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neuropeptide y

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https://www.readbyqxmd.com/read/28427990/neuropeptide-y-not-involved-in-cutaneous-vascular-control-in-young-human-females-taking-oral-contraceptive-hormones
#1
Gary J Hodges, Zachary T Martin, Andrew T Del Pozzi
We previously reported that the cutaneous vasodilator response to local warming in males required noradrenaline (NA) and neuropeptide-Y (NPY). Animal work has shown no role for NPY in female vascular control. We investigated the contribution of NA and NPY in human female cutaneous vascular control. Nine female and nine male participants volunteered. To elucidate whether synthetic oestrogen and progesterone altered cutaneous vascular responses, females were tested in high-hormone (HH) and low-hormone (LH) phases of oral contraceptive pill (OCP)...
April 18, 2017: Microvascular Research
https://www.readbyqxmd.com/read/28424580/the-role-of-microrna-in-the-modulation-of-the-melanocortinergic-system
#2
REVIEW
Adel Derghal, Mehdi Djelloul, Jérôme Trouslard, Lourdes Mounien
The central control of energy balance involves a highly regulated neuronal network within the hypothalamus and the dorsal vagal complex. In these structures, pro-opiomelanocortin (POMC) neurons are known to reduce meal size and to increase energy expenditure. In addition, leptin, a peripheral signal that relays information regarding body fat content, modulates the activity of melanocortin pathway neurons including POMC-, Agouti-related peptide (AgRP)/Neuropeptide Y (NPY)-, melanocortin receptors (MC3R and MC4R)-expressing neurons...
2017: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/28423914/current-views-on-neuropeptide-y-and-diabetes-related-atherosclerosis
#3
Wei-Wei Sun, Ping Zhu, Yan-Chuan Shi, Chen-Liang Zhang, Xu-Feng Huang, Shi-Yu Liang, Zhi-Yuan Song, Shu Lin
Diabetes-induced atherosclerotic cardiovascular disease is the leading cause of death of diabetic patients. Neuronal regulation plays a critical role in glucose metabolism and cardiovascular function under physiological and pathological conditions, among which, neurotransmitter neuropeptide Y has been shown to be closely involved in these two processes. Elevated central neuropeptide Y level promotes food intake and reduces energy expenditure, thereby increasing adiposity. Neuropeptide Y is co-localized with noradrenaline in central and sympathetic nervous systems...
April 1, 2017: Diabetes & Vascular Disease Research
https://www.readbyqxmd.com/read/28420957/neuropeptide-y-induced-orexigenic-action-is-attenuated-by-the-orexin-receptor-antagonist-in-bullfrog-larvae
#4
Kouhei Matsuda, Kairi Matsumura, Syun-Suke Shimizu, Tomoya Nakamachi, Norifumi Konno
In bullfrog larvae at the pre- and pro-metamorphic stages, feeding behavior is regulated by appetite factors such as orexigenic peptides. In fact, food intake is enhanced by intracerebroventricular (ICV) administration of neuropeptide Y (NPY) and orexin A. Using goldfish, our previous study indicated that the orexigenic action of NPY is mediated by orexin A, suggesting the functional interaction between the two. However, there is little information about whether the action of orexin A mediates the orexigenic action of NPY in bullfrog larvae...
2017: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/28418087/traumatic-stress-induced-persistent-changes-in-dna-methylation-regulate-neuropeptide-y-expression-in-rat-jejunum
#5
S Sagarkar, S Mahajan, A G Choudhary, C D Borkar, D M Kokare, A J Sakharkar
BACKGROUND: Stress-induced chronic neuropsychiatric conditions such as anxiety are often co-morbid with gastrointestinal malfunctions. While we find enduring anxiety-like symptoms following minimal traumatic brain injury (MTBI) in rats, gastrointestinal consequences of MTBI remain elusive. METHODS: In this study, we examined the effects of MTBI on a major gut peptide, neuropeptide Y (NPY) and gut motility. DNA methylation was studied as a possible epigenetic mechanism operative in the regulation of NPY expression in the gut...
April 18, 2017: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
https://www.readbyqxmd.com/read/28413811/cell-surface-protein-detection-to-assess-receptor-internalization
#6
Magdalena Czarnecka, Joanna Kitlinska
The migration of membrane receptors upon exposure to different stimulants/inhibitors is of great importance. Among others, the internalization of membrane receptors affects their accessibility to ligands and cell responsiveness to environmental cues. Experimentally, receptor internalization can be used as a measure of their activation. In our studies, we employed this approach to explore cross-talk between a seven transmembrane domain receptor for neuropeptide Y (NPY), Y5R, and a tyrosine kinase receptor for brain-derived neurotrophic factor (BDNF), TrkB...
October 20, 2016: Bio-protocol
https://www.readbyqxmd.com/read/28411439/neuropeptide-y-enhances-proliferation-and-prevents-apoptosis-in-rat-bone-marrow-stromal-cells-in-association-with-activation-of-the-wnt-%C3%AE-catenin-pathway-in-vitro
#7
Jianqun Wu, Song Liu, Huan Meng, Tianyu Qu, Su Fu, Zhao Wang, Jianguo Yang, Dan Jin, Bin Yu
Neuropeptide Y (NPY) exhibits a critical but poorly understood regulatory signaling function and has been shown to promote proliferation, vascularization and migration in several types of cells and tissues. However, little is known about the specific role of NPY in the proliferation and apoptosis of bone marrow stromal cells (also known as bone marrow-derived mesenchymal stem cells, BMSCs), which contain a subpopulation of multipotent skeletal stem cells. Based on BrdU incorporation tests, Cell Counting Kit-8, flow cytometry, quantitative polymerase chain reaction and western blotting, we showed that NPY significantly promoted the proliferation of BMSCs in a concentration-dependent manner, with a maximal effect observed at a concentration of 10(-10)M for pro-proliferative and 10(-12)M for anti-apoptotic activities...
April 5, 2017: Stem Cell Research
https://www.readbyqxmd.com/read/28398010/effects-of-drugs-of-abuse-on-the-central-neuropeptide-y-system
#8
(no author information available yet)
No abstract text is available yet for this article.
May 2017: Addiction Biology
https://www.readbyqxmd.com/read/28392070/respiratory-network-stability-and-modulatory-response-to-substance-p-require-nalcn
#9
Szu-Ying Yeh, Wei-Hsiang Huang, Wei Wang, Christopher S Ward, Eugene S Chao, Zhenyu Wu, Bin Tang, Jianrong Tang, Jenny J Sun, Meike Esther van der Heijden, Paul A Gray, Mingshan Xue, Russell S Ray, Dejian Ren, Huda Y Zoghbi
Respiration is a rhythmic activity as well as one that requires responsiveness to internal and external circumstances; both the rhythm and neuromodulatory responses of breathing are controlled by brainstem neurons in the preBötzinger complex (preBötC) and the retrotrapezoid nucleus (RTN), but the specific ion channels essential to these activities remain to be identified. Because deficiency of sodium leak channel, non-selective (Nalcn) causes lethal apnea in humans and mice, we investigated Nalcn function in these neuronal groups...
April 19, 2017: Neuron
https://www.readbyqxmd.com/read/28386846/different-effects-of-neuropeptide-y-on-proliferation-of-vascular-smooth-muscle-cells-via-regulation-of-geminin
#10
Zhou-Qin Jiang, You-Li Zhou, Xia Chen, Lin-Yu Li, Shi-Yu Liang, Shu Lin, Mao-Qin Shu
The proliferation-promoting effect of neuropeptide Y (NPY) always functions in low-serum-cultured vascular smooth muscle cells (VSMCs), and the phenotypic switch of VSMCs is regulated by concentrations of serum. Whether the property of the NPY proliferative effect in VSMCs relies on phenotype of VSMCs is unclear. We aimed to explore the role of NPY on proliferation of different VSMC phenotypes in the pathogenesis of atherosclerosis. By stimulating A10 cells with 200 nM NPY in 0.5 or 10% serum, 3H-thymidine and 5-ethynyl-2'-deoxyuridine (EdU) and CCK8 measurements were used to detect VSMC proliferation...
April 6, 2017: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/28380517/surface-wetting-strategy-prevents-acute-heat-exposure-induced-alterations-of-hypothalamic-stress-and-metabolic-related-genes-in-broiler-chickens
#11
H Rajaei-Sharifabadi, E Greene, A Piekarski, D Falcon, L Ellestad, A Donoghue, W Bottje, T Porter, Y Liang, S Dridi
Heat stress (HS) is devastating to poultry production worldwide, yet its biology and molecular responses are not well defined. Although advances in management strategy have partially alleviated the negative impact of HS, productivity still continues to decline when the ambient temperature rises. Therefore, identifying mechanism-based approaches to decrease HS susceptibility while improving production traits is critical. Recently, we made a breakthrough by applying a surface wetting strategy and showing that it improves growth performance compared with the current conventional cooling system...
March 2017: Journal of Animal Science
https://www.readbyqxmd.com/read/28377876/cannabinoid-type-1-receptor-containing-axons-innervate-npy-agrp-neurons-in-the-mouse-arcuate-nucleus
#12
Yury M Morozov, Marco Koch, Pasko Rakic, Tamas L Horvath
OBJECTIVES: Phytocannabinoids, such as THC and endocannabinoids, are well known to promote feeding behavior and to control energy metabolism through cannabinoid type 1 receptors (CB1R). However, the underlying mechanisms are not fully understood. Generally, cannabinoid-conducted retrograde dis-inhibition of hunger-promoting neurons has been suggested to promote food intake, but so far it has not been demonstrated due to technical limitations. METHODS: We applied immunohistochemical labeling of CB1R for light microscopy and electron microscopy combined with three-dimensional reconstruction from serial sections in CB1R-expressing and CB1R-null mice, which served as a negative control...
April 2017: Molecular Metabolism
https://www.readbyqxmd.com/read/28377324/dcf1-regulates-neuropeptide-expression-and-maintains-energy-balance
#13
Qiang Liu, Yu Chen, Qian Li, Liang Wu, Tieqiao Wen
Neuropeptide Y (NPY) is an important neurotransmitter in the brain that plays a pivotal role in food intake and energy storage. Although many studies have focused on these functions, the regulation of NPY expression remains unclear. Here we showed that dendritic cell factor 1 (Dcf1) regulates NPY expression and maintains energy balance. We found that NPY expression is significantly reduced in the hypothalamus of Dcf1 knockout (Dcf1(-/-), KO) mice. In contrast, Dcf1 overexpression significantly increases NPY expression in the cell line...
April 1, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/28377124/characterization-of-appetite-regulating-factors-in-platyfish-xiphophorus-maculatus-cyprinodontiformes-poeciliidae
#14
Paul M Pitts, Hélène Volkoff
The regulation of energy in fish, like most vertebrates, is a complex process that involves a number of brain and peripheral hormones. These signals include anorexigenic (e.g. cholecystokinin (CCK) and cocaine- and amphetamine-regulated transcript (CART)) as well as orexigenic (e.g. orexin and neuropeptide Y (NPY)) peptides. Platyfish, Xiphophorus maculatus, are freshwater viviparous fish for which little is known about the endocrine mechanisms regulating feeding. In order to elucidate the role of these peptides in the regulation of feeding of platyfish, we examined the effects of peripheral injections of CCK and orexin on feeding behavior and food intake...
April 3, 2017: Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology
https://www.readbyqxmd.com/read/28373831/interactions-of-circadian-rhythmicity-stress-and-orexigenic-neuropeptide-systems-implications-for-food-intake-control
#15
REVIEW
Anna Blasiak, Andrew L Gundlach, Grzegorz Hess, Marian H Lewandowski
Many physiological processes fluctuate throughout the day/night and daily fluctuations are observed in brain and peripheral levels of several hormones, neuropeptides and transmitters. In turn, mediators under the "control" of the "master biological clock" reciprocally influence its function. Dysregulation in the rhythmicity of hormone release as well as hormone receptor sensitivity and availability in different tissues, is a common risk-factor for multiple clinical conditions, including psychiatric and metabolic disorders...
2017: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/28370506/feeding-during-the-rest-phase-promotes-circadian-conflict-in-nuclei-that-control-energy-homeostasis-and-sleep-wake-cycle-in-rats
#16
Oscar Daniel Ramirez-Plascencia, Nadia Saderi, Carolina Escobar, Roberto Salgado-Delgado
Food intake during the rest phase promotes circadian desynchrony, which has been associated with metabolic diseases. However, the link between circadian and metabolic alterations is not well understood. To investigate this issue, we explored the circadian of c-Fos immunoreactivity in rats fed during the day, during the night or with free access to food for three weeks. The analysis was focused on the hypothalamic nuclei, which are interconnected and involved in the control of energy homeostasis and/or arousal: the lateral hypothalamic (LH) and perifornical areas (PeF), the arcuate (ARC), ventrolateral preoptic (VLPO) and tuberomammilary nuclei...
March 28, 2017: European Journal of Neuroscience
https://www.readbyqxmd.com/read/28361739/ghrelin-activation-and-neuropeptide-y-elevation-in-response-to-medium-chain-triglyceride-administration-in-anorexia-nervosa-patients
#17
Keisuke Kawai, Megumi Nakashima, Masayasu Kojima, Sakino Yamashita, Shu Takakura, Miki Shimizu, Chiharu Kubo, Nobuyuki Sudo
BACKGROUND & AIMS: Ghrelin, a peptide found in the stomach, increases appetite and fat-free mass while suppressing energy expenditure. Ghrelin requires modification by medium-chain triglycerides (MCTs) to exert its physiological effects. In this study, we investigated ghrelin activation and the resulting physiological changes following MCT administration. METHODS: Thirty participants were selected from among inpatients diagnosed with anorexia nervosa (AN). The patients were randomly divided into three groups by the MCT content of their nutritional supplement: (1) 'MCT high' (>6 g/day), (2) 'MCT moderate' (1-6 g/day), and (3) 'MCT low' (<1 g/day)...
February 2017: Clinical Nutrition ESPEN
https://www.readbyqxmd.com/read/28360786/interaction-of-cocaine-and-amphetamine-regulated-transcript-and-neuropeptide-y-on-behavior-in-the-central-nervous-system
#18
Aynur Müdüroğlu Kirmizibekmez, Murat Mengi, Ertan Yurdakoş
INTRODUCTION: In the central nervous system, cocaine- and amphetamine-regulated transcript (CART) 55-102 peptide is localized in areas, such as the ventral tegmental area, amygdala, hypothalamus, and hippocampus, where emotional activity is regulated. Studies on the effects of the intracerebroventricular (ICV) administration of CART peptide on behavior remain limited. The findings from these studies suggest that this neuropeptide has anxiogenic-like effects. In the central nervous system, neuropeptide Y (NPY) has similar localization as CART...
June 2016: Noro Psikiyatri Arsivi
https://www.readbyqxmd.com/read/28359084/genetic-evidence-for-multifactorial-control-of-the-reproductive-axis-in-zebrafish
#19
Yun Liu, Haipei Tang, Rui Xie, Shuisheng Li, Xiaochun Liu, Haoran Lin, Yong Zhang, Christopher H K Cheng
It is generally believed that kisspeptin and gonadotropin-releasing hormone (GnRH) are required for reproduction in vertebrates. In this study, we generated gnrh3-null zebrafish and found that gnrh3 mutation did not impair gonad development and reproductive capacity. Moreover, zebrafish triple knockout mutant lacking gnrh3 and the 2 kiss1s genes undergo normal puberty and gonad maturation. The expression of follicle-stimulating hormone beta (fshβ) and luteinizing hormone beta (lhβ) was not significantly altered whereas the expression of neuropeptide Y (npy), tachykinin 3 (tac3), and secretogranin-II (sgII) was significantly increased in the triple knockout mutant, suggesting that compensation mechanisms exist to stimulate the reproductive axis in the absence of kiss and gnrh...
March 1, 2017: Endocrinology
https://www.readbyqxmd.com/read/28358856/dexmedetomidine-ameliorates-muscle-wasting-and-attenuates-the-alteration-of-hypothalamic-neuropeptides-and-inflammation-in-endotoxemic-rats
#20
Minhua Cheng, Tao Gao, Fengchan Xi, Chun Cao, Yan Chen, Chenyan Zhao, Qiurong Li, Wenkui Yu
Dexmedetomidine is generally used for sedaton in critically ill, it could shorten duration of mechanical ventilation, ICU stay and lower basic metabolism. However, the exact mechanism of these positive effects remains unkown. Here we investigated the hypothesis that dexmedetomidine could ameliorate muscle wasting in endotoxemic rats and whether it was related to hypothalamic neuropeptides alteration and inflammation. Fourty-eight adult male Sprague-Dawley rats were intraperitoneally injected with lipopolysaccharide (LPS) (5 mg/kg) or saline, followed by 50 μg/kg dexmedetomidine or saline administration via the femoral vein catheter (infusion at 5 μg·kg-1·hr-1)...
2017: PloS One
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