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https://www.readbyqxmd.com/read/29675734/co-culture-system-of-hepatocytes-and-endothelial-cells-two-in-vitro-approaches-for-enhancing-liver-specific-functions-of-hepatocytes
#1
Gaoxiong Wang, Youshi Zheng, Yingchao Wang, Zhixiong Cai, Naishun Liao, Jingfeng Liu, Wenmin Zhang
Although hepatocyte transplantation and bioartificial liver support system provide new promising opportunities for those patients waiting for liver transplantation, hepatocytes are easily losing liver-specific functions by using the common in vitro cultured methods. The co-culture strategies with mimicking the in vivo microenvironment would facilitate the maintenance of liver-specific functions of hepatocytes. Considering that hepatocytes and endothelial cells (ECs) account for 80-90% of total cell populations in the liver, hepatocytes and ECs were directly co-cultured with hepatic stellate cells (HSCs) or adipose tissue-derived stem cells (ADSCs) at a ratio of 700:150:3 or 14:3:3 in the present study, and the liver-specific functions were carefully analyzed...
April 19, 2018: Cytotechnology
https://www.readbyqxmd.com/read/29534556/strengthening-emergency-care-systems-to-mitigate-public-health-challenges-arising-from-influxes-of-individuals-with-different-socio-cultural-backgrounds-to-a-level-one-emergency-center-in-south-east-europe
#2
Michèle Twomey, Ana Šijački, Gert Krummrey, Tyson Welzel, Aristomenis K Exadaktylos, Marko Ercegovac
Emergency center visits are mostly unscheduled, undifferentiated, and unpredictable. A standardized triage process is an opportunity to obtain real-time data that paints a picture of the variation in acuity found in emergency centers. This is particularly pertinent as the influx of people seeking asylum or in transit mostly present with emergency care needs or first seek help at an emergency center. Triage not only reduces the risk of missing or losing a patient that may be deteriorating in the waiting room but also enables a time-critical response in the emergency care service provision...
March 12, 2018: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29532263/adding-a-speed-accuracy-trade-off-to-discrete-state-models-a-comment-on-heck-and-erdfelder-2016
#3
Jeffrey J Starns
Heck and Erdfelder (2016) developed a model that extends discrete-state multinomial processing tree models to response time (RT) data. Their model is an important advance, but it does not have a mechanism to produce the speed-accuracy trade-off, the bedrock empirical observation that rushed decisions are less accurate. I present a similar model, the "discrete-race" model, with a simple mechanism for the speed-accuracy trade-off. In the model, information that supports detection of the stimulus type is available for some proportion of items and unavailable for others...
March 12, 2018: Psychonomic Bulletin & Review
https://www.readbyqxmd.com/read/29024154/time-required-for-a-standard-sunscreen-to-become-effective-following-application-a-uv-photography-study
#4
María Victoria de Gálvez, José Aguilera, Emilio Antonio Buendía, Cristina Sánchez-Roldán, Enrique Herrera-Ceballos
Sunscreens are recommended that it should be applied generously (2 mg cm(-2) ) half an hour before exposure and reapplied every 2 hours(1,2) . It is not, however, always easy to apply in normal life (e.g., children doing outdoor activities at school or beachgoers who have to travel some distance to get to the sea) and in addition, sunscreen can be rubbed off or displaced by friction from clothing during the wait time and lose efficacy.The aim of this study was to determine the time needed for a sunscreen to offer optimal protection from the moment of application...
October 10, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28873796/shopcomm-community-supported-online-shopping-for-older-adults
#5
Katerina Gorkovenko, Garreth W Tigwell, Christopher S Norrie, Miriam Waite, Daniel Herron
The United Kingdom has an ageing population whose members experience significant life transitions as they grow older, for example, losing mobility due to deteriorating health. For these adults, digital technology has the potential to sustain their independence and improve their quality of life. However older adults can be reluctant to use digital solutions. In this paper, we review a local charity providing a grocery shopping service for older adults who are unable to go themselves. We explore how older adults perceive the benefits and drawbacks of both physical and digital shopping...
2017: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/28725404/age-dependent-male-mating-tactics-in-a-spider-mite-a-life-history-perspective
#6
Yukie Sato, Peter T Rühr, Helmut Schmitz, Martijn Egas, Alexander Blanke
Males often fight with rival males for access to females. However, some males display nonfighting tactics such as sneaking, satellite behavior, or female mimicking. When these mating tactics comprise a conditional strategy, they are often thought to be explained by resource holding potential (RHP), that is, nonfighting tactics are displayed by less competitive males who are more likely to lose a fight. The alternative mating tactics, however, can also be explained by life-history theory, which predicts that young males avoid fighting, regardless of their RHP, if it pays off to wait for future reproduction...
October 2016: Ecology and Evolution
https://www.readbyqxmd.com/read/28663074/impact-of-preoperative-wait-time-due-to-insurance-mandated-medically-supervised-diets-on-weight-loss-after-sleeve-gastrectomy-are-patients-losing-momentum
#7
Lee D Ying, Andrew J Duffy, Kurt E Roberts, Saber Ghiassi, Matthew O Hubbard, Geoffrey S Nadzam
BACKGROUND: Few studies have examined whether preoperative period length, as defined by the amount of time from enrollment in a surgical weight loss program to the day of surgery, affects postoperative weight loss. OBJECTIVES: To identify associations between preoperative period length and postoperative weight loss. SETTING: Single surgeon at an academic medical center in the United States. METHODS: Retrospective chart review in 109 consecutive patients undergoing sleeve gastrectomy from 2014-2015...
May 23, 2017: Surgery for Obesity and related Diseases: Official Journal of the American Society for Bariatric Surgery
https://www.readbyqxmd.com/read/28592680/chimpanzees-bonobos-and-children-successfully-coordinate-in-conflict-situations
#8
Alejandro Sánchez-Amaro, Shona Duguid, Josep Call, Michael Tomasello
Social animals need to coordinate with others to reap the benefits of group-living even when individuals' interests are misaligned. We compare how chimpanzees, bonobos and children coordinate their actions with a conspecific in a Snowdrift game, which provides a model for understanding how organisms coordinate and make decisions under conflict. In study 1, we presented pairs of chimpanzees, bonobos and children with an unequal reward distribution. In the critical condition, the preferred reward could only be obtained by waiting for the partner to act, with the risk that if no one acted, both would lose the rewards...
June 14, 2017: Proceedings. Biological Sciences
https://www.readbyqxmd.com/read/28457406/comparison-of-the-results-of-living-donor-liver-transplantation-due-to-acute-liver-failure-and-biliary-atresia-in-a-quaternary-center
#9
COMPARATIVE STUDY
L Éboli, A C Tannuri, N Gibelli, T Silva, P Braga, U Tannuri
OBJECTIVE: The objective of this study was to compare the complications, outcomes, and survival prevalence in patients undergoing living donor liver transplantation due to biliary atresia (BA) or acute liver failure (ALF). RESULTS: In the period of June 1998-July 2016, 199 children underwent living transplantation due to BA or ALF. Of these 199, 184 were included in the analysis. The average age, weight, and body mass index of BA patients were lower than those of ALF (P < ...
May 2017: Transplantation Proceedings
https://www.readbyqxmd.com/read/28453244/a-cap-on-medicaid-how-block-grants-per-capita-caps-and-capped-allotments-might-fundamentally-change-the-safety-net
#10
Haleigh Mager-Mardeusz, Cosima Lenz, Gerald F Kominski
Changing the Medicaid program is a top priority for the Republican party. Common themes from GOP proposals include converting Medicaid from a jointly financed entitlement benefit to a form of capped federal financing. While proponents of this reform argue that it would provide greater flexibility and a more predictable budget for state governments, serious consequences would likely result for Medicaid enrollees and state governments. Under all three scenarios promoted by Republicans--block grants, capped allotments, and per capita caps—most states would face increased costs...
April 2017: Policy Brief
https://www.readbyqxmd.com/read/28343554/prioritization-of-patients-for-publicly-funded-ivf-in-ontario-a-survey-of-fertility-centres
#11
Tamas Gotz, Claire Jones
OBJECTIVE: On December 21, 2015, Ontario began funding one cycle of IVF for any Ontarian under age 43, with a program cap of 5000 cycles per year, which is below expected demand. Our objective was to determine how fertility clinics are prioritizing patients for limited-funded IVF cycles. METHODS: An electronic survey was emailed to medical directors of all 25 fertility clinics providing funded IVF in Ontario. RESULTS: From January to March 2016, 22 (88%) of the clinics responded...
March 2017: Journal of Obstetrics and Gynaecology Canada: JOGC, Journal D'obstétrique et Gynécologie du Canada: JOGC
https://www.readbyqxmd.com/read/28260448/pathology-results-at-autopsy-in-brain-dead-patients-with-brain-tumors
#12
Farahnaz Sadegh Beigee, Shagin Shahryari, Meysam Mojtabaee, Mihan Pourabdollah Toutkaboni
OBJECTIVES: Brain tumors are the most challenging causes of brain deaths due to the lack of pathology results in many cases. It is not uncommon to find a brain tumor in a brain-dead patient with no pathology results or neuroradiology reports available; this would exclude the deceased from organ donation. The mortality that occurs while patients are on transplant wait lists motivated us to find a solution to prevent losing brain-dead patients as potential donors. We present our experiences in autopsy examinations of brain tumors and the results of frozen-section pathology...
February 2017: Experimental and Clinical Transplantation
https://www.readbyqxmd.com/read/28122320/revisional-bariatric-surgery-in-a-transplant-patient
#13
Salman Al Sabah, Eliana Al Haddad
INTRODUCTION: A BMI of over 35-45kg/m2 is deemed the upper limit for considering a patient for a renal transplant. Voluntary weight loss attempts are a major concern for patients while on hemodialysis, however, bariatric surgeries have opened up a new door to notable weight loss results, even demonstrating significant improvements of patients' diabetic profile and hypertension. CASE REPORT: Case of a 52-year-old male with a BMI of 42 in end-stage renal disease, that needed a kidney transplant but was ineligible to be placed on the waiting list due to his weight...
2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/27883321/body-size-and-outcomes-in-dialysis-and-transplant-patients-does-it-matter
#14
REVIEW
Mehmet Sukru Sever
The terminologies of "body size", "body mass index (BMI)", "body weight", "large BMI" and "obesity" are controversial for defining the effects of "adiposity" or "fat excess" on the outcomes of dialysis and transplant patients. However, probably these terminologies will be continued to be used in the future as well, because of being older and simpler terminologies. In the general population obesity is a powerful risk factor for cardiovascular morbidity and mortality, while, it conferred a survival advantage to dialysis patients...
November 1, 2016: Prilozi (Makedonska Akademija Na Naukite i Umetnostite. Oddelenie za Medicinski Nauki)
https://www.readbyqxmd.com/read/27808099/hydrogenated-vacancies-lock-dislocations-in-aluminium
#15
Degang Xie, Suzhi Li, Meng Li, Zhangjie Wang, Peter Gumbsch, Jun Sun, Evan Ma, Ju Li, Zhiwei Shan
Due to its high diffusivity, hydrogen is often considered a weak inhibitor or even a promoter of dislocation movements in metals and alloys. By quantitative mechanical tests in an environmental transmission electron microscope, here we demonstrate that after exposing aluminium to hydrogen, mobile dislocations can lose mobility, with activating stress more than doubled. On degassing, the locked dislocations can be reactivated under cyclic loading to move in a stick-slip manner. However, relocking the dislocations thereafter requires a surprisingly long waiting time of ∼10(3) s, much longer than that expected from hydrogen interstitial diffusion...
November 3, 2016: Nature Communications
https://www.readbyqxmd.com/read/27756351/hockey-fans-in-training-hockey-fit-pilot-study-protocol-a-gender-sensitized-weight-loss-and-healthy-lifestyle-program-for-overweight-and-obese-male-hockey-fans
#16
RANDOMIZED CONTROLLED TRIAL
Dawn P Gill, Wendy Blunt, Ashleigh De Cruz, Brendan Riggin, Kate Hunt, Guangyong Zou, Shannon Sibbald, Karen Danylchuk, Merrick Zwarenstein, Cindy M Gray, Sally Wyke, Christopher Bunn, Robert J Petrella
BACKGROUND: Effective approaches that engage men in weight loss and lifestyle change are important because of worldwide increases, including in Canada, in obesity and chronic diseases. Football Fans in Training (FFIT), developed in Scotland, successfully tackled these problems by engaging overweight/obese male football fans in sustained weight loss and positive health behaviours, through program deliveries at professional football stadia. METHODS: Aims: 1) Adapt FFIT to hockey within the Canadian context and integrate with HealtheSteps™ (evidence-based lifestyle program) to develop Hockey Fans in Training (Hockey FIT); 2) Explore potential for Hockey FIT to help overweight/obese men lose weight and improve other outcomes by 12 weeks, and retain these improvements to 12 months; 3) Evaluate feasibility of recruiting and retaining overweight/obese men; 4) Evaluate acceptability of Hockey FIT; and 5) Conduct program optimization via a process evaluation...
October 19, 2016: BMC Public Health
https://www.readbyqxmd.com/read/27729475/primary-seed-dormancy-a-temporally-multilayered-riddle-waiting-to-be-unlocked
#17
REVIEW
Hicham Chahtane, Woohyun Kim, Luis Lopez-Molina
Primary seed dormancy is an important adaptive plant trait whereby seed germination is blocked under conditions that would otherwise be favorable for germination. This trait is found in newly produced mature seeds of many species, but not all. Once produced, dry seeds undergo an aging time period, called dry after-ripening, during which they lose primary dormancy and gradually acquire the capacity to germinate when exposed to favorable germination conditions. Primary seed dormancy has been extensively studied not only for its scientific interest but also for its ecological, phenological, and agricultural importance...
February 1, 2017: Journal of Experimental Botany
https://www.readbyqxmd.com/read/27619231/ready-set-go-a-cross-sectional-survey-to-understand-priorities-and-preferences-for-multiple-health-behaviour-change-in-a-highly-disadvantaged-group
#18
Natasha Noble, Christine Paul, Robert Sanson-Fisher, Heidi Turon, Nicole Turner, Katherine Conigrave
BACKGROUND: Socially disadvantaged groups, such as Aboriginal Australians, tend to have a high prevalence of multiple lifestyle risk factors, increasing the risk of disease and underscoring the need for services to address multiple health behaviours. The aims of this study were to explore, among a socially disadvantaged group of people attending an Aboriginal Community Controlled Health Service (ACCHS): a) readiness to change health behaviours; b) acceptability of addressing multiple risk factors sequentially or simultaneously; and c) preferred types of support services...
September 13, 2016: BMC Health Services Research
https://www.readbyqxmd.com/read/27534874/from-chronic-kidney-disease-to-kidney-transplantation-the-impact-of-obesity-and-its-treatment-modalities
#19
REVIEW
Brian Camilleri, Julie M Bridson, Ajay Sharma, Ahmed Halawa
Obesity is associated with worse short-term outcomes after kidney transplantation but the effect on long-term outcomes is unknown. Although some studies have reported worse outcomes for obese recipients when compared to recipients with a BMI in the normal range, obese recipients who receive a transplant have better outcomes than those who remain wait-listed. Whether transplant candidates should be advised to lose weight before or after transplant has been debated and this is mainly due to the gap in the literature linking pre-transplant weight loss with better outcomes post-transplantation...
October 2016: Transplantation Reviews
https://www.readbyqxmd.com/read/27426708/problems-faced-by-antiretroviral-arv-drug-users-in-kathmandu
#20
J Karki, S Shakya
BACKGROUND: Antiretroviral Therapy (ART) offers an opportunity to improve the prognosis and quality of life of People Living with HIV/AIDS (PLHIV). However, inability to achieve adherence even after drug introduction in Nepal is a matter of concern. Some efforts are to be applied in order to lend a hand to identify and minimize these problems. This study aims to assess the problems faced by antiretroviral drug users attending ART centers of Kathmandu. METHODS: A descriptive study was carried out in Sukraraj Tropical and Infectious Disease Control Hospital, Teku and Bir Hospital in 2071...
January 2016: Journal of Nepal Health Research Council
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