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Posttraumatic osteoarthritis AND knee

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https://www.readbyqxmd.com/read/28420082/can-early-rehabilitation-prevent-posttraumatic-osteoarthritis-in-the-patellofemoral-joint-after-anterior-cruciate-ligament-rupture-understanding-the-pathological-features
#1
Nai-Jen Chang, Ming-You Shie, Kuan-Wei Lee, Pei-Hsi Chou, Chih-Chan Lin, Chih-Jou Chu
Knee instability resulting from anterior cruciate ligament (ACL) rupture is a high-risk factor for posttraumatic osteoarthritis (PTOA) in the patellofemoral joint (PFJ). However, whether non-weight-bearing and weight-bearing treatments have chondroprotective effects remains unclear. Twenty-four adult New Zealand White male rabbits were employed in this study. All animals received ACL transection in the right knee and sham surgery in the left knee. The rabbits were randomly assigned to the following groups: (I) In the sedentary (SED) group, the rabbits (n = 6) were simply kept in their cage; (II) In the continuous passive motion (CPM) group, the rabbits (n = 6) performed CPM exercise for 7 days, starting from the first postoperative day; (III) In the active treadmill exercise (TRE) group, the rabbits (n = 6) performed TRE for 2 weeks; (IV) In the CPM + TRE group, the rabbits (n = 6) executed CPM exercise, followed by TRE...
April 14, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28388231/sex-differences-in-high-school-athletes-knowledge-of-sport-related-concussion-symptoms-and-reporting-behaviors
#2
Jessica Wallace, Tracey Covassin, Erica Beidler
CONTEXT:   Recent researchers have reported that athletes' knowledge of sport-related concussion (SRC) has increased but that athletes still lack knowledge of all the signs and symptoms of SRC. Understanding the signs and symptoms of SRC and the dangers of playing while symptomatic are critical to reporting behaviors in high school athletes. OBJECTIVE:   To examine sex differences in knowledge of SRC symptoms and reasons for not reporting a suspected SRC to an authoritative figure in high school athletes...
April 18, 2017: Journal of Athletic Training
https://www.readbyqxmd.com/read/28384173/daily-oral-consumption-of-hydrolyzed-type-1-collagen-is-chondroprotective-and-anti-inflammatory-in-murine-posttraumatic-osteoarthritis
#3
Qurratul-Ain Dar, Eric M Schott, Sarah E Catheline, Robert D Maynard, Zhaoyang Liu, Fadia Kamal, Christopher W Farnsworth, John P Ketz, Robert A Mooney, Matthew J Hilton, Jennifer H Jonason, Janne Prawitt, Michael J Zuscik
Osteoarthritis (OA) is a degenerative joint disease for which there are no disease modifying therapies. Thus, strategies that offer chondroprotective or regenerative capability represent a critical unmet need. Recently, oral consumption of a hydrolyzed type 1 collagen (hCol1) preparation has been reported to reduce pain in human OA and support a positive influence on chondrocyte function. To evaluate the tissue and cellular basis for these effects, we examined the impact of orally administered hCol1 in a model of posttraumatic OA (PTOA)...
2017: PloS One
https://www.readbyqxmd.com/read/28367692/operative-wound-complications-following-total-ankle-arthroplasty
#4
Christopher E Gross, Kamran S Hamid, Cynthia Green, Mark E Easley, James K DeOrio, James A Nunley
BACKGROUND: Wound complications following total ankle replacement (TAR) potentially lead to devastating consequences. The aim of this study was to compare the operative and demographic differences in patients with and without major wound problems which required operative management. We hypothesized that increased tourniquet and operative time would negatively influence wound healing. METHODS: We identified a consecutive series of 762 primary TARs performed between December 1999 and April 2014 whose data were prospectively collected...
April 2017: Foot & Ankle International
https://www.readbyqxmd.com/read/28355681/a-biomechanical-study-of-two-distinct-methods-of-anterior-cruciate-ligament-rupture-and-a-novel-surgical-reconstruction-technique-in-a-small-animal-model-of-posttraumatic-osteoarthritis
#5
Austin J Ramme, Matin S Lendhey, Eric J Strauss, Oran D Kennedy
Small animal models are critical for studies of sports-related knee injury and disease such as posttraumatic osteoarthritis (PTOA) following anterior cruciate ligament (ACL) rupture. In such models, ACL damage can be achieved by surgical transection or, using a more recent innovation, by noninvasive biomechanical means. Whether these approaches differentially alter normal mechanics is unknown. Furthermore, while surgical reconstruction of ruptured ACL can greatly improve joint stability, its effect on PTOA development is also unclear...
March 29, 2017: Journal of Knee Surgery
https://www.readbyqxmd.com/read/28345409/osteoarthritis-in-football
#6
Gian M Salzmann, Stefan Preiss, Marcy Zenobi-Wong, Laurent P Harder, Dirk Maier, Jirí Dvorák
Football is currently the most popular sporting activity in the world. Multiple reports have shown that a high incidence of osteoarthritis is found in football players. Evidence clearly shows that traumatic injury significantly predisposes players for such pathophysiology. Injuries are frequent in amateur as well as professional football players, with knee and ankle accounting for the most severe injuries. Many professional athletes lose playing time due to injuries and many are forced into early retirement...
April 2017: Cartilage
https://www.readbyqxmd.com/read/28326407/instability-of-the-proximal-tibiofibular-joint-associated-with-total-knee-arthroplasty
#7
Martin Bédard, Simon Corriveau-Durand
To our knowledge, proximal tibiofibular joint instability has never been reported in a patient with a total knee arthroplasty (TKA). We present the case of a patient with anterolateral proximal tibiofibular joint instability associated with a complex primary TKA. In 2010, a male patient of 47 years was referred for TKA after posttraumatic osteoarthritis. The patient's history includes a fracture of the left lateral tibial plateau in 2008 and removal of osteosynthesis material in 2009. TKA with a lateral metal augment and intramedullary stem was performed in 2010...
September 2016: Arthroplasty Today
https://www.readbyqxmd.com/read/28249349/revision-of-total-knee-arthroplasties-performed-in-young-active-patients-with-posttraumatic-and-osteoarthritis
#8
Andrew Brian Old, William John Long, W Norman Scott
Rates of total knee arthroplasty (TKA) in younger patients are rising significantly. A recent study performed at our institute illustrated the excellent survivorship of TKAs in patients younger than 55 years at a mean follow-up period of 25 years. This study reports on the 25 knees in this series that required revision surgery. Twenty-five revisions were performed in 24 patients. Indication for revision, clinical outcomes, and radiographs were reviewed at their most recent follow-up. Revisions were performed in 5 cases of infection, 2 cases of fracture/trauma, 17 cases of wear/loosening, and 1 case of instability...
March 1, 2017: Journal of Knee Surgery
https://www.readbyqxmd.com/read/28224442/report-of-the-primary-outcomes-for-gait-mechanics-in-men-of-the-acl-sports-trial-secondary-prevention-with-and-without-perturbation-training-does-not-restore-gait-symmetry-in-men-1-or-2-years-after-acl-reconstruction
#9
Jacob John Capin, Ryan Zarzycki, Amelia Arundale, Kathleen Cummer, Lynn Snyder-Mackler
BACKGROUND: Movement asymmetries during walking are common after anterior cruciate ligament (ACL) injury and reconstruction and may influence the early development of posttraumatic osteoarthritis. Preoperative neuromuscular training (like perturbation training, which is neuromuscular training requiring selective muscle activation in response to surface perturbations) improves gait asymmetries and functional outcomes among people who are ACL-deficient, but the effect of postoperative perturbation training on gait mechanics after ACL reconstruction is unknown...
February 21, 2017: Clinical Orthopaedics and related Research
https://www.readbyqxmd.com/read/28146402/a-multicenter-study-of-early-anti-inflammatory-treatment-in-patients-with-acute-anterior-cruciate-ligament-tear
#10
Christian Lattermann, Cale A Jacobs, Mary Proffitt Bunnell, Laura J Huston, Lee G Gammon, Darren L Johnson, Emily K Reinke, Janet L Huebner, Virginia B Kraus, Kurt P Spindler
BACKGROUND: It is increasingly recognized that biochemical abnormalities of the joint precede radiographic abnormalities of posttraumatic osteoarthritis (PTOA) by as much as decades. A growing body of evidence strongly suggests that the progression from anterior cruciate ligament (ACL) injury to PTOA is multifactorial, involving the interplay between biomechanical disturbances and biochemical homeostasis of articular cartilage. PURPOSE: The purposes of this randomized study using an acute ACL injury model were to (1) evaluate the natural progression of inflammatory and chondrodegenerative biomarkers, (2) evaluate the relationship between subjective reports of pain and inflammatory and chondrodegenerative biomarkers, and (3) determine if postinjury arthrocentesis and corticosteroid injection offer the ability to alter this biochemical cascade...
February 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/28131634/comminuted-intraarticular-fractures-of-the-tibial-plateau-lead-to-posttraumatic-osteoarthritis-of-the-knee-current-treatment-review
#11
REVIEW
Matthias Aurich, Veit Koenig, Gunther Hofmann
Posttraumatic osteoarthritis (PTOA) of the knee is a common complication after intra- and extra-articular fractures. Moreover, PTOA may also be a result of isolated cartilage defects, meniscus resections, and ligament injuries. There are various methods of treatment of knee joint fractures. However, in the final stage of a PTOA, when nonoperative treatment fails, endoprosthetic joint replacement is the method of choice. Primary total knee replacement (TKR) for the treatment for a fracture of the knee joint is a rare indication, even at major treatment centers...
January 25, 2017: Asian Journal of Surgery
https://www.readbyqxmd.com/read/28091802/increased-risk-of-revision-reoperation-and-implant-constraint-in-tka-after-multiligament-knee-surgery
#12
Steven I Pancio, Paul L Sousa, Aaron J Krych, Matthew P Abdel, Bruce A Levy, Diane L Dahm, Michael J Stuart
BACKGROUND: The risk of major complications and revision arthroplasty after TKA in patients who previously underwent multiligament knee surgery have been poorly characterized. QUESTIONS/PURPOSES: Is multiligament knee surgery before TKA associated with (1) worse implant survival, (2) increased use of TKA design constraint, (3) a greater risk for major complications, and (4) poorer scores for pain and function compared with similar patients receiving TKA for primary osteoarthritis? METHODS: Fifty-nine TKAs were performed at our institution between 1985 and 2014 in 59 patients (36 men, 23 women; mean age, 53 years) with a history of previous multiligament knee surgery (≥ two ligaments)...
January 13, 2017: Clinical Orthopaedics and related Research
https://www.readbyqxmd.com/read/27881382/early-changes-in-knee-center-of-rotation-during-walking-after-anterior-cruciate-ligament-reconstruction-correlate-with-later-changes-in-patient-reported-outcomes
#13
Matthew R Titchenal, Constance R Chu, Jennifer C Erhart-Hledik, Thomas P Andriacchi
BACKGROUND: Altered knee kinematics after anterior cruciate ligament injury and reconstruction (ACLR) have been implicated in the development of posttraumatic osteoarthritis (PTOA), leading to poor long-term clinical outcomes. PURPOSE: This study was conducted to determine (1) whether the average knee center of rotation (KCOR), a multidimensional metric of knee kinematics, of the ACL-reconstructed knee during walking differs from that of the uninjured contralateral knee; (2) whether KCOR changes between 2 and 4 years after surgery; and (3) whether early KCOR changes predict patient-reported outcomes 8 years after ACLR...
March 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/27681622/suppression-of-nf-%C3%AE%C2%BAb-activity-via-nanoparticle-based-sirna-delivery-alters-early-cartilage-responses-to-injury
#14
Huimin Yan, Xin Duan, Hua Pan, Nilsson Holguin, Muhammad Farooq Rai, Antonina Akk, Luke E Springer, Samuel A Wickline, Linda J Sandell, Christine T N Pham
Osteoarthritis (OA) is a major cause of disability and morbidity in the aging population. Joint injury leads to cartilage damage, a known determinant for subsequent development of posttraumatic OA, which accounts for 12% of all OA. Understanding the early molecular and cellular responses postinjury may provide targets for therapeutic interventions that limit articular degeneration. Using a murine model of controlled knee joint impact injury that allows the examination of cartilage responses to injury at specific time points, we show that intraarticular delivery of a peptidic nanoparticle complexed to NF-κB siRNA significantly reduces early chondrocyte apoptosis and reactive synovitis...
October 11, 2016: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/27648746/does-anterior-cruciate-ligament-innervation-matter-for-joint-function-and-development-of-osteoarthritis
#15
Christopher V Nagelli, James L Cook, Kei Kuroki, Chantelle Bozynski, Richard Ma, Timothy E Hewett
Complications following anterior cruciate ligament (ACL) injury and reconstruction that include chronic dysfunction, second ACL injury, and posttraumatic osteoarthritis (OA) may be interrelated and stem from the inability to fully restore native ACL integrity and function. The loss of ACL sensory input following injury may significantly contribute to joint dysfunction. We developed a novel preclinical animal model to assess the contributions of ACL sensory afferents to knee joint function and health. We hypothesized that ACL sensory denervation would manifest in knee joint dysfunction and development of early OA...
September 20, 2016: Journal of Knee Surgery
https://www.readbyqxmd.com/read/27581178/we-need-to-implement-current-evidence-in-early-rehabilitation-programs-to-improve-long-term-outcome-after-anterior-cruciate-ligament-injury
#16
May Arna Risberg, Hege Grindem, Britt Elin Øiestad
We like to think that we are successful in the treatment of individuals with anterior cruciate ligament (ACL) injury, but recent literature reveals that only about 60% of these individuals make a full recovery, less than 60% return to sport, and more than 50% develop knee osteoarthritis (OA) by middle age. Both short- and long-term outcomes after ACL injury and reconstruction need attention and action. We need to implement strategies early after ACL injury to prevent the development and progression of posttraumatic OA, rather than "sit and wait" until posttraumatic knee OA has developed...
September 2016: Journal of Orthopaedic and Sports Physical Therapy
https://www.readbyqxmd.com/read/27522543/midterm-outcome-of-avon-patellofemoral-arthroplasty-for-posttraumatic-unicompartmental-osteoarthritis
#17
Sujith Konan, Fares S Haddad
BACKGROUND: Patellofemoral arthroplasties have been successfully used in the management of isolated patellofemoral joint (PFJ) osteoarthritis (OA). We hypothesized that in posttraumatic PFJ OA, isolated unicompartmental arthroplasty should be associated with reliable pain relief, patient satisfaction, and functional outcome at midterm follow-up. METHODS: Fifty-one Avon PFJ (Stryker, Mahwah, NJ) isolated unicompartmental arthroplasties (47 patients; 29 men, 18 women) were identified at a mean follow-up of 7...
July 13, 2016: Journal of Arthroplasty
https://www.readbyqxmd.com/read/27517056/a-surgical-model-of-posttraumatic-osteoarthritis-with-histological-and-gait-validation
#18
Talal Zahoor, Reed Mitchell, Priya Bhasin, Lew Schon, Zijun Zhang
BACKGROUND: Posttraumatic osteoarthritis (PTOA) is secondary to an array of joint injuries. Animal models are useful tools for addressing the uniqueness of PTOA progression in each type of joint injury and developing strategies for PTOA prevention and treatment. HYPOTHESIS: Intra-articular fracture induces PTOA pathology. STUDY DESIGN: Descriptive laboratory study. METHODS: Through a parapatellar incision, the medial tibial plateau was exposed in the left knees of 8 Sprague-Dawley rats...
July 2016: Orthopaedic Journal of Sports Medicine
https://www.readbyqxmd.com/read/27500994/shoulder-arthritis-secondary-to-rotator-cuff-tear-a-reproducible-murine-model-and-histopathologic-scoring-system
#19
Alissa Zingman, Hiayan Li, Leigh Sundem, Becca DeHority, Michael Geary, Theron Fussel, Robert Mooney, Michael Zuscik, John Elfar
Untreated rotator cuff tears can progress to a distinct form of shoulder arthritis, and the mechanism of this progression is poorly understood. Biomechanical, molecular and genetic factors may be at play, and a reliable animal model is needed to enable further research. The purpose of this study was to create a reproducible model of posttraumatic shoulder arthritis in the mouse, and to develop a scoring system for this model to enable future research on interventions, the role of various gene products, and the development of therapies to alter the natural course of the disease...
March 2017: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/27479834/extremity-war-injuries-x-return-to-health-and-function
#20
Col Jeffrey N Davila, Marc F Swiontkowski, Col Ret Romney C Andersen
The symposium Extremity War Injuries X: Return to Health and Function, presented by the American Academy of Orthopaedic Surgeons, the Orthopaedic Trauma Association, the Society of Military Orthopaedic Surgeons, and the Orthopaedic Research Society, was held in Washington, DC, on January 27 and 28, 2015. Course chairs Marc F. Swiontkowski, MD, and COL Jeffrey N. Davila, MD, presided over 2 days of general session lectures focusing on war/trauma-related musculoskeletal injuries resulting in service member disability, followed by small group discussions, with a goal of identifying knowledge gaps in the treatment of these injuries...
September 2016: Journal of the American Academy of Orthopaedic Surgeons
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