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Igor Slivac, David Guay, Mathias Mangion, Juliette Champeil, Bruno Gaillet
Delivery of nucleic acid-based molecules in human cells is a highly studied approach for the treatment of several disorders including monogenic diseases and cancers. Non-viral vectors for DNA and RNA transfer, although in general less efficient than virus-based systems, are particularly well adapted mostly due to the absence of biosafety concerns. Non-viral methods could be classified in two main groups: physical and vector-assisted delivery systems. Both groups comprise several different methods, none of them universally applicable...
October 14, 2016: Expert Opinion on Biological Therapy
Efrain Talamantes, Karla Gonzalez, Carol M Mangione, Gery Ryan, Alejandro Jimenez, Fabio Gonzalez, Seira Santizo Greenwood, David E Hayes-Bautista, Gerardo Moreno
BACKGROUND AND OBJECTIVES: One third of Latino medical students begin their premedical undergraduate education at a community college (CC) or 2-year college, compared to a 4-year university. This study explored the academic and personal experiences Latino premedical students commonly encounter at the CC. METHODS: In 2013, five focus groups with Latino premedical and medical students (n=45) were conducted in Los Angeles and San Jose, CA. All students were enrolled or attended a CC...
October 2016: Family Medicine
Elisa Gabanti, Francesca Bruno, Lucia Scaramuzzi, Filippo Mangione, Paola Zelini, Giuseppe Gerna, Daniele Lilleri
Human cytomegalovirus (HCMV) is still the most common viral infection in solid-organ transplant recipients (SOTR). Our study aimed to identify the predictive values of the T-cell response able to protect from HCMV disease, according to different assays. Viral DNA was determined by real-time PCR. The T-cell immune response to HCMV infection was investigated in SOTR according to the following assays and stimuli: cytokine flow cytometry (CFC) after peripheral blood mononuclear cell (PBMC) stimulation with autologous HCMV-infected dendritic cells (iDC) vs three ELISPOT assays using PBMCs stimulated with: i) HCMV-infected cell lysate (iCL); ii) a pool of 34 epitopic peptides (PP) from different HCMV proteins; iii) a commercial pp65 peptide pool (CPM)...
September 13, 2016: New Microbiologica
Feng Peng, Mark McLaughlin, Yizhou Liu, Ian Mangion, David M Tschaen, Yingju Xu
A novel method for the oxidation of indolines to indoles using a Cu(I) catalyst and an organic percarbonate as the stoichiometric oxidant is described. The method was successfully applied to the production of 0.5 kg of a key intermediate in the synthesis of Elbasvir, which is a novel therapy for the treatment of hepatitis C virus infection.
October 4, 2016: Journal of Organic Chemistry
Ander Regueiro, Axel Linke, Azeem Latib, Nikolaj Ihlemann, Marina Urena, Thomas Walther, Oliver Husser, Howard C Herrmann, Luis Nombela-Franco, Asim N Cheema, Hervé Le Breton, Stefan Stortecky, Samir Kapadia, Antonio L Bartorelli, Jan Malte Sinning, Ignacio Amat-Santos, Antonio Munoz-Garcia, Stamatios Lerakis, Enrique Gutiérrez-Ibanes, Mohamed Abdel-Wahab, Didier Tchetche, Luca Testa, Helene Eltchaninoff, Ugolino Livi, Juan Carlos Castillo, Hasan Jilaihawi, John G Webb, Marco Barbanti, Susheel Kodali, Fabio S de Brito, Henrique B Ribeiro, Antonio Miceli, Claudia Fiorina, Guglielmo Mario Actis Dato, Francesco Rosato, Vicenç Serra, Jean-Bernard Masson, Harindra C Wijeysundera, Jose A Mangione, Maria-Cristina Ferreira, Valter C Lima, Luiz A Carvalho, Alexandre Abizaid, Marcos A Marino, Vinicius Esteves, Julio C M Andrea, Francesco Giannini, David Messika-Zeitoun, Dominique Himbert, Won-Keun Kim, Costanza Pellegrini, Vincent Auffret, Fabian Nietlispach, Thomas Pilgrim, Eric Durand, John Lisko, Raj R Makkar, Pedro A Lemos, Martin B Leon, Rishi Puri, Alberto San Roman, Alec Vahanian, Lars Søndergaard, Norman Mangner, Josep Rodés-Cabau
IMPORTANCE: Limited data exist on clinical characteristics and outcomes of patients who had infective endocarditis after undergoing transcatheter aortic valve replacement (TAVR). OBJECTIVE: To determine the associated factors, clinical characteristics, and outcomes of patients who had infective endocarditis after TAVR. DESIGN, SETTING, AND PARTICIPANTS: The Infectious Endocarditis after TAVR International Registry included patients with definite infective endocarditis after TAVR from 47 centers from Europe, North America, and South America between June 2005 and October 2015...
September 13, 2016: JAMA: the Journal of the American Medical Association
Kirsten Bibbins-Domingo, David C Grossman, Susan J Curry, Linda Bauman, Karina W Davidson, John W Epling, Francisco A R García, Jessica Herzstein, Alex R Kemper, Alex H Krist, Ann E Kurth, C Seth Landefeld, Carol M Mangione, William R Phillips, Maureen G Phipps, Michael P Pignone
IMPORTANCE: Tuberculosis remains an important preventable disease in the United States. An effective strategy for reducing the transmission, morbidity, and mortality of active disease is the identification and treatment of latent tuberculosis infection (LTBI) to prevent progression to active disease. OBJECTIVE: To issue a current US Preventive Services Task Force (USPSTF) recommendation on screening for LTBI. EVIDENCE REVIEW: The USPSTF reviewed the evidence on screening for LTBI in asymptomatic adults seen in primary care, including evidence dating from the inception of searched databases...
September 6, 2016: JAMA: the Journal of the American Medical Association
Valentina Favalli, Eliana Disabella, Mariadelfina Molinaro, Marilena Tagliani, Anna Scarabotto, Alessandra Serio, Maurizia Grasso, Nupoor Narula, Carmela Giorgianni, Clelia Caspani, Monica Concardi, Manuela Agozzino, Calogero Giordano, Alexandra Smirnova, Takahide Kodama, Lorenzo Giuliani, Elena Antoniazzi, Riccardo G Borroni, Camilla Vassallo, Filippo Mangione, Laura Scelsi, Stefano Ghio, Carlo Pellegrini, Marialuisa Zedde, Laura Fancellu, GianPietro Sechi, Antonello Ganau, Stefania Piga, Annarita Colucci, Daniela Concolino, Maria Teresa Di Mascio, Danilo Toni, Marina Diomedi, Claudio Rapezzi, Elena Biagini, Massimiliano Marini, Maurizia Rasura, Maurizio Melis, Antonia Nucera, Donata Guidetti, Michelangelo Mancuso, Umberto Scoditti, Pamela Cassini, Jagat Narula, Luigi Tavazzi, Eloisa Arbustini
BACKGROUND: Anderson-Fabry disease (AFD) is a rare X-linked lysosomal storage disease, caused by defects of the alpha-galactosidase A (GLA) gene. AFD can affect the heart, brain, kidney, eye, skin, peripheral nerves, and gastrointestinal tract. Cardiology (hypertrophic cardiomyopathy), neurology (cryptogenic stroke), and nephrology (end-stage renal failure) screening studies suggest the prevalence of GLA variants is 0.62%, with diagnosis confirmation in 0.12%. OBJECTIVES: This study sought to expand screening from these settings to include ophthalmology, dermatology, gastroenterology, internal medicine, pediatrics, and medical genetics to increase diagnostic yield and comprehensively evaluate organ involvement in AFD patients...
September 6, 2016: Journal of the American College of Cardiology
Juan C Mazza, Raúl R Festa, Carlos Groppo, Lisandro Ruffo, Lucas Maggiolo, Pablo Mangione, Patricia Cosolito, Gustavo Grossi
No abstract text is available yet for this article.
May 2016: Medicine and Science in Sports and Exercise
John P Greenwood, David P Ripley, Colin Berry, Gerry P McCann, Sven Plein, Chiara Bucciarelli-Ducci, Erica Dall'Armellina, Abhiram Prasad, Petra Bijsterveld, James R Foley, Kenneth Mangion, Mark Sculpher, Simon Walker, Colin C Everett, David A Cairns, Linda D Sharples, Julia M Brown
IMPORTANCE: Among patients with suspected coronary heart disease (CHD), rates of invasive angiography are considered too high. OBJECTIVE: To test the hypothesis that among patients with suspected CHD, cardiovascular magnetic resonance (CMR)-guided care is superior to National Institute for Health and Care Excellence (NICE) guidelines-directed care and myocardial perfusion scintigraphy (MPS)-guided care in reducing unnecessary angiography. DESIGN, SETTING, AND PARTICIPANTS: Multicenter, 3-parallel group, randomized clinical trial using a pragmatic comparative effectiveness design...
September 13, 2016: JAMA: the Journal of the American Medical Association
Eric M Wise, William R McIvor, Michael P Mangione
STUDY OBJECTIVE: The goals of this study were to assess students' usage data of Web-based simulation (WBS), to determine if it can fill gaps in clinical experience-based medical education, and to determine students' perceived value of this kind of simulation during a clinical clerkship. DESIGN: Observational/prospective cohort. SETTING: Medical school affiliated with a large academic hospital. SUBJECTS: A total od 138 medical students...
September 2016: Journal of Clinical Anesthesia
Hirofumi Tanaka, Gerardo Heiss, Elizabeth L McCabe, Michelle L Meyer, Amil M Shah, Judy R Mangion, Justina Wu, Scott D Solomon, Susan Cheng
The primary aim of the present study was to identify the hemodynamic correlates of both steady and pulsatile blood pressure (BP) in community-dwelling older adults. In 3762 adults aged 70 to 89 years, significant hemodynamic determinants of both brachial and carotid systolic BP included arterial stiffness as measured by aortic pulse wave velocity, stroke volume (via echocardiography), arterial wave reflection, left ventricular ejection time, and upstroke time. The strongest influence was exerted by arterial stiffness...
August 20, 2016: Journal of Clinical Hypertension
Kirsten Bibbins-Domingo, David C Grossman, Susan J Curry, Karina W Davidson, John W Epling, Francisco A R García, Matthew W Gillman, Alex R Kemper, Alex H Krist, Ann E Kurth, C Seth Landefeld, Michael LeFevre, Carol M Mangione, Douglas K Owens, William R Phillips, Maureen G Phipps, Michael P Pignone, Albert L Siu
IMPORTANCE: Elevations in levels of total, low-density lipoprotein, and non-high-density lipoprotein cholesterol; lower levels of high-density lipoprotein cholesterol; and, to a lesser extent, elevated triglyceride levels are associated with risk of cardiovascular disease in adults. OBJECTIVE: To update the 2007 US Preventive Services Task Force (USPSTF) recommendation on screening for lipid disorders in children, adolescents, and young adults. EVIDENCE REVIEW: The USPSTF reviewed the evidence on screening for lipid disorders in children and adolescents 20 years or younger--1 review focused on screening for heterozygous familial hypercholesterolemia, and 1 review focused on screening for multifactorial dyslipidemia...
August 9, 2016: JAMA: the Journal of the American Medical Association
Sheree M Schrager, Kimberly C Arthur, Justine Nelson, Anne R Edwards, J Michael Murphy, Rita Mangione-Smith, Alex Y Chen
OBJECTIVES: We sought to develop and validate a method to identify social complexity risk factors (eg, limited English proficiency) using Minnesota state administrative data. A secondary objective was to examine the relationship between social complexity and caregiver-reported need for care coordination. METHODS: A total of 460 caregivers of children with noncomplex chronic conditions enrolled in a Minnesota public health care program were surveyed and administrative data on these caregivers and children were obtained...
September 2016: Pediatrics
J J Stirnemann, N Fries, R Bessis, M Fontanges, R Mangione, L J Salomon
OBJECTIVE: To assess potential differences in fetal size between the French population and the international population from the INTERGROWTH-21(st) (IG) project and to measure the impact of switching to the IG references for fetal size. DESIGN AND SETTING: Nationwide cross-sectional study of fetal ultrasound biometry. POPULATION: Low-risk pregnancies prospectively recruited within the network of the national French college of fetal ultrasound over a 6 week-period...
August 12, 2016: Ultrasound in Obstetrics & Gynecology
Simona Todaro, Maria Antonietta Sabatino, Maria Rosalia Mangione, Pasquale Picone, Maria Laura Di Giacinto, Donatella Bulone, Clelia Dispenza
Partially degalactosylated xyloglucan from tamarind seeds (Deg-XG) is a very appealing biopolymer for the production of in situ gelling systems at physiological temperature. In this work, we observe that the morphology of hydrogels evolves towards high degrees of structural organization with time, yielding to dense stacks of thin membranes within 24h of incubation at 37°C. We also explore the possibility offered by gamma irradiation of controlling the time scale of this phenomenon, the final morphology and mechanical properties of the system...
November 5, 2016: Carbohydrate Polymers
Kenneth Mangion, David Carrick, Barry W Hennigan, Alexander R Payne, John McClure, Maureen Mason, Rajiv Das, Rebecca Wilson, Richard J Edwards, Mark C Petrie, Margaret McEntegart, Hany Eteiba, Keith G Oldroyd, Colin Berry
OBJECTIVE: We hypothesised that, compared with culprit-only primary percutaneous coronary intervention (PCI), additional preventive PCI in selected patients with ST-elevation myocardial infarction with multivessel disease would not be associated with iatrogenic myocardial infarction, and would be associated with reductions in left ventricular (LV) volumes in the longer term. METHODS: In the preventive angioplasty in myocardial infarction trial (PRAMI; ISRCTN73028481), cardiac magnetic resonance (CMR) was prespecified in two centres and performed (median, IQR) 3 (1, 5) and 209 (189, 957) days after primary PCI...
August 8, 2016: Heart: Official Journal of the British Cardiac Society
Elaine Rutherford, Mohammed A Talle, Kenneth Mangion, Elizabeth Bell, Samuli M Rauhalammi, Giles Roditi, Christie McComb, Aleksandra Radjenovic, Paul Welsh, Rosemary Woodward, Allan D Struthers, Alan G Jardine, Rajan K Patel, Colin Berry, Patrick B Mark
Noninvasive quantification of myocardial fibrosis in end-stage renal disease is challenging. Gadolinium contrast agents previously used for cardiac magnetic resonance imaging (MRI) are contraindicated because of an association with nephrogenic systemic fibrosis. In other populations, increased myocardial native T1 times on cardiac MRI have been shown to be a surrogate marker of myocardial fibrosis. We applied this method to 33 incident hemodialysis patients and 28 age- and sex-matched healthy volunteers who underwent MRI at 3...
October 2016: Kidney International
Fernando L M Bernardi, Henrique B Ribeiro, Luiz A Carvalho, Rogerio Sarmento-Leite, José A Mangione, Pedro A Lemos, Alexandre Abizaid, Eberhard Grube, Josep Rodés-Cabau, Fábio S de Brito
BACKGROUND: Direct transcatheter aortic valve replacement (TAVR) is regarded as having potential advantages over TAVR with balloon aortic valve predilatation (BAVP) in reducing procedural complications, but there are few data to support this approach. METHODS AND RESULTS: Patients included in the Brazilian TAVR registry with CoreValve and Sapien-XT prosthesis were compared according to the implantation technique, with or without BAVP. Clinical and echocardiographic data were analyzed in overall population and after propensity score matching...
August 2016: Circulation. Cardiovascular Interventions
Arti D Desai, Q Burkhart, Layla Parast, Tamara D Simon, Carolyn Allshouse, Maria T Britto, JoAnna K Leyenaar, Courtney A Gidengil, Sara L Toomey, Marc N Elliott, Eric C Schneider, Rita Mangione-Smith
BACKGROUND AND OBJECTIVES: Few measures exist to assess pediatric transition quality between care settings. The study objective was to develop and pilot test caregiver-reported quality measures for pediatric hospital- and emergency department (ED)-to-home transitions. METHODS: Based on an evidence review, we developed draft caregiver-reported quality measures for transitions between sites of care. Using the RAND-UCLA modified Delphi method, a multi-stakeholder panel endorsed measures for further development...
August 2, 2016: Academic Pediatrics
Rachel Xuereb, Caroline J Magri, Sara Xuereb, Mariosa Xuereb, Marion Zammit Mangion, Robert G Xuereb
Despite a generalized belief that women are protected from cardiovascular disease, this remains the leading cause of death in women. This review focuses on differences in symptomatology, diagnostic modalities and therapeutic strategies in women with regard to cardiovascular disease.
August 2, 2016: British Journal of Hospital Medicine
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