment and job satisfaction...
May 18, 2017: Cadernos de Saúde Pública
https://www.readbyqxmd.com/read/28538760/a-multivariate-model-for-prediction-of-obstructive-coronary-disease-in-patients-with-acute-chest-pain-development-and-validation
#8
Luis Cláudio Lemos Correia, Maurício Cerqueira, Manuela Carvalhal, Felipe Ferreira, Guilherme Garcia, André Barcelos da Silva, Nicole de Sá, Fernanda Lopes, Ana Clara Barcelos, Márcia Noya-Rabelo
Background: Currently, there is no validated multivariate model to predict probability of obstructive coronary disease in patients with acute chest pain. Objective: To develop and validate a multivariate model to predict coronary artery disease (CAD) based on variables assessed at admission to the coronary care unit (CCU) due to acute chest pain. Methods: A total of 470 patients were studied, 370 utilized as the derivation sample and the subsequent 100 patients as the validation sample...
April 2017: Arquivos Brasileiros de Cardiologia
https://www.readbyqxmd.com/read/28538758/same-tt2r2-score-in-the-outpatient-anticoagulation-clinic-to-predict-time-in-therapeutic-range-and-adverse-events
#9
Fernando Pivatto, Rafael Selbach Scheffel, Lucas Ries, Ricardo Roitman Wolkind, Roberta Marobin, Sabrina Sigal Barkan, Luís Carlos Amon, Andréia Biolo
Background: The SAMe-TT2R2 score was developed to predict which patients on oral anticoagulation with vitamin K antagonists (VKAs) will reach an adequate time in therapeutic range (TTR) (> 65%-70%). Studies have reported a relationship between this score and the occurrence of adverse events. Objective: To describe the TTR according to the score, in addition to relating the score obtained with the occurrence of adverse events in patients with nonvalvular atrial fibrillation (AF) on oral anticoagulation with VKAs...
April 2017: Arquivos Brasileiros de Cardiologia
https://www.readbyqxmd.com/read/28538731/a-neural-circuit-architecture-for-angular-integration-in-drosophila
#10
Jonathan Green, Atsuko Adachi, Kunal K Shah, Jonathan D Hirokawa, Pablo S Magani, Gaby Maimon
Many animals keep track of their angular heading over time while navigating through their environment. However, a neural-circuit architecture for computing heading has not been experimentally defined in any species. Here we describe a set of clockwise- and anticlockwise-shifting neurons in the Drosophila central complex whose wiring and physiology provide a means to rotate an angular heading estimate based on the fly's angular velocity. We show that each class of shifting neurons exists in two subtypes, with spatiotemporal activity profiles that suggest different roles for each subtype at the start and end of tethered-walking turns...
May 22, 2017: Nature
https://www.readbyqxmd.com/read/28538709/minimal-invasive-cystometry-and-intra-abdominal-pressure-assessments-in-rodents-a-novel-animal-study
#11
Yafei Yang, Jin Yang, Lin Chen, Jianyun Hu, Shasha Xing, Bastian Amend, Arnulf Stenzl, Xin Wei, Haifeng Hu
BACKGROUND The abdominal straining pattern can act as a novel parameter for improving the prediction of bladder outlet obstruction (BOO). To preserve detrusor function in the early stage of urinary system impairment, such as BOO, we establish a novel method for cystometry and Intra-abdominal pressure (IAP) assessments in rodents without cystostomy. MATERIAL AND METHODS Twenty mice and rats were divided into three groups (control, sham-operated and BOO group) respectively. The cystometry and IAP assessments were measured by the pediatric venous indwelling sheath and coronary dilatation catheter connected to Laborie urodynamic system on postoperative day 7...
May 24, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/28538688/in-silico-study-and-bioprospection-of-the-antibacterial-and-antioxidant-effects-of-flavone-and-its-hydroxylated-derivatives
#12
Camila de Albuquerque Montenegro, Gregório Fernandes Gonçalves, Abrahão Alves de Oliveira Filho, Andressa Brito Lira, Thays Thyara Mendes Cassiano, Natanael Teles Ramos de Lima, José Maria Barbosa-Filho, Margareth de Fátima Formiga Melo Diniz, Hilzeth Luna Freire Pessôa
Flavonoid compounds are widely used as natural protective species, which can act as anti-inflammatory, antioxidant, anticoagulant, antihypertensive and antitumor agents. This study set out to investigate the probable pharmacological activities, along with the antibacterial and antioxidant effects, of flavone and its hydroxy derivatives: 3-hydroxyflavone, 5-hydroxyflavone and 6-hydroxyflavone. To do so, we investigated their pharmacological characteristics, using in silico tests that indicate likelihood of activity or inactivity, with the PASS online software, and the antimicrobial potential against Gram positive and Gram negative bacteria was also analyzed, including bacteria of clinical importance...
May 24, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28538687/on-forgotten-topological-indices-of-some-dendrimers-structure
#13
Yasir Bashir, Adnan Aslam, Muhammad Kamran, Muhammad Imran Qureshi, Adnan Jahangir, Muhammad Rafiq, Nargis Bibi, Nazeer Muhammad
A series of previously conducted experiments pertaining to various chemicals and drugs uncover a natural linkage between the molecular structures and the bio-medical and pharmacological characteristics. The forgotten topological index computed for the molecular structures of various chemical compounds and drugs has proven significant in medical and pharmaceutical fields by predicting biological features of new chemical compounds and drugs. A topological index can be considered as the transformation of chemical structure into a real number...
May 24, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28538682/enteric-viruses-and-fecal-bacteria-indicators-to-assess-groundwater-quality-and-suitability-for-irrigation
#14
Osvalda De Giglio, Giuseppina Caggiano, Francesco Bagordo, Giovanna Barbuti, Silvia Brigida, Federica Lugoli, Tiziana Grassi, Giuseppina La Rosa, Luca Lucentini, Vito Felice Uricchio, Antonella De Donno, Maria Teresa Montagna
According to Italian Ministerial Decree No. 185 of 12 June 2003, water is considered suitable for irrigation if levels of fecal bacteria (i.e., Escherichia coli and Salmonella) are within certain parameters. The detection of other microorganisms is not required. The aim of this study is to determine the bacteriological quality of groundwater used for irrigation and the occurrence of enteric viruses (Norovirus, Enterovirus, Rotavirus, Hepatovirus A), and to compare the presence of viruses with the fecal bacteria indicators...
May 24, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28538668/biomechanical-modeling-of-pterygium-radiation-surgery-a-retrospective-case-study
#15
Bojan Pajic, Daniel M Aebersold, Andreas Eggspuehler, Frederik R Theler, Harald P Studer
Pterygium is a vascularized, invasive transformation on the anterior corneal surface that can be treated by Strontium-/Yttrium90 beta irradiation. Finite element modeling was used to analyze the biomechanical effects governing the treatment, and to help understand clinically observed changes in corneal astigmatism. Results suggested that irradiation-induced pulling forces on the anterior corneal surface can cause astigmatism, as well as central corneal flattening. Finite element modeling of corneal biomechanics closely predicted the postoperative corneal surface (astigmatism error -0...
May 24, 2017: Sensors
https://www.readbyqxmd.com/read/28538657/social-support-religious-involvement-and-alcohol-use-among-students-at-a-conservative-religious-university
#16
Wendy E Thompson
The misuse of alcohol among college students remains a significant public health concern in the United States. Excessive drinking among college students has been linked to numerous negative consequences, including rape, impaired academic performance, absenteeism from work and school and damaged social relations. This study examined whether religious involvement and social support played a role in reducing the frequency of alcohol use. A non-random convenience sample of 364 students from a larger study of 760 college students-18 years old and older-were recruited over a 2 month period...
May 24, 2017: Behavioral Sciences
https://www.readbyqxmd.com/read/28538634/intestinal-microcirculation-and-mucosal-oxygenation-during-hemorrhagic-shock-and-resuscitation-at-different-inspired-oxygen-concentrations
#17
Nicolas Libert, Anatole Harrois, Nathalie Baudry, Eric Vicaut, Jacques Duranteau
BACKGROUND: Hypotensive resuscitation is the standard of care of hemorrhagic shock resuscitation. The optimal level of arterial pressure is debated and there is a lack of data on relationships between arterial pressure, microcirculation and tissue oxygenation. We investigated the relationship between mean arterial pressure, intestinal microcirculation and mucosal oxygen tension during hemorrhagic shock and resuscitation at different inspired oxygen fraction concentration. METHODS: The study was divided into two phases: 32 mice were progressively exsanguinated and then transfused in MAP-titrated steps of 10 mmHg...
May 22, 2017: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/28538632/implications-of-the-tqip-inclusion-of-non-survivable-injuries-in-performance-benchmarking-tqip-inclusion-of-non-survivable-injuries
#18
Jiselle B Heaney, Rebecca Schroll, Jennifer Turney, Lance Stuke, Alan B Marr, Patrick Greiffenstein, Rosemarie Robledo, Amanda Theriot, Juan Duchesne, John Hunt
BACKGROUND: The Trauma Quality Improvement Project (TQIP) uses an injury prediction model for performance benchmarking. We hypothesize that at a level 1 high-volume penetrating trauma center, performance outcomes will be biased due to inclusion of patients with non-survivable injuries. METHODS: Retrospective chart review was conducted for all patients included in the institutional TQIP analysis from 2013-2014 with length of stay (LOS) < 1 day to determine survivability of the injuries...
May 22, 2017: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/28538625/a-metric-of-our-own-failure-to-rescue-after-trauma
#19
Daniel N Holena, Elinore J Kaufman, M Kit Delgado, Douglas J Wiebe, Brendan G Carr, Jason D Christie, Patrick M Reilly
BACKGROUND: Failure to rescue (FTR) is defined as death after an adverse event. The original metric was derived in elective surgical populations and reclassifies deaths not preceded by recorded adverse events as FTR cases under the assumption these deaths resulted from missed adverse events. This approach lacks face validity in trauma because patients often die without adverse events as a direct result of injury. Another common approach simply excludes deaths without recorded adverse events, but this approach reduces the reliability of the FTR metric...
May 22, 2017: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/28538624/comparison-of-compensatory-reserve-and-arterial-lactate-as-markers-of-shock-and-resuscitation
#20
Michael Johnson, Abdul Alarhayem, Victor Convertino, Robert Carter, Kevin Chung, Ronald Stewart, John Myers, Daniel Dent, Lilian Liao, Ramon Cestero, Susannah Nicholson, Mark Muir, Martin Schwaca, David Wampler, Mark DeRosa, Brian Eastridge
BACKGROUND: During traumatic hemorrhage, the ability to identify shock and intervene prior to decompensation is paramount to survival. Lactate is extremely sensitive to shock and its clearance has been demonstrated a useful gauge of shock and resuscitation status. Though lactate can be measured in the field, logistical constraints render it impractical in certain environments. The Compensatory Reserve represents a new clinical measurement reflecting the remaining capacity to compensate for hypoperfusion...
May 22, 2017: Journal of Trauma and Acute Care Surgery
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