Donna Wilcock, Gregory Jicha, Deborah Blacker, Marilyn S Albert, Lina M D'Orazio, Fanny M Elahi, Myriam Fornage, Jason D Hinman, Janice Knoefel, Joel Kramer, Richard J Kryscio, Melissa Lamar, Abhay Moghekar, Jillian Prestopnik, John M Ringman, Gary Rosenberg, Abhay Sagare, Claudia L Satizabal, Julie Schneider, Sudha Seshadri, Sandeepa Sur, Russell P Tracy, Sevil Yasar, Victoria Williams, Herpreet Singh, Lidiya Mazina, Karl G Helmer, Roderick A Corriveau, Kristin Schwab, Pia Kivisäkk, Steven M Greenberg
The concept of vascular contributions to cognitive impairment and dementia (VCID) derives from more than two decades of research indicating that (1) most older individuals with cognitive impairment have post mortem evidence of multiple contributing pathologies and (2) along with the preeminent role of Alzheimer's disease (AD) pathology, cerebrovascular disease accounts for a substantial proportion of this contribution. Contributing cerebrovascular processes include both overt strokes caused by etiologies such as large vessel occlusion, cardioembolism, and embolic infarcts of unknown source, and frequently asymptomatic brain injuries caused by diseases of the small cerebral vessels...
April 2021: Alzheimer's & Dementia: the Journal of the Alzheimer's Association