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https://www.readbyqxmd.com/read/29333873/survey-regarding-the-05-blood-alcohol-concentration-limit-for-driving-in-the-united-states
#1
Dary D Fiorentino, Brian D Martin
STRUCTURED ABSTRACT Background: On May 14, 2013, the National Transportation Safety Board ("NTSB") proposed that states lower the blood alcohol concentration ("BAC") illegal limit from .08 g/dL to .05 g/dL (also referred to as the ".08 law" and "the .05 limit," respectively). In March of 2017, this recommendation was signed into law in the State of Utah. OBJECTIVE: The objective of this survey is to investigate perceptions regarding enforcement of the .05 g/dL BAC limit. METHOD: Opinions of law enforcement officers, prosecutors, and defense attorneys were obtained through a series of questionnaires and focus groups...
January 15, 2018: Traffic Injury Prevention
https://www.readbyqxmd.com/read/29330416/virtual-genome-walking-across-the-32%C3%A2-gb-ambystoma-mexicanum-genome-assembling-gene-models-and-intronic-sequence
#2
Teri Evans, Andrew D Johnson, Matthew Loose
Large repeat rich genomes present challenges for assembly using short read technologies. The 32 Gb axolotl genome is estimated to contain ~19 Gb of repetitive DNA making an assembly from short reads alone effectively impossible. Indeed, this model species has been sequenced to 20× coverage but the reads could not be conventionally assembled. Using an alternative strategy, we have assembled subsets of these reads into scaffolds describing over 19,000 gene models. We call this method Virtual Genome Walking as it locally assembles whole genome reads based on a reference transcriptome, identifying exons and iteratively extending them into surrounding genomic sequence...
January 12, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29323932/the-effects-of-breath-alcohol-concentration-on-postural-control
#3
Dary D Fiorentino
STRUCTURED ABSTRACT Background: Two of the three standardized field sobriety tests that US law enforcement uses at roadside checks have a postural equilibrium component to them. Those tests have been validated to detect impairment caused by blood alcohol concentrations (BACs) of .08 g/dL or above. Many medical and traffic safety associations support a lower limit, and one state, Utah, has passed a law to lower the limit to .05 g/dL. Many studies have examined the effects of alcohol on postural control (of which postural equilibrium is a component), with a consensus emerging that impairment is usually found at BACs greater than ...
January 11, 2018: Traffic Injury Prevention
https://www.readbyqxmd.com/read/29317468/radiation-exposure-and-procedure-and-fluoroscopy-times-in-endovascular-treatment-of-intracranial-aneurysms-a-methodological-comparison
#4
Nicholas K Cheung, Michelle Boutchard, Michael W Carr, Jens J Froelich
BACKGROUND: Limited data are available for radiation exposure, and procedure and fluoroscopy times in neuroendovascular treatment (NET) strategies. OBJECTIVE: This study establishes and compares related parameters between coil embolization (COIL), balloon assisted coil embolization (BAC), stent assisted coil embolization (SAC), and flow diverting technology (FDT) in NET of intracranial aneurysms. MATERIALS AND METHODS: Between 2010 and 2017, 249 consecutive intracranial aneurysms underwent NET at a single center, all performed by the same operator...
January 9, 2018: Journal of Neurointerventional Surgery
https://www.readbyqxmd.com/read/29317205/pde6brd1-mutation-modifies-cataractogenesis-in-foxe3rct-mice
#5
Kenta Wada, Junichi Saito, Midori Yamaguchi, Yuta Seki, Masamune Furugori, Gou Takahashi, Yasumasa Nishito, Hiroshi Matsuda, Hiroshi Shitara, Yoshiaki Kikkawa
The Foxe3rct mutation, which causes early-onset cataracts, is a recessive mutation found in SJL/J mice. A previous study reported that cataract phenotypes are modified by the genetic background of mouse inbred strains and that the Pde6brd1 mutation, which induced degeneration of the photoreceptor cells, is a strong candidate genetic modifier to accelerate the severity of cataractogenesis of Foxe3rct mice. We created congenic mice by transferring a genomic region including the Foxe3rct mutation to the B6 genetic background, which does not carry the Pde6brd1 mutation...
January 6, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29313763/sexual-violence-and-the-risk-of-hiv-transmission-in-sexual-partners-of-male-injecting-drug-users-in-tien-du-district-bac-ninh-province-of-vietnam
#6
Do Thi Vinh, Ho Thi Hien, Nguyen Manh Tri, Do Khac Huynh
We conducted a cross-sectional study among 148 women who were regular sexual partners of male injecting drug users in Tien Du, Bac Ninh province, Vietnam to identify the rate of HIV infection and factors associated with HIV transmission among them. HIV infection rate among sexual partners was high, 11.5%. Sexual violence was prevalent, 63.5% among sexual partners; 94.1% (16/17) among those with HIV. We discovered an association between sexual violence and HIV infection. Sexual partners suffering from sexual violence caused by their regular sexual partners faced 9...
January 9, 2018: Health Care for Women International
https://www.readbyqxmd.com/read/29310048/alcohol-operant-self-administration-investigating-how-alcohol-seeking-behaviors-predict-drinking-in-mice-using-two-operant-approaches
#7
Mariah B Blegen, Daniel da Silva E Silva, Roland Bock, Nadege Morisot, Dorit Ron, Veronica A Alvarez
Alcohol operant self-administration paradigms are critical tools for studying the neural circuits implicated in both alcohol-seeking and consummatory behaviors and for understanding the neural basis underlying alcohol-use disorders. In this study, we investigate the predictive value of two operant models of oral alcohol self-administration in mice, one in which alcohol is delivered into a cup following nose-poke responses with no accurate measurement of consumed alcohol solution, and another paradigm that provides access to alcohol via a sipper tube following lever presses and where lick rate and consumed alcohol volume can be measured...
August 19, 2017: Alcohol
https://www.readbyqxmd.com/read/29309081/chicken-breast-muscle-hydrolysates-ameliorate-acute-alcohol-induced-liver-injury-in-mice-through-alcohol-dehydrogenase-adh-activation-and-oxidative-stress-reduction
#8
Chuqiao Xiao, Feibai Zhou, Mouming Zhao, Guowan Su, Baoguo Sun
In this study, the ameliorative effect of chicken breast muscle hydrolysates (CBMHs) against acute alcohol-induced liver injury was investigated and its probable mechanism was further elucidated. In vitro studies clearly showed that CBMHs are able to activate alcohol metabolic enzymes (i.e. alcohol dehydrogenase, ADH) in an exponential manner. Meanwhile, an in vivo experiment on male NIH mice indicated that the oral administration of CBMHs (150, 300 and 600 mg per kg bw) 30 min prior to acute alcohol ingestion could significantly promote alcohol metabolism as revealed by the reduced duration of the loss of righting reflex (LORR) and the enhanced activity of alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH) in the liver, the latter accelerating alcohol oxidation and therefore the decreased blood alcohol concentration (BAC) level...
January 8, 2018: Food & Function
https://www.readbyqxmd.com/read/29307138/mismm-an-integrated-pipeline-for-misassembly-detection-using-genotyping-by-sequencing-and-its-validation-with-bac-end-library-sequences-and-gene-synteny
#9
Young-Joon Ko, Jung Sun Kim, Sangsoo Kim
As next-generation sequencing technologies have advanced, enormous amounts of whole-genome sequence information in various species have been released. However, it is still difficult to assemble the whole genome precisely, due to inherent limitations of short-read sequencing technologies. In particular, the complexities of plants are incomparable to those of microorganisms or animals because of whole-genome duplications, repeat insertions, and Numt insertions, etc. In this study, we describe a new method for detecting misassembly sequence regions of Brassica rapa with genotyping-by-sequencing, followed by MadMapper clustering...
December 2017: Genomics & Informatics
https://www.readbyqxmd.com/read/29305304/sleeve-gastrectomy-surgery-when-2-alcoholic-drinks-are-converted-to-4
#10
María Belén Acevedo, J Christopher Eagon, Bruce D Bartholow, Samuel Klein, Kathleen K Bucholz, Marta Yanina Pepino
BACKGROUND: While it is well established that Roux-en-Y gastric bypass (RYGB) causes a rapid and heightened peak blood alcohol concentration (BAC), results from previous studies on the effects of sleeve gastrectomy (SG) on alcohol pharmacokinetics are conflicting. Data from 2 studies found SG did not affect BAC, whereas another study found SG caused a heightened peak BAC after alcohol ingestion. Moreover, these 3 studies estimated BAC from breathalyzers, which might not reliably estimate peak BAC...
November 10, 2017: Surgery for Obesity and related Diseases: Official Journal of the American Society for Bariatric Surgery
https://www.readbyqxmd.com/read/29302920/a-balanced-reciprocal-translocation-t-10-15-q22-3-q26-1-interrupting-acan-gene-in-a-family-with-proportionate-short-stature
#11
M Crippa, S Giangiobbe, R Villa, I Bestetti, T De Filippis, L Fatti, J Taurino, L Larizza, L Persani, F Bellini, P Finelli, M T Bonati
PURPOSE: Few examples of the involvement of a single gene in idiopathic short stature have been described until now. Our aim was to identify the causative gene of proportionate short stature in a large family showing co-segregation of the phenotype with the reciprocal translocation t(10;15)(q22;q24). METHODS: FISH mapping was carried out with BACs and long-range PCR probes to identify the smallest genomic regions harboring the translocation breakpoints. Real-Time RT-PCR was performed in blood after pre-amplification of target genes cDNA...
January 4, 2018: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/29302849/low-vs-high-alcohol-central-benefits-vs-detriments
#12
REVIEW
Yousef Tizabi, Bruk Getachew, Clifford L Ferguson, Antonei B Csoka, Karl M Thompson, Alejandra Gomez-Paz, Jana Ruda-Kucerova, Robert E Taylor
The dose-dependent effects of alcohol, where the initial euphoric and stimulant effects initiated by the exposure to low ethanol levels can quickly lead to a deadly consequence are well established. Thus, high blood alcohol concentration (BAC), as seen in alcoholics, can cause significant damage to various organs. At low concentrations (e.g., 10 mg% or lower), however, beneficial effects of alcohol, particularly on cardiovascular function have been reported. Although, the latter assertion has been challenged by recent epidemiological studies, protective effects of low alcohol concentrations in vitro and in vivo relevant to the central nervous system (CNS) is well documented...
January 4, 2018: Neurotoxicity Research
https://www.readbyqxmd.com/read/29301233/analyses-of-tissue-culture-adaptation-of-human-herpesvirus-6a-by-whole-genome-deep-sequencing-redefines-the-reference-sequence-and-identifies-virus-entry-complex-changes
#13
Joshua G Tweedy, Eric Escriva, Maya Topf, Ursula A Gompels
Tissue-culture adaptation of viruses can modulate infection. Laboratory passage and bacterial artificial chromosome (BAC)mid cloning of human cytomegalovirus, HCMV, resulted in genomic deletions and rearrangements altering genes encoding the virus entry complex, which affected cellular tropism, virulence, and vaccine development. Here, we analyse these effects on the reference genome for related betaherpesviruses, Roseolovirus, human herpesvirus 6A (HHV-6A) strain U1102. This virus is also naturally "cloned" by germline subtelomeric chromosomal-integration in approximately 1% of human populations, and accurate references are key to understanding pathological relationships between exogenous and endogenous virus...
December 31, 2017: Viruses
https://www.readbyqxmd.com/read/29296788/mll-af9-leukemias-are-sensitive-to-parp1-inhibitors-combined-with-cytotoxic-drugs
#14
Silvia Maifrede, Esteban Martinez, Margaret Nieborowska-Skorska, Daniela Di Marcantonio, Michael Hulse, Bac Viet Le, Huaqing Zhao, Katarzyna Piwocka, Italo Tempera, Stephen M Sykes, Tomasz Skorski
PARP1 is required for the maintenance of MLL-AF9 leukemias.PARP1 inhibitors enhance the therapeutic effect of cytotoxic drugs against MLL-AF9 leukemias.
August 22, 2017: Blood Advances
https://www.readbyqxmd.com/read/29295808/a-perioperative-ehealth-program-to-enhance-postoperative-recovery-after-abdominal-surgery-process-evaluation-of-a-randomized-controlled-trial
#15
Eva van der Meij, Judith Af Huirne, A Dorien Ten Cate, Hein Bac Stockmann, Piet C Scholten, Paul Hp Davids, H Jaap Bonjer, Johannes R Anema
BACKGROUND: Electronic health (eHealth) interventions have proven effective, but implementation in clinical practice is difficult. More research focusing on the implementation process of eHealth interventions is necessary. OBJECTIVE: The objective of this study was to describe the process evaluation of a perioperative eHealth intervention, aiming to enhance recovery after laparoscopic abdominal surgery. METHODS: A process evaluation was carried out alongside a multicenter randomized controlled trial...
January 2, 2018: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/29291548/drivers-with-alcohol-use-disorders-and-their-risks-of-crash-involvement
#16
Jie Yao, Robert B Voas, John H Lacey
BACKGROUND: The relationship between driver blood alcohol concentration (BAC) and crash involvement is well understood. However, the role of alcohol use disorders (AUDs) (i.e., dependence or abuse) in crash occurrence, as distinguished from non-clinical heavy alcohol consumption, has not been adequately explored. METHODS: Data from the 2010-2011 Crash Risk Study conducted in Virginia Beach, VA, were used in this study. Drivers involved in crashes were compared with control drivers, and four drinker groups were examined: alcohol dependent, alcohol abusers, heavy drinkers, and all other current (i...
December 27, 2017: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/29291505/the-effects-of-alcohol-on-heartbeat-perception-implications-for-anxiety
#17
Kenneth Abrams, Kate Cieslowski, Stacey Johnson, Sam Krimmel, Gabby Bierlein-De La Rosa, Kirstie Barton, Pombie Silverman
INTRODUCTION: It is well established that some individuals self-medicate their anxiety with alcohol. Though much evidence exists that alcohol consumption can be negatively reinforcing, there remains uncertainty regarding what mediates the relationship between alcohol and anxiety. An unexplored possibility is that, for some, alcohol impairs interoceptive sensitivity (the ability to accurately perceive one's physiological state), thereby decreasing state anxiety. Consistent with this, highly accurate heartbeat perception is a risk factor both for elevated trait anxiety and anxiety disorders...
December 20, 2017: Addictive Behaviors
https://www.readbyqxmd.com/read/29288830/a-standardized-extract-of-rhynchosia-volubilis-lour-exerts-a-protective-effect-on-benzalkonium-chloride-induced-mouse-dry-eye-model
#18
Suk Woo Kang, Kyung-A Kim, Chung Hyun Lee, Sung Jae Yang, Tae Kyeom Kang, Je Hyeong Jung, Tae-Jin Kim, Sang-Rok Oh, Sang Hoon Jung
ETHNOPHARMACOLOGICAL RELEVANCE: In contrast to other leguminous plants generally used as food, Rhynchosia volubilis Loureiro, a small soybean with a black seed coat, has been used as a traditional oriental remedy for various human diseases in Eastern Asia. In this study, we demonstrated the protective effect of R. volubilis against dry eye disease. AIM OF THE STUDY: We aimed to investigate whether a standardized ethanol extract of R. volubilis (EERV) can protect the cornea in a benzalkonium chloride (BAC)-induced mouse dry eye model...
December 27, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29283075/evaluation-of-farnesoid-x-receptor-target-gene-induction-in-human-hepatocytes-amino-acid-conjugation
#19
Jean Simmermacher, Michael Sinz
BACKGROUND: The nuclear hormone receptor, farnesoid X receptor (FXR) regulates the transcription of genes associated with bile acid metabolism and disposition. OBJECTIVE: This study investigates possible changes in the expression of target genes responsible for amino acid conjugation, i.e., bile acid-CoA synthetase (BACS) and bile acid-CoA: amino acid N-acetyltransferase (BAT). These genes have been shown to be inducible by FXR agonists in rat models, however, to date no studies have been conducted in a human hepatocyte model...
December 27, 2017: Drug Metabolism Letters
https://www.readbyqxmd.com/read/29282233/ethanol-forensic-toxicology
#20
Paul J Perry, Shadi Doroudgar, Priscilla Van Dyke
Ethanol abuse can lead to negative consequences that oftentimes result in criminal charges and civil lawsuits. When an individual is suspected of driving under the influence, law enforcement agents can determine the extent of intoxication by measuring the blood alcohol concentration (BAC) and performing a standardized field sobriety test. The BAC is dependent on rates of absorption, distribution, and elimination, which are influenced mostly by the dose of ethanol ingested and rate of consumption. Other factors contributing to BAC are gender, body mass and composition, food effects, type of alcohol, and chronic alcohol exposure...
December 2017: Journal of the American Academy of Psychiatry and the Law
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