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https://www.readbyqxmd.com/read/28230897/unnatural-and-violent-death-in-cases-with-high-blood-alcohol-concentration-autopsy-study
#1
Danica Cvetković, Vladimir Živković, Vera Lukić, Slobodan Nikolić
The use of alcohol increases the risk of dying from unnatural or violent causes. The presented study explored the distribution of age, gender, cause, and circumstances of death in persons who died in an unnatural and violent manner, with a blood alcohol concentration (BAC) higher than 0.3 g/dL, and where the cause of death was not alcohol intoxication. We defined the control (0 < BAC < 0.3 g/dL) and study (BAC ≥ 0.3 g/dL) groups, as in subjects with these concentrations, there is a significant risk of gross intoxication, stupor, and death...
February 23, 2017: Journal of Forensic Sciences
https://www.readbyqxmd.com/read/28229234/sequencing-the-genomic-regions-flanking-s-linked-pvglo-sequences-confirms-the-presence-of-two-glo-loci-one-of-which-lies-adjacent-to-the-style-length-determinant-gene-cyp734a50
#2
Benjamin A Burrows, Andrew G McCubbin
Primula vulgaris contains two GLOBOSA loci, one located adjacent to the style length determinant gene CYP734A50 which lies within the S -locus. Using a combination of BAC walking and PacBio sequencing, we have sequenced two substantial genomic contigs in and around the S-locus of Primula vulgaris. Using these data, we were able to demonstrate that two alleles of PvGlo (P) as well as PvGlo (T) can be present in the genome of a single plant, providing empirical evidence that these two forms of the MADS-box gene GLOBOSA are separate loci and not allelic as previously reported...
February 22, 2017: Plant Reproduction
https://www.readbyqxmd.com/read/28222695/evolution-and-expression-of-the-fructokinase-gene-family-in-saccharum
#3
Yihong Chen, Qing Zhang, Weichang Hu, Xingtan Zhang, Liming Wang, Xiuting Hua, Qingyi Yu, Ray Ming, Jisen Zhang
BACKGROUND: Sugarcane is an important sugar crop contributing up to about 80% of the world sugar production. Efforts to characterize the genes involved in sugar metabolism at the molecular level are growing since increasing sugar content is a major goal in the breeding of new sugarcane varieties. Fructokinases (FRK) are the main fructose phosphorylating enzymes with high substrate specificity and affinity. RESULTS: In this study, by combining comparative genomics approaches with BAC resources, seven fructokinase genes were identified in S...
February 21, 2017: BMC Genomics
https://www.readbyqxmd.com/read/28216252/calcification-of-the-splenic-iliac-and-breast-arteries-and-risk-of-all-cause-and-cardiovascular-mortality
#4
Eva J E Hendriks, Joline W J Beulens, Pim A de Jong, Yvonne T van der Schouw, Wei-Ning Sun, C Michael Wright, Michael H Criqui, Matthew A Allison, Joachim H Ix
BACKGROUND AND AIMS: CVD risks associated with coronary artery calcification (CAC) and aortic calcification (AC) are well known, but less is known about other calcified arteries. We aimed to assess the associations of arterial calcification in the breast, splenic, and internal and external iliac arteries with CVD risk factors and mortality. METHODS: We conducted a case-cohort study nested in a cohort of 5196 individuals who self-referred or were referred by a health care provider for whole body computed tomography (CT), including a random subcohort (n = 395) and total and CVD mortality cases (n = 298 and n = 90), who died during a median follow-up of 9...
January 30, 2017: Atherosclerosis
https://www.readbyqxmd.com/read/28213337/effect-of-advanced-oxidation-on-n-nitrosodimethylamine-ndma-formation-and-microbial-ecology-during-pilot-scale-biological-activated-carbon-filtration
#5
Dong Li, Ben Stanford, Eric Dickenson, Wendell O Khunjar, Carissa L Homme, Erik J Rosenfeldt, Jonathan O Sharp
Water treatment combining advanced oxidative processes with subsequent exposure to biological activated carbon (BAC) holds promise for the attenuation of recalcitrant pollutants. Here we contrast oxidation and subsequent biofiltration of treated wastewater effluent employing either ozone or UV/H2O2 followed by BAC during pilot-scale implementation. Both treatment trains largely met target water quality goals by facilitating the removal of a suite of trace organics and bulk water parameters. N-nitrosodimethylamine (NDMA) formation was observed in ozone fed BAC columns during biofiltration and to a lesser extent in UV/H2O2 fed columns and was most pronounced at 20 min of empty bed contact time (EBCT) when compared to shorter EBCTs evaluated...
February 2, 2017: Water Research
https://www.readbyqxmd.com/read/28213137/foxo1-is-a-downstream-effector-of-isl1-in-direct-pathway-striatal-projection-neuron-development-within-the-embryonic-mouse-telencephalon
#6
R R Waclaw, L A Ehrman, P Merchan-Sala, V Kohli, D Nardini, K Campbell
Recent studies have shown that the LIM-homeodomain transcription factor Isl1 is required for the survival and differentiation of direct pathway striatonigral neurons during embryonic development. The downstream effectors of Isl1 in these processes are presently unknown. We show here that Foxo1, a transcription factor that has been implicated in cell survival, is expressed in striatal projection neurons (SPNs) that derive from the Isl1 lineage (i.e. direct pathway SPNs). Moreover, Isl1 conditional knockouts (cKOs) show a severe loss of Foxo1 expression at E15...
February 14, 2017: Molecular and Cellular Neurosciences
https://www.readbyqxmd.com/read/28208716/cell-imaging-counting-as-a-novel-ex-vivo-approach-for-investigating-drug-induced-hepatotoxicity-in-zebrafish-larvae
#7
Xuan-Bac Nguyen, Stanislav Kislyuk, Duc-Hung Pham, Angela Kecskés, Jan Maes, Deirdre Cabooter, Pieter Annaert, Peter De Witte, Annelii Ny
Drug-induced liver injury (DILI) is the most common reason for failures during the drug development process and for safety-related withdrawal of drugs from the pharmaceutical market. Therefore, having tools and techniques that can detect hepatotoxic properties in drug candidates at an early discovery stage is highly desirable. In this study, cell imaging counting was used to measure in a fast, straightforward, and unbiased way the effect of paracetamol and tetracycline, (compounds known to cause hepatotoxicity in humans) on the amount of DsRed-labeled hepatocytes recovered by protease digestion from Tg(fabp10a:DsRed) transgenic zebrafish...
February 8, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28205609/association-of-fronto-temporal-function-with-cognitive-ability-in-schizophrenia
#8
Shenghong Pu, Kazuyuki Nakagome, Masashi Itakura, Masaaki Iwata, Izumi Nagata, Koichi Kaneko
Deficits in neuropsychological performance are common in schizophrenia, but their relationship with the fronto-temporal functional abnormalities associated with this condition remains unclear. We explored the relationship between neuropsychological performance as measured using the Brief Assessment of Cognition in Schizophrenia (BACS) and the Social Cognition Screening Questionnaire theory of mind (ToM) subscale and fronto-temporal function in 23 patients with schizophrenia and 23 age- and gender-matched healthy controls (HCs), using 52-channel near-infrared spectroscopy (NIRS)...
February 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28203238/differential-ability-of-bovine-antimicrobial-cathelicidins-to-mediate-nucleic-acid-sensing-by-epithelial-cells
#9
Arnaud Baumann, Mirjam Susanna Kiener, Brendan Haigh, Vincent Perreten, Artur Summerfield
Cathelicidins encompass a family of cationic peptides characterized by antimicrobial activity and other functions, such as the ability to enhance the sensing of nucleic acids by the innate immune system. The present study aimed to investigate the ability of the bovine cathelicidins indolicidin, bactenecin (Bac)1, Bac5, bovine myeloid antimicrobial peptide (BMAP)-27, BMAP-28, and BMAP-34 to inhibit the growth of bacteria and to enhance the sensing of nucleic acid by the host's immune system. BMAP-27 was the most effective at killing Staphylococcus aureus, Streptococcus uberis, and Escherichia coli, and this was dependent on its amphipathic structure and cationic charge...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28201990/a-vast-genomic-deletion-in-the-c56bl-6-genome-affects-different-genes-within-the-ifi200-cluster-on-chromosome-1-and-mediates-obesity-and-insulin-resistance
#10
Heike Vogel, Markus Jähnert, Mandy Stadion, Daniela Matzke, Stephan Scherneck, Annette Schürmann
BACKGROUND: Obesity, the excessive accumulation of body fat, is a highly heritable and genetically heterogeneous disorder. The complex, polygenic basis for the disease consisting of a network of different gene variants is still not completely known. RESULTS: In the current study we generated a BAC library of the obese-prone NZO strain to clarify the genomic alteration within the gene cluster Ifi200 on chr.1 including Ifi202b, an obesity gene that is in contrast to NZO not expressed in the lean B6 mouse...
February 15, 2017: BMC Genomics
https://www.readbyqxmd.com/read/28185941/expression-map-of-a-complete-set-of-gustatory-receptor-genes-in-chemosensory-organs-of-bombyx-mori
#11
Huizhen Guo, Tingcai Cheng, Zhiwei Chen, Liang Jiang, Youbing Guo, Jianqiu Liu, Shenglong Li, Kiyoko Taniai, Kiyoshi Asaoka, Keiko Kadono-Okuda, Kallare P Arunkumar, Jiaqi Wu, Hirohisa Kishino, Huijie Zhang, Rakesh K Seth, Karumathil P Gopinathan, Nicolas Montagné, Emmanuelle Jacquin-Joly, Marian R Goldsmith, Qingyou Xia, Kazuei Mita
Most lepidopteran species are herbivores, and interaction with host plants affects their gene expression and behavior as well as their genome evolution. Gustatory receptors (Grs) are expected to mediate host plant selection, feeding, oviposition and courtship behavior. However, due to their high diversity, sequence divergence and extremely low level of expression it has been difficult to identify precisely a complete set of Grs in Lepidoptera. By manual annotation and BAC sequencing, we improved annotation of 43 gene sequences compared with previously reported Grs in the most studied lepidopteran model, the silkworm, Bombyx mori, and identified 7 new tandem copies of BmGr30 on chromosome 7, bringing the total number of BmGrs to 76...
February 6, 2017: Insect Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/28182471/efficacy-of-cognitive-rehabilitation-using-computer-software-with-individuals-living-with-schizophrenia-a-randomized-controlled-trial-in-japan
#12
Kazuhiko Iwata, Yasuhiro Matsuda, Sayaka Sato, Shunichi Furukawa, Yukako Watanabe, Norifumi Hatsuse, Emi Ikebuchi
OBJECTIVE: Cognitive impairment is common in schizophrenia, and is associated with poor psychosocial functioning. Previous studies had inconsistently shown improvement in cognitive functions with cognitive remediation therapy. This study examined whether cognitive remediation is effective in improving both cognitive and social functions in schizophrenia in outpatient settings that provide learning-based psychiatric rehabilitation. This study is the first randomized controlled trial of cognitive remediation in Japan...
February 9, 2017: Psychiatric Rehabilitation Journal
https://www.readbyqxmd.com/read/28177843/estimation-of-long-terminal-repeat-element-content-in-the-i-helicoverpa-zea-i-genome-from-high-throughput-sequencing-of-bacterial-artificial-chromosome-bac-pools
#13
Brad Coates, Craig A Abel, Omaththage P Perera
The lepidopteran pest insect <i>Helicoverpa zea</i> feeds on cultivated corn and cotton across the Americas where control remains challenging due to evolution of resistance to chemical and transgenic insecticidal toxins, yet genomic resources remain scarce for this species. A bacterial artificial chromosome (BAC) library having a mean genomic insert size of 145±20 kb was created from a laboratory strain of <i>H. zea</i>, which provides ~12.9-fold coverage of a 362.8±8.8 Mb (0.37±0...
November 15, 2016: Genome Génome / Conseil National de Recherches Canada
https://www.readbyqxmd.com/read/28177835/analysis-of-the-histone-cluster-in-senegalese-sole-solea-senegalensis-evidence-for-a-divergent-evolution-of-two-canonical-histone-clusters
#14
Manuel Alejandro Merlo, Roger Iziga, Silvia Portela, Ismael Cross, Nadezda Kosyakova, Thomas Liehr, Manuel Manchado, Laureana Rebordinos
The Senegalese sole (Solea senegalensis) is commercially very important, and is a priority species for aquaculture product diversification. The main histone cluster was found in two BAC clones. However, two replacement histones (H1.0 and H3.3) were found in another BAC clone. Different types of canonical H2A and H2B have been found in one species for the first time. Phylogenetic analysis demonstrated that the different H1, H2A and H2B types were all more similar to each other than to canonical histones from other species...
December 10, 2016: Genome Génome / Conseil National de Recherches Canada
https://www.readbyqxmd.com/read/28169563/collinearity-between-potato-solanum-tuberosum-l-and-wild-relatives-assessed-by-comparative-cytogenetic-mapping
#15
Paola Gaiero, José van de Belt, Francisco Vilaró, M Eric Schranz, Pablo Speranza, Hans de Jong
A major bottleneck to introgressive hybridization is the lack of genome collinearity between the donor (alien) genome and the recipient crop genome. Structural differences between the homeologs may create unbalanced segregation of chromosomes or cause linkage drag. To assess large-scale collinearity between potato and two of its wild relatives (Solanum commersonii and Solanum chacoense), we used BAC-FISH mapping of sequences with known positions on the RH potato map. BAC probes could successfully be hybridized to the S...
November 14, 2016: Genome Génome / Conseil National de Recherches Canada
https://www.readbyqxmd.com/read/28167702/assessment-of-altered-lipid-homeostasis-by-hilic-ion-mobility-mass-spectrometry-based-lipidomics
#16
Kelly M Hines, Josi Herron, Libin Xu
Ion mobility-mass spectrometry (IM-MS) has proven to be a highly informative technique for the characterization of lipids from cells and tissues. We report the combination of hydrophilic interaction liquid chromatography (HILIC) with traveling wave IM-MS (TWIM-MS) for comprehensive lipidomics analysis. Main lipid categories such as glycerolipids, sphingolipids, and glycerophospholipids are separated on the basis of their lipid backbones in the IM dimension while sub-classes of each category are mostly separated based on their headgroups in the HILIC dimension, demonstrating the orthogonality of HILIC and IM separations...
February 6, 2017: Journal of Lipid Research
https://www.readbyqxmd.com/read/28166658/sodium-perbarate-and-benzalkonium-chloride-induce-dna-damage-in-chang-conjunctival-epithelial-cells
#17
Huina Zhang, Han Wu, Jun Yang, Juan Ye
: Content and objective: To investigate and compare the toxic effects of benzalkonium chloride (BAC) and new type oxidative preservative sodium perborate (NaBO3) on DNA damage, reactive oxygen species (ROS), and cell survival in immortalized human Chang conjunctival cells. MATERIAL AND METHODS: Cells were exposed to BAC and NaBO3 in concentrations of 0.00001% to 0.001% for 30 min. Cell viability was measured by the MTT test. Alkaline comet assay was used to detect DNA damage...
February 6, 2017: Cutaneous and Ocular Toxicology
https://www.readbyqxmd.com/read/28158225/visualizing-the-enteric-nervous-system-using-genetically-engineered-double-reporter-mice-comparison-with-immunofluorescence
#18
Yanfen Jiang, Hui Dong, Lars Eckmann, Elaine M Hanson, Katherine C Ihn, Ravinder K Mittal
BACKGROUND AND AIMS: The enteric nervous system (ENS) plays a crucial role in the control of gastrointestinal motility, secretion and absorption functions. Immunohistochemistry has been widely used to visualize neurons of the ENS for more than two decades. Genetically engineered mice that report specific proteins can also be used to visualize neurons of the ENS. The goal of our study was to develop a mouse that expresses fluorescent neuronal nitric oxide synthase (nNOS) and choline acetyltransferase (ChAT), the two proteins expressed in 95% of the ENS neurons...
2017: PloS One
https://www.readbyqxmd.com/read/28157829/how-should-remote-clinical-monitoring-be-used-to-treat-alcohol-use-disorders-initial-findings-from-an-expert-round-table-discussion
#19
Alan Gordon, Adi Jaffe, A Thomas McLellan, Gary Richardson, Gregory Skipper, Michel Sucher, Carlos F Tirado, Harold C Urschel
Scientific evidence combined with new health insurance coverage now enable a chronic illness management approach to the treatment of alcohol use disorders (AUDs), including regular monitoring of blood alcohol content (BAC), as a useful indicator of disease control. Recent technical advances now permit many different types of remote, real-time monitoring of BAC. However, there is no body of research to empirically guide clinicians in how to maximize the clinical potential of remote BAC monitoring.As an initial step in guiding and supporting such research, the manufacturer of one remote BAC monitoring system sponsored a group of experienced clinicians and clinical researchers to discuss 8 issues that generally affect remote, clinical BAC monitoring of "adults in outpatient AUD treatment...
February 2, 2017: Journal of Addiction Medicine
https://www.readbyqxmd.com/read/28155619/quantification-of-specific-glycation-sites-in-human-serum-albumin-as-prospective-type-2-diabetes-mellitus-biomarkers
#20
Sandro Spiller, Andrej Frolov, Ralf Hoffmann
Type 2 diabetes mellitus (T2DM) is the most common lifestyle disease affecting all countries. Due to its asymptomatic onset, it is often diagnosed after irreversible vascular complications have been initiated. Therefore, specific markers characteristic for very early disease stages and suitable for early diagnostics are required. Glycation of plasma proteins, such as human serum albumin (HSA), has been often suggested as marker. However, the total glycation degree of HSA does not provide sufficient information about short-term fluctuations of blood glucose concentrations due to the large number of glycation sites...
February 2, 2017: Protein and Peptide Letters
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