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Anne Blanchard, Emmanuel Curis, Tiphaine Guyon-Roger, Diana Kahila, Cyrielle Treard, Véronique Baudouin, Etienne Bérard, Gérard Champion, Pierre Cochat, Julie Dubourg, Renaud de la Faille, Olivier Devuyst, Georges Deschenes, Michel Fischbach, Jérôme Harambat, Pascal Houillier, Alexandre Karras, Bertrand Knebelmann, Marie-Pierre Lavocat, Chantal Loirat, Elodie Merieau, Patrick Niaudet, François Nobili, Robert Novo, Rémi Salomon, Tim Ulinski, Xavier Jeunemaître, Rosa Vargas-Poussou
Dent disease classically combines low-molecular-weight proteinuria, hypercalciuria with nephrocalcinosis, and renal failure. Nephrotic range proteinuria, normal calciuria, and hypokalemia have been rarely reported. It is unknown whether the changes in phenotype observed over time are explained by a decrease in glomerular filtration rate (GFR) or whether there is any phenotype-genotype relationship. To answer this we retrospectively analyzed data from 109 male patients with CLCN5 mutations (Dent-1) and 9 patients with mutation of the OCRL gene (Dent-2)...
August 2016: Kidney International
C Noilhan, M Barigou, L Bieler, J Amar, B Chamontin, B Bouhanick
OBJECTIVE: To study the prevalence of different causes of hypertension in young adults referred to a hypertension center in the south west of France. METHODS: We conducted a retrospective overview of patients younger than 40years old hospitalized consecutively in the Hypertension department of Toulouse University Hospital between 2012 and 2014. Clinical data about gender, age, anthropomorphic parameters and blood pressure measurement by 24h Ambulatory Blood Pressure Monitoring (ABPM) were recorded...
June 2016: Annales de Cardiologie et D'angéiologie
Jean-Philippe Bertocchio, Coralie Barbe, Sylvie Lavaud, Olivier Toupance, Pierre Nazeyrollas, Frederic Jaisser, Philippe Rieu
BACKGROUND: Animal studies have highlighted the role of vascular mineralocorticoid receptor during Cyclosporine A-induced nephrotoxicity. Mineralocorticoid receptor antagonists could improve kidney survival but are not commonly used during renal impairment and in association with several immunosuppressive drugs due to a supposed higher risk of adverse events. We tested the tolerance of eplerenone according to its expected adverse events: hyperkalemia, metabolic acidosis, hypotension, acute kidney failure, or any other adverse event...
2016: PloS One
W Grira, F Chaker, M Yazidi, C Denguir, M Tebib, M Chihaoui, H Slimane
OBJECTIFS: L'hyperaldostéronisme primaire est la première cause d'HTA endocrinienne. La morbidité et la mortalité de la maladie sont liées à l'hypertension artérielle et à l'hypokaliémie. Les objectifs de ce travail étaient de comparer l'évolution de l'HTA et de la kaliémie des patients ayant un hyperaldostéronisme primaire selon le type de traitement choisi. MéTHODES: Étude rétrospective portant sur 50 patients ayant un hyperaldostéronisme primaire avec un suivi minimum de 6 mois après traitement...
December 2015: Annales de Cardiologie et D'angéiologie
M Vallet, A Martin, E Huyghe, J Kantambadouno, J Amar, B Chamontin, I Tack, B Bouhanick
BACKGROUND: Aldosterone-producing adenoma is classically treated by unilateral adrenalectomy. Severe hyperkalemia, related to adrenal insufficiency, have been already reported after surgery. We describe here 4 male patients who, despite subnormal kalemia, developed a failure of the renin-aldosterone (RA) axis, resulting in a decrease in extracellular fluid volume (ECFV) following surgery METHODS: PA diagnosis was established according to French recommendations. Unilateral adrenalectomy was performed in all...
December 2015: Annales de Cardiologie et D'angéiologie
Maria-Christina Zennaro, Sheerazed Boulkroun, Fabio Fernandes-Rosa
Aldosterone plays an essential role in the maintenance of fluid and electrolyte homeostasis in the distal nephron. Monogenic forms of mineralocorticoid hypertension result from genetic defects leading to excessive production of aldosterone (or other mineralocorticoids) from the adrenal cortex or to illegitimate mineralocorticoid effects in the kidney. They are characterized in the majority of cases by early onset, severe or resistant hypertension and associated with suppressed renin levels. Depending on their causes, these diseases are distinguished at the clinical and biochemical level and differently affect aldosterone levels and kalemia...
August 2015: Best Practice & Research. Clinical Endocrinology & Metabolism
Luis Nogueira-Silva, Anne Blanchard, Emmanuel Curis, Aurélien Lorthioir, Valentina Zhygalina, Damien Bergerot, Stéphanie Baron, Laurence Amar, Guillaume Bobrie, Pierre-François Plouin, Joël Ménard, Michel Azizi
CONTEXT: The role of vasopressin (AVP) in the pathophysiology of primary aldosteronism (PA) remains unclear. OBJECTIVES: The primary aim of this study was to investigate AVP secretion in PA by measuring the plasma concentration of copeptin (PCop), the C-terminal portion of provasopressin. The secondary aim was to assess renal sensitivity to AVP. DESIGN AND SETTING: This was a cross-sectional study in a tertiary-care hospital. PROTOCOL: We recruited 115 patients with PA, 48 patients with essential hypertension (EH), and 108 normotensive healthy subjects (HS)...
September 2015: Journal of Clinical Endocrinology and Metabolism
Nieves Martell-Claros, María Abad-Cardiel, Beatriz Alvarez-Alvarez, José A García-Donaire, Cristina Fernández Pérez
BACKGROUND: Primary aldosteronism is the most frequent endocrine cause of secondary hypertension. Aldosterone excess damages the cardiovascular system. OBJECTIVES: We compared biochemical; morphological, and cardiovascular risk differences among hypokalemic and normokalemic primary aldosteronism. We evaluated either both presentations correspond to two different entities or a unique disease in different evolutive stage. MATERIAL AND METHODS: This is a retrospective study including 157 patients with primary aldosteronism divided into two groups: typical presentation (serum potassium < 3...
June 2015: Journal of Hypertension
Olivier Hanon, Clemence Boully, Laure Caillard, Florian Labourée, Sophie Cochiello, Edouard Chaussade
BACKGROUND: Combination treatments for hypertension most often include a renin-angiotensin-aldosterone system (RAAS) inhibitor. However, systolic blood pressure (SBP) remains difficult to control. Non-RAAS-inhibiting strategies such as calcium channel blocker/thiazide-like diuretic combinations may offer effective alternatives. METHODS: Hypertensive diabetic patients with microalbuminuria were included in this retrospective, post-hoc analysis of the Natrilix SR Versus Enalapril Study in Hypertensive Type 2 Diabetics With MicrOalbuminuRia (NESTOR) trial if they were uncontrolled on monotherapy (indapamide slow release (SR) 1...
August 2015: American Journal of Hypertension
Marilisa Citton, Giovanni Viel, Gian Paolo Rossi, Franco Mantero, Donato Nitti, Maurizio Iacobone
PURPOSE: The aim of this retrospective study was to analyze the early and long-term outcomes of the surgical treatment of primary aldosteronism (PA), the most common surgically correctable cause of endocrine hypertension. METHODS: Serum Potassium levels, blood pressure values, and aldosterone/renin ratio (ARR) were assessed in 128 patients undergoing unilateral adrenalectomy for PA, before and after surgery. The role of lateralizing techniques and the relationship between outcome and histopathology findings were also evaluated...
April 2015: Langenbeck's Archives of Surgery
Mirza Faisal Ahmed Rafiq, Noor Ahmed, Adil Aziz Khan
BACKGROUND: Electrolyte derangements are common sequel of traumatic brain injury. Use of intravenous fluids, diuretics, syndrome of inappropriate ADH secretion and cerebral salt washing are some of the factors responsible for this. Proper in time detection followed by appropriate treatment not only improves neurological status but also decrease morbidity and mortality. This study was conducted to know serum derangements of different electrolytes in patients with traumatic brain injury...
January 2013: Journal of Ayub Medical College, Abbottabad: JAMC
Catherine L Stables, Hassan Musa, Aditi Mitra, Sandesh Bhushal, Makarand Deo, Guadalupe Guerrero-Serna, Sergey Mironov, Manuel Zarzoso, Karen L Vikstrom, William Cawthorn, Sandeep V Pandit
Diabetes is associated with an increased risk of sudden cardiac death, but the underlying mechanisms remain unclear. Our goal was to investigate changes occurring in the action potential duration (APD) and conduction velocity (CV) in the diabetic rabbit ventricle, and delineate the principal ionic determinants. A rabbit model of alloxan-induced diabetes was utilized. Optical imaging was used to record electrical activity in isolated Langendorff-perfused hearts in normo-, hypo- and hyper-kalemia ([K(+)]o=4, 2, 12 mM respectively)...
April 2014: Journal of Molecular and Cellular Cardiology
S Feloni, L Radermacher, C Remy, J Jousten, V Corman
Mrs. A, a 62 year old patient with a history of hypertension, polyuria and polydipsia is hospitalized after a malaise. A severe hypokalemia, which is the cause of the polyuria and polydipsia, is discovered. The presence of hypertension and hypokalemia arises suspicion of a primary hyperaldosteronism and the plasma levels of renin and aldosterone are measured. Elevated aldosterone levels are combined with high plasma renin concentrations which permits to rule out primary hyperaldosteronism. Further explorations reveal a subocclusive ostial stenosis of the right renal artery...
July 2013: Revue Médicale de Liège
Grégoire Ficheur, Emmanuel Chazard, Béatrice Merlin, Laurie Ferret, Michel Luyckx, Régis Beuscart
Hospitals have at their disposal large databases that may be considered for reuse. The objective of this work is to evaluate the impact of a drug on a specific laboratory result by analyzing these data. This analysis first involves building a record of temporal patterns, including medical context, of drug prescriptions. Changes in outcome due to these patterns of drug prescription are assessed using short phases of the inpatient stay compared to monotonous changes in the laboratory result. To illustrate this technique, we investigated potassium chloride supplementation and its impact on kalemia...
2013: Studies in Health Technology and Informatics
Ewa Wunsch, Grzegorz Naprawa, Dorota Koziarska, Malgorzata Milkiewicz, Przemyslaw Nowacki, Piotr Milkiewicz
INTRODUCTION: Hyponatremia is associated with high mortality and predicts hepatic encephalopathy but its effect on health-related quality of life remains to be established. MATERIAL AND METHODS: In this study we prospectively analyzed the relationship between hyponatremia, clinical features and quality of life in a cohort of 116 patients with cirrhosis. Chronic Liver Disease Questionnaire and Medical Outcomes Study 36- Item Short Form Health Survey were performed to assess quality of life...
May 2013: Annals of Hepatology
R A Trifanescu, R Danciulescu Miulescu, M Carsote, C Poiana
BACKGROUND: periodic paralysis related to hypokalemia is seldom reported in thyrotoxicosis, and it usually occurs in Asian males. PATIENTS AND METHODS: Two Romanian (Caucasian) young patients presented with hypokalemic paralysis. TSH, FT4, TT3 was measured by immunochemiluminescence. Case report 1. Patient O.R, aged 19, presented marked asthenia and lower limbs paralysis, following high carbohydrate meal. He declared 10 kg weight loss on hypocaloric diet and mild sweating...
March 15, 2013: Journal of Medicine and Life
Milan R Radovanović, Dragan R Milovanović, Dragana Ignjatović-Ristić, Mirjana S Radovanović
INTRODUCTION: Long-time consumption of narcotics leads to altered mental status of the addict. It is also connected to damages of different organic systems and it often leads to appearance of multiple organ failure. Excessive narcotics consumption or abuse in a long time period can lead to various consequences, such as atraumatic rhabdomyolysis, acute renal failure and electrolytic disorders. Rhabdomyolysis is characterized by injury of skeletal muscle with subsequent release of intracellular contents, such as myoglobin, potassium and creatine phosphokinase...
October 2012: Vojnosanitetski Pregled. Military-medical and Pharmaceutical Review
Shereen Abdelghaffar, Yasmeen Mansi, Reem Ibrahim, Dina Mohamed
BACKGROUND: Preterm neonates comprise the most heavily transfused group of patients, and about 85% of extremely low birth weight newborns receive a transfusion by the end of their hospital stay. The aim of this study was to assess the possible metabolic effects of RBC transfusion on preterm infants, especially during the first 2 weeks of life, and its relation to blood volume. MATERIALS AND METHODS: This study was conducted on 40 preterm neonates with gestational age of less than or equal to 34 weeks...
January 2012: Asian Journal of Transfusion Science
Francesco Meriggi, Paolo Gramigna, Paola Tramelli
Background. The aim of this study is to investigate the evidence of hypokalemia as a suitable parameter for therapeutic decision making after severe blunt liver trauma. Methods. We reviewed the medical records of 11 patients (9 M, 2 F, mean age 32 years) admitted to San Matteo Hospital of Pavia between 2007-2009. All of them were victims of road accidents hospitalized for blunt liver injury and submitted to surgery. Results. Hypokalemia was observed in 7/11 (63.6%) patients during the preoperative period (mean value 2...
2012: HPB Surgery: a World Journal of Hepatic, Pancreatic and Biliary Surgery
François Simon, Quentin Bertrand, Yves Pirson, Bruno Flamion, Guy Loute
We report on two patients on chronic hemodialysis, who presented with typical symptoms of hyperkalemia (lower limb paresia and characteristic electrocardiogram [ECG]) for an only mildly increased kalemia (6.1 and 6.2 mEq/L), values that are frequently seen in asymptomatic patients on chronic hemodialysis. Their common denominator was a concomitant hypocalcemia (7.5 et 6.4mg/dL) induced by cinacalcet treatment. Hypocalcemia has very likely precipitated the occurrence of clinical and electrocardiological manifestations of hyperkalemia...
November 2012: Néphrologie & Thérapeutique
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