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https://www.readbyqxmd.com/read/28915439/alpha-mangostin-suppresses-interleukin-1%C3%AE-induced-apoptosis-in-rat-chondrocytes-by-inhibiting-the-nf-%C3%AE%C2%BAb-signaling-pathway-and-delays-the-progression-of-osteoarthritis-in-a-rat-model
#1
Tianlong Pan, Rong Chen, Dengying Wu, Ningyu Cai, Xuchao Shi, Bin Li, Jun Pan
Osteoarthritis (OA) is a chronic degenerative joint disease that is characterized by progressive joint dysfunction and pain. Apoptosis and catabolism in chondrocytes play critical roles in the development of OA. Alpha-Mangostin (α-MG), one of the main components of the mangosteen, has been reported to have anti-apoptotic, anti-inflammatory and antioxidant effects. We investigated the therapeutic effects of α-MG on OA through experiments on rat chondrocytes in vitro and in a rat model of OA induced by destabilization of the medial meniscus (DMM)...
September 12, 2017: International Immunopharmacology
https://www.readbyqxmd.com/read/28906038/%C3%AE-carotene-suppresses-porphyromonas-gingivalis-lipopolysaccharide-mediated-cytokine-production-in-thp-1-monocytes-cultured-with-high-glucose-condition
#2
Yukari Kajiura, Yasufumi Nishikawa, Jung Hwan Lew, Jun-Ichi Kido, Toshihiko Nagata, Koji Naruishi
Periodontitis is associated with development of diabetes mellitus. Although lipopolysaccharide (LPS) of Porphyromonas gingivalis (Pg), a major pathogen of periodontitis, may lead the progression of diabetes complications, the precise mechanisms are unclear. We, therefore, investigated the effects of β-carotene on production of Pg LPS-induced inflammatory cytokines in human monocytes cultured high glucose (HG) condition. THP-1 cells were cultured under 5.5 mM or 25 mM glucose conditions, and cells were stimulated with Pg LPS...
September 14, 2017: Cell Biology International
https://www.readbyqxmd.com/read/28899698/betulinic-acid-derivative-ba5-a-dual-nf-kb-calcineurin-inhibitor-alleviates-experimental-shock-and-delayed-hypersensitivity
#3
Cássio Santana Meira, Renan Fernandes do Espírito Santo, Tatiana Barbosa Dos Santos, Iasmim Diniz Orge, Dahara Keyse Carvalho Silva, Elisalva Teixeira Guimarães, Luciana Souza de Aragão França, José Maria Barbosa-Filho, Diogo Rodrigo Magalhães Moreira, Milena Botelho Pereira Soares
Betulinic acid (BA) is a naturally occurring triterpenoid with several biological properties already described, including immunomodulatory activity. Here we investigated the immunomodulatory activity of eight semi-synthetic amide derivatives of betulinic acid. Screening of derivatives BA1-BA8 led to the identification of compounds with superior immunomodulatory activity than BA on activated macrophages and lymphocytes. BA5, the most potent derivative, inhibited nitric oxide and TNFα production in a concentration-dependent manner, and decreased NF-κB activation in Raw 264...
September 9, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/28892661/inhibition-of-c-rel-using-sirna-increased-apoptosis-and-decreased-proliferation-in-pre-b-all-blasts-therapeutic-implications
#4
Seyedeh Momeneh Mohammadi, Daryosh Mohammadnejad, Abbas Ali Hosseinpour Feizi, Ali Akbar Movassaghpour, Soheila Montazersaheb, Hojjatollah Nozad Charoudeh
The c-Rel transcription factor is a unique member of the NF-kB family that has a role in apoptosis, proliferation and cell survival. Overexpression of c-Rel is detected in many human B cell tumors, including B-cell leukemia and several cancers. The study aimed to investigate the effects of c-Rel siRNA on the proliferation and apoptosis of relapsed pre-B acute leukemia cells. The c-Rel siRNA was transfected into Leukemia cells using an Amaxa cell line Nucleofector kit L (Lonza). Quantitative real-time RT-PCR (qRT-PCR) and western blot were done to measure the expression levels of mRNA and protein, respectively...
August 26, 2017: Leukemia Research
https://www.readbyqxmd.com/read/28890293/epidermal-barrier-reaction-to-an-in-vitro-psoriatic-microenvironment
#5
Elena Donetti, Laura Cornaghi, Francesca Arnaboldi, Federica Ricceri, Leonardo Pescitelli, Martina Maiocchi, Francesco Carriero, Franz Baruffaldi Preis, Francesca Prignano
Keratinocytes (KCs) and Langerhans cells (LCs) contribute to create the epidermal barrier. To form a functional epidermis, KCs express filaggrin and Toll-like Receptors (TLRs). LCs are the first line of epidermal defence and can be activated by interleukin (IL)-17 and Tumor Necrosis Factor (TNF)-alpha. In psoriasis, an alteration of TLR expression, a defective expression of filaggrin, and LC activation occur. In organotypic cultures of human skin we investigated the interplay between IL-17 and TNF-alpha on i) expression of filaggrin, TLR2, 7 and 9, and Nuclear Factor (NF)-kB localization by immunofluorescence and ii) LC ultrastructural features by transmission electron microscopy...
September 7, 2017: Experimental Cell Research
https://www.readbyqxmd.com/read/28888416/toll-like-receptors-in-systemic-sclerosis-an-emerging-target
#6
REVIEW
Steven O'Reilly
Pattern Recognition Receptors are critical receptors that elicit an immune response upon their activation that culminates in activation of NF-KB and cytokine secretion. Key among these receptors are the Toll-Like Receptors (TLRs). These evolutionary conserved receptors form a key part in the defence against various pathogens and comprise a key part of the innate immune system. Systemic sclerosis is an autoimmune disease in which a breach of tolerance has occurred and leads to fulminant autoimmunity, dysregulated cytokines, pro-fibrotic mediators and activation of fibroblasts leading to fibrosis via collagen deposition...
September 6, 2017: Immunology Letters
https://www.readbyqxmd.com/read/28884970/a-dithiol-compound-binds-to-the-zinc-finger-protein-traf6-and-suppresses-its-ubiquitination
#7
Ryoko Koga, Mohamed O Radwan, Tomohiko Ejima, Yosuke Kanemaru, Hiroshi Tateishi, Taha F S Ali, Halil Ibrahim Ciftci, Yuri Shibata, Yuu Taguchi, Jun-Ichiro Inoue, Masami Otsuka, Mikako Fujita
Despite various inhibitors targeting the zinc center(s) of enzymes, drugs that target zinc fingers have not been examined in detail. We already developed a dithiol compound named SN-1 having an inhibitory effect on function of zinc finger transcription factors, but its mechanism has not been elucidated yet. For establishment of a general principle of new drugs, the detail of the action of SN-1 against a zinc finger protein was examined. As a zinc finger-containing protein, we focused on TRAF6 related to cancer and inflammation...
September 8, 2017: ChemMedChem
https://www.readbyqxmd.com/read/28884387/genome-wide-dna-methylation-patterns-in-coronary-heart-disease
#8
X Wang, A-H Liu, Z-W Jia, K Pu, K-Y Chen, H Guo
BACKGROUND: To better understand the molecular mechanisms of atherosclerosis, we conducted a comparative analysis of DNA methylation patterns in right coronary arteries in the area of advanced atherosclerotic plaques (CAP), great saphenous vein (GSV), and internal mammary artery (IMA) of patients affected by coronary heart disease. METHODS: DNA methylation data (accession number E‑GEOD-62867) were divided into three paired groups: CAP vs. IMA, CAP vs. GSV, and IMA vs...
September 7, 2017: Herz
https://www.readbyqxmd.com/read/28883651/the-role-of-transcriptional-factor-p63-in-regulation-of-epithelial-barrier-and-ciliogenesis-of-human-nasal-epithelial-cells
#9
Yakuto Kaneko, Takayuki Kohno, Takuya Kakuki, Ken-Ichi Takano, Noriko Ogasawara, Ryo Miyata, Shin Kikuchi, Takumi Konno, Tsuyoshi Ohkuni, Ryoto Yajima, Akito Kakiuchi, Shin-Ichi Yokota, Tetsuo Himi, Takashi Kojima
Disruption of nasal epithelial tight junctions (TJs) and ciliary dysfunction are found in patients with chronic rhinosinusitis (CRS) and nasal polyps (NPs), along with an increase of p63-positive basal cells and histone deacetylase (HDAC) activity. To investigate these mechanisms, primary cultures of HNECs transfected with human telomerase reverse transcriptase (hTERT-HNECs) were transfected with siRNAs of TAp63 and ΔNp63, treated with the NF-kB inhibitor curucumin and inhibitors of HDACs, and infected with respiratory syncytial virus (RSV)...
September 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28879435/anti-herpes-simplex-virus-1-and-immunomodulatory-activities-of-a-poly-%C3%AE-glutamic-acid-from-bacillus-horneckiae-strain-apa-of-shallow-vent-origin
#10
Francesca Marino-Merlo, Emanuela Papaianni, Teresa L Maugeri, Vincenzo Zammuto, Antonio Spanò, Barbara Nicolaus, Annarita Poli, Paola Di Donato, Claudia Mosca, Antonio Mastino, Concetta Gugliandolo
Herpes simplex virus type 1 (HSV-1) is responsible of common and widespread viral infections in humans through the world, and of rare, but extremely severe, clinical syndromes in the central nervous system. The emergence of resistant strains to drugs actually in use encourages the searching for novel antiviral compounds, including those of natural origin. In this study, the recently described poly-γ-glutamic acid (γ-PGA-APA), produced by the marine thermotolerant Bacillus horneckiae strain APA, and previously shown to possess biological and antiviral activity, was evaluated for its anti-HSV-1 and immunomodulatory properties...
September 7, 2017: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/28878257/molecular-mechanisms-governing-microrna-125a-expression-in-human-hepatocellular-carcinoma-cells
#11
Nicoletta Potenza, Marta Panella, Filomena Castiello, Nicola Mosca, Elena Amendola, Aniello Russo
MicroRNA-125a-5p (miR-125a) is a vertebrate homolog of lin-4, the first discovered microRNA, and plays a fundamental role in embryo development by downregulating Lin-28 protein. MiR-125a is also expressed in differentiated cells where it generally acts as an antiproliferative factor by targeting membrane receptors or intracellular transductors of mitogenic signals. MiR-125a expression is downregulated in several tumors, including hepatocellular carcinoma (HCC) where it targets sirtuin-7, matrix metalloproteinase-11, VEGF-A, Zbtb7a, and c-Raf...
September 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28877261/myelodysplastic-syndrome-patients-present-more-severe-respiratory-muscle-impairment-and-reduced-forced-vital-capacity-is-disordered-inflammatory-signaling-the-culprit
#12
Bruno Memória Okubo, Anacélia Gomes de Matos, Howard Lopes Ribeiro Junior, Daniela de Paula Borges, Roberta Taiane Germano de Oliveira, Marilena Facundo de Castro, Manoel Ricardo Alves Martins, Romélia Pinheiro Gonçalves, Pedro Felipe Carvalhedo Bruin, Ronald Feitosa Pinheiro, Silvia Maria Meira Magalhães
BACKGROUND/OBJECTIVES: The ageing process is associated with gradual decline in respiratory system performance. Anemia is highly prevalent among older adults and usually associated with adverse outcomes. Myelodysplastic syndromes (MDS) are a heterogeneous group of hematologic malignancies with increasing incidence with age and characterized by anemia and other cytopenias. The main objectives of this study were to evaluate respiratory muscle strength and lung function in elderly patients with anemia, compare data between myelodysplastic syndromes and non-clonal anemias and evaluate the influence of serum IL-8 level and NF-kB activity on deteriorate pulmonary function in this specific population...
2017: PloS One
https://www.readbyqxmd.com/read/28870958/anti-proliferative-cytotoxic-and-nf-%C3%A4-b-inhibitory-properties-of-spiro-lactone-cyclohexanone-compounds-in-human-leukemia
#13
Mustapha M Bouhenna, Barbora Orlikova, Oualid Talhi, Ben Schram, Diana C G A Pinto, Nadia Taibi, Khaldoun Bachari, Marc Diederich, Artur M S Silva, Nabil Mameri
BACKGROUND/AIM: NF-ĸB affects most aspects of cellular physiology. Deregulation of NF-ĸB signaling is associated with inflammatory diseases and cancer. In this study, we evaluated the cytotoxic and NF-ĸB inhibition potential of new spiro(lactone-cyclohexanone) compounds in two different human leukemia cell lines (U937 and K562). MATERIALS AND METHODS: The anti-proliferative effects of the spiro(lactone-cyclohexanone) compounds on human K562 and U937 cell lines was evaluated by trypan blue staining, as well as their involvement in NF-kB regulation were analyzed by luciferase reporter gene assay, Caspase-3/7 activities were evaluated to analyze apoptosis induction...
September 2017: Anticancer Research
https://www.readbyqxmd.com/read/28870864/counter-regulation-of-ecrg4-gene-expression-by-hypermethylation-dependent-inhibition-and-the-sp1-transcription-factor-dependent-stimulation-of-the-c2orf40-promoter
#14
Xitong Dang, Xiaorong Zeng, Raul Coimbra, Brian P Eliceiri, Andrew Baird
The human cytokine precursor ECRG4 has been associated with multiple physiological, developmental and pathophysiological processes involving cell proliferation, cell migration, innate immunity, inflammation, cancer progression and metastases. Although down-regulation of ECRG4 gene expression has been largely attributed to hypermethylation of CpG islands in the 5'untranslated region of the ECRG4 promoter, the mechanisms that underlie the dynamics of its regulation have never been systematically described. Here we show that the ECRG4 gene is widely expressed in human tissues and report that its core promoter lies between the -780 to +420 base pairs relative to the ATG start codon of the ECRG4 open reading frame...
September 1, 2017: Gene
https://www.readbyqxmd.com/read/28868036/baicalin-alleviates-lipopolysaccharide-induced-liver-inflammation-in-chicken-by-suppressing-tlr4-mediated-nf-%C3%AE%C2%BAb-pathway
#15
Ping Cheng, Tong Wang, Wei Li, Ishfaq Muhammad, He Wang, Xiaoqi Sun, Yuqi Yang, Jiarui Li, Tianshi Xiao, Xiuying Zhang
As a kind of potent stimulus, lipopolysaccharide (LPS) has the ability to cause cell damage by activating toll-like receptor(TLR)4, then nuclear factor kappa B (NF-κB) translocates into the nucleus and changes the expression of related inflammatory genes. Baicalin is extracted from Radix Scutellariae, which possesses anti-inflammation, antioxidant and antibacterial properties. However, the effects of it on LPS-induced liver inflammation have not been fully elucidated. This study aims to investigate the anti-inflammatory effects of Baicalin on the LPS-induced liver inflammation and its underlying molecular mechanisms in chicken...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28865453/arginine-vasopressin-altered-the-expression-of-monocarboxylate-transporters-in-cultured-astrocytes-isolated-from-stroke-prone-spontaneously-hypertensive-rats-and-congenic-shrpch1_18-rats
#16
Kazuo Yamagata, Natsumi Takahashi, Nozomi Akita, Toru Nabika
BACKGROUND: Astrocytes support a range of brain functions as well as neuronal survival, but their detailed relationship with stroke-related edema is not well understood. We previously demonstrated that the release of lactate from astrocytes isolated from stroke-prone spontaneously hypertensive rats (SHRSP/Izm) was attenuated under stroke conditions. The supply of lactate to neurons is regulated by astrocytic monocarboxylate transporters (MCTs). The purpose of this study was to examine the contributions of arginine vasopressin (AVP) and/or hypoxia and reoxygenation (H/R) to the regulation of MCTs and neurotrophic factor in astrocytes obtained from SHRSP/Izm and congenic SHRpch1_18 rats...
September 2, 2017: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/28865081/chronic-treatment-with-zoledronic-acid-increases-inflammatory-markers-in-periodontium-of-rats
#17
Paulo Goberlânio de Barros Silva, Antonio Ernando Carlos Ferreira Junior, Camila Carvalho de Oliveira, Luiz André Cavalcante Brizeno, Deysi Viviana Tenazoa Wong, Roberto César Pereira Lima Júnior, Fabrício Bitú Sousa, Mário Rogério Lima Mota, Ana Paula Negreiros Nunes Alves
BACKGROUND: Bisphosphonates (BF) rises proinflammatory markers and irreversibly binds to bone. Chronically BF can lead to an inflammatory status and can increase the local oxidative stress in periodontium. Therefore, the objective of this study was evaluated if the chronic infusion of Zoledronic Acid (ZA) increases inflammatory markers in periodontium of rats. METHODS AND RESULTS: Chronically infusion therapy was performed with ZA (0.04, 0.2 or 1 mg/kg or saline) by four doses in over a 70-day period to analysis periodontium of the first right inferior molar using histologic, histochemical (toluidine blue) and immunohistochemical (CD68, Tumor Necrosis Factor-α (TNF-α), Interleukin-1beta (IL-1β), Inducible Nitric Oxide Synthase (iNOS) and Nuclear Factor kappa B (NF-kB)) tests...
September 2, 2017: Journal of Oral Pathology & Medicine
https://www.readbyqxmd.com/read/28864290/bone-marrow-derived-mesenchymal-stem-cells-regress-aortic-aneurysm-via-the-nf-kb-smad3-and-akt-signaling-pathways
#18
Aika Yamawaki-Ogata, Hideki Oshima, Akihiko Usui, Yuji Narita
BACKGROUND AIMS: We have confirmed that aortic aneurysm (AA) can be regressed by the administration of bone marrow-derived mesenchymal stem cells (BM-MSCs). We investigated the kinetics of signaling pathways in AA following treatment with BM-MSCs. METHODS: Angiotensin II-infused apolipoprotein E-deficient mice were treated by intravenous injection of 1 × 10(6) BM-MSCs in 0.2 mL saline (BM-MSCs group, n = 5) or 0.2 mL saline (saline group, n = 5)...
August 30, 2017: Cytotherapy
https://www.readbyqxmd.com/read/28860341/targeting-metabolism-and-survival-in-chronic-lymphocytic-leukemia-and-richter-syndrome-cells-by-a-novel-nf-kb-inhibitor
#19
Tiziana Vaisitti, Federica Gaudino, Samedy Ouk, Maria Moscvin, Nicoletta Vitale, Sara Serra, Francesca Arruga, Johannes L Zakrzewski, Hsiou-Chi Liou, John N Allan, Richard R Furman, Silvia Deaglio
IT-901 is a novel and selective NF-kB inhibitor with promising activity in pre-clinical models. Here we show that treatment of chronic lymphocytic leukemia cells with IT-901 effectively interrupts NF-kB transcriptional activity. Chronic lymphocytic leukemia cells exposed to the drug display elevated mitochondrial reactive oxygen species, which damage mitochondria, limit oxidative phosphorylation and ATP production and activate intrinsic apoptosis. Inhibition of NF-kB signaling in stromal and myeloid cells, both tumor-supportive elements, fails to induce apoptosis, but impairs NF-kB-driven expression of molecules involved in cell-cell contacts and immune responses, essential elements in creating a pro-leukemic niche...
August 31, 2017: Haematologica
https://www.readbyqxmd.com/read/28860004/lox-1-a-potential-target-for-therapy-in-atherosclerosis-an-in-vitro-study
#20
Albina Arjuman, Nimai C Chandra
Pro-inflammatory signal generated from the interaction of oxLDL with its cognate receptor LOX-1 has been attenuated successfully by a novel combination siRNA (siLOX-1(Ω)) targeting unique regions of Homo sapien LOX-1 mRNA. Signalling via LOX-1R was studied in a potentially pro-atherogenic arena recreated in a metabolic, pulse-chase set up. An initial pulse of oxLDL (20μg/mL;5h) was chased (without oxLDL) on a temporal scale upto 72h. Our study shows that the pro-inflammatory signal generated via oxLDL-LOX-1R interaction was mediated in two rungs, an initial sustained increase in LOX-1R expression up to 12h, and a renewal after 48h...
August 30, 2017: International Journal of Biochemistry & Cell Biology
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