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https://www.readbyqxmd.com/read/29437033/the-impact-of-objective-mathematical-analysis-during-fractional-flow-reserve-measurement-results-from-the-oma-ffr-study
#1
Martina I Sciola, Paul D Morris, Rebecca Gosling, Patricia V Lawford, D Rodney Hose, Julian P Gunn
AIMS: Fractional flow reserve (FFR), the reference-standard for guiding coronary revascularisation, is most commonly acquired during intravenous adenosine infusion. Results may be sensitive to system- and operator-dependent variability in how pressure data are analysed and interpreted. We developed a computational protocol to process the recorded pressure signals in a consistent manner to objectively quantify FFR. We studied the impact upon lesion (re)classification and compared this with the operator-selected FFR obtained during cardiac catheterisation...
February 13, 2018: EuroIntervention
https://www.readbyqxmd.com/read/29432130/combined-assessment-of-stress-myocardial-perfusion-cardiovascular-magnetic-resonance-and-flow-measurement-in-the-coronary-sinus-improves-prediction-of-functionally-significant-coronary-stenosis-determined-by-fractional-flow-reserve-in-multivessel-disease
#2
Shiro Nakamori, Hajime Sakuma, Kaoru Dohi, Masaki Ishida, Takashi Tanigawa, Akimasa Yamada, Shinichi Takase, Hiroshi Nakajima, Toshiki Sawai, Jun Masuda, Motonori Nagata, Yasutaka Ichikawa, Kakuya Kitagawa, Eitaro Fujii, Norikazu Yamada, Masaaki Ito
BACKGROUND: Recent studies using stress-rest perfusion cardiovascular magnetic resonance (CMR) demonstrated a close correlation between myocardial ischemia and reduced fractional flow reserve (FFR). However, its diagnostic concordance may be reduced in patients with multivessel disease. We sought to evaluate the concordance of adenosine stress-rest perfusion CMR for predicting reduced FFR, and to determine the additive value of measuring global coronary flow reserve (CFR) in the coronary sinus in multivessel disease...
January 26, 2018: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29411509/initial-experience-with-the-use-of-fractional-flow-reserve-in-the-hemodynamic-evaluation-of-transplant-renal-artery-stenosis
#3
Manuel Pereira Marques Gomes Júnior, Cláudia Maria Rodrigues Alves, Adriano Henrique Pereira Barbosa, Adriano Caixeta, Marcelo Costa Batista, José Osmar Medina Pestana, Antônio Carlos Carvalho
OBJECTIVE: To describe and standardize an original protocol for fractional flow reserve (FFR) pre and postangioplasty in an initial series of patients with clinically manifested transplant renal artery stenosis (TRAS). BACKGROUND: There is no data in the literature about the use of FFR in TRAS. METHODS: Patients with TRAS detected in a noninvasive study were referred to diagnostic angiography and stenosis considered visually severe (≥ 60%) were included...
February 7, 2018: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/29409717/comparison-of-invasively-measured-ffr-with-ffr-derived-from-coronary-ct-angiography-for-detection-of-lesion-specific-ischemia-results-from-a-pc-based-prototype-algorithm
#4
Jens Röther, Maximilian Moshage, Damini Dey, Chris Schwemmer, Monique Tröbs, Florian Blachutzik, Stephan Achenbach, Christian Schlundt, Mohamed Marwan
BACKGROUND: We evaluated the diagnostic accuracy of a novel prototype for on-site determination of CT-based FFR (cFFR) on a standard personal computer (PC) compared to invasively measured FFR in patients with suspected coronary artery disease. METHODS: A total of 91 vessels in 71 patients (mean age 65 ± 9 years) in whom coronary CT angiography had been performed due to suspicion of coronary artery disease, and who subsequently underwent invasive coronary angiography with FFR measurement were analyzed...
January 31, 2018: Journal of Cardiovascular Computed Tomography
https://www.readbyqxmd.com/read/29406855/effect-of-plaque-burden-and-morphology%C3%A2-on-myocardial-blood-flow-and%C3%A2-fractional-flow%C3%A2-reserve
#5
Roel S Driessen, Wijnand J Stuijfzand, Pieter G Raijmakers, Ibrahim Danad, James K Min, Jonathon A Leipsic, Amir Ahmadi, Jagat Narula, Peter M van de Ven, Marc C Huisman, Adriaan A Lammertsma, Albert C van Rossum, Niels van Royen, Paul Knaapen
BACKGROUND: Atherosclerotic plaque characteristics may affect downstream myocardial perfusion, as well as coronary lesion severity. OBJECTIVES: This study sought to evaluate the association between quantitative plaque burden and plaque morphology obtained using coronary computed tomography angiography (CTA) and quantitative myocardial perfusion obtained using [15O]H2O positron emission tomography (PET), as well as fractional flow reserve (FFR) derived invasively...
February 6, 2018: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/29401063/test-retest-reliability-of-dual-recorded-brainstem-versus-cortical-auditory-evoked-potentials-to-speech
#6
Gavin M Bidelman, Monique Pousson, Calli Dugas, Amy Fehrenbach
BACKGROUND: Auditory-evoked potentials have proven useful in the objective evaluation of sound encoding at different stages of the auditory pathway (brainstem and cortex). Yet, their utility for use in clinical assessment and empirical research relies critically on the precision and test-retest repeatability of the measure. PURPOSE: To determine how subcortical/cortical classes of auditory neural responses directly compare in terms of their internal consistency and test-retest reliability within and between listeners...
February 2018: Journal of the American Academy of Audiology
https://www.readbyqxmd.com/read/29401057/effects-of-early-and-late-arriving-room-reflections-on-the-speech-evoked-auditory-brainstem-response
#7
Rida Al Osman, Christian Giguère, Hilmi R Dajani
BACKGROUND: Room reverberation alters the acoustical properties of the speech signals reaching our ears, affecting speech understanding. Therefore, it is important to understand the consequences of reverberation on auditory processing. In perceptual studies, the direct sound and early reflections of reverberated speech have been found to constitute useful energy, whereas the late reflections constitute detrimental energy. PURPOSE: This study investigated how various components (direct sound versus early reflections versus late reflections) of the reverberated speech are encoded in the auditory system using the speech-evoked auditory brainstem response (ABR)...
February 2018: Journal of the American Academy of Audiology
https://www.readbyqxmd.com/read/29399070/analysis-of-the-clinical-value-of-fractional-flow-reserve-for-prognosis-evaluation-of-patients-of-percutaneous-coronary-intervention
#8
Qingxia Zhao, Zheng Ji, Xia Li, Yali Di, Haojun An, Bin Wei, Liming Yang, Wensheng Chen
We investigated the clinical value of fractional flow reserve (FFR) for the prognostic evaluation of patients with percutaneous coronary intervention. We enrolled 120 patients who were admitted to the hospital to undergo percutaneous coronary intervention for acute coronary syndromes between May 2014 and June 2015. The 120 patients were divided into two groups, the observation group and the control group, according to the post-surgery level of FFR. Each cohort contained 60 patients. These patients were divided into the occurrence group (n=45) and the non-occurrence group (n=75), classified according to the occurrence of major adverse cardiovascular events (MACE)...
January 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29380286/diagnostic-value-of-stress-thallium-201-rest-technetium-99m-sestamibi-sequential-dual-isotope-high-speed-myocardial-perfusion-imaging-for-the-detection-of-haemodynamically-relevant-coronary-artery-stenosis
#9
Gilles Barone-Rochette, Feras Zoreka, Loïc Djaileb, Nicolas Piliero, Alex Calizzano, Jean Louis Quesada, Alexis Broisat, Laurent Riou, Jacques Machecourt, Daniel Fagret, Gerald Vanzetto, Catherine Ghezzi
BACKGROUND: The aim of this study was to determine the diagnostic accuracy of stress thallium-201/rest technetium-99m-sestamibi sequential dual-isotope high-speed myocardial perfusion imaging (DI-HS-MPI) against invasively determined fractional flow reserve (FFR). METHODS: Fifty-four consecutive patients prospectively underwent DI-HS-MPI before invasive coronary angiography. Perfusion was scored visually by summed stress score on a patient and coronary territory basis...
January 29, 2018: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/29361444/prognostic-implication-of-functional-incomplete-revascularization-and-residual%C3%A2-functional-syntax-score-in-patients-with-coronary-artery-disease
#10
Ki Hong Choi, Joo Myung Lee, Bon-Kwon Koo, Chang-Wook Nam, Eun-Seok Shin, Joon-Hyung Doh, Tae-Min Rhee, Doyeon Hwang, Jonghanne Park, Jinlong Zhang, Kyung-Jin Kim, Xinyang Hu, Jianan Wang, Fei Ye, Shaoliang Chen, Junqing Yang, Jiyan Chen, Nobuhiro Tanaka, Hiroyoshi Yokoi, Hitoshi Matsuo, Hiroaki Takashima, Yasutsugu Shiono, Takashi Akasaka
OBJECTIVES: The aim of this study was to investigate the prognostic implication of functional incomplete revascularization (IR) and residual functional SYNTAX (Synergy Between Percutaneous Coronary Intervention With Taxus and Cardiac Surgery) score (rFSS) in comparison with 3-vessel fractional flow reserve (FFR) and residual SYNTAX score. BACKGROUND: IR is associated with poor clinical outcomes in patients who underwent percutaneous coronary intervention. METHODS: A total of 385 patients who underwent 3-vessel FFR measurement after stent implantation were included in this study...
January 11, 2018: JACC. Cardiovascular Interventions
https://www.readbyqxmd.com/read/29355991/a-functionally-personalized-boundary-condition-model-to-improve-estimates-of-fractional-flow-reserve-with-ct-ct-ffr
#11
Moti Freiman, Hannes Nickisch, Holger Schmitt, Pál Maurovich-Horvat, Patrick M Donnelly, Mani Vembar, Liran Goshen
PURPOSE: The purpose of this study is to develop and evaluate a functionally personalized boundary condition (BC) model for estimating the fractional flow reserve (FFR) from coronary computed tomography angiography (CCTA) using flow simulation (CT-FFR). MATERIALS AND METHODS: CCTA data of 90 subjects with subsequent invasive FFR in 123 lesions within 21 days (range: 0-83) were retrospectively collected. We developed a functionally-personalized BC model accounting specifically for the coronary micro-vascular resistance dependency on the coronary outlets pressure suggested by several physiological studies...
January 22, 2018: Medical Physics
https://www.readbyqxmd.com/read/29352380/integrated-prediction-of-lesion-specific-ischaemia-from-quantitative-coronary-ct-angiography-using-machine-learning-a-multicentre-study
#12
Damini Dey, Sara Gaur, Kristian A Ovrehus, Piotr J Slomka, Julian Betancur, Markus Goeller, Michaela M Hell, Heidi Gransar, Daniel S Berman, Stephan Achenbach, Hans Erik Botker, Jesper Moller Jensen, Jens Flensted Lassen, Bjarne Linde Norgaard
OBJECTIVES: We aimed to investigate if lesion-specific ischaemia by invasive fractional flow reserve (FFR) can be predicted by an integrated machine learning (ML) ischaemia risk score from quantitative plaque measures from coronary computed tomography angiography (CTA). METHODS: In a multicentre trial of 254 patients, CTA and invasive coronary angiography were performed, with FFR in 484 vessels. CTA data sets were analysed by semi-automated software to quantify stenosis and non-calcified (NCP), low-density NCP (LD-NCP, < 30 HU), calcified and total plaque volumes, contrast density difference (CDD, maximum difference in luminal attenuation per unit area) and plaque length...
January 19, 2018: European Radiology
https://www.readbyqxmd.com/read/29298341/3d-reconstruction-of-coronary-arteries-from-2d-angiographic-projections-using-non-uniform-rational-basis-splines-nurbs-for-accurate-modelling-of-coronary-stenoses
#13
Francesca Galassi, Mohammad Alkhalil, Regent Lee, Philip Martindale, Rajesh K Kharbanda, Keith M Channon, Vicente Grau, Robin P Choudhury
OBJECTIVE: Assessment of coronary stenosis severity is crucial in clinical practice. This study proposes a novel method to generate 3D models of stenotic coronary arteries, directly from 2D coronary images, and suitable for immediate assessment of the stenosis severity. METHODS: From multiple 2D X-ray coronary arteriogram projections, 2D vessels were extracted. A 3D centreline was reconstructed as intersection of surfaces from corresponding branches. Next, 3D luminal contours were generated in a two-step process: first, a Non-Uniform Rational B-Spline (NURBS) circular contour was designed and, second, its control points were adjusted to interpolate computed 3D boundary points...
2018: PloS One
https://www.readbyqxmd.com/read/29246917/acist-ffr-study-assessment-of-catheter-based-interrogation-and-standard-techniques-for-fractional-flow-reserve-measurement
#14
William F Fearon, Jeffrey W Chambers, Arnold H Seto, Ian J Sarembock, Ganesh Raveendran, Charlotte Sakarovitch, Lingyao Yang, Manisha Desai, Allen Jeremias, Matthew J Price
BACKGROUND: Measurement of fractional flow reserve (FFR) to guide coronary revascularization lags despite robust supportive data, partly because of the handling characteristics of traditional coronary pressure wires. An optical pressure-monitoring microcatheter, which can be advanced over a traditional coronary guidewire, facilitates FFR assessment but may underestimate pressure wire-derived FFR. METHODS AND RESULTS: In this prospective, multicenter trial, 169 patients underwent FFR assessment with a pressure wire alone and with a pressure microcatheter over the pressure wire...
December 2017: Circulation. Cardiovascular Interventions
https://www.readbyqxmd.com/read/29246913/postocclusional-hyperemia-for-fractional-flow-reserve-after-percutaneous-coronary-intervention
#15
Yoshiaki Kawase, Hiroyuki Omori, Masanori Kawasaki, Toru Tanigaki, Tetsuo Hirata, Syuuichi Okamoto, Hideaki Ota, Jun Kikuchi, Munenori Okubo, Hiroki Kamiya, Akihiro Hirakawa, Takahiko Suzuki, Hitoshi Matsuo
BACKGROUND: Postocclusional hyperemia caused by balloon occlusion is a potential alternative method of inducing hyperemia for measuring post-percutaneous coronary intervention fractional flow reserve (FFR). The aim of this study was to investigate postocclusional hyperemia as a method of inducing hyperemia. METHODS AND RESULTS: FFR measured by postocclusional hyperemia (FFRoccl) caused by balloon occlusion after percutaneous coronary intervention was compared with FFR measured by drug-induced hyperemia (FFR measured by intravenous ATP; and FFR measured by intracoronary papaverine injection [FFRpap]) in 98 lesions from 98 patients...
December 2017: Circulation. Cardiovascular Interventions
https://www.readbyqxmd.com/read/29246509/diagnostic-concordance-and-clinical-outcomes-in-patients-undergoing-fractional-flow-reserve-and-stress-echocardiography-for-the-assessment-of-coronary-stenosis-of-intermediate-severity
#16
Sothinathan Gurunathan, Asrar Ahmed, Anastasia Vamvakidou, Ihab S Ramzy, Mohammed Akhtar, Aamir Ali, Nikos Karogiannis, Spiros Zidros, Gothandaraman Balaji, Grace Young, Ahmed Elghamaz, Roxy Senior
BACKGROUND: The ischemic consequences of coronary artery stenosis can be assessed by invasive fractional flow reserve (FFR) or by noninvasive imaging. We sought to determine (1) the concordance between wall thickening assessment during clinically indicated stress echocardiography (SE) and FFR measurements and (2) the factors associated with hard events in these patients. METHODS: Two hundred twenty-three consecutive patients who underwent SE and invasive FFR measurements in close succession were analyzed retrospectively for diagnostic concordance and clinical outcomes...
December 12, 2017: Journal of the American Society of Echocardiography
https://www.readbyqxmd.com/read/29246484/testing-native-language-neural-commitment-at-the-brainstem-level-a-cross-linguistic-investigation-of-the-association-between-frequency-following-response-and-speech-perception
#17
Luodi Yu, Yang Zhang
A current topic in auditory neurophysiology is how brainstem sensory coding contributes to higher-level perceptual, linguistic and cognitive skills. This cross-language study was designed to compare frequency following responses (FFRs) for lexical tones in tonal (Mandarin Chinese) and non-tonal (English) language users and test the correlational strength between FFRs and behavior as a function of language experience. The behavioral measures were obtained in the Garner paradigm to assess how lexical tones might interfere with vowel category and duration judgement...
December 12, 2017: Neuropsychologia
https://www.readbyqxmd.com/read/29240450/letter-in-response-to-tp-e-interval-and-tp-e-qt-ratio-before-and-after-catheter-ablation-in-patients-with-premature-ventricular-complexes
#18
Ahmet Korkmaz, Deniz Sahin, Umit Guray
AIM: Recently fragmented QRS (fQRS) on ECG has been introduced as a predictor of myocardial scarring and myocardial ischemia in coronary artery disease. OBJECTIVE: The aim of this study was to investigate the relationship between fQRS and fractional flow reserve (FFR) results in patients with the intermediate degree of coronary artery stenosis. METHODS: A total of 301 consecutive patients who underwent coronary angiography and FFR measurement for intermediate coronary artery stenosis were included in the study...
December 14, 2017: Biomarkers in Medicine
https://www.readbyqxmd.com/read/29226818/rate-response-programming-tailored-to%C3%A2-the-force-frequency-relationship-improves-exercise-tolerance-in-chronic-heart-failure
#19
John Gierula, Maria F Paton, Judith E Lowry, Haqeel A Jamil, Rowenna Byrom, Michael Drozd, Jack O Garnham, Richard M Cubbon, David A Cairns, Mark T Kearney, Klaus K Witte
OBJECTIVES: This study sought to examine whether the heart rate (HR) at which the force-frequency relationship (FFR) slope peaks (critical HR) could be used to tailor HR response in chronic heart failure (CHF) patients with cardiac pacemakers and whether this favorably influences exercise capacity. BACKGROUND: CHF secondary to left ventricular (LV) systolic dysfunction is characterized by blunting of the positive relationship between HR and LV contractility known as the FFR...
November 27, 2017: JACC. Heart Failure
https://www.readbyqxmd.com/read/29197253/deep-learning-analysis-of-the-myocardium-in-coronary-ct-angiography-for-identification-of-patients-with-functionally-significant-coronary-artery-stenosis
#20
Majd Zreik, Nikolas Lessmann, Robbert W van Hamersvelt, Jelmer M Wolterink, Michiel Voskuil, Max A Viergever, Tim Leiner, Ivana Išgum
In patients with coronary artery stenoses of intermediate severity, the functional significance needs to be determined. Fractional flow reserve (FFR) measurement, performed during invasive coronary angiography (ICA), is most often used in clinical practice. To reduce the number of ICA procedures, we present a method for automatic identification of patients with functionally significant coronary artery stenoses, employing deep learning analysis of the left ventricle (LV) myocardium in rest coronary CT angiography (CCTA)...
November 26, 2017: Medical Image Analysis
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