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https://www.readbyqxmd.com/read/28240008/role-of-plasticity-region-genes-and-cage-gene-of-cagpai-of-helicobacter-pylori-in-development-of-gastrointestinal-gi-diseases
#1
Shokufe GholizadeTobnagh, Seyedeh Zahra Bakhti, Saeid Latifi Navid, Saber Zahri, Fatemeh Sadat Bakhti
Background: Helicobacter pylori is a Gram-negative, micro aerophilic bacterium in the human stomach that is associated with the development of gastrointestinal ailments such as peptic ulcer (PU) and gastric cancer (GC). In the present study, plasticity region genes (jhp0940, jhp0945 and jhp0947) and and cagE gene of cagPAI were assessed independently and in combination for their ability to predict clinical consequences. Materials and Methods: A total of 211 strains which were isolated from patients with different gastrointestinal diseases (114 with non-atrophic gastritis, 59 with PU, and 38 with GC) were genotyped by PCR and sequencing...
1, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/28240005/surgery-for-diverticulitis-in-the-21st-century-recent-evidence
#2
Arden M Morris, Cindy Kin
Sigmoid diverticulitis is an increasingly common disease in Western countries. As technology has led to increased knowledge about the disease and options for treatment, management strategies have become less certain. In previous years, the rationale for early elective surgery was largely preventive, due to concern that diverticulitis recurrence would result in increased risk of sepsis or the need for a colostomy. New technology has enabled diagnosis, through computed tomography scans, predictive information through clinical and administrative databases, and less invasive treatment options, through laparoscopic techniques...
February 24, 2017: Minerva Gastroenterologica e Dietologica
https://www.readbyqxmd.com/read/28239969/quantum-chemical-mass-spectrometry-ab-initio-prediction-of-electron-ionization-mass-spectra-and-identification-of-new-fragmentation-pathways
#3
Julie Cautereels, Magda Claeys, Davy Geldof, Frank Blockhuys
The electron ionization mass spectra of four organic compounds are predicted based on the results of quantum chemical calculations at the DFT/B3LYP/6-311 + G* level of theory. This prediction is performed 'ab initio', i.e. without any prior knowledge of the thermodynamics or kinetics of the reactions under consideration. Using a set of rules determining which routes will be followed, the fragmentation of the molecules' bonds and the complete resulting fragmentation pathways are studied. The most likely fragmentation pathways are identified based on calculated reaction energies ΔE when bond cleavage is considered and on activation energies ΔE(‡) when rearrangements are taken into account; the final intensities of the peaks in the spectrum are estimated from these values...
August 2016: Journal of Mass Spectrometry: JMS
https://www.readbyqxmd.com/read/28239914/-d-10-meld-as-a-novel-predictor-of-patient-and-graft-survival-after-adult-to-adult-living-donor-liver-transplantation
#4
Arvinder Singh Soin, Sanjay Goja, Sanjay Kumar Yadav, Tseten Yonjen Tamang, Amit Rastogi, Prashant Bhangui, S Thiagrajan, Vikram Raut, Raghvendra Y Babu, Neeraj Saraf, Narendra Singh Chaudhary, Vijay Vohara
We modified the previously described DMELD score in deceased donor liver transplant, to (D+10)MELD to account for living donors being about 10 years younger than deceased donors, and tested it on living donor liver transplantation (LDLT) recipients. 500 consecutive LDLT, between July 2010 and December 2012 were retrospectively analyzed to see the effect of (D+10)MELD on patient and graft survival. Donor age alone did not influence survival. Recipients were divided into 6 classes on based on the (D+10)MELD score: Class 1 (0-399), Class 2 (400-799), Class 3 (800-1199), class 4 (1200-1599), Class 5 (1600-1999) and Class 6 (>2000)...
February 26, 2017: Clinical Transplantation
https://www.readbyqxmd.com/read/28239897/population-pharmacokinetics-of-rituximab-in-patients-with-diffuse-large-b-cell-lymphoma-and-association-with-clinical-outcome
#5
S Rozman, I Grabnar, S Novaković, A Mrhar, B J Novaković
AIMS: Pharmacokinetic (PK) studies suggest that there is a room for improvement in clinical use of rituximab through more individualized treatment. The objective of this study was to characterize rituximab PK in 29 newly diagnosed patients with diffuse large B-cell lymphoma treated with rituximab in combination with cyclophosphamide, doxorubicin, vincristine and methylprednisolone every three weeks. We also evaluated the association of rituximab PK with clinical outcome. METHODS: Rituximab serum levels were determined by enzyme-linked immunosorbent assay and evaluated by a population PK analysis applying non-linear mixed effects modelling...
February 27, 2017: British Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/28239876/the-potential-of-volatile-organic-compounds-for-the-detection-of-active-disease-in-patients-with-ulcerative-colitis
#6
A Smolinska, A G L Bodelier, J W Dallinga, A A M Masclee, D M Jonkers, F-J van Schooten, M J Pierik
BACKGROUND: To optimise treatment of ulcerative colitis (UC), patients need repeated assessment of mucosal inflammation. Current non-invasive biomarkers and clinical activity indices do not accurately reflect disease activity in all patients and cannot discriminate UC from non-UC colitis. Volatile organic compounds (VOCs) in exhaled air could be predictive of active disease or remission in Crohn's disease. AIM: To investigate whether VOCs are able to differentiate between active UC, UC in remission and non-UC colitis...
February 26, 2017: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/28239869/intra-patient-variability-in-adalimumab-drug-levels-within-and-between-cycles-in-crohn-s-disease
#7
M G Ward, P A Thwaites, L Beswick, J Hogg, G Rosella, D Van Langenberg, J Reynolds, P R Gibson, M P Sparrow
BACKGROUND: Whether therapeutic drug monitoring for adalimumab needs to be performed at the trough concentration has not been defined. AIM: To determine intra-patient adalimumab drug-level variation and to identify modulating patient and disease factors. METHODS: In this prospective observational study, adult patients with Crohn's disease established on maintenance adalimumab had drug levels measured repeatedly according to pre-defined schedules (visit 1: day 4-6, visit 2: day 7-9, trough: day 13-14) across two consecutive fortnightly cycles...
February 27, 2017: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/28239838/which-matters-more-a-retrospective-cohort-study-of-headache-characteristics-and-diagnosis-type-in-soldiers-with-mtbi-concussion
#8
Alan G Finkel, Brian J Ivins, Juanita A Yerry, John S Klaric, Ann Scher, Y Sammy Choi
OBJECTIVE: To describe the diagnostic types and characteristics of headaches in soldiers with mild traumatic brain injury during the wars in Afghanistan and Iraq. BACKGROUND: Persistent post-traumatic headache interferes with returns to activity or duty. The most commonly cited headache diagnosis after concussion is migraine. We hypothesize that headache diagnosis type, eg, migraine, is not sufficient to predict relationships with occupational outcomes after concussion...
February 27, 2017: Headache
https://www.readbyqxmd.com/read/28239834/order-constrained-linear-optimization
#9
Joe W Tidwell, Michael R Dougherty, Jeffrey S Chrabaszcz, Rick P Thomas
Despite the fact that data and theories in the social, behavioural, and health sciences are often represented on an ordinal scale, there has been relatively little emphasis on modelling ordinal properties. The most common analytic framework used in psychological science is the general linear model, whose variants include ANOVA, MANOVA, and ordinary linear regression. While these methods are designed to provide the best fit to the metric properties of the data, they are not designed to maximally model ordinal properties...
February 27, 2017: British Journal of Mathematical and Statistical Psychology
https://www.readbyqxmd.com/read/28239824/long-non-coding-rna-cche1-overexpression-predicts-a-poor-prognosis-for-cervical-cancer
#10
Y Chen, C-X Wang, X-X Sun, C Wang, T-F Liu, D-J Wang
OBJECTIVE: Our study is intended to explore the correlation of long non-coding RNA CCHE1 (CCHE1) and clinicopathological factors of cervical cancer patients, and evaluate the impact of CCHE1 on the prognosis of cervical cancer. PATIENTS AND METHODS: The CCHE1 expression in cervical cancer tissues was examined by quantitative Real-time PCR (qRT-PCR) and its correlation with clinicopathological features was also analyzed. A Kaplan-Meier survival curve was generated following a log-rank test...
February 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28239821/analysis-of-circulating-long-non-coding-rna-uca1-as-potential-biomarkers-for-diagnosis-and-prognosis-of-osteosarcoma
#11
J-J Wen, Y-D Ma, G-S Yang, G-M Wang
OBJECTIVE: The aim of this investigation was to examine the potential usefulness of long non-coding RNA UCA1 (UCA1) as a biomarker for diagnosis and prognosis in osteosarcoma. PATIENTS AND METHODS: The expression level of UCA1 was determined using TaqMan real-time PCR in human osteosarcoma tissues and patients' sera. Next, we investigated to clarify the relationship of UCA1 with clinicopathological features. The receiver operating characteristic (ROC) curve was performed to estimate the diagnostic value of UCA1...
February 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28239818/identification-of-mir-146b-5p-in-tissues-as-a-novel-biomarker-for-prognosis-of-gallbladder-carcinoma
#12
Y-P Lv, W Shi, H-X Liu, X-J Kong, D-L Dai
OBJECTIVE: Increasing evidence has suggested that dysregulation of microRNAs (miRNAs) could contribute to tumor progression. The aim of present study was to evaluate the feasibility of using miR-146b-5p as a prognostic biomarker in gallbladder cancer (GBC). PATIENTS AND METHODS: We collected 150 pairs of tissue specimens from patients with GBC and adjacent normal specimens. The expression level of miR-146b-5p was measured in 150 GBC tissues and adjacent normal tissues RT-qPCR...
February 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28239809/association-between-the-plasma-levels-of-ima-and-coronary-atherosclerotic-plaque-burden-and-ischemic-burden-in-early-phase-of-non-st-segment-elevation-acute-coronary-syndromes
#13
T Turan, A R Akyüz, S Sahin, S Kul, A S Yilmaz, F Kara, S O Mentese, A Ç Aykan, S Demir, S Celik, S C Karahan
OBJECTIVE: Ischemia-modified albumin (IMA), a novel biochemical marker, is known to reflect ischemia in early phases of acute coronary syndrome (ACS). In the present study, we evaluated the role of IMA on the prediction of coronary atherosclerotic plaque burden and ischemic burden in patients with non-ST-segment-elevation acute coronary syndromes (NSTEACS). PATIENTS AND METHODS: Ninety-six consecutive NSTEACS patients presented within the first three hours of symptom onset were prospectively enrolled in this study...
February 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28239808/atrial-fibrillation-prevalence-and-atrial-vulnerability-analysis-in-paroxysmal-supraventricular-tachycardia-patients-after-radiofrequency-ablation
#14
Q-X Zhao, Y-M Zhao, L Mao, D-L Shen, X-Y Zhao
OBJECTIVE: Paroxysmal supraventricular tachycardia (PSVT) patient has higher prevalence ratio of atrial fibrillation (AF), while AF recurrence remains a high ratio after radiofrequency ablation (RFCA). This study explored AF prevalence and atrial vulnerability in PSVT patients after RFCA, using ROC curve to analyze atrial effective refractory period dispersion (dERP) on postoperative AF in the prediction of PSVT. PATIENTS AND METHODS: The PSVT patients were enrolled and divided into three groups and received RFCA treatment between January 2010 and December 2014...
February 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28239800/intermediate-cd14-cd16-monocyte-predicts-severe-coronary-stenosis-and-extensive-plaque-involvement-in-asymptomatic-individuals
#15
Shyh-Chyi Lo, Wen-Jeng Lee, Ching-Yi Chen, Bai-Chin Lee
Circulating leukocyte subtypes and monocyte subsets are independent predictors of cardiovascular events. We hypothesized that an increased leukocyte subtype would predict severe coronary stenosis and extensive plaque involvement. We retrospectively analyzed clinical, laboratory, and coronary CT data in a total of 588 asymptomatic adults (69% men; mean age, 57 ± 9 years) undergoing a general health check-up. Intermediate CD14(++)CD16(+) monocyte count had the strongest association with mixed and calcified plaque scores, whereas the numbers of neutrophils and classical CD14(++)CD16(-) monocytes were significantly associated with non-calcified plaque score...
February 26, 2017: International Journal of Cardiovascular Imaging
https://www.readbyqxmd.com/read/28239779/variation-in-barley-1%C3%A2-%C3%A2-3-1%C3%A2-%C3%A2-%C3%A2-4-%C3%AE-glucan-endohydrolases-reveals-novel-allozymes-with-increased-thermostability
#16
Juanita C Lauer, Suong Cu, Rachel A Burton, Jason K Eglinton
Novel barley (1 → 3, 1 → 4)-β-glucan endohydrolases with increased thermostability. Rapid and reliable degradation of (1 → 3, 1 → 4)-β-glucan to produce low viscosity wort is an essential requirement for malting barley. The (1 → 3, 1 → 4)-β-glucan endohyrolases are responsible for the primary hydrolysis of cell wall β-glucan. The variation in β-glucanase genes HvGlb1 and HvGlb2 that encode EI and EII, respectively, were examined in elite and exotic germplasm. Six EI and 14 EII allozymes were identified, and significant variation was found in β-glucanase from Hordeum vulgare ssp...
February 26, 2017: TAG. Theoretical and Applied Genetics. Theoretische und Angewandte Genetik
https://www.readbyqxmd.com/read/28239758/acellular-mouse-kidney-ecm-can-be-used-as-a-three-dimensional-substrate-to-test-the-differentiation-potential-of-embryonic-stem-cell-derived-renal-progenitors
#17
Manpreet Sambi, Theresa Chow, Jennifer Whiteley, Mira Li, Shawn Chua, Vanessa Raileanu, Ian M Rogers
The development of strategies for tissue regeneration and bio-artificial organ development is based on our understanding of embryogenesis. Differentiation protocols attempt to recapitulate the signaling modalities of gastrulation and organogenesis, coupled with cell selection regimens to isolate the cells of choice. This strategy is impeded by the lack of optimal in vitro culture systems since traditional culture systems do not allow for the three-dimensional interaction between cells and the extracellular matrix...
February 27, 2017: Stem Cell Reviews
https://www.readbyqxmd.com/read/28239757/predictive-factor-of-secondary-tricuspid-regurgitation-after-aortic-valve-replacement-for-aortic-stenosis-the-importance-of-myocardial-hypertrophy-and-diastolic-dysfunction
#18
Takashi Igarashi, Masahiro Tanji, Koki Takahashi, Keiichi Ishida, Satomi Sasaki, Hitoshi Yokoyama
OBJECTIVES: The aim of this study is to determine the predictors of secondary tricuspid regurgitation after aortic valve replacement for aortic stenosis. METHODS: Seventy-one patients, who underwent aortic valve replacement for aortic stenosis at our institute from January 2006 to July 2011, were divided into two groups: an STR group, which included 15 patients with moderate or greater than moderate secondary tricuspid regurgitation at a follow-up visit and a control group...
February 26, 2017: General Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/28239753/six-minute-walk-test-in-evaluation-of-children-with-pulmonary-arterial-hypertension
#19
Malgorzata Zuk, Anna Migdal, Dorota Jagiellowicz-Kowalska, Katarzyna Mazurkiewicz, Anna Sadel-Wieczorek, Grazyna Brzezinska-Rajszys
Six-minute walk test (6MWT) is a submaximal exercise test applied for evaluation of adults with pulmonary arterial hypertension (PAH). It was widely used as an endpoint in the clinical trials. The aim of the study was to assess the usefulness of 6MWT in management of children with PAH and to establish correlations with other clinical features. 164 6MWT were performed in 15 children between 5 and 18 years with PAH confirmed by right heart catheterization (102 in patients with shunt, 62 without shunt). Distance in 6MWT (6MWD)-% of predicted for age and gender, desaturation at the maximum effort, peak heart rate (HR)-% of maximal HR, were compared to the level of NTproBNP, WHO-FC, echocardiography parameters, and events of PAH treatment intensification...
February 27, 2017: Pediatric Cardiology
https://www.readbyqxmd.com/read/28239717/simulations-and-spectra-of-water-in-co-matrices
#20
Rafael Escribano, Emilio Artacho, Akira Kouchi, Tetusya Hama, Yuki Kimura, Hiroshi Hidaka, Naoki Watanabe
Models for the inclusion of water molecules in carbon monoxide matrices are developed using density functional theory applied to amorphous solid systems. The models cover a large range of systems for smaller or larger CO matrices with different water content, consisting of either individual H2O molecules or small clusters linked by H-bonds. The vibrational spectra of the samples are predicted at the minimum of their potential energy surface. The spectra allow instances where the water molecules remain isolated or form aggregates to be discerned, and they also provide an indication of the strength of the H-bonding, when present...
February 27, 2017: Physical Chemistry Chemical Physics: PCCP
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