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https://www.readbyqxmd.com/read/28086778/diabetes-does-not-impact-the-diagnostic-performance-of-contrast-based-fractional-flow-reserve-insights-from-the-contrast-study
#1
Giuseppe Gargiulo, Eugenio Stabile, Marco Ferrone, Emanuele Barbato, Frederik M Zimmermann, Julien Adjedj, Barry Hennigan, Mitsuaki Matsumura, Nils P Johnson, William F Fearon, Allen Jeremias, Bruno Trimarco, Giovanni Esposito
BACKGROUND: Adenosine-free coronary pressure wire metrics have been proposed to test the functional significance of coronary artery lesions, but it is unexplored whether their diagnostic performance might be altered in patients with diabetes. METHODS: We performed a post-hoc analysis of the CONTRAST study, which prospectively enrolled an international cohort of patients undergoing routine fractional flow reserve (FFR) assessment for standard indications. Paired, repeated measurements of all physiology metrics (Pd/Pa, iFR, contrast-based FFR, and FFR) were made...
January 13, 2017: Cardiovascular Diabetology
https://www.readbyqxmd.com/read/28047187/tu-h-campus-iep2-03-development-of-3d-printed-coronary-phantoms-for-in-vitro-ct-ffr-validation-using-data-from-320-detector-row-coronary-ct-angiography
#2
C Ionita, E Angel, D Mitsouras, S Rudin, D Bednarek, S Zaid, M Wilson, F Rybicki
PURPOSE: To validate Computed Tomography Fractional Flow Reserve (CT-FFR) measurements with accurate 3D printed coronary phantoms. METHODS: DICOM data from four phases in two patients imaged with a standard 320 × 0.5mm coronary CT acquisition (70-80% cardiac cycle) underwent semi-automated segmentation using a research workstation. Both patients had a >50% stenosis from the clinical image interpretation. Each volume was saved as a Stereo Lithographic (STL) file with 250 micron resolution...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28043881/simultaneously-evoked-auditory-potentials-seap-a-new-method-for-concurrent-measurement-of-cortical-and-subcortical-auditory-evoked-activity
#3
Christopher Slugocki, Daniel Bosnyak, Laurel J Trainor
Recent electrophysiological work has evinced a capacity for plasticity in subcortical auditory nuclei in human listeners. Similar plastic effects have been measured in cortically-generated auditory potentials but it is unclear how the two interact. Here we present Simultaneously-Evoked Auditory Potentials (SEAP), a method designed to concurrently elicit electrophysiological brain potentials from inferior colliculus, thalamus, and primary and secondary auditory cortices. Twenty-six normal-hearing adult subjects (mean 19...
December 30, 2016: Hearing Research
https://www.readbyqxmd.com/read/28013282/fractional-flow-reserve-derived-from-coronary-computed-tomography-angiography-diagnostic-performance-in-hypertensive-and-diabetic-patients
#4
Ashkan Eftekhari, James Min, Stephan Achenbach, Mohamed Marwan, Matthew Budoff, Jonathon Leipsic, Sara Gaur, Jesper Møller Jensen, Brian S Ko, Evald Høj Christiansen, Anne Kaltoft, Hans Erik Bøtker, Jens Flensted Jensen, Bjarne Linde Nørgaard
AIMS: Fractional flow reserve (FFR) derived from coronary computed tomography (FFRCT) has high diagnostic performance in stable coronary artery disease (CAD). The diagnostic performance of FFRCT in patients with hypertension (HTN) and diabetes (DM), who are at risk of microvascular impairment, is not known. METHODS AND RESULTS: We analysed the diagnostic performance of FFRCT, in patients (vessels) with DM (n = 16), HTN (n = 186), DM + HTN (n = 58) vs...
December 24, 2016: European Heart Journal Cardiovascular Imaging
https://www.readbyqxmd.com/read/28007742/invasive-minimal-microvascular-resistance-is-a-new-index-to-assess-microcirculatory-function-independent-of-obstructive-coronary-artery-disease
#5
Guus A de Waard, Sukhjinder S Nijjer, Martijn A van Lavieren, Nina W van der Hoeven, Ricardo Petraco, Tim P van de Hoef, Mauro Echavarría-Pinto, Sayan Sen, Peter M van de Ven, Paul Knaapen, Javier Escaned, Jan J Piek, Justin E Davies, Niels van Royen
BACKGROUND: Coronary microcirculatory dysfunction portends a poor cardiovascular outcome. Invasive assessment of microcirculatory dysfunction by coronary flow reserve (CFR) and hyperemic microvascular resistance (HMR) is affected by coronary artery disease (CAD). In this study we propose minimal microvascular resistance (mMR) as a new measure of microcirculatory dysfunction and aim to determine whether mMR is influenced by CAD. METHODS AND RESULTS: We obtained 482 simultaneous measurements of intracoronary Doppler flow velocity and pressure...
December 22, 2016: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28004229/patient-specific-3d-hemodynamics-modelling-of-left-coronary-artery-under-hyperemic-conditions
#6
Sarfaraz Kamangar, Irfan Anjum Badruddin, Kalimuthu Govindaraju, N Nik-Ghazali, A Badarudin, Girish N Viswanathan, N J Salman Ahmed, T M Yunus Khan
The purpose of this study is to investigate the effect of various degrees of percentage stenosis on hemodynamic parameters during the hyperemic flow condition. 3D patient-specific coronary artery models were generated based on the CT scan data using MIMICS-18. Numerical simulation was performed for normal and stenosed coronary artery models of 70, 80 and 90% AS (area stenosis). Pressure, velocity, wall shear stress and fractional flow reserve (FFR) were measured and compared with the normal coronary artery model during the cardiac cycle...
December 21, 2016: Medical & Biological Engineering & Computing
https://www.readbyqxmd.com/read/27998839/ffr-result-post-pci-is-suboptimal-in-long-diffuse-coronary-artery-disease
#7
Arvydas Baranauskas, Aaron Peace, Aleksandras Kibarskis, Joanne Shannon, Vytautas Abraitis, Vilhelmas Bajoras, Valdas Bilkis, Audrius Aidietis, Aleksandras Laucevicius, Giedrius Davidavicius
AIMS: The aim of this study was to evaluate the functional result immediately post PCI and at nine-month follow-up, and to ascertain how often a functionally optimal result of >0.95 can be achieved in long coronary lesions treated with long second- or newer-generation DES. METHODS AND RESULTS: Patients receiving DES measuring ≥30 mm with FFR value ≤0.8 were included in the study. Stent length was defined as long (30 to 49 mm; L-DES) and ultra-long (≥50 mm; UL-DES)...
December 20, 2016: EuroIntervention
https://www.readbyqxmd.com/read/27993753/reactive-myocardial-hyperemia-for-functional-assessment-of-coronary-stenosis-severity
#8
Michael Stoller, Christian Seiler
AIM: To compare functional assessment of coronary stenosis severity by fractional flow reserve (FFR) measurement as induced by systemic adenosine and by regional reactive myocardial hyperemia. METHODS AND RESULTS: The primary study endpoints were coronary pressure-derived FFR values in response to intravenous adenosine infusion (140µg/min/kg) and to a 1-minute proximal coronary artery balloon occlusion (reactive hyperemia) for the same stenosis of interest. The secondary study endpoint was coronary collateral flow index (CFI) during the same occlusion...
December 20, 2016: EuroIntervention
https://www.readbyqxmd.com/read/27983573/trends-in-consumption-of-solid-fats-added-sugars-sodium-sugar-sweetened-beverages-and-fruit-from-fast-food-restaurants-and-by-fast-food-restaurant-type-among-us-children-2003-2010
#9
Colin D Rehm, Adam Drewnowski
Energy intakes from fast food restaurants (FFRs) have declined among US children. Less is known about the corresponding trends for FFR-sourced solid fats, added sugars, and sodium, and food groups of interest, such as fruit and sugar-sweetened beverages (SSBs). Using data from a single 24-h dietary recall among 12,378 children aged 4-19 years from four consecutive cycles of the nationally-representative National Health and Nutrition Examination Survey (NHANES), 2003-2010 a custom algorithm segmented FFRs into burger, pizza, sandwich, Mexican cuisine, chicken, Asian cuisine, fish restaurants, and coffee shops...
December 13, 2016: Nutrients
https://www.readbyqxmd.com/read/27980112/cortical-correlates-of-the-auditory-frequency-following-and-onset-responses-eeg-and-fmri-evidence
#10
Emily B J Coffey, Gabriella Musacchia, Robert J Zatorre
: The frequency following response (FFR) is a measure of the brain's periodic sound encoding. It is of increasing importance for studying the human auditory nervous system due to numerous associations with auditory cognition and dysfunction. Although the FFR is widely interpreted as originating from brainstem nuclei, a recent study using magnetoencephalography (MEG) suggested that there is also a right-lateralized contribution from the auditory cortex at the fundamental frequency (Coffey et al...
December 15, 2016: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/27979031/clinical-value-of-post-percutaneous-coronary-intervention-fractional-flow-reserve-value-a-systematic-review-and-meta-analysis
#11
REVIEW
Goran Rimac, William F Fearon, Bernard De Bruyne, Fumiaki Ikeno, Hitoshi Matsuo, Zsolt Piroth, Olivier Costerousse, Olivier F Bertrand
BACKGROUND: Fractional flow reserve (FFR) prior to percutaneous coronary intervention (PCI) is useful to guide treatment. Whether post-PCI FFR assessment might have clinical impact is controversial. The aim of this study is to evaluate the range of post-PCI FFR values and analyze the relationship between post-PCI FFR and clinical outcomes. METHODS: We systematically searched the PubMed, EMBASE, and Cochrane Library databases with cross-referencing of articles reporting post-PCI FFR and correlating post-PCI FFR values and clinical outcomes...
January 2017: American Heart Journal
https://www.readbyqxmd.com/read/27973333/reliability-of-physiological-assessment-of-coronary-stenosis-severity-using-intracoronary-pressure-techniques-a-comprehensive-analysis-from-a-large-cohort-of-consecutive-intermediate-coronary-lesions
#12
Fernando Rivero, Javier Cuesta, Teresa Bastante, Amparo Benedicto, Cristina Fernández-Pérez, Paula Antuña, Marcos García-Guimaraes, Fernando Alfonso
AIM: We sought to assess the reliability of the most frequently used intracoronary physiologic indexes (including intravenous adenosine-FFR [IV- FFR], intracoronary low-dose-adenosine FFR [IC-LD-FFR], intracoronary high- dose-adenosine FFR [IC-HD-FFR], Pd/Pa and iFR). We also sought to analyze factors affecting their reproducibility in a real world patient population. METHODS AND RESULTS: A total of 91 lesions in 86 consecutive patients were included. Measurements of all physiological indexes were repeated within a systematic standardized prospective protocol...
December 15, 2016: EuroIntervention
https://www.readbyqxmd.com/read/27969905/tct-536-routine-fractional-flow-reserve-measurement-after-percutaneous-coronary-intervention-with-a-novel-ffr-micro-catheter-insights-from-the-ffr-search-registry-ffr-stent-evaluated-at-rotterdam-cardiology-hospital
#13
Rutger van Bommel, Miguel Lemmert, Yan Wang, Joost Daemen, Evelyn Regar, Jeroen Wilschut, Felix Zijlstra, Roberto Diletti, Nicolas Van Mieghem
No abstract text is available yet for this article.
November 1, 2016: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/27965572/voice-pitch-elicited-frequency-following-response-in-chinese-elderlies
#14
Shuo Wang, Jiong Hu, Ruijuan Dong, Dongxin Liu, Jing Chen, Gabriella Musacchia, Bo Liu
Background: Perceptual and electrophysiological studies have found reduced speech discrimination in quiet and noisy environment, delayed neural timing, decreased neural synchrony, and decreased temporal processing ability in elderlies, even those with normal hearing. However, recent studies have also demonstrated that language experience and auditory training enhance the temporal dynamics of sound encoding in the auditory brainstem response (ABR). The purpose of this study was to explore the pitch processing ability at the brainstem level in an aging population that has a tonal language background...
2016: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/27956409/functional-assessment-of-coronary-artery-disease-using-whole-heart-dynamic-computed-tomographic-perfusion
#15
Logan Hubbard, Benjamin Ziemer, Jerry Lipinski, Bahman Sadeghi, Hanna Javan, Elliott M Groves, Shant Malkasian, Sabee Molloi
BACKGROUND: Computed tomographic (CT) angiography is an important tool for the evaluation of coronary artery disease but often correlates poorly with myocardial ischemia. Current dynamic CT perfusion techniques can assess ischemia but have limited accuracy and deliver high radiation dose. Therefore, an accurate, low-dose, dynamic CT perfusion technique is needed. METHODS AND RESULTS: A total of 20 contrast-enhanced CT volume scans were acquired in 5 swine (40±10 kg) to generate CT angiography and perfusion images...
December 2016: Circulation. Cardiovascular Imaging
https://www.readbyqxmd.com/read/27956352/correlation-between-the-frequency-difference-limen-and-an-index-based-on-principal-component-analysis-of-the-frequency-following-response-of-normal-hearing-listeners
#16
Xiaochen Zhang, Qin Gong
Subcortical phase locking tends to reflect performance differences in tasks related to pitch perception across different types of populations. Enhancement or attenuation in its strength may correspond to population excellence or deficiency in pitch perception. However, it is still unclear whether differences in perceptual capability among individuals with normal hearing can be predicted by subcortical phase locking. In this study, we examined the brain-behavior relationship between frequency-following responses (FFRs) evoked by pure/sweeping tones and frequency difference limens (FDLs)...
December 10, 2016: Hearing Research
https://www.readbyqxmd.com/read/27943219/visualization-of-the-improvement-of-myocardial-perfusion-after-coronary-intervention-using-motorized-fractional-flow-reserve-pullback-curve
#17
Akiko Matsuo, Satoshi Shimoo, Kazuaki Takamatsu, Yumika Tsuji, Atsushi Kyodo, Kayoko Mera, Masahiro Koide, Koji Isodono, Yoshinori Tsubakimoto, Tomohiko Sakatani, Keiji Inoue, Hiroshi Fujita
This study aimed to evaluate the feasibility and utility of using motorized pullback of the pressure guidewire to provide a graphic assessment and prediction of the benefits of coronary intervention. Fractional flow reserve (FFR) measurements were performed with motorized pullback imaging in 20 patients who underwent successful percutaneous coronary intervention (PCI) of the left anterior descending artery. Physiological lesion length (PLL) was calculated using frame counts to determine stent length. FFR area was calculated by integrating the FFR values recorded during pullback tracing (FFRarea)...
December 10, 2016: Cardiovascular Intervention and Therapeutics
https://www.readbyqxmd.com/read/27939753/a-head-to-head-comparison-between-ct-and-ivus-derived-coronary-blood-flow-models
#18
C A Bulant, P J Blanco, G D Maso Talou, C Guedes Bezerra, P A Lemos, R A Feijóo
The goal of this work is to compare coronary hemodynamics as predicted by computational blood flow models derived from two imaging modalities: coronary computed tomography angiography (CCTA) and intravascular ultrasound integrated with angiography (IVUS). Criteria to define boundary conditions are proposed to overcome the dissimilar anatomical definition delivered by both modalities. The strategy to define boundary conditions is novel in the present context, and naturally accounts for the flow redistribution induced by the resistance of coronary vessels...
January 25, 2017: Journal of Biomechanics
https://www.readbyqxmd.com/read/27934610/in-vivo-validation-of-mathematically-derived-fractional-flow-reserve-for-assessing-haemodynamics-of-coronary-tandem-lesions
#19
Jihoon Kweon, Young-Hak Kim, Dong Hyun Yang, June-Goo Lee, Jae-Hyung Roh, Gary S Mintz, Seung-Whan Lee, Seong-Wook Park
AIMS: Our aim was to propose a prediction model for the post-stenting fractional flow reserve (FFR'd,pred) at a position distal to the tandem lesion. METHODS AND RESULTS: Using the FFR at a position proximal to the tandem lesion (FFRp), and the FFR gradients across proximal (ΔFFRp) and distal (ΔFFRd) stenoses, FFR'd,pred after treating either the distal or proximal lesion was predicted as FFRp-ΔFFRp/(1-1.33kΔFFRd) or FFRp-ΔFFRd/(1-1.33ΔFFRp), respectively...
December 10, 2016: EuroIntervention
https://www.readbyqxmd.com/read/27914491/impact-of-lesion-characteristics-on-the-prediction-of-optimal-poststent-fractional-flow-reserve
#20
Hirohiko Ando, Hiroaki Takashima, Akihiro Suzuki, Shinichiro Sakurai, Soichiro Kumagai, Akiyoshi Kurita, Katsuhisa Waseda, Tetsuya Amano
BACKGROUND: Poststent fractional flow reserve (FFR) is a useful indicator of optimal percutaneous coronary intervention, and higher poststent FFR is associated with favorable long-term clinical outcome. However, little is known about the factors influencing poststent FFR. The purpose of this study was to determine the impact of lesion characteristics on poststent FFR. METHODS: For patients who had scheduled stent implantation for stable angina, FFR measurements at maximum hyperemia were performed before and after coronary stent implantation...
December 2016: American Heart Journal
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