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https://www.readbyqxmd.com/read/29140495/traditional-and-complementary-medicine-in-pediatric-oncology-and-low-middle-income-countries-recommendations-from-the-international-society-of-pediatric-oncology-siop-t-cm-collaborative
#1
Elena J Ladas, Stacey Marjerrison, Brijesh Arora, Peter B Hesseling, Roberta Ortiz, Federico Antillon, Shalini Jatia, Glenn M Afungchwi
Significant strides have been made in the treatment of childhood cancer. Improvements in survival have led to increased attention toward supportive care indications; including the use of traditional and complementary medicine (T&CM). The use of T&CM among children and adolescents with cancer is well documented in both high-income countries (HICs) and low-middle income countries (LMICs). A higher incidence of the use of T&CM has been reported among children undergoing treatment in LMICs, which has elevated concerns related to drug interactions, adherence to therapy, and treatment-related toxicities...
November 1, 2017: Journal of the National Cancer Institute. Monographs
https://www.readbyqxmd.com/read/29128947/t2-based-mr-imaging-gradient-echo-or-susceptibility-weighted-imaging-in-midline-and-off-midline-intracranial-germ-cell-tumors-a-pilot-study
#2
Giovanni Morana, Cesar Augusto Alves, Domenico Tortora, Jonathan L Finlay, Mariasavina Severino, Paolo Nozza, Marcello Ravegnani, Marco Pavanello, Claudia Milanaccio, Mohamad Maghnie, Andrea Rossi, Maria Luisa Garrè
PURPOSE: The role of T2*-based MR imaging in intracranial germ cell tumors (GCTs) has not been fully elucidated. The aim of this study was to evaluate the susceptibility-weighted imaging (SWI) or T2* gradient echo (GRE) features of germinomas and non-germinomatous germ cell tumors (NGGCTs) in midline and off-midline locations. METHODS: We retrospectively evaluated all consecutive pediatric patients referred to our institution between 2005 and 2016, for newly diagnosed, treatment-naïve intracranial GCT, who underwent MRI, including T2*-based MR imaging (T2* GRE sequences or SWI)...
November 11, 2017: Neuroradiology
https://www.readbyqxmd.com/read/29089605/position-paper-rationale-for-the-treatment-of-wilms-tumour-in-the-umbrella-siop-rtsg-2016-protocol
#3
REVIEW
Marry M van den Heuvel-Eibrink, Janna A Hol, Kathy Pritchard-Jones, Harm van Tinteren, Rhoikos Furtwängler, Arnauld C Verschuur, Gordan M Vujanic, Ivo Leuschner, Jesper Brok, Christian Rübe, Anne M Smets, Geert O Janssens, Jan Godzinski, Gema L Ramírez-Villar, Beatriz de Camargo, Heidi Segers, Paola Collini, Manfred Gessler, Christophe Bergeron, Filippo Spreafico, Norbert Graf
The Renal Tumour Study Group of the International Society of Paediatric Oncology (SIOP-RTSG) has developed a new protocol for the diagnosis and treatment of childhood renal tumours, the UMBRELLA SIOP-RTSG 2016 (the UMBRELLA protocol), to continue international collaboration in the treatment of childhood renal tumours. This protocol will support integrated biomarker and imaging research, focussing on assessing the independent prognostic value of genomic changes within the tumour and the volume of the blastemal component that survives preoperative chemotherapy...
October 31, 2017: Nature Reviews. Urology
https://www.readbyqxmd.com/read/29077255/irinotecan-for-relapsed-wilms-tumor-in-pediatric-patients-siop-experience-and-review-of-the-literature-a-report-from-the-siop-renal-tumor-study-group
#4
Janna A Hol, Marry M van den Heuvel-Eibrink, Norbert Graf, Kathy Pritchard-Jones, Jesper Brok, Harm van Tinteren, Lisa Howell, Arnauld Verschuur, Christophe Bergeron, Leo Kager, Serena Catania, Filippo Spreafico, Annelies M C Mavinkurve-Groothuis
While irinotecan has been studied in various pediatric solid tumors, its potential role in Wilms tumor (WT) is less clear. We evaluated response and outcome of irinotecan-containing regimens in relapsed WT and compared our results to the available literature. Among 14 evaluable patients, one complete response (CR) and two partial responses (PRs) were observed in patients with initial intermediate-risk (CR and PR) and blastemal-type histologies (PR). Two patients were alive at last follow-up showing no evidence of disease...
October 27, 2017: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/29071540/current-and-emerging-treatment-strategies-for-children-with-progressive-chiasmatic-hypothalamic-glioma-diagnosed-as-infants-a-web-based-survey
#5
Amedeo A Azizi, Antoinette Y N Schouten-van Meeteren
Treatment of infant hypothalamic chiasmatic glioma (iCHG) is challenging, about 30% of the children progress during chemotherapy. Despite subsequent treatments the 5 year overall-survival rate is only 70%. This study investigates treatment strategies currently applied for progressive iCHG. A web-based questionnaire was sent out to the members of the SIOPE Brain Tumour Group asking for current second and third line strategies at progression during and after the end of first line therapy. The questionnaire was answered by 47 paediatric oncologists from 15 countries...
October 25, 2017: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/29066008/49th-siop-congress
#6
Allison Landman
No abstract text is available yet for this article.
October 20, 2017: Lancet Oncology
https://www.readbyqxmd.com/read/29048505/outcome-of-patients-with-intracranial-non-germinomatous-germ-cell-tumors-lessons-from-the-siop-cns-gct-96-trial
#7
Gabriele Calaminus, Didier Frappaz, Rolf Dieter Kortmann, Barbara Krefeld, Frank Saran, Torsten Pietsch, Alexandre Vasiljevic, Maria Luisa Garre, Umberto Ricardi, Jillian R Mann, Ulrich Göbel, Claire Alapetite, Matthew J Murray, James C Nicholson
Background: Following promising results to increase survival and reduce treatment burden in intracranial non-germinomatous germ cell tumors (NGGCTs), we conducted a European study using dose-intense chemotherapy followed by risk-adapted radiotherapy. Methods: All patients received 4 courses of cisplatin/etoposide/ifosfamide. Non-metastatic patients then received focal radiotherapy only (54 Gy); metastatic patients received 30 Gy craniospinal radiotherapy with 24 Gy boost to primary tumor and macroscopic metastatic sites...
July 5, 2017: Neuro-oncology
https://www.readbyqxmd.com/read/29018578/the-care-of-adolescents-and-young-adults-with-cancer-results-of-the-esmo-siope-survey
#8
Emmanouil Saloustros, Daniel P Stark, Kyriaki Michailidou, Giannis Mountzios, Laurence Brugieres, Fedro Alessandro Peccatori, Svetlana Jezdic, Samira Essiaf, Jean-Yves Douillard, Stefan Bielack
INTRODUCTION: Adolescents and young adults (AYA) with cancer require dedicated clinical management and care. Little is known about the training and practice of European healthcare providers in regard to AYA and the availability of specialised services. METHODS: A link to an online survey was sent to members of the European Society for Medical Oncology (ESMO) and the European Society for Paediatric Oncology (SIOPE). The link was also sent to ESMO National Representatives and circulated to other European oncology groups...
2017: ESMO Open
https://www.readbyqxmd.com/read/29016183/paul-w-thayer-1927-2017
#9
Michael A Campion
Presents an obituary for Paul W. Thayer, who died on January 25, 2017, at the age of 89. Thayer was an industrial and organizational psychologist probably most distinguished by his professional service. He was a fellow of the American Psychological Association (APA), American Psychological Society (APS), and Society for Industrial and Organizational Psychology (SIOP). He received multiple awards for his service, including SIOP's Distinguished Professional Contributions Award (1986) and its Distinguished Service Award (1990), as well as the APA Award for Distinguished Service to Psychological Science (2014)...
October 2017: American Psychologist
https://www.readbyqxmd.com/read/28863244/abstracts-from-the-49th-congress-of-the-international-society-of-paediatric-oncology-siop-washington-dc-usa-october-12-15-2017
#10
(no author information available yet)
No abstract text is available yet for this article.
November 2017: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/28843054/high-dose-treatment-for-malignant-rhabdoid-tumor-of-the-kidney-no-evidence-for-improved-survival-the-gesellschaft-f%C3%A3-r-p%C3%A3-diatrische-onkologie-und-h%C3%A3-matologie-gpoh-experience
#11
Rhoikos Furtwängler, Leo Kager, Patrick Melchior, Christian Rübe, Martin Ebinger, Nasenien Nourkami-Tutdibi, Felix Niggli, Steven Warmann, Jochen Hubertus, Gabriele Amman, Ivo Leuschner, Christian Vokuhl, Norbert Graf, Michael C Frühwald
BACKGROUND: Malignant rhabdoid tumor of the kidney (MRTK) is the most aggressive childhood renal tumor with overall survival (OS) rates ranging from 22% to 42%. Whether high-dose chemotherapy with autologous stem-cell transplantation (HDSCT) in an intensive first-line treatment offers additional benefit is an ongoing discussion. METHODS: A retrospective analysis of all 58 patients with MRTK from Austria, Switzerland, and Germany treated in the framework of consecutive, prospective renal/rhabdoid tumor studies SIOP9/GPO, SIOP93-01/GPOH (where SIOP is International Society of Pediatric Oncology and GPOH is German Society of Pediatric Oncology and Hematology), SIOP2001/GPOH, and European Rhabdoid Tumor Registry from 1991 to 2014...
August 26, 2017: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/28830607/partnership-of-the-sociedade-brasileira-de-oncologia-pedi%C3%A3-trica-and-international-society-of-pediatric-oncology-to-improve-nutritional-care-for-children-with-cancer-in-brazil
#12
Karina Viani, Vicente Odone Filho, Sima Ferman, Teresa Cristina Cardoso Fonseca, Vanessa da Cunha Oliveira, Priscila Dos Santos Maia Lemos, Ronald D Barr, Elena J Ladas
The authors present a proposal of a partnership between the Sociedade Brasileira de Oncologia Pediátrica (SOBOPE) and the International Society of Pediatric Oncology (SIOP) to promote the standardization and improvement of nutritional care of kids under cancer treatment in Brazil. The results of the first meeting in Brazil as well as plans for future meetings are described.
July 2017: Revista Brasileira de Hematologia e Hemoterapia
https://www.readbyqxmd.com/read/28649001/a-european-randomised-controlled-trial-of-the-addition-of-etoposide-to-standard-vincristine-and-carboplatin-induction-as-part-of-an-18-month-treatment-programme-for-childhood-%C3%A2-16%C3%A2-years-low-grade-glioma%C3%A2-a-final-report
#13
RANDOMIZED CONTROLLED TRIAL
Astrid K Gnekow, David A Walker, Daniela Kandels, Susan Picton, Giorgio Perilongo, Jacques Grill, Tore Stokland, Per Eric Sandstrom, Monika Warmuth-Metz, Torsten Pietsch, Felice Giangaspero, René Schmidt, Andreas Faldum, Denise Kilmartin, Angela De Paoli, Gian Luca De Salvo
BACKGROUND: The use of chemotherapy to manage newly diagnosed low grade glioma (LGG) was first introduced in the 1980s. One randomised trial has studied two- versus four-drug regimens with a duration of 12 months of treatment after resection. METHODS: Within the European comprehensive treatment strategy for childhood LGG, the International Society of Paediatric Oncology-Low Grade Glioma (SIOP LGG) Committee launched a randomised trial involving 118 institutions and 11 countries to investigate the addition of etoposide (100 mg/m(2), days 1, 2 & 3) to a four-course induction of vincristine (1...
August 2017: European Journal of Cancer
https://www.readbyqxmd.com/read/28617804/integrating-tenascin-c-protein-expression-and-1q25-copy-number-status-in-pediatric-intracranial-ependymoma-prognostication-a-new-model-for-risk-stratification
#14
MULTICENTER STUDY
Felipe Andreiuolo, Gwénaël Le Teuff, Mohamed Amine Bayar, John-Paul Kilday, Torsten Pietsch, André O von Bueren, Hendrik Witt, Andrey Korshunov, Piergiorgio Modena, Stefan M Pfister, Mélanie Pagès, David Castel, Felice Giangaspero, Leila Chimelli, Pascale Varlet, Stefan Rutkowski, Didier Frappaz, Maura Massimino, Richard Grundy, Jacques Grill
PURPOSE: Despite multimodal therapy, prognosis of pediatric intracranial ependymomas remains poor with a 5-year survival rate below 70% and frequent late deaths. EXPERIMENTAL DESIGN: This multicentric European study evaluated putative prognostic biomarkers. Tenascin-C (TNC) immunohistochemical expression and copy number status of 1q25 were retained for a pooled analysis of 5 independent cohorts. The prognostic value of TNC and 1q25 on the overall survival (OS) was assessed using a Cox model adjusted to age at diagnosis, tumor location, WHO grade, extent of resection, radiotherapy and stratified by cohort...
2017: PloS One
https://www.readbyqxmd.com/read/28614497/fiscal-responsibility-law-and-expenditure-on-health-personnel-an-analysis-of-the-condition-of-brazilian-municipalities-from-2004-to-2009
#15
Katia Rejane de Medeiros, Paulette Cavalcanti de Albuquerque, Ricardo Antônio Wanderley Tavares, Wayner Vieira de Souza
The limits for expenditure on personnel that were imposed by the Fiscal Responsibility Act (FRA) have been considered by local health managers as an obstacle to health sector policies. This paper analyzes the linear trend for the personnel expenses indicators and the correlation of this with the profile of spending on health care personnel in 5,356 Brazilian municipalities from 2004 to 2009. The study of the time series used data from the 'Finanças do Brasil' (Finbra) and data from the Information System on Public Health Budgets (SIOPS)...
June 2017: Ciência & Saúde Coletiva
https://www.readbyqxmd.com/read/28560664/external-validation-of-the-diffuse-intrinsic-pontine-glioma-survival-prediction-model-a-collaborative-report-from-the-international-dipg-registry-and-the-siope-dipg-registry
#16
Sophie E M Veldhuijzen van Zanten, Adam Lane, Martijn W Heymans, Joshua Baugh, Brooklyn Chaney, Lindsey M Hoffman, Renee Doughman, Marc H A Jansen, Esther Sanchez, William P Vandertop, Gertjan J L Kaspers, Dannis G van Vuurden, Maryam Fouladi, Blaise V Jones, James Leach
We aimed to perform external validation of the recently developed survival prediction model for diffuse intrinsic pontine glioma (DIPG), and discuss its utility. The DIPG survival prediction model was developed in a cohort of patients from the Netherlands, United Kingdom and Germany, registered in the SIOPE DIPG Registry, and includes age <3 years, longer symptom duration and receipt of chemotherapy as favorable predictors, and presence of ring-enhancement on MRI as unfavorable predictor. Model performance was evaluated by analyzing the discrimination and calibration abilities...
August 2017: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/28545823/novel-molecular-subgroups-for-clinical-classification-and-outcome-prediction-in-childhood-medulloblastoma-a-cohort-study
#17
Edward C Schwalbe, Janet C Lindsey, Sirintra Nakjang, Stephen Crosier, Amanda J Smith, Debbie Hicks, Gholamreza Rafiee, Rebecca M Hill, Alice Iliasova, Thomas Stone, Barry Pizer, Antony Michalski, Abhijit Joshi, Stephen B Wharton, Thomas S Jacques, Simon Bailey, Daniel Williamson, Steven C Clifford
BACKGROUND: International consensus recognises four medulloblastoma molecular subgroups: WNT (MBWNT), SHH (MBSHH), group 3 (MBGrp3), and group 4 (MBGrp4), each defined by their characteristic genome-wide transcriptomic and DNA methylomic profiles. These subgroups have distinct clinicopathological and molecular features, and underpin current disease subclassification and initial subgroup-directed therapies that are underway in clinical trials. However, substantial biological heterogeneity and differences in survival are apparent within each subgroup, which remain to be resolved...
July 2017: Lancet Oncology
https://www.readbyqxmd.com/read/28499018/intracystic-interferon-alpha-in-pediatric-craniopharyngioma-patients-an-international-multicenter-assessment-on-behalf-of-siope-and-ispn
#18
John-Paul Kilday, Massimo Caldarelli, Luca Massimi, Robert Hsin-Hung Chen, Yi Yen Lee, Muh-Lii Liang, Jeanette Parkes, Thuran Naiker, Marie-Lise van Veelen, Erna Michiels, Conor Mallucci, Benedetta Pettorini, Lisethe Meijer, Christian Dorfer, Thomas Czech, Manuel Diezi, Antoinette Y N Schouten-van Meeteren, Stefan Holm, Bengt Gustavsson, Martin Benesch, Hermann L Müller, Anika Hoffmann, Stefan Rutkowski, Joerg Flitsch, Gabriele Escherich, Michael Grotzer, Helen A Spoudeas, Kristian Azquikina, Michael Capra, Rolando Jiménez-Guerra, Patrick MacDonald, Donna L Johnston, Rina Dvir, Shlomi Constantini, Meng-Fai Kuo, Shih-Hung Yang, Ute Bartels
Background: Craniopharyngiomas are frequent hypothalamo-pituitary tumors in children, presenting predominantly as cystic lesions. Morbidity from conventional treatment has focused attention on intracystic drug delivery, hypothesized to cause fewer clinical consequences. However, the efficacy of intracystic therapy remains unclear. We report the retrospective experiences of several global centers using intracystic interferon-alpha. Methods: European Société Internationale d'Oncologie Pédiatrique and International Society for Pediatric Neurosurgery centers were contacted to submit a datasheet capturing pediatric patients with cystic craniopharyngiomas who had received intracystic interferon-alpha...
October 1, 2017: Neuro-oncology
https://www.readbyqxmd.com/read/28463506/locating-reactive-groups-on-nanomaterials-with-gold-nanoclusters-toward-a-surface-reactive-site-map
#19
Steffi S Thomas, Matthew Coleman, Emma Carroll, Ester Polo, Fabian Meder, Kenneth A Dawson
Nanoparticles (NPs) are often functionalized with reactive groups such as amines and thiols for the subsequent conjugation of further molecules, e.g., stabilizing polymers, drugs, and proteins for targeting cells or specific diseases. In addition to the quantitative estimation of the reactive conjugation sites, their molecular positioning and nanoscale arrangement on single nanoparticles become more and more important for the tailored engineering and design of functional nanomaterials. Here, we use maleimide or sulfo-succinimidyl ester-modified 1...
May 8, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28463397/treatment-and-outcomes-of-uk-and-german-patients-with-relapsed-intracranial-germ-cell-tumors-following-uniform-first-line-therapy
#20
Matthew J Murray, Shivani Bailey, Katja Heinemann, Jillian Mann, Ulrich K Göbel, Frank Saran, Juliet P Hale, Gabriele Calaminus, James C Nicholson
We aimed to retrospectively assess treatments/outcomes, including the value of high-dose-chemotherapy and autologous-stem-cell-rescue (HDC + AuSCR) and re-irradiation, in a large, European patient-cohort with relapsed intracranial germ-cell-tumors (GCTs) receiving uniform first-line therapy, including radiotherapy as standard-of-care. Fifty-eight UK/German patients (48 male/10 female) with relapsed intracranial-GCTs [13 germinoma/45 non-germinomatous GCT (NGGCT)] treated 1996-2010 as per the SIOP-CNS-GCT-96 protocol were evaluated...
August 1, 2017: International Journal of Cancer. Journal International du Cancer
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