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https://www.readbyqxmd.com/read/28528008/-role-of-therapeutic-drug-monitoring-in-pulmonary-infections
#1
REVIEW
C Padoin
Pulmonary infections are common and caused by a wide range of viruses, bacteria, parasites and fungi. They consist of lower respiratory tract infections with community and hospital acquired acute pneumonia, bronchitis, lung abscess, fungal infections and tuberculosis. The management of these infections should be based on guidelines that take into account the microorganisms most frequently involved as a basis for empirical treatment, with identification of causative microorganisms allowing targeted treatments...
May 17, 2017: Revue des Maladies Respiratoires
https://www.readbyqxmd.com/read/28527286/-possible-oral-transmission-of-chagas-disease-among-hydrocarbons-sector-workers-in-casanare-colombia-2014
#2
Liliana Patricia Zuleta-Dueñas, Ángela Johana López-Quiroga, Fernando Torres-Torres, Oneida Castañeda-Porras
INTRODUCTION: Trypanosoma cruzi, the etiological agent for Chagas disease, can be transmitted by oral intake of contaminated food or drinks. During epidemiological week 14 of 2014, two cases of acute Chagas disease were notified among hydrocarbons sector workers in Paz de Ariporo, Casanare. OBJECTIVE: To characterize the affected population, to establish control and prevention measures and to confirm the outbreak. MATERIALS AND METHODS: We conducted an outbreak investigation that included the following components: a) Search for symptomatic people compatible with Chagas disease according to the case definition for their referral to medical services; b) entomological survey (192/197 houses); c) sanitary inspection and microbiological analysis of food samples; and d) study of reservoirs...
June 1, 2017: Biomédica: Revista del Instituto Nacional de Salud
https://www.readbyqxmd.com/read/28516820/blogging-in-infectious-diseases-and-clinical-microbiology-assessment-of-blogosphere-content
#3
Gabriel Birgand, Rachael Troughton, Luke S P Moore, Esmita Charani, Timothy M Rawson, Enrique Castro-Sánchez, Alison H Holmes
OBJECTIVE To analyze influential infectious diseases, antimicrobial stewardship, infection control, or medical microbiology blogs and bloggers SETTING World wide web DESIGN We conducted a systematic search for blogs in accordance with the PRISMA guidelines in September 2015. METHODS A snowball sampling approach was applied to identify blogs using various search engines. Blogs were eligible if they (1) focused on infectious diseases, antimicrobial stewardship, infection control, or medical microbiology; (2) were intended for health professionals; and (3) were written in English and (4) were updated regularly...
May 18, 2017: Infection Control and Hospital Epidemiology
https://www.readbyqxmd.com/read/28513490/coexistence-of-herpes-simplex-virus-infection-in-microsporidial-stromal-keratitis-associated-with-granulomatous-inflammation
#4
Ruchi Mittal, Praveen K Balne, Srikant Sahu, Sujata Das, Savitri Sharma
BACKGROUND: Microsporidial stromal keratitis poses several diagnostic challenges. Patients may present with corneal ulceration, marked stromal thinning, or even as a quite corneal scar. The presentation of microsporidial stromal keratitis commonly mimics viral keratitis. Microbiology scrapings are usually helpful; however, scraping and culture-negative cases pose a significant diagnostic dilemma. Histopathological examination is diagnostic but shows varying degree of inflammation, predominantly composed of polymorphonuclear leukocytes...
April 2017: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/28511414/a-community-based-study-on-pelvic-inflammatory-disease-in-postmenopausal-females-microbiological-spectrum-and-socio-demographic-correlates
#5
Samreen Khan, M Athar Ansari, Shaista M Vasenwala, Zehra Mohsin
INTRODUCTION: Pelvic Inflammatory Disease (PID) is a common and serious complication of sexually transmitted diseases in young women but is rarely diagnosed in the postmenopausal women. Very few studies have been done regarding post-menopausal PID. AIM: To determine the burden of PID, associated micro-organisms, pathophysiology and risk factors among post-menopausal women of the community. MATERIALS AND METHODS: A cross-sectional study was conducted among 530 post-menopausal women in the registered field practice areas of the JN Medical College and Hospital, Aligarh, Uttar Pradesh, India...
March 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28511383/study-on-mics-of-tigecycline-in-clinical-isolates-of-carbapenem-resistant-enterobacteriaceae-cre-at-a-tertiary-care-centre-in-north-india
#6
Vineeta Khare, Prashant Gupta, Fareya Haider, Rehana Begum
INTRODUCTION: Members of family Enterobacteriaceae are the most common Gram-negative bacteria isolated from clinical samples. Those Enterobacteriaceae which have acquired resistance to all β-lactams antibiotics including the carbapenems are considered as Carbapenem Resistant Enterobacteriaceae (CRE). These CRE isolates are often resistant to most other classes of antimicrobials as well, making their treatment a great challenge. Tigecycline is one of the last resort antimicrobials against such multidrug resistant bacteria...
March 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28511381/prevalence-of-carbapenem-resistant-non-fermenting-gram-negative-bacterial-infection-and-identification-of-carbapenemase-producing-nfgnb-isolates-by-simple-phenotypic-tests
#7
Jane Esther, Diego Edwin, Uma
INTRODUCTION: Non-Fermenting Gram negative bacilli (NFGNB) are emerging multi-drug resistant pathogens causing nosocomial infections. In recent years, carbapenem resistance in NFGNB has increased due to a variety of drug resistance mechanisms, the most common being production of carbapenemases. AIM: To detect carbapenemase and metallo-β-lactamase (MBL) production in NFGNBs by four phenotypic tests and to compare the various phenotypic methods for detection of carbapenemase and MBL production in nosocomial NFGNB isolates...
March 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28511379/malassezia-yeast-and-cytokine-gene-polymorphism-in-atopic-dermatitis
#8
Charu Jain, Shukla Das, V G Ramachandran, Rumpa Saha, S N Bhattacharya, Sajad Dar
INTRODUCTION: Atopic Dermatitis (AD) is a recurrent chronic condition associated with microorganism and their interaction with the susceptible host. Malassezia yeast is a known commensal which is thought to provoke the recurrent episodes of symptoms in atopic dermatitis patients. Malassezia immunomodulatory properties along with defective skin barrier in such host, results in disease manifestation. Here, we studied Single Nucleotide Polymorphism (SNP) in IL10 and IFN γ genes of the host and its relation with susceptibility to Malassezia infection...
March 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28497502/improving-outcome-of-fungal-diseases-guiding-experts-and-patients-towards-excellence
#9
Oliver A Cornely, Cornelia Lass-Flörl, Katrien Lagrou, Valentina Arsic-Arsenijevic, Martin Hoenigl
Invasive fungal infections are on the rise and during recent years understanding the epidemiology of fungal infections improved. Over 1 billion people are affected and 25 million patients are at imminent risk of severe organ damage or death due to fungal infection. The European Confederation of Medical Mycology (ECMM), founded in 1993, is the roof organisation of 23 National Medical Mycology Societies in Europe. ECMM fights fungal infections at various levels, by creating and distributing scientific knowledge and promoting scientific exchange...
May 12, 2017: Mycoses
https://www.readbyqxmd.com/read/28497161/outcomes-in-diabetic-foot-ulcer-patients-with-isolated-t2-marrow-signal-abnormality-in-the-underlying-bone-should-the-diagnosis-of-osteitis-be-changed-to-early-osteomyelitis
#10
Dennis Duryea, Stephanie Bernard, Donald Flemming, Eric Walker, Cristy French
OBJECTIVE: To evaluate the variability of clinical treatment and outcomes based on reporting of diabetic foot ulcer MRI findings of adjacent marrow T2 hyperintensity with normal T1 signal. MATERIALS AND METHODS: A retrospective review was conducted of 46 MRI examinations evaluating diabetic foot ulcers that demonstrated normal T1 marrow signal, but T2 marrow hyperintensity deep to the ulcer. The cohort was divided based on MRI report impressions into three groups; "osteitis without osteomyelitis" (OW), "osteitis but cannot exclude early osteomyelitis" (OCEO) and "early osteomyelitis" (EO)...
May 11, 2017: Skeletal Radiology
https://www.readbyqxmd.com/read/28496492/infective-endocarditis-report-from-a-main-referral-teaching-hospital-in-iran
#11
Behrooz Heydari, Iman Karimzadeh, Hossein Khalili, Esfandiar Shojaei, Abdolrasool Ebrahimi
BACKGROUND/OBJECTIVE: The aim of the present preliminary study was to assess the demographic, clinical, paraclinical, microbiological, echocardiographic, and therapeutic profile as well as in-hospital outcome of patients with infective endocarditis at a referral center for various infectious diseases in Iran. METHODS: Required demographic, clinical, plausible complications and paraclinical data were collected from patients' medical charts. Echocardiographic findings were obtained by performing transthoracic and/or transesophageal echocardiography as clinically indicated...
2017: Iranian Journal of Pharmaceutical Research: IJPR
https://www.readbyqxmd.com/read/28495072/reprint-of-application-of-next-generation-sequencing-in-clinical-microbiology-and-infection-prevention
#12
Ruud H Deurenberg, Erik Bathoorn, Monika A Chlebowicz, Natacha Couto, Mithila Ferdous, Silvia García-Cobos, Anna M D Kooistra-Smid, Erwin C Raangs, Sigrid Rosema, Alida C M Veloo, Kai Zhou, Alexander W Friedrich, John W A Rossen
Current molecular diagnostics of human pathogens provide limited information that is often not sufficient for outbreak and transmission investigation. Next generation sequencing (NGS) determines the DNA sequence of a complete bacterial genome in a single sequence run, and from these data, information on resistance and virulence, as well as information for typing is obtained, useful for outbreak investigation. The obtained genome data can be further used for the development of an outbreak-specific screening test...
May 8, 2017: Journal of Biotechnology
https://www.readbyqxmd.com/read/28492472/molecular-surveillance-of-cronobacter-spp-isolated-from-a-wide-variety-of-foods-from-44-different-countries-by-sequence-typing-of-16s-rrna-rpob-and-o-antigen-genes
#13
Nancy Miranda, Pratik Banerjee, Steven Simpson, Khalil Kerdahi, Irshad M Sulaiman
Cronobacter spp. are emerging infectious bacteria that can cause acute meningitis and necrotizing enterocolitis in neonatal and immunocompromised individuals. Although this opportunistic human-pathogenic microorganism has been isolated from a wide variety of food and environmental samples, it has been primarily linked to foodborne outbreaks associated with powdered infant formula. The U.S. Food and Drug Administration use the presence of these microbes as one of the criteria to assess food adulteration and to implement regulatory actions...
May 11, 2017: Foods (Basel, Switzerland)
https://www.readbyqxmd.com/read/28491303/self-evaluation-of-tobacco-exposure-by-allied-health-students-in-a-community-college-setting
#14
Fiona Geiser, Meredith Much, Karen Beyer
OBJECTIVE: Tobacco education is among the initiatives encouraged for health professionals to help them appreciate the significance of addressing tobacco use among their patients. In this pilot study, a nicotine biomarker (cotinine) study was introduced to an applied microbiology course required of all allied health students. Participants assessed their own smoking status in the previous 24 h using a two-dimensional experimental design of a questionnaire and rapid urinary cotinine immunoassay...
2017: SAGE Open Medicine
https://www.readbyqxmd.com/read/28479689/detection-of-microorganisms-on-formalin-fixed-and-stored-pathology-tissues-a-microbiological-study
#15
Gayathri Ramesh, Anuradha Katiyar, Ramamurthy Sujatha, Amrita Raj, Bhavana Gupta, Amit Kumar
BACKGROUND: Formalin is widely used to fix histological preparations and as preservatives in embalming solutions and is an age-long practice in medical laboratories. It is generally accepted that the risk of contracting infections is relatively high among medical laboratory workers and pathologists. Recent studies have, however, suggested that formalin does not effectively inactivate all kinds of microbes in formalin-fixed tissue (FFT). Long time preserved tissues in formalin may develop growth of microbes on the surface of the formalin...
January 2017: Journal of Oral and Maxillofacial Pathology: JOMFP
https://www.readbyqxmd.com/read/28473912/high-burden-of-carbapenem-resistant-enterobacteriaceae-cre-fecal-carriage-at-a-teaching-hospital-cost-effectiveness-of-screening-in-low-resource-setting
#16
Abdul Rahman Zaidah, Nurul Izzah Mohammad, Siti Suraiya, Azian Harun
BACKGROUND: Infections by multidrug-resistant gram-negative bacteria (MDR-GNB) have been continuously growing and pose challenge to health institution globally. Carbapenem-resistant Enterobacteriacea (CRE) was identified as one of the MDR-GNB which has limited treatment options and higher mortality compared to those of sensitive strains. We report an increased burden of CRE fecal carriage at a hospital in the North-eastern region of Malaysia. METHODS: A retrospective descriptive study from August 2013 to December 2015 was conducted in the Medical Microbiology & Parasitology laboratory of Hospital Universiti Sains Malaysia, which is a tertiary teaching hospital with more than 700 beds...
2017: Antimicrobial Resistance and Infection Control
https://www.readbyqxmd.com/read/28470636/-antibiotic-stewardship-from-bench-to-bedside
#17
Jan R Ortlepp
The article explains the practical implementation of Antibiotic Stewardship (ABS) in the clinic. With increasing prevalence of resistant bacteria, the medical profession is challenged to critically question and reduce antibiotic prescriptions. ABS programs are designed to support this. In particular, the involvement of clinic management in the ABS has to improve. There has to be a greater awareness of problems associated with antibiotic use and the data about it must be communicated transparently within the hospital...
April 2017: Anästhesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie: AINS
https://www.readbyqxmd.com/read/28470191/medical-research-pitching-the-big-tent-of-modern-microbiology
#18
Andrew Jermy
No abstract text is available yet for this article.
May 3, 2017: Nature
https://www.readbyqxmd.com/read/28469373/the-use-of-next-generation-sequencing-in-the-identification-of-a-fastidious-pathogen-a-lesson-from-a-clinical-setup
#19
Amr Tm Saeb, Mohamed Abouelhoda, Manojkumar Selvaraju, Sahar I Althawadi, Maysoon Mutabagani, Mohammad Adil, Abdullah Al Hokail, Hamsa T Tayeb
Clostridium haemolyticum is the causal agent of bacillary hemoglobinuria in cattle, goat, sheep, and ruminants. In this study, we report the first recorded human-infecting C. haemolyticum strain collected from an 18-year-old woman diagnosed with acute lymphoblastic leukemia. After failure of traditional techniques, only next-generation sequencing (NGS) technology in combination with bioinformatics, phylogenetic, and pathogenomics analyses revealed that our King Faisal Specialist Hospital and Research Center (KFSHRC) bacterial isolate belongs to C...
2017: Evolutionary Bioinformatics Online
https://www.readbyqxmd.com/read/28462910/optimum-silicon-doping-of-carbon-coatings-by-pulsed-laser-technique-for-superior-functional-biomedical-surfaces-fabrication
#20
Ion N Mihailescu, Dorota Bociaga, Gianina Popescu-Pelin, George Stan, Liviu Duta, Gabriel Socol, Carmen Chifiriuc, Coralia Bleotu, Veronica Lazar, Marius-Adrian Husanu, Irina Zgura, Florin Miculescu, Irina Negut, Claudiu Hapenciuc
We report on the fabrication of Silicon (Si) doped Carbon (C) [C:Si] structures by combinatorial pulsed laser deposition to identify the best design for a novel generation of multi-functional coated implants. The synthesized films were characterized from the morphological, structural, compositional, mechanical and microbiological points of view. Scanning Electron Microscopy investigation highlighted the presence, on top of the deposited layers, of spheroid particulates with sizes in the micron range. No micro-cracks or delaminations were observed...
May 2, 2017: Biofabrication
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