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https://www.readbyqxmd.com/read/27922041/paediatric-renal-tumours-perspectives-from-the-siop-rtsg
#1
(no author information available yet)
The >90% rates of overall survival for children with Wilms tumour are remarkable and have been achieved at the same time as reducing treatment for most patients. However, beneath this headline figure, 20% of patients still relapse after first-line therapy and up to 25% of survivors report severe late effects. The aim of the SIOP-RTSG is to improve outcomes and to reduce acute and late treatment toxic effects in all children.
December 6, 2016: Nature Reviews. Urology
https://www.readbyqxmd.com/read/27898175/interventions-for-promoting-participation-in-shared-decision-making-for-children-with-cancer
#2
REVIEW
Imelda Coyne, Dónal P O'Mathúna, Faith Gibson, Linda Shields, Edith Leclercq, Greg Sheaf
BACKGROUND: This is an update of the Cochrane systematic review of shared decision-making (SMD) making published in 2013. Children's rights to have their views heard in matters that affect their lives are now well established since the publication of the UN Convention treaty (1989). Children with cancer generally prefer to be involved in decision-making and consider it important that they have the opportunity to take part in decision-making concerning their health care, even in end-of-life decisions...
November 29, 2016: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/27866682/-adolescent-and-young-adults-ayas-brain-tumor-national-web-conference-on-behalf-of-anocef-go-aja-and-sfce-societies
#3
Didier Frappaz, Marie-Pierre Sunyach, Emilie Le Rhun, Marie Blonski, Valérie Laurence, Alice Bonneville Levard, Hugues Loiseau, David Meyronnet, Arnaud Callies, F Laigle-Donadey, Cecile Faure Conter
: The skills of adult versus pediatric neuro-oncologists are not completely similar though additive. Because the tumors and their protocols are different and the tolerance and expected sequelae are specific. Multidisciplinary meetings including adult and pediatric neuro-oncologists are warranted to share expertise. Since 2008, a weekly national web based conference was held in France. Any patient with the following criteria could be discussed: Adolescent and Young Adults aged between 15 and 25 years, and any adult with a pediatric type pathology, including medulloblastoma, germ cell tumors, embryonic tumors, ependymoma, pilocytic astrocytoma...
November 17, 2016: Bulletin du Cancer
https://www.readbyqxmd.com/read/27799929/the-high-prevalence-of-functional-complement-defects-induced-by-chemotherapy
#4
Mischa P Keizer, Angela M Kamp, Cathelijn Aarts, Judy Geisler, Huib N Caron, Marianne D van de Wetering, Diana Wouters, Taco W Kuijpers
INTRODUCTION: To date, oncology patients are more dependent on non-cellular host defense against pathogens due to intensive (chemo)therapy-related bone marrow suppression. Since data on complement functionality in oncology patients are limited, we aimed to investigate the innate complement function in relation to the type of malignancy and therapy in a longitudinal cohort of patients. METHODS: A large single-center, prospective non-intervention study was conducted, in which blood samples were taken from patients before, during, and after treatment with chemotherapy and/or subsequent admittance for (febrile) neutropenia...
2016: Frontiers in Immunology
https://www.readbyqxmd.com/read/27726252/whole-tumor-apparent-diffusion-coefficient-measurements-in-nephroblastoma-can-it-identify-blastemal-predominance
#5
Annemieke S Littooij, Neil J Sebire, Øystein E Olsen
PURPOSE: To explore the potential relation between whole-tumor apparent diffusion coefficient (ADC) parameters in viable parts of tumor and histopathological findings in nephroblastoma. MATERIALS AND METHODS: Children (n = 52) with histopathologically proven nephroblastoma underwent diffusion-weighted magnetic resonance imaging (MRI) (1.5T) before preoperative chemotherapy. Of these, 25 underwent an additional MRI after preoperative chemotherapy, shortly before resection...
October 11, 2016: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/27717499/-pediatric-ependymomas-current-diagnosis-and-therapy
#6
Didier Frappaz, Alexandre Vasiljevic, Pierre-Aurelien Beuriat, Claire Alapetite, Jacques Grill, Alexandru Szathmari, Cécile Faure-Conter
Ependymomas represent 10% of pediatric brain tumors. In the recent WHO 2016 classification, pathology is enriched by localization and molecular biology. Whatever the age, total removal by one or several looks when required remains a major prognostic factor. In children, focal radiation remains a standard, while the role of chemotherapy is matter of randomized studies. In infants, front line chemotherapy is the standard. Inclusion in the SIOP ependymoma II protocol is encouraged. In case of relapse, further surgery and radiation are advised, while inclusion in innovative trials including re-irradiation, and phase I-II should be encouraged...
October 2016: Bulletin du Cancer
https://www.readbyqxmd.com/read/27673274/abstracts-from-the-48-th-congress-of-the-international-society-of-paediatric-oncology-siop-dublin-ireland-october-19-22-2016
#7
(no author information available yet)
No abstract text is available yet for this article.
November 2016: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/27595352/epidemiology-of-adolescents-and-young-adults-with-cancer-in-europe
#8
Emmanuel Desandes, Daniel P Stark
To design the services for adolescents and young adults (AYAs) with cancer, we need to understand the patterns of disease and the other clinical and managerial challenges of the patient group. Cancer occurring between the ages of 15 and 39 years is 4 times less rare than cancer occurring during the first 15 years of life and consists of 2% of all invasive cancer in Europe, about 66,000 patients in Europe each year. AYAs have a unique distribution of cancer types, including the peak in incidence of Hodgkin lymphoma (HL) or germ cell tumors...
2016: Progress in Tumor Research
https://www.readbyqxmd.com/read/27585992/assessing-second-look-tumour-resectability-in-childhood-posterior-fossa-ependymoma-a-centralised-review-panel-and-staging-tool-for-future-studies
#9
Christopher P Millward, Conor Mallucci, Tim Jaspan, Donald Macarthur, Richard Heyward, Tim Cox, Kung Chong, Richard G Grundy
PURPOSE: To improve uniformity in radiological review/reporting and discussion of surgical resection status in the forthcoming SIOP Ependymoma II trial, a central review of imaging and resection status will be carried out prior to treatment stratification. We present a review of surgical decision-making from the UKCCSG/SIOP Ependymoma trial for very young children (<3 years) (Lancet Oncol 8:696-705, 2007) and propose a primary surgical staging system for residual disease that could be used for Ependymoma II...
September 1, 2016: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://www.readbyqxmd.com/read/27571534/james-l-outtz-1947-2016
#10
Sheldon Zedeck, Wayne Cascio
This article memorializes James L. Outtz, who passed away March 26, 2016. For more than 40 years, Outtz was a leading researcher, practitioner, and consultant in the areas of hiring and promotion, employment discrimination, selection-test design and implementation, and legal issues pertaining to employment. He worked tirelessly to enhance opportunities for workforce diversity through greater inclusion of minorities and women. Another important focus was on strategies to minimize adverse impact through alternative approaches to selection...
September 2016: American Psychologist
https://www.readbyqxmd.com/read/27552363/medical-interventions-for-treating-anthracycline-induced-symptomatic-and-asymptomatic-cardiotoxicity-during-and-after-treatment-for-childhood-cancer
#11
REVIEW
Daniel K L Cheuk, Elske Sieswerda, Elvira C van Dalen, Aleida Postma, Leontien C M Kremer
BACKGROUND: Anthracyclines are frequently used chemotherapeutic agents for childhood cancer that can cause cardiotoxicity during and after treatment. Although several medical interventions in adults with symptomatic or asymptomatic cardiac dysfunction due to other causes are beneficial, it is not known if the same treatments are effective for childhood cancer patients and survivors with anthracycline-induced cardiotoxicity. This review is an update of a previously published Cochrane review...
2016: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/27459057/nonparameningeal-head-and-neck-rhabdomyosarcoma-in-children-and-adolescents-lessons-from-the-consecutive-international-society-of-pediatric-oncology-malignant-mesenchymal-tumor-studies
#12
Daniel Orbach, Veronique Mosseri, Soledad Gallego, Anna Kelsey, Christine Devalck, Bernadette Brenann, Max M van Noesel, Christophe Bergeron, Johannes H M Merks, Catherine Rechnitzer, Meriel Jenney, Veronique Minard-Colin, Michael Stevens
BACKGROUND: This article reports risk factors and long-term outcome in localized nonparameningeal head and neck rhabdomyosarcomas in children and adolescents from a combined dataset from 3 consecutive international trials. METHODS: Data from 140 children (9.3% of total) prospectively enrolled in the International Society of Pediatric Oncology Malignant Mesenchymal Tumor (SIOP-MMT)-84/89/95 studies were analyzed. RESULTS: Primary site was: superficial face in 46%; oral cavity (21%); neck (19%); and salivary glands (14%)...
July 26, 2016: Head & Neck
https://www.readbyqxmd.com/read/27432915/gain-of-1q-as-a-prognostic-biomarker-in-wilms-tumors-wts-treated-with-preoperative-chemotherapy-in-the-international-society-of-paediatric-oncology-siop-wt-2001-trial-a-siop-renal-tumours-biology-consortium-study
#13
Tasnim Chagtai, Christina Zill, Linda Dainese, Jenny Wegert, Suvi Savola, Sergey Popov, William Mifsud, Gordan Vujanić, Neil Sebire, Yves Le Bouc, Peter F Ambros, Leo Kager, Maureen J O'Sullivan, Annick Blaise, Christophe Bergeron, Linda Holmquist Mengelbier, David Gisselsson, Marcel Kool, Godelieve A M Tytgat, Marry M van den Heuvel-Eibrink, Norbert Graf, Harm van Tinteren, Aurore Coulomb, Manfred Gessler, Richard Dafydd Williams, Kathy Pritchard-Jones
PURPOSE: Wilms tumor (WT) is the most common pediatric renal tumor. Treatment planning under International Society of Paediatric Oncology (SIOP) protocols is based on staging and histologic assessment of response to preoperative chemotherapy. Despite high overall survival (OS), many relapses occur in patients without specific risk factors, and many successfully treated patients are exposed to treatments with significant risks of late effects. To investigate whether molecular biomarkers could improve risk stratification, we assessed 1q status and other potential copy number biomarkers in a large WT series...
September 10, 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/27423645/relapse-patterns-and-outcome-after-relapse-in-standard-risk-medulloblastoma-a-report-from-the-hit-siop-pnet4-study
#14
Magnus Sabel, Gudrun Fleischhack, Stephan Tippelt, Göran Gustafsson, François Doz, Rolf Kortmann, Maura Massimino, Aurora Navajas, Katja von Hoff, Stefan Rutkowski, Monika Warmuth-Metz, Steven C Clifford, Torsten Pietsch, Barry Pizer, Birgitta Lannering
The HIT-SIOP-PNET4 randomised trial for standard risk medulloblastoma (MB) (2001-2006) included 338 patients and compared hyperfractionated and conventional radiotherapy. We here report the long-term outcome after a median follow up of 7.8 years, including detailed information on relapse and the treatment of relapse. Data were extracted from the HIT Group Relapsed MB database and by way of a specific case report form. The event-free and overall (OS) survival at 10 years were 76 ± 2 % and 78 ± 2 % respectively with no significant difference between the treatment arms...
September 2016: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/27388894/occupational-prestige-social-mobility-and-the-association-with-lung-cancer-in-men
#15
Thomas Behrens, Isabelle Groß, Jack Siemiatycki, David I Conway, Ann Olsson, Isabelle Stücker, Florence Guida, Karl-Heinz Jöckel, Hermann Pohlabeln, Wolfgang Ahrens, Irene Brüske, Heinz-Erich Wichmann, Per Gustavsson, Dario Consonni, Franco Merletti, Lorenzo Richiardi, Lorenzo Simonato, Cristina Fortes, Marie-Elise Parent, John McLaughlin, Paul Demers, Maria Teresa Landi, Neil Caporaso, David Zaridze, Neonila Szeszenia-Dabrowska, Peter Rudnai, Jolanta Lissowska, Eleonora Fabianova, Adonina Tardón, John K Field, Rodica Stanescu Dumitru, Vladimir Bencko, Lenka Foretova, Vladimir Janout, Hans Kromhout, Roel Vermeulen, Paolo Boffetta, Kurt Straif, Joachim Schüz, Jan Hovanec, Benjamin Kendzia, Beate Pesch, Thomas Brüning
BACKGROUND: The nature of the association between occupational social prestige, social mobility, and risk of lung cancer remains uncertain. Using data from the international pooled SYNERGY case-control study, we studied the association between lung cancer and the level of time-weighted average occupational social prestige as well as its lifetime trajectory. METHODS: We included 11,433 male cases and 14,147 male control subjects. Each job was translated into an occupational social prestige score by applying Treiman's Standard International Occupational Prestige Scale (SIOPS)...
2016: BMC Cancer
https://www.readbyqxmd.com/read/27388196/case-report-xanthogranulomutous-pyelonephritis-presenting-as-wilms-tumor
#16
Shakilu Iumanne, Aika Shoo, Larry Akoko, Patricia Scanlan
BACKGROUND: Xanthogranulomatous pyelonephritis (XGP) is a rare renal tumor that arises as a complication of chronic obstructive pyelonephritis of uncertain etiology. It is primarily an adult tumor seen occasionally in children associated with urinary tract obstruction due to congenital urological anomalies, nephrolithiasis, and recurrent urinary tract infections. Radiologically, it may show neoplastic features such as those seen in common pediatric renal malignancies like wilms' tumor and renal cell carcinoma...
July 7, 2016: BMC Urology
https://www.readbyqxmd.com/read/27379530/outcome-of-nephroblastoma-treatment-according-to-the-siop-2001-strategy-at-a-single-institution-in-argentina
#17
Constanza Cafferata, Walter Cacciavillano, María L Galluzzo, Paula Flores, Adriana Rose, Pedro Zubizarreta
OBJECTIVE: Wilms tumor (WT) is a disease with a good prognosis. The aim of this study was to evaluate the outcome of patients with WT, treated according to the SIOP-2001 strategy. METHODS: A retrospective analysis of 141 consecutive patients with WT diagnosed at our institution between December 2001 and 2013 was performed. RESULTS: A total of 114 patients, median age 38.8 months (3 to 155 mo), were assessable for analysis. Fine-needle aspiration was initially performed in 88 patients (84...
July 1, 2016: Journal of Pediatric Hematology/oncology
https://www.readbyqxmd.com/read/27378212/radiotherapy-for-diffuse-brainstem-glioma-in-children-and-young-adults
#18
REVIEW
Xin Hu, Yuan Fang, Xuhui Hui, Yan Jv, Chao You
BACKGROUND: Diffuse brainstem glioma is a devastating disease with very poor prognosis. The most commonly used radiological treatment is conventional fractionated radiation. So far, there is no meta-analysis or systematic review available that assesses the benefits or harms of radiation in people with diffuse brainstem glioma. OBJECTIVES: To assess the effects of conventional fractionated radiotherapy (with or without chemotherapy) versus other therapies (including different radiotherapy techniques) for newly diagnosed diffuse brainstem gliomas in children and young adults aged 0 to 21 years...
2016: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/27239162/barriers-to-timely-treatment-seeking-in-patients-with-acute-myocardial-infarction-in-malaysia-a-qualitative-study
#19
Li S Chai, Zabidah Putit, Sidiah Siop
BACKGROUND: Persisting delay in seeking treatment among Acute Myocardial Infarction (AMI) patients was reported in Malaysia despite intensified efforts in educating the public on symptoms of AMI and the importance of seeking prompt treatment. Studies outside Malaysia have shown that patients' personal thoughts during symptom onset could contribute to the delay. The purpose of this study is to explore the barriers of AMI patients prior to the decision of seeking treatment in Malaysia. METHODS: A qualitative descriptive research approach was chosen...
2016: BMC Nursing
https://www.readbyqxmd.com/read/27228957/is-nephron-sparing-surgery-justified-in-wilms-tumor-with-beckwith-wiedemann-syndrome-or-isolated-hemihypertrophy
#20
Aurélien Scalabre, Christophe Bergeron, Frederic Brioude, Linda Dainese, Claire Cropet, Aurore Coulomb L'hermine, Claudia Pasqualini, Frederic Auber, Arnauld Verschuur, Gudrun Schleiermacher, Yves Le Bouc, Georges Audry, Sabine Irtan
BACKGROUND: Patients with Beckwith-Wiedemann syndrome (BWS) or isolated hemihypertrophy (HH) treated for a Wilms tumor (WT) carry an increased risk of developing metachronous lesion. There are no guidelines on precise indications for nephron sparing surgery (NSS) in unilateral WT (UWT). The objective of this retrospective study was to delineate the indications of NSS in patients with BWS/HH treated for WT and to evaluate their outcome. PROCEDURE: All cases of BWS/HH treated for a WT according to SIOP protocols from 1980 to 2013 were reviewed...
September 2016: Pediatric Blood & Cancer
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