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Ffr measurement

Shazia T Hussain, Geraint Morton, Kalpa De Silva, Roy Jogiya, Andreas Schuster, Matthias Paul, Divaka Perera, Eike Nagel
AIMS: This study assesses the relationship between classical anatomical jeopardy scores, functional jeopardy scores (combined anatomical and haemodynamic data), and the extent of ischaemia identified on cardiovascular magnetic resonance (CMR) perfusion imaging. METHODS AND RESULTS: In 42 patients with stable angina and suspected coronary artery disease (CAD), CMR perfusion imaging was performed. Fractional Flow Reserve (FFR) was measured in vessels with ≥50 % stenosis...
October 20, 2016: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
Vladimir Lakhter, Mohamad Alkhouli, Chad J Zack, Huaqing Zhao, Howard A Cohen, Brian P O'Neill, Brian O'Murchu, Alfred A Bove, Riyaz Bashir
BACKGROUND: Women with coronary artery disease are less likely to be revascularized than men based on angiography alone. Recent studies have shown that female patients have higher fractional flow reserve (FFR) values for a given severity of coronary stenosis. However, gender differences in coronary revascularization rates following FFR assessment are unknown. METHODS: The nationwide inpatient sample database was used to identify all patients who underwent FFR in the United States between January 2009 and December 2010...
October 18, 2016: Journal of Women's Health
Tetsuma Kawaji, Hiroki Shiomi, Hiroshi Morishita, Takeshi Morimoto, Charles A Taylor, Shotaro Kanao, Koji Koizumi, Satoshi Kozawa, Kazuhisa Morihiro, Hirotoshi Watanabe, Junichi Tazaki, Masao Imai, Naritatsu Saito, Satoshi Shizuta, Koh Ono, Kaori Togashi, Takeshi Kimura
Non-invasive fractional flow reserve measured by coronary computed tomography angiography (FFRCT) has demonstrated a high diagnostic accuracy for detecting coronary artery disease (CAD) in selected patients in prior clinical trials. However, feasibility of FFRCT in unselected population have not been fully evaluated. Among 60 consecutive patients who had suspected significant CAD by coronary computed tomography angiography (CCTA) and were planned to undergo invasive coronary angiography, 48 patients were enrolled in this study comparing FFRCT with invasive fractional flow reserve (FFR) without any exclusion criteria for the quality of CCTA image...
October 7, 2016: International Journal of Cardiovascular Imaging
H M Nef, O Dörr, H Möllmann, A Elsässer
Bifurcation lesions are a therapeutic challenge in the interventional treatment of coronary artery disease. Thus, consideration of anatomical aspects and selection of the most appropriate strategy for an individual bifurcation have an impact on the interventional outcome. Accordingly, assessment of the type of bifurcation stenosis, including the relevance of the side branches, vessel diameter and the angle between the two branches are critical for the optimal choice of interventional strategy. The fractional flow reserve (FFR) is a parameter that provides a measure of the severity of coronary stenosis and despite some limitations, FFR can be applied to bifurcation lesions...
October 7, 2016: Herz
Asim Rizvi, Bríain Ó Hartaigh, Paul Knaapen, Jonathon Leipsic, Leslee J Shaw, Daniele Andreini, Gianluca Pontone, Subha Raman, Muhammad Akram Khan, Michael Ridner, Faisal Nabi, Alessia Gimelli, James Jang, Jason Cole, Ryo Nakazato, Christopher Zarins, Donghee Han, Ji Hyun Lee, Jackie Szymonifika, Millie J Gomez, Quynh A Truong, Hyuk-Jae Chang, Fay Y Lin, James K Min
BACKGROUND: Coronary computed tomography angiography (CCTA) allows for non-invasive assessment of obstructive coronary artery disease (CAD) beyond measures of stenosis severity alone. This assessment includes atherosclerotic plaque characteristics (APCs) and calculation of fractional flow reserve (FFR) from CCTA (FFRCT). Similarly, stress imaging by myocardial perfusion scintigraphy (MPS) provides vital information. To date, the diagnostic performance of integrated CCTA assessment versus integrated MPS assessment for diagnosis of vessel-specific ischemia remains underexplored...
October 6, 2016: BMC Cardiovascular Disorders
Shengxian Tu, Jelmer Westra, Junqing Yang, Clemens von Birgelen, Angela Ferrara, Mariano Pellicano, Holger Nef, Matteo Tebaldi, Yoshinobu Murasato, Alexandra Lansky, Emanuele Barbato, Liefke C van der Heijden, Johan H C Reiber, Niels R Holm, William Wijns
OBJECTIVES: The aim of this prospective multicenter study was to identify the optimal approach for simple and fast fractional flow reserve (FFR) computation from radiographic coronary angiography, called quantitative flow ratio (QFR). BACKGROUND: A novel, rapid computation of QFR pullbacks from 3-dimensional quantitative coronary angiography was developed recently. METHODS: QFR was derived from 3 flow models with: 1) fixed empiric hyperemic flow velocity (fixed-flow QFR [fQFR]); 2) modeled hyperemic flow velocity derived from angiography without drug-induced hyperemia (contrast-flow QFR [cQFR]); and 3) measured hyperemic flow velocity derived from angiography during adenosine-induced hyperemia (adenosine-flow QFR [aQFR])...
October 10, 2016: JACC. Cardiovascular Interventions
Adriaan Coenen, Marisa M Lubbers, Akira Kurata, Atsushi Kono, Admir Dedic, Raluca G Chelu, Marcel L Dijkshoorn, Alexia Rossi, Robert-Jan M van Geuns, Koen Nieman
OBJECTIVES: To investigate the additional value of transmural perfusion ratio (TPR) in dynamic CT myocardial perfusion imaging for detection of haemodynamically significant coronary artery disease compared with fractional flow reserve (FFR). METHODS: Subjects with suspected or known coronary artery disease were prospectively included and underwent a CT-MPI examination. From the CT-MPI time-point data absolute myocardial blood flow (MBF) values were temporally resolved using a hybrid deconvolution model...
October 4, 2016: European Radiology
J Kikoïne, M Lebon, G Gouffran, D Millischer, S Cattan, O Nallet
A 54-year-old woman was hospitalized for an acute pulmonary oedema revealing a severe aortic stenosis (AS) associated with an aortic aneurysm and a left ventricular hypertrophy (LVH). The coronary angiography found an equivocal left main lesion. Fractional flow reserve (FFR) showed hemodynamic significance (FFR=0.78) and optical coherence tomography confirmed this result with a minimal lumen area of 4.9mm(2). FFR-guided percutaneous intervention is reported to improve outcome in patients with stable coronary disease...
September 28, 2016: Annales de Cardiologie et D'angéiologie
Joel Ramirez, Patrick O'Shaughnessy
The primary objective of this study was to compare the filter performance of a representative selection of uncertified dust masks relative to the filter performance of a set of NIOSH-approved N95 filtering face-piece respirators (FFRs). Five different models of commercially available dust masks were selected for this study. Filter penetration of new dust masks was evaluated against a sodium chloride aerosol. Breathing resistance (BR) of new dust masks and FFRs was then measured for 120 min while challenging the dust masks and FFRs with Arizona road dust (ARD) at 25°C and 30% relative humidity...
September 27, 2016: Journal of Occupational and Environmental Hygiene
Stefan Baumann, Matthias Renker, Svetlana Hetjens, Stephen R Fuller, Tobias Becher, Dirk Loßnitzer, Ralf Lehmann, Ibrahim Akin, Martin Borggrefe, Siegfried Lang, Julian L Wichmann, U Joseph Schoepf
RATIONALE AND OBJECTIVES: Invasive coronary angiography (ICA) with fractional flow reserve (FFR) assessment is the reference standard for the detection of hemodynamically relevant coronary lesions. We have investigated whether coronary computed tomography angiography (cCTA)-derived FFR (fractional flow reserve from coronary computed tomographic angiography [CT-FFR]) measurement improves diagnostic accuracy over cCTA. METHODS AND RESULTS: A literature search was performed for studies comparing invasive FFR, cCTA, and CT-FFR...
September 14, 2016: Academic Radiology
Sherri L LaVela, Carol Kostovich, Sara Locatelli, Megan Gosch, Aaron Eagan, Lewis Radonovich
BACKGROUND: Filtering face-piece respirators (FFRs) are worn to protect health care personnel from airborne particles; however, clinical studies have demonstrated that FFR adherence is relatively low in some settings, in part, due to discomfort and intolerance. The objective of this study was to develop and initially evaluate the psychometric properties of an instrument designed to measure the comfort and tolerability of FFRs. METHODS: Instrument items were developed through literature reviews, focus groups, and several iterations of ranking and refining by experts...
September 16, 2016: Journal of Occupational and Environmental Hygiene
Selim Topcu, Ibrahim Halil Tanboğa, Enbiya Aksakal, Uğur Aksu, Oktay Gulcu, Oğuzhan Birdal, Arif Arısoy, Arzu Kalaycı, Fatih Rifat Ulusoy, Serdar Sevimli
INTRODUCTION: Coronary fractional flow reserve (FFR) is recommended as the gold standard method in evaluating intermediate coronary stenoses. However, there are significant debates concerning the agents and the timing of the measurement. AIM: To compare the contrast medium induced Pd/Pa ratio (CMR) with the FFR. MATERIAL AND METHODS: We enrolled 28 consecutive patients with 34 intermediate lesions who underwent coronary FFR measurement by intracoronary (i...
2016: Postępy W Kardiologii Interwencyjnej, Advances in Interventional Cardiology
Kazuhiro Osawa, Toru Miyoshi, Takashi Miki, Yuji Koide, Yusuke Kawai, Kentaro Ejiri, Masatoki Yoshida, Shuhei Sato, Susumu Kanazawa, Hiroshi Ito
High diagnostic performance of noninvasive fractional flow reserve computed from CT (FFR-CT) was recently reported in prospective multicenter trials. The aims of this study were to evaluate the diagnostic accuracy of FFR-CT in clinical practice and to examine the lesion characteristics showing a mismatch between FFR-CT and invasive FFR. A total of 20 patients (29 vessels) with suspected coronary artery disease were included. All patients underwent invasive coronary angiography and invasive FFR according to coronary artery CT angiography (CCTA) findings...
September 13, 2016: Heart and Vessels
Paulo Eduardo Miamoto Dias, Geraldo Elias Miranda, Thiago Leite Beaini, Rodolfo Francisco Haltenhoff Melani
The oral cavity's importance in defining the facial region makes it a primary feature for forensic facial reconstruction (FFR). The aim of this study is to construct a pattern of reference for dimensions and proportions of the lips and establish parameters that may help estimate the vermilion borders' height dimensions and the mouth's width. By means of cone beam computed tomography, divided into two samples: sample 1 (n = 322; 137 male, 185 female) verified the linear distances delimited by anatomical landmarks in soft tissue...
2016: PloS One
Yuhei Kobayashi, Hiroyuki Okura, Yoji Neishi, Tomitaka Higa, Yukari Kobayashi, Shiro Uemura, Kiyoshi Yoshida
BACKGROUND: The induction of hyperemia is of importance to precisely assess the functional significance of coronary artery lesions with fractional flow reserve (FFR). Adenosine or ATP alone is used widely in this setting; however, little is known about the additive value of nicorandil, which acts as a nitrate and a K-ATP channel opener, to induce further hyperemia. PATIENTS AND METHODS: A total of 183 intermediate native coronary artery lesions from 112 patients were prospectively enrolled into this study...
September 8, 2016: Coronary Artery Disease
Joo Myung Lee, Chee Hae Kim, Bon-Kwon Koo, Doyeon Hwang, Jonghanne Park, Jinlong Zhang, Yaliang Tong, Ki-Hyun Jeon, Ji-In Bang, Minseok Suh, Jin Chul Paeng, Gi Jeong Cheon, Sang-Hoon Na, Jung-Min Ahn, Seung-Jung Park, Hyo-Soo Kim
BACKGROUND: Recent evidence suggests that the diagnostic accuracy of myocardial perfusion imaging is improved by quantifying stress myocardial blood flow (MBF) in absolute terms. We evaluated a comprehensive quantitative (13)N-ammonia positron emission tomography ((13)NH3-PET) diagnostic panel, including stress MBF, coronary flow reserve (CFR), and relative flow reserve (RFR) in conjunction with relative perfusion defect (PD) assessments to better detect functionally significant coronary artery stenosis...
September 2016: Circulation. Cardiovascular Imaging
Abdul Hakeem, Mohan M Edupuganti, Ahmed Almomani, Naga Venkata Pothineni, Jason Payne, Amjad M Abualsuod, Sabha Bhatti, Zubair Ahmed, Barry F Uretsky
BACKGROUND: Deferring percutaneous coronary intervention in nonischemic lesions by fractional flow reserve (FFR) is associated with excellent long-term prognosis in patients with stable ischemic heart disease (SIHD). Although FFR is increasingly used for clinical decision making in acute coronary syndrome (ACS) patients with intermediate lesions, its effect on long-term prognosis has not been well established. OBJECTIVES: This study investigated the clinical and prognostic utility of FFR in ACS patients with percutaneous coronary intervention deferred on the basis of nonischemic FFR...
September 13, 2016: Journal of the American College of Cardiology
E Şahan, S Şahan, M Karamanlıoğlu, M Gül, S Kalaycı, A Boyacı, F Dereağzı
OBJECTIVE: Coronary angiography has a limitation to determine the severity of intermediate stenosis (30-70%)1,2. Fractional flow reserve (FFR) is a method for the assessment of the intermediate stenosis severity3. The effect of coronary artery disease (CAD) severity on the FFR results is not clear. In this study, we aimed to expose the effect of CAD severity calculated with Syntax and Gensini scores on FFR results. PATIENTS AND METHODS: We scanned patients data (n=378) who had undergone fractional flow reserve measurements in our center...
August 2016: European Review for Medical and Pharmacological Sciences
Tobias Härle, Uwe Zeymer, Matthias Hochadel, Ralf Zahn, Sebastian Kerber, Bernhard Zrenner, Volker Schächinger, Bernward Lauer, Thorsten Runde, Albrecht Elsässer
BACKGROUND: There is growing evidence for beneficial prognostic and economic effects of FFR-guided treatment of stable coronary artery disease. We sought to evaluate the real-world use of FFR measurements in patients undergoing elective coronary angiography. METHODS AND RESULTS: We analyzed the data of the prospective ALKK coronary angiography and PCI registry including data of 38 hospitals from January 2010 to December 2013. A total of 100,977 patients undergoing coronary angiography were included...
September 6, 2016: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
T Härle, S Meyer, W Bojara, F Vahldiek, A Elsässer
INTRODUCTION: Intracoronary pressure measurements have improved assessment of angiographic intermediate coronary stenoses. Methodically, pressure equalization and actual measurements are frequently performed at different height levels, depending on the particular coronary territory analyzed. Considering a hypothetical influence of hydrostatic pressure and the supine position of the patient, differences in the results of intracoronary measurements between anterior and posterior vessels seem likely...
August 31, 2016: Herz
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