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https://www.readbyqxmd.com/read/28436736/are-you-okay-to-drive-commuting-behavior-and-blood-alcohol-concentrations-amongst-restaurant-diners
#1
B Scott-Parker, L Stokes, S Panaho, M Cawkwell, J Caldwell
Objective Drink driving is widely recognised as a major road safety problem. In Australia, health promotion messages encourage monitoring the number of standard drinks consumed prior to driving. The pilot research aimed to investigate commuting behaviour and blood alcohol concentration (BAC) of diners, including intended-drivers, at Sunshine Coast restaurants. Methods Five hundred and forty-four diners (n = 260 males) consented to participate in a brief interview and to use a breathalyser device to measure their BAC...
February 25, 2017: Traffic Injury Prevention
https://www.readbyqxmd.com/read/28431029/the-chinese-version-of-the-brief-assessment-of-cognition-in-schizophrenia-data-of-a-large-scale-mandarin-speaking-population
#2
Liang-Jen Wang, Yu-Chi Huang, Chi-Fa Hung, Chih-Ken Chen, Yi-Chih Chen, Pei-Yi Lee, Si-Ming Wang, Ming-Hsiung Liu, Chia-Ju Lin, Su-Ting Hsu
Objective: The Brief Assessment of Cognition in Schizophrenia (BACS) is a cognitive assessment tool used to measure the broad aspects of cognition that are most frequently impaired in patients with schizophrenia. This study aims to develop the normative data of the Chinese version of the BACS among the Mandarin-speaking population. Method: This cross-sectional study included 382 healthy participants (age range: 19-79 years; mean age: 48.0 ± 16.7 years, 47.6% men) in Taiwan, who were evaluated with the BACS...
May 1, 2017: Archives of Clinical Neuropsychology: the Official Journal of the National Academy of Neuropsychologists
https://www.readbyqxmd.com/read/28428650/routine-mammography-an-opportunity-for-the-diagnosis-of-chronic-degenerative-diseases-a-cross-sectional-study
#3
Flávio Augusto Teixeira Ronzani, Filomena Maria Kirchmaier, Nathália Mussi Monteze, Edson José de Carvalho Magacho, Marcus Gomes Bastos, Natália Maria da Silva Fernandes
OBJECTIVE: The aim of this study was to evaluate breast arterial calcification (BAC) detected on routine mammography, analyzing its association with chronic degenerative disease. MATERIALS AND METHODS: This was a cross-sectional study involving women treated at a specialized outpatient clinic for high-risk hypertension, diabetes, or chronic kidney disease, as well as volunteers who participated in a study to validate a method of screening for occult renal disease...
March 2017: Radiologia Brasileira
https://www.readbyqxmd.com/read/28425492/fluorescence-and-bioluminescence-imaging-of-angiogenesis-in-flk1-nano-lantern-transgenic-mice
#4
Jun Matsushita, Shigenori Inagaki, Tomomi Nishie, Tomoki Sakasai, Junko Tanaka, Chisato Watanabe, Ken-Ichi Mizutani, Yoshihiro Miwa, Ken Matsumoto, Kazuhiro Takara, Hisamichi Naito, Hiroyasu Kidoya, Nobuyuki Takakura, Takeharu Nagai, Satoru Takahashi, Masatsugu Ema
Angiogenesis is important for normal development as well as for tumour growth. However, the molecular and cellular mechanisms underlying angiogenesis are not fully understood, partly because of the lack of a good animal model for imaging. Here, we report the generation of a novel transgenic (Tg) mouse that expresses a bioluminescent reporter protein, Nano-lantern, under the control of Fetal liver kinase 1 (Flk1). Flk1-Nano-lantern BAC Tg mice recapitulated endogenous Flk1 expression in endothelial cells and lymphatic endothelial cells during development and tumour growth...
April 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28413167/impact-of-a-new-law-to-reduce-the-legal-blood-alcohol-concentration-limit-a-poisson-regression-analysis-and-descriptive-approach
#5
Beatriz Nistal-Nuño
BACKGROUND: In Chile, a new law introduced in March 2012 lowered the blood alcohol concentration (BAC) limit for impaired drivers from 0.1% to 0.08% and the BAC limit for driving under the influence of alcohol from 0.05% to 0.03%, but its effectiveness remains uncertain. The goal of this investigation was to evaluate the effects of this enactment on road traffic injuries and fatalities in Chile. STUDY DESIGN: A retrospective cohort study. METHODS: Data were analyzed using a descriptive and a Generalized Linear Models approach, type of Poisson regression, to analyze deaths and injuries in a series of additive Log-Linear Models accounting for the effects of law implementation, month influence, a linear time trend and population exposure...
March 31, 2017: Journal of Research in Health Sciences
https://www.readbyqxmd.com/read/28413047/a-homolog-of-teleostean-signal-transducer-and-activator-of-transcription-3-stat3-from-rock-bream-oplegnathus-fasciatus-structural-insights-transcriptional-modulation-and-subcellular-localization
#6
S D N K Bathige, William Shanthakumar Thulasitha, Navaneethaiyer Umasuthan, J D H E Jayasinghe, Qiang Wan, Bo-Hye Nam, Jehee Lee
Signal transducer and activator of transcription 3 (STAT3) is one of the crucial transcription factors in the Janus kinase (JAK)/STAT signaling pathway, and it was previously considered as acute phase response factor. A number of interleukins (ILs) such as IL-5, IL-6, IL-9, IL-10, IL-12, and IL-22 are known to be involved in activation of STAT3. In addition, various growth factors and pathogenic or oxidative stresses mediate the activation of a wide range of functions via STAT3. In this study, a STAT3 homolog was identified and functionally characterized from rock bream (RbSTAT3), Oplegnathus fasciatus...
April 2017: Veterinary Immunology and Immunopathology
https://www.readbyqxmd.com/read/28412303/laboratory-analysis-of-risky-driving-at-0-05-and-0-08-blood-alcohol-concentration
#7
Nicholas A Van Dyke, Mark T Fillmore
BACKGROUND: The public health costs associated with alcohol-related traffic crashes are a continuing problem for society. One harm reduction strategy has been to employ per se limits for blood alcohol concentrations (BACs) at which drivers can legally operate motor vehicles. This limit is currently 0.08% in all 50 US states. Recently, the National Transportation Safety Board proposed lowering the legal limit to 0.05% (NTSB, 2013). While research has well-validated the ability of alcohol to impair driving performance and heighten crash-risk at these BACs, relatively little is known about the degree to which alcohol might increase drivers' risk-taking...
March 31, 2017: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/28410498/smartstart-results-of-a-large-point-of-entry-study-into-preloading-alcohol-and-associated-behaviours
#8
Grant J Devilly, Corey Allen, Kathleen Brown
BACKGROUND: There is a growing trend of preloading with alcohol before entering entertainment districts. It is claimed that this occurs to save money and that preloading may be a good indicator of harmful drinking and risk taking behaviours more generally. No study has collected data from a large sample as the participants entered entertainment districts and measured blood alcohol concentration (BAC) levels and self-reported drinking and risk taking behaviours in a systematic way. METHODS: In this research, police and academics worked together to gauge the breadth and depth of preloading behaviours...
April 11, 2017: International Journal on Drug Policy
https://www.readbyqxmd.com/read/28407817/preliminary-study-of-the-ul55-gene-based-on-infectious-chinese-virulent-duck-enteritis-virus-bacterial-artificial-chromosome-clone
#9
Ying Wu, Yangguang Li, Mingshu Wang, Kunfeng Sun, Renyong Jia, Shun Chen, Dekang Zhu, Mafeng Liu, Qiao Yang, Xinxin Zhao, Xiaoyue Chen, Anchun Cheng
BACKGROUND: Lethal Duck Enteritis Virus (DEV) infection can cause high morbidity and mortality of many species of waterfowl within the order Anseriformes. However, little is known about the function of viral genes including the conserved UL55 gene among alpha herpes virus due to the obstacles in maintenance and manipulation of DEV genome in host cells. METHODS: In this paper, we constructed an infectious bacteria artificial chromosome (BAC) clone of the lethal clinical isolate duck enteritis virus Chinese virulent strain (DEV CHv) by inserting a transfer vector containing BAC mini-F sequence and selection marker EGFP into UL23 gene using homologous recombination...
April 13, 2017: Virology Journal
https://www.readbyqxmd.com/read/28406692/effect-of-pre-and-post-weaning-high-fat-dietary-manipulation-on-intestinal-microflora-and-alkaline-phosphatase-activity-in-male-rats
#10
Z Šefčíková, D Bujňáková
We investigated the impact of a high-fat (HF) diet during pre- and post-weaning periods on the intestinal microbiota and alkaline phosphatase (AP) activity in male rats. Nutrition from birth was influenced by feeding rat dams with either a standard or HF diet. After weaning male pups nursed by control dams continued on a standard diet (CC) or HF diet (C->HF), while offspring nursed by HF dams continued on HF diet (HF) or standard diet (HF->C). The numbers of Bacteriodes/Prevotella (BAC) and Lactobacillus/Enterococcus (LAB) in the gut were determined by FISH technique...
April 12, 2017: Physiological Research
https://www.readbyqxmd.com/read/28405024/antisense-oligonucleotide-therapy-for-spinocerebellar-ataxia-type-2
#11
Daniel R Scoles, Pratap Meera, Matthew D Schneider, Sharan Paul, Warunee Dansithong, Karla P Figueroa, Gene Hung, Frank Rigo, C Frank Bennett, Thomas S Otis, Stefan M Pulst
There are no disease-modifying treatments for adult human neurodegenerative diseases. Here we test RNA-targeted therapies in two mouse models of spinocerebellar ataxia type 2 (SCA2), an autosomal dominant polyglutamine disease. Both models recreate the progressive adult-onset dysfunction and degeneration of a neuronal network that are seen in patients, including decreased firing frequency of cerebellar Purkinje cells and a decline in motor function. We developed a potential therapy directed at the ATXN2 gene by screening 152 antisense oligonucleotides (ASOs)...
April 20, 2017: Nature
https://www.readbyqxmd.com/read/28397229/-prenatal-diagnosis-of-a-rare-case-of-7q11-23-duplication-syndrome
#12
Guangjuan Ma, Yulin Jiang, Zhen Yu, Wencheng Dai, Ning Liu, Huijun Li, Gulinazi Mijiti
OBJECTIVE: To explore the application of combined techniques for the prenatal diagnosis of a case with 7q11.23 duplication. METHODS: Amniocentesis was performed in the second trimester for a mother with a high risk suggested by serological prenatal screening. G-banded chromosomal analysis was performed on cultured amniocytes and peripheral blood samples from both parents. DNA from amniotic fluid sample was isolated for a BACs-on-Beads (BoBs) assay. To define the range of duplication, copy number variation was determined with single nucleotide polymorphism array (SNP array, Affymetrix CytoScan 750K) and fluorescence in situ hybridization (FISH) analysis...
April 10, 2017: Zhonghua Yi Xue Yi Chuan Xue za Zhi, Zhonghua Yixue Yichuanxue Zazhi, Chinese Journal of Medical Genetics
https://www.readbyqxmd.com/read/28397216/-prenatal-diagnosis-of-22q11-microdeletion-syndrome
#13
Meiying Cai, Hailong Huang, Na Lin, Nan Guo, Xiaoqing Wu, Linjuan Su, Liangpu Xu
OBJECTIVE: To establish a method for the prenatal diagnosis of 22q11 microdeletion syndrome. METHODS: BACs-on-Beads (BoBs) and fluorescence in situ hybridization (FISH) were performed on a fetus for whom amniotic chromosomal culturing has failed and a pair of twin fetuses suspected for 22q11 deletion syndrome. RESULTS: 22q11 microdeletion was detected in all 3 fetuses by prenatal BoBs as well as FISH, with only one red signal detected at the DiGeorge/VCFS N25 site and two green signals on the 22q13...
April 10, 2017: Zhonghua Yi Xue Yi Chuan Xue za Zhi, Zhonghua Yixue Yichuanxue Zazhi, Chinese Journal of Medical Genetics
https://www.readbyqxmd.com/read/28390849/cognitive-burden-of-anticholinergic-medications-in-psychotic-disorders
#14
Seenae Eum, S Kristian Hill, Leah H Rubin, Ryan M Carnahan, James L Reilly, Elena I Ivleva, Sarah K Keedy, Carol A Tamminga, Godfrey D Pearlson, Brett A Clementz, Elliot S Gershon, Matcheri S Keshavan, Richard S E Keefe, John A Sweeney, Jeffrey R Bishop
BACKGROUND: Patients with psychotic disorders are often treated with numerous medications, many of which have anticholinergic activity. We assessed cognition in relation to the cumulative anticholinergic burden of multiple drugs included in treatment regimens of participants from the Bipolar-Schizophrenia Network on Intermediate Phenotypes (B-SNIP) study. METHOD: Clinically stable participants with schizophrenia (n=206), schizoaffective disorder (n=131), and psychotic bipolar disorder (n=146) were examined...
April 5, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/28386784/genetic-analysis-of-a-novel-reassortant-h11n9-isolated-from-waterfowl-in-south-korea-in-2016
#15
Tran Bac Le, In Hong Lee, Hyun Soo Kim, Seung Kyoo Oh, Sang Heui Seo
Aquatic birds are known to harbor all the known influenza A viruses. In the winter of January 2016, we surveyed influenza A virus in the feces of migratory birds in South Korea. The novel re-assorted H11N9 avian influenza virus, which contains genes from avian influenza viruses of poultry and wild birds, was isolated. The polymerase basic 2 (PB2), polymerase basic 1 (PB1), hemagglutinin (HA), and nucleoprotein (NP) genes were most closely related to those of domestic duck-origin avian influenza viruses, while the non-structural (NS) gene was closely related to that of domestic goose-origin avian influenza virus...
April 6, 2017: Virus Genes
https://www.readbyqxmd.com/read/28385489/developmental-neurotoxicity-of-different-pesticides-in-pc-12-cells-in-vitro
#16
Verena Christen, Manuel Rusconi, Pierre Crettaz, Karl Fent
The detection of developmental neurotoxicity (DNT) of chemicals has high relevance for protection of human health. However, DNT of many pesticides is only little known. Furthermore, validated in vitro systems for assessment of DNT are not well established. Here we employed the rat phaeochromocytoma cell line PC-12 to evaluate DNT of 18 frequently used pesticides of different classes, including neonicotinoids, pyrethroids, organophosphates, organochlorines, as well as quaternary ammonium compounds, the organic compound used in pesticides, piperonyl butoxide, as well as the insect repellent diethyltoluamide (DEET)...
April 3, 2017: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/28385226/stimulative-nanogels-with-enhanced-thermosensitivity-for-therapeutic-delivery-via-%C3%AE-cyclodextrin-induced-formation-of-inclusion-complexes
#17
Panpan Yi, Yifeng Wang, Shihao Zhang, Yuan Zhan, Yuhong Zhang, Zhengguang Sun, Yulin Li, Peixin He
To explore the potential biomedical application of thermoresponsive nanosystems, it is important to enhance their thermosensitivity to improve the controllability in delivery of therapeutic agents. The present work develops multifunctional nanogels with enhanced thermosensitivity through copolymerization of N-isopropylacrylamide (NIPAM) and acrylic acid (AA) in the presence of β-cyclodextrin (β-CD), using N,N'-bis(acryloyl)cystamine (BAC) as a biodegradable crosslinker. The resulting nanogels display significantly improved sensitivity in deswelling (swelling) behavior upon temperature increase (decrease) around body temperature...
June 15, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28385002/generation-characterization-and-application-in-serodiagnosis-of-recombinant-swine-vesicular-disease-viral-like-particles
#18
Wanhong Xu, Melissa Goolia, Tim Salo, Zhidong Zhang, Ming Yang
Swine vesicular disease virus (SVDV) is a highly contagious disease that causes vesicular disease in pigs. The importance of the disease is due to its indistinguishable clinical signs from foot-and-mouth disease that prevents international trade of swine and related products. SVD-specific antibody detection using the enzyme-linked immunosorbent assay (ELISA) is the most versatile and commonly used method for SVD surveillance and export certification. The inactivated SVD virus is the commonly used antigen in ELISAs...
April 6, 2017: Journal of Veterinary Science
https://www.readbyqxmd.com/read/28379456/patterns-of-polymorphism-at-the-self-incompatibility-locus-in-1-083-arabidopsis-thaliana-genomes
#19
Takashi Tsuchimatsu, Pauline M Goubet, Sophie Gallina, Anne-Catherine Holl, Isabelle Fobis-Loisy, Hélène Bergès, William Marande, Elisa Prat, Dazhe Meng, Quan Long, Alexander Platzer, Magnus Nordborg, Xavier Vekemans, Vincent Castric
Although the transition to selfing in the model plant Arabidopsis thaliana involved the loss of the self-incompatibility (SI) system, it clearly did not occur due to the fixation of a single inactivating mutation at the locus determining the specificities of SI (the S-locus). At least three groups of divergent haplotypes (haplogroups), corresponding to ancient functional S-alleles, have been maintained at this locus, and extensive functional studies have shown that all three carry distinct inactivating mutations...
April 4, 2017: Molecular Biology and Evolution
https://www.readbyqxmd.com/read/28377880/paradoxical-bronchospasm-from-benzalkonium-chloride-bac-preservative-in-albuterol-nebulizer-solution-in-a-patient-with-acute-severe-asthma-a-case-report-and-literature-review-of-airway-effects-of-bac
#20
Mathew George, Saumya Vinod Joshi, Emily Concepcion, Haesoon Lee
Nebulized bronchodilator solutions are available in the United States as both nonsterile and sterile-filled products. Sulfites, benzalkonium chloride (BAC), or chlorobutanol are added to nonsterile products to prevent bacterial growth. Bronchoconstriction from inhaled BAC is cumulative, prolonged, and correlates directly with basal airway responsiveness. The multi-dose dropper bottle of albuterol sulfate solution contains 50 μg BAC per/2.5 mg of albuterol, which may be below or at the lower limit of the threshold dose for bronchoconstriction...
2017: Respiratory Medicine Case Reports
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