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https://www.readbyqxmd.com/read/28805610/validation-of-a-high-throughput-and-robust-technique-bacs-on-beads-assay-karyolite-bobs-for-pre-implantation-aneuploidy-screening
#1
Grace Wing Shan Kong, Yanlin Ma, Jian Ou, Yvonne Ka Yin Kwok, Wei Wang, Queenie Sum Yee Yeung, Cherry Kit Man Wong, Qi Li, Wen Xu, Weiying Lu, Hong Li, Tin Chiu Li, Kwong Wai Choy
OBJECTIVE: This study aims to validate the BACs-on-Beads (BoB) technology as a robust and high throughput method for pre-implantation genetic screening (PGS) for aneuploidy. MATERIAL AND METHODS: The performances with respect to the sensitivity, specificity, success rate and detection rate of this technique from new BoBs technology and traditional array chromosomal genomic hybridization (aCGH) were compared. And the use of BoBs as a screening tool for euploid embryos in PGS was evaluated...
August 2017: Taiwanese Journal of Obstetrics & Gynecology
https://www.readbyqxmd.com/read/28801183/paired-phase-ii-studies-of-erlotinib-bevacizumab-for-advanced-bronchioloalveolar-carcinoma-or-never-smokers-with-advanced-non-small-cell-lung-cancer-swog-s0635-and-s0636-trials
#2
Howard L West, James Moon, Antoinette J Wozniak, Philip Mack, Fred R Hirsch, Martin J Bury, Myron Kwong, Dorothy D Nguyen, Dennis F Moore, Jieling Miao, Mary Redman, Karen Kelly, David R Gandara
BACKGROUND: Before mutation testing of the epidermal growth factor receptor (EGFR) gene was recognized as highly associated with the activity of EGFR tyrosine kinase inhibitors (TKIs), clinically defined patient populations with bronchioloalveolar carcinoma (BAC) and never smokers were identified as likely to benefit from EGFR TKIs. From preclinical and clinical data suggesting potentially improved efficacy with a combination of an EGFR TKI and the antiangiogenic agent bevacizumab, the Southwestern Oncology Group (SWOG) initiated paired phase II trials to evaluate the combination of erlotinib/bevacizumab in patients with advanced BAC (SWOG S0635) or never smokers with advanced lung adenocarcinoma (SWOG S0636)...
July 6, 2017: Clinical Lung Cancer
https://www.readbyqxmd.com/read/28801044/cationic-ionic-liquid-surfactant-polyacrylamide-gel-electrophoresis-for-enhanced-separation-of-acidic-and-basic-proteins-with-single-step-ribonuclease-b-glycoforms-separation
#3
Punprabhashi Vidanapathirana, Farhana Hasan, Kaitlyn Mussio, Anuja Pande, Michael Brands, Noureen Siraj, Anne Grove, Isiah M Warner
Cationic ionic liquids-based surfactants (ILS), such as 4-methyl pyridinium bromide (CnPBr, where n=4,6,8), were used in preparation of polyacrylamide gels, sample buffer, and running buffer for cationic ILS polyacrylamide gel electrophoresis (ILS-PAGE). These ILS are liquids in the pure state and were selected for improved separation of ribonuclease b (Rib b) glycoforms in a single step and a protein mixture containing bovine serum albumin (BSA, pI-4.8, 66.5kDa), ovalbumin (Ova, pI-4.6, 44.3kDa), α-chymotrypsinogen (α-Chy, pI-8...
July 29, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/28789633/variations-in-5s-rdnas-in-diploid-and-tetraploid-offspring-of-red-crucian-carp-%C3%A3-common-carp
#4
Lihai Ye, Chun Zhang, Xiaojun Tang, Yiyi Chen, Shaojun Liu
BACKGROUND: The allotetraploid hybrid fish (4nAT) that was created in a previous study through an intergeneric cross between red crucian carp (Carassius auratus red var., ♀) and common carp (Cyprinus carpio L., ♂) provided an excellent platform to investigate the effect of hybridization and polyploidization on the evolution of 5S rDNA. The 5S rDNAs of paternal common carp were made up of a coding sequence (CDS) and a non-transcribed spacer (NTS) unit, and while the 5S rDNAs of maternal red crucian carp contained a CDS and a NTS unit, they also contained a variable number of interposed regions (IPRs)...
August 8, 2017: BMC Genetics
https://www.readbyqxmd.com/read/28783792/comparison-of-the-performance-of-different-microbial-source-tracking-markers-among-european-and-north-african-regions
#5
Mariem Yahya, Anicet R Blanch, Wim G Meijer, Katerina Antoniou, Fatma Hmaied, Elisenda Ballesté
Microbial source tracking (MST) has been extensively used to detect the sources of fecal pollution in water. The inclusion of MST in water management strategies improves the ecological status of the ecosystem and human and animal health under interdisciplinary analysis in all aspects of health care for humans, animals, and the environment (One Health approach). In this study, the performance of MST markers targeting host-specific Bacteroidales (HF183 and Rum-2-Bac) and species (HMBif and CWBif) were evaluated in raw sewage collected from human, ruminant, swine, and poultry sources in Tunisia, Cyprus, Ireland, and Spain...
July 2017: Journal of Environmental Quality
https://www.readbyqxmd.com/read/28783544/the-effects-of-licence-disqualification-on-drink-drivers-is-it-the-same-for-everyone
#6
A Watson, J Freeman, K Imberger, A J Filtness, H Wilson, D Healy, A Cavallo
Drink-driving remains a major road safety concern that creates a significant social burden. Licence disqualification continues to play a key role in drink driving deterrence and sanctions together with police enforcement to address the problem in most motorised countries. However, on-going questions remain regarding the differing effect of licence disqualification periods between first time and repeat offenders, and between other sub-groups of offenders. As a result, this study aimed to determine whether: (a) differences exist in re-offence rates of convicted drink-drivers between: the period between committing the drink-driving offence and licence disqualification (pre-licence disqualification), during the period of licence disqualification, and after being re-licensed (post-licence restoration); and (b) differential effects of offence rates are evident based on Blood Alcohol Content (BAC), gender, age, repeat offender status and crash involvement at the time of offence...
August 4, 2017: Accident; Analysis and Prevention
https://www.readbyqxmd.com/read/28777855/-application-of-bacs-on-beads-and-karyotyping-for-the-prenatal-diagnosis-of-1371-pregnant-women-with-a-high-risk
#7
Penglong Chen, Chunlei Jin, Qunda Shan, Bixia Qian, Xiaohong Zheng, Xiaohong Wang, Yi Wang
OBJECTIVE: To assess the value of combined BACs-on-Beads(TM) (BoBs) and chromosomal karyotyping for the diagnosis of women with high-risk pregnancy. METHODS: For 1371 women with singleton pregnancy and various indications for prenatal diagnosis, karyotyping and BoBs were simultaneously applied on their amnionic fluid samples. RESULTS: In total 23 cases of trisomy 21, 11 cases of trisomy 18, 5 cases of sex chromosome aneuploidies, 6 cases of microdeletions/microduplications, 2 cases of chimeric chromosomes and 1 case of structural chromosomal abnormality were detected by the BoBs assay, among which the 6 microdeletions/microduplications were not detected by karyotyping...
August 10, 2017: Zhonghua Yi Xue Yi Chuan Xue za Zhi, Zhonghua Yixue Yichuanxue Zazhi, Chinese Journal of Medical Genetics
https://www.readbyqxmd.com/read/28774623/control-of-aliphatic-halogenated-dbp-precursors-with-multiple-drinking-water-treatment-processes-formation-potential-and-integrated-toxicity
#8
Yimeng Zhang, Wenhai Chu, Dechang Yao, Daqiang Yin
The comprehensive control efficiency for the formation potentials (FPs) of a range of regulated and unregulated halogenated disinfection by-products (DBPs) (including carbonaceous DBPs (C-DBPs), nitrogenous DBPs (N-DBPs), and iodinated DBPs (I-DBPs)) with the multiple drinking water treatment processes, including pre-ozonation, conventional treatment (coagulation-sedimentation, pre-sand filtration), ozone-biological activated carbon (O3-BAC) advanced treatment, and post-sand filtration, was investigated. The potential toxic risks of DBPs by combing their FPs and toxicity values were also evaluated...
August 2017: Journal of Environmental Sciences (China)
https://www.readbyqxmd.com/read/28771134/evaluation-of-the-cobas-u-701-microscopy-analyser-compared-with-urine-culture-in-screening-for-urinary-tract-infection
#9
Si Hyun Kim, Sae Am Song, Sang-Hwa Urm, Joong-Ki Kook, Hye Ran Kim, Dongeun Yong, Jun Yong Choi, Jeong Hwan Shin
PURPOSE: A new automated Cobas u 701 microscopy analyser for urine sediment examination was introduced. The aim of this study was to evaluate the analyser in comparison with urine culture in screening for urinary tract infection (UTI). METHODOLOGY: A total of 852 urine specimens submitted for culture were included in this study. Urine sediment examination was performed using the Cobas u 701 microscopy analyser. The results of the bacteria (BAC) and yeast (YEA) analyses were compared with the results from urine culture as a method for UTI screening...
August 4, 2017: Journal of Medical Microbiology
https://www.readbyqxmd.com/read/28769787/a-combination-of-ex-vivo-diffusion-mri-and-multiphoton-to-study-microglia-monocytes-alterations-after-spinal-cord-injury
#10
Harun N Noristani, Hassan Boukhaddaoui, Guillaume Saint-Martin, Pauline Auzer, Rahima Sidiboulenouar, Nicolas Lonjon, Eric Alibert, Nicolas Tricaud, Christophe Goze-Bac, Christophe Coillot, Florence E Perrin
Central nervous system (CNS) injury has been observed to lead to microglia activation and monocytes infiltration at the lesion site. Ex vivo diffusion magnetic resonance imaging (diffusion MRI or DWI) allows detailed examination of CNS tissues, and recent advances in clearing procedures allow detailed imaging of fluorescent-labeled cells at high resolution. No study has yet combined ex vivo diffusion MRI and clearing procedures to establish a possible link between microglia/monocytes response and diffusion coefficient in the context of spinal cord injury (SCI)...
2017: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/28766050/unique-xci-evolution-in-tokudaia-initial-xci-of-the-neo-x-chromosome-in-tokudaia-muenninki-and-function-loss-of-xist-in-tokudaia-osimensis
#11
Hideki Zushi, Chie Murata, Shusei Mizushima, Chizuko Nishida, Asato Kuroiwa
X chromosome inactivation (XCI) is an essential mechanism to compensate gene dosage in mammals. Here, we show that XCI has evolved differently in two species of the genus Tokudaia. The Amami spiny rat, Tokudaia osimensis, has a single X chromosome in males and females (XO/XO). By contrast, the Okinawa spiny rat, Tokudaia muenninki, has XX/XY sex chromosomes like most mammals, although the X chromosome has acquired a neo-X region by fusion with an autosome. BAC clones containing the XIST gene, which produces the long non-coding RNA XIST required for XCI, were obtained by screening of T...
August 2, 2017: Chromosoma
https://www.readbyqxmd.com/read/28756515/reconstruction-of-chromosome-rearrangements-between-the-two-most-ancestral-duckweed-species-spirodela-polyrhiza-and-s-intermedia
#12
Phuong T N Hoang, Ingo Schubert
The monophyletic duckweeds comprising five genera within the monocot order Alismatales are neotenic, free-floating, aquatic organisms with fast vegetative propagation. Some species are considered for efficient biomass production, for life stock feeding, and for (simultaneous) wastewater phytoremediation. The ancestral genus Spirodela consists of only two species, Spirodela polyrhiza and Spirodela intermedia, both with a similar small genome (~160 Mbp/1C). Reference genome drafts and a physical map of 96 BACs on the 20 chromosome pairs of S...
July 29, 2017: Chromosoma
https://www.readbyqxmd.com/read/28755401/association-between-the-scores-of-the-japanese-version-of-the-brief-assessment-of-cognition-in-schizophrenia-and-whole-brain-structure-in-patients-with-chronic-schizophrenia-a-voxel-based-morphometry-and-diffusion-tensor-imaging-study
#13
Shinsuke Hidese, Miho Ota, Junko Matsuo, Ikki Ishida, Moeko Hiraishi, Toshiya Teraishi, Kotaro Hattori, Hiroshi Kunugi
AIM: The brief assessment of cognition in schizophrenia (BACS) is a concise tool designed to evaluate cognitive deficits in schizophrenia. We examined the possible association between BACS scores and whole-brain structure, as observed using magnetic resonance imaging (MRI) with a relatively large sample. METHODS: The study sample comprised 116 patients with schizophrenia (mean age, 39.3 ± 11.1 years; 66 men) and 118 healthy controls (40.0 ± 13.6; 58 men) who completed the Japanese version of the BACS (BACS-J)...
July 29, 2017: Psychiatry and Clinical Neurosciences
https://www.readbyqxmd.com/read/28754135/retrofitting-the-bac-cloning-vector-pbelobac11-by-the-insertion-of-a-mutant-loxp-site
#14
Jonathon S Coren
OBJECTIVE: Human genomic libraries constructed in bacterial artificial chromosome vectors were utilized to make physical maps of all 23-chromosome pairs and as the templates for DNA sequencing to aid in the completion of the Human Genome Project. The goal of this study was to modify the BAC vector pBeloBAC11 so that genomic inserts contained in this vector could be subjected to bidirectional transposon-mediated nested deletions from the wild-type and mutant loxP sites present. RESULTS: An oligonucleotide containing a mutant loxP 2272 site and a XhoI restriction enzyme sequence was designed and inserted at the SfiI restriction site located approximately 200 basepairs upstream of the lacZ gene in pBeloBAC11...
July 28, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/28752866/alginate-based-hydrogels-functionalised-at-the-nanoscale-using-layer-by-layer-assembly-for-potential-cartilage-repair
#15
P Gentile, C Ghione, A M Ferreira, A Crawford, P V Hatton
Injuries to articular cartilage are frequently difficult to repair, in part because of the poor regenerative capacity of this tissue. To date, no successful system for complete regeneration of the most challenging cartilage defects has been demonstrated. The aim of this work was to develop functionalised hydrogels at the nanoscale by Layer-by-Layer (LbL) assembly to promote cartilage healing. Hydrogels, based on sodium alginate (NaAlg) and gelatin (G), were prepared by an external gelation method consisting of CaCl2 diffusion and genipin addition for G crosslinking...
July 28, 2017: Biomaterials Science
https://www.readbyqxmd.com/read/28740828/omega-3-fatty-acids-related-to-cognitive-impairment-in-patients-with-schizophrenia
#16
Kazumi Satogami, Shun Takahashi, Shinichi Yamada, Satoshi Ukai, Kazuhiro Shinosaki
Cognitive impairment is strongly associated with functional outcome in patients with schizophrenia but its pathophysiology remains largely unclear. Involvement of omega-3 fatty acids in the cognitive function of healthy individuals and patients with neuropsychiatric disease has received increasing attention. The aim of this study was to examine the relationship between omega-3 fatty acids with cognitive function, social function, and psychiatric symptoms in patients with schizophrenia. The subjects included 30 patients with schizophrenia or schizoaffective disorder...
September 2017: Schizophrenia Research. Cognition
https://www.readbyqxmd.com/read/28740824/associations-between-daily-living-skills-cognition-and-real-world-functioning-across-stages-of-schizophrenia-a-study-with-the-schizophrenia-cognition-rating-scale-japanese-version
#17
Yuko Higuchi, Tomiki Sumiyoshi, Tomonori Seo, Motomu Suga, Tsutomu Takahashi, Shimako Nishiyama, Yuko Komori, Kiyoto Kasai, Michio Suzuki
Cognitive function is impaired in patients with schizophrenia-spectrum disorders, even in their prodromal stages. Specifically, the assessment of cognitive abilities related to daily-living functioning, or functional capacity, is important to predict long-term outcome. In this study, we sought to determine the validity of the Schizophrenia Cognition Rating Scale (SCoRS) Japanese version, an interview-based measure of cognition relevant to functional capacity (i.e. co-primary measure). For this purpose, we examined the relationship of SCoRS scores with performance on the Brief Assessment of Cognition in Schizophrenia (BACS) Japanese version, a standard neuropsychological test battery, and the Social and Occupational Functioning Assessment Scale (SOFAS), an interview-based social function scale...
March 2017: Schizophrenia Research. Cognition
https://www.readbyqxmd.com/read/28740819/cognitive-insight-and-functional-outcome-in-schizophrenia-a-multi-center-collaborative-study-with-the-specific-level-of-functioning-scale-japanese-version
#18
Tomiki Sumiyoshi, Keiichiro Nishida, Hidehito Niimura, Atsuhito Toyomaki, Tsubasa Morimoto, Masayuki Tani, Ken Inada, Taiga Ninomiya, Hikaru Hori, Jun Manabe, Asuka Katsuki, Takamitsu Kubo, Yosuke Koshikawa, Masanao Shirahama, Kentaro Kohno, Toshihiko Kinoshita, Ichiro Kusumi, Akira Iwanami, Takefumi Ueno, Toshi Kishimoto, Takeshi Terao, Kazuyuki Nakagome
The Specific Levels of Functioning Scale (SLOF) has been reported to provide a measure of social function in patients with schizophrenia. The aim of this multi-center study was to determine convergent validity of the Japanese version of SLOF, and if cognitive insight would be associated with social function. Fifty-eight patients with schizophrenia participated in the study. Social function, neurocognition, and daily activity skills were evaluated by the Social Functioning Scale (SFS), Brief Assessment of Cognition in Schizophrenia (BACS) and UCSD Performance-based Skills Assessment-Brief (UPSA-B), respectively...
December 2016: Schizophrenia Research. Cognition
https://www.readbyqxmd.com/read/28738197/tracking-changes-in-composition-and-amount-of-dissolved-organic-matter-throughout-drinking-water-treatment-plants-by-comprehensive-two-dimensional-gas-chromatography-quadrupole-mass-spectrometry
#19
Chunmei Li, Donghong Wang, Xiong Xu, Meijia Xu, Zijian Wang, Ruiyang Xiao
Dissolved organic matter (DOM) can affect the performance of water treatment processes and produce undesirable disinfection by-products during disinfection. Several studies have been undertaken on the structural characterization of DOM, but its fate during drinking water treatment processes is still not fully understood. In this work, the nontargeted screening method of comprehensive two-dimensional gas chromatography-quadrupole mass spectrometry (GC×GC-qMS) was used to reveal the detailed changes of different chemical classes of compounds in DOM during conventional and advanced drinking water treatment processes at three drinking water treatment plants in China...
July 21, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28732463/common-and-phylogenetically-widespread-coding-for-peptides-by-bacterial-small-rnas
#20
Robin C Friedman, Stefan Kalkhof, Olivia Doppelt-Azeroual, Stephan A Mueller, Martina Chovancová, Martin von Bergen, Benno Schwikowski
BACKGROUND: While eukaryotic noncoding RNAs have recently received intense scrutiny, it is becoming clear that bacterial transcription is at least as pervasive. Bacterial small RNAs and antisense RNAs (sRNAs) are often assumed to be noncoding, due to their lack of long open reading frames (ORFs). However, there are numerous examples of sRNAs encoding for small proteins, whether or not they also have a regulatory role at the RNA level. METHODS: Here, we apply flexible machine learning techniques based on sequence features and comparative genomics to quantify the prevalence of sRNA ORFs under natural selection to maintain protein-coding function in 14 phylogenetically diverse bacteria...
July 21, 2017: BMC Genomics
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