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Posttraumatic osteoarthritis AND knee

Huimin Yan, Xin Duan, Hua Pan, Nilsson Holguin, Muhammad Farooq Rai, Antonina Akk, Luke E Springer, Samuel A Wickline, Linda J Sandell, Christine T N Pham
Osteoarthritis (OA) is a major cause of disability and morbidity in the aging population. Joint injury leads to cartilage damage, a known determinant for subsequent development of posttraumatic OA, which accounts for 12% of all OA. Understanding the early molecular and cellular responses postinjury may provide targets for therapeutic interventions that limit articular degeneration. Using a murine model of controlled knee joint impact injury that allows the examination of cartilage responses to injury at specific time points, we show that intraarticular delivery of a peptidic nanoparticle complexed to NF-κB siRNA significantly reduces early chondrocyte apoptosis and reactive synovitis...
October 11, 2016: Proceedings of the National Academy of Sciences of the United States of America
Christopher V Nagelli, James L Cook, Kei Kuroki, Chantelle Bozynski, Richard Ma, Timothy E Hewett
Complications following anterior cruciate ligament (ACL) injury and reconstruction that include chronic dysfunction, second ACL injury, and posttraumatic osteoarthritis (OA) may be interrelated and stem from the inability to fully restore native ACL integrity and function. The loss of ACL sensory input following injury may significantly contribute to joint dysfunction. We developed a novel preclinical animal model to assess the contributions of ACL sensory afferents to knee joint function and health. We hypothesized that ACL sensory denervation would manifest in knee joint dysfunction and development of early OA...
September 20, 2016: Journal of Knee Surgery
May Arna Risberg, Hege Grindem, Britt Elin Øiestad
We like to think that we are successful in the treatment of individuals with anterior cruciate ligament (ACL) injury, but recent literature reveals that only about 60% of these individuals make a full recovery, less than 60% return to sport, and more than 50% develop knee osteoarthritis (OA) by middle age. Both short- and long-term outcomes after ACL injury and reconstruction need attention and action. We need to implement strategies early after ACL injury to prevent the development and progression of posttraumatic OA, rather than "sit and wait" until posttraumatic knee OA has developed...
September 2016: Journal of Orthopaedic and Sports Physical Therapy
Sujith Konan, Fares S Haddad
BACKGROUND: Patellofemoral arthroplasties have been successfully used in the management of isolated patellofemoral joint (PFJ) osteoarthritis (OA). We hypothesized that in posttraumatic PFJ OA, isolated unicompartmental arthroplasty should be associated with reliable pain relief, patient satisfaction, and functional outcome at midterm follow-up. METHODS: Fifty-one Avon PFJ (Stryker, Mahwah, NJ) isolated unicompartmental arthroplasties (47 patients; 29 men, 18 women) were identified at a mean follow-up of 7...
July 13, 2016: Journal of Arthroplasty
Talal Zahoor, Reed Mitchell, Priya Bhasin, Lew Schon, Zijun Zhang
BACKGROUND: Posttraumatic osteoarthritis (PTOA) is secondary to an array of joint injuries. Animal models are useful tools for addressing the uniqueness of PTOA progression in each type of joint injury and developing strategies for PTOA prevention and treatment. HYPOTHESIS: Intra-articular fracture induces PTOA pathology. STUDY DESIGN: Descriptive laboratory study. METHODS: Through a parapatellar incision, the medial tibial plateau was exposed in the left knees of 8 Sprague-Dawley rats...
July 2016: Orthopaedic Journal of Sports Medicine
Alissa Zingman, Hiayan Li, Leigh Sundem, Becca DeHority, Michael Geary, Theron Fussel, Robert Mooney, Michael Zuscik, John Elfar
Untreated rotator cuff tears can progress to a distinct form of shoulder arthritis, and the mechanism of this progression is poorly understood. Biomechanical, molecular and genetic factors may be at play, and a reliable animal model is needed to enable further research. The purpose of this study was to create a reproducible model of posttraumatic shoulder arthritis in the mouse, and to develop a scoring system for this model to enable future research on interventions, the role of various gene products, and the development of therapies to alter the natural course of the disease...
August 8, 2016: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
Col Jeffrey N Davila, Marc F Swiontkowski, Col Ret Romney C Andersen
The symposium Extremity War Injuries X: Return to Health and Function, presented by the American Academy of Orthopaedic Surgeons, the Orthopaedic Trauma Association, the Society of Military Orthopaedic Surgeons, and the Orthopaedic Research Society, was held in Washington, DC, on January 27 and 28, 2015. Course chairs Marc F. Swiontkowski, MD, and COL Jeffrey N. Davila, MD, presided over 2 days of general session lectures focusing on war/trauma-related musculoskeletal injuries resulting in service member disability, followed by small group discussions, with a goal of identifying knowledge gaps in the treatment of these injuries...
September 2016: Journal of the American Academy of Orthopaedic Surgeons
Jenna Le, Qi Peng, Karen Sperling
Osteoarthritis (OA) is a disease whose hallmark is the degeneration of articular cartilage. There is a worsening epidemic of OA in the United States today, with considerable economic costs. In order to develop more effective treatments for OA, noninvasive biomarkers that permit early diagnosis and treatment monitoring are necessary. T1rho and T2 mapping are two magnetic resonance imaging techniques that have shown great promise as noninvasive biomarkers of cartilage degeneration. Each of the two techniques is endowed with advantages and disadvantages: T1rho can discern earlier biochemical changes of OA than T2 mapping, while T2 mapping is more widely available and can be incorporated into existing imaging protocols in a more time-efficient manner than T1rho...
July 29, 2016: Annals of the New York Academy of Sciences
Minjie Zhang, Sriniwasan B Mani, Yao He, Amber M Hall, Lin Xu, Yefu Li, David Zurakowski, Gregory D Jay, Matthew L Warman
Joints that have degenerated as a result of aging or injury contain dead chondrocytes and damaged cartilage. Some studies have suggested that chondrocyte death precedes cartilage damage, but how the loss of chondrocytes affects cartilage integrity is not clear. In this study, we examined whether chondrocyte death undermines cartilage integrity in aging and injury using a rapid 3D confocal cartilage imaging technique coupled with standard histology. We induced autonomous expression of diphtheria toxin to kill articular surface chondrocytes in mice and determined that chondrocyte death did not lead to cartilage damage...
August 1, 2016: Journal of Clinical Investigation
T A Zharova, S V Ivannikov, A M Tonenkov, E Ph Stranadko, L A Semenova, M M Smorchkov, V I Makarov, I D Romanishkin, A V Ryabova, V B Loschenov
BACKGROUND: The new methods of osteoarthritis treatment are in constant demand due to the complexity of the early diagnosis and therapy. Specific features of Сhlorin e6 derivative (Ce6) accumulation in knee joint tissues and the efficiency of photodynamic therapy (PDT) of gonarthritis were studied. METHODS: The experimental research was conducted on the model of posttraumatic gonarthritis on rabbits. The analysis of dynamics of change of Ce6 concentration in tissues of a knee joint was carried out by the method of fluorescent diagnostics...
September 2016: Photodiagnosis and Photodynamic Therapy
Marco Bigoni, Marco Turati, Marta Gandolla, Paola Sacerdote, Massimiliano Piatti, Alberto Castelnuovo, Silvia Franchi, Massimo Gorla, Daniele Munegato, Diego Gaddi, Alessandra Pedrocchi, Robert J Omeljaniuk, Vittorio Locatelli, Antonio Torsello
Anterior cruciate ligament (ACL) reconstruction restores knee stability but does not reduce the incidence of posttraumatic osteoarthritis induced by inflammatory cytokines. The aim of this research was to longitudinally measure IL-1β, IL-6, IL-8, IL-10, and TNF-α levels in patients subjected to ACL reconstruction using bone-patellar tendon-bone graft. Synovial fluid was collected within 24-72 hours of ACL rupture (acute), 1 month after injury immediately prior to surgery (presurgery), and 1 month thereafter (postsurgery)...
2016: Mediators of Inflammation
Julian Dexel, Franziska Beyer, Cornelia Lützner, Christian Kleber, Jörg Lützner
The purpose of this study was to evaluate the surgical effort of total knee arthroplasty (TKA) for posttraumatic osteoarthritis (PTOA) compared with primary osteoarthritis (OA). A total of 1841 TKAs were analyzed, including 170 patients with PTOA, that resulted from soft tissue trauma in 83 patients and fractures in 87 patients. Results showed that patients were significantly younger at the time of surgery in the posttraumatic group (62 vs 71 years; P<.001). Furthermore, fracture was associated with 3.7 years earlier need of TKA compared with soft tissue trauma...
May 2016: Orthopedics
James E Showery, Nicholas A Kusnezov, John C Dunn, Julia O Bader, Philip J Belmont, Brian R Waterman
BACKGROUND: This investigation sought to quantify incidence rates (IRs) and risk factors for primary and secondary (ie, posttraumatic) osteoarthritis (OA) of the knee in an active military population. METHODS: We performed a retrospective review of United States military active duty servicemembers with first-time diagnosis of primary (International Classification of Disease, 9th Edition code: 715.16) and secondary (International Classification of Disease, 9th Edition code: 715...
October 2016: Journal of Arthroplasty
Andrew S Murtha, Anthony E Johnson, Joseph A Buckwalter, Jessica C Rivera
United States military personnel frequently suffer knee injuries. The resulting progressive post-traumatic osteoarthritis (PTOA) causes significant disability in these young high-demand patients for which total knee arthroplasty (TKA) is the only effective treatment of their pain and impairment. Yet the use of this option for treatment of PTOA has not been studied. This retrospective review identified 74 knees in 64 U.S. military personnel who underwent TKA at ≤ 50 years-of-age during an eight year period at a tertiary-care, academic, military medical center...
May 13, 2016: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
Matthew R Akelman, Paul D Fadale, Michael J Hulstyn, Robert M Shalvoy, Arlene Garcia, Kaitlyn E Chin, Jeffrey Duryea, Gary J Badger, Glenn A Tung, Braden C Fleming
BACKGROUND: The "initial graft tension" applied at the time of graft fixation during anterior cruciate ligament (ACL) reconstruction surgery modulates joint contact mechanics, which in turn may promote posttraumatic osteoarthritis (OA). PURPOSE/HYPOTHESES: The study objectives were to compare clinical, functional, patient-reported, and OA imaging outcomes between 2 different initial laxity-based graft tension cohorts and a matched uninjured control group as well as to evaluate the effects of laxity-based graft tension on OA development at 84-month follow-up...
July 2016: American Journal of Sports Medicine
Ata M Kiapour, Constantine K Demetropoulos, Ali Kiapour, Carmen E Quatman, Samuel C Wordeman, Vijay K Goel, Timothy E Hewett
BACKGROUND: Despite basic characterization of the loading factors that strain the anterior cruciate ligament (ACL), the interrelationship(s) and additive nature of these loads that occur during noncontact ACL injuries remain incompletely characterized. HYPOTHESIS: In the presence of an impulsive axial compression, simulating vertical ground-reaction force during landing (1) both knee abduction and internal tibial rotation moments would result in increased peak ACL strain, and (2) a combined multiplanar loading condition, including both knee abduction and internal tibial rotation moments, would increase the peak ACL strain to levels greater than those under uniplanar loading modes alone...
August 2016: American Journal of Sports Medicine
Brian G Pietrosimone, J Troy Blackburn, Yvonne M Golightly, Matthew S Harkey, Brittney A Luc, J D DeFreese, Darin A Padua, Joanne M Jordan, Kim L Bennell
CONTEXT:  Posttraumatic osteoarthritis (PTOA) is a specific phenotype of osteoarthritis (OA) that commonly develops after acute knee injury, such as anterior cruciate ligament (ACL) or meniscal injury (or both). Athletic trainers (ATs) are well positioned to educate patients and begin PTOA management during rehabilitation of the acute injury, yet it remains unknown if ATs currently prioritize long-term outcomes in patients with knee injury. OBJECTIVE:  To investigate ATs' knowledge and perceptions of OA and its treatment after ACL injury, ACL reconstruction, or meniscal injury or surgery...
May 4, 2016: Journal of Athletic Training
Abbey C Thomas, Tricia Hubbard-Turner, Erik A Wikstrom, Riann M Palmieri-Smith
Osteoarthritis is a leading cause of disability whose prevalence and incidence continue to increase. History of joint injury represents an important risk factor for posttraumatic osteoarthritis and is a significant contributor to the rapidly growing percentage of the population with osteoarthritis. This review will present the epidemiology associated with posttraumatic osteoarthritis, with particular emphasis on the knee and ankle joints. It is important to understand the effect of posttraumatic osteoarthritis on the population so that sufficient resources can be devoted to countering the disease and promoting optimal long-term health for patients after joint injury...
May 4, 2016: Journal of Athletic Training
Benjamin S Kester, Shobhit V Minhas, Jonathan M Vigdorchik, Ran Schwarzkopf
BACKGROUND: Total knee arthroplasty (TKA) is often the best answer for end-stage, posttraumatic osteoarthritis after intra-articular and periarticular fractures about the knee. Although TKA in this setting is often considered more technically demanding, outcomes are typically worse for patients. This study examines the intraoperative differences and 30-day outcomes in posttraumatic vs primary TKA cohorts. METHODS: Patients undergoing TKA were selected from the National Surgical Quality Improvement Program database from 2010 to 2013...
August 2016: Journal of Arthroplasty
Guoqing Du, Hongsheng Zhan, Daofang Ding, Shaowei Wang, Xiaochun Wei, Fangyuan Wei, Jianzhong Zhang, Bahar Bilgen, Anthony M Reginato, Braden C Fleming, Jin Deng, Lei Wei
BACKGROUND: Although patients with an anterior cruciate ligament (ACL) injury have a high risk of developing posttraumatic osteoarthritis (PTOA), the role of meniscus hypertrophy and mineralization in PTOA after an ACL injury remains unknown. PURPOSE/HYPOTHESIS: The purpose of this study was to determine if menisci respond to abnormal loading and if an ACL injury results in meniscus hypertrophy and calcification. The hypotheses were that (1) abnormal mechanical loading after an ACL injury induces meniscus hypertrophy and mineralization, which correlates to articular cartilage damage in vivo, and (2) abnormal mechanical loading on bovine meniscus explants induces the overexpression of hypertrophic and mineralization markers in vitro...
March 2016: American Journal of Sports Medicine
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