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JOURNAL ARTICLE
M Caccamo, G Luciano, T Rapisarda, V M Marino, C Pasta, A Natalello, G Mangione, B Valenti, A Campione, G Marino, M Pauselli
The possibility of inclusion of agro-industrial by-products in the diet of small ruminants represents both an economical and an environmental strategy for reducing waste management by industries and the cost of feeding as well as the impact of livestock farming. Large amounts of wastes from the cocoa industry are annually produced with a considerable part represented by cocoa bean shells, considered a suitable ingredient to be included in the diet of ruminants within the limits established by European legislation...
April 18, 2024: Journal of Dairy Science
#2
JOURNAL ARTICLE
Jérémy Lemaire, Rosanna Mangione, Stéphane Caut, Paco Bustamante
Freshwater ecosystems are among the most important ecosystems worldwide, however, over the last centuries, anthropogenic pressures have had catastrophic effects on them. Mercury (Hg) is one of the main environmental contaminants which globally affect ecosystems and particularly freshwater wildlife. While Hg originates from natural sources, anthropogenic activities such as agriculture, biomass combustion, and gold mining increase its concentrations. Gold mining activities are the main drivers of Hg emission in tropical ecosystems and are responsible for up to 38% of global emissions...
April 15, 2024: Heliyon
#3
JOURNAL ARTICLE
David Rombaut, Carine Lefèvre, Tony Rached, Sabrina Bondu, Anne Letessier, Raphael M Mangione, Batoul Farhat, Auriane Lesieur-Pasquier, Daisy Castillo-Guzman, Ismael Boussaid, Chloé Friedrich, Aurore Tourville, Magali De Carvalho, Françoise Levavasseur, Marjorie Leduc, Morgane Le Gall, Sarah Battault, Marie Temple, Alexandre Houy, Didier Bouscary, Lise Willems, Sophie Park, Sophie Raynaud, Thomas Cluzeau, Emmanuelle Clappier, Pierre Fenaux, Lionel Adès, Raphael Margueron, Michel Wassef, Samar Alsafadi, Nicolas Chapuis, Olivier Kosmider, Eric Solary, Angelos Constantinou, Marc-Henri Stern, Nathalie Droin, Benoit Palancade, Benoit Miotto, Frédéric Chédin, Michaela Fontenay
Myelodysplastic syndromes (MDS) with mutated SF3B1 gene present features including a favourable outcome distinct from MDS with mutations in other splicing factor genes SRSF2 or U2AF1. Molecular bases of these divergences are poorly understood. Here we find that SF3B1-mutated MDS show reduced R-loop formation predominating in gene bodies associated with intron retention reduction, not found in U2AF1- or SRSF2-mutated MDS. Compared to erythroblasts from SRSF2- or U2AF1-mutated patients, SF3B1-mutated erythroblasts exhibit augmented DNA synthesis, accelerated replication forks, and single-stranded DNA exposure upon differentiation...
April 8, 2024: Nature Communications
#4
JOURNAL ARTICLE
Allie Eickholtz, Jeremy Mormol, Jesse Kelley, Madi Mangione, Steffen Pounders, Ryan Groseclose, Matthew Lypka, Charles Gibson, Alistair Chapman, Cathryn Chadwick, Laura Krech
This study aims to compare outcomes of rib fracture patients with and without COVID-19 in Michigan. Data from the Michigan Trauma Quality Improvement Program (MTQIP) identified adults hospitalized from January 1, 2020, to October 31, 2022, with at least one rib fracture and a completed COVID-19 test on admission. Patients were propensity score matched 1:1 using 20 variables. The primary outcome was hospital length of stay (LOS). Secondary outcomes were mortality, ventilator days, intensive care unit (ICU) LOS, pneumonia, and ventilator-assisted pneumonia (VAP)...
April 2, 2024: American Surgeon
#5
JOURNAL ARTICLE
Tamra Burns Loeb, Maryam Gholami, Kate Ramm, Kelly Shedd, Samantha Soetenga, Nicholas J Jackson, Un Young Rebecca Chung, O Kenrik Duru, Carol M Mangione, Alison B Hamilton, Tannaz Moin
BACKGROUND: The University of California's Diabetes Prevention Program (UC DPP) Initiative was implemented across all 10 UC campuses in 2018. The COVID-19 pandemic and accompanying mandates required swift changes to program delivery, including pivoting from in-person to virtual delivery (i.e., Zoom). Our goal was to assess multilevel constituent perceptions of the use of a virtual platform to deliver UC DPP due to COVID-19 mandates. METHODS: We conducted qualitative interviews with 68 UC DPP participants, coordinators, and leaders to examine the use of virtual platform delivery on the reach, effectiveness, adoption, implementation, and maintenance (RE-AIM) of UC DPP...
2024: Frontiers in Public Health
#6
JOURNAL ARTICLE
Kevin Garrity, Christie Docherty, Kenneth Mangion, Rosie Woodward, Martin Shaw, Giles Roditi, Benjamin Shelley, Tara Quasim, Philip McCall, Joanne McPeake
BACKGROUND: Sepsis is one of the most common reasons for ICU admission and a leading cause of mortality worldwide. More than one-half of survivors experience significant physical, psychological, or cognitive impairments, often termed post-intensive care syndrome (PICS). Sepsis is recognized increasingly as being associated with a risk of adverse cardiovascular events that is comparable with other major cardiovascular risk factors. It is plausible that sepsis survivors may be at risk of unidentified cardiovascular disease, and this may play a role in functional impairments seen after ICU discharge...
March 2024: CHEST Crit Care
#7
JOURNAL ARTICLE
Robert Sykes, Daniel Doherty, Andrew Morrow, Kenneth Mangion, Ahsan Rushd, Colin Berry
BACKGROUND: Myocardial infarction and non-obstructive coronary arteries (MINOCA) affects 1 in 9 patients with acute coronary syndrome and has no evidence-based therapy. NT-proBNP is an established biomarker associated with prognosis in heart failure and ischemic heart disease, although there is a paucity of data in patients with MINOCA. METHODS: Prospective study of the diagnostic and clinical utility of measuring NT-proBNP in patients with MINOCA without left ventricular dysfunction or heart failure...
September 2023: American heart journal plus: cardiology research and practice
#8
JOURNAL ARTICLE
Martin Wohlwend, Pirkka-Pekka Laurila, Ludger J E Goeminne, Tanes Lima, Ioanna Daskalaki, Xiaoxu Li, Giacomo von Alvensleben, Barbara Crisol, Renata Mangione, Hector Gallart-Ayala, Olivier Burri, Stephen Butler, Jonathan Morris, Nigel Turner, Julijana Ivanisevic, Johan Auwerx
Age-related muscle wasting and dysfunction render the elderly population vulnerable and incapacitated, while underlying mechanisms are poorly understood. Here, we implicate the CERS1 enzyme of the de novo sphingolipid synthesis pathway in the pathogenesis of age-related skeletal muscle impairment. In humans, CERS1 abundance declines with aging in skeletal muscle cells and, correlates with biological pathways involved in muscle function and myogenesis. Furthermore, CERS1 is upregulated during myogenic differentiation...
March 20, 2024: ELife
#9
JOURNAL ARTICLE
Francesca Lavatelli, Antonino Natalello, Loredana Marchese, Diletta Ami, Alessandra Corazza, Sara Raimondi, Maria Chiara Mimmi, Silvia Malinverni, P Patrizia Mangione, Manel Terrones Palmer, Alessio Lampis, Monica Concardi, Guglielmo Verona, Diana Canetti, Eloisa Arbustini, Vittorio Bellotti, Sofia Giorgetti
AL amyloidosis is a life-threatening disease caused by deposition of immunoglobulin light chains. Whilst the mechanisms underlying light chains amyloidogenesis in vivo remain unclear, several studies have highlighted the role that tissue environment and structural amyloidogenicity of individual light chains have in the disease pathogenesis. AL natural deposits contain both full-length light chains and fragments encompassing the variable domain (VL ) as well as different length segments of the constant region (CL ), thus highlighting the relevance that proteolysis may have in the fibrillogenesis pathway...
March 16, 2024: Journal of Biological Chemistry
#10
JOURNAL ARTICLE
Alice S Ryan, Brock A Beamer, Ann L Gruber-Baldini, Rebecca L Craik, Justine Golden, Jack Guralnik, Marc C Hochberg, Kathleen K Mangione, Denise Orwig, Alan M Rathbun, Jay Magaziner
BACKGROUND: Mechanistic factors on the pathway to improving independent ambulatory ability among hip fracture patients by a multicomponent home-based physical therapy intervention that emphasized aerobic, strength, balance, and functional training are unknown. The aim of this study was to determine the effects of two different home-based physical therapy programs on muscle area and attenuation (reflects muscle density) of the lower extremities, bone mineral density, and aerobic capacity...
March 7, 2024: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
#11
JOURNAL ARTICLE
Andrew J Morrow, Robert Sykes, Merna Saleh, Baryab Zahra, Alasdair MacIntosh, Anna Kamdar, Catherine Bagot, Hannah K Bayes, Kevin G Blyth, Heerajnarain Bulluck, David Carrick, Colin Church, David Corcoran, Iain Findlay, Vivienne B Gibson, Lynsey Gillespie, Douglas Grieve, Pauline Hall Barrientos, Antonia Ho, Ninian N Lang, David J Lowe, Vera Lennie, Peter W Macfarlane, Kaitlin J Mayne, Patrick B Mark, Alex McConnachie, Ross McGeoch, Sabrina Nordin, Alexander Payne, Alastair J Rankin, Keith Robertson, Nicola Ryan, Giles Roditi, Naveed Sattar, David Stobo, Sarah Allwood-Spiers, Rhian M Touyz, Gruschen Veldtman, Sarah Weeden, Robin Weir, Stuart Watkins, Paul Welsh, Kenneth Mangion, Colin Berry
BACKGROUND: The associations between deprivation and illness trajectory after hospitalisation for coronavirus disease-19 (COVID-19) are uncertain. METHODS: A prospective, multicentre cohort study was conducted on post-COVID-19 patients, enrolled either in-hospital or shortly post-discharge. Two evaluations were carried out: an initial assessment and a follow-up at 28-60 days post-discharge. The study encompassed research blood tests, patient-reported outcome measures, and multisystem imaging (including chest computed tomography (CT) with pulmonary and coronary angiography, cardiovascular and renal magnetic resonance imaging)...
February 28, 2024: Commun Med (Lond)
#12
JOURNAL ARTICLE
Guglielmo Verona, Sara Raimondi, Diana Canetti, P Patrizia Mangione, Loredana Marchese, Alessandra Corazza, Francesca Lavatelli, Julian D Gillmore, Graham W Taylor, Vittorio Bellotti, Sofia Giorgetti
The mechanism that converts native human transthyretin into amyloid fibrils in vivo is still a debated and controversial issue. Commonly, non-physiological conditions of pH, temperature, or organic solvents are used in in vitro models of fibrillogenesis of globular proteins. Transthyretin amyloid formation can be achieved under physiological conditions through a mechano-enzymatic mechanism involving specific serine proteases such as trypsin or plasmin. Here, we investigate S52P and L111M transthyretin variants, both causing a severe form of systemic amyloidosis mostly targeting the heart at a relatively young age with heterogeneous phenotype among patients...
March 2024: Protein Science
#13
REVIEW
Donatella Mangione, Alessandra Vassiliadis, Giuseppe Gullo, Cetty Gullo, Gaspare Cucinella, Renato Venezia, Simona Zaami
Wernicke Encephalopathy (WE) is a neurological acute syndrome related to vitamin B1 deficiency and is relatively common in patients with chronic alcoholism. In the case of Hyperemesis Gravidarum, thiamine body stores become unable to meet the increased demand, resulting in acute deficiency. WE is associated with typical clinical and radiological findings. Treatment pathways rely on thiamine replacement. The case herein reported is centered around a 33-year-old diabetic patient at 12 weeks of gestation, with WE due to hyperemesis gravidarum...
January 26, 2024: Journal of Clinical Medicine
#14
JOURNAL ARTICLE
Salvatore Mangione, Maria Basile, Stephen G Post
No abstract text is available yet for this article.
February 9, 2024: JAMA
#15
JOURNAL ARTICLE
Masahiro Yasaka, Michiyasu Suzuki, Shigeki Kushimoto, Ayako Kiyonaga, Antoinette Mangione, Yuki Niwa, Naoki Terasaka
INTRODUCTION: Limited data are available regarding the safety and effectiveness of 4-factor prothrombin complex concentrate (4F-PCC) in patients experiencing major hemorrhage or requiring expeditious surgical intervention, both globally and within Japan. METHODS: We executed a prospective, observational post-marketing surveillance study of patients receiving 4F-PCC for the first time between September 19, 2017 and August 15, 2018 in Japan. Patients were subjected to a comprehensive follow-up for a duration of 4 weeks...
February 6, 2024: Cardiology and Therapy
#16
JOURNAL ARTICLE
Nicolas Aurouer, Patrick Guerin, Arnaud Cogniet, Nicolas Gangnet, Morad Pedram, Pierre-Thierry Piechaud, Paolo Mangione
BACKGROUND: Robotic spinal surgery may result in better pedicle screw placement accuracy, and reduction in radiation exposure and length of stay, compared to freehand surgery. The purpose of this randomized controlled trial (RCT) is to compare screw placement accuracy of robot-assisted surgery with integrated 3D computer-assisted navigation versus freehand surgery with 2D fluoroscopy for arthrodesis of the thoraco-lumbar spine. METHODS: This is a single-centre evaluator-blinded RCT with a 1:1 allocation ratio...
February 3, 2024: Trials
#17
JOURNAL ARTICLE
Karl Mangion, Kevin Vella, Alex Gatt, Amy Marie Vella, Marica Borg, Denise Borg-Aquilina, Jonathan Douxfils, Liberato Camilleri, Nicoletta Riva
BACKGROUND: Several generic formulations of rivaroxaban were recently marketed to be used interchangeably with their branded equivalent. However, there have been no previously published studies that directly compared the in vitro anticoagulant effect of branded vs. generic rivaroxaban. The aim of this in vitro study was to compare the effects of three raw rivaroxaban materials, obtained from the branded (Xarelto®) and two generic (Rivarolto® and Rivaroxaban Sandoz®) rivaroxaban formulations on an array of coagulation assays...
January 24, 2024: Thrombosis Research
#18
JOURNAL ARTICLE
Michael J Barry, Wanda K Nicholson, Michael Silverstein, David Chelmow, Tumaini Rucker Coker, Esa M Davis, Katrina E Donahue, Carlos Roberto Jaén, Li Li, Carol M Mangione, Gbenga Ogedegbe, Goutham Rao, John M Ruiz, James Stevermer, Joel Tsevat, Sandra Millon Underwood, John B Wong
IMPORTANCE: Speech and language delays and disorders can pose significant problems for children and their families. Evidence suggests that school-aged children with speech or language delays may be at increased risk of learning and literacy disabilities, including difficulties with reading and writing. OBJECTIVE: The US Preventive Services Task Force (USPSTF) commissioned a systematic review to evaluate benefits and harms of screening for speech and language delay and disorders in children 5 years or younger...
January 23, 2024: JAMA
#19
JOURNAL ARTICLE
Philippe François, Aurélie Benoit, Lotfi Slimani, Ambre Dufresne, Hélène Gouze, Jean-Pierre Attal, Francesca Mangione, Elisabeth Dursun
OBJECTIVE: The aim of this study was to evaluate the remineralizing properties of ion-releasing restorative materials on pH cycling-induced carious dentin. METHODS: Fifty sound molars were freshly extracted. The occlusal surfaces were abraded using water-cooled sandpaper (800 grit). The residual crowns were embedded in self-cured acrylic resin with the flat dentin surface exposed. A mesio-distal trench was created using a calibrated 0.5 mm deep occlusal reduction burr, and artificial dentin caries were generated by pH cycling...
January 10, 2024: Dental Materials
#20
EDITORIAL
Salvatore Mangione
No abstract text is available yet for this article.
January 8, 2024: Journal of General Internal Medicine
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