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https://www.readbyqxmd.com/read/29341881/clinical-implications-of-technological-advances-in-screening-for-atrial-fibrillation
#1
REVIEW
Nikhil Singh, Sung Chun, David Hadley, Victor Froelicher
The incidence of atrial fibrillation (AF) continues to increase worldwide as people live longer. AF is the leading cause of stroke among patients older than 75 years and is responsible for at least 15% of all strokes. Industry has responded to this problem with a plethora of monitoring devices. These include single lead ECG adhesive sensors, implantable loop recorders, smartphone attachments and wearables. This review will concentrate on clinical studies using these technologies. There are wearables including watches and watch-like devices that will be mentioned but these have not been validated for clinical use...
January 13, 2018: Progress in Cardiovascular Diseases
https://www.readbyqxmd.com/read/29340807/long-term-outcome-of-infliximab-optimization-for-overcoming-immunogenicity-in-patients-with-inflammatory-bowel-disease
#2
Konstantinos Papamichael, Ravy K Vajravelu, Mark T Osterman, Adam S Cheifetz
BACKGROUND: Preliminary data suggest that treatment optimization can reverse immunogenicity and regain response in patients with IBD and secondary loss of response (SLR) to anti-TNF therapy due to antidrug antibodies. However, data regarding the long-term outcome of these patients are scarce. AIMS: We aimed to investigate drug retention in IBD patients of whom infliximab was optimized to overcome immunogenicity and variables associated with drug retention. METHODS: This was a retrospective, multicenter study of consecutive IBD patients with antibodies to infliximab (ATI), based on either proactive or reactive therapeutic drug monitoring, who underwent infliximab optimization (increasing dose, shortening interval, adding an immunomodulator, or combination) to overcome immunogenicity from September 2012 to July 2015; they were followed through December 2015...
January 16, 2018: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/29339347/hospital-owned-apps-in-taiwan-nationwide-survey
#3
Hao-Yen Liu, Wui-Chiang Lee, Ying-Chou Sun, Jun-Jeng Fen, Tzeng-Ji Chen, Li-Fang Chou, Shinn-Jang Hwang
BACKGROUND: Over the last decade, the use of mobile phone apps in the health care industry has grown rapidly. Owing to the high penetration rate of Internet use in Taiwan, hospitals are eager to provide their own apps to improve the accessibility of medical care for patients. OBJECTIVE: The aims of this study were to provide an overview of the currently available hospital-owned apps in Taiwan and to conduct a cross-hospital comparison of app features. METHODS: In May 2017, the availability of apps from all 414 hospitals in Taiwan was surveyed from the hospital home pages and the Google Play app store...
January 16, 2018: JMIR MHealth and UHealth
https://www.readbyqxmd.com/read/29339296/silent-transmission-of-an-is1294b-deactivated-mcr-1-gene-with-inducible-colistin-resistance
#4
Kai Zhou, Qixia Luo, Qin Wang, Chen Huang, Haifeng Lu, Rossen W A John, Yonghong Xiao, Lanjuan Li
The global dissemination of the mobile colistin resistance mcr-1 is of special concern, as colistin is one of the last-resort antibiotics for the treatment of severe infections caused by carbapenem-resistant Gram-negative bacteria. Here, we characterized an inactive form of mcr-1 in a fluoroquinolone-resistant and colistin-susceptible uropathogenic Escherichia coli isolate (ECO3347). The mcr-1 gene was deactivated by the insertion of a 1.7-Kb IS1294b element flanked by two tetramers (GTTC), and located on a 62-Kb pHNSHP45-like plasmid (p3347-mcr-1)...
January 12, 2018: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/29339263/impact-of-organic-amendments-biochar-compost-and-peat-on-cd-and-zn-mobility-and-solubility-in-contaminated-soil-of-the-campine-region-after-three-years
#5
C E Egene, R Van Poucke, Y S Ok, E Meers, F M G Tack
To determine the long-term impact of organic amendments on metal (Cd and Zn) immobilization, soil from the Campine region was amended with holm oak-derived biochar, compost, and peat, and monitored over a 3-year period. Pot experiments were conducted by mixing the amendments independently at 2% and 4% (g/g) with the soil. The mobility and solubility of metals in the treatments were assessed by means of rhizon soil moisture samplers, sequential BCR extractions, and diffusive gradient in thin films (DGT). Over the three-year period, the 2% biochar addition resulted in an average decrease in pore water concentration of 40% for Cd and 48% for Zn whereas the 4% addition led to an average decrease of 66% for Cd and 77% for Zn...
January 13, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29338959/a-new-window-into-psychosis-the-rise-digital-phenotyping-smartphone-assessment-and-mobile-monitoring
#6
John Torous, Matcheri Keshavan
This commentary piece discusses recent advances in the use of mobile technologies like smartphone and wearable sensors for schizophrenia research. By framing both the opportunities as well as challenges for the field, this piece aims to frame the both current and future research efforts.
January 12, 2018: Schizophrenia Research
https://www.readbyqxmd.com/read/29338691/morca-ubiquitous-access-to-life-science-web-services
#7
Sergio Diaz-Del-Pino, Oswaldo Trelles, Juan Falgueras
BACKGROUND: Technical advances in mobile devices such as smartphones and tablets have produced an extraordinary increase in their use around the world and have become part of our daily lives. The possibility of carrying these devices in a pocket, particularly mobile phones, has enabled ubiquitous access to Internet resources. Furthermore, in the life sciences world there has been a vast proliferation of data types and services that finish as Web Services. This suggests the need for research into mobile clients to deal with life sciences applications for effective usage and exploitation...
January 16, 2018: BMC Genomics
https://www.readbyqxmd.com/read/29338249/highly-sensitive-and-wearable-in2o3-nanoribbon-transistor-biosensors-with-integrated-on-chip-gate-for-glucose-monitoring-in-body-fluids
#8
Qingzhou Liu, Yihang Liu, Fanqi Wu, Xuan Cao, Zhen Li, Mervat Alharbi, Ahmad N Abbas, Moh R Amer, Chongwu Zhou
Nanoribbon- and nanowire-based field-effect transistor (FET) biosensors have stimulated a lot of interest. However, most FET biosensors were achieved by using bulky Ag/AgCl electrodes or metal wire gates, which have prevented the biosensors from becoming truly wearable. Here, we demonstrate highly sensitive and conformal In2O3 nanoribbon FET biosensors with a fully integrated on-chip gold side gate, which have been laminated onto various surfaces, such as artificial arms and watches, and have enabled glucose detection in various body fluids, such as sweat and saliva...
January 17, 2018: ACS Nano
https://www.readbyqxmd.com/read/29337892/improving-remote-health-monitoring-a-low-complexity-ecg-compression-approach
#9
Mohamed Elgendi, Abdulla Al-Ali, Amr Mohamed, Rabab Ward
Recent advances in mobile technology have created a shift towards using battery-driven devices in remote monitoring settings and smart homes. Clinicians are carrying out diagnostic and screening procedures based on the electrocardiogram (ECG) signals collected remotely for outpatients who need continuous monitoring. High-speed transmission and analysis of large recorded ECG signals are essential, especially with the increased use of battery-powered devices. Exploring low-power alternative compression methodologies that have high efficiency and that enable ECG signal collection, transmission, and analysis in a smart home or remote location is required...
January 16, 2018: Diagnostics
https://www.readbyqxmd.com/read/29336905/getting-a-good-night-sleep-the-importance-of-recognizing-and-treating-nocturnal-hypokinesia-in-parkinson-s-disease
#10
REVIEW
Roongroj Bhidayasiri, Claudia Trenkwalder
When Parkinson's disease (PD) patients are asked about the quality of their sleep, their answers are dominated by difficulties associated with impaired mobility in bed, medically referred to as nocturnal hypokinesia. Nocturnal hypokinesia is symptomatic from the mid-stage of the disease, affecting up to 70% of PD patients, and contributes to poor sleep quality, and increased carer burden. Here we explore four areas of nocturnal hypokinesia that are relevant to clinical practice, namely: manifestations and definition; clinical assessment and objective monitoring; etiologies and contributing factors; and evidence-based therapeutic approaches...
January 5, 2018: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/29336825/detecting-the-occurrence-of-indigenous-and-non-indigenous-megafauna-through-fishermen-knowledge-a-complementary-tool-to-coastal-and-port-surveys
#11
E Azzurro, L Bolognini, B Dragičević, D Drakulović, J Dulčić, E Fanelli, F Grati, J Kolitari, L Lipej, E Magaletti, O Marković, S Matić-Skoko, B Mavrič, N Milone, A Joksimović, J Tomanić, A Scarpato, P Tutman, D Vrdoljak, F Zappacosta
Marine bioinvasions and other rapid biodiversity changes require today integrating existing monitoring tools with other complementary detection strategies to provide a more efficient management. Here we explored the efficacy of fishermen observations and traditional port surveys to effectively track the occurrence of both indigenous and non-indigenous megafauna in the Adriatic Sea. This consisted mainly of mobile taxa such as fishes, crustaceans and molluscs. Port surveys using traps and nets within 10 major Adriatic harbours, were compared with the information obtained from 153 interviews with local fishermen...
January 11, 2018: Marine Pollution Bulletin
https://www.readbyqxmd.com/read/29336278/use-of-2015-beers-criteria-medications-by-older-medicare-beneficiaries
#12
Rajul Patel, Leona Zhu, Dilraj Sohal, Elena Lenkova, Nichole Koshki, Joseph Woelfel, Carly Ranson, Cynthia S Valle-Oseguera, Edward L Rogan
OBJECTIVE: To examine the prevalence of potentially inappropriate medications (PIMs) in community-dwelling Medicare beneficiaries based on the updated 2015 American Geriatrics Society Beers criteria. DESIGN: Cross-sectional study. SETTING: Thirteen mobile Medicare clinics were held throughout Northern and Central California during the fall of 2015. PATIENTS, PARTICIPANTS: Noninstitutionalized Medicare beneficiaries 65 years of age and older taking one or more medications...
January 1, 2018: Consultant Pharmacist: the Journal of the American Society of Consultant Pharmacists
https://www.readbyqxmd.com/read/29335236/tanzania-health-information-technology-t-hit-system-pilot-test-of-a-tablet-based-system-to-improve-prevention-of-mother-to-child-transmission-of-hiv
#13
Sheana Bull, Deborah Sk Thomas, Elias C Nyanza, Sospatro E Ngallaba
BACKGROUND: The prevention of mother-to-child transmission (PMTCT) of HIV requires innovative solutions. Although routine monitoring is effective in some areas, standardized and easy-to-scale solutions to identify and monitor pregnant women, test them for HIV, and treat them and their children is still lacking. Mobile health (mHealth) offers opportunities for surveillance and reporting in rural areas of low- and middle-income countries. OBJECTIVE: The aim of this study was to document the preliminary impacts of the Tanzania Health Information Technology (T-HIT) system mHealth intervention aimed at health workers for PMTCT care delivery and capacity building in a rural area of Tanzania...
January 15, 2018: JMIR MHealth and UHealth
https://www.readbyqxmd.com/read/29334273/the-barthel-index-and-the-cumulated-ambulation-score-are-superior-to-the-de-morton-mobility-index-for-the-early-assessment-of-outcome-in-patients-with-a-hip-fracture-admitted-to-an-acute-geriatric-ward
#14
Signe Hulsbæk, Rikke Faebo Larsen, Susanne Rosthøj, Morten Tange Kristensen
PURPOSE: To examine clinimetric properties of the de Morton Mobility Index (DEMMI) in patients with hip fracture in comparison with the modified Barthel Index (BI), Cumulated Ambulation Score (CAS), and 30-s Chair Stand Test (30-s CST). MATERIALS AND METHODS: Two hundred and twenty two patients with a hip fracture admitted to a geriatric ward following surgery were assessed on day 1 and at discharge (mean of 9 [SD 5.1] post-surgery days). RESULTS: Ninety eight percent and 89% of patients were not able to perform the 30-s CST at baseline and at discharge (large floor effect), respectively...
January 15, 2018: Disability and Rehabilitation
https://www.readbyqxmd.com/read/29334125/determination-of-isoorientin-levels-in-rat-plasma-after-oral-administration-of-vaccinum-bracteatum-thunb-methanol-extract-by-high-performance-liquid-chromatography-tandem-mass-spectrometry
#15
Min-Ji Kim, Seung-Hwan Kwon, Choon-Gon Jang, Han-Joo Maeng
A simple, sensitive and rapid liquid chromatography tandem mass spectrometry method (LC-MS/MS) was developed and validated for the determination of plasma isoorientin levels in rats. After simple protein precipitation using methanol, chromatographic analysis was performed using a Synergi 4μ polar-RP 80A column (150 mm × 2.0 mm, 4 μm) under isocratic conditions and a mobile phase consisting of 0.1% formic acid in water and methanol (80:20, v/v) at a flow rate of 0.2 mL/min. In positive electrospray ionization mode, the protonated precursor and product ion transitions of isoorientin (m/z 449...
January 15, 2018: Biomedical Chromatography: BMC
https://www.readbyqxmd.com/read/29333328/learning-tree-structured-detection-cascades-for-heterogeneous-networks-of-embedded-devices
#16
Hamid Dadkhahi, Benjamin M Marlin
In this paper, we present a new approach to learning cascaded classifiers for use in computing environments that involve networks of heterogeneous and resource-constrained, low-power embedded compute and sensing nodes. We present a generalization of the classical linear detection cascade to the case of tree-structured cascades where different branches of the tree execute on different physical compute nodes in the network. Different nodes have access to different features, as well as access to potentially different computation and energy resources...
August 2017: KDD: Proceedings
https://www.readbyqxmd.com/read/29333080/comparisons-of-traffic-related-ultrafine-particle-number-concentrations-measured-in-two-urban-areas-by-central-residential-and-mobile-monitoring
#17
Matthew C Simon, Neelakshi Hudda, Elena N Naumova, Jonathan I Levy, Doug Brugge, John L Durant
Traffic-related ultrafine particles (UFP; <100 nanometers diameter) are ubiquitous in urban air. While studies have shown that UFP are toxic, epidemiological evidence of health effects, which is needed to inform risk assessment at the population scale, is limited due to challenges of accurately estimating UFP exposures. Epidemiologic studies often use empirical models to estimate UFP exposures; however, the monitoring strategies upon which the models are based have varied between studies. Our study compares particle number concentrations (PNC; a proxy for UFP) measured by three different monitoring approaches (central-site, short-term residential-site, and mobile on-road monitoring) in two study areas in metropolitan Boston (MA, USA)...
November 2017: Atmospheric Environment
https://www.readbyqxmd.com/read/29331971/a-study-protocol-for-a-non-randomised-comparison-trial-evaluating-the-feasibility-and-effectiveness-of-a-mobile-cognitive-behavioural-programme-with-integrated-coaching-for-anxious-adults-in-primary-care
#18
Eva Szigethy, Francis Solano, Meredith Wallace, Dina L Perry, Lauren Morrell, Kathryn Scott, Megan Jones Bell, Megan Oser
INTRODUCTION: Generalised anxiety disorder (GAD) and subclinical GAD are highly prevalent in primary care. Unmanaged anxiety worsens quality of life in patients seen in primary care practices and leads to increased medical utilisation and costs. Programmes that teach patients cognitive-behavioural therapy (CBT) techniques have been shown to improve anxiety and to prevent the evolution of anxiety symptoms to disorders, but access and engagement have hampered integration of CBT into medical settings...
January 13, 2018: BMJ Open
https://www.readbyqxmd.com/read/29331795/development-and-validation-of-an-uhplc-ms-ms-approach-for-simultaneous-quantification-of-five-bioactive-saponins-in-rat-plasma-application-to-a-comparative-pharmacokinetic-study-of-aqueous-extracts-of-raw-and-salt-processed-achyranthes-bidentata
#19
Yi Tao, Yingshan Du, Weidong Li, Baochang Cai
A simple, accurate and sensitive ultra high-performance liquid chromatography-tandem mass spectrometry approach was established for the simultaneous determination of β-ecdysterone, 25S-inokosterone, ginsenoside Ro, chikusetsusaponin IV and chikusetsusaponin IVa in rat plasma after oral administration of raw and salt-processed Achyranthes bidentata extract. The saponins were completely separated on a Waters BEH C18 UHPLC column by using acetonitrile/0.1% formic acid-water as mobile phases. The mass analysis was performed in a triple quadrupole mass spectrometer using multiple reaction monitoring (MRM) with negative scan mode...
January 9, 2018: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/29331693/disease-management-apps-and-technical-assistance-systems-for-bipolar-disorder-investigating-the-patients%C3%A2-point-of-view
#20
Henning Daus, Natalia Kislicyn, Stephan Heuer, Matthias Backenstrass
BACKGROUND: Smartphone-based disease management has become increasingly interesting for research in the field of bipolar disorders. This article investigates the attitudes of persons affected by this disorder towards the appropriation of mobile apps or assistance systems for the management of their disease. METHODS: We conducted two separate studies. Study 1 was an online survey with 88 participants. In study 2 we consulted 15 participants during a semi-structured interview...
January 2, 2018: Journal of Affective Disorders
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