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https://www.readbyqxmd.com/read/29933938/rationale-and-design-of-advantage-additional-diagnostic-value-of-ct-perfusion-over-coronary-ct-angiography-in-stented-patients-with-suspected-in-stent-restenosis-or-coronary-artery-disease-progression-prospective-study
#1
Daniele Andreini, Saima Mushtaq, Gianluca Pontone, Edoardo Conte, Jeroen Sonck, Carlos Collet, Marco Guglielmo, Andrea Baggiano, Daniela Trabattoni, Stefano Galli, Piero Montorsi, Cristina Ferrari, Franco Fabbiocchi, Stefano De Martini, Andrea Annoni, Maria Elisabetta Mancini, Alberto Formenti, Marco Magatelli, Marta Resta, Elisa Consiglio, Giuseppe Muscogiuri, Cesare Fiorentini, Antonio L Bartorelli, Mauro Pepi
BACKGROUND: Recent studies demonstrated a significant improvement in the diagnostic performance of coronary CT angiography (CCTA) for the evaluation of in-stent restenosis (ISR). However, coronary stent assessment is still challenging, especially because of beam-hardening artifacts due to metallic stent struts and high atherosclerotic burden of non-stented segments. Adenosine-stress myocardial perfusion assessed by CT (CTP) recently demonstrated to be a feasible and accurate tool for evaluating the functional significance of coronary stenoses in patients with suspected coronary artery disease (CAD)...
June 18, 2018: Journal of Cardiovascular Computed Tomography
https://www.readbyqxmd.com/read/29923057/instantaneous-wave-free-ratio-and-fractional-flow-reserve-in-clinical-practice
#2
R Pisters, M Ilhan, L F Veenstra, B C G Gho, M Stein, J C A Hoorntje, S Rasoul
OBJECTIVES: To compare fractional flow reserve (FFR) and instantaneous wave-free ratio (iFR) measurements in an all-comer patient population with moderate coronary artery stenoses. BACKGROUND: Visual assessment of the severity of coronary artery stenoses is often discordant in moderate lesions. FFR allows reliable functional severity assessment in these cases but requires adenosine-induced hyperaemia with associated additional time, costs and side effects. The iFR is a hyperaemia-independent index...
June 19, 2018: Netherlands Heart Journal
https://www.readbyqxmd.com/read/29899591/3d-printed-cardiovascular-patient-specific-phantoms-used-for-clinical-validation-of-a-ct-derived-ffr-diagnostic-software
#3
Kelsey N Sommer, Lauren Shepard, Nitant Vivek Karkhanis, Vijay Iyer, Erin Angel, Michael F Wilson, Frank J Rybicki, Dimitrios Mitsouras, Stephen Rudin, Ciprian N Ionita
Purpose: 3D printed patient specific vascular models provide the ability to perform precise and repeatable benchtop experiments with simulated physiological blood flow conditions. This approach can be applied to CT-derived patient geometries to determine coronary flow related parameters such as Fractional Flow Reserve (FFR). To demonstrate the utility of this approach we compared bench-top results with non-invasive CT-derived FFR software based on a computational fluid dynamics algorithm and catheter based FFR measurements...
February 2018: Proceedings of SPIE
https://www.readbyqxmd.com/read/29895487/virtual-functional-assessment-of-coronary-stenoses-using-intravascular-ultrasound-imaging-a-proof-of-concept-pilot-study
#4
Panagiotis K Siogkas, Michail I Papafaklis, Lampros Lakkas, Themis P Exarchos, Dimitri Karmpaliotis, Ziad A Ali, Gualtiero Pelosi, Oberdan Parodi, Christos S Katsouras, Dimitrios I Fotiadis, Lampros K Michalis
AIMS: We aimed to investigate the performance of virtual functional assessment of coronary stenoses using intravascular ultrasound (IVUS)-based three-dimensional (3D) coronary artery reconstruction against the invasively measured fractional flow reserve (FFR). METHODS AND RESULTS: Twenty-two patients with either typical symptoms of stable angina or a positive stress test, who underwent IVUS and FFR, were included in this study. Five patients presented FFR values lower than the 0...
March 2, 2018: Heart, Lung & Circulation
https://www.readbyqxmd.com/read/29885695/ct-morphological-index-provides-incremental-value-to-machine-learning-based-ct-ffr-for-predicting-hemodynamically-significant-coronary-stenosis
#5
Mengmeng Yu, Zhigang Lu, Wenbin Li, Meng Wei, Jing Yan, Jiayin Zhang
AIMS: To study the diagnostic performance of the ratio of Duke jeopardy score (DJS) to the minimal lumen diameter (MLD) at coronary computed tomographic angiography (CCTA) and machine learning based CT-FFR for differentiating functionally significant from insignificant lesions, with reference to fractional flow reserve (FFR). METHODS AND RESULTS: Patients who underwent both coronary CTA and FFR measurement at invasive coronary angiography (ICA) within 2 weeks were retrospectively included in our study...
August 15, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29858919/intravenous-nicorandil-versus-adenosine-for-fractional-flow-reserve-measurement-a-crossover-randomized-study
#6
Takeshi Nishi, Hideki Kitahara, Yoshihide Fujimoto, Takashi Nakayama, Kengo Nagashima, Hideki Hanaoka, Yoshio Kobayashi
Nicorandil has vasodilatory effects on both the epicardial coronary arteries and the coronary microvasculature, thereby increasing coronary blood flow. The objective of the present study was to investigate the effectiveness of intravenous (IV) nicorandil infusion for fractional flow reserve (FFR) measurement. In this crossover randomized study, 49 patients underwent FFR measurement with a consecutive randomized order of patient-blind infusions of continuous IV adenosine administration and a single bolus IV administration of nicorandil...
June 1, 2018: Heart and Vessels
https://www.readbyqxmd.com/read/29858614/feasibility-of-dynamic-stress-201-tl-rest-99m-tc-tetrofosmin-single-photon-emission-computed-tomography-for-quantification-of-myocardial-perfusion-reserve-in-patients-with-stable-coronary-artery-disease
#7
Sangwon Han, Young-Hak Kim, Jung-Min Ahn, Soo-Jin Kang, Jungsu S Oh, Eonwoo Shin, Changhwan Sung, Sun Young Chae, Seung-Jung Park, Gillan Grimberg, Gil Kovalski, Dae Hyuk Moon
PURPOSE: We evaluated the feasibility of dynamic stress 201 Tl/rest 99m Tc-tetrofosmin SPECT imaging using a cardiac camera equipped with cadmium-zinc-telluride detectors for the quantification of myocardial perfusion reserve (MPR). METHODS: Subjects with stable known or suspected coronary artery disease (CAD) who had undergone or were scheduled to undergo fractional flow reserve (FFR) measurement were prospectively enrolled. Dynamic stress 201 Tl/rest 99m Tc-tetrofosmin SPECT imaging was performed using a dedicated multiple pinhole SPECT camera with cadmium-zinc-telluride detectors...
June 2, 2018: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29850808/the-performance-of-non-invasive-tests-to-rule-in-and-rule-out-significant-coronary-artery-stenosis-in-patients-with-stable-angina-a-meta-analysis-focused-on-post-test-disease-probability
#8
Juhani Knuuti, Haitham Ballo, Luis Eduardo Juarez-Orozco, Antti Saraste, Philippe Kolh, Anne Wilhelmina Saskia Rutjes, Peter Jüni, Stephan Windecker, Jeroen J Bax, William Wijns
Aims: To determine the ranges of pre-test probability (PTP) of coronary artery disease (CAD) in which stress electrocardiogram (ECG), stress echocardiography, coronary computed tomography angiography (CCTA), single-photon emission computed tomography (SPECT), positron emission tomography (PET), and cardiac magnetic resonance (CMR) can reclassify patients into a post-test probability that defines (>85%) or excludes (<15%) anatomically (defined by visual evaluation of invasive coronary angiography [ICA]) and functionally (defined by a fractional flow reserve [FFR] ≤0...
May 29, 2018: European Heart Journal
https://www.readbyqxmd.com/read/29807815/frequency-of-abnormal-fractional-flow-reserve-measurements-among-major-coronary-arteries
#9
Clay M Barbin, Anupama Vasudevan, James W Choi, Peter A McCullough, Jeffrey M Schussler, Ravi C Vallabhan, Robert C Stoler
BACKGROUND: Fractional flow reserve(FFR) is a validated tool for evaluating functional severity and guiding the revascularization of angiographically moderate coronary artery lesions. OBJECTIVE: To study if there is a higher frequency of positive FFR measurements in the left anterior descending(LAD) versus other major coronary arteries and also evaluate the differences in the total length of the stent placed. METHODS: A retrospective cohort study including all subjects (January 2011 to December 2015) who had fractional flow reserve (FFR) measured during coronary catheterization was conducted...
April 25, 2018: Cardiovascular Revascularization Medicine: Including Molecular Interventions
https://www.readbyqxmd.com/read/29793533/clinical-effect-of-selective-interventional-therapy-on-sub-acute-st-segment-elevation-myocardial-infarction-under-the-guidance-of-fractional-flow-reserve-and-coronary-arteriography
#10
Bing-Jian Wang, Jin Geng, Qian-Jun Li, Ting-Ting Hu, Biao Xu, Shu-Ren Ma
OBJECTIVE: This study aims to compare the clinical effects of selective interventional therapy (PCI) under the guidance of fractional flow reserve (FFR) and coronary arteriography. METHODS: Patients with sub-acute ST-segment elevation myocardial infarction (sub-acute STEMI), who were under selective PCI treatment between April 2012 and June 2014, were included into this study. These patients were divided into two groups, based on FFR measurements: FFR-PCI group and radiography-PCI group...
May 24, 2018: European Journal of Medical Research
https://www.readbyqxmd.com/read/29790719/less-is-more-as-less-as-reasonably-achievable-stenting-alaras-strategy-in-the-femoropopliteal-area
#11
Koen Deloose, Joren Callaert
BACKGROUND: Although evidence supports that the performance of drug coated balloons seems to be lesion complexity independent, it is quite clear that in long lesions, severe calcified lesions and chronic total occlusions, the bail out stent ratio is very high and that the "leaving nothing behind" strategy remains a dream in a lot of our daily cases. On the other side of the spectrum, "full metal jackets" of nitinol stents are creating even more problems. Stent fractures, intimal hyperplasia and reintervention difficulties complicate the recurrent vascular disease treatment...
May 23, 2018: Journal of Cardiovascular Surgery
https://www.readbyqxmd.com/read/29790478/validation-of-a-novel-non-hyperaemic-index-of-coronary-artery-stenosis-severity-the-resting-full-cycle-ratio-validate-rfr-study
#12
Johan Svanerud, Jung-Min Ahn, Allen Jeremias, Marcel van 't Veer, Ankita Gore, Akiko Maehara, Aaron Crowley, Nico H J Pijls, Bernard De Bruyne, Nils P Johnson, Barry Hennigan, Stuart Watkins, Colin Berry, Keith G Oldroyd, Seung-Jung Park, Ziad A Ali
AIMS: Randomised controlled trials have reported instantaneous wave-free ratio (iFR) to be non-inferior to fractional flow reserve (FFR) for major adverse cardiovascular events at one year; however, iFR is limited by sensitive landmarking of the pressure waveform, and the assumption that maximal flow and minimal resistance occur during a fixed period of diastole. We sought to validate the resting full-cycle ratio (RFR), a novel non-hyperaemic index of coronary stenosis severity based on unbiased identification of the lowest distal coronary pressure to aortic pressure ratio (Pd/Pa), independent of the ECG, landmark identification, and timing within the cardiac cycle...
May 23, 2018: EuroIntervention
https://www.readbyqxmd.com/read/29784622/non-invasive-fractional-flow-reserve-in-vessels-without-severe-obstructive-stenosis-is-associated-with-coronary-plaque-burden
#13
Mhairi K Doris, Yuka Otaki, Yoav Arnson, Balaji Tamarappoo, Markus Goeller, Heidi Gransar, Frances Wang, Sean Hayes, John Friedman, Louise Thomson, Piotr Slomka, Damini Dey, Daniel Berman
AIMS: Non-invasive fractional flow reserve derived from coronary CT angiography (FFRCT ) has been shown to be predictive of lesion-specific ischemia as assessed by invasive fractional flow reserve (FFR). However, in practice, clinicians are often faced with an abnormal distal FFRCT in the absence of a discrete obstructive lesion. Using quantitative plaque analysis, we sought to determine the relationship between an abnormal whole vessel FFRCT (V-FFRCT ) and quantitative measures of whole vessel atherosclerosis in coronary arteries without obstructive stenosis...
May 7, 2018: Journal of Cardiovascular Computed Tomography
https://www.readbyqxmd.com/read/29774108/prognostic-and-diagnostic-impact-of-fibrinogen-neutrophil-to-lymphocyte-ratio-and-platelet-to-lymphocyte-ratio-on-thymic-epithelial-tumors-outcome
#14
Stefan Janik, Thomas Raunegger, Philipp Hacker, Bahil Ghanim, Elisa Einwallner, Leonhard Müllauer, Ana-Iris Schiefer, Julia Moser, Walter Klepetko, Hendrik Jan Ankersmit, Bernhard Moser
Background: Peripheral blood-derived inflammation-based markers, such as Neutrophil-to-Lymphocyte Ratio (NLR), Platelet-to-Lymphocyte Ratio (PLR), and Fibrinogen have been identified as prognostic markers in various solid malignancies. Here we aimed to investigate the prognostic and diagnostic impact of NLR, PLR, and Fibrinogen in patients with thymic epithelial tumors (TETs). Results: Pretreatment Fibrinogen serum concentrations, NLRs and PLRs were highest in patients with TCs and advanced tumor stages...
April 24, 2018: Oncotarget
https://www.readbyqxmd.com/read/29769168/pressure-wire-compared-to-microcatheter-sensing-for-coronary-fractional-flow-reserve-the-perform-study
#15
Ziad A Ali, Yasir Parviz, Matthew Brinkman, Mitsuaki Matsumura, Björn Redfors, David A Brogno, Maria D Corral, Khady N Fall, Gary S Mintz, Gregg W Stone, Akiko Maehara, Allen Jeremias, Ajay J Kirtane
AIMS: Among technologies used to assess FFR, a monorail, sensor-tipped micro pressure catheter (PC) may be advantageous for delivery and re-assessment. We sought to determine whether the larger cross-sectional area of the PC influences FFR measurements compared to the pressure wire. METHODS AND RESULTS: PERFORM was a single-center, prospective study designed to determine the precision and accuracy of the PC compared with the pressure wire (PW) for measurement of FFR...
May 15, 2018: EuroIntervention
https://www.readbyqxmd.com/read/29769166/coronary-lesion-progression-as-assessed-by-fractional-flow-reserve-ffr-and-angiography
#16
Panagiotis Xaplanteris, Argyris Ntalianis, Bernard De Bruyne, Teresa Strisciuglio, Mariano Pellicano, Giovanni Ciccarelli, Anastasios Milkas, Emanuele Barbato
AIMS: To explore the evolution of coronary lesions that had repeated physiologic evaluation by FFR as an endpoint, describe the clinical significance of longitudinal FFR change (ΔFFR = FFR follow-up - FFR baseline), its correlation with angiographic indices and identify predictors of FFR follow-up. METHODS AND RESULTS: A retrospective, single-center analysis of 414 stenoses (331 patients) with consecutive FFR measurements at least six months apart was performed [median time interval: 24 (17, 37) months]...
May 15, 2018: EuroIntervention
https://www.readbyqxmd.com/read/29764252/response-properties-of-the-human-frequency-following-response-ffr-to-speech-and-non-speech-sounds-level-dependence-adaptation-and-phase-locking-limits
#17
Gavin Bidelman, Louise Powers
OBJECTIVE: The frequency-following response (FFR) is a neurophonic potential used to assess auditory neural encoding at subcortical stages. Despite the FFR's empirical and clinical utility, basic response properties of this evoked potential remain undefined. DESIGN: We measured FFRs to speech and nonspeech (pure tone, chirp sweeps) stimuli to quantify three key properties of this potential: level-dependence (I/O functions), adaptation and the upper limit of neural phase-locking...
May 15, 2018: International Journal of Audiology
https://www.readbyqxmd.com/read/29729354/gender-bias-in-the-sensory-representation-of-infant-cry
#18
S Devaraju Dhatri, G Nike Gnanateja, U Ajith Kumar, Sandeep Maruthy
The auditory neural pathway in females appears to be more sensitive to the cry of an infant (De Pisapia et al., 2013; Messina et al., 2016). Cortical responses in females have shown a distinct advantage compared to males in the auditory processing of infant cry. Such gender-bias in the cortical responses might emanate either at higher levels of processing such as cognitive and emotional processing or at the lower level representation of stimulus features. We assessed for a difference if any, between the two genders, in the sensory representation of an infant's cry...
June 21, 2018: Neuroscience Letters
https://www.readbyqxmd.com/read/29716756/coronary-microvascular-dysfunction-in-patients-with-stable-coronary-artery-disease-the-ce-marc-2-coronary-physiology-sub-study
#19
David Corcoran, Robin Young, David Adlam, Alex McConnachie, Kenneth Mangion, David Ripley, David Cairns, Julia Brown, Chiara Bucciarelli-Ducci, Andreas Baumbach, Rajesh Kharbanda, Keith G Oldroyd, Gerry P McCann, John P Greenwood, Colin Berry
BACKGROUND: In patients with angina undergoing invasive management, no obstructive coronary artery disease (NOCAD) is a common finding, and angina may persist following percutaneous coronary intervention (PCI). Coronary microvascular dysfunction may be relevant. We aimed to assess the proportion of patients presenting with suspected CAD who had coronary microvascular dysfunction. METHODS: Clinical Evaluation of Magnetic Resonance Imaging in Coronary Heart Disease 2 (CE-MARC 2) was a prospective multicenter randomised controlled trial of functional imaging versus guideline-based management in patients with suspected CAD...
September 1, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29713819/evaluation-of-the-risk-factors-for-ventricular-arrhythmias-secondary-to-qt-prolongation-induced-by-papaverine-injection-during-coronary-flow-reserve-studies-using-a-4-fr-angio-catheter
#20
Yoshitaka Okabe, Kanichi Otowa, Yasuhito Mitamura, Hisayoshi Murai, Soichiro Usui, Shuichi Kaneko, Masayuki Takamura
Estimation of the fractional flow reserve (FFR) is considered to be an established method by which to assess stable coronary artery stenosis. Induction of maximal coronary hyperemia is important during the FFR procedure. Papaverine has been reported to increase the risk of ventricular arrhythmia (VA). The purpose of the present study was to discover predictors of papaverine-induced VAs developing during FFR measurement. A total of 213 clinically stable patients were included in the study. FFRs were determined after intracoronary papaverine administration (12 mg into the left and 8 mg into the right coronary arteries)...
April 30, 2018: Heart and Vessels
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