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https://www.readbyqxmd.com/read/27923199/the-importance-of-vial-composition-in-hplc-analysis-an-unusual-case-of-phosphorous-pseudorotation
#1
Rebecca Arvary, Ian Mangion
Glass HPLC vials are ubiquitous in analytical laboratories and vendors have developed many varieties to meet the various needs of scientists. As such there may be multiple types of vials being used simultaneously in a single laboratory without much consideration as to which is best suited for analytical method development and validation. This study highlights the possibility of vial composition as a potential factor that impacts solution stability. Here we describe a case where the type of HPLC vial used results in an interesting phosphorous pseudorotation driven by the mild alkalinity of glass...
October 6, 2016: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/27916424/caring-for-children-with-medical-complexity-perspectives-of-primary-care-providers
#2
Carolyn C Foster, Rita Mangione-Smith, Tamara D Simon
OBJECTIVE: To describe typical care experiences and key barriers and facilitators to caring for children with medical complexity (CMC) from the perspective of community primary care providers (PCPs). STUDY DESIGN: PCPs participating in a randomized controlled trial of a care-coordination intervention for CMC were sent a 1-time cross-sectional survey that asked PCPs to (1) describe their experiences with caring for CMC; (2) identify key barriers affecting their ability to care for CMC; and (3) prioritize facilitators enhancing their ability to provide care coordination for CMC...
December 2, 2016: Journal of Pediatrics
https://www.readbyqxmd.com/read/27867791/an-assessment-of-forward-and-inverse-gia-solutions-for-antarctica
#3
Alba Martín-Español, Matt A King, Andrew Zammit-Mangion, Stuart B Andrews, Philip Moore, Jonathan L Bamber
In this work we assess the most recent estimates of glacial isostatic adjustment (GIA) for Antarctica, including those from both forward and inverse methods. The assessment is based on a comparison of the estimated uplift rates with a set of elastic-corrected GPS vertical velocities. These have been observed from an extensive GPS network and computed using data over the period 2009-2014. We find systematic underestimations of the observed uplift rates in both inverse and forward methods over specific regions of Antarctica characterized by low mantle viscosities and thin lithosphere, such as the northern Antarctic Peninsula and the Amundsen Sea Embayment, where its recent ice discharge history is likely to be playing a role in current GIA...
September 2016: Journal of Geophysical Research. Solid Earth
https://www.readbyqxmd.com/read/27811579/a-comprehensive-approach-to-pediatric-pneumonia-relationship-between-standardization-antimicrobial-stewardship-clinical-testing-and-cost
#4
Lori Rutman, Davene R Wright, James OʼCallaghan, Suzanne Spencer, K Casey Lion, Matthew P Kronman, Chuan Zhou, Rita Mangione-Smith
OBJECTIVE: In September 2012, our institution implemented an emergency department (ED) and inpatient pathway for community-acquired pneumonia (CAP) based on national guideline recommendations. The objective of this study was to determine the relationship between standardizing ED and inpatient care for CAP and antimicrobial stewardship, clinical testing, and cost. METHODS: We used descriptive statistics, statistical process control, and interrupted time series analysis to analyze measures 12 months before and after implementation...
November 1, 2016: Journal for Healthcare Quality: Official Publication of the National Association for Healthcare Quality
https://www.readbyqxmd.com/read/27788931/frequency-of-cardiac-death-and-stent-thrombosis-in-patients-with-chronic-obstructive-pulmonary-disease-undergoing-percutaneous-coronary-intervention-from-the-basket-prove-i-and-ii-trials
#5
Tannas Jatene, Tor Biering-Sørensen, Kotaro Nochioka, Fernanda Marinho Mangione, Kim Wadt Hansen, Rikke Sørensen, Jan Skov Jensen, Peter Godsk Jørgensen, Raban Jeger, Christoph Kaiser, Matthias Pfisterer, Søren Galatius
Chronic obstructive pulmonary disease (COPD) is associated with long-term all-cause death after percutaneous coronary intervention with bare-metal stents. Regarding other outcomes, previous studies have shown conflicting results and the impact of drug-eluting stent (DES) in this population is not well known. We analyzed 4,605 patients who underwent percutaneous coronary intervention with bare-metal stents (33.1%) or DES (66.9%) from the Basel Stent Kosten-Effektivitats Trial-Prospective Validation Examination trials I and II...
September 29, 2016: American Journal of Cardiology
https://www.readbyqxmd.com/read/27784102/primary-care-interventions-to-support-breastfeeding-us-preventive-services-task-force-recommendation-statement
#6
Kirsten Bibbins-Domingo, David C Grossman, Susan J Curry, Karina W Davidson, John W Epling, Francisco A R García, Alex R Kemper, Alex H Krist, Ann E Kurth, C Seth Landefeld, Carol M Mangione, William R Phillips, Maureen G Phipps, Michael P Pignone
Importance: There is convincing evidence that breastfeeding provides substantial health benefits for children. However, nearly half of all US mothers who initially breastfeed stop doing so by 6 months, and there are significant disparities in breastfeeding rates among younger mothers and in disadvantaged communities. Objective: To update the 2008 US Preventive Services Task Force (USPSTF) recommendation on primary care interventions to promote breastfeeding. Evidence Review: The USPSTF reviewed the evidence on the effectiveness of interventions to support breastfeeding on breastfeeding initiation, duration, and exclusivity...
October 25, 2016: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/27763471/fostering-a-commitment-to-quality-best-practices-in-safety-net-hospitals
#7
Michael Hochman, Medell Briggs-Malonson, Erin Wilkes, Jonathan Bergman, Lauren Patty Daskivich, Tannaz Moin, Ilanit Brook, Gery W Ryan, Robert H Brook, Carol M Mangione
In 2007, the Martin Luther King, Jr.-Harbor Hospital (MLK-Harbor), which served a large safety-net population in South Los Angeles, closed due to quality challenges. Shortly thereafter, an agreement was made to establish a new hospital, Martin Luther King, Jr. Community Hospital (MLKCH), to serve the unmet needs of the community. To assist the newly appointed MLKCH Board of Directors in building a culture of quality, we conducted a series of interviews with five high-performing hospital systems. In this report, we describe our findings...
2016: Journal of Health Care for the Poor and Underserved
https://www.readbyqxmd.com/read/27763457/implementing-community-engagement-as-a-mission-at-the-david-geffen-school-of-medicine-at-the-university-of-california-los-angeles
#8
Bowen Chung, Arleen F Brown, Gerardo Moreno, Pattie Cuen, Visith Uy, Sitaram Vangala, Douglas S Bell, A Eugene Washington, Keith C Norris, Carol M Mangione
This manuscript describes the development and implementation of community engagement as a mission at UCLA's David Geffen School of Medicine (DGSOM) and UCLA Health System, and summarizes survey results documenting existing community-engaged projects and interest between 2010 to 2013.
2016: Journal of Health Care for the Poor and Underserved
https://www.readbyqxmd.com/read/27740858/non-viral-nucleic-acid-delivery-methods
#9
Igor Slivac, David Guay, Mathias Mangion, Juliette Champeil, Bruno Gaillet
Delivery of nucleic acid-based molecules in human cells is a highly studied approach for the treatment of several disorders including monogenic diseases and cancers. Non-viral vectors for DNA and RNA transfer, although in general less efficient than virus-based systems, are particularly well adapted mostly due to the absence of biosafety concerns. Non-viral methods could be classified in two main groups: physical and vector-assisted delivery systems. Both groups comprise several different methods, none of them universally applicable...
November 9, 2016: Expert Opinion on Biological Therapy
https://www.readbyqxmd.com/read/27740670/strengthening-the-community-college-pathway-to-medical-school-a-study-of-latino-students-in-california
#10
Efrain Talamantes, Karla Gonzalez, Carol M Mangione, Gery Ryan, Alejandro Jimenez, Fabio Gonzalez, Seira Santizo Greenwood, David E Hayes-Bautista, Gerardo Moreno
BACKGROUND AND OBJECTIVES: One third of Latino medical students begin their premedical undergraduate education at a community college (CC) or 2-year college, compared to a 4-year university. This study explored the academic and personal experiences Latino premedical students commonly encounter at the CC. METHODS: In 2013, five focus groups with Latino premedical and medical students (n=45) were conducted in Los Angeles and San Jose, CA. All students were enrolled or attended a CC...
October 2016: Family Medicine
https://www.readbyqxmd.com/read/27727404/predictive-value-of-human-cytomegalovirus-hcmv-t-cell-response-in-the-control-of-hcmv-infection-by-seropositive-solid-organ-transplant-recipients-according-to-different-assays-and-stimuli
#11
Elisa Gabanti, Francesca Bruno, Lucia Scaramuzzi, Filippo Mangione, Paola Zelini, Giuseppe Gerna, Daniele Lilleri
Human cytomegalovirus (HCMV) is still the most common viral infection in solid-organ transplant recipients (SOTR). Our study aimed to identify the predictive values of the T-cell response able to protect from HCMV disease, according to different assays. Viral DNA was determined by real-time PCR. The T-cell immune response to HCMV infection was investigated in SOTR according to the following assays and stimuli: cytokine flow cytometry (CFC) after peripheral blood mononuclear cell (PBMC) stimulation with autologous HCMV-infected dendritic cells (iDC) vs three ELISPOT assays using PBMCs stimulated with: i) HCMV-infected cell lysate (iCL); ii) a pool of 34 epitopic peptides (PP) from different HCMV proteins; iii) a commercial pp65 peptide pool (CPM)...
September 13, 2016: New Microbiologica
https://www.readbyqxmd.com/read/27700080/a-mild-cu-i-catalyzed-oxidative-aromatization-of-indolines-to-indoles
#12
Feng Peng, Mark McLaughlin, Yizhou Liu, Ian Mangion, David M Tschaen, Yingju Xu
A novel method for the oxidation of indolines to indoles using a Cu(I) catalyst and an organic percarbonate as the stoichiometric oxidant is described. The method was successfully applied to the production of 0.5 kg of a key intermediate in the synthesis of Elbasvir, which is a novel therapy for the treatment of hepatitis C virus infection.
October 4, 2016: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/27623462/association-between-transcatheter-aortic-valve-replacement-and-subsequent-infective-endocarditis-and-in-hospital-death
#13
Ander Regueiro, Axel Linke, Azeem Latib, Nikolaj Ihlemann, Marina Urena, Thomas Walther, Oliver Husser, Howard C Herrmann, Luis Nombela-Franco, Asim N Cheema, Hervé Le Breton, Stefan Stortecky, Samir Kapadia, Antonio L Bartorelli, Jan Malte Sinning, Ignacio Amat-Santos, Antonio Munoz-Garcia, Stamatios Lerakis, Enrique Gutiérrez-Ibanes, Mohamed Abdel-Wahab, Didier Tchetche, Luca Testa, Helene Eltchaninoff, Ugolino Livi, Juan Carlos Castillo, Hasan Jilaihawi, John G Webb, Marco Barbanti, Susheel Kodali, Fabio S de Brito, Henrique B Ribeiro, Antonio Miceli, Claudia Fiorina, Guglielmo Mario Actis Dato, Francesco Rosato, Vicenç Serra, Jean-Bernard Masson, Harindra C Wijeysundera, Jose A Mangione, Maria-Cristina Ferreira, Valter C Lima, Luiz A Carvalho, Alexandre Abizaid, Marcos A Marino, Vinicius Esteves, Julio C M Andrea, Francesco Giannini, David Messika-Zeitoun, Dominique Himbert, Won-Keun Kim, Costanza Pellegrini, Vincent Auffret, Fabian Nietlispach, Thomas Pilgrim, Eric Durand, John Lisko, Raj R Makkar, Pedro A Lemos, Martin B Leon, Rishi Puri, Alberto San Roman, Alec Vahanian, Lars Søndergaard, Norman Mangner, Josep Rodés-Cabau
IMPORTANCE: Limited data exist on clinical characteristics and outcomes of patients who had infective endocarditis after undergoing transcatheter aortic valve replacement (TAVR). OBJECTIVE: To determine the associated factors, clinical characteristics, and outcomes of patients who had infective endocarditis after TAVR. DESIGN, SETTING, AND PARTICIPANTS: The Infectious Endocarditis after TAVR International Registry included patients with definite infective endocarditis after TAVR from 47 centers from Europe, North America, and South America between June 2005 and October 2015...
September 13, 2016: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/27599331/screening-for-latent-tuberculosis-infection-in-adults-us-preventive-services-task-force-recommendation-statement
#14
COMMENT
Kirsten Bibbins-Domingo, David C Grossman, Susan J Curry, Linda Bauman, Karina W Davidson, John W Epling, Francisco A R García, Jessica Herzstein, Alex R Kemper, Alex H Krist, Ann E Kurth, C Seth Landefeld, Carol M Mangione, William R Phillips, Maureen G Phipps, Michael P Pignone
IMPORTANCE: Tuberculosis remains an important preventable disease in the United States. An effective strategy for reducing the transmission, morbidity, and mortality of active disease is the identification and treatment of latent tuberculosis infection (LTBI) to prevent progression to active disease. OBJECTIVE: To issue a current US Preventive Services Task Force (USPSTF) recommendation on screening for LTBI. EVIDENCE REVIEW: The USPSTF reviewed the evidence on screening for LTBI in asymptomatic adults seen in primary care, including evidence dating from the inception of searched databases...
September 6, 2016: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/27585509/genetic-screening-of-anderson-fabry-disease-in-probands-referred-from-multispecialty-clinics
#15
Valentina Favalli, Eliana Disabella, Mariadelfina Molinaro, Marilena Tagliani, Anna Scarabotto, Alessandra Serio, Maurizia Grasso, Nupoor Narula, Carmela Giorgianni, Clelia Caspani, Monica Concardi, Manuela Agozzino, Calogero Giordano, Alexandra Smirnova, Takahide Kodama, Lorenzo Giuliani, Elena Antoniazzi, Riccardo G Borroni, Camilla Vassallo, Filippo Mangione, Laura Scelsi, Stefano Ghio, Carlo Pellegrini, Marialuisa Zedde, Laura Fancellu, GianPietro Sechi, Antonello Ganau, Stefania Piga, Annarita Colucci, Daniela Concolino, Maria Teresa Di Mascio, Danilo Toni, Marina Diomedi, Claudio Rapezzi, Elena Biagini, Massimiliano Marini, Maurizia Rasura, Maurizio Melis, Antonia Nucera, Donata Guidetti, Michelangelo Mancuso, Umberto Scoditti, Pamela Cassini, Jagat Narula, Luigi Tavazzi, Eloisa Arbustini
BACKGROUND: Anderson-Fabry disease (AFD) is a rare X-linked lysosomal storage disease, caused by defects of the alpha-galactosidase A (GLA) gene. AFD can affect the heart, brain, kidney, eye, skin, peripheral nerves, and gastrointestinal tract. Cardiology (hypertrophic cardiomyopathy), neurology (cryptogenic stroke), and nephrology (end-stage renal failure) screening studies suggest the prevalence of GLA variants is 0.62%, with diagnosis confirmation in 0.12%. OBJECTIVES: This study sought to expand screening from these settings to include ophthalmology, dermatology, gastroenterology, internal medicine, pediatrics, and medical genetics to increase diagnostic yield and comprehensively evaluate organ involvement in AFD patients...
September 6, 2016: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/27584468/effect-of-rest-time-in-sprint-training-in-young-soccer-players-2433-board-5-june-3-9-30-am-11-30-am
#16
Juan C Mazza, Raúl R Festa, Carlos Groppo, Lisandro Ruffo, Lucas Maggiolo, Pablo Mangione, Patricia Cosolito, Gustavo Grossi
No abstract text is available yet for this article.
May 2016: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/27570866/effect-of-care-guided-by-cardiovascular-magnetic-resonance-myocardial-perfusion-scintigraphy-or-nice-guidelines-on-subsequent-unnecessary-angiography-rates-the-ce-marc-2-randomized-clinical-trial
#17
RANDOMIZED CONTROLLED TRIAL
John P Greenwood, David P Ripley, Colin Berry, Gerry P McCann, Sven Plein, Chiara Bucciarelli-Ducci, Erica Dall'Armellina, Abhiram Prasad, Petra Bijsterveld, James R Foley, Kenneth Mangion, Mark Sculpher, Simon Walker, Colin C Everett, David A Cairns, Linda D Sharples, Julia M Brown
IMPORTANCE: Among patients with suspected coronary heart disease (CHD), rates of invasive angiography are considered too high. OBJECTIVE: To test the hypothesis that among patients with suspected CHD, cardiovascular magnetic resonance (CMR)-guided care is superior to National Institute for Health and Care Excellence (NICE) guidelines-directed care and myocardial perfusion scintigraphy (MPS)-guided care in reducing unnecessary angiography. DESIGN, SETTING, AND PARTICIPANTS: Multicenter, 3-parallel group, randomized clinical trial using a pragmatic comparative effectiveness design...
September 13, 2016: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/27555125/assessing-student-usage-perception-and-the-utility-of-a-web-based-simulation-in-a-third-year-medical-school-clerkship
#18
Eric M Wise, William R McIvor, Michael P Mangione
STUDY OBJECTIVE: The goals of this study were to assess students' usage data of Web-based simulation (WBS), to determine if it can fill gaps in clinical experience-based medical education, and to determine students' perceived value of this kind of simulation during a clinical clerkship. DESIGN: Observational/prospective cohort. SETTING: Medical school affiliated with a large academic hospital. SUBJECTS: A total od 138 medical students...
September 2016: Journal of Clinical Anesthesia
https://www.readbyqxmd.com/read/27543132/hemodynamic-correlates-of-blood-pressure-in-older-adults-the-atherosclerosis-risk-in-communities-aric-study
#19
Hirofumi Tanaka, Gerardo Heiss, Elizabeth L McCabe, Michelle L Meyer, Amil M Shah, Judy R Mangion, Justina Wu, Scott D Solomon, Susan Cheng
The primary aim of the present study was to identify the hemodynamic correlates of both steady and pulsatile blood pressure (BP) in community-dwelling older adults. In 3762 adults aged 70 to 89 years, significant hemodynamic determinants of both brachial and carotid systolic BP included arterial stiffness as measured by aortic pulse wave velocity, stroke volume (via echocardiography), arterial wave reflection, left ventricular ejection time, and upstroke time. The strongest influence was exerted by arterial stiffness...
December 2016: Journal of Clinical Hypertension
https://www.readbyqxmd.com/read/27532917/screening-for-lipid-disorders-in-children-and-adolescents-us-preventive-services-task-force-recommendation-statement
#20
Kirsten Bibbins-Domingo, David C Grossman, Susan J Curry, Karina W Davidson, John W Epling, Francisco A R García, Matthew W Gillman, Alex R Kemper, Alex H Krist, Ann E Kurth, C Seth Landefeld, Michael LeFevre, Carol M Mangione, Douglas K Owens, William R Phillips, Maureen G Phipps, Michael P Pignone, Albert L Siu
IMPORTANCE: Elevations in levels of total, low-density lipoprotein, and non-high-density lipoprotein cholesterol; lower levels of high-density lipoprotein cholesterol; and, to a lesser extent, elevated triglyceride levels are associated with risk of cardiovascular disease in adults. OBJECTIVE: To update the 2007 US Preventive Services Task Force (USPSTF) recommendation on screening for lipid disorders in children, adolescents, and young adults. EVIDENCE REVIEW: The USPSTF reviewed the evidence on screening for lipid disorders in children and adolescents 20 years or younger--1 review focused on screening for heterozygous familial hypercholesterolemia, and 1 review focused on screening for multifactorial dyslipidemia...
August 9, 2016: JAMA: the Journal of the American Medical Association
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