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https://www.readbyqxmd.com/read/29318365/-innovations-in-surgical-treatment-of-pediatric-solid-tumors
#1
REVIEW
A Schmidt, S W Warmann, C Urla, J Fuchs
The overall survival of children with solid tumors has shown a substantial increase in the past decades due to progress in all of the disciplines involved in the treatment. The poor prognosis for advanced stages of disease and the morbidity related to therapeutic procedures are still a challenge. Innovations in the surgical treatment of solid tumors can contribute to increase the survival rate of affected children and to decrease the treatment-related morbidity. Considering these aspects, the successful implementation of innovations is described based on four examples...
January 9, 2018: Der Chirurg; Zeitschrift Für Alle Gebiete der Operativen Medizen
https://www.readbyqxmd.com/read/29297619/a-framework-to-develop-adapted-treatment-regimens-to-manage-pediatric-cancer-in-low-and-middle-income-countries-the-pediatric-oncology-in-developing-countries-podc-committee-of-the-international-pediatric-oncology-society-siop
#2
Scott C Howard, Alan Davidson, Sandra Luna-Fineman, Trijn Israels, Guillermo Chantada, Catherine G Lam, Stephen P Hunger, Simon Bailey, Raul C Ribeiro, Ramandeep S Arora, Francisco Pedrosa, Mhamed Harif, Monika L Metzger
Many children with cancer in low- and middle-income countries are treated in hospitals lacking key infrastructure, including diagnostic capabilities, imaging modalities, treatment components, supportive care, and personnel. Childhood cancer treatment regimens adapted to local conditions provide an opportunity to cure as many children as possible with the available resources, while working to improve services and supportive care. This paper from the Adapted Treatment Regimens Working Group of the Pediatric Oncology in Developing Countries committee of the International Society of Pediatric Oncology outlines the design, development, implementation, and evaluation of adapted regimens and specifies levels of services needed to deliver them...
December 2017: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/29297618/siop-podc-adapted-treatment-guidelines-for-low-grade-gliomas-in-low-and-middle-income-settings
#3
Laila Hessissen, Jeannette Parkes, Nisreen Amayiri, Naureen Mushtaq, Nongnuch Sirachainan, Yavuz Anacak, Dipayan Mitra, Anthony Figaji, Antoinette Schouten-van Meeteren, Michael Sullivan, Hester Burger, Alan Davidson, Eric Bouffet, Simon Bailey
Effective treatment of children with low grade glioma (LGG) requires a functioning multi-disciplinary team with adequate neurosurgical, neuroradiological, pathological, radiotherapy and chemotherapy facilities and personnel. In addition, the treating centre should have the capacity to manage a variety of LGG and treatment-associated complications. These requirements have made it difficult for many centers in low and middle-income countries (LMIC) to offer effective treatment and follow up. This article provides management recommendations for children with LGG according to the level of facilities available...
December 2017: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/29297617/recommendations-for-the-treatment-of-children-with-radiotherapy-in-low-and-middle-income-countries-lmic-a-position-paper-from-the-pediatric-radiation-oncology-society-pros-lmic-and-pediatric-oncology-in-developing-countries-podc-working-groups-of-the-international
#4
Jeannette Parkes, Clayton Hess, Hester Burger, Yavuz Anacak, Verity Ahern, Scott C Howard, Moawia Elhassan, Soha Ahmed, Mithra Ghalibafian, Ahmed Nadeem Abbasi, Bilal Mazhar Qureshi, Mohamed Zaghloul, Eduardo Zubizarreta, Pierre Bey, Alan Davidson, Eric Bouffet, Natia Esiashvili
Pediatric radiotherapy is a critical part of pediatric oncology protocols and the quality of the radiotherapy may determine the future quality of life for long-term survivors. Multidisciplinary team decision making provides the basis for high-quality care. However, delivery of high-quality radiotherapy is dependent on resources. This article provides guidelines for delivery of good quality radiation therapy in resource-limited countries based on rational procurement and maintenance planning, protocol development, three-dimensional planning, quality assurance, and adequate staff numbers and training...
December 2017: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/29286563/etv6-ntrk3-in-congenital-mesoblastic-nephroma-a-report-of-the-siop-gpoh-nephroblastoma-study
#5
Christian Vokuhl, Nasenien Nourkami-Tutdibi, Rhoikos Furtwängler, Manfred Gessler, Norbert Graf, Ivo Leuschner
BACKGROUND: Congenital mesoblastic nephroma (MN) is a rare pediatric renal tumor representing approximately 5% of all pediatric renal tumors. Three different types of MN are distinguished histologically: classical, cellular, and mixed. A frequent genetic alteration is the translocation t(12;15) resulting in a fusion of the ETV6 gene on 12p13 and the NTRK3 gene on 15p15 that occurs almost exclusively in cellular MN. The aim of this study was to determine translocation status of a large cohort of MN with respect to tumor subtype and outcome...
December 29, 2017: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/29246796/current-state-of-renal-tumor-surgery-among-pediatric-surgeons-and-pediatric-urologists-a-survey-of-american-pediatric-surgical-association-apsa-and-society-for-pediatric-urology-spu-members
#6
Nicholas G Cost, Jennifer H Aldrink, Amanda F Saltzman, Roshni Dasgupta, Kenneth W Gow, Richard Glick, Peter F Ehrlich
INTRODUCTION: Anecdotally, renal tumor (RT) surgery makes up a limited portion of the practice for most pediatric urologists and pediatric surgeons. Data are lacking on the current perceptions of RT surgery, both volume of surgery and issues related to surgical practice, among pediatric surgeons (PS) and pediatric urologists (PU). OBJECTIVES: To describe practice patterns of pediatric renal tumor (RT) surgery and identify factors related to higher reported volumes of RT surgery...
December 2, 2017: Journal of Pediatric Urology
https://www.readbyqxmd.com/read/29211298/prognostic-relevance-of-early-radiologic-response-to-induction-chemotherapy-in-pediatric-rhabdomyosarcoma-a-report-from-the-international-society-of-pediatric-oncology-malignant-mesenchymal-tumor-95-study
#7
Bas Vaarwerk, Johanna H van der Lee, Willemijn B Breunis, Daniel Orbach, Julia C Chisholm, Nathalie Cozic, Meriel Jenney, Rick R van Rijn, Kieran McHugh, Soledad Gallego, Heidi Glosli, Christine Devalck, Mark N Gaze, Anna Kelsey, Christophe Bergeron, Michael C G Stevens, Odile Oberlin, Veronique Minard-Colin, Johannes H M Merks
BACKGROUND: Early response to induction chemotherapy is used in current European guidelines to evaluate the efficacy of chemotherapy and subsequently to adapt treatment in pediatric patients with rhabdomyosarcoma (RMS). However, existing literature on the prognostic value of early radiologic response on survival is contradictory; here the prognostic value is analyzed with data from the International Society of Pediatric Oncology (SIOP) Malignant Mesenchymal Tumor 95 (MMT-95) study. METHODS: This study examined 432 Intergroup Rhabdomyosarcoma Study Grouping III (macroscopic residue) patients enrolled in the SIOP MMT-95 study with a response assessment after 3 courses of chemotherapy (a 2-dimensional assessment)...
December 6, 2017: Cancer
https://www.readbyqxmd.com/read/29140495/traditional-and-complementary-medicine-in-pediatric-oncology-and-low-middle-income-countries-recommendations-from-the-international-society-of-pediatric-oncology-siop-t-cm-collaborative
#8
Elena J Ladas, Stacey Marjerrison, Brijesh Arora, Peter B Hesseling, Roberta Ortiz, Federico Antillon, Shalini Jatia, Glenn M Afungchwi
Significant strides have been made in the treatment of childhood cancer. Improvements in survival have led to increased attention toward supportive care indications; including the use of traditional and complementary medicine (T&CM). The use of T&CM among children and adolescents with cancer is well documented in both high-income countries (HICs) and low-middle income countries (LMICs). A higher incidence of the use of T&CM has been reported among children undergoing treatment in LMICs, which has elevated concerns related to drug interactions, adherence to therapy, and treatment-related toxicities...
November 1, 2017: Journal of the National Cancer Institute. Monographs
https://www.readbyqxmd.com/read/29128947/t2-based-mr-imaging-gradient-echo-or-susceptibility-weighted-imaging-in-midline-and-off-midline-intracranial-germ-cell-tumors-a-pilot-study
#9
Giovanni Morana, Cesar Augusto Alves, Domenico Tortora, Jonathan L Finlay, Mariasavina Severino, Paolo Nozza, Marcello Ravegnani, Marco Pavanello, Claudia Milanaccio, Mohamad Maghnie, Andrea Rossi, Maria Luisa Garrè
PURPOSE: The role of T2*-based MR imaging in intracranial germ cell tumors (GCTs) has not been fully elucidated. The aim of this study was to evaluate the susceptibility-weighted imaging (SWI) or T2* gradient echo (GRE) features of germinomas and non-germinomatous germ cell tumors (NGGCTs) in midline and off-midline locations. METHODS: We retrospectively evaluated all consecutive pediatric patients referred to our institution between 2005 and 2016, for newly diagnosed, treatment-naïve intracranial GCT, who underwent MRI, including T2*-based MR imaging (T2* GRE sequences or SWI)...
November 11, 2017: Neuroradiology
https://www.readbyqxmd.com/read/29089605/position-paper-rationale-for-the-treatment-of-wilms-tumour-in-the-umbrella-siop-rtsg-2016-protocol
#10
REVIEW
Marry M van den Heuvel-Eibrink, Janna A Hol, Kathy Pritchard-Jones, Harm van Tinteren, Rhoikos Furtwängler, Arnauld C Verschuur, Gordan M Vujanic, Ivo Leuschner, Jesper Brok, Christian Rübe, Anne M Smets, Geert O Janssens, Jan Godzinski, Gema L Ramírez-Villar, Beatriz de Camargo, Heidi Segers, Paola Collini, Manfred Gessler, Christophe Bergeron, Filippo Spreafico, Norbert Graf
The Renal Tumour Study Group of the International Society of Paediatric Oncology (SIOP-RTSG) has developed a new protocol for the diagnosis and treatment of childhood renal tumours, the UMBRELLA SIOP-RTSG 2016 (the UMBRELLA protocol), to continue international collaboration in the treatment of childhood renal tumours. This protocol will support integrated biomarker and imaging research, focussing on assessing the independent prognostic value of genomic changes within the tumour and the volume of the blastemal component that survives preoperative chemotherapy...
December 2017: Nature Reviews. Urology
https://www.readbyqxmd.com/read/29077255/irinotecan-for-relapsed-wilms-tumor-in-pediatric-patients-siop-experience-and-review-of-the-literature-a-report-from-the-siop-renal-tumor-study-group
#11
Janna A Hol, Marry M van den Heuvel-Eibrink, Norbert Graf, Kathy Pritchard-Jones, Jesper Brok, Harm van Tinteren, Lisa Howell, Arnauld Verschuur, Christophe Bergeron, Leo Kager, Serena Catania, Filippo Spreafico, Annelies M C Mavinkurve-Groothuis
While irinotecan has been studied in various pediatric solid tumors, its potential role in Wilms tumor (WT) is less clear. We evaluated response and outcome of irinotecan-containing regimens in relapsed WT and compared our results to the available literature. Among 14 evaluable patients, one complete response (CR) and two partial responses (PRs) were observed in patients with initial intermediate-risk (CR and PR) and blastemal-type histologies (PR). Two patients were alive at last follow-up showing no evidence of disease...
October 27, 2017: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/29071540/current-and-emerging-treatment-strategies-for-children-with-progressive-chiasmatic-hypothalamic-glioma-diagnosed-as-infants-a-web-based-survey
#12
Amedeo A Azizi, Antoinette Y N Schouten-van Meeteren
Treatment of infant hypothalamic chiasmatic glioma (iCHG) is challenging, about 30% of the children progress during chemotherapy. Despite subsequent treatments the 5 year overall-survival rate is only 70%. This study investigates treatment strategies currently applied for progressive iCHG. A web-based questionnaire was sent out to the members of the SIOPE Brain Tumour Group asking for current second and third line strategies at progression during and after the end of first line therapy. The questionnaire was answered by 47 paediatric oncologists from 15 countries...
October 25, 2017: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/29066008/49th-siop-congress
#13
Allison Landman
No abstract text is available yet for this article.
October 20, 2017: Lancet Oncology
https://www.readbyqxmd.com/read/29048505/outcome-of-patients-with-intracranial-non-germinomatous-germ-cell-tumors-lessons-from-the-siop-cns-gct-96-trial
#14
Gabriele Calaminus, Didier Frappaz, Rolf Dieter Kortmann, Barbara Krefeld, Frank Saran, Torsten Pietsch, Alexandre Vasiljevic, Maria Luisa Garre, Umberto Ricardi, Jillian R Mann, Ulrich Göbel, Claire Alapetite, Matthew J Murray, James C Nicholson
Background: Following promising results to increase survival and reduce treatment burden in intracranial non-germinomatous germ cell tumors (NGGCTs), we conducted a European study using dose-intense chemotherapy followed by risk-adapted radiotherapy. Methods: All patients received 4 courses of cisplatin/etoposide/ifosfamide. Non-metastatic patients then received focal radiotherapy only (54 Gy); metastatic patients received 30 Gy craniospinal radiotherapy with 24 Gy boost to primary tumor and macroscopic metastatic sites...
July 5, 2017: Neuro-oncology
https://www.readbyqxmd.com/read/29018578/the-care-of-adolescents-and-young-adults-with-cancer-results-of-the-esmo-siope-survey
#15
Emmanouil Saloustros, Daniel P Stark, Kyriaki Michailidou, Giannis Mountzios, Laurence Brugieres, Fedro Alessandro Peccatori, Svetlana Jezdic, Samira Essiaf, Jean-Yves Douillard, Stefan Bielack
INTRODUCTION: Adolescents and young adults (AYA) with cancer require dedicated clinical management and care. Little is known about the training and practice of European healthcare providers in regard to AYA and the availability of specialised services. METHODS: A link to an online survey was sent to members of the European Society for Medical Oncology (ESMO) and the European Society for Paediatric Oncology (SIOPE). The link was also sent to ESMO National Representatives and circulated to other European oncology groups...
2017: ESMO Open
https://www.readbyqxmd.com/read/29016183/paul-w-thayer-1927-2017
#16
Michael A Campion
Presents an obituary for Paul W. Thayer, who died on January 25, 2017, at the age of 89. Thayer was an industrial and organizational psychologist probably most distinguished by his professional service. He was a fellow of the American Psychological Association (APA), American Psychological Society (APS), and Society for Industrial and Organizational Psychology (SIOP). He received multiple awards for his service, including SIOP's Distinguished Professional Contributions Award (1986) and its Distinguished Service Award (1990), as well as the APA Award for Distinguished Service to Psychological Science (2014)...
October 2017: American Psychologist
https://www.readbyqxmd.com/read/28863244/abstracts-from-the-49th-congress-of-the-international-society-of-paediatric-oncology-siop-washington-dc-usa-october-12-15-2017
#17
(no author information available yet)
No abstract text is available yet for this article.
November 2017: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/28843054/high-dose-treatment-for-malignant-rhabdoid-tumor-of-the-kidney-no-evidence-for-improved-survival-the-gesellschaft-f%C3%A3-r-p%C3%A3-diatrische-onkologie-und-h%C3%A3-matologie-gpoh-experience
#18
Rhoikos Furtwängler, Leo Kager, Patrick Melchior, Christian Rübe, Martin Ebinger, Nasenien Nourkami-Tutdibi, Felix Niggli, Steven Warmann, Jochen Hubertus, Gabriele Amman, Ivo Leuschner, Christian Vokuhl, Norbert Graf, Michael C Frühwald
BACKGROUND: Malignant rhabdoid tumor of the kidney (MRTK) is the most aggressive childhood renal tumor with overall survival (OS) rates ranging from 22% to 42%. Whether high-dose chemotherapy with autologous stem-cell transplantation (HDSCT) in an intensive first-line treatment offers additional benefit is an ongoing discussion. METHODS: A retrospective analysis of all 58 patients with MRTK from Austria, Switzerland, and Germany treated in the framework of consecutive, prospective renal/rhabdoid tumor studies SIOP9/GPO, SIOP93-01/GPOH (where SIOP is International Society of Pediatric Oncology and GPOH is German Society of Pediatric Oncology and Hematology), SIOP2001/GPOH, and European Rhabdoid Tumor Registry from 1991 to 2014...
August 26, 2017: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/28830607/partnership-of-the-sociedade-brasileira-de-oncologia-pedi%C3%A3-trica-and-international-society-of-pediatric-oncology-to-improve-nutritional-care-for-children-with-cancer-in-brazil
#19
Karina Viani, Vicente Odone Filho, Sima Ferman, Teresa Cristina Cardoso Fonseca, Vanessa da Cunha Oliveira, Priscila Dos Santos Maia Lemos, Ronald D Barr, Elena J Ladas
The authors present a proposal of a partnership between the Sociedade Brasileira de Oncologia Pediátrica (SOBOPE) and the International Society of Pediatric Oncology (SIOP) to promote the standardization and improvement of nutritional care of kids under cancer treatment in Brazil. The results of the first meeting in Brazil as well as plans for future meetings are described.
July 2017: Revista Brasileira de Hematologia e Hemoterapia
https://www.readbyqxmd.com/read/28649001/a-european-randomised-controlled-trial-of-the-addition-of-etoposide-to-standard-vincristine-and-carboplatin-induction-as-part-of-an-18-month-treatment-programme-for-childhood-%C3%A2-16%C3%A2-years-low-grade-glioma%C3%A2-a-final-report
#20
RANDOMIZED CONTROLLED TRIAL
Astrid K Gnekow, David A Walker, Daniela Kandels, Susan Picton, Giorgio Perilongo, Jacques Grill, Tore Stokland, Per Eric Sandstrom, Monika Warmuth-Metz, Torsten Pietsch, Felice Giangaspero, René Schmidt, Andreas Faldum, Denise Kilmartin, Angela De Paoli, Gian Luca De Salvo
BACKGROUND: The use of chemotherapy to manage newly diagnosed low grade glioma (LGG) was first introduced in the 1980s. One randomised trial has studied two- versus four-drug regimens with a duration of 12 months of treatment after resection. METHODS: Within the European comprehensive treatment strategy for childhood LGG, the International Society of Paediatric Oncology-Low Grade Glioma (SIOP LGG) Committee launched a randomised trial involving 118 institutions and 11 countries to investigate the addition of etoposide (100 mg/m(2), days 1, 2 & 3) to a four-course induction of vincristine (1...
August 2017: European Journal of Cancer
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