Jakob Gleixner, Sergei Kopanchuk, Lukas Grätz, Maris-Johanna Tahk, Tõnis Laasfeld, Santa Veikšina, Carina Höring, Albert O Gattor, Laura J Humphrys, Christoph Müller, Nataliya Archipowa, Johannes Köckenberger, Markus R Heinrich, Roger Jan Kutta, Ago Rinken, Max Keller
The neuropeptide Y (NPY) Y4 receptor (Y4 R), a member of the family of NPY receptors, is physiologically activated by the linear 36-amino acid peptide pancreatic polypeptide (PP). The Y4 R is involved in the regulation of various biological processes, most importantly pancreatic secretion, gastrointestinal motility, and regulation of food intake. So far, Y4 R binding affinities have been mostly studied in radiochemical binding assays. Except for a few fluorescently labeled PP derivatives, fluorescence-tagged Y4 R ligands with high affinity have not been reported...
April 12, 2024: ACS Pharmacology & Translational Science