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https://www.readbyqxmd.com/read/29325912/impact-of-the-childhood-vaccine-discussion-format-over-time-on-immunization-status
#1
Douglas J Opel, Chuan Zhou, Jeffrey D Robinson, Nora Henrikson, Katherine Lepere, Rita Mangione-Smith, James A Taylor
OBJECTIVE: Presumptive formats to initiate childhood vaccine discussions (e.g. "Well we have to do some shots.") have been associated with increased vaccine acceptance after one visit compared to participatory formats (e.g. "How do you feel about vaccines?"). We characterize discussion format patterns over time and the impact of their repeated use on vaccine acceptance. METHODS: We conducted a longitudinal prospective cohort study of children of vaccine-hesitant parents enrolled in a Seattle-based integrated health system...
January 8, 2018: Academic Pediatrics
https://www.readbyqxmd.com/read/29318284/screening-for-adolescent-idiopathic-scoliosis-us-preventive-services-task-force-recommendation-statement
#2
David C Grossman, Susan J Curry, Douglas K Owens, Michael J Barry, Karina W Davidson, Chyke A Doubeni, John W Epling, Alex R Kemper, Alex H Krist, Ann E Kurth, C Seth Landefeld, Carol M Mangione, Maureen G Phipps, Michael Silverstein, Melissa A Simon, Chien-Wen Tseng
Importance: Adolescent idiopathic scoliosis, a lateral curvature of the spine of unknown cause with a Cobb angle of at least 10°, occurs in children and adolescents aged 10 to 18 years. Idiopathic scoliosis is the most common form and usually worsens during adolescence before skeletal maturity. Severe spinal curvature may be associated with adverse long-term health outcomes (eg, pulmonary disorders, disability, back pain, psychological effects, cosmetic issues, and reduced quality of life)...
January 9, 2018: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/29311178/using-state-administrative-data-to-identify-social-complexity-risk-factors-for-children
#3
Kimberly C Arthur, Barbara A Lucenko, Irina V Sharkova, Jingping Xing, Rita Mangione-Smith
PURPOSE: Screening for social determinants of health is challenging but critically important for optimizing child health outcomes. We aimed to test the feasibility of using an integrated state agency administrative database to identify social complexity risk factors and examined their relationship to emergency department (ED) use. METHODS: We conducted a retrospective cohort study among children younger than 18 years with Washington State Medicaid insurance coverage (N = 505,367)...
January 2018: Annals of Family Medicine
https://www.readbyqxmd.com/read/29305125/image-based-mri-gradient-estimation
#4
R Acquaviva, S Mangione, G Garbo
In order to reduce geometric distortion phenomena in MR images, every MRI system main magnet undergoes a shimming process. Since this process aims at optimizing magnetic field homogeneity within a so-called uniformity sphere, image quality outside this sphere is neglected. Since the fields vary smoothly in space, MR signal-to-noise ratio is still non-zero just outside the uniformity region, but correction of MR image distortion fails due to lack of magnetic field knowledge outside it. We propose a novel algorithm for measuring all the fields involved in the generation of images...
January 2, 2018: Magnetic Resonance Imaging
https://www.readbyqxmd.com/read/29287928/making-all-medications-gluten-free
#5
Ankita V Shah, Abu T M Serajuddin, Robert A Mangione
Gluten is found in food containing wheat, rye, and barley, and it may be introduced into medicines through the use of starch or any modified form of starch derived from these grains. The ingestion of gluten poses serious health hazards to people with celiac disease and non-celiac gluten sensitivity, and they must avoid the oral ingestion of gluten. In 2011, the Food and Drug Administration solicited information and public comments on 'gluten in drug products'. However, the 'final rule' that the Agency issued in 2013 involved only the voluntary 'gluten-free' labeling of food, and it did not include drug products...
December 26, 2017: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29234814/hormone-therapy-for-the-primary-prevention-of-chronic-conditions-in-postmenopausal-women-us-preventive-services-task-force-recommendation-statement
#6
David C Grossman, Susan J Curry, Douglas K Owens, Michael J Barry, Karina W Davidson, Chyke A Doubeni, John W Epling, Alex R Kemper, Alex H Krist, Ann E Kurth, C Seth Landefeld, Carol M Mangione, Maureen G Phipps, Michael Silverstein, Melissa A Simon, Chien-Wen Tseng
Importance: Menopause occurs at a median age of 51.3 years, and the average US woman who reaches menopause is expected to live another 30 years. The prevalence and incidence of most chronic conditions, such as coronary heart disease, dementia, stroke, fractures, and breast cancer, increase with age; however, the excess risk for these conditions that can be attributed to menopause alone is uncertain. Since the publication of findings from the Women's Health Initiative that hormone therapy use is associated with serious adverse health effects in postmenopausal women, use of menopausal hormone therapy has declined...
December 12, 2017: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/29229566/agreement-between-parent-proxy-and-child-self-report-of-pain-intensity-and-health-related-quality-of-life-after-surgery
#7
Brooke E Lifland, Rita Mangione-Smith, Tonya M Palermo, Jennifer A Rabbitts
OBJECTIVES: Monitoring patient-centered health outcomes after hospital discharge is important for identifying patients experiencing poor recovery after surgery. Utilizing parent reports may improve the feasibility of monitoring recovery when children are not available to provide self-report. We therefore aimed to examine agreement between parent and child reports of child pain and health-related quality of life (HRQOL) in children after hospital discharge from inpatient surgery. METHODS: 295 children aged 8-18 years and their parents reported on child pain intensity using an 11-point Numerical Rating Scale and on HRQOL using the 0-to-100 point Pediatric Quality of Life Inventory Version 4...
December 8, 2017: Academic Pediatrics
https://www.readbyqxmd.com/read/29222216/development-of-forced-normalisation-psychosis-with-ethosuximide
#8
Sean Apap Mangion, Fergus Rugg-Gunn
A 50-year-old man with known multidrug resistant coexistent focal and generalised epilepsy was commenced on ethosuximide, with normalisation of his electroencephalogram and cessation of absence seizures. Within 3 weeks, he developed a rapidly worsening paranoid psychosis with visual and olfactory hallucinations. A month after the cessation of ethosuximide and concurrent treatment with olanzapine, his psychosis resolved and permitted reinitiation of ethosuximide at a lower dose without recurrence of psychotic symptoms...
December 7, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/29198542/kawasaki-disease-substantially-impacts-health-related-quality-of-life
#9
Soultana Kourtidou, April E Slee, Margaret E Bruce, Haaland Wren, Rita M Mangione-Smith, Michael A Portman
OBJECTIVE: To prospectively evaluate the acute impact of Kawasaki disease (KD) on health-related quality of life (HRQoL) and to assess deterioration in the HRQoL experienced by children with KD compared with other childhood diseases. STUDY DESIGN: We merged the Outcomes Assessment Program database obtained prospectively with the existing KD database and queried for KD admissions between 1 month and 13 years of age. HRQoL was evaluated with the parent-proxy Pediatric Quality of Life Inventory (PedsQL) 4...
November 30, 2017: Journal of Pediatrics
https://www.readbyqxmd.com/read/29192004/effectiveness-of-a-comprehensive-case-management-service-for-children-with-medical-complexity
#10
RANDOMIZED CONTROLLED TRIAL
Tamara D Simon, Kathryn B Whitlock, Wren Haaland, Davene R Wright, Chuan Zhou, John Neff, Waylon Howard, Brian Cartin, Rita Mangione-Smith
OBJECTIVES: To assess whether children with medical complexity (CMC) exposed to a hospital-based comprehensive case management service (CCMS) experience improved health care quality, improved functional status, reduced hospital-based utilization, and/or reduced overall health care costs. METHODS: Eligible CMC at Seattle Children's Hospital were enrolled in a cluster randomized controlled trial between December 1, 2010, and September 29, 2014. Participating primary care providers (PCPs) were randomly assigned, and CMC either had access to an outpatient hospital-based CCMS or usual care directed by their PCP...
December 2017: Pediatrics
https://www.readbyqxmd.com/read/29151225/association-between-different-dietary-polyphenol-subclasses-and-the-improvement-in-cardiometabolic-risk-factors-evidence-from-a-randomized-controlled-clinical-trial
#11
Claudia Vetrani, Marilena Vitale, Lutgarda Bozzetto, Giuseppe Della Pepa, Sara Cocozza, Giuseppina Costabile, Anna Mangione, Paola Cipriano, Giovanni Annuzzi, Angela A Rivellese
AIMS: Due to their different chemical structures and metabolism, polyphenol subclasses may have specific impact on cardiometabolic risk factors. Our aim was to evaluate whether the intake of different polyphenol subclasses is associated with clinical outcomes beneficially improved by polyphenols in a nutritional trial performed by our group (postprandial lipid response, glucose homeostasis, early insulin secretion and oxidative stress). METHODS: The present study is a secondary analysis of a nutritional intervention study with a diet naturally rich in polyphenols...
November 18, 2017: Acta Diabetologica
https://www.readbyqxmd.com/read/29127185/advances-in-computational-modelling-for-personalised-medicine-after-myocardial-infarction
#12
REVIEW
Kenneth Mangion, Hao Gao, Dirk Husmeier, Xiaoyu Luo, Colin Berry
Myocardial infarction (MI) is a leading cause of premature morbidity and mortality worldwide. Determining which patients will experience heart failure and sudden cardiac death after an acute MI is notoriously difficult for clinicians. The extent of heart damage after an acute MI is informed by cardiac imaging, typically using echocardiography or sometimes, cardiac magnetic resonance (CMR). These scans provide complex data sets that are only partially exploited by clinicians in daily practice, implying potential for improved risk assessment...
November 10, 2017: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/29100860/development-of-new-quality-measures-for-hospital-based-care-of-suicidal-youth
#13
Layla Parast, Naomi S Bardach, Q Burkhart, Laura P Richardson, J Michael Murphy, Courtney A Gidengil, Maria T Britto, Marc N Elliott, Rita Mangione-Smith
OBJECTIVES: To develop, validate, and test the feasibility of implementation of four new quality measures assessing ED and inpatient care for suicidal youth. METHODS: Four quality measures were developed to assess hospital-based care for suicidal youth. These measures, focused on counseling caregivers about a) restricting access to lethal means of self-harm and b) benefits and risks of anti-depressant medications, were operationalized into 2 caregiver surveys, assessing ED and inpatient quality, respectively...
October 31, 2017: Academic Pediatrics
https://www.readbyqxmd.com/read/29070834/myocardial-changes-in-incident-haemodialysis-patients-over-6-months-an-observational-cardiac-magnetic-resonance-imaging-study
#14
Elaine Rutherford, Kenneth Mangion, Christie McComb, Elizabeth Bell, Samantha Cockburn, Mohammed Talle, Giles Roditi, Paul Welsh, Rosemary Woodward, Aleksandra Radjenovic, Allan D Struthers, Alan G Jardine, Colin Berry, Rajan K Patel, Patrick B Mark
Patients commencing on haemodialysis (HD) have an increased risk of cardiovascular events in the first year after starting HD compared to those patients established on HD longer. Left ventricular (LV) hypertrophy and abnormal myocardial strain predict mortality. There may be changes in the myocardium of incident HD patients over a 6-month period of HD which may explain changes in cardiovascular risk. We used CMR to consider changes in LV mass, myocardial strain and T1 mapping. We examined changes in pre-dialysis highly sensitive troponin T...
October 25, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29051544/estimating-prognosis-in-patients-with-acute-myocardial-infarction-using-personalized-computational-heart-models
#15
Hao Gao, Kenneth Mangion, David Carrick, Dirk Husmeier, Xiaoyu Luo, Colin Berry
Biomechanical computational models have potential prognostic utility in patients after an acute ST-segment-elevation myocardial infarction (STEMI). In a proof-of-concept study, we defined two groups (1) an acute STEMI group (n = 6, 83% male, age 54 ± 12 years) complicated by left ventricular (LV) systolic dysfunction; (2) an age- and sex- matched hyper-control group (n = 6, 83% male, age 46 ± 14 years), no prior history of cardiovascular disease and normal systolic blood pressure (SBP < 130 mmHg)...
October 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29038132/provider-perspectives-of-high-quality-pediatric-hospital-to-home-transitions-for-children-and-youth-with-chronic-disease
#16
Carolyn C Foster, Elizabeth Jacob-Files, Kimberly C Arthur, Stephanie A Hillman, Todd C Edwards, Rita Mangione-Smith
OBJECTIVE: The objective of this study was to describe health care providers' and hospital administrators' perspectives on how to improve pediatric hospital-to-home transitions for children and youth with chronic disease (CYCD). METHODS: Focus groups and key informant interviews of inpatient attending physicians, primary care physicians, pediatric residents, nurses, care coordinators, and social workers were conducted at a tertiary care children's hospital. Key informant interviews were performed with hospital administrators...
November 2017: Hospital Pediatrics
https://www.readbyqxmd.com/read/29016222/misidentification-of-transthyretin-and-immunoglobulin-variants-by-proteomics-due-to-methyl-lysine-formation-in-formalin-fixed-paraffin-embedded-amyloid-tissue
#17
Diana Canetti, Nigel Brian Rendell, Lucia Di Vagno, Janet A Gilbertson, Dorota Rowczenio, Tamar Rezk, Julian D Gillmore, Phillip N Hawkins, Guglielmo Verona, Palma Patrizia Mangione, Sofia Giorgetti, Pierluigi Mauri, Sara Motta, Antonella De Palma, Vittorio Bellotti, Graham W Taylor
Proteomics is becoming the de facto gold standard for identifying amyloid proteins and is now used routinely in a number of centres. The technique is compound class independent and offers the added ability to identify variant and modified proteins. We re-examined proteomics results from a number of formalin-fixed paraffin-embedded amyloid samples, which were positive for transthyretin (TTR) by immunohistochemistry and proteomics, using the UniProt human protein database modified to include TTR variants. The amyloidogenic variant, V122I TTR, was incorrectly identified in 26/27 wild-type and non-V122I variant samples due to its close mass spectral similarity with the methyl lysine-modified WT peptide [126KMe]105-127 (p...
October 10, 2017: Amyloid: the International Journal of Experimental and Clinical Investigation
https://www.readbyqxmd.com/read/28973282/current-shortcomings-of-camera-screening-reply
#18
Lauren P Daskivich, Carol M Mangione
No abstract text is available yet for this article.
October 1, 2017: JAMA Internal Medicine
https://www.readbyqxmd.com/read/28968143/mental-health-wellness-and-biofield-therapies-an-integrative-review
#19
Lucrezia Mangione, Diane Swengros, Joel G Anderson
Biofield therapies such as Healing Touch and Reiki increase relaxation, decrease anxiety and stress, and improve mood. Understanding the efficacy of these therapies in terms of mental health wellness is important for nurses interested in complementary and integrative care. The goal of the present integrative review was to investigate the state of knowledge regarding biofield therapies and the impact on anxiety, mood, and mental health wellness. Electronic databases were searched for articles available in English and published from 2014 to 2016...
November 2017: Issues in Mental Health Nursing
https://www.readbyqxmd.com/read/28966735/continuous-positive-airway-pressure-is-it-a-route-for-infection-in-those-with-obstructive-sleep-apnoea
#20
Liam Mercieca, Richard Pullicino, Kyra Camilleri, Rodianne Abela, Sean Apap Mangion, Julian Cassar, Matthew Zammit, Christine Gatt, Christopher Deguara, Christopher Barbara, Peter Fsadni, Stephen Montefort
INTRODUCTION: Continuous positive airway pressure (CPAP) is the standard treatment for obstructive sleep apnoea (OSA), with limited data about the prevalence of respiratory infections and microbial colonization in these patients. OBJECTIVES: The aim of this study was to determine if CPAP use is associated with respiratory infections and to identify the organisms that colonize or infect these patients. METHOD: A retrospective, case-controlled study in patients diagnosed with OSA was carried out...
January 2017: Sleep Science
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