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Posttraumatic osteoarthritis

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https://www.readbyqxmd.com/read/29773451/total-hip-arthroplasty-for-posttraumatic-osteoarthritis-following-acetabular-fracture-a-systematic-review-of-characteristics-outcomes-and-complications
#1
Robert D Stibolt, Harshadkumar A Patel, Samuel R Huntley, Eva J Lehtonen, Ashish B Shah, Sameer M Naranje
PURPOSE: Posttraumatic arthritis (PTA) may develop years after acetabular fracture, hindering joint function and causing significant chronic musculoskeletal pain. Given the delayed onset of PTA, few studies have assessed outcomes of delayed total hip arthroplasty (THA) in acetabular fracture patients. This study systematically reviewed the literature for outcomes of THA in patients with PTA and prior acetabular fracture. METHODS: Pubmed, EMBASE, SCOPUS, and Cochrane library were searched for articles containing the keywords "acetabular", "fracture", "arthroplasty", and "post traumatic arthritis" published between 1995 and August 2017...
April 26, 2018: Chinese Journal of Traumatology, Zhonghua Chuang Shang za Zhi
https://www.readbyqxmd.com/read/29752537/when-and-how-to-operate-the-posterior-malleolus-fragment-in-trimalleolar-fractures-a-systematic-literature-review
#2
Samuel Marinus Verhage, Jochem Maarten Hoogendoorn, Pieta Krijnen, Inger Birgitta Schipper
OBJECTIVES: Whether or not and how to fixate the posterior malleolus fracture seems to depend on the fracture fragment size and its amount of dislocation, but clear guidelines for daily practice are lacking. In this review, we summarize the literature on preferred treatment of the posterior fragment in trimalleolar fractures. METHODS: A systematic review of publications between January 1995 and April 30 2017 on this topic in the PubMed, Embase, and Cochrane databases was performed according to the PRISMA statement...
May 12, 2018: Archives of Orthopaedic and Trauma Surgery
https://www.readbyqxmd.com/read/29749312/aav-mediated-overexpression-of-il-10-mitigates-the-inflammatory-cascade-in-stimulated-equine-chondrocyte-pellets
#3
Kyla Ortved, Laila Begum, Darko Stefanovski, Alan Nixon
BACKGROUND: following joint trauma, a post-traumatic inflammatory cascade drives degeneration of the joint. We aimed to assess whether transduction of chondrocytes with AAV5 overexpressing the immunomodulatory cytokine IL-10 would have protective effects in pellet cultures stimulated with IL-1β. METHODS: Chondrocytes were isolated from 3 healthy horses and were transduced with AAV5-IL-10 at a dose of 1 x 105vg/cell. Chondrocyte pellets were formed by centrifugation and were stimulated with IL-1β starting 48 hours following transduction...
May 10, 2018: Current Gene Therapy
https://www.readbyqxmd.com/read/29736569/osteoarthritis-trauma-vs-disease
#4
Gema Jiménez, Jesús Cobo-Molinos, Cristina Antich, Elena López-Ruiz
Osteoarthritis (OA) is the most prevalent joint disease characterized by pain and degenerative lesions of the cartilage, subchondral bone, and other joint tissues. The causes of OA remain incompletely understood. Over the years, it has become recognized that OA is a multifactorial disease. In particular, aging and trauma are the main risk factors identified for the development of OA; however, other factors such as genetic predisposition, obesity, inflammation, gender and hormones, or metabolic syndrome contribute to OA development and lead to a more severe outcome...
2018: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29678170/self-reported-functional-recovery-after-reconstruction-versus-repair-in-acute-anterior-cruciate-ligament-rupture-rotor-a-randomized-controlled-clinical-trial
#5
Barbara C Boer, Roy A G Hoogeslag, Reinoud W Brouwer, Anna Demmer, Rianne M H A Huis In 't Veld
BACKGROUND: Anterior cruciate ligament (ACL) reconstruction is today's surgical gold standard for ACL rupture. Although it provides satisfactory results, not all patients return to their previous activity level and moreover, early posttraumatic osteoarthritis is not prevented. As such, a renewed interest has emerged in ACL suture repair combined with dynamic augmentation. Compared to ACL reconstruction, the hypothesized advantages of ACL suture repair are earlier return to sports, reduction of early posttraumatic osteoarthritis and preservation of the patient's native ACL tissue and proprioceptive envelope of the knee...
April 20, 2018: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/29668309/posttraumatic-osteoarthritis-development-and-progression-in-an-ovine-model-of-partial-anterior-cruciate-ligament-transection-and-effect-of-repeated-intra-articular-methylprednisolone-acetate-injections-on-early-disease
#6
Kristen I Barton, Bryan J Heard, Johnathan L Sevick, C Ryan Martin, S M Mehdi Shekarforoush, May Chung, Yamini Achari, Cyril B Frank, Nigel G Shrive, David A Hart
BACKGROUND: Partial anterior cruciate ligament (p-ACL) ruptures are a common injury of athletes. However, few preclinical models have investigated the natural history and treatment of p-ACL injuries. PURPOSE: To (1) demonstrate whether a controlled p-ACL injury model (anteromedial band transection) develops progressive gross morphological and histological posttraumatic osteoarthritis (PTOA)-like changes at 20 and 40 weeks after the injury and (2) investigate the efficacy of repeated (0, 5, 10, and 15 weeks) intra-articular injections of methylprednisolone acetate (MPA; 80 mg/mL) in the mitigation of potential PTOA-like changes after p-ACL transection...
April 1, 2018: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/29667844/lower-extremity-biomechanics-during-a-drop-vertical-jump-in-participants-with-or-without-chronic-ankle-instability
#7
C Collin Herb, Kaitlyn Grossman, Mark A Feger, Luke Donovan, Jay Hertel
CONTEXT:   Chronic ankle instability (CAI) is a condition characterized by range-of-motion, neuromuscular, and postural-control deficits and subjective disability, reinjury, and posttraumatic osteoarthritis. Differences have been reported in kinematics, kinetics, surface electromyography (EMG), and ground reaction forces during functional tasks performed by those with CAI. These measures are often collected independently, and the research on collecting measures simultaneously during a movement task is limited...
April 18, 2018: Journal of Athletic Training
https://www.readbyqxmd.com/read/29665605/-shoulder-arthroplasty
#8
Anna Krukenberg, Jan-Philipp Imiolczyk, Philipp Moroder, Markus Scheibel
Shoulder arthroplasty has been performed increasingly during the last years. The concept of modern anatomic shoulder arthroplasty is based on C. S. Neer's first shoulder prosthesis in the 1950s which was originally designed for the treatment of fractures of the proximal humerus. Since then, this monoblock prosthesis has undergone many changes and improvements. By now, an anatomic reconstruction of the joint is possible. Hence, the indications for anatomic shoulder arthroplasty have been added amongst others by osteoarthritis, necrosis, rheumatoid arthritis or posttraumatic arthritis...
April 2018: Zeitschrift Für Orthopädie und Unfallchirurgie
https://www.readbyqxmd.com/read/29629916/distal-femoral-varus-osteotomy-for-the-management-of-valgus-deformity-of-the-knee
#9
Seth L Sherman, Samuel F Thompson, John C F Clohisy
Distal femoral varus osteotomy is a well-described treatment option for patients with valgus malalignment associated with a variety of underlying conditions. This procedure may be the definitive treatment option in active patients with isolated lateral compartment osteoarthritis or posttraumatic arthritis. It may be a useful concomitant procedure in young patients with lateral meniscus deficiency, focal chondral defects, chronic medial collateral ligament insufficiency, and/or patellofemoral instability. Distal femoral varus osteotomy can be performed with medial closing wedge or lateral opening wedge techniques...
May 1, 2018: Journal of the American Academy of Orthopaedic Surgeons
https://www.readbyqxmd.com/read/29621984/management-of-isolated-coronal-shear-fractures-of-the-humeral-capitellum-with-herbert-screw-fixation-through-anterolateral-approach
#10
Tengbo Yu, Hao Tao, Fenglei Xu, Yanling Hu, Chengdong Zhang, Guangjie Zhou
BACKGROUND: Due to the intraarticular and complex nature of the coronal shear fracture of the humeral capitellum and its rarity, it has been difficult to formulate a universally accepted method of surgical management. The purpose of this study is to retrospectively evaluate the clinical outcomes of 15 patients with isolated coronal shear fractures of the capitellum treated by Herbert screw fixation through anterolateral approach, and to address the safety and tips for this surgical procedure...
April 5, 2018: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/29608139/senescent-cells-and-osteoarthritis-a-painful-connection
#11
Ok Hee Jeon, Nathaniel David, Judith Campisi, Jennifer H Elisseeff
Senescent cells (SnCs) are associated with age-related pathologies. Osteoarthritis is a chronic disease characterized by pain, loss of cartilage, and joint inflammation, and its incidence increases with age. For years, the presence of SnCs in cartilage isolated from patients undergoing total knee artificial implants has been noted, but these cells' relevance to disease was unclear. In this Review, we summarize current knowledge of SnCs in the multiple tissues that constitute the articular joint. New evidence for the causative role of SnCs in the development of posttraumatic and age-related arthritis is reviewed along with the therapeutic benefit of SnC clearance...
April 2, 2018: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/29576918/nonspanning-total-wrist-arthrodesis-with-a-low-profile-locking-plate
#12
Schneider K Rancy, Eugene T Ek, Sophia Paul, Robert N Hotchkiss, Scott W Wolfe
Purpose  This study aims to compare the outcomes and complications of our technique for nonspanning total wrist arthrodesis using a locking plate with the standard carpometacarpal spanning technique. Methods  A retrospective review of charts was performed to identify patients who underwent total wrist arthrodesis by the senior author (S.W.W.). We compared the outcomes of 15 cases of nonspanning wrist fusion with a 2.4/2.7 mm locking T plate to 11 cases of spanning wrist fusion with a 2.7/3.5 mm locking compression plate...
April 2018: Journal of Wrist Surgery
https://www.readbyqxmd.com/read/29529627/no-benefit-of-computer-assisted-tka-10-year-results-of-a-prospective-randomized-study
#13
Matthieu Ollivier, Sébastien Parratte, Ludovic Lino, Xavier Flecher, Sébastien Pesenti, Jean-Noël Argenson
BACKGROUND: Previously published studies reported benefits of computer-assisted surgery (CAS) in terms of radiographic implant position in TKA, but whether these improvements result in clinically important survival differences or functional differences that a patient might perceive at a minimum 10-year followup remains largely unknown. QUESTIONS/PURPOSES: We performed a prospective randomized trial and asked whether CAS (1) improved survival free from aseptic loosening; and (2) demonstrated any clear difference in patient-reported outcomes at latest followup using validated outcome measures at minimum 10-year followup...
January 2018: Clinical Orthopaedics and related Research
https://www.readbyqxmd.com/read/29511786/-anatomical-total-shoulder-replacement-in-glenohumeral-osteoarthritis-indications-current-implants-and-clinical-results
#14
REVIEW
O Lorbach
IMPLANT DESIGNS: Within the last 50 years, implants for shoulder replacement have developed rapidly. Monobloc-stems in few sizes were changed to modular implant systems that allow for an individual adaption of the stem, as well as adaption of the humeral head component according to the specific anatomic situation of the patient. Moreover, stemless und short stem implants are available, which may highly simplify primary implantation, especially in posttraumatic cases as well as in revision cases with a need for removal or change of the implants...
May 2018: Der Orthopäde
https://www.readbyqxmd.com/read/29499818/articular-incongruity-in-the-lower-extremity-how-much-is-too-much
#15
REVIEW
Tim R Beals, Robert Harris, Darryl A Auston
Intraarticular fractures carry a significant risk for posttraumatic osteoarthritis, and this risk varies across different joint surfaces of the lower extremity. These differences are likely due to the anatomic and biomechanical specifics of each joint surface. High-quality human studies are lacking to delineate the threshold articular incongruity that significantly increases risk for posttraumatic osteoarthritis and diminished clinical outcomes for many joint surfaces. Even with anatomic reduction of the articular surface, close attention must be paid to mechanical axis and joint stability to optimize outcomes...
April 2018: Orthopedic Clinics of North America
https://www.readbyqxmd.com/read/29469223/mitoprotective-therapy-preserves-chondrocyte-viability-and-prevents-cartilage-degeneration-in-an-ex-vivo-model-of-posttraumatic-osteoarthritis
#16
Michelle L Delco, Edward D Bonnevie, Hazel S Szeto, Lawrence J Bonassar, Lisa A Fortier
No disease-modifying osteoarthritis (OA) drugs are available to prevent posttraumatic osteoarthritis (PTOA). Mitochondria (MT) mediate the pathogenesis of many degenerative diseases, and recent evidence indicates that MT dysfunction is a peracute (within minutes to hours) response of cartilage to mechanical injury. The goal of this study was to investigate cardiolipin-targeted mitoprotection as a new strategy to prevent chondrocyte death and cartilage degeneration after injury. Cartilage was harvested from bovine knee joints and subjected to a single, rapid impact injury (24...
February 22, 2018: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/29461394/diagnosis-and-management-of-polytraumatized-patients-with-severe-extremity-trauma
#17
Todd O McKinley, Greg E Gaski, Yoram Vodovotz, Benjamin T Corona, Timothy R Billiar
Multiply injured patients with severe extremity trauma are at risk of acute systemic complications and are at high risk of developing longer term orthopaedic complications including soft-tissue infection, osteomyelitis, posttraumatic osteoarthritis, and nonunion. It is becoming increasingly recognized that injury magnitude and response to injury have major jurisdiction pertaining to patient outcomes and complications. The complexities of injury and injury response that affect outcomes present opportunities to apply precision approaches to understand and quantify injury magnitude and injury response on a patient-specific basis...
March 2018: Journal of Orthopaedic Trauma
https://www.readbyqxmd.com/read/29456776/what-percentage-of-patients-is-a-candidate-for-unicompartmental-knee-replacement-at-a-chinese-arthroplasty-center
#18
Yong He, Lianbo Xiao, Weitao Zhai, Maximilian F Kasparek, Guilin Ouyang, Friedrich Boettner
Background: Data on indication of Unicompartmental Knee Arthroplasty (UKA) in the Asian population are currently not available. The current paper evaluates patients undergoing knee replacement at a Chinese Orthopaedic Specialty Hospital to report the percentage of patients who meet radiographic and clinical indication criteria for UKA. Methods: Over a one-year period 463 consecutive patients (515 knees) underwent primary knee replacement surgery. Clinical data were recorded and preoperative radiographs were assessed...
2018: Open Orthopaedics Journal
https://www.readbyqxmd.com/read/29437147/targeting-mitochondrial-responses-to-intra-articular-fracture-to-prevent-posttraumatic-osteoarthritis
#19
Mitchell C Coleman, Jessica E Goetz, Marc J Brouillette, Dongrim Seol, Michael C Willey, Emily B Petersen, Hope D Anderson, Nathan R Hendrickson, Jocelyn Compton, Behnoush Khorsand, Angie S Morris, Aliasger K Salem, Douglas C Fredericks, Todd O McKinley, James A Martin
We tested whether inhibiting mechanically responsive articular chondrocyte mitochondria after severe traumatic injury and preventing oxidative damage represent a viable paradigm for posttraumatic osteoarthritis (PTOA) prevention. We used a porcine hock intra-articular fracture (IAF) model well suited to human-like surgical techniques and with excellent anatomic similarities to human ankles. After IAF, amobarbital or N -acetylcysteine (NAC) was injected to inhibit chondrocyte electron transport or downstream oxidative stress, respectively...
February 7, 2018: Science Translational Medicine
https://www.readbyqxmd.com/read/29412694/lateral-ankle-sprain-in-a-mouse-model-lifelong-sensorimotor-dysfunction
#20
Erik A Wikstrom, Tricia Hubbard-Turner, Sophie Guderian, Michael J Turner
CONTEXT:   Ankle sprains are the most common orthopaedic injury that occurs during sport and physical activity. Many individuals who sprain their ankles develop chronic ankle instability (CAI), a condition characterized by recurrent injury, decreased physical activity, and decreased quality of life. These residual impairments are believed to persist for the remainder of the patient's life, in part due to the link between CAI and posttraumatic ankle osteoarthritis. However, this belief remains speculative due to the lack of long-term prospective investigations...
March 2018: Journal of Athletic Training
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