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https://www.readbyqxmd.com/read/27900990/prognostic-value-of-gai-s-plaque-score-and-agatston-coronary-artery-calcium-score-for-functionally-significant-coronary-artery-stenosis
#1
Chuang Zhang, Shuang Yang, Lu-Yue Gai, Zhi-Qi Han, Qian Xin, Xiao-Bo Yang, Jun-Jie Yang, Qin-Hua Jin
BACKGROUND: The prognostic values of the coronary computed tomography angiography (CCTA) score for predicting future cardiovascular events have been previously demonstrated in numerous studies. However, few studies have used the rich information available from CCTA to detect functionally significant coronary lesions. We sought to compare the prognostic values of Gai's plaque score and the coronary artery calcium score (CACS) of CCTA for predicting functionally significant coronary lesions, using fractional flow reserve (FFR) as the gold standard...
2016: Chinese Medical Journal
https://www.readbyqxmd.com/read/27892882/clinical-and-angiographic-predictors-of-persistently-ischemic-fractional-flow-reserve-after-percutaneous-revascularization
#2
Shiv Kumar Agarwal, Srikanth Kasula, Ahmed Almomani, Yalcin Hacioglu, Zubair Ahmed, Barry F Uretsky, Abdul Hakeem
AIMS: Despite optimal angiographic results after percutaneous coronary intervention (PCI), some lesions may continue to produce ischemia under maximal hyperemia. We evaluated the factors associated with persistently ischemic fractional flow reserve (FFR) after angiographically successful PCI. METHODS AND RESULTS: A total of 574 consecutive patients with 664 lesions undergoing PCI who had FFR pre- and post-PCI were analyzed. Percutaneous coronary intervention led to effective ischemia reduction from pre-FFR (0...
October 29, 2016: American Heart Journal
https://www.readbyqxmd.com/read/27876181/analysis-of-suboptimal-stent-deployment-using-intravascular-ultrasound-and-coronary-pressure-pullback-measurement
#3
Nobuhiro Tanaka, Nico H J Pijls, Jun Yamashita, Yo Kimura, Masashi Ogawa, Naotaka Murata, Kunihiro Sakoda, Kou Hoshino, Youhei Hokama, Akira Yamashina
BACKGROUND: There are some cases in whom a sufficient improvement in fractional flow reserve (FFR) could not be achieved even if anatomical results indicated satisfactory stent deployment. We investigated the relation of abnormal findings between intravascular ultrasound (IVUS) and coronary pressure pullback measurement (CP-PB). METHODS: IVUS and CP-PB were investigated after stent deployment in 60 vessels in 53 patients. CP-PB criterion for adequate stent deployment was defined as a ratio of coronary pressure at the stent distal edge to the proximal edge (Psd/Psp) that is greater than 0...
November 18, 2016: Journal of Cardiology
https://www.readbyqxmd.com/read/27872119/efficacy-of-intravenous-nicorandil-for-fractional-flow-reserve-assessment-study-protocol-for-a-crossover-randomised-trial
#4
Takeshi Nishi, Hideki Kitahara, Yoshihide Fujimoto, Takashi Nakayama, Kazumasa Sugimoto, Kengo Nagashima, Hideki Hanaoka, Yoshio Kobayashi
INTRODUCTION: Nicorandil has vasodilatory effects on both the epicardial coronary arteries and the coronary microvasculature, thereby increasing coronary blood flow. Intravenous administration of nicorandil can be applicable for fractional flow reserve (FFR) measurement as a hyperaemic agent and a possible alternative to adenosine. However, the effectiveness of intravenous nicorandil infusion for FFR measurement is largely unclear. METHODS AND ANALYSIS: This crossover randomised study is being performed to investigate the efficacy of intravenous administration of nicorandil for FFR measurement...
November 21, 2016: BMJ Open
https://www.readbyqxmd.com/read/27867288/visual-functional-mismatch-between-coronary-angiography-fractional-flow-reserve-and-quantitative-coronary-angiography
#5
Morteza Safi, Vahid Eslami, Mohammad Hasan Namazi, Hossain Vakili, Habib Saadat, Saeid Alipourparsa, Ali Adibi, Mohammad Reza Movahed
Anatomical and functional mismatches are not uncommon in the assessment of coronary lesions. The aim of this study was to identify clinical and lesion-specific factors affecting angiographic, anatomical, and functional mismatch in intermediate coronary lesions. In patients who underwent coronary angiography for clinical reasons, fractional flow reserve (FFR), and quantitative coronary angiography (QCA) analyses for intermediate stenotic lesions were performed simultaneously. Mismatches between the measured values were analyzed...
December 2016: International Journal of Angiology: Official Publication of the International College of Angiology, Inc
https://www.readbyqxmd.com/read/27867139/in-vivo-validation-of-mathematically-derived-fractional-flow-reserve-for-assessing-hemodynamics-of-coronary-tandem-lesions
#6
Jihoon Kweon, Young-Hak Kim, Dong Hyun Yang, June-Goo Lee, Jae-Hyung Roh, Gary S Mintz, Seung-Whan Lee, Seong-Wook Park
AIMS: To propose a prediction model for the post-stenting fractional flow reserve (FFR'd,pred) at a position distal to the tandem lesion. METHODS AND RESULTS: Using the FFR at a position proximal to the tandem lesion (FFRp), the FFR gradients across proximal (ΔFFRp) and distal (ΔFFRd) stenoses, FFR'd,pred after treating either the distal or proximal lesion was predicted as FFRp-ΔFFRp/(1-1.33kΔFFRd) or FFRp- ΔFFRd/(1-1.33ΔFFRp), respectively. The flow fraction of the distal main branch (k) was estimated using the diameter ratio of side to distal main branches...
November 22, 2016: EuroIntervention
https://www.readbyqxmd.com/read/27866677/pressure-drop-and-arterial-compliance-two-arterial-parameters-in-one-measurement
#7
Oren M Rotman, Uri Zaretsky, Avraham Shitzer, Shmuel Einav
Coronary artery pressure-drop and distensibility (compliance) are two major, seemingly unrelated, parameters in the cardiovascular clinical setting, which are indicative of coronary arteries patency and atherosclerosis severity. While pressure drop is related to flow, and therefore serves as a functional indicator of a stenosis severity, the arterial distensibility is indicative of the arterial stiffness, and hence the arterial wall composition. In the present study, we hypothesized that local pressure drops are dependent on the arterial distensibility, and hence can provide information on both indices...
November 12, 2016: Journal of Biomechanics
https://www.readbyqxmd.com/read/27866538/-respiratory-protection-provided-by-n95-filtering-facepiece-respirators-and-disposable-medicine-masks-against-airborne-bacteria-in-different-working-environments
#8
W Lu, X C Zhu, X Y Zhang, Y T Chen, W H Chen
Objective: To determine the relative protection provided by N95 filtering facepiece respirators (FFR) and disposable medicine masks (DMM) against airborne bacteria in different working environments. Methods: The field study was performed with 12 subjects wearing an N95 filtering facepiece respirator and a disposable medicine mask for 1h, respectively. Airborne microorganisms and bacteria samples from both the external (Ce) and the inner (Ci) surface of N95 FFR and DMM are collected. The Ce: Ci ratio was used to calculate the bacterial filtering proportion...
September 20, 2016: Chinese Journal of Industrial Hygiene and Occupational Diseases
https://www.readbyqxmd.com/read/27834663/discordance-between-resting-and-hyperemic-indices-of-coronary-stenosis-severity-the-verify-2-study-a-comparative-study-of-resting-coronary-pressure-gradient-instantaneous-wave-free-ratio-and-fractional-flow-reserve-in-an-unselected-population-referred-for-invasive
#9
Barry Hennigan, Keith G Oldroyd, Colin Berry, Nils Johnson, John McClure, Peter McCartney, Margaret B McEntegart, Hany Eteiba, Mark C Petrie, Paul Rocchiccioli, Richard Good, Martin M Lindsay, Stuart Hood, Stuart Watkins
BACKGROUND: Distal coronary to aortic pressure ratio (Pd/Pa) and instantaneous wave-free ratio (iFR) are indices of functional significance of a coronary stenosis measured without hyperemia. It has been suggested that iFR has superior diagnostic accuracy to Pd/Pa when compared with fractional flow reserve (FFR).We hypothesized that in comparison with FFR, revascularization decisions based on either binary cutoff values for iFR and Pd/Pa or hybrid strategies incorporating iFR or Pd/Pa will result in similar levels of disagreement...
November 2016: Circulation. Cardiovascular Interventions
https://www.readbyqxmd.com/read/27816499/effects-of-noise-exposure-on-young-adults-with-normal-audiograms-i-electrophysiology
#10
Garreth Prendergast, Hannah Guest, Kevin J Munro, Karolina Kluk, Agnès Léger, Deborah A Hall, Michael G Heinz, Christopher J Plack
Noise-induced cochlear synaptopathy has been demonstrated in numerous rodent studies. In these animal models, the disorder is characterized by a reduction in amplitude of wave I of the auditory brainstem response (ABR) to high-level stimuli, whereas the response at threshold is unaffected. The aim of the present study was to determine if this disorder is prevalent in young adult humans with normal audiometric hearing. One hundred and twenty six participants (75 females) aged 18-36 were tested. Participants had a wide range of lifetime noise exposures as estimated by a structured interview...
November 2, 2016: Hearing Research
https://www.readbyqxmd.com/read/27766423/the-assessment-of-ischaemic-burden-validation-of-a-functional-jeopardy-score-against-cardiovascular-magnetic-resonance-perfusion-imaging
#11
Shazia T Hussain, Geraint Morton, Kalpa De Silva, Roy Jogiya, Andreas Schuster, Matthias Paul, Divaka Perera, Eike Nagel
AIMS: This study assesses the relationship between classical anatomical jeopardy scores, functional jeopardy scores (combined anatomical and haemodynamic data), and the extent of ischaemia identified on cardiovascular magnetic resonance (CMR) perfusion imaging. METHODS AND RESULTS: In 42 patients with stable angina and suspected coronary artery disease (CAD), CMR perfusion imaging was performed. Fractional Flow Reserve (FFR) was measured in vessels with ≥50 % stenosis...
October 20, 2016: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
https://www.readbyqxmd.com/read/27754754/sex-differences-in-fractional-flow-reserve-guided-revascularization-a-nationwide-analysis
#12
Vladimir Lakhter, Mohamad Alkhouli, Chad J Zack, Huaqing Zhao, Howard A Cohen, Brian P O'Neill, Brian O'Murchu, Alfred A Bove, Riyaz Bashir
BACKGROUND: Women with coronary artery disease are less likely to be revascularized than men based on angiography alone. Recent studies have shown that female patients have higher fractional flow reserve (FFR) values for a given severity of coronary stenosis. However, gender differences in coronary revascularization rates following FFR assessment are unknown. METHODS: The nationwide inpatient sample database was used to identify all patients who underwent FFR in the United States between January 2009 and December 2010...
October 18, 2016: Journal of Women's Health
https://www.readbyqxmd.com/read/27718139/feasibility-and-diagnostic-performance-of-fractional-flow-reserve-measurement-derived-from-coronary-computed-tomography-angiography-in-real-clinical-practice
#13
Tetsuma Kawaji, Hiroki Shiomi, Hiroshi Morishita, Takeshi Morimoto, Charles A Taylor, Shotaro Kanao, Koji Koizumi, Satoshi Kozawa, Kazuhisa Morihiro, Hirotoshi Watanabe, Junichi Tazaki, Masao Imai, Naritatsu Saito, Satoshi Shizuta, Koh Ono, Kaori Togashi, Takeshi Kimura
Non-invasive fractional flow reserve measured by coronary computed tomography angiography (FFRCT) has demonstrated a high diagnostic accuracy for detecting coronary artery disease (CAD) in selected patients in prior clinical trials. However, feasibility of FFRCT in unselected population have not been fully evaluated. Among 60 consecutive patients who had suspected significant CAD by coronary computed tomography angiography (CCTA) and were planned to undergo invasive coronary angiography, 48 patients were enrolled in this study comparing FFRCT with invasive fractional flow reserve (FFR) without any exclusion criteria for the quality of CCTA image...
October 7, 2016: International Journal of Cardiovascular Imaging
https://www.readbyqxmd.com/read/27717991/-bifurcation-lesions-how-should-they-be-assessed-and-treated
#14
H M Nef, O Dörr, H Möllmann, A Elsässer
Bifurcation lesions are a therapeutic challenge in the interventional treatment of coronary artery disease. Thus, consideration of anatomical aspects and selection of the most appropriate strategy for an individual bifurcation have an impact on the interventional outcome. Accordingly, assessment of the type of bifurcation stenosis, including the relevance of the side branches, vessel diameter and the angle between the two branches are critical for the optimal choice of interventional strategy. The fractional flow reserve (FFR) is a parameter that provides a measure of the severity of coronary stenosis and despite some limitations, FFR can be applied to bifurcation lesions...
October 7, 2016: Herz
https://www.readbyqxmd.com/read/27716131/rationale-and-design-of-the-credence-trial-computed-tomographic-evaluation-of-atherosclerotic-determinants-of-myocardial-ischemia
#15
Asim Rizvi, Bríain Ó Hartaigh, Paul Knaapen, Jonathon Leipsic, Leslee J Shaw, Daniele Andreini, Gianluca Pontone, Subha Raman, Muhammad Akram Khan, Michael Ridner, Faisal Nabi, Alessia Gimelli, James Jang, Jason Cole, Ryo Nakazato, Christopher Zarins, Donghee Han, Ji Hyun Lee, Jackie Szymonifika, Millie J Gomez, Quynh A Truong, Hyuk-Jae Chang, Fay Y Lin, James K Min
BACKGROUND: Coronary computed tomography angiography (CCTA) allows for non-invasive assessment of obstructive coronary artery disease (CAD) beyond measures of stenosis severity alone. This assessment includes atherosclerotic plaque characteristics (APCs) and calculation of fractional flow reserve (FFR) from CCTA (FFRCT). Similarly, stress imaging by myocardial perfusion scintigraphy (MPS) provides vital information. To date, the diagnostic performance of integrated CCTA assessment versus integrated MPS assessment for diagnosis of vessel-specific ischemia remains underexplored...
October 6, 2016: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/27712739/diagnostic-accuracy-of-fast-computational-approaches-to-derive%C3%A2-fractional-flow-reserve-from%C3%A2-diagnostic-coronary-angiography-the-international-multicenter-favor-pilot-study
#16
Shengxian Tu, Jelmer Westra, Junqing Yang, Clemens von Birgelen, Angela Ferrara, Mariano Pellicano, Holger Nef, Matteo Tebaldi, Yoshinobu Murasato, Alexandra Lansky, Emanuele Barbato, Liefke C van der Heijden, Johan H C Reiber, Niels R Holm, William Wijns
OBJECTIVES: The aim of this prospective multicenter study was to identify the optimal approach for simple and fast fractional flow reserve (FFR) computation from radiographic coronary angiography, called quantitative flow ratio (QFR). BACKGROUND: A novel, rapid computation of QFR pullbacks from 3-dimensional quantitative coronary angiography was developed recently. METHODS: QFR was derived from 3 flow models with: 1) fixed empiric hyperemic flow velocity (fixed-flow QFR [fQFR]); 2) modeled hyperemic flow velocity derived from angiography without drug-induced hyperemia (contrast-flow QFR [cQFR]); and 3) measured hyperemic flow velocity derived from angiography during adenosine-induced hyperemia (adenosine-flow QFR [aQFR])...
October 10, 2016: JACC. Cardiovascular Interventions
https://www.readbyqxmd.com/read/27704198/diagnostic-value-of-transmural-perfusion-ratio-derived-from-dynamic-ct-based-myocardial-perfusion-imaging-for-the-detection-of-haemodynamically-relevant-coronary-artery-stenosis
#17
Adriaan Coenen, Marisa M Lubbers, Akira Kurata, Atsushi Kono, Admir Dedic, Raluca G Chelu, Marcel L Dijkshoorn, Alexia Rossi, Robert-Jan M van Geuns, Koen Nieman
OBJECTIVES: To investigate the additional value of transmural perfusion ratio (TPR) in dynamic CT myocardial perfusion imaging for detection of haemodynamically significant coronary artery disease compared with fractional flow reserve (FFR). METHODS: Subjects with suspected or known coronary artery disease were prospectively included and underwent a CT-MPI examination. From the CT-MPI time-point data absolute myocardial blood flow (MBF) values were temporally resolved using a hybrid deconvolution model...
October 4, 2016: European Radiology
https://www.readbyqxmd.com/read/27692748/-measurement-of-fractional-flow-reserve-in-patients-with-severe-aortic-stenosis-a-valid-test
#18
J Kikoïne, M Lebon, G Gouffran, D Millischer, S Cattan, O Nallet
A 54-year-old woman was hospitalized for an acute pulmonary oedema revealing a severe aortic stenosis (AS) associated with an aortic aneurysm and a left ventricular hypertrophy (LVH). The coronary angiography found an equivocal left main lesion. Fractional flow reserve (FFR) showed hemodynamic significance (FFR=0.78) and optical coherence tomography confirmed this result with a minimal lumen area of 4.9mm(2). FFR-guided percutaneous intervention is reported to improve outcome in patients with stable coronary disease...
September 28, 2016: Annales de Cardiologie et D'angéiologie
https://www.readbyqxmd.com/read/27676311/filter-penetration-and-breathing-resistance-evaluation-of-respirators-and-dust-masks
#19
Joel Ramirez, Patrick O'Shaughnessy
The primary objective of this study was to compare the filter performance of a representative selection of uncertified dust masks relative to the filter performance of a set of NIOSH-approved N95 filtering face-piece respirators (FFRs). Five different models of commercially available dust masks were selected for this study. Filter penetration of new dust masks was evaluated against a sodium chloride aerosol. Breathing resistance (BR) of new dust masks and FFRs was then measured for 120 min while challenging the dust masks and FFRs with Arizona road dust (ARD) at 25°C and 30% relative humidity...
September 27, 2016: Journal of Occupational and Environmental Hygiene
https://www.readbyqxmd.com/read/27639627/comparison-of-coronary-computed-tomography-angiography-derived-vs-invasive-fractional-flow-reserve-assessment-meta-analysis-with-subgroup-evaluation-of-intermediate-stenosis
#20
Stefan Baumann, Matthias Renker, Svetlana Hetjens, Stephen R Fuller, Tobias Becher, Dirk Loßnitzer, Ralf Lehmann, Ibrahim Akin, Martin Borggrefe, Siegfried Lang, Julian L Wichmann, U Joseph Schoepf
RATIONALE AND OBJECTIVES: Invasive coronary angiography (ICA) with fractional flow reserve (FFR) assessment is the reference standard for the detection of hemodynamically relevant coronary lesions. We have investigated whether coronary computed tomography angiography (cCTA)-derived FFR (fractional flow reserve from coronary computed tomographic angiography [CT-FFR]) measurement improves diagnostic accuracy over cCTA. METHODS AND RESULTS: A literature search was performed for studies comparing invasive FFR, cCTA, and CT-FFR...
September 14, 2016: Academic Radiology
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