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Posttraumatic osteoarthritis

Huimin Yan, Xin Duan, Hua Pan, Nilsson Holguin, Muhammad Farooq Rai, Antonina Akk, Luke E Springer, Samuel A Wickline, Linda J Sandell, Christine T N Pham
Osteoarthritis (OA) is a major cause of disability and morbidity in the aging population. Joint injury leads to cartilage damage, a known determinant for subsequent development of posttraumatic OA, which accounts for 12% of all OA. Understanding the early molecular and cellular responses postinjury may provide targets for therapeutic interventions that limit articular degeneration. Using a murine model of controlled knee joint impact injury that allows the examination of cartilage responses to injury at specific time points, we show that intraarticular delivery of a peptidic nanoparticle complexed to NF-κB siRNA significantly reduces early chondrocyte apoptosis and reactive synovitis...
October 11, 2016: Proceedings of the National Academy of Sciences of the United States of America
Ewout S Veltman, Ernst Ja Steller, Philippe Wittich, Jort Keizer
A case of complicated lateral subtalar dislocation is presented and the literature concerning this injury is reviewed. Subtalar joint dislocations are rare and often the result of a high-energy trauma. Complications include avascular necrosis of the talus, infection, posttraumatic osteoarthritis requiring arthrodesis and chronic subtalar instability. Negative prognostic factors include lateral and complicated dislocations, total talar extrusions, and associated fractures. A literature search was performed to identify studies describing outcome after lateral subtalar joint dislocation...
September 18, 2016: World Journal of Orthopedics
Christopher V Nagelli, James L Cook, Kei Kuroki, Chantelle Bozynski, Richard Ma, Timothy E Hewett
Complications following anterior cruciate ligament (ACL) injury and reconstruction that include chronic dysfunction, second ACL injury, and posttraumatic osteoarthritis (OA) may be interrelated and stem from the inability to fully restore native ACL integrity and function. The loss of ACL sensory input following injury may significantly contribute to joint dysfunction. We developed a novel preclinical animal model to assess the contributions of ACL sensory afferents to knee joint function and health. We hypothesized that ACL sensory denervation would manifest in knee joint dysfunction and development of early OA...
September 20, 2016: Journal of Knee Surgery
J He, Y Jiang, P G Alexander, V Ulici, Y Zhu, S Wu, R S Tuan
OBJECTIVES: The infrapatellar fat pad (IPFP), which is located underneath the patella, close to cartilage surfaces, functions in distributing mechanical load and has been shown to produce cytokines. This study aims to assess the involvement of the IPFP in the progression of post-traumatic osteoarthritis (OA) through investigating the crosstalk between the IPFP and injured cartilage in vitro. METHODS: A single blunt impact (36 MPa) on healthy bovine articular cartilage explants was used to generate traumatized cartilage...
September 9, 2016: Osteoarthritis and Cartilage
May Arna Risberg, Hege Grindem, Britt Elin Øiestad
We like to think that we are successful in the treatment of individuals with anterior cruciate ligament (ACL) injury, but recent literature reveals that only about 60% of these individuals make a full recovery, less than 60% return to sport, and more than 50% develop knee osteoarthritis (OA) by middle age. Both short- and long-term outcomes after ACL injury and reconstruction need attention and action. We need to implement strategies early after ACL injury to prevent the development and progression of posttraumatic OA, rather than "sit and wait" until posttraumatic knee OA has developed...
September 2016: Journal of Orthopaedic and Sports Physical Therapy
J Gülke, M Mentzel, D Dornacher, L Schneider, T Kapapa, N J Wachter
BACKGROUND/PURPOSE: Joint replacement is a widely used procedure to treat painful osteoarthritis of the proximal interphalangeal joint. From 1996 to 1999, 16 patients received 19 hinged, piston-based DIGITOS prostheses in our department. In 2007, the 7-year clinical course of 14 patients (17 devices) was published in this journal. Now 12 of these patients (15 devices) have been followed with an average history of 17 years, and the preoperative data has been compared with the results after 7 and 17 years, respectively...
August 2016: Handchirurgie, Mikrochirurgie, Plastische Chirurgie
Ji-Cheng Gong, Bing-Hua Zhou, Xu Tao, Cheng-Song Yuan, Kang-Lai Tang
BACKGROUND: Tibiotalocalcaneal arthrodesis with headless compression screws has not been previously reported. We hypothesized that these screws could be suitable for tibiotalocalcaneal arthrodesis because of their special design. This study aimed to evaluate the clinical outcomes of patients undergoing tibiotalocalcaneal arthrodesis with headless compression screws for the treatment of severe arthropathy of the ankle and subtalar joint. METHODS: From 2010 to 2015, 23 patients with severe ankle and subtalar arthropathy underwent tibiotalocalcaneal arthrodesis...
2016: Journal of Orthopaedic Surgery and Research
Khaled A Elsaid, Anand Ubhe, Ziyad Shaman, Gerard D'Souza
BACKGROUND: Interleukin-1 receptor antagonist (IL-1 ra) can be disease-modifying in posttraumatic osteoarthritis (PTOA). One limitation is its short joint residence time. We hypothesized that IL-1 ra encapsulation in poly (lactide-co-glycolide) (PLGA) microspheres reduces IL-1 ra systemic absorption and provides an enhanced anti-PTOA effect. METHODS: IL-1 ra release kinetics and biological activity: IL-1 ra encapsulation into PLGA microsphere was performed using double emulsion solvent extraction...
December 2016: Journal of Experimental Orthopaedics
Sujith Konan, Fares S Haddad
BACKGROUND: Patellofemoral arthroplasties have been successfully used in the management of isolated patellofemoral joint (PFJ) osteoarthritis (OA). We hypothesized that in posttraumatic PFJ OA, isolated unicompartmental arthroplasty should be associated with reliable pain relief, patient satisfaction, and functional outcome at midterm follow-up. METHODS: Fifty-one Avon PFJ (Stryker, Mahwah, NJ) isolated unicompartmental arthroplasties (47 patients; 29 men, 18 women) were identified at a mean follow-up of 7...
July 13, 2016: Journal of Arthroplasty
Talal Zahoor, Reed Mitchell, Priya Bhasin, Lew Schon, Zijun Zhang
BACKGROUND: Posttraumatic osteoarthritis (PTOA) is secondary to an array of joint injuries. Animal models are useful tools for addressing the uniqueness of PTOA progression in each type of joint injury and developing strategies for PTOA prevention and treatment. HYPOTHESIS: Intra-articular fracture induces PTOA pathology. STUDY DESIGN: Descriptive laboratory study. METHODS: Through a parapatellar incision, the medial tibial plateau was exposed in the left knees of 8 Sprague-Dawley rats...
July 2016: Orthopaedic Journal of Sports Medicine
Alissa Zingman, Hiayan Li, Leigh Sundem, Becca DeHority, Michael Geary, Theron Fussel, Robert Mooney, Michael Zuscik, John Elfar
Untreated rotator cuff tears can progress to a distinct form of shoulder arthritis, and the mechanism of this progression is poorly understood. Biomechanical, molecular and genetic factors may be at play, and a reliable animal model is needed to enable further research. The purpose of this study was to create a reproducible model of posttraumatic shoulder arthritis in the mouse, and to develop a scoring system for this model to enable future research on interventions, the role of various gene products, and the development of therapies to alter the natural course of the disease...
August 8, 2016: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
Jason D Gibson, Michael B O'Sullivan, Farhang Alaee, David N Paglia, Ryu Yoshida, Rosa M Guzzo, Hicham Drissi
: : The success of cell-based therapies to restore joint cartilage requires an optimal source of reparative progenitor cells and tight control of their differentiation into a permanent cartilage phenotype. Bone morphogenetic protein 2 (BMP-2) has been extensively shown to promote mesenchymal cell differentiation into chondrocytes in vitro and in vivo. Conversely, developmental studies have demonstrated decreased chondrocyte maturation by Wingless-Type MMTV Integration Site Family, Member 5A (Wnt5a)...
August 5, 2016: Stem Cells Translational Medicine
Col Jeffrey N Davila, Marc F Swiontkowski, Col Ret Romney C Andersen
The symposium Extremity War Injuries X: Return to Health and Function, presented by the American Academy of Orthopaedic Surgeons, the Orthopaedic Trauma Association, the Society of Military Orthopaedic Surgeons, and the Orthopaedic Research Society, was held in Washington, DC, on January 27 and 28, 2015. Course chairs Marc F. Swiontkowski, MD, and COL Jeffrey N. Davila, MD, presided over 2 days of general session lectures focusing on war/trauma-related musculoskeletal injuries resulting in service member disability, followed by small group discussions, with a goal of identifying knowledge gaps in the treatment of these injuries...
September 2016: Journal of the American Academy of Orthopaedic Surgeons
Jenna Le, Qi Peng, Karen Sperling
Osteoarthritis (OA) is a disease whose hallmark is the degeneration of articular cartilage. There is a worsening epidemic of OA in the United States today, with considerable economic costs. In order to develop more effective treatments for OA, noninvasive biomarkers that permit early diagnosis and treatment monitoring are necessary. T1rho and T2 mapping are two magnetic resonance imaging techniques that have shown great promise as noninvasive biomarkers of cartilage degeneration. Each of the two techniques is endowed with advantages and disadvantages: T1rho can discern earlier biochemical changes of OA than T2 mapping, while T2 mapping is more widely available and can be incorporated into existing imaging protocols in a more time-efficient manner than T1rho...
July 29, 2016: Annals of the New York Academy of Sciences
Minjie Zhang, Sriniwasan B Mani, Yao He, Amber M Hall, Lin Xu, Yefu Li, David Zurakowski, Gregory D Jay, Matthew L Warman
Joints that have degenerated as a result of aging or injury contain dead chondrocytes and damaged cartilage. Some studies have suggested that chondrocyte death precedes cartilage damage, but how the loss of chondrocytes affects cartilage integrity is not clear. In this study, we examined whether chondrocyte death undermines cartilage integrity in aging and injury using a rapid 3D confocal cartilage imaging technique coupled with standard histology. We induced autonomous expression of diphtheria toxin to kill articular surface chondrocytes in mice and determined that chondrocyte death did not lead to cartilage damage...
August 1, 2016: Journal of Clinical Investigation
Hernekamp Jochen-Frederick, Yary Pouyan, Bigdeli Amir Khosrow, Hirche Christoph, Bickert Berthold, Kneser Ulrich, Kremer Thomas
BACKGROUND AND AIM: Resection of the ulnar head (Darrach procedure) is still frequently performed in patients suffering from posttraumatic osteoarthritis of the distal radioulnar joint (DRUJ). Ulnar impingement syndrome is sometimes observed with subsequent poor functional outcome. Here, we present a long-term follow-up study after Darrach procedure to evaluate functional results, pain relief, and patient satisfaction. METHODS: Thirty-seven patients after ulnar head resection who were treated in our clinic between 2006 and 2012 were invited for follow-up investigation...
October 2016: Journal of Plastic, Reconstructive & Aesthetic Surgery: JPRAS
T A Zharova, S V Ivannikov, A M Tonenkov, E Ph Stranadko, L A Semenova, M M Smorchkov, V I Makarov, I D Romanishkin, A V Ryabova, V B Loschenov
BACKGROUND: The new methods of osteoarthritis treatment are in constant demand due to the complexity of the early diagnosis and therapy. Specific features of Сhlorin e6 derivative (Ce6) accumulation in knee joint tissues and the efficiency of photodynamic therapy (PDT) of gonarthritis were studied. METHODS: The experimental research was conducted on the model of posttraumatic gonarthritis on rabbits. The analysis of dynamics of change of Ce6 concentration in tissues of a knee joint was carried out by the method of fluorescent diagnostics...
September 2016: Photodiagnosis and Photodynamic Therapy
Marco Bigoni, Marco Turati, Marta Gandolla, Paola Sacerdote, Massimiliano Piatti, Alberto Castelnuovo, Silvia Franchi, Massimo Gorla, Daniele Munegato, Diego Gaddi, Alessandra Pedrocchi, Robert J Omeljaniuk, Vittorio Locatelli, Antonio Torsello
Anterior cruciate ligament (ACL) reconstruction restores knee stability but does not reduce the incidence of posttraumatic osteoarthritis induced by inflammatory cytokines. The aim of this research was to longitudinally measure IL-1β, IL-6, IL-8, IL-10, and TNF-α levels in patients subjected to ACL reconstruction using bone-patellar tendon-bone graft. Synovial fluid was collected within 24-72 hours of ACL rupture (acute), 1 month after injury immediately prior to surgery (presurgery), and 1 month thereafter (postsurgery)...
2016: Mediators of Inflammation
Christian Lattermann, Cale A Jacobs, Mary Proffitt Bunnell, Kate Jochimsen, John Abt, Emily K Reinke, Lee Gammon, Janet L Huebner, Virginia B Kraus, Kurt P Spindler
Anterior cruciate ligament (ACL) injuries are common and lead to posttraumatic osteoarthritis (PTOA) in a high percentage of patients. Research has been ineffective in identifying successful treatment options for people suffering from symptomatic PTOA resulting in a shift of focus towards the young, ACL injured patients at risk of developing PTOA. Randomized clinical trials examining the very early phase after ACL injury are ideal to study this population; however, these trials face significant challenges regarding recruitment as well as reproducibility of patient-reported outcomes (PROs) and inflammatory and/or chondrodegenerative biomarkers associated with early PTOA...
June 9, 2016: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
Julian Dexel, Franziska Beyer, Cornelia Lützner, Christian Kleber, Jörg Lützner
The purpose of this study was to evaluate the surgical effort of total knee arthroplasty (TKA) for posttraumatic osteoarthritis (PTOA) compared with primary osteoarthritis (OA). A total of 1841 TKAs were analyzed, including 170 patients with PTOA, that resulted from soft tissue trauma in 83 patients and fractures in 87 patients. Results showed that patients were significantly younger at the time of surgery in the posttraumatic group (62 vs 71 years; P<.001). Furthermore, fracture was associated with 3.7 years earlier need of TKA compared with soft tissue trauma...
May 2016: Orthopedics
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