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https://www.readbyqxmd.com/read/28492905/screening-for-thyroid-cancer-us-preventive-services-task-force-recommendation-statement
#1
Kirsten Bibbins-Domingo, David C Grossman, Susan J Curry, Michael J Barry, Karina W Davidson, Chyke A Doubeni, John W Epling, Alex R Kemper, Alex H Krist, Ann E Kurth, C Seth Landefeld, Carol M Mangione, Maureen G Phipps, Michael Silverstein, Melissa A Simon, Albert L Siu, Chien-Wen Tseng
Importance: The incidence of thyroid cancer detection has increased by 4.5% per year over the last 10 years, faster than for any other cancer, but without a corresponding change in the mortality rate. In 2013, the incidence rate of thyroid cancer in the United States was 15.3 cases per 100 000 persons. Most cases of thyroid cancer have a good prognosis; the 5-year survival rate for thyroid cancer overall is 98.1%. Objective: To update the US Preventive Services Task Force (USPSTF) recommendation on screening for thyroid cancer...
May 9, 2017: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/28453410/does-lymphedema-severity-affect-quality-of-life-simple-question-challenging-answers
#2
Teresa S Lee, Carol M Morris, Sharon A Czerniec, Andrea J Mangion
PURPOSE: Lymphedema can have a negative impact on the function and quality of life (QOL) of patients, but most studies have examined lymphedema as a binary variable, rather than a multidimensional disease that ranges in severity. This study explored the potential impact of lymphedema severity on function and overall QOL. METHODS AND RESULTS: Of the 54 lymphedema patients recruited, 40 reported their most severe swelling to be in a limb. These participants underwent bioimpedance measurement (L-Dex(®)) and completed either the disabilities of the arm, shoulder, and hand (DASH) questionnaire or the lower extremity functional scale (LEFS)...
April 28, 2017: Lymphatic Research and Biology
https://www.readbyqxmd.com/read/28444455/prevalence-predictors-and-prognostic-implications-of-residual-impairment-of-functional-capacity-after-transcatheter-aortic-valve-implantation
#3
Mohammad Abdelghani, Rafael Cavalcante, Yosuke Miyazaki, Robbert J de Winter, Rogério Sarmento-Leite, José A Mangione, Alexandre Abizaid, Pedro A Lemos, Patrick W Serruys, Fabio S de Brito
BACKGROUND: Patients with degenerative aortic stenosis (AS) referred for transcatheter aortic valve implantation (TAVI) typically have advanced cardiac and vascular adverse remodeling and multiple comorbidities and, therefore, might not recover a normal functional capacity after valve replacement. We sought to investigate the prevalence, the predictors, and the prognostic impact of residual impairment of functional capacity after TAVI. METHODS AND RESULTS: Out of 790 patients undergoing TAVI with impaired functional capacity (NYHA II-IV) at baseline, NYHA functional class improved in 592 (86...
April 25, 2017: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
https://www.readbyqxmd.com/read/28444286/screening-for-preeclampsia-us-preventive-services-task-force-recommendation-statement
#4
Kirsten Bibbins-Domingo, David C Grossman, Susan J Curry, Michael J Barry, Karina W Davidson, Chyke A Doubeni, John W Epling, Alex R Kemper, Alex H Krist, Ann E Kurth, C Seth Landefeld, Carol M Mangione, William R Phillips, Maureen G Phipps, Michael Silverstein, Melissa A Simon, Chien-Wen Tseng
Importance: Preeclampsia affects approximately 4% of pregnancies in the United States. It is the second leading cause of maternal mortality worldwide and may lead to serious maternal complications, including stroke, eclampsia, and organ failure. Adverse perinatal outcomes for the fetus and newborn include intrauterine growth restriction, low birth weight, and stillbirth. Many of the complications associated with preeclampsia lead to early induction of labor or cesarean delivery and subsequent preterm birth...
April 25, 2017: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/28434325/antiamyloidogenic-and-proamyloidogenic-chaperone-effects-of-c-reactive-protein-and-serum-amyloid-p-component
#5
Daisaku Ozawa, Ryo Nomura, P Patrizia Mangione, Kazuhiro Hasegawa, Tadakazu Okoshi, Riccardo Porcari, Vittorio Bellotti, Hironobu Naiki
No abstract text is available yet for this article.
March 2017: Amyloid: the International Journal of Experimental and Clinical Investigation
https://www.readbyqxmd.com/read/28429761/a-specific-nanobody-prevents-amyloidogenesis-of-d76n-%C3%AE-2-microglobulin-in-vitro-and-modifies-its-tissue-distribution-in-vivo
#6
Sara Raimondi, Riccardo Porcari, P Patrizia Mangione, Guglielmo Verona, Julien Marcoux, Sofia Giorgetti, Graham W Taylor, Stephan Ellmerich, Maurizio Ballico, Stefano Zanini, Els Pardon, Raya Al-Shawi, J Paul Simons, Alessandra Corazza, Federico Fogolari, Manuela Leri, Massimo Stefani, Monica Bucciantini, Julian D Gillmore, Philip N Hawkins, Maurizia Valli, Monica Stoppini, Carol V Robinson, Jan Steyaert, Gennaro Esposito, Vittorio Bellotti
Systemic amyloidosis is caused by misfolding and aggregation of globular proteins in vivo for which effective treatments are urgently needed. Inhibition of protein self-aggregation represents an attractive therapeutic strategy. Studies on the amyloidogenic variant of β2-microglobulin, D76N, causing hereditary systemic amyloidosis, have become particularly relevant since fibrils are formed in vitro in physiologically relevant conditions. Here we compare the potency of two previously described inhibitors of wild type β2-microglobulin fibrillogenesis, doxycycline and single domain antibodies (nanobodies)...
April 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28424217/use-of-life-jackets-and-other-types-of-flotation-for-in-water-recreation-in-designated-swim-areas-in-washington-state
#7
Linda Quan, Thomas Mangione, Elizabeth Bennett, Wendy Chow
Most fatal drownings worldwide occur in open water. Flotation devices may protect swimmers. Their use by those recreating in water has not been described. METHODS: Observational survey of swimmers and waders at designated swim sites at lakes and rivers evaluated them by age group, sex, type of flotation used (life jacket vs substandard flotation, eg, water wings, noodles, inflatables) and, for children <6 years, being within arm's reach of an adult. RESULTS: Of 1967 swimmers/waders observed, 37% used some type of flotation device...
April 19, 2017: Injury Prevention: Journal of the International Society for Child and Adolescent Injury Prevention
https://www.readbyqxmd.com/read/28392314/persistence-and-proliferation-of-human-mesenchymal-stromal-cells-in-the-right-ventricular-myocardium-after-intracoronary-injection-in-a-large-animal-model-of-pulmonary-hypertension
#8
Roza Badr Eslam, Kevin Croce, Fernanda Marinho Mangione, Robert Musmann, Jane A Leopold, Richard N Mitchell, Aaron B Waxman
BACKGROUND AIMS: In this study, we demonstrate long-term persistence of human mesenchymal stromal cells (hMSCs) after intracoronary injection in a large animal model of pulmonary hypertension (PH). METHODS: Commercially available placenta-derived hMSCs were used. Experiments were conducted on 14 female Yorkshire swine. Four animals served as controls, and 10 underwent pulmonary vein (PV) banding. After 12 ± 2 weeks, PH and PV dysfunction were confirmed by right heart catheterization and cardiac magnetic resonance imaging...
April 6, 2017: Cytotherapy
https://www.readbyqxmd.com/read/28391703/a-cluster-randomized-controlled-trial-of-the-myfamilyplan-online-preconception-health-education-tool
#9
Priya Batra, Carol M Mangione, Eric Cheng, W Neil Steers, Tina A Nguyen, Douglas Bell, Alice A Kuo, Kimberly D Gregory
PURPOSE: To evaluate whether exposure to MyFamilyPlan-a web-based preconception health education module-changes the proportion of women discussing reproductive health with providers at well-woman visits. DESIGN: Cluster randomized controlled trial. One hundred thirty participants per arm distributed among 34 clusters (physicians) required to detect a 20% change in the primary outcome. SETTING: Urban academic medical center (California). PARTICIPANTS: Eligible women were 18 to 45 years old, were English speaking, were nonpregnant, were able to access the Internet, and had an upcoming well-woman visit...
January 1, 2017: American Journal of Health Promotion: AJHP
https://www.readbyqxmd.com/read/28388383/when-the-tail-wags-the-dog-clinical-skills-in-the-age-of-technology
#10
EDITORIAL
Salvatore Mangione
No abstract text is available yet for this article.
April 2017: Cleveland Clinic Journal of Medicine
https://www.readbyqxmd.com/read/28373108/development-and-implementation-of-the-family-experiences-with-coordination-of-care-survey-quality-measures
#11
Courtney Gidengil, Layla Parast, Q Burkhart, Julie Brown, Marc N Elliott, K Casey Lion, Elizabeth A McGlynn, Eric C Schneider, Rita Mangione-Smith
OBJECTIVE: Ensuring high-quality care coordination for children with medical complexity (CMC) could yield significant health and economic benefits because they account for one-third of pediatric health care expenditures. The objective of this study was to develop and field test the Family Experiences with Coordination of Care (FECC) survey, which facilitates assessment of 20 new caregiver-reported quality measures for CMC. METHODS: We identified caregivers of Medicaid-insured CMC aged 0 to 17 years in Minnesota and Washington state, categorized by the Pediatric Medical Complexity Algorithm as having complex chronic disease...
March 31, 2017: Academic Pediatrics
https://www.readbyqxmd.com/read/28364045/diagnostic-accuracy-of-3-0-t-magnetic-resonance-t1-and-t2-mapping-and-t2-weighted-dark-blood-imaging-for-the-infarct-related-coronary-artery-in-non-st-segment-elevation-myocardial-infarction
#12
Jamie Layland, Samuli Rauhalammi, Matthew M Y Lee, Nadeem Ahmed, Jaclyn Carberry, Vannesa Teng Yue May, Stuart Watkins, Christie McComb, Kenneth Mangion, John D McClure, David Carrick, Anna O'Donnell, Arvind Sood, Margaret McEntegart, Keith G Oldroyd, Aleksandra Radjenovic, Colin Berry
BACKGROUND: Patients with recent non-ST-segment elevation myocardial infarction commonly have heterogeneous characteristics that may be challenging to assess clinically. METHODS AND RESULTS: We prospectively studied the diagnostic accuracy of 2 novel (T1, T2 mapping) and 1 established (T2-weighted short tau inversion recovery [T2W-STIR]) magnetic resonance imaging methods for imaging the ischemic area at risk and myocardial salvage in 73 patients with non-ST-segment elevation myocardial infarction (mean age 57±10 years, 78% male) at 3...
March 31, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28350936/screening-for-celiac-disease-us-preventive-services-task-force-recommendation-statement
#13
Kirsten Bibbins-Domingo, David C Grossman, Susan J Curry, Michael J Barry, Karina W Davidson, Chyke A Doubeni, Mark Ebell, John W Epling, Jessica Herzstein, Alex R Kemper, Alex H Krist, Ann E Kurth, C Seth Landefeld, Carol M Mangione, Maureen G Phipps, Michael Silverstein, Melissa A Simon, Chien-Wen Tseng
Importance: Celiac disease is caused by an immune response in persons who are genetically susceptible to dietary gluten, a protein complex found in wheat, rye, and barley. Ingestion of gluten by persons with celiac disease causes immune-mediated inflammatory damage to the small intestine. Objective: To issue a new US Preventive Services Task Force (USPSTF) recommendation on screening for celiac disease. Evidence Review: The USPSTF reviewed the evidence on the accuracy of screening in asymptomatic adults, adolescents, and children; the potential benefits and harms of screening vs not screening and targeted vs universal screening; and the benefits and harms of treatment of screen-detected celiac disease...
March 28, 2017: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/28346590/implementation-and-evaluation-of-a-large-scale-teleretinal-diabetic-retinopathy-screening-program-in-the-los-angeles-county-department-of-health-services
#14
Lauren P Daskivich, Carolina Vasquez, Carlos Martinez, Chi-Hong Tseng, Carol M Mangione
Importance: Diabetic retinopathy (DR) is the leading cause of blindness in adults of working age in the United States. In the Los Angeles County safety net, a nonvertically integrated system serving underinsured and uninsured patients, the prevalence of DR is approximately 50%, and owing to limited specialty care resources, the average wait times for screening for DR have been 8 months or more. Objective: To determine whether a primary care-based teleretinal DR screening (TDRS) program reduces wait times for screening and improves timeliness of needed care in the Los Angeles County safety net...
May 1, 2017: JAMA Internal Medicine
https://www.readbyqxmd.com/read/28302347/fungemia-due-to-saprochaete-capitata-in-a-non-neutropenic-patient-hospitalized-in-an-intensive-care-unit-after-cardiac-surgery
#15
C Cavanna, F Lallitto, F Mangione, F Tamarozzi, P Marone, P Ceriana
The majority of invasive fungal infections observed in non-neutropenic patients hospitalized in an intensive care unit are caused by Candida spp and current guidelines recommend echinocandins as the first-line treatment. Fungemias caused by filamentous or arthrosporic fungi such as Saprochaete capitata (previously named Geotrichum capitatum) are extremely rare. In fact, invasive infections due to S. capitata have been reported almost exclusively in neutropenic oncohematological patients. In this report, we describe a case of fungemia caused by S...
March 14, 2017: Journal de Mycologie Médicale
https://www.readbyqxmd.com/read/28298647/inhibition-of-the-mechano-enzymatic-amyloidogenesis-of-transthyretin-role-of-ligand-affinity-binding-cooperativity-and-occupancy-of-the-inner-channel
#16
Guglielmo Verona, P Patrizia Mangione, Sara Raimondi, Sofia Giorgetti, Giulia Faravelli, Riccardo Porcari, Alessandra Corazza, Julian D Gillmore, Philip N Hawkins, Mark B Pepys, Graham W Taylor, Vittorio Bellotti
Dissociation of the native transthyretin (TTR) tetramer is widely accepted as the critical step in TTR amyloid fibrillogenesis. It is modelled by exposure of the protein to non-physiological low pH in vitro and is inhibited by small molecule compounds, such as the drug tafamidis. We have recently identified a new mechano-enzymatic pathway of TTR fibrillogenesis in vitro, catalysed by selective proteolytic cleavage, which produces a high yield of genuine amyloid fibrils. This pathway is efficiently inhibited only by ligands that occupy both binding sites in TTR...
March 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28298483/the-challenges-of-addressing-pediatric-quality-measurement-gaps
#17
Rita Mangione-Smith
No abstract text is available yet for this article.
March 15, 2017: Pediatrics
https://www.readbyqxmd.com/read/28272974/persistence-of-immunity-18-19%C3%A2-years-after-vaccination-against-hepatitis-b-in-2-cohorts-of-vaccinees-primed-as-infants-or-as-adolescents-in-italy
#18
Luisa Romanò, Cristina Galli, Catia Tagliacarne, Maria Elena Tosti, Claudio Velati, Laura Fomiatti, Maria Chironna, Rosa Cristina Coppola, Mario Cuccia, Rossana Mangione, Fosca Marrone, Francesco Saverio Negrone, Antonino Parlato, Carla Maria Zotti, Alfonso Mele, Alessandro Remo Zanetti
This study was aimed at assessing the anti-HBs persistence and immune memory 18-19 y after vaccination against hepatitis B in healthy individuals primed as infants or adolescents. We enrolled 405 teenagers (Group A) vaccinated as infants, and 409 young adults (Group B) vaccinated as adolescents. All vaccinees were tested for anti-HBs and anti-HBc antibodies; those found anti-HBc positive were further tested for HBsAg and HBV DNA. Eight individuals belonging to Group B were positive for anti-HBc alone, and were excluded from analysis...
March 8, 2017: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/28267862/screening-for-gynecologic-conditions-with-pelvic-examination-us-preventive-services-task-force-recommendation-statement
#19
Kirsten Bibbins-Domingo, David C Grossman, Susan J Curry, Michael J Barry, Karina W Davidson, Chyke A Doubeni, John W Epling, Francisco A R García, Alex R Kemper, Alex H Krist, Ann E Kurth, C Seth Landefeld, Carol M Mangione, William R Phillips, Maureen G Phipps, Michael Silverstein, Melissa Simon, Albert L Siu, Chien-Wen Tseng
Importance: Many conditions that can affect women's health are often evaluated through pelvic examination. Although the pelvic examination is a common part of the physical examination, it is unclear whether performing screening pelvic examinations in asymptomatic women has a significant effect on disease morbidity and mortality. Objective: To issue a new US Preventive Services Task Force (USPSTF) recommendation on screening for gynecologic conditions with pelvic examination for conditions other than cervical cancer, gonorrhea, and chlamydia, for which the USPSTF has already made specific recommendations...
March 7, 2017: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/28265649/developing-recommendations-for-evidence-based-clinical-preventive-services-for-diverse-populations-methods-of-the-u-s-preventive-services-task-force
#20
Kirsten Bibbins-Domingo, Evelyn Whitlock, Tracy Wolff, Quyen Ngo-Metzger, William R Phillips, Karina W Davidson, Alex H Krist, Jennifer S Lin, Carol M Mangione, Ann E Kurth, Francisco A R García, Susan J Curry, David C Grossman, C Seth Landefeld, John W Epling, Albert L Siu
The U.S. Preventive Services Task Force (USPSTF) summarizes the principles and considerations that guide development of its recommendations for diverse U.S. populations. It uses these principles through each step in the evidence-based guideline process: developing the research plan, conducting the evidence review, developing the recommendation, and communicating to guideline users. Three recent recommendations provide examples of how the USPSTF has used these principles: the 2015 recommendation on screening for abnormal blood glucose and type 2 diabetes; the 2016 recommendation on screening for breast cancer; and the recommendation on screening for prostate cancer, which is currently in progress...
April 18, 2017: Annals of Internal Medicine
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