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https://www.readbyqxmd.com/read/28932345/the-grass-pollen-season-2015-a-proof-of-concept-multi-approach-study-in-three-different-european-cities
#1
Maximilian Kmenta, Katharina Bastl, Uwe Berger, Matthias F Kramer, Matthew D Heath, Sanna Pätsi, Anna-Mari Pessi, Annika Saarto, Barbora Werchan, Matthias Werchan, Reinhard Zetter, Karl-Christian Bergmann
BACKGROUND: Grasses release the most widespread aeroallergens with considerable sensitization rates, while different species produce several pollen concentration peaks throughout the season. This study analyzed the prevalence of grass species in three different European city areas and compared the flowering period of these species with daily pollen concentrations and the symptom loads of grass pollen allergy sufferers. METHODS: The most prevalent grass species in Vienna (Austria), Berlin (Germany) and Turku (Finland) were studied and examined by use of three different approaches: phenology, pollen monitoring and symptom load evaluation...
2017: World Allergy Organization Journal
https://www.readbyqxmd.com/read/28929740/use-of-mobile-device-data-to-better-estimate-dynamic-population-size-for-wastewater-based-epidemiology
#2
Kevin V Thomas, Arturo Amador, Jose Antonio Baz-Lomba, Malcolm Reid
Wastewater-based epidemiology is an established approach for quantifying community drug use and has recently been applied to estimate population exposure to contaminants such as pesticides and phthalate plasticizers. A major source of uncertainty in the population weighted biomarker loads generated is related to estimating the number of people present in a sewer catchment at the time of sample collection. Here, the population quantified from mobile device-based population activity patterns was used to provide dynamic population normalized loads of illicit drugs and pharmaceuticals during a known period of high net fluctuation in the catchment population...
September 20, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28929691/-deuterated-surrogate-and-uplc-ms-ms-method-for-simultaneous-determination-of-22-endocannabinoids-in-ovariectomized-rat-plasma
#3
Shi-Xie Xiang, Ying Xu, Jing-Jing Zhu, Zhi-Min Wang, Dong Zhang, Liang-Mian Chen, Wei-Hong Feng
A new method based on ultraperformance liquid chromatography-tandem mass spectrometry(UPLC-MS/MS) was developed for the simultaneous determination of 22 endocannabinoids(eCBs) and relevant compounds in ovariectomized rat plasma. After being extracted by solid-phase column(SPE), the plasma samples were detected by using UPLC-MS/MS. Analysis was carried out with ACQUITY UPLC BEH C₁₈ column. The mobile phase was 0.1% acetic acid solution(A)-acetonitrile and isopropanol(9∶1, B) for the gradient elution. In the positive ion multiple reaction monitoring(MRM) mode, deuterated reagents were taken as standard alternatives to calculate recoveries and simultaneously quantify 22 endocannabinoids...
November 2016: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/28929504/simultaneous-determination-of-serum-propafenone-and-its-metabolites-using-high-performance-liquid-chromatography
#4
Yuki Shirayama, Kosuke Doki, Yukio Sekiguchi, Kazutaka Aonuma, Yukinao Kohda, Masato Homma
Propafenone, a class Ic antiarrhythmic agent, is metabolized to 5-hydroxypropafeone (5-OHP) and N-depropylpropafenone (NDPP). Simultaneous determination of serum propafenone and its metabolites was performed using high-performance liquid chromatography (HPLC) equipped with a conventional octadecylsilyl silica column and ultraviolet detector. The wavelength was set at 250 nm. Propafenone and its metabolites in the serum were extracted using diethyl ether. The mobile phase solution, comprising 1-pentanesulfonic acid sodium salt (0...
September 19, 2017: Biomedical Chromatography: BMC
https://www.readbyqxmd.com/read/28927347/impact-of-spinal-rod-stiffness-on-porcine-lumbar-biomechanics-finite-element-model-validation-and-parametric-study
#5
Martin Brummund, Vladimir Brailovski, Yvan Petit, Yann Facchinello, Jean-Marc Mac-Thiong
A three-dimensional finite element model of the porcine lumbar spine (L1-L6) was used to assess the effect of spinal rod stiffness on lumbar biomechanics. The model was validated through a comparison with in vitro measurements performed on six porcine spine specimens. The validation metrics employed included intervertebral rotations and the nucleus pressure in the first instrumented intervertebral disc. The numerical results obtained suggest that rod stiffness values as low as 0.1 GPa are required to reduce the mobility gradient between the adjacent and instrumented segments and the nucleus pressures across the porcine lumbar spine significantly...
September 1, 2017: Proceedings of the Institution of Mechanical Engineers. Part H, Journal of Engineering in Medicine
https://www.readbyqxmd.com/read/28926856/positive-effects-of-promoting-physical-activity-and-balanced-diets-in-a-primary-school-setting-with-a-high-proportion-of-migrant-school-children
#6
Katharina S Weber, Olaf Spörkel, Melina Mertens, Alem Freese, Klaus Strassburger, Boris Kemper, Clemens Bachmann, Knut Diehlmann, Theodor Stemper, Anette E Buyken, Kerstin Ketelhut, Karsten Müssig
Background Children with migration background are at particular risk for overweight. We assessed the effects of a primary school-based initiative targeted at enhancing physical activity and dietary education among children with a high proportion of migration background. Methods Four 3(rd) and 4(th) grade classes (n=70 children, 77% with migration background) participated in a 10-months intervention comprising 2 additional exercise lessons weekly and 10 nutrition lessons per school year. 6 school classes (n=125 children, 65% with migration background) served as control...
September 2017: Experimental and Clinical Endocrinology & Diabetes
https://www.readbyqxmd.com/read/28926380/osseointegrated-transtibial-implants-in-patients-with-peripheral-vascular-disease-a-multicenter-case-series-of-5-patients-with-1-year-follow-up
#7
Robin Atallah, Jiao Jiao Li, William Lu, Ruud Leijendekkers, Jan Paul Frölke, Munjed Al Muderis
BACKGROUND: Osseointegration is an alternative treatment for amputees who are unable to wear or have difficulty wearing a socket prosthesis. Although the majority of limb amputations are due to vascular disease, such amputations have been perceived as a contraindication to osseointegration surgery. We report the outcomes of osseointegrated reconstruction in a series of 5 patients with limb amputation due to peripheral vascular disease. METHODS: Five patients with transtibial amputation and a history of peripheral vascular disease who received an osseointegration implant from 2014 to 2015 were followed for 12 months...
September 20, 2017: Journal of Bone and Joint Surgery. American Volume
https://www.readbyqxmd.com/read/28925418/mhealth-application-areas-and-technology-combinations-a-comparison-of-literature-from-high-and-low-middle-income-countries
#8
Haitham Abaza, Michael Marschollek
BACKGROUND: With the continuous and enormous spread of mobile technologies, mHealth has evolved as a new subfield of eHealth. While eHealth is broadly focused on information and communication technologies, mHealth seeks to explore more into mobile devices and wireless communication. Since mobile phone penetration has exceeded other infrastructure in low and middle-income countries (LMICs), mHealth is seen as a promising component to provide pervasive and patient-centered care. OBJECTIVES: The aim of our research work for this paper is to examine the mHealth literature to identify application areas, target diseases, and mHealth service and technology types that are most appropriate for LMICs...
August 8, 2017: Methods of Information in Medicine
https://www.readbyqxmd.com/read/28925264/space-environment-effects-on-flexible-low-voltage-organic-thin-film-transistors
#9
Laura Basiricò, Alberto Francesco Basile, Piero Cosseddu, Simone Gerardin, Tobias Cramer, Marta Bagatin, Andrea Ciavatti, Alessandro Paccagnella, Annalisa Bonfiglio, Beatrice Fraboni
Organic electronic devices fabricated on flexible substrates are promising candidates for applications in environments where flexible, light-weight and radiation hard materials are required. In this work, device parameters as threshold voltage, charge mobility and trap density of 13-Bis(triisopropylsilylethynyl)pentacene (TIPS-pentacene) based OTFTs have been monitored performing electrical measurements before and after irradiation by high-energy protons. The observed reduction of charge carrier mobility following irradiation can be only partially ascribed to the increased trap density...
September 19, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28923492/rationale-and-design-of-the-atrial-fibrillation-health-literacy-information-technology-trial-af-litt
#10
Emily N Guhl, Courtney L Schlusser, Lori E Henault, Timothy W Bickmore, Everlyne Kimani, Michael K Paasche-Orlow, Jared W Magnani
BACKGROUND: Atrial Fibrillation (AF) is a common cardiac arrhythmia that is challenging for patients and adversely impacts health-related quality of life (HRQoL). Long-term management of AF requires that patients adhere to complex therapies, understand difficult terminology, navigate subspecialty care, and have continued symptom monitoring with the goal of preventing adverse outcomes. Continued interventions to ameliorate the patient experience of AF are essential. DESIGN: The Atrial Fibrillation health Literacy Information Technology Trial (AF-LITT; NCT03093558) is an investigator-initiated, 2-arm randomized clinical trial (RCT)...
September 15, 2017: Contemporary Clinical Trials
https://www.readbyqxmd.com/read/28920550/sit-to-stand-activity-during-stroke-rehabilitation
#11
Andy Kerr, Jesse Dawson, Chris Robertson, Philip Rowe, Terence J Quinn
Objectives The sit to stand (STS) movement is key to independence and commonly affected by stroke. Repetitive practice is likely to improve STS ability during rehabilitation, however current practice levels are unknown. The objective of this study was simply to count the number of STS movements performed during the rehabilitation period of stroke patients using a physical activity monitor (PAM) and test whether being observed altered outcome. Methods Participants were medically stable patients referred for rehabilitation following stroke...
September 18, 2017: Topics in Stroke Rehabilitation
https://www.readbyqxmd.com/read/28919833/conventional-culture-versus-nucleic-acid-amplification-tests-for-screening-of-urethral-neisseria-gonorrhea-infection-among-asymptomatic-men-who-have-sex-with-men
#12
Jiratha Budkaew, Bandit Chumworathayi, Chamsai Pientong, Tipaya Ekalaksananan
BACKGROUND: Many methods are used to detect urethral Neisseria gonorrhea (NG) infection among asymptomatic men who have sex with men (MSM). The objective of this study was to define the performance of conventional culture compared to real-time polymerase chain reaction (PCR) for diagnosis of asymptomatic urethral gonorrhea among MSM. METHODS: In this cross-sectional study, 147 clinical specimens for NG testing from asymptomatic participants were evaluated. MSM >18 years old who consented to undergo urethral swab and collection of urine samples from two clinics (one was the sexually transmitted diseases (STDs) mobile clinic and the second was the antiretroviral clinic) located in Khon Kaen, Thailand, were recruited...
2017: Pragmatic and Observational Research
https://www.readbyqxmd.com/read/28918617/right-ventricular-thrombosis-combined-with-fetal-death-and-acrocyanosis-in-pregnancy
#13
Feridoun Sabzi, Aghigh Heidari
Prepartum or postpartum right ventricular thrombosis (RVT) is an exceedingly rare and potentially lethal phenomenon in pregnancy. We here report a case of a pregnant patient with near term pregnancy admitted for dyspnea, amniotic fluids discharge and labor pain in a gynecology center that an eight-month dead fetus was diagnosed and delivered vaginally by induction. A post delivery period was complicated by aggravation of her dyspnea and pleuritic chest pain that she referred for further evaluation in our cardiac center...
July 2017: Acta Medica Iranica
https://www.readbyqxmd.com/read/28918324/simultaneous-determination-and-pharmacokinetic-study-of-twelve-bioactive-compounds-in-rat-plasma-after-intravenous-administration-of-xuebijing-injection-by-uhplc-q-orbitrap-hrms
#14
Lihua Zuo, Qiuyue Zhong, Zhenhui Wang, Zhi Sun, Lin Zhou, Zhuolun Li, Tanye Xu, Yingying Shi, Jinfa Tang, Shuzhang Du, Xiaojian Zhang
Xuebijing injection (XBJ) is a traditional Chinese herbal prescription widely used in the treatment of sepsis. Extensive studies revealed that the major bioactive constituents of XBJ injection, including phenolic acids, flavonoids, monoterpene glycosides, lactones and organic acids, play an important role in the treatment. In this study, a rapid, sensitive and accurate ultra high performance liquid chromatography - Q Exactive hybrid quadrupole - orbitrap high-resolution accurate mass spectrometry (UHPLC-Q-Orbitrap HRMS) method was developed for simultaneous determination of twelve bioactive compounds in rat plasma after intravenous administration of XBJ injection...
September 8, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/28918323/quantitative-determination-of-carfilzomib-in-mouse-plasma-by-liquid-chromatography-tandem-mass-spectrometry-and-its-application-to-a-pharmacokinetic-study
#15
Jee Sun Min, Jiseon Kim, Jung Ho Kim, Doyun Kim, Yu Fen Zheng, Ji Eun Park, Wooin Lee, Soo Kyung Bae
A highly sensitive and rapid LC-MS/MS method was developed and validated to determine the levels of carfilzomib in mice plasma by using chlorpropamide as an internal standard. Carfilzomib and chlorpropamide were extracted from 5 μL of plasma after protein precipitation with acetonitrile. Chromatographic separation was performed on Phenomenex Luna C18 column (50×2.0mm id, 3μm). The mobile phase consisted of 0.1% formic acid in acetonitrile -0.1% formic acid in water (1:1v/v) and the flow rate was 0.3mL/min...
September 1, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/28917751/structural-characterization-of-electrochemically-and-in-vivo-generated-potential-metabolites-of-selected-cardiovascular-drugs-by-ec-uhplc-esi-ms-using-an-experimental-design-approach
#16
Małgorzata Szultka-Młyńska, Sylwia Bajkacz, Irena Baranowska, Bogusław Buszewski
In the last few years, a number of studies were conducted which aimed at understanding the mechanisms of cardiovascular drug, metabolism, and there is still the need to determine the metabolites of cardiac drugs for the purpose of metabolism control. In this study, we employ a direct combination of electrochemical oxidation and mass spectrometric (EC-MS) identification for monitoring the oxidation pathway of ten cardiovascular drugs (metoprolol, propranolol, propafenone, mexiletine, oxprenolol, pirbuterol, pindolol, cicloprolol, acebutolol and atenolol)...
January 1, 2018: Talanta
https://www.readbyqxmd.com/read/28917688/a-randomized-trial-of-pocket-echocardiography-integrated-mobile-health-device-assessments-in-modern-structural-heart-disease-clinics
#17
Sanjeev P Bhavnani, Srikanth Sola, David Adams, Ashwin Venkateshvaran, P K Dash, Partho P Sengupta
OBJECTIVES: This study sought to determine whether mobile health (mHealth) device assessments used as clinical decision support tools at the point-of-care can reduce the time to treatment and improve long-term outcomes among patients with rheumatic and structural heart diseases (SHD). BACKGROUND: Newly developed smartphone-connected mHealth devices represent promising methods to diagnose common diseases in resource-limited areas; however, the impact of technology-based care on long-term outcomes has not been rigorously evaluated...
September 9, 2017: JACC. Cardiovascular Imaging
https://www.readbyqxmd.com/read/28915825/effect-of-a-mobile-app-intervention-on-vegetable-consumption-in-overweight-adults-a-randomized-controlled-trial
#18
Sarah Mummah, Thomas N Robinson, Maya Mathur, Sarah Farzinkhou, Stephen Sutton, Christopher D Gardner
BACKGROUND: Mobile applications (apps) have been heralded as transformative tools to deliver behavioral health interventions at scale, but few have been tested in rigorous randomized controlled trials. We tested the effect of a mobile app to increase vegetable consumption among overweight adults attempting weight loss maintenance. METHODS: Overweight adults (n=135) aged 18-50 years with BMI=28-40 kg/m(2) near Stanford, CA were recruited from an ongoing 12-month weight loss trial (parent trial) and randomly assigned to either the stand-alone, theory-based Vegethon mobile app (enabling goal setting, self-monitoring, and feedback and using "process motivators" including fun, surprise, choice, control, social comparison, and competition) or a wait-listed control condition...
September 15, 2017: International Journal of Behavioral Nutrition and Physical Activity
https://www.readbyqxmd.com/read/28915532/formation-mechanism-of-human-serum-albumin-monolayers-on-positively-charged-polymer-microparticles
#19
Małgorzata Nattich-Rak, Marta Sadowska, Zbigniew Adamczyk, Michał Cieśla, Małgorzata Kąkol
Human serum albumin (HSA) adsorption on positively and negatively charged polystyrene microparticles was studied at various pHs and NaCl concentrations. Thorough electrophoretic mobility measurements were carried out that enabled to monitor in situ the progress of protein adsorption. The maximum coverage of irreversibly adsorbed HSA on microparticles was determined by different concentration depletion methods, one of them involving AFM imaging of residual molecules. An anomalous adsorption of HSA on the positive microparticles was observed at pH 3...
August 31, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28915422/determination-of-hydroxyurea-in-human-plasma-by-hplc-uv-using-derivatization-with-xanthydrol
#20
Tiphaine Legrand, Marie-Georgine Rakotoson, Frédéric Galactéros, Pablo Bartolucci, Anne Hulin
A simple and rapid high performance liquid chromatography (HPLC) method using ultraviolet (UV) detection was developed to determine hydroxyurea (HU) concentration in plasma sample after derivatization with xanthydrol. Two hundred microliters samples were spiked with methylurea (MeU) as internal standard and proteins were precipitated by adding methanol. Derivatization of HU and MeU was immediately performed by adding 0.02M xanthydrol and 1.5M HCl in order to obtain xanthyl-derivatives of HU and MeU that can be further separated using HPLC and quantified using UV detection at 240nm...
September 7, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
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