Michelle M Dunk, Jie Li, Simin Liu, Ramon Casanova, Jiu-Chiuan Chen, Mark A Espeland, Kathleen M Hayden, JoAnn E Manson, Stephen R Rapp, Aladdin H Shadyab, Linda G Snetselaar, Linda Van Horn, Robert Wild, Ira Driscoll
INTRODUCTION: Whether apolipoprotein E's (APOE's) involvement in lipid metabolism contributes to Alzheimer's disease (AD) risk remains unknown. METHODS: Incident probable dementia and cognitive impairment (probable dementia+mild cognitive impairment) were analyzed in relation to baseline serum lipids (total, low-density lipoprotein [LDL], high-density lipoprotein [HDL], non-HDL cholesterol, total-to-HDL, LDL-to-HDL, remnant cholesterol, and triglycerides) using Mendelian randomization in 5358 postmenopausal women from the Women's Health Initiative Memory Study...
July 12, 2023: Alzheimer's & Dementia: the Journal of the Alzheimer's Association