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https://www.readbyqxmd.com/read/28917650/dodecyl-sorbitan-ethers-as-antimicrobials-against-gram-positive-bacteria
#1
Dorine Belmessieri, Charlotte Gozlan, Marie-Christine Duclos, Oana Dumitrescu, Gérard Lina, Andreas Redl, Nicolas Duguet, Marc Lemaire
A range of amphiphilic sorbitan ethers has been synthesized in two steps from sorbitan following an acetalization/hydrogenolysis sequence. These sorbitan ethers and the acetal intermediates have been evaluated as antimicrobials against Gram-negative and Gram-positive bacteria. No antimicrobial activity was observed for Gram-negative bacteria. However, the compounds bearing a linear dodecyl chain exhibit antimicrobial activity (MIC as low as 8μg/mL) against Gram-positive bacteria such as Listeria monocytogenes, Enterococcus faecalis and Staphylococcus aureus...
September 7, 2017: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/28917531/hollow-microneedle-mediated-intradermal-delivery-of-model-vaccine-antigen-loaded-plga-nanoparticles-elicits-protective-t-cell-mediated-immunity-to-an-intracellular-bacterium
#2
Anne Marit de Groot, Guangsheng Du, Juha Mönkäre, Anouk C M Platteel, Femke Broere, Joke A Bouwstra, Alice J A M Sijts
The skin is an attractive organ for immunization due to the presence of a large number of epidermal and dermal antigen-presenting cells. Hollow microneedles allow for precise and non-invasive intradermal delivery of vaccines. In this study, ovalbumin (OVA)-loaded poly(lactic-co-glycolic acid) (PLGA) nanoparticles with and without TLR3 agonist poly(I:C) were prepared and administered intradermally by hollow microneedles. The capacity of the PLGA nanoparticles to induce a cytotoxic T cell response, contributing to protection against intracellular pathogens, was examined...
September 13, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/28916475/deletion-of-nadh-oxidase-in-listeria-monocytogenes-promotes-the-bacterial-infection-of-brain
#3
Sen Li, Wenwen Yu, Xiao Guan, Zhen Luo, Guowei Chen, Wukang Liu, Jingchen Zhang
NADH oxidase (NOX) plays important roles in respiration and reactive oxygen species (ROS) generation in cells. In this study, we explored the function of NOX in Listeria monocytogenes by gene deletion. From our results, nox mutant strain (∆nox) had lower H2O2 level and showed no significant alteration in bacteria growth activity. But it had enhanced invasiveness during the invasion of glial cells and mice brain compared to wildtype strain. Furthermore, several virulence genes involved in invasion, such as inlA, inlB, vip and sigB, were upregulated in ∆nox, and the alterations could be restored by complementation...
September 12, 2017: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/28914098/the-antimicrobial-effects-of-three-phenolic-extracts-from-rosmarinus-officinalis-l-vitis-vinifera-l-and-polygonum-cuspidatum-l-on-food-pathogens
#4
Francesca Santomauro, Cristiana Sacco, Rosa Donato, Maria Bellumori, Marzia Innocenti, Nadia Mulinacci
In this study three phenolic extracts were examined, without volatile fraction, against common food pathogens. The samples, all suitable for food application, were from the leaves of Rosmarinus officinalis L., Vitis vinifera L., and the root of Polygonum cuspidatum L. The microorganisms tested were Escherichia coli O157:H7, Salmonella Enteritidis, Salmonella Typhi, Yersinia enterocolitica and Listeria monocytogenes, well-known as important food pathogens. The results demonstrated a microbicidal activity of all the tested compounds at different concentrations; the rosemary extract showed greater efficacy than the other compounds against the tested microorganisms...
September 15, 2017: Natural Product Research
https://www.readbyqxmd.com/read/28912764/resistance-to-antibiotics-biocides-preservatives-and-metals-in-bacteria-isolated-from-seafoods-co-selection-of-strains-resistant-or-tolerant-to-different-classes-of-compounds
#5
José L Romero, María J Grande Burgos, Rubén Pérez-Pulido, Antonio Gálvez, Rosario Lucas
Multi-drug resistant bacteria (particularly those producing extended-spectrum β-lactamases) have become a major health concern. The continued exposure to antibiotics, biocides, chemical preservatives, and metals in different settings such as the food chain or in the environment may result in development of multiple resistance or co-resistance. The aim of the present study was to determine multiple resistances (biocides, antibiotics, chemical preservatives, phenolic compounds, and metals) in bacterial isolates from seafoods...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28912268/structural-and-functional-diversity-in-listeria-cell-wall-teichoic-acids
#6
Yang Shen, Samy Boulos, Eric Sumrall, Benjamin Gerber, Alicia Julian-Rodero, Marcel R Eugster, Lars Fieseler, Laura Nyström, Marc-Olivier Ebert, Martin J Loessner
Wall teichoic acids (WTAs) are the most abundant glycopolymers found on the cell wall of many Gram-positive bacteria, whose diverse surface structures play key roles in multiple biological processes. Despite recent technological advances in glycan analysis, structural elucidation of WTAs remains challenging due to their complex nature. Here, we employed a combination of UPLC-MS/MS and NMR to determine the structural complexity of WTAs from Listeria species. We unveiled more than 10 different types of WTA polymers that vary in their linkage and repeating units...
September 14, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28910155/identification-of-the-molecular-mechanism-of-trimethoprim-resistance-in-listeria-monocytogenes
#7
Dorota Korsak, Agata Krawczyk-Balska
Trimethoprim with sulfamethoxazole is a therapeutic agent combination used to treat infections caused by the facultative intracellular foodborne pathogen Listeria monocytogenes. The aim of this study was to assess the frequency of resistance of L. monocytogenes arising due to exposure to trimethoprim and subsequently investigate the molecular mechanisms of resistance. After exposure of a culture of L. monocytogenes ATCC 13932 to trimethoprim at 10-fold the minimal inhibitory concentration spontaneous resistant mutants were recovered, giving a frequency of resistance development of 6...
September 14, 2017: Foodborne Pathogens and Disease
https://www.readbyqxmd.com/read/28910141/rapid-screening-of-natural-plant-extracts-with-calcium-diacetate-for-differential-effects-against-foodborne-pathogens-and-a-probiotic-bacterium
#8
William Colonna, Byron Brehm-Stecher, Kalidas Shetty, Anthony Pometto Iii
This study focused on advancing a rapid turbidimetric bioassay to screen antimicrobials using specific cocktails of targeted foodborne bacterial pathogens. Specifically, to show the relevance of this rapid screening tool, the antimicrobial potential of generally recognized as safe calcium diacetate (DAX) and blends with cranberry (NC) and oregano (OX) natural extracts was evaluated. Furthermore, the same extracts were evaluated against beneficial lactic acid bacteria. The targeted foodborne pathogens evaluated were Escherichia coli O157:H7, Salmonella spp...
September 14, 2017: Foodborne Pathogens and Disease
https://www.readbyqxmd.com/read/28904870/membrane-dynamics-of-resting-and-internalin-b-bound-met-receptor-tyrosine-kinase-studied-by-single-molecule-tracking
#9
Marie-Lena I E Harwardt, Phoebe Young, Willem M Bleymüller, Timo Meyer, Christos Karathanasis, Hartmut H Niemann, Mike Heilemann, Marina S Dietz
The human MET receptor tyrosine kinase contributes to vertebrate development and cell proliferation. As a proto-oncogene, it is a target in cancer therapies. MET is also relevant for bacterial infection by Listeria monocytogenes and is activated by the bacterial protein internalin B. The processes of ligand binding, receptor activation, and the diffusion behavior of MET within the plasma membrane as well as its interconnections with various cell components are not fully understood. We investigated the receptor diffusion dynamics using single-particle tracking and imaging fluorescence correlation spectroscopy and elucidated mobility states of resting and internalin B-bound MET...
September 2017: FEBS Open Bio
https://www.readbyqxmd.com/read/28903832/validation-of-modifications-to-the-ansr-for-listeria-method-for-improved-internal-positive-control-performance
#10
Susan Alles, Evan Meister, Edan Hosking, Eric Tovar, Rebecca Shaulis, Mark Schonfeld, Lei Zhang, Lin Li, Preetha Biswas, Mark Mozola, Robert Donofrio
A study was conducted to validate a minor reagent formulation change to the ANSR for Listeria method, Performance Tested Method(SM) 101202. This change involves increasing the master mix volume prelyophilization by 40% and addition of salmon sperm DNA (nontarget DNA) to the master mix. These changes improve the robustness of the internal positive control response and reduce the possibility of obtaining invalid results due to weak-positive control curves. When three foods (hot dogs, Mexican-style cheese, and cantaloupe) and sponge samples taken from a stainless steel surface were tested, no significant differences in performance between the ANSR and U...
September 14, 2017: Journal of AOAC International
https://www.readbyqxmd.com/read/28903313/snx10-promotes-phagosome-maturation-in-macrophages-and-protects-mice-against-listeria-monocytogenes-infection
#11
Jun Lou, Xiawei Li, Wei Huang, Jingjing Liang, Mingzhu Zheng, Ting Xu, Jun Lyu, Dan Li, Qin Xu, Xuexiao Jin, Guotong Fu, Di Wang, Linrong Lu
Listeria monocytogenes (L. monocytogenes), which is a facultative intracellular bacterial pathogen that causes listeriosis, is widely used to study the mammalian immune response to infection. After phagocytosis by professional phagocytes, L. monocytogenes is initially contained within phagosomes, which mature into phagolysosomes, where the bacteria are degraded. Although phagocytosis and subsequent phagosome maturation is essential for the clearance of infectious microbial pathogens, the underlying regulatory mechanisms are still unclear...
August 15, 2017: Oncotarget
https://www.readbyqxmd.com/read/28903312/gnp-gapdh1-22-nanovaccines-prevent-neonatal-listeriosis-by-blocking-microglial-apoptosis-and-bacterial-dissemination
#12
Ricardo Calderon-Gonzalez, Elisabet Frande-Cabanes, Hector Teran-Navarro, José María Marimon, Javier Freire, David Salcines-Cuevas, M Carmen Fariñas, Claudia Onzalez-Rico, Marco Marradi, Isabel Garcia, Mirian Alkorta-Gurrutxaga, Aida San Nicolas-Gomez, Ana Castañeda-Sampedro, Sonsoles Yañez-Diaz, Soledad Penades, Carmen Punzon, Javier Gomez-Roman, Fernando Rivera, Manuel Fresno, Carmen Alvarez-Dominguez
Clinical cases of neonatal listeriosis are associated with brain disease and fetal loss due to complications in early or late pregnancy, which suggests that microglial function is altered. This is believed to be the first study to link microglial apoptosis with neonatal listeriosis and listeriosis-associated brain disease, and to propose a new nanovaccine formulation that reverses all effects of listeriosis and confers Listeria monocytogenes (LM)-specific immunity. We examined clinical cases of neonatal listeriosis in 2013-2015 and defined two useful prognostic immune biomarkers to design listeriosis vaccines: high anti-GAPDH1-22 titres and tumor necrosis factor (TNF)/interleukin (IL)-6 ratios...
August 15, 2017: Oncotarget
https://www.readbyqxmd.com/read/28900418/lmof2365_0442-encoding-for-a-fructose-specific-pts-permease-iia-may-be-required-for-virulence-in-l-monocytogenes-strain-f2365
#13
Yanhong Liu, Brian B Yoo, Cheng-An Hwang, Yujuan Suo, Shiowshuh Sheen, Parvaneh Khosravi, Lihan Huang
Listeria monocytogenes is a foodborne pathogen that causes listeriosis, which is a major public health concern due to the high fatality rate. LMOf2365_0442, 0443, and 0444 encode for fructose-specific EIIABC components of phosphotransferase transport system (PTS) permease that is responsible for sugar transport. In previous studies, in-frame deletion mutants of a putative fructose-specific PTS permease (LMOf2365_0442, 0443, and 0444) were constructed and analyzed. However, the virulence potential of these deletion mutants has not been studied...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28898264/assessment-of-listeria-monocytogenes-virulence-in-the-galleria-mellonella-insect-larvae-model
#14
Mira Rakic Martinez, Martin Wiedmann, Martine Ferguson, Atin R Datta
Several animal models have been used to understand the molecular basis of the pathogenicity, infectious dose and strain to strain variation of Listeria monocytogenes. The greater wax worm Galleria mellonella, as an alternative model, provides some useful advantages not available with other models and has already been described as suitable for the virulence assessment of various pathogens including L. monocytogenes. The objectives of this study are: 1) confirming the usefulness of this model with a wide panel of Listeria spp...
2017: PloS One
https://www.readbyqxmd.com/read/28894104/nfatc1-controls-the-cytotoxicity-of-cd8-t-cells
#15
Stefan Klein-Hessling, Khalid Muhammad, Matthias Klein, Tobias Pusch, Ronald Rudolf, Jessica Flöter, Musga Qureischi, Andreas Beilhack, Martin Vaeth, Carsten Kummerow, Christian Backes, Rouven Schoppmeyer, Ulrike Hahn, Markus Hoth, Tobias Bopp, Friederike Berberich-Siebelt, Amiya Patra, Andris Avots, Nora Müller, Almut Schulze, Edgar Serfling
Cytotoxic T lymphocytes are effector CD8(+) T cells that eradicate infected and malignant cells. Here we show that the transcription factor NFATc1 controls the cytotoxicity of mouse cytotoxic T lymphocytes. Activation of Nfatc1 (-/-) cytotoxic T lymphocytes showed a defective cytoskeleton organization and recruitment of cytosolic organelles to immunological synapses. These cells have reduced cytotoxicity against tumor cells, and mice with NFATc1-deficient T cells are defective in controlling Listeria infection...
September 11, 2017: Nature Communications
https://www.readbyqxmd.com/read/28892017/biodiversity-of-actinobacteria-from-the-south-pacific-and-the-assessment-of-streptomyces-chemical-diversity-with-metabolic-profiling
#16
Andrés Cumsille, Agustina Undabarrena, Valentina González, Fernanda Claverías, Claudia Rojas, Beatriz Cámara
Recently, bioprospecting in underexplored habitats has gained enhanced focus, since new taxa of marine actinobacteria can be found, and thus possible new metabolites. Actinobacteria are in the foreground due to their versatile production of secondary metabolites that present various biological activities, such as antibacterials, antitumorals and antifungals. Chilean marine ecosystems remain largely unexplored and may represent an important source for the discovery of bioactive compounds. Various culture conditions to enrich the growth of this phylum were used and 232 bacterial strains were isolated...
September 11, 2017: Marine Drugs
https://www.readbyqxmd.com/read/28889054/evaluation-of-chemical-immersion-treatments-to-reduce-microbial-populations-in-fresh-beef
#17
Ahmed Kassem, Joseph Meade, James Gibbons, Kevina McGill, Ciara Walsh, James Lyng, Paul Whyte
The aim of the current study was to assess the ability of a number of chemicals (acetic Acid (AA), citric acid (CA) lactic acid (LA), sodium decanoate (SD) and trisodium phosphate (TSP)) to reduce microbial populations (total viable count, Campylobacter jejuni, Escherichia coli, Salmonella typhimurium and Listeria monocytogenes) on raw beef using an immersion system. The following concentrations of each chemical were used: 3 & 5% for AA, CA, LA, SD and 10 &12% for TSP. Possible synergistic effects of using combinations of two chemicals sequentially (LA+CA and LA+AA) were also investigated...
September 5, 2017: International Journal of Food Microbiology
https://www.readbyqxmd.com/read/28888657/spontaneous-listeriosis-in-grey-mouse-lemurs-microcebus-murinus-but-not-in-goodman-s-mouse-lemurs-microcebus-lehilahytsara-of-the-same-colony
#18
Kirsten Hülskötter, Daniel Schmidtke, Marko Dubicanac, Ute Siesenop, Elke Zimmermann, Ingo Gerhauser, Wolfgang Baumgärtner, Vanessa Herder
Listeriosis is a zoonotic infection with the gram positive, facultative intracellular bacterium Listeria (L.) monocytogenes. Infections mainly occur in ruminants, but also in other species, including humans. Case fatality rate usually is high. The incidence of listeriosis in captive non-human primates is very low. We report the first spontaneous, fatal, and likely food-born outbreak of listeriosis in a population of captive grey mouse lemurs (Microcebus murinus). Conspicuously, none of the closely related Goodman's mouse lemurs (Microcebus lehilahytsara) in the same facility were affected...
September 2017: Veterinary Microbiology
https://www.readbyqxmd.com/read/28888628/neuropathological-survey-reveals-underestimation-of-the-prevalence-of-neuroinfectious-diseases-in-cattle-in-switzerland
#19
Laura Truchet, Julia Walland, Daniel Wüthrich, Céline L Boujon, Horst Posthaus, Rémy Bruggmann, Gertraud Schüpbach-Regula, Anna Oevermann, Torsten Seuberlich
Neuroinfectious diseases in livestock represent a severe threat to animal health, but their prevalence is not well documented and the etiology of disease often remains unidentified. The aims of this study were to generate baseline data on the prevalence of neuroinfectious diseases in cattle in Switzerland by neuropathological survey, and to identify disease-associated pathogens. The survey was performed over a 1-year period using a representative number of brainstem samples (n=1816) from fallen cattle. In total, 4% (n=73) of the animals had significant lesions, the most frequent types of which were indicative of viral (n=27) and bacterial (n=31) etiologies...
September 2017: Veterinary Microbiology
https://www.readbyqxmd.com/read/28888435/resuscitation-and-growth-kinetics-of-sub-lethally-injured-listeria-monocytogenes-strains-following-fluorescence-activated-cell-sorting-facs
#20
Thulani Sibanda, Elna M Buys
This study investigated the effect of acid (pH4.2), osmotic (10% NaCl) and heat (55°C for 30min) stress induced injury on Listeria monocytogenes strains ATCC19115, 69, 159/10 and 243 using differential plating and flow cytometry coupled with membrane integrity indicators, thiazole orange (TO) and propidium iodide (PI) staining. Growth kinetics of injured cells sorted by fluorescence activated cell sorting (FACS) were studied at 4, 25 and 37°C. The percentage of cell injury detectable by both flow cytometry and differential plating varied significantly among strains and stress treatments (p<0...
October 2017: Food Research International
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