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https://www.readbyqxmd.com/read/28302347/fungemia-due-to-saprochaete-capitata-in-a-non-neutropenic-patient-hospitalized-in-an-intensive-care-unit-after-cardiac-surgery
#1
C Cavanna, F Lallitto, F Mangione, F Tamarozzi, P Marone, P Ceriana
The majority of invasive fungal infections observed in non-neutropenic patients hospitalized in an intensive care unit are caused by Candida spp and current guidelines recommend echinocandins as the first-line treatment. Fungemias caused by filamentous or arthrosporic fungi such as Saprochaete capitata (previously named Geotrichum capitatum) are extremely rare. In fact, invasive infections due to S. capitata have been reported almost exclusively in neutropenic oncohematological patients. In this report, we describe a case of fungemia caused by S...
March 14, 2017: Journal de Mycologie Médicale
https://www.readbyqxmd.com/read/28298647/inhibition-of-the-mechano-enzymatic-amyloidogenesis-of-transthyretin-role-of-ligand-affinity-binding-cooperativity-and-occupancy-of-the-inner-channel
#2
Guglielmo Verona, P Patrizia Mangione, Sara Raimondi, Sofia Giorgetti, Giulia Faravelli, Riccardo Porcari, Alessandra Corazza, Julian D Gillmore, Philip N Hawkins, Mark B Pepys, Graham W Taylor, Vittorio Bellotti
Dissociation of the native transthyretin (TTR) tetramer is widely accepted as the critical step in TTR amyloid fibrillogenesis. It is modelled by exposure of the protein to non-physiological low pH in vitro and is inhibited by small molecule compounds, such as the drug tafamidis. We have recently identified a new mechano-enzymatic pathway of TTR fibrillogenesis in vitro, catalysed by selective proteolytic cleavage, which produces a high yield of genuine amyloid fibrils. This pathway is efficiently inhibited only by ligands that occupy both binding sites in TTR...
March 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28298483/the-challenges-of-addressing-pediatric-quality-measurement-gaps
#3
Rita Mangione-Smith
No abstract text is available yet for this article.
March 15, 2017: Pediatrics
https://www.readbyqxmd.com/read/28272974/persistence-of-immunity-18-19%C3%A2-years-after-vaccination-against-hepatitis-b-in-2-cohorts-of-vaccinees-primed-as-infants-or-as-adolescents-in-italy
#4
Luisa Romanò, Cristina Galli, Catia Tagliacarne, Maria Elena Tosti, Claudio Velati, Laura Fomiatti, Maria Chironna, Rosa Cristina Coppola, Mario Cuccia, Rossana Mangione, Fosca Marrone, Francesco Saverio Negrone, Antonino Parlato, Carla Maria Zotti, Alfonso Mele, Alessandro Remo Zanetti
This study was aimed at assessing the anti-HBs persistence and immune memory 18-19 y after vaccination against hepatitis B in healthy individuals primed as infants or adolescents. We enrolled 405 teenagers (Group A) vaccinated as infants, and 409 young adults (Group B) vaccinated as adolescents. All vaccinees were tested for anti-HBs and anti-HBc antibodies; those found anti-HBc positive were further tested for HBsAg and HBV DNA. Eight individuals belonging to Group B were positive for anti-HBc alone, and were excluded from analysis...
March 8, 2017: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/28267862/screening-for-gynecologic-conditions-with-pelvic-examination-us-preventive-services-task-force-recommendation-statement
#5
Kirsten Bibbins-Domingo, David C Grossman, Susan J Curry, Michael J Barry, Karina W Davidson, Chyke A Doubeni, John W Epling, Francisco A R García, Alex R Kemper, Alex H Krist, Ann E Kurth, C Seth Landefeld, Carol M Mangione, William R Phillips, Maureen G Phipps, Michael Silverstein, Melissa Simon, Albert L Siu, Chien-Wen Tseng
Importance: Many conditions that can affect women's health are often evaluated through pelvic examination. Although the pelvic examination is a common part of the physical examination, it is unclear whether performing screening pelvic examinations in asymptomatic women has a significant effect on disease morbidity and mortality. Objective: To issue a new US Preventive Services Task Force (USPSTF) recommendation on screening for gynecologic conditions with pelvic examination for conditions other than cervical cancer, gonorrhea, and chlamydia, for which the USPSTF has already made specific recommendations...
March 7, 2017: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/28265649/developing-recommendations-for-evidence-based-clinical-preventive-services-for-diverse-populations-methods-of-the-u-s-preventive-services-task-force
#6
Kirsten Bibbins-Domingo, Evelyn Whitlock, Tracy Wolff, Quyen Ngo-Metzger, William R Phillips, Karina W Davidson, Alex H Krist, Jennifer S Lin, Carol M Mangione, Ann E Kurth, Francisco A R García, Susan J Curry, David C Grossman, C Seth Landefeld, John W Epling, Albert L Siu
The U.S. Preventive Services Task Force (USPSTF) summarizes the principles and considerations that guide development of its recommendations for diverse U.S. populations. It uses these principles through each step in the evidence-based guideline process: developing the research plan, conducting the evidence review, developing the recommendation, and communicating to guideline users. Three recent recommendations provide examples of how the USPSTF has used these principles: the 2015 recommendation on screening for abnormal blood glucose and type 2 diabetes; the 2016 recommendation on screening for breast cancer; and the recommendation on screening for prostate cancer, which is currently in progress...
March 7, 2017: Annals of Internal Medicine
https://www.readbyqxmd.com/read/28265615/citrate-stabilized-gold-nanoparticles-hinder-fibrillogenesis-of-a-pathological-variant-of-%C3%AE-2-microglobulin
#7
Cristina Cantarutti, Sara Raimondi, Giorgia Brancolini, Alessandra Corazza, Sofia Giorgetti, Maurizio Ballico, Stefano Zanini, Giovanni Palmisano, Paolo Bertoncin, Loredana Marchese, P Patrizia Mangione, Vittorio Bellotti, Stefano Corni, Federico Fogolari, Gennaro Esposito
Nanoparticles have repeatedly been shown to enhance fibril formation when assayed with amyloidogenic proteins. Recently, however, evidence casting some doubt about the generality of this conclusion started to emerge. Therefore, to investigate further the influence of nanoparticles on the fibrillation process, we used a naturally occurring variant of the paradigmatic amyloidogenic protein β2-microglobulin (β2m), namely D76N β2m where asparagine replaces aspartate at position 76. This variant is responsible for aggressive systemic amyloidosis...
March 7, 2017: Nanoscale
https://www.readbyqxmd.com/read/28255102/randomized-angiographic-and-intravascular-ultrasound-comparison-of-dual-antiplatelet-therapy-vs-triple-antiplatelet-therapy-to-reduce-neointimal-tissue-proliferation-in-diabetic-patients
#8
Maria Fernanda Zuliani Mauro, J Armando Mangione, J Ribamar Costa, Ricardo Costa, Luiz Alberto Piva E Mattos, Rodolfo Staico, Fausto Feres, Dimytri Siqueira, Amanda Sousa, Alexandre Abizaid
BACKGROUND: Previous studies have suggested a benefit of cilostazol in addition to standard dual-antiplatelet therapy (DAPT), reducing in-stent late luminal loss and restenosis after percutaneous coronary intervention (PCI) with bare-metal and drug-eluting stent (DES) implantation. However, there is a paucity of intravascular ultrasound (IVUS) assessment of neointimal tissue hyperplasia (NIH) after triple-antiplatelet therapy (TAPT), especially in diabetic patients treated with DES. METHODS: This prospective, placebo-controlled trial was conducted in diabetic patients randomized (1:1) to receive either standard DAPT (aspirin and clopidogrel) vs TAPT with cilostazol for a minimum of 12 months after PCI with Endeavor zotarolimus-eluting stent (E-ZES)...
March 2017: Journal of Invasive Cardiology
https://www.readbyqxmd.com/read/28246175/symptoms-and-quality-of-life-in-patients-with-suspected-angina-undergoing-ct-coronary-angiography-a-randomised-controlled-trial
#9
Michelle C Williams, Amanda Hunter, Anoop Shah, Valentina Assi, Stephanie Lewis, Kenneth Mangion, Colin Berry, Nicholas A Boon, Elizabeth Clark, Marcus Flather, John Forbes, Scott McLean, Giles Roditi, Edwin Jr van Beek, Adam D Timmis, David E Newby
BACKGROUND: In patients with suspected angina pectoris, CT coronary angiography (CTCA) clarifies the diagnosis, directs appropriate investigations and therapies, and reduces clinical events. The effect on patient symptoms is currently unknown. METHODS: In a prospective open-label parallel group multicentre randomised controlled trial, 4146 patients with suspected angina due to coronary heart disease were randomised 1:1 to receive standard care or standard care plus CTCA...
February 28, 2017: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/28244947/intermediate-acting-nondepolarizing-neuromuscular-blocking-agents-and-risk-of-postoperative-30-day-morbidity-and-mortality-and-long-term-survival
#10
Michael R Bronsert, William G Henderson, Terri G Monk, Joshua S Richman, Jennifer D Nguyen, John T Sum-Ping, Michael P Mangione, Binh Higley, Karl E Hammermeister
BACKGROUND: Nondepolarizing neuromuscular blocking drugs (NNMBDs) are commonly used as an adjunct to general anesthesia. Residual blockade is common, but its potential adverse effects are incompletely known. This study was designed to assess the association between NNMBD use with or without neostigmine reversal and postoperative morbidity and mortality. METHODS: This is a retrospective observational study of 11,355 adult patients undergoing general anesthesia for noncardiac surgery at 5 Veterans Health Administration (VA) hospitals...
February 24, 2017: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/28239185/the-significance-of-spatial-memory-for-water-finding-in-a-tadpole-transporting-frog
#11
Andrius Pašukonis, Katharina Trenkwalder, Max Ringler, Eva Ringler, Rosanna Mangione, Jolanda Steininger, Ian Warrington, Walter Hödl
The ability to associate environmental cues with valuable resources strongly increases the chances of finding them again, and thus memory often guides animal movement. For example, many temperate region amphibians show strong breeding site fidelity and will return to the same areas even after the ponds have been destroyed. In contrast, many tropical amphibians depend on exploitation of small, scattered and fluctuating resources such as ephemeral pools for reproduction. It remains unknown whether tropical amphibians rely on spatial memory for effective exploitation of their reproductive resources...
June 2016: Animal Behaviour
https://www.readbyqxmd.com/read/28238284/native-t1-mapping-inter-study-inter-observer-and-inter-center-reproducibility-in-hemodialysis-patients
#12
Matthew P M Graham-Brown, Elaine Rutherford, E Levelt, Daniel S March, Darren R Churchward, David J Stensel, Christie McComb, Kenneth Mangion, Samantha Cockburn, Colin Berry, James C Moon, Patrick B Mark, James O Burton, Gerry P McCann
BACKGROUND: Native T1 mapping is a cardiovascular magnetic resonance (CMR) technique that associates with markers of fibrosis and strain in hemodialysis patients. The reproducibility of T1 mapping in hemodialysis patients, prone to changes in fluid status, is unknown. Accurate quantification of myocardial fibrosis in this population has prognostic potential. METHODS: Using 3 Tesla CMR, we report the results of 1) the inter-study, inter-observer and intra-observer reproducibility of native T1 mapping in 10 hemodialysis patients; 2) inter-study reproducibility of left ventricular (LV) structure and function in 10 hemodialysis patients; 3) the agreement of native T1 map and native T1 phantom analyses between two centres in 20 hemodialysis patients; 4) the effect of changes in markers of fluid status on native T1 values in 10 hemodialysis patients...
February 27, 2017: Journal of Cardiovascular Magnetic Resonance
https://www.readbyqxmd.com/read/28223319/development-and-testing-of-the-pediatric-respiratory-illness-measurement-system-primes-quality-indicators
#13
Rita Mangione-Smith, Carol P Roth, Maria T Britto, Alex Y Chen, Julie McGalliard, Thomas F Boat, John L Adams, Elizabeth A McGlynn
OBJECTIVES: To develop and test quality indicators for assessing care in pediatric hospital settings for common respiratory illnesses. PATIENTS: A sample of 2796 children discharged from the emergency department or inpatient setting at 1 of the 3 participating hospitals with a primary diagnosis of asthma, bronchiolitis, croup, or community-acquired pneumonia (CAP) between January 1, 2010, and December 31, 2011. SETTING: Three tertiary care children's hospitals in the United States...
February 21, 2017: Hospital Pediatrics
https://www.readbyqxmd.com/read/28207646/translational-interpretations-of-combined-bupivacaine-clonidine-buprenorphine-dexamethasone
#14
Brian A Williams, James W Ibinson, Catalin S Ezaru, Hulimangala Rakesh, Michael P Mangione
No abstract text is available yet for this article.
March 2017: Regional Anesthesia and Pain Medicine
https://www.readbyqxmd.com/read/28183854/linguistic-isolation-and-access-to-the-active-kidney-transplant-waiting-list-in-the-united-states
#15
Efrain Talamantes, Keith C Norris, Carol M Mangione, Gerardo Moreno, Amy D Waterman, John D Peipert, Suphamai Bunnapradist, Edmund Huang
BACKGROUND AND OBJECTIVES: Waitlist inactivity is a barrier to transplantation, because inactive candidates cannot receive deceased donor organ offers. We hypothesized that temporarily inactive kidney transplant candidates living in linguistically isolated communities would be less likely to achieve active waitlist status. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: We merged Organ Procurement and Transplantation Network/United Network for Organ Sharing data with five-digit zip code socioeconomic data from the 2000 US Census...
March 7, 2017: Clinical Journal of the American Society of Nephrology: CJASN
https://www.readbyqxmd.com/read/28183732/association-of-bronchiolitis-clinical-pathway-adherence-with-length-of-stay-and-costs
#16
Mersine A Bryan, Arti D Desai, Lauren Wilson, Davene R Wright, Rita Mangione-Smith
OBJECTIVES: To examine the associations between the level of adherence to bronchiolitis clinical pathway recommendations, health care use, and costs. METHODS: We conducted a retrospective cohort study of 267 patients ≤24 months old diagnosed with bronchiolitis from 12/2009 to 7/2012. Clinical pathway adherence was assessed by using a standardized scoring system (0-100) for 18 quality measures obtained by medical record review. Level of adherence was categorized into low, middle, and high tertiles...
March 2017: Pediatrics
https://www.readbyqxmd.com/read/28160263/effect-of-prolonged-fasting-and-low-molecular-weight-heparin-or-warfarin-therapies-on-2-deoxy-2-18f-fluoro-d-glucose-pet-cardiac-uptake
#17
Assuero Giorgetti, Gavino Marras, Dario Genovesi, Elena Filidei, Antonio Bottoni, Maurizio Mangione, Michele Emdin, Paolo Marzullo
BACKGROUND: Whether anticoagulants other than unfractionated heparin are able to suppress cardiac PET uptake of 2-deoxy-2-[18F]-fluoro-D-glucose (18F-FDG) is unknown. METHODS: One-hundred-seventy-four patients without history and clinical evidence of cardiac dysfunction and/or coronary heart disease underwent a 18F-FDG PET/CT study. All patients were studied with a >12-hours fasting and divided into 2 groups: group-1 without anticoagulant therapy (n:75); group-2 patients on low molecular weight heparin (n:60) or warfarin therapy (n:39)...
February 3, 2017: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/28118461/screening-for-obstructive-sleep-apnea-in-adults-us-preventive-services-task-force-recommendation-statement
#18
Kirsten Bibbins-Domingo, David C Grossman, Susan J Curry, Karina W Davidson, John W Epling, Francisco A R García, Jessica Herzstein, Alex R Kemper, Alex H Krist, Ann E Kurth, C Seth Landefeld, Carol M Mangione, William R Phillips, Maureen G Phipps, Michael P Pignone, Michael Silverstein, Chien-Wen Tseng
Importance: Based on data from the 1990s, estimated prevalence of obstructive sleep apnea (OSA) in the United States is 10% for mild OSA and 3.8% to 6.5% for moderate to severe OSA; current prevalence may be higher, given the increasing prevalence of obesity. Severe OSA is associated with increased all-cause mortality, cardiovascular disease and cerebrovascular events, diabetes, cognitive impairment, decreased quality of life, and motor vehicle crashes. Objective: To issue a new US Preventive Services Task Force (USPSTF) recommendation on screening for OSA in asymptomatic adults...
January 24, 2017: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/28109043/angiographic-assessment-of-aortic-regurgitation-by-video-densitometry-in-the-setting-of-tavi-echocardiographic-and-clinical-correlates
#19
Mohammad Abdelghani, Hiroki Tateishi, Yosuke Miyazaki, Rafael Cavalcante, Osama I I Soliman, Jan G Tijssen, Robbert J de Winter, Jan Baan, Yoshinobu Onuma, Carlos M Campos, Rogério S Leite, José A Mangione, Alexandre Abizaid, Pedro A Lemos, Fabio S de Brito, Patrick W Serruys
OBJECTIVES: We sought to investigate a new angiographic method for aortic regurgitation (AR) severity assessment in the setting of transcatheter aortic valve implantation (TAVI). BACKGROUND: AR after TAVI is common but challenging to quantitate, especially in the cath-lab. METHODS: In 228 patients, AR was quantitated before and after TAVI by echocardiography and by video-densitometric analysis of aortograms. Contrast time-density curves for the aortic root (the reference region) and the left ventricular outflow tract, LVOT were generated...
January 21, 2017: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/28098264/assessment-of-coulometric-array-electrochemical-detection-coupled-with-hplc-uv-for-the-absolute-quantitation-of-pharmaceuticals
#20
Michael B Hicks, Leah Salituro, Ian Mangion, Wes Schafer, Rong Xiang, Xiaoyi Gong, Christopher J Welch
The use of a coulometric array detector in tandem with HPLC-UV was evaluated for the absolute quantitation of pharmaceutical compounds without standards, an important capability gap in contemporary pharmaceutical research and development. The high-efficiency LC flow-through electrochemical detector system allows for the rapid evaluation of up to 16 different potentials, aiding in the identification and quantitation of electrochemically reactive species. By quantifying the number of electrons added or removed from an analyte during its passage through the detector, the number of moles of the analyte can be established...
January 18, 2017: Analyst
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