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https://www.readbyqxmd.com/read/28809723/nitroglycerin-derived-pd-pa-for-the-assessment-of-intermediate-coronary-lesions
#1
Zeev Israeli, Rodrigo Bagur, Dorian Murariu, Sabrina Wall, Mistre Alemayehu, Yasir Parviz, Pantelis Diamantouros, Shahar Lavi
OBJECTIVES: To assess the predictive value of Pd/Pa after nitroglycerin administration (Pd/Pa[N]) as compared with standard fractional flow reserve (FFR). METHODS: Consecutive patients with intermediate coronary lesions assessed by FFR between January 2014 and October 2015 were included. We measured Pd/Pa at baseline, Pd/Pa(N), and Pd/Pa after incremental doses of intracoronary adenosine. RESULTS: A total of 134 patients (27% females; mean age, 65 years) were included...
August 15, 2017: Journal of Invasive Cardiology
https://www.readbyqxmd.com/read/28798781/association-of-coronary-ischemia-estimated-by-fractional-flow-reserve-and-psychological-characteristics-of-patients
#2
Miodrag Jovan Sreckovic, Nikola Jagic, Vladimir Miloradovic, Aleksandar Neskovic, Ivan Soldatovic, Ilija Srdanovic
INTRODUCTION: Psychological characteristics of patients, depression, stress and anxiety are recognized as important confounding risk factors for ischemic heart disease. However, the impact of psychological characteristics on coronary ischemia and vice versa remain poorly understood. AIM: To demonstrate the interplay of psychological characteristics, depression, stress and anxiety with coronary ischemia estimated with fractional flow reserve (FFR). MATERIAL AND METHODS: From 2014 to 2016, 147 patients who were planned for FFR measurement were included in this study...
2017: Postępy W Kardiologii Interwencyjnej, Advances in Interventional Cardiology
https://www.readbyqxmd.com/read/28790165/prognostic-value-of-fractional-flow-reserve-measured-immediately-after-drug-eluting-stent-implantation
#3
Zsolt Piroth, Gabor G Toth, Pim A L Tonino, Emanuele Barbato, Soheila Aghlmandi, Nick Curzen, Gilles Rioufol, Nico H J Pijls, William F Fearon, Peter Jüni, Bernard De Bruyne
BACKGROUND: The predictive value of fractional flow reserve (FFR) measured immediately after percutaneous coronary intervention (PCI) with drug-eluting stent placement has not been prospectively investigated. We investigated the potential of post-PCI FFR measurements to predict clinical outcome in patients from FAME 1 and 2 trials (Fractional Flow Reserve or Angiography for Multivessel Evaluation). METHODS AND RESULTS: All patients of FAME 1 and FAME 2 who had post-PCI FFR measurement were included...
August 2017: Circulation. Cardiovascular Interventions
https://www.readbyqxmd.com/read/28789941/effect-of-the-ratio-of-coronary-arterial-lumen-volume-to-left-ventricle-myocardial-mass-derived-from-coronary-ct-angiography-on-fractional-flow-reserve
#4
Charles A Taylor, Sara Gaur, Jonathon Leipsic, Stephan Achenbach, Daniel S Berman, Jesper M Jensen, Damini Dey, Hans Erik Bøtker, Hyun Jin Kim, Sophie Khem, Alan Wilk, Christopher K Zarins, Hiram Bezerra, John Lesser, Brian Ko, Jagat Narula, Amir Ahmadi, Kristian A Øvrehus, Fred St Goar, Bernard De Bruyne, Bjarne L Nørgaard
BACKGROUND: We hypothesize that in patients with suspected coronary artery disease (CAD), lower values of the ratio of total epicardial coronary arterial lumen volume to left ventricular myocardial mass (V/M) result in lower fractional flow reserve (FFR). METHODS: V/M was computed in 238 patients from the NXT trial who underwent coronary computed tomography angiography (CTA), quantitative coronary angiography (QCA) and FFR measurement in 438 vessels. Nitroglycerin was administered prior to CT, QCA and FFR acquisition...
August 3, 2017: Journal of Cardiovascular Computed Tomography
https://www.readbyqxmd.com/read/28766832/the-relationship-between-the-basal-coronary-translesional-pressure-gradient-and-fractional-flow-reserve
#5
William M Wilson, Anoop S V Shah, Duncan Birse, Emma Harley, David B Northridge, Neal G Uren
AIM: Fractional flow reserve (FFR) allows for physiological definition of coronary lesion severity but requires induction of maximal coronary circulation hyperemia with administration of adenosine leading to coronary resistive vessel vasodilatation. However, the hyperemic response to adenosine, and therefore the calculation of FFR, may be affected by dysfunction of the coronary microvasculature. The aim was to define the relationship between basal Pd /Pa and FFR and identify lesion-independent predictors of the change in Pd /Pa with hyperemia...
August 2, 2017: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/28763291/manikin-based-size-resolved-penetrations-of-ce-marked-filtering-facepiece-respirators
#6
Norbert Serfozo, Jakub Ondráček, Petr Otáhal, Mihalis Lazaridis, Vladimír Ždímal
The purpose of this manikin-based study was to determine the percentage penetrations of 9 CE-marked filtering facepiece respirator models (2 sample from each) from filtering classes FFP1, FFP2, and FFP3 and to demonstrate by an independent measurement method the disadvantages and shortcomings of the currently valid European Norm (EN 149:2001) for filtering facepieces. All of the filtering facepieces were evaluated size-selectively in an experimental chamber using charge-neutralized monodisperse ammonium sulfate in 9 sizes ranging from 20 to 400 nm of count median diameter (CMD) under flowrate of 95 L/min...
August 1, 2017: Journal of Occupational and Environmental Hygiene
https://www.readbyqxmd.com/read/28754566/impact-of-asymmetric-dimethylarginine-on-coronary-physiology-early-after-heart-transplantation
#7
Rushi V Parikh, Kiran K Khush, Helen Luikart, Vedant S Pargaonkar, Yuhei Kobayashi, Jang Hoon Lee, Seema Sinha, Garrett Cohen, Hannah A Valantine, Alan C Yeung, William F Fearon
Cardiac allograft vasculopathy is a major cause of long-term graft failure following heart transplantation. Asymmetric dimethylarginine (ADMA), a marker of endothelial dysfunction, has been mechanistically implicated in the development of cardiac allograft vasculopathy, but its impact on coronary physiology early after transplantation is unknown. Invasive indices of coronary physiology, namely, fractional flow reserve (FFR), the index of microcirculatory resistance, and coronary flow reserve, were measured with a coronary pressure wire in the left anterior descending artery within 8 weeks (baseline) and 1 year after transplant...
June 29, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/28742827/the-relationship-between-coronary-artery-distensibility-and-fractional-flow-reserve
#8
Andy S C Yong, Ashkan Javadzadegan, William F Fearon, Abouzar Moshfegh, Jerrett K Lau, Stephen Nicholls, Martin K C Ng, Leonard Kritharides
Discordance between angiography-based anatomical assessment of coronary stenosis severity and fractional flow reserve (FFR) has been attributed to several factors including lesion length and irregularity, and the myocardial territory supplied by the target vessel. We sought to examine if coronary arterial distensibility is an independent contributor to this discordance. There were two parts to this study. The first consisted of "in silico" models of 26 human coronary arteries. Computational fluid dynamics-derived FFR was calculated for fully rigid, partially distensible and fully distensible models of the 26 arteries...
2017: PloS One
https://www.readbyqxmd.com/read/28736204/neural-stability-a-reflection-of-automaticity-in-reading
#9
Silvia Siu-Yin Lam, Travis White-Schwoch, Steven G Zecker, Jane Hornickel, Nina Kraus
Automaticity, the ability to perform a task rapidly with minimal effort, plays a key role in reading fluency and is indexed by rapid automatized naming (RAN) and processing speed. Yet little is known about automaticity's neurophysiologic underpinnings. The more efficiently sound is encoded, the more automatic sound processing can be. In turn, this automaticity could free up cognitive resources such as attention and working memory to help build an integrative reading network. Therefore, we hypothesized that automaticity and reading fluency correlate with stable neural representation of sounds, given a larger body of literature suggesting the close relationship between neural stability and the integrative function in the central auditory system...
July 21, 2017: Neuropsychologia
https://www.readbyqxmd.com/read/28728652/accuracy-of-fractional-flow-reserve-measurements-in-clinical-practice-observations-from-a-core-laboratory-analysis
#10
Mitsuaki Matsumura, Nils P Johnson, William F Fearon, Gary S Mintz, Gregg W Stone, Keith G Oldroyd, Bernard De Bruyne, Nico H J Pijls, Akiko Maehara, Allen Jeremias
OBJECTIVES: The aim of this study was to compare site-reported measurements of fractional flow reserve (FFR) with FFR analysis by an independent core laboratory (CL). BACKGROUND: FFR is an index of coronary stenosis severity that has been validated in multiple trials and is widely used in clinical practice. However, the incidence of suboptimal FFR measurements is unknown. METHODS: Patients undergoing FFR assessment within the CONTRAST (Can Contrast Injection Better Approximate FFR Compared to Pure Resting Physiology) study had paired, repeated measurements of multiple physiological metrics per local practice...
July 24, 2017: JACC. Cardiovascular Interventions
https://www.readbyqxmd.com/read/28674929/frequency-of-a-large-drift-caused-by-pressure-wire-using-optical-fibers
#11
Yoshiaki Kawase, Toru Tanigaki, Akihiro Hirakawa, Hiroyuki Omori, Tetsuo Hirata, Syuuichi Okamoto, Hideaki Ota, Jun Kikuchi, Munenori Okubo, Hiroki Kamiya, Masanori Kawasaki, Takahiko Suzuki, Hitoshi Matsuo
The frequency of a large pressure signal drift (PDs) caused by pressure wire using optical fibers and its effect on fractional flow reserve (FFR)-based decision-making is not clear. We used pressure wires using optical fibers as "workhorse wires" for 95 consecutive lesions. The wire was normalized at the tip of the guiding catheter just before performing the percutaneous coronary intervention (PCI) and was used without re-normalization until the end of the PCI. The drift value at the end of the procedures was evaluated...
July 3, 2017: Cardiovascular Intervention and Therapeutics
https://www.readbyqxmd.com/read/28666784/interpreting-results-of-coronary-computed-tomography-angiography-derived-fractional-flow-reserve-in-clinical-practice
#12
REVIEW
Mark G Rabbat, Daniel S Berman, Morton Kern, Gilbert Raff, Kavitha Chinnaiyan, Lynne Koweek, Leslee J Shaw, Philipp Blanke, Markus Scherer, Jesper M Jensen, John Lesser, Bjarne L Nørgaard, Gianluca Pontone, Bernard De Bruyne, Jeroen J Bax, Jonathon Leipsic
The application of computational fluid dynamics to coronary computed tomography angiography allows Fractional Flow Reserve (FFR) to be calculated non-invasively (FFRCT), enabling computation of FFR from coronary computed tomography angiography acquired at rest both for individual lesions as well as along the entire course of a coronary artery. FFRCT, validated in a number of accuracy studies and a large clinical utility trial, is beginning to penetrate clinical practice. Importantly, while accuracy trials compared FFRCT to invasively measured FFR at a single point in the coronary tree, clinical reports of FFRCT provide information regarding a patient's entire coronary vasculature...
June 23, 2017: Journal of Cardiovascular Computed Tomography
https://www.readbyqxmd.com/read/28651849/meta-analysis-of-head-to-head-comparison-of-intracoronary-versus-intravenous-adenosine-for-the-assessment-of-fractional-flow-reserve
#13
Stefano Rigattieri, Giuseppe Biondi Zoccai, Alessandro Sciahbasi, Cristian Di Russo, Maria Cera, Roberto Patrizi, Silvio Fedele, Andrea Berni, Francesco Rocco Pugliese
Intravenous (IV) infusion of adenosine represents the gold standard for measuring fractional flow reserve (FFR). However, IV adenosine is more expensive and time-consuming compared with intracoronary (IC) boluses of adenosine. We conducted a meta-analysis of studies comparing IC with IV adenosine for FFR assessment in the same coronary lesions. We searched for studies comparing IC with IV adenosine and reporting absolute FFR values or rate of abnormal FFR for both routes. Prespecified subgroup analysis was performed to appraise studies using low-dose (<100 μg) or high-dose IC adenosine (≥100 μg)...
May 30, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/28651585/a-vessel-length-based-method-to-compute-coronary-fractional-flow-reserve-from-optical-coherence-tomography-images
#14
Kyung Eun Lee, Seo Ho Lee, Eun-Seok Shin, Eun Bo Shim
BACKGROUND: Hemodynamic simulation for quantifying fractional flow reserve (FFR) is often performed in a patient-specific geometry of coronary arteries reconstructed from the images from various imaging modalities. Because optical coherence tomography (OCT) images can provide more precise vascular lumen geometry, regardless of stenotic severity, hemodynamic simulation based on OCT images may be effective. The aim of this study is to perform OCT-FFR simulations by coupling a 3D CFD model from geometrically correct OCT images with a LPM based on vessel lengths extracted from CAG data with clinical validations for the present method...
June 26, 2017: Biomedical Engineering Online
https://www.readbyqxmd.com/read/28649949/diagnostic-performance-of-a-lattice-boltzmann-based-method-for-fast-ct-fractional-flow-reserve
#15
Andreas Giannopoulos, Anji Tang, Yin Ge, Michael Cheezum, Michael Steigner, Shinichiro Fujimoto, Kanako Kumamaru, Dante Chiappino, Daniele Della Latta, Sergio Berti, Sara Chiappino, Frank Rybicki, Simone Melchionna, Dimitrios Mitsouras
AIMS: Fractional flow reserve (FFR) estimated from coronary computed tomography angiography (CT-FFR) offers non-invasive detection of lesion-specific ischemia. We developed and validated a fast CT-FFR algorithm utilizing the Lattice-Boltzmann Method for blood flow simulation (LBM CT-FFR). METHODS AND RESULTS: 64 patients from 3 institutions with clinically-indicated CTA and invasive FFR measurement were retrospectively analyzed. CT-FFR was performed using an on-site tool interfacing with a commercial Lattice-Boltzmann fluid dynamics cloud-based platform...
June 27, 2017: EuroIntervention
https://www.readbyqxmd.com/read/28649159/initial-simulated-ffr-investigation-using-flow-measurements-in-patient-specific-3d-printed-coronary-phantoms
#16
Lauren Shepard, Kelsey Sommer, Richard Izzo, Alexander Podgorsak, Michael Wilson, Zaid Said, Frank J Rybicki, Dimitrios Mitsouras, Stephen Rudin, Erin Angel, Ciprian N Ionita
PURPOSE: Accurate patient-specific phantoms for device testing or endovascular treatment planning can be 3D printed. We expand the applicability of this approach for cardiovascular disease, in particular, for CT-geometry derived benchtop measurements of Fractional Flow Reserve, the reference standard for determination of significant individual coronary artery atherosclerotic lesions. MATERIALS AND METHODS: Coronary CT Angiography (CTA) images during a single heartbeat were acquired with a 320×0...
February 11, 2017: Proceedings of SPIE
https://www.readbyqxmd.com/read/28644727/impact-of-time-and-assisted-donning-on-respirator-fit
#17
Brian Rembialkowski, Margaret Sietsema, Lisa Brosseau
The goal of this study was to examine the impact of assistance with donning and time on quantitative fit factors (FF) and pass rates for subjects wearing an N95 filtering facepiece respirator (FFR) and a non-certified adhesive mask. Fit factors were measured using two side-by-side TSI Portacount instruments sampling second-by-second simultaneous inside- and outside-facepiece concentrations. Naïve subjects made two visits at least one week apart. At each visit subjects first donned either the respirator or adhesive mask without assistance and performed a five-exercise fast fit test...
June 23, 2017: Journal of Occupational and Environmental Hygiene
https://www.readbyqxmd.com/read/28642995/accuracy-and-reproducibility-of-fast-fractional-flow-reserve-computation-from-invasive-coronary-angiography
#18
A R van Rosendael, G Koning, A C Dimitriu-Leen, J M Smit, J M Montero-Cabezas, F van der Kley, J W Jukema, J H C Reiber, J J Bax, A J H A Scholte
Fractional flow reserve (FFR) guided percutaneous coronary intervention (PCI) is associated with favourable outcome compared with revascularization based on angiographic stenosis severity alone. The feasibility of the new image-based quantitative flow ratio (QFR) assessed from 3D quantitative coronary angiography (QCA) and thrombolysis in myocardial infarction (TIMI) frame count using three different flow models has been reported recently. The aim of the current study was to assess the accuracy, and in particular, the reproducibility of these three QFR techniques when compared with invasive FFR...
September 2017: International Journal of Cardiovascular Imaging
https://www.readbyqxmd.com/read/28612908/association-between-fractional-flow-reserve-and-duke-treadmill-score-in-patients-with-single-vessel-disease
#19
Süleyman Kalaycı, Belma Kalaycı, Ekrem Şahan, Asiye Ayça Ayyılmaz Boyacı
BACKGROUND: Duke Treadmill score (DTS) is an index that provides prognostic information calculated at exercise stress test (EST). Fractional flow reserve (FFR) is an invasive method used to evaluate intermediate coronary stenosis. The direct relation of DTS and FFR has not been studied to date. AIM: The present study aims to investigate the relationship between the Duke Treadmill score (DTS) and fractional flow reserve (FFR). METHODS: The study population consisted of a total of 106 patients who have single-vessel disease, as confirmed by the coronary angiography (CAG), performed following EST, and whose FFRs have been measured...
June 14, 2017: Kardiologia Polska
https://www.readbyqxmd.com/read/28612008/hybrid-instantaneous-wave-free-ratio-fractional-flow-reserve-versus-fractional-flow-reserve-in-the-real-world
#20
Kara Shuttleworth, Kristina Smith, Jonathan Watt, Jamie A L Smith, Stephen J Leslie
BACKGROUND: The instantaneous wave-free ratio (iFR) is a novel method to assess the ischemic potential of coronary artery stenoses. Clinical trial data have shown that iFR has acceptable diagnostic agreement with fractional flow reserve (FFR), the reference standard for the functional assessment of coronary stenoses. This study compares iFR measurements with FFR measurements in a real world, single-center setting. METHODS AND RESULTS: Instantaneous wave-free ratio and FFR were measured in 50 coronary artery lesions in 42 patients, with FFR ≤ 0...
2017: Frontiers in Cardiovascular Medicine
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