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Posttraumatic osteoarthritis AND knee

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https://www.readbyqxmd.com/read/29678170/self-reported-functional-recovery-after-reconstruction-versus-repair-in-acute-anterior-cruciate-ligament-rupture-rotor-a-randomized-controlled-clinical-trial
#1
Barbara C Boer, Roy A G Hoogeslag, Reinoud W Brouwer, Anna Demmer, Rianne M H A Huis In 't Veld
BACKGROUND: Anterior cruciate ligament (ACL) reconstruction is today's surgical gold standard for ACL rupture. Although it provides satisfactory results, not all patients return to their previous activity level and moreover, early posttraumatic osteoarthritis is not prevented. As such, a renewed interest has emerged in ACL suture repair combined with dynamic augmentation. Compared to ACL reconstruction, the hypothesized advantages of ACL suture repair are earlier return to sports, reduction of early posttraumatic osteoarthritis and preservation of the patient's native ACL tissue and proprioceptive envelope of the knee...
April 20, 2018: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/29668309/posttraumatic-osteoarthritis-development-and-progression-in-an-ovine-model-of-partial-anterior-cruciate-ligament-transection-and-effect-of-repeated-intra-articular-methylprednisolone-acetate-injections-on-early-disease
#2
Kristen I Barton, Bryan J Heard, Johnathan L Sevick, C Ryan Martin, S M Mehdi Shekarforoush, May Chung, Yamini Achari, Cyril B Frank, Nigel G Shrive, David A Hart
BACKGROUND: Partial anterior cruciate ligament (p-ACL) ruptures are a common injury of athletes. However, few preclinical models have investigated the natural history and treatment of p-ACL injuries. PURPOSE: To (1) demonstrate whether a controlled p-ACL injury model (anteromedial band transection) develops progressive gross morphological and histological posttraumatic osteoarthritis (PTOA)-like changes at 20 and 40 weeks after the injury and (2) investigate the efficacy of repeated (0, 5, 10, and 15 weeks) intra-articular injections of methylprednisolone acetate (MPA; 80 mg/mL) in the mitigation of potential PTOA-like changes after p-ACL transection...
April 1, 2018: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/29667844/lower-extremity-biomechanics-during-a-drop-vertical-jump-in-participants-with-or-without-chronic-ankle-instability
#3
C Collin Herb, Kaitlyn Grossman, Mark A Feger, Luke Donovan, Jay Hertel
CONTEXT:   Chronic ankle instability (CAI) is a condition characterized by range-of-motion, neuromuscular, and postural-control deficits and subjective disability, reinjury, and posttraumatic osteoarthritis. Differences have been reported in kinematics, kinetics, surface electromyography (EMG), and ground reaction forces during functional tasks performed by those with CAI. These measures are often collected independently, and the research on collecting measures simultaneously during a movement task is limited...
April 18, 2018: Journal of Athletic Training
https://www.readbyqxmd.com/read/29629916/distal-femoral-varus-osteotomy-for-the-management-of-valgus-deformity-of-the-knee
#4
Seth L Sherman, Samuel F Thompson, John C F Clohisy
Distal femoral varus osteotomy is a well-described treatment option for patients with valgus malalignment associated with a variety of underlying conditions. This procedure may be the definitive treatment option in active patients with isolated lateral compartment osteoarthritis or posttraumatic arthritis. It may be a useful concomitant procedure in young patients with lateral meniscus deficiency, focal chondral defects, chronic medial collateral ligament insufficiency, and/or patellofemoral instability. Distal femoral varus osteotomy can be performed with medial closing wedge or lateral opening wedge techniques...
May 1, 2018: Journal of the American Academy of Orthopaedic Surgeons
https://www.readbyqxmd.com/read/29608139/senescent-cells-and-osteoarthritis-a-painful-connection
#5
Ok Hee Jeon, Nathaniel David, Judith Campisi, Jennifer H Elisseeff
Senescent cells (SnCs) are associated with age-related pathologies. Osteoarthritis is a chronic disease characterized by pain, loss of cartilage, and joint inflammation, and its incidence increases with age. For years, the presence of SnCs in cartilage isolated from patients undergoing total knee artificial implants has been noted, but these cells' relevance to disease was unclear. In this Review, we summarize current knowledge of SnCs in the multiple tissues that constitute the articular joint. New evidence for the causative role of SnCs in the development of posttraumatic and age-related arthritis is reviewed along with the therapeutic benefit of SnC clearance...
April 2, 2018: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/29529627/no-benefit-of-computer-assisted-tka-10-year-results-of-a-prospective-randomized-study
#6
Matthieu Ollivier, Sébastien Parratte, Ludovic Lino, Xavier Flecher, Sébastien Pesenti, Jean-Noël Argenson
BACKGROUND: Previously published studies reported benefits of computer-assisted surgery (CAS) in terms of radiographic implant position in TKA, but whether these improvements result in clinically important survival differences or functional differences that a patient might perceive at a minimum 10-year followup remains largely unknown. QUESTIONS/PURPOSES: We performed a prospective randomized trial and asked whether CAS (1) improved survival free from aseptic loosening; and (2) demonstrated any clear difference in patient-reported outcomes at latest followup using validated outcome measures at minimum 10-year followup...
January 2018: Clinical Orthopaedics and related Research
https://www.readbyqxmd.com/read/29511786/-anatomical-total-shoulder-replacement-in-glenohumeral-osteoarthritis-indications-current-implants-and-clinical-results
#7
REVIEW
O Lorbach
IMPLANT DESIGNS: Within the last 50 years, implants for shoulder replacement have developed rapidly. Monobloc-stems in few sizes were changed to modular implant systems that allow for an individual adaption of the stem, as well as adaption of the humeral head component according to the specific anatomic situation of the patient. Moreover, stemless und short stem implants are available, which may highly simplify primary implantation, especially in posttraumatic cases as well as in revision cases with a need for removal or change of the implants...
May 2018: Der Orthopäde
https://www.readbyqxmd.com/read/29469223/mitoprotective-therapy-preserves-chondrocyte-viability-and-prevents-cartilage-degeneration-in-an-ex-vivo-model-of-posttraumatic-osteoarthritis
#8
Michelle L Delco, Edward D Bonnevie, Hazel S Szeto, Lawrence J Bonassar, Lisa A Fortier
No disease-modifying osteoarthritis (OA) drugs are available to prevent posttraumatic osteoarthritis (PTOA). Mitochondria (MT) mediate the pathogenesis of many degenerative diseases, and recent evidence indicates that MT dysfunction is a peracute (within minutes to hours) response of cartilage to mechanical injury. The goal of this study was to investigate cardiolipin-targeted mitoprotection as a new strategy to prevent chondrocyte death and cartilage degeneration after injury. Cartilage was harvested from bovine knee joints and subjected to a single, rapid impact injury (24...
February 22, 2018: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/29456776/what-percentage-of-patients-is-a-candidate-for-unicompartmental-knee-replacement-at-a-chinese-arthroplasty-center
#9
Yong He, Lianbo Xiao, Weitao Zhai, Maximilian F Kasparek, Guilin Ouyang, Friedrich Boettner
Background: Data on indication of Unicompartmental Knee Arthroplasty (UKA) in the Asian population are currently not available. The current paper evaluates patients undergoing knee replacement at a Chinese Orthopaedic Specialty Hospital to report the percentage of patients who meet radiographic and clinical indication criteria for UKA. Methods: Over a one-year period 463 consecutive patients (515 knees) underwent primary knee replacement surgery. Clinical data were recorded and preoperative radiographs were assessed...
2018: Open Orthopaedics Journal
https://www.readbyqxmd.com/read/29409817/botulinum-toxin-treatment-of-pain-syndromes-an-evidence-based-review
#10
Yasaman Safarpour, Bahman Jabbari
This review evaluates the existing level of evidence for efficacy of BoNTs in different pain syndromes using the recommended efficacy criteria from the Assessment and Therapeutic Subcommittee of the American Academy of Neurology. There is a level A evidence (effective) for BoNT therapy in post-herpetic neuralgia, trigeminal neuralgia, and posttraumatic neuralgia. There is a level B evidence (probably effective) for diabetic neuropathy, plantar fasciitis, piriformis syndrome, pain associated with total knee arthroplasty, male pelvic pain syndrome, chronic low back pain, male pelvic pain, and neuropathic pain secondary to traumatic spinal cord injury...
June 1, 2018: Toxicon: Official Journal of the International Society on Toxinology
https://www.readbyqxmd.com/read/29394877/differences-in-the-lateral-compartment-joint-space-width-after-anterior-cruciate-ligament-reconstruction-data-from-the-moon-onsite-cohort
#11
Morgan H Jones, Kurt P Spindler, Jack T Andrish, Charles L Cox, Warren R Dunn, Jeff Duryea, Carol L Duong, David C Flanigan, Braden C Fleming, Laura J Huston, Christopher C Kaeding, Matthew J Matava, Nancy A Obuchowski, Heidi L Oksendahl, Richard D Parker, Erica A Scaramuzza, Matthew V Smith, Carl S Winalski, Rick W Wright, Emily K Reinke
BACKGROUND: Anterior cruciate ligament (ACL) reconstruction can effectively return athletes to the playing field, but they are still at risk of developing posttraumatic osteoarthritis (PTOA). No studies have used multivariable analysis to evaluate the predictors of radiographic PTOA in the lateral compartment of the knee at short-term follow-up after ACL reconstruction. PURPOSE: To determine the predictors of radiographic joint space narrowing in the lateral compartment 2 to 3 years after ACL reconstruction in a young, active cohort...
March 2018: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/29364702/synovial-fluid-profile-at-the-time-of-anterior-cruciate-ligament-reconstruction-and-its-association-with-cartilage-matrix-composition-3-years-after-surgery
#12
Keiko Amano, Janet L Huebner, Thomas V Stabler, Matthew Tanaka, Charles E McCulloch, Iryna Lobach, Nancy E Lane, Virginia B Kraus, C Benjamin Ma, Xiaojuan Li
BACKGROUND: Anterior cruciate ligament tears can lead to posttraumatic osteoarthritis. In addition to biomechanical factors, changes in biochemical profiles within the knee joint after injury and anterior cruciate ligament reconstruction (ACLR) may play a role in accelerating joint degeneration. Hypothesis/Purpose: It was hypothesized that cartilage matrix composition after ACLR is associated with the degree of inflammatory response after initial injury. This study evaluated the association between the inflammatory response after injury-as indicated by cytokine, metalloproteinase, and cartilage degradation marker concentrations in synovial fluid-and articular cartilage degeneration, measured by T1ρ and T2 quantitative magnetic resonance imaging up to 3 years after ACLR...
March 2018: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/29356798/staged-prone-supine-fixation-of-high-energy-multicolumnar-tibial-plateau-fractures-a-multicenter-analysis
#13
Elliot R Row, David E Komatsu, J Tracy Watson, Clifford Jones, Stephen Kottmeier
PURPOSE: We present a surgical strategy to manage multicolumnar tibial plateau fracture variants by addressing the predominant posterior fragment employing a Lobenhoffer approach in the prone position followed by supine patient repositioning for anterolateral column access. DESIGN: Multicenter retrospective analysis. SETTING: Three academic Level 1 trauma centers. PATIENTS/METHODS: Twenty-eight cases (28 patients/28 knees) met inclusion criteria between 2003 and 2014...
April 2018: Journal of Orthopaedic Trauma
https://www.readbyqxmd.com/read/29197416/joint-awareness-in-posttraumatic-osteoarthritis-of-the-knee-validation-of-the-forgotten-joint-score-in-long-term-condition-after-tibial-plateau-fracture
#14
Florian Baumann, Johannes Weber, Daniel Mahr, Martin Bäumlein, Maximilian Kerschbaum, Karolina Müller, Paavo Rillmann, Michael Nerlich, Markus Loibl
BACKGROUND: Evaluating patient-reported outcomes (PRO) in early osteoarthritis (OA) of the knee is difficult. Established measurement tools are focused on one of the two major patient groups in knee surgery: young, highly active patients, or older patients with advanced degenerative OA of the knee. Joint awareness in everyday life is a crucial criterion in measuring PRO. The purpose of this study was to validate a German version of the "Forgotten Joint Score" (FJS) in patients after surgical treatment of tibial plateau fractures...
December 2, 2017: Health and Quality of Life Outcomes
https://www.readbyqxmd.com/read/29154697/rate-of-subtalar-joint-arthrodesis-after-retrograde-tibiotalocalcaneal-arthrodesis-with-intramedullary-nail-fixation-evaluation-of-the-rain-database
#15
Michael Dujela, Christopher F Hyer, Gregory C Berlet
BACKGROUND: Hindfoot arthritis or significant deformity involving the ankle and subtalar joint (STJ) is a disabling condition with few salvage options. Many surgeons note a decreased STJ fusion rate compared with ankle union when a retrograde nail construct is used. The purpose of this study was to report the STJ fusion rate of tibiotalocalcaneal (TTC) arthrodesis with retrograde nail. METHODS: A chart and radiographic review was performed. TTC fusions performed in patients with osteoarthritis, posttraumatic arthritis, or deformity correction with retrograde nail fixation were included...
November 1, 2017: Foot & Ankle Specialist
https://www.readbyqxmd.com/read/28982255/high-rates-of-osteoarthritis-develop-after-anterior-cruciate-ligament-surgery-an-analysis-of-4108-patients
#16
Mark E Cinque, Grant J Dornan, Jorge Chahla, Gilbert Moatshe, Robert F LaPrade
BACKGROUND: Posttraumatic osteoarthritis (PTOA) after anterior cruciate ligament (ACL) reconstruction ultimately translates into a large economic effect on the health care system owing to the young ages of this population. Purpose/Hypothesis: The purposes were to perform a meta-analysis to determine the prevalence of osteoarthritis after an ACL reconstruction, examining the effects of length of time after surgery, preoperative time interval from injury to surgery, and patient age at the time of surgery...
September 1, 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/28875154/structural-and-anatomic-restoration-of-the-anterior-cruciate-ligament-is-associated-with-less-cartilage-damage-1-year-after-surgery-healing-ligament-properties-affect-cartilage-damage
#17
Ata M Kiapour, Braden C Fleming, Martha M Murray
BACKGROUND: Abnormal joint motion has been linked to joint arthrosis after anterior cruciate ligament (ACL) reconstruction. However, the relationships between the graft properties (ie, structural and anatomic) and extent of posttraumatic osteoarthritis are not well defined. HYPOTHESES: (1) The structural (tensile) and anatomic (area and alignment) properties of the reconstructed graft or repaired ACL correlate with the total cartilage lesion area 1 year after ACL surgery, and (2) side-to-side differences in anterior-posterior (AP) knee laxity correlate with the total cartilage lesion area 1 year postoperatively...
August 2017: Orthopaedic Journal of Sports Medicine
https://www.readbyqxmd.com/read/28768432/effects-of-surgical-factors-on-cartilage-can-be-detected-using-quantitative-magnetic-resonance-imaging-after-anterior-cruciate-ligament-reconstruction
#18
Keiko Amano, Alan K Li, Valentina Pedoia, Matthew F Koff, Aaron J Krych, Thomas M Link, Hollis Potter, Scott Rodeo, Xiaojuan Li, C Benjamin Ma, Sharmila Majumdar
BACKGROUND: Quantitative magnetic resonance (qMR) can be used to measure macromolecules in tissues and is a potential method of observing early cartilage changes in the development of posttraumatic osteoarthritis. Hypothesis/Purpose: We hypothesized that specific patient and surgical factors affecting cartilage matrix composition after anterior cruciate ligament (ACL) reconstruction (ACLR) can be detected using T1ρ and T2 relaxation times. Our purpose was to demonstrate this ability in a multicenter feasibility study...
April 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/28730928/feasibility-of-na-18-f-pet-ct-and-mri-for-noninvasive-in-vivo-quantification-of-knee-pathophysiological-bone-metabolism-in-a-canine-model-of-post-traumatic-osteoarthritis
#19
Maria I Menendez, Bianca Hettlich, Lai Wei, Michael V Knopp
PURPOSE: To assess and quantify by molecular imaging knee osseous metabolic changes serially in an in vivo canine model of posttraumatic osteoarthritis (PTOA) of the knee utilizing sodium fluoride (Na18 F) positron emission tomography (PET)/computed tomography (CT) coregistered with magnetic resonance imaging (MRI). MATERIALS AND METHODS: Sodium fluoride PET imaging of 5 canines was performed prior to anterior cruciate ligament transection (ACLT) and 2 times post-ACLT (3 and 12 weeks)...
January 2017: Molecular Imaging
https://www.readbyqxmd.com/read/28653872/posttraumatic-bone-marrow-lesion-volume-and-knee-pain-within-4-weeks-after-anterior-cruciate-ligament-injury
#20
RANDOMIZED CONTROLLED TRIAL
Jeffrey B Driban, Stefan Lohmander, Richard B Frobell
CONTEXT:   After an anterior cruciate ligament (ACL) injury, a majority of patients have a traumatic bone marrow lesion (BML, or bone bruise). The clinical relevance of posttraumatic lesions remains unclear. OBJECTIVE:   To explore the cross-sectional associations between traumatic BML volume and self-reported knee pain and symptoms among individuals within 4 weeks of ACL injury. DESIGN:   Cross-sectional exploratory analysis of a randomized clinical trial...
June 2, 2017: Journal of Athletic Training
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