keyword
MENU ▼
Read by QxMD icon Read
search

SIOP

keyword
https://www.readbyqxmd.com/read/29755120/heterogeneous-mycn-amplification-in-neuroblastoma-a-siop-europe-neuroblastoma-study
#1
Ana P Berbegall, Dominik Bogen, Ulrike Pötschger, Klaus Beiske, Nick Bown, Valérie Combaret, Raffaella Defferrari, Marta Jeison, Katia Mazzocco, Luigi Varesio, Ales Vicha, Shifra Ash, Victoria Castel, Carole Coze, Ruth Ladenstein, Cormac Owens, Vassilios Papadakis, Ellen Ruud, Gabriele Amann, Angela R Sementa, Samuel Navarro, Peter F Ambros, Rosa Noguera, Inge M Ambros
BACKGROUND: In neuroblastoma (NB), the most powerful prognostic marker, the MYCN amplification (MNA), occasionally shows intratumoural heterogeneity (ITH), i.e. coexistence of MYCN-amplified and non-MYCN-amplified tumour cell clones, called heterogeneous MNA (hetMNA). Prognostication and therapy allocation are still unsolved issues. METHODS: The SIOPEN Biology group analysed 99 hetMNA NBs focussing on the prognostic significance of MYCN ITH. RESULTS: Patients <18 months (18 m) showed a better outcome in all stages as compared to older patients (5-year OS in localised stages: <18 m: 0...
May 14, 2018: British Journal of Cancer
https://www.readbyqxmd.com/read/29734694/hearing-loss-in-adult-survivors-of-childhood-cancer-treated-with-radiotherapy
#2
Amber Khan, Amy Budnick, Dana Barnea, Darren R Feldman, Kevin C Oeffinger, Emily S Tonorezos
The ototoxic effects of radiotherapy have been poorly characterized. We examined adult survivors of childhood cancer who were treated with radiotherapy, which included the head, before the age of 22 years and between 1952 and 2016. Those who received platinum chemotherapy were excluded. Demographic, diagnosis, and treatment outcomes were captured. Audiograms were graded using the Chang and International Society of Paediatric Oncology ototoxicity (SIOP) scales. Among 276 patients with a history of radiation to sites that included the brain, orbit, nasopharynx, and total body irradiation, the median age at treatment was 10...
May 4, 2018: Children
https://www.readbyqxmd.com/read/29729847/siope-brain-tumor-group-consensus-guideline-on-craniospinal-target-volume-delineation-for-high-precision-radiotherapy
#3
Thankamma Ajithkumar, Gail Horan, Laetitia Padovani, Nicky Thorp, Beate Timmermann, Claire Alapetite, Lorenza Gandola, Monica Ramos, Karen Van Beek, Melissa Christiaens, Yasmin Lassen-Ramshad, Henriette Magelssen, Kristina Nilsson, Frank Saran, Barbara Rombi, Rolf Kortmann, Geert O Janssens
OBJECTIVE: To develop a consensus guideline for craniospinal target volume (TV) delineation in children and young adults participating in SIOPE studies in the era of high-precision radiotherapy. METHODS AND MATERIALS: During four consensus meetings (Cambridge, Essen, Liverpool, and Marseille), conventional field-based TV has been translated into image-guided high-precision craniospinal TV by a group of expert paediatric radiation oncologists and enhanced by MRI images of liquor distribution...
May 2, 2018: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/29698060/dosimetric-comparison-of-five-different-techniques-for-craniospinal-irradiation-across-15-european-centers-analysis-on-behalf-of-the-siop-e-btg-radiotherapy-working-group
#4
Enrica Seravalli, Mirjam Bosman, Yasmin Lassen-Ramshad, Anne Vestergaard, Foppe Oldenburger, Jorrit Visser, Efi Koutsouveli, Chryssa Paraskevopoulou, Gail Horan, Thankamma Ajithkumar, Beate Timmermann, Carolina-Sofia Fuentes, Gillian Whitfield, Thomas Marchant, Laetitia Padovani, Eloise Garnier, Lorenza Gandola, Silvia Meroni, Bianca A W Hoeben, Martijn Kusters, Claire Alapetite, Sandra Losa, Farid Goudjil, Henriette Magelssen, Morten Egeberg Evensen, Frank Saran, Gregory Smyth, Barbara Rombi, Roberto Righetto, Rolf-Dieter Kortmann, Geert O Janssens
PURPOSE: Conventional techniques (3D-CRT) for craniospinal irradiation (CSI) are still widely used. Modern techniques (IMRT, VMAT, TomoTherapy® , proton pencil beam scanning [PBS]) are applied in a limited number of centers. For a 14-year-old patient, we aimed to compare dose distributions of five CSI techniques applied across Europe and generated according to the participating institute protocols, therefore representing daily practice. MATERIAL AND METHODS: A multicenter (n = 15) dosimetric analysis of five different techniques for CSI (3D-CRT, IMRT, VMAT, TomoTherapy® , PBS; 3 centers per technique) was performed using the same patient data, set of delineations and dose prescription (36...
April 26, 2018: Acta Oncologica
https://www.readbyqxmd.com/read/29693799/evaluation-of-boost-irradiation-in-patients-with-intermediate-risk-stage-iii-wilms-tumour-with-positive-lymph-nodes-only-results-from-the-siop-wt-2001-registry
#5
Raquel Dávila Fajardo, Eva Oldenburger, Christian Rübe, Marta López-Yurda, Kathy Pritchard-Jones, Christophe Bergeron, Norbert Graf, Martine van Grotel, Harm van Tinteren, Daniel Saunders, Marry M van den Heuvel-Eibrink, Geert O Janssens, Foppe Oldenburger
OBJECTIVE: To evaluate the value of radiotherapy boost omission in patients with intermediate-risk, stage III Wilms tumours (WT) with positive lymph nodes (LN). METHODS AND MATERIALS: All patients with intermediate-risk, stage III (LN positive) WT consecutively registered in the SIOP-WT-2001 study were included in this analysis. Endpoints were 5-year event-free survival (EFS), loco-regional control (LRC) and overall survival (OS). RESULTS: Between June 2001 and May 2015, 2,569 patients with stage I to III WT after preoperative chemotherapy were registered in the SIOP-WT-2001 study...
April 25, 2018: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/29520437/central-nervous-system-cns-neuroblastoma-a-case-based-update
#6
Federico Bianchi, Gianpiero Tamburrini, Marco Gessi, Paolo Frassanito, Luca Massimi, Massimo Caldarelli
BACKGROUND: Primary central nervous system (CNS) neuroblastoma is a rare intracranial tumor affecting children mainly in the first years of life. It is usually a supratentorial tumor with a wide spectrum of clinical presentation, seizures, and focal neurological deficits being the most common presenting signs. CASE DESCRIPTION: A 2-year-old child was admitted to our ward after a generalized seizure. Neurological examination was normal. Radiological studies showed a small DWI hyperintense lesion of the right rectus gyrus...
May 2018: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://www.readbyqxmd.com/read/29501377/laparoscopic-nephrectomy-for-wilms-tumor-can-we-expand-on-the-current-siop-criteria
#7
Katherine Burnand, Annie Roberts, Aurore Bouty, Michael Nightingale, Martin Campbell, Yves Heloury
INTRODUCTION: Wilms' tumor now has a good overall prognosis with open radical nephrectomy having been the mainstay of surgical treatment. Recently laparoscopic nephrectomy (LN) has been growing in popularity. The aim of our study was to review our indications and outcomes for laparoscopic resections for Wilms' tumor and compare indications with International Society of Paediatric Oncology (SIOP) criteria for LN. MATERIAL AND METHODS: Patient demographics, preoperative management, surgical data, respect of SIOP criteria, complications, disease outcome, and follow-up were recorded on consecutive children who underwent nephrectomy for Wilms' tumor...
February 13, 2018: Journal of Pediatric Urology
https://www.readbyqxmd.com/read/29485128/position-paper-rationale-for-the-treatment-of-children-with-ccsk-in-the-umbrella-siop-rtsg-2016-protocol
#8
REVIEW
Saskia L Gooskens, Norbert Graf, Rhoikos Furtwängler, Filippo Spreafico, Christophe Bergeron, Gema L Ramírez-Villar, Jan Godzinski, Christian Rübe, Geert O Janssens, Gordan M Vujanic, Ivo Leuschner, Aurore Coulomb-L'Hermine, Anne M Smets, Beatriz de Camargo, Sara Stoneham, Harm van Tinteren, Kathy Pritchard-Jones, Marry M van den Heuvel-Eibrink
The International Society of Paediatric Oncology-Renal Tumour Study Group (SIOP-RTSG) has developed a new protocol for the diagnosis, treatment, and follow-up monitoring of childhood renal tumours - the UMBRELLA SIOP-RTSG 2016 protocol (the UMBRELLA protocol). This protocol has been designed to continue international collaboration in the treatment of childhood renal tumours and will be implemented in over 50 different countries. Clear cell sarcoma of the kidney, which is a rare paediatric renal tumour that most commonly occurs in children between 2 and 4 years of age, is specifically addressed in the UMBRELLA protocol...
May 2018: Nature Reviews. Urology
https://www.readbyqxmd.com/read/29419959/-nephroblastoma-long-term-experience-in-the-multidisciplinary-approach
#9
P Rodríguez Iglesias, A Serrano Durbá, L Rodríguez Caraballo, J Balaguer Guill, I Povo Martín, C Domínguez Hinarejos, F Boronat Tormo
OBJECTIVES: Main objective: to perform a descriptive study of patients with nephroblastoma, diagnostic tests, medical and surgical treatment. Secondary objective: to evaluate the rate of relapse and 5-year survival and risk factors for relapse and death. MATERIALS AND METHODS: Retrospective study of patients with nephroblastoma treated according to the protocol of the SIOP-2001. Demographic variables, comorbidities and associated syndromes were collected. Other data were tumor location, size, extent and stage...
February 1, 2018: Cirugía Pediátrica: Organo Oficial de la Sociedad Española de Cirugía Pediátrica
https://www.readbyqxmd.com/read/29383160/hmga2-overexpression-predicts-relapse-susceptibility-of-blastemal-wilms-tumor-patients
#10
Lourdes Hontecillas-Prieto, Daniel J García-Domínguez, Rosa García-Mejías, Gema L Ramírez-Villar, Carmen Sáez, Enrique de Álava
Wilms tumor (WT) is an embryonal malignant neoplasm of the kidney that accounts for 6-7% of all childhood cancers. WT seems to derive from multipotent embryonic renal stem cells that have failed to differentiate properly. Since mechanisms underlying WT tumorigenesis remain largely unknown, the aim of this study was to explore the expression of embryonic stem cell (ESC) markers in samples of WT patients after chemotherapy treatment SIOP protocol, as the gene expression patterns of ESC are like those of most cancer cells...
December 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/29373195/ototoxicity-and-cochlear-sparing-in-children-with-medulloblastoma-proton-vs-photon-radiotherapy
#11
Arnold C Paulino, Anita Mahajan, Rong Ye, David R Grosshans, M Fatih Okcu, Jack Su, Mary Frances McAleer, Susan McGovern, Victor A Mangona, Murali Chintagumpala
PURPOSE: To compare ototoxicity rates between medulloblastoma patients treated with protons vs. photons. MATERIALS AND METHODS: The study included 84 children diagnosed with medulloblastoma treated with either passively scattered protons (n = 38) or photons (n = 46). Patients underwent maximal safe resection followed by craniospinal irradiation, posterior fossa and/or tumor bed boost and chemotherapy according to one of 3 multi-institutional trials. Median audiogram follow-up was 56 months for protons and 66 months for photons...
January 17, 2018: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/29343527/visual-outcomes-after-chemotherapy-for-optic-pathway-glioma-in-children-with-and-without-neurofibromatosis-type-1-results-of-the-international-society-of-paediatric-oncology-siop-low-grade-glioma-2004-trial-uk-cohort
#12
Kevin Falzon, Evangelos Drimtzias, Susan Picton, Ian Simmons
AIMS: To report visual acuity (VA) outcomes following chemotherapy for optic pathway glioma (OPG) in children with or without neurofibromatosis type-1 (NF1) and to analyse associated risk factors. METHODS: A prospective, multicentre, cohort study involving 155 children treated between September 2004 and December 2012. Initial and final VA was used for per-eye and per-subject analysis. Correlation tests were performed to determine whether initial VA predicted final VA...
January 17, 2018: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/29318365/-innovations-in-surgical-treatment-of-pediatric-solid-tumors
#13
REVIEW
A Schmidt, S W Warmann, C Urla, J Fuchs
The overall survival of children with solid tumors has shown a substantial increase in the past decades due to progress in all of the disciplines involved in the treatment. The poor prognosis for advanced stages of disease and the morbidity related to therapeutic procedures are still a challenge. Innovations in the surgical treatment of solid tumors can contribute to increase the survival rate of affected children and to decrease the treatment-related morbidity. Considering these aspects, the successful implementation of innovations is described based on four examples...
March 2018: Der Chirurg; Zeitschrift Für Alle Gebiete der Operativen Medizen
https://www.readbyqxmd.com/read/29297619/a-framework-to-develop-adapted-treatment-regimens-to-manage-pediatric-cancer-in-low-and-middle-income-countries-the-pediatric-oncology-in-developing-countries-podc-committee-of-the-international-pediatric-oncology-society-siop
#14
Scott C Howard, Alan Davidson, Sandra Luna-Fineman, Trijn Israels, Guillermo Chantada, Catherine G Lam, Stephen P Hunger, Simon Bailey, Raul C Ribeiro, Ramandeep S Arora, Francisco Pedrosa, Mhamed Harif, Monika L Metzger
Many children with cancer in low- and middle-income countries are treated in hospitals lacking key infrastructure, including diagnostic capabilities, imaging modalities, treatment components, supportive care, and personnel. Childhood cancer treatment regimens adapted to local conditions provide an opportunity to cure as many children as possible with the available resources, while working to improve services and supportive care. This paper from the Adapted Treatment Regimens Working Group of the Pediatric Oncology in Developing Countries committee of the International Society of Pediatric Oncology outlines the design, development, implementation, and evaluation of adapted regimens and specifies levels of services needed to deliver them...
December 2017: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/29297618/siop-podc-adapted-treatment-guidelines-for-low-grade-gliomas-in-low-and-middle-income-settings
#15
Laila Hessissen, Jeannette Parkes, Nisreen Amayiri, Naureen Mushtaq, Nongnuch Sirachainan, Yavuz Anacak, Dipayan Mitra, Anthony Figaji, Antoinette Schouten-van Meeteren, Michael Sullivan, Hester Burger, Alan Davidson, Eric Bouffet, Simon Bailey
Effective treatment of children with low grade glioma (LGG) requires a functioning multi-disciplinary team with adequate neurosurgical, neuroradiological, pathological, radiotherapy and chemotherapy facilities and personnel. In addition, the treating centre should have the capacity to manage a variety of LGG and treatment-associated complications. These requirements have made it difficult for many centers in low and middle-income countries (LMIC) to offer effective treatment and follow up. This article provides management recommendations for children with LGG according to the level of facilities available...
December 2017: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/29297617/recommendations-for-the-treatment-of-children-with-radiotherapy-in-low-and-middle-income-countries-lmic-a-position-paper-from-the-pediatric-radiation-oncology-society-pros-lmic-and-pediatric-oncology-in-developing-countries-podc-working-groups-of-the-international
#16
Jeannette Parkes, Clayton Hess, Hester Burger, Yavuz Anacak, Verity Ahern, Scott C Howard, Moawia Elhassan, Soha Ahmed, Mithra Ghalibafian, Ahmed Nadeem Abbasi, Bilal Mazhar Qureshi, Mohamed Zaghloul, Eduardo Zubizarreta, Pierre Bey, Alan Davidson, Eric Bouffet, Natia Esiashvili
Pediatric radiotherapy is a critical part of pediatric oncology protocols and the quality of the radiotherapy may determine the future quality of life for long-term survivors. Multidisciplinary team decision making provides the basis for high-quality care. However, delivery of high-quality radiotherapy is dependent on resources. This article provides guidelines for delivery of good quality radiation therapy in resource-limited countries based on rational procurement and maintenance planning, protocol development, three-dimensional planning, quality assurance, and adequate staff numbers and training...
December 2017: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/29286563/etv6-ntrk3-in-congenital-mesoblastic-nephroma-a-report-of-the-siop-gpoh-nephroblastoma-study
#17
Christian Vokuhl, Nasenien Nourkami-Tutdibi, Rhoikos Furtwängler, Manfred Gessler, Norbert Graf, Ivo Leuschner
BACKGROUND: Congenital mesoblastic nephroma (MN) is a rare pediatric renal tumor representing approximately 5% of all pediatric renal tumors. Three different types of MN are distinguished histologically: classical, cellular, and mixed. A frequent genetic alteration is the translocation t(12;15) resulting in a fusion of the ETV6 gene on 12p13 and the NTRK3 gene on 15p15 that occurs almost exclusively in cellular MN. The aim of this study was to determine translocation status of a large cohort of MN with respect to tumor subtype and outcome...
April 2018: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/29246796/current-state-of-renal-tumor-surgery-among-pediatric-surgeons-and-pediatric-urologists-a-survey-of-american-pediatric-surgical-association-apsa-and-society-for-pediatric-urology-spu-members
#18
Nicholas G Cost, Jennifer H Aldrink, Amanda F Saltzman, Roshni Dasgupta, Kenneth W Gow, Richard Glick, Peter F Ehrlich
INTRODUCTION: Anecdotally, renal tumor (RT) surgery makes up a limited portion of the practice for most pediatric urologists and pediatric surgeons. Data are lacking on the current perceptions of RT surgery, both volume of surgery and issues related to surgical practice, among pediatric surgeons (PS) and pediatric urologists (PU). OBJECTIVES: To describe practice patterns of pediatric renal tumor (RT) surgery and identify factors related to higher reported volumes of RT surgery...
December 2, 2017: Journal of Pediatric Urology
https://www.readbyqxmd.com/read/29211298/prognostic-relevance-of-early-radiologic-response-to-induction-chemotherapy-in-pediatric-rhabdomyosarcoma-a-report-from-the-international-society-of-pediatric-oncology-malignant-mesenchymal-tumor-95-study
#19
Bas Vaarwerk, Johanna H van der Lee, Willemijn B Breunis, Daniel Orbach, Julia C Chisholm, Nathalie Cozic, Meriel Jenney, Rick R van Rijn, Kieran McHugh, Soledad Gallego, Heidi Glosli, Christine Devalck, Mark N Gaze, Anna Kelsey, Christophe Bergeron, Michael C G Stevens, Odile Oberlin, Veronique Minard-Colin, Johannes H M Merks
BACKGROUND: Early response to induction chemotherapy is used in current European guidelines to evaluate the efficacy of chemotherapy and subsequently to adapt treatment in pediatric patients with rhabdomyosarcoma (RMS). However, existing literature on the prognostic value of early radiologic response on survival is contradictory; here the prognostic value is analyzed with data from the International Society of Pediatric Oncology (SIOP) Malignant Mesenchymal Tumor 95 (MMT-95) study. METHODS: This study examined 432 Intergroup Rhabdomyosarcoma Study Grouping III (macroscopic residue) patients enrolled in the SIOP MMT-95 study with a response assessment after 3 courses of chemotherapy (a 2-dimensional assessment)...
March 1, 2018: Cancer
https://www.readbyqxmd.com/read/29140495/traditional-and-complementary-medicine-in-pediatric-oncology-and-low-middle-income-countries-recommendations-from-the-international-society-of-pediatric-oncology-siop-t-cm-collaborative
#20
Elena J Ladas, Stacey Marjerrison, Brijesh Arora, Peter B Hesseling, Roberta Ortiz, Federico Antillon, Shalini Jatia, Glenn M Afungchwi
Significant strides have been made in the treatment of childhood cancer. Improvements in survival have led to increased attention toward supportive care indications; including the use of traditional and complementary medicine (T&CM). The use of T&CM among children and adolescents with cancer is well documented in both high-income countries (HICs) and low-middle income countries (LMICs). A higher incidence of the use of T&CM has been reported among children undergoing treatment in LMICs, which has elevated concerns related to drug interactions, adherence to therapy, and treatment-related toxicities...
November 1, 2017: Journal of the National Cancer Institute. Monographs
keyword
keyword
27879
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"