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HDL Dementia

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https://www.readbyqxmd.com/read/29777621/serum-high-density-lipoprotein-cholesterol-is-a-protective-predictor-of-executive-function-in-older-patients-with-diabetes-mellitus
#1
Yue Sun, Jenny Lee, Ronald C Ma, Timothy Kwok
INTRODUCTION: Older people with diabetes mellitus (DM) are at high risk for cognitive impairment or dementia. The clinical predictors for cognitive decline in older people with DM were elucidated. METHODS: This was a secondary analysis of a vitamin B12 intervention trial in older people with DM. 271 non-demented subjects were followed up at nine months interval for 27 months. We explored the association between baseline clinical features with changes in cognitive measures (clinical dementia rating scale, neuropsychological test battery including executive function z scores, psychomotor speed z scores and memory z scores)...
May 19, 2018: Journal of Diabetes Investigation
https://www.readbyqxmd.com/read/29742249/oxldl-plasma-levels-in-patients-with-alzheimer-s-disease
#2
Marina Felipe Grossi, Maria das Graças Carvalho, Josianne Nicácio Silveira, Gisele Santos Gonçalves, Karina Braga Gomes, Maria Aparecida Bicalho, Ieda de Fátima Oliveira Silva
OBJECTIVE: The objective of this study was to characterize the conventional lipid profile, oxLDL levels and ApoE polymorphism in patients with Alzheimer's disease (AD) and in elderly individuals without cognitive impairment. METHODS: Eighty elderly individuals were selected and the levels of oxLDL were determined using the ELISA kit, and ApoE gene polymorphism was investigated using polymerase chain reaction-restriction fragment length polymorphism. RESULTS: Significantly reduced levels of oxLDL were observed in patients with AD compared to the control group...
April 2018: Arquivos de Neuro-psiquiatria
https://www.readbyqxmd.com/read/29740562/effects-of-exercise-training-on-stroke-risk-factors-homocysteine-concentration-and-cognitive-function-according-the-apoe-genotype-in-stroke-patients
#3
Jun-Hee Lee, Sang-Min Hong, Yun-A Shin
The apolipoprotein E ( APOE ) gene has been suggested to be associated with stroke and dementia. However, the effects of exercise training on dementia according to the APOE genotype are not consistent to those reported by previous studies. Therefore, we examined the effects of exercise training on stroke risk factors including blood pressure, lipid profiles, homocysteine (Hcy) concentrations, and cognitive function according to the APOE genotype in stroke patients. We examined the stroke risk factors, Hcy, and cognitive function in 28 ischemic stroke patients before and after 6 months of exercise training...
April 2018: Journal of Exercise Rehabilitation
https://www.readbyqxmd.com/read/29519576/association-of-branched-chain-amino-acids-and-other-circulating-metabolites-with-risk-of-incident-dementia-and-alzheimer-s-disease-a-prospective-study-in-eight-cohorts
#4
Juho Tynkkynen, Vincent Chouraki, Sven J van der Lee, Jussi Hernesniemi, Qiong Yang, Shuo Li, Alexa Beiser, Martin G Larson, Katri Sääksjärvi, Martin J Shipley, Archana Singh-Manoux, Robert E Gerszten, Thomas J Wang, Aki S Havulinna, Peter Würtz, Krista Fischer, Ayse Demirkan, M Arfan Ikram, Najaf Amin, Terho Lehtimäki, Mika Kähönen, Markus Perola, Andres Metspalu, Antti J Kangas, Pasi Soininen, Mika Ala-Korpela, Ramachandran S Vasan, Mika Kivimäki, Cornelia M van Duijn, Sudha Seshadri, Veikko Salomaa
INTRODUCTION: Metabolite, lipid, and lipoprotein lipid profiling can provide novel insights into mechanisms underlying incident dementia and Alzheimer's disease. METHODS: We studied eight prospective cohorts with 22,623 participants profiled by nuclear magnetic resonance or mass spectrometry metabolomics. Four cohorts were used for discovery with replication undertaken in the other four to avoid false positives. For metabolites that survived replication, combined association results are presented...
February 28, 2018: Alzheimer's & Dementia: the Journal of the Alzheimer's Association
https://www.readbyqxmd.com/read/29173807/association-between-hemostatic-markers-serum-lipid-fractions-and-progression-of-cerebral-small-vessel-disease-a-2-year-follow-up-study
#5
Jacek Staszewski, Renata Piusińska-Macoch, Bogdan Brodacki, Ewa Skrobowska, Adam Stępień
INTRODUCTION: Little is known if hemostatic markers and serum lipid fractions can predict further radiological progression beyond vascular risk factors in cerebral small vessel disease (SVD). We investigated whether they are associated with SVD radiological progression and if they are related to different SVD clinical manifestations. METHODS: A single-center, prospective, cohort study with 2 years of radiological follow-up was performed in consecutive patients with different SVD manifestations...
January 2018: Neurologia i Neurochirurgia Polska
https://www.readbyqxmd.com/read/28994390/clearance-of-beta-amyloid-is-facilitated-by-apolipoprotein-e-and-circulating-high-density-lipoproteins-in-bioengineered-human-vessels
#6
Jerome Robert, Emily B Button, Brian Yuen, Megan Gilmour, Kevin Kang, Arvin Bahrabadi, Sophie Stukas, Wenchen Zhao, Iva Kulic, Cheryl L Wellington
Amyloid plaques, consisting of deposited beta-amyloid (Aβ), are a neuropathological hallmark of Alzheimer's Disease (AD). Cerebral vessels play a major role in AD, as Aβ is cleared from the brain by pathways involving the cerebrovasculature, most AD patients have cerebrovascular amyloid (cerebral amyloid angiopathy (CAA), and cardiovascular risk factors increase dementia risk. Here we present a notable advance in vascular tissue engineering by generating the first functional 3-dimensioinal model of CAA in bioengineered human vessels...
October 10, 2017: ELife
https://www.readbyqxmd.com/read/28709820/sex-dependent-difference-in-the-relationship-between-adipose-tissue-cholesterol-efflux-and-estradiol-concentrations-in-young-healthy-humans
#7
Fatima Iqbal, William J Durham, Ayyash Melhem, Saleem Raslan, Tony T Tran, Traver J Wright, Rabia Asghar, Ken Fujise, Elena Volpi, Labros Sidossis, Nicola Abate, Melinda Sheffield-Moore, Demidmaa Tuvdendorj
BACKGROUND: Impaired adipose tissue function and lower levels of high density lipoprotein cholesterol (HDL-C) have been implicated in the development of vascular dementia, and metabolic diseases such as hypertension, atherosclerosis, type 2 diabetes (T2D) and metabolic syndrome. Interestingly, both the substrate fluxes in adipose tissue and HDL-C concentration differ between men and women. Moreover, adipose tissue cholesterol efflux has been implicated in modulation of HDL-C levels. Thus, we aimed to determine if the association between serum estradiol levels and adipose tissue cholesterol efflux is sex-dependent...
February 2018: International Journal of Developmental Neuroscience
https://www.readbyqxmd.com/read/28551695/down-syndrome-increased-risk-of-dementia-and-lipid-disturbances
#8
REVIEW
Anna Kłosowska, Agnieszka Ćwiklińska, Agnieszka Kuchta, Agata Berlińska, Maciej Jankowski, Jolanta Wierzba
Down syndrome (DS) is the most common chromosomal aberration and genetically determined cause of intellectual disability. DS patients often present with some congenital defects and chronic diseases, including early onset dementia, which affects 70% of DS patients over 55 years of age and has a clinical presentation similar to Alzheimer disease (AD). The symptoms of DS originate from excessive genetic material within the "critical region" of the 21st chromosome. The "critical region" encompasses genes potentially associated with increase risk of dementia, e...
2017: Developmental Period Medicine
https://www.readbyqxmd.com/read/28550271/the-pleiotropic-vasoprotective-functions-of-high-density-lipoproteins-hdl
#9
Guilaine Boyce, Emily Button, Sonja Soo, Cheryl Wellington
The pleiotropic functions of circulating high density lipoprotein (HDL) on peripheral vascular health are well established. HDL plays a pivotal role in reverse cholesterol transport and is also known to suppress inflammation, endothelial activation and apoptosis in peripheral vessels. Although not expressed in the central nervous system, HDL has nevertheless emerged as a potential resilience factor for dementia in multiple epidemiological studies. Animal model data specifically support a role for HDL in attenuating the accumulation of β-amyloid within cerebral vessels concomitant with reduced neuroinflammation and improved cognitive performance...
May 26, 2017: Journal of Biomedical Research
https://www.readbyqxmd.com/read/28498386/atorvastatin-inhibits-cholesterol-induced-caspase-3-cleavage-through-down-regulation-of-p38-and-up-regulation-of-bcl-2-in-the-rat-carotid-artery
#10
Roshanak Bayatmakoo, Nadereh Rashtchizadeh, Parichehreh Yaghmaei, Mehdi Farhoudi, Pouran Karimi
AIM: Atherosclerotic lesions in the carotid arteries lead to a broad range of cerebrovascular disorders such as vascular dementia and ischaemic stroke. Recent studies have verified the beneficial role of atorvastatin (AV) in atherosclerosis. Despite a large body of studies, the mechanisms underlying this effect have not been completely explained. In this study, several experiments were performed on atherosclerotic rat models to investigate the anti-inflammatory and anti-apoptotic effect of AV in the carotid artery...
September 2017: Cardiovascular Journal of Africa
https://www.readbyqxmd.com/read/28421328/association-of-adiponectin-leptin-and-resistin-with-inflammatory-markers-and-obesity-in-dementia
#11
Małgorzata Bednarska-Makaruk, Ałła Graban, Anna Wiśniewska, Wanda Łojkowska, Anna Bochyńska, Magdalena Gugała-Iwaniuk, Ksenia Sławińska, Agnieszka Ługowska, Danuta Ryglewicz, Hanna Wehr
The aim of the study was to determine the role of adiponectin, leptin and resistin in various types of dementia and to investigate their association with inflammatory markers, insulin resistance and abdominal obesity. In 205 patients with dementia [89 with Alzheimer's disease (AD), 47 with vascular dementia (VaD), 69 with mixed dementia (MD)], 113 persons with mild cognitive impairment and in 107 controls serum adiponectin, leptin and resistin levels, pro-inflammatory [interleukin-6 (IL-6), C-reactive protein (hsCRP) and chitotriosidase] and anti-inflammatory (25-OH vitamin D, HDL-cholesterol and paraoxonase 1) markers, as well as glucose metabolism parameters (glucose, insulin and HOMA-IR) were determined...
August 2017: Biogerontology
https://www.readbyqxmd.com/read/28390146/abdominal-obesity-and-white-matter-microstructure-in-midlife
#12
Alex Cole Birdsill, Stephanie Oleson, Sonya Kaur, Evan Pasha, Adele Ireton, Hirofumi Tanaka, Andreana Haley
The aging U.S. population and the recent rise in the prevalence of obesity are two phenomena of great importance to public health. In addition, research suggests that midlife body mass index (BMI) is a risk factor for dementia, a particularly costly disease, in later life. BMI could influence brain health by adversely impacting cerebral white matter. Recently, greater BMI has been associated with lower white matter fractional anisotropy (FA), an index of tissue microstructure, as measured by diffusion-tensor imaging in midlife...
April 8, 2017: Human Brain Mapping
https://www.readbyqxmd.com/read/28350817/differential-associations-of-plasma-lipids-with-incident-dementia-and-dementia-subtypes-in-the-3c-study-a-longitudinal-population-based-prospective-cohort-study
#13
Sabrina Schilling, Christophe Tzourio, Aïcha Soumaré, Sara Kaffashian, Jean-François Dartigues, Marie-Laure Ancelin, Cécilia Samieri, Carole Dufouil, Stéphanie Debette
BACKGROUND: Vascular risk factors have been proposed as important targets for the prevention of dementia. As lipid fractions represent easily modifiable targets, we examined the longitudinal relationship of baseline lipid fractions with 13-y incident dementia and its subtypes (Alzheimer disease [AD] and mixed or vascular dementia) in older community-dwelling persons. METHODS AND FINDINGS: Non-institutionalized persons aged 65+ y (n = 9,294) were recruited for the Three-City Study (3C Study), a population-based cohort study from the electoral rolls of the cities of Dijon, Bordeaux, and Montpellier, France, between March 1999 and March 2001...
March 2017: PLoS Medicine
https://www.readbyqxmd.com/read/28324763/interaction-of-apoe-e4-and-poor-glycemic-control-predicts-white-matter-hyperintensity-growth-from-73-to-76
#14
Simon R Cox, Stuart J Ritchie, David Alexander Dickie, Alison Pattie, Natalie A Royle, Janie Corley, Benjamin S Aribisala, Sarah E Harris, Maria Valdés Hernández, Alan J Gow, Susana Muñoz Maniega, John M Starr, Mark E Bastin, Joanna M Wardlaw, Ian J Deary
We examined whether apolipoprotein E (APOE) status interacts with vascular risk factors (VRFs) to predict the progression of white matter hyperintensities (WMHs) on brain MRI scans over a specific period of life in older age when the risk of dementia increases. At age 73 years, baseline VRFs were assessed via self-reported history of diabetes, hypertension, smoking, and hypercholesterolemia, and via objective measures of blood HbA1c, body mass index, diastolic and systolic blood pressure, and blood high-density lipoprotein to total cholesterol (HDL) ratio...
June 2017: Neurobiology of Aging
https://www.readbyqxmd.com/read/28274859/longitudinal-lipid-profile-variations-and-clinical-change-in-alzheimer-s-disease-dementia
#15
Fabricio Ferreira de Oliveira, Elizabeth Suchi Chen, Marilia Cardoso Smith, Paulo Henrique Ferreira Bertolucci
Hypercholesterolemia and statin use have been unevenly associated with clinical change in Alzheimer's disease dementia. In this longitudinal study, 192 consecutive outpatients with late-onset Alzheimer's disease dementia were stratified according to APOE haplotypes, and followed for one year to investigate associations of lipid profile variations and lipophilic statin therapy with changes in cognition, caregiver burden, basic and instrumental functionality. Overall, 102 patients (53.1%) carried APOE4+ haplotypes and 90 (46...
April 12, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/28270179/blood-cholesterol-in-late-life-and-cognitive-decline-a-longitudinal-study-of-the-chinese-elderly
#16
Chaoran Ma, Zhaoxue Yin, Pengfei Zhu, Jiesi Luo, Xiaoming Shi, Xiang Gao
BACKGROUND: Previous studies regarding the lipid-cognition relation in older adults are limited and have generated mixed results. We thus examined whether higher blood cholesterol concentrations were associated with faster cognitive decline in a community-based longitudinal study of Chinese elderly. METHODS: The study included 1,159 Chinese adults aged over 60 years (women: 48.7%, mean age: 79.4 years), who were free of dementia, Parkinson disease and stroke at the baseline...
March 7, 2017: Molecular Neurodegeneration
https://www.readbyqxmd.com/read/28239527/uric-acid-is-associated-with-vascular-dementia-in-chinese-population
#17
Yuzhen Xu, Qian Wang, Ruiting Cui, Kaili Lu, Yunlin Liu, Yuwu Zhao
OBJECTIVE: Mounting evidence suggests that oxidative stress is involved in the pathogenesis of vascular dementia (VD). Uric acid (UA) has long been implicated as a critical cause of cardiovascular disease. Nevertheless, UA was also expected to play an important role in antioxidant and neuroprotection recently. We hypothesized that UA may have a protective role against VD. The aim of this study was to investigate the link between serum UA and cognitive dysfunction in VD. MATERIALS AND METHODS: There were altogether 127 VD subjects and 81 nondemented controls enrolled in our study...
February 2017: Brain and Behavior
https://www.readbyqxmd.com/read/28223934/plasma-cystatin-c-and-high-density-lipoprotein-are-important-biomarkers-of-alzheimer-s-disease-and-vascular-dementia-a-cross-sectional-study
#18
Rui Wang, Zhaoyu Chen, Yongmei Fu, Xiaobo Wei, Jinchi Liao, Xu Liu, Bingjun He, Yunqi Xu, Jing Zou, Xiaoyan Yang, Ruihui Weng, Sheng Tan, Christopher McElroy, Kunlin Jin, Qing Wang
Objectives: Cystatin C (Cys C) and high-density lipoprotein (HDL) play critical roles in neurodegenerative diseases, such as dementia, Alzheimer's disease (AD) and vascular dementia (VaD). However, whether they can be used as reliable biomarkers to distinguish patients with dementia from healthy subjects and to determine disease severity remain largely unknown. Methods: We conducted a cross-sectional study to determine plasma Cys C and HDL levels of 88 patients with dementia (43 AD patients, 45 VaD patients) and 45 healthy age-matched controls...
2017: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/28035918/apolipoprotein-a1-in-cerebrospinal-fluid-and-plasma-and-progression-to-alzheimer-s-disease-in-non-demented-elderly
#19
Rosalinde E R Slot, Argonde C Van Harten, Maartje I Kester, Wesley Jongbloed, Femke H Bouwman, Charlotte E Teunissen, Philip Scheltens, Robert Veerhuis, Wiesje M van der Flier
BACKGROUND: HDL-cholesterol transporter Apolipoprotein A1 (ApoA1) holds neuroprotective properties, such as inhibition of amyloid-β aggregation. Low plasma ApoA1 concentrations are associated with Alzheimer's disease (AD). Little is known about ApoA1 levels in the pre-dementia stages of AD. OBJECTIVE: To investigate associations between cerebrospinal fluid (CSF) and plasma ApoA1 levels and clinical progression toward AD in non-demented elderly. METHODS: From the Amsterdam Dementia Cohort, we included 429 non-demented elderly with subjective cognitive decline (SCD; n = 206, 61±9 years, Mini-Mental State Exam (MMSE) 28±2) and mild cognitive impairment (MCI; n = 223, 67±8 years, MMSE 27±2), with a mean follow-up of 2...
2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/27911314/updating-the-evidence-on-the-association-between-serum-cholesterol-and-risk-of-late-life-dementia-review-and-meta-analysis
#20
REVIEW
Kaarin J Anstey, Kimberly Ashby-Mitchell, Ruth Peters
BACKGROUND: Cohort studies have reported that midlife high total serum cholesterol (TC) is associated with increased risk of Alzheimer's disease (AD) in late-life but findings have been based on few studies and previous reviews have been limited by a lack of compatible data. OBJECTIVE: We synthesized all high quality data from cohort studies reporting on the association between total serum cholesterol measured and late-life cognitive outcomes including Alzheimer's disease (AD), vascular dementia (VaD), any dementia, mild cognitive impairment (MCI), and cognitive decline...
2017: Journal of Alzheimer's Disease: JAD
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