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https://www.readbyqxmd.com/read/29779084/disease-activity-patterns-recorded-using-a-mobile-monitoring-system-are-associated-with-clinical-outcomes-of-patients-with-crohn-s-disease
#1
Eun Soo Kim, Sung Kook Kim, Byung Ik Jang, Kyeong Ok Kim, Eun Young Kim, Yoo Jin Lee, Hyun Seok Lee, Sang Gyu Kwak
BACKGROUND: Usefulness of a mobile monitoring system for Crohn's disease (CD) has not been evaluated. We aimed to determine whether disease activity patterns depicted using a web-based symptom diary for CD could indicate disease clinical outcomes. METHODS: Patients with CD from tertiary hospitals were prospectively invited to record their symptoms using a smartphone at least once a week. Disease activity patterns for at least 2 months were statistically classified into good and poor groups based on two factors in two consecutive time frames; the degree of score variation (maximum-minimum) in each frame and the trend (upward, stationary, or downward) of patterns indicated by the difference in the mean activity scores between two time frames...
May 19, 2018: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/29778874/simultaneous-determination-of-dihydrotestosterone-and-its-metabolites-in-mouse-sera-by-lc-ms-ms-with-chemical-derivatization
#2
Shashank Gorityala, Shuming Yang, Monica M Montano, Yan Xu
Androgens play a vital role in prostate cancer development, and their elimination and blockade are essential in the disease management. DHT is the key ligand for androgen receptor (AR) in the prostate. It is locally synthesized from testosterone. In the prostate, DHT is predominantly metabolized to α-diol and β-diol. Recent studies indicate that impaired DHT catabolism is associated with prostate cancer, signifying the necessity of a sensitive quantitative method for the determination of DHT and its metabolites...
May 16, 2018: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/29777392/determining-representative-ranges-of-point-sensors-in-distributed-networks
#3
John K Horne, Dale A Jacques
Distributed networks of stationary instruments provide high temporal scope (i.e., range/resolution) observations but are spatially limited as a set of point measurements. Measurement similarity between points typically decays with distance, which is used to set interpolation distances. The importance of analyzing spatiotemporal data at equivalent spatial and temporal scales has been identified but no standard procedure is used to interpolate space using temporally-indexed observations. Using concurrent mobile and stationary active acoustic, fish density data from a tidal energy site in Puget Sound, WA, USA, six methods are compared to estimate the range at which stationary measurements can be spatially interpolated...
May 18, 2018: Environmental Monitoring and Assessment
https://www.readbyqxmd.com/read/29775810/a-validated-uplc-ms-ms-method-for-the-quantitation-of-an-unstable-peptide-monocyte-locomotion-inhibitory-factor-mlif-in-human-plasma-and-its-application-to-a-pharmacokinetic-study
#4
Xuemei Liu, Pei Hu, Yongsheng Wang, Xizhu Wang, Jinghua Huang, Jin Li, Cheng Li, Hongyun Wang, Ji Jiang
Monocyte locomotion inhibitory factor (MLIF, Met-Gln-Cys-Asn-Ser), a pentapeptide with anti-inflammatory activity, was developed for neural protection in acute ischemic stroke. Determination of MLIF in human plasma samples is of great importance for pharmacokinetic evaluation in clinical studies. A reliable and sensitive method based on ultra-performance liquid chromatography coupled with tandem mass spectrometry (UPLC-MS/MS) was established for the measurement of MLIF in human plasma. Instability of peptide in matrix was the primary challenge in method development, which was properly resolved by addition of acidification reagents like sulfuric acid...
April 10, 2018: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/29775773/trimeprazine-is-enantioselectively-degraded-by-an-activated-sludge-in-ready-biodegradability-test-conditions
#5
Laura Escuder-Gilabert, Yolanda Martín-Biosca, Mireia Perez-Baeza, Salvador Sagrado, María José Medina-Hernández
A great number of available pharmaceuticals are chiral compounds. Although they are usually manufactured as racemic mixtures, they can be enantioselectively biodegraded as a result of microbial processes. In this paper, a biodegradability assay in similar conditions to those recommended in OECD tests of enantiomers of trimeprazine (a phenothiazine employed as a racemate) is carried out. Experiments were performed in batch mode using a minimal salts medium inoculated with an activated sludge (collected from a Valencian Waste Water Treatment Plant, WWTP) and supplemented with the racemate...
May 9, 2018: Water Research
https://www.readbyqxmd.com/read/29775536/spatial-variability-of-sources-and-mixing-state-of-atmospheric-particles-in-a-metropolitan-area
#6
Qing Ye, Peishi Gu, Hugh Z Li, Ellis S Robinson, Eric M Lipsky, Christos Kaltsonoudis, Alex K Y Lee, Joshua Schulz Apte, Allen L Robinson, Ryan Christopher Sullivan, Albert A Presto, Neil M Donahue
Characterizing intra-city variations of atmospheric particulate matter has mostly relied on fixed-site monitoring and quantifying variability in terms of different bulk aerosol species. In this study, we performed ground-based mobile measurements using a single-particle mass spectrometer to study spatial patterns of source-specific particles and the evolution of particle mixing state in 21 areas in the metropolitan area of Pittsburgh, PA. We selected sampling areas based on traffic density and restaurant density with each area ranging from 0...
May 18, 2018: Environmental Science & Technology
https://www.readbyqxmd.com/read/29773529/development-of-a-just-in-time-adaptive-mhealth-intervention-for-insomnia-usability-study
#7
I Wayan Pulantara, Bambang Parmanto, Anne Germain
BACKGROUND: Healthy sleep is a fundamental component of physical and brain health. Insomnia, however, is a prevalent sleep disorder that compromises functioning, productivity, and health. Therefore, developing efficient treatment delivery methods for insomnia can have significant societal and personal health impacts. Cognitive behavioral therapy for insomnia (CBTI) is the recommended first-line treatment of insomnia but access is currently limited for patients, since treatment must occur in specialty sleep clinics, which suffer from an insufficient number of trained clinicians...
May 17, 2018: JMIR Human Factors
https://www.readbyqxmd.com/read/29772601/hollow-mesoporous-structured-molecularly-imprinted-polymer-as-adsorbent-in-pipette-tip-solid-phase-extraction-for-the-determination-of-antiretrovirals-from-plasma-of-hiv-infected-patients
#8
Nathália Soares Simões, Hanna Leijoto de Oliveira, Ricky Cássio Santos da Silva, Leila Suleimara Teixeira, Thaís Lorenna Souza Sales, Whocely Victor de Castro, Maria José Nunes de Paiva, Cristina Sanches, Keyller Bastos Borges
In this work a hollow mesoporous structured molecularly imprinted polymer was synthetized and used as adsorbent in pipette-tip solid-phase extraction for the determination of lamivudine (3TC), zidovudine (AZT) and efavirenz (EFZ) from plasma of human immunodeficiency virus (HIV) infected patients by high-performance liquid chromatography (HPLC). All parameters that influence the recovery of the pipette tip based on hollow mesoporous molecularly imprinted polymer solid-phase extraction (PT-HM-MIP-SPE) method were systematically studied and discussed in detail...
May 17, 2018: Electrophoresis
https://www.readbyqxmd.com/read/29772118/proms-for-pain-in-adult-cancer-patients-a-systematic-review-of-measurement-properties
#9
REVIEW
Asma A Abahussin, Robert M West, David C Wong, Lucy E Ziegler
CONTEXT: Pain is one of the most devastating symptoms for cancer patients. One-third of patients who experience pain do not receive effective treatment. A key barrier to effective pain management is lack of routine measurement and monitoring of pain. Patient-Reported Outcome Measures (PROMs) are recommended for measuring cancer pain. However, evidence to guide the selection of the most appropriate measure to identify and monitor cancer pain is limited. A systematic review of measurement properties of PROMs for pain in cancer patients is needed to identify the best validated measure for adoption to an electronic platform...
May 17, 2018: Pain Practice: the Official Journal of World Institute of Pain
https://www.readbyqxmd.com/read/29771620/self-reported-functional-mobility-balance-confidence-and-prosthetic-use-are-associated-with-daily-step-counts-among-individuals-with-a-unilateral-transtibial-amputation
#10
Jaclyn Megan Sions, Elisa Sarah Arch, John Robert Horne
BACKGROUND: Adults postamputation are not meeting physical activity recommendations. Physical activity is an important consideration in prosthetic prescription. The objective of this study was to determine if functional mobility, balance confidence, and prosthetic use are associated with physical activity among adults with a lower-limb amputation. METHODS: This study recruited patients aged 18-85 years with unilateral transtibial amputations. The Cumulative Illness Rating Scale was used to determine comorbidity burden...
June 1, 2018: Journal of Physical Activity & Health
https://www.readbyqxmd.com/read/29770651/-analysis-on-the-situation-of-schistosome-infections-in-floating-population-in-national-schistosomiasis-surveillance-sites-of-china
#11
Guan Zhou, Lü Shan, Li Shi-Zhu, Dang Hui, Zhang Li-Juan, Xu Jing
OBJECTIVE: To understand the situation of Schistosoma japonicum infections in foating population and its epidemiological characteristics in China, so as to provide insights into the development of the surveillance strategy and interventions for schistosomiasis. METHODS: According to the protocol of national surveillance project, indirect hemagglutination test (IHA) was employed for serological screening of S. japonicum infections among the floating population in the national schistosomiasis surveillance sites of China from 2005 to 2014, and the sero-positives were subjected to parasitological examinations...
April 20, 2018: Zhongguo Xue Xi Chong Bing Fang Zhi za Zhi, Chinese Journal of Schistosomiasis Control
https://www.readbyqxmd.com/read/29768657/simultaneous-quantification-of-fentanyl-sufentanil-cefazolin-doxapram-and-keto-doxapram-in-plasma-using-liquid-chromatography-tandem-mass-spectrometry
#12
Robert B Flint, Soma Bahmany, Bart C H van der Nagel, Birgit C P Koch
A simple and specific UPLC-MS/MS method was developed and validated for simultaneous quantification of fentanyl, sufentanil, cefazolin, doxapram and its active metabolite keto-doxapram. The internal standard was fentanyl-d5 for all analytes. Chromatographic separation was achieved with a reversed phase Acquity UPLC HSS T3 column with a run-time of only 5.0 minutes per injected sample. Gradient elution was performed with a mobile phase consisting of ammonium acetate, formic acid in Milli-Q ultrapure water or in methanol with a total flow rate of 0...
May 16, 2018: Biomedical Chromatography: BMC
https://www.readbyqxmd.com/read/29764425/mobility-patterns-and-associated-factors-among-pregnant-internal-migrant-women-in-china-a-cross-sectional-study-from-a-national-monitoring-survey
#13
Ying Ji, Xiaoping Zhao, Zhili Wang, Shenglan Liu, Yang Shen, Chun Chang
BACKGROUND: Residential instability during pregnancy has been linked to poor health outcomes. As a first step toward providing better health care to pregnant migrant women, the size and characteristics of this population and factors associated with mobility during pregnancy should be studied. METHODS: Using the "Monitoring Data of Chinese Migrants" for 2012, from the Chinese National Population and Family Planning Commission, this study explored mobility patterns during pregnancy and associated factors among migrants within China...
May 15, 2018: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/29763980/arterial-stiffness-in-people-with-type-2-diabetes-and-obstructive-sleep-apnoea
#14
M Hvelplund Kristiansen, A M Banghøj, E Laugesen, L Tarnow
AIMS: To examine whether people with Type 2 diabetes with concurrent obstructive sleep apnoea have increased arterial stiffness as compared with people with Type 2 diabetes without obstructive sleep apnoea. METHODS: In a study with a case-control design, 40 people with Type 2 diabetes and treatment-naïve moderate to severe obstructive sleep apnoea (Apnoea-Hypopnoea Index ≥15) and a control group of 31 people with Type 2 diabetes without obstructive sleep apnoea (Apnoea-Hypopnoea Index <5) were examined...
May 15, 2018: Diabetic Medicine: a Journal of the British Diabetic Association
https://www.readbyqxmd.com/read/29762651/development-of-an-lc-ms-method-for-4-fluoroaniline-determination-in-ezetimibe
#15
Shubo Dong, Hanyue Yang, Deju Ye
A rapid and sensitive high-performance liquid chromatography-mass spectrometry method was developed and validated to determine 4-fluoroaniline concentration in ezetimibe. Chromatographic separation was achieved on a Phenomenex Gemini-NX C18 column (150 × 4.6 mm, 3 μm) maintained at 30°C. The liquid chromatography system was operated in gradient mode with an injection volume of 20 μL at a flow rate of 1 mL/min. Mobile phase A was water and mobile phase B consisted of acetonitrile with 0.05% acetic acid. The detection was performed using a single quadrupole mass spectrometer in single ion monitoring mode by using positive ionization...
May 14, 2018: Journal of Chromatographic Science
https://www.readbyqxmd.com/read/29762555/global-transcriptome-analysis-identifies-weight-regain-induced-activation-of-adaptive-immune-responses-in-white-adipose-tissue-of-mice
#16
D S Kyung, H R Sung, Y J Kim, K D Kim, S Y Cho, J H Choi, Y-H Lee, I Y Kim, J K Seong
OBJECTIVE: Studies have indicated that weight regain following weight loss predisposes obese individuals to metabolic disorders; however, the molecular mechanism of this potential adverse effect of weight regain is not fully understood. Here we investigated global transcriptome changes and the immune response in mouse white adipose tissue caused by weight regain. DESIGN: We established a diet switch protocol to compare the effects of weight regain with those of weight gain without precedent weight loss, weight loss maintenance and chow diet...
December 7, 2017: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/29762493/a-crowdsensing-based-analytical-framework-for-perceptional-degradation-of-ott-web-browsing
#17
Ke Li, Hai Wang, Xiaolong Xu, Yu Du, Yuansheng Liu, M Omair Ahmad
Service perception analysis is crucial for understanding both user experiences and network quality as well as for maintaining and optimizing of mobile networks. Given the rapid development of mobile Internet and over-the-top (OTT) services, the conventional network-centric mode of network operation and maintenance is no longer effective. Therefore, developing an approach to evaluate and optimizing users' service perceptions has become increasingly important. Meanwhile, the development of a new sensing paradigm, mobile crowdsensing (MCS), makes it possible to evaluate and analyze the user's OTT service perception from end-user's point of view other than from the network side...
May 15, 2018: Sensors
https://www.readbyqxmd.com/read/29762018/combining-measurements-from-mobile-monitoring-and-a-reference-site-to-develop-models-of-ambient-ultrafine-particle-number-concentration-at-residences
#18
Matthew C Simon, Allison P Patton, Elena N Naumova, Jonathan I Levy, Prashant Kumar, Doug Brugge, John L Durant
Significant spatial and temporal variation in ultrafine particle (UFP; <100 nanometers in diameter) concentrations creates challenges in developing predictive models for epidemiological investigations. We compared the performance of land-use regression models built by combining mobile and stationary measurements (hybrid model) with a regression model built using mobile measurements only (mobile model) in Chelsea and Boston, MA (USA). In each study area, particle number concentration (PNC; a proxy for UFP) was measured at a stationary reference site and with a mobile laboratory driven along a fixed route during a ~1-year monitoring period...
May 15, 2018: Environmental Science & Technology
https://www.readbyqxmd.com/read/29760879/smell-the-change-on-the-potential-of-gas-chromatographic-ion-mobility-spectrometry-in-ecosystem-monitoring
#19
Wolfgang Vautz, Chandrasekhara Hariharan, Maximilian Weigend
Plant volatile organic compounds (pVOCs) are being recognized as an important factor in plant-environment interactions. Both the type and amount of the emissions appear to be heavily affected by climate change. A range of studies therefore has been directed toward understanding pVOC emissions, mostly under laboratory conditions (branch/leaf enclosure). However, there is a lack of rapid, sensitive, and selective analytical methods, and therefore, only little is known about VOC emissions under natural, outdoor conditions...
May 2018: Ecology and Evolution
https://www.readbyqxmd.com/read/29759957/a-mobile-health-intervention-to-reduce-pain-and-improve-health-morph-in-older-adults-with-obesity-protocol-for-the-morph-trial
#20
Jason Fanning, Amber K Brooks, Edward Ip, Barbara J Nicklas, W Jack Rejeski
BACKGROUND: Chronic pain is a complex, age-related health issue that affects both physical functioning and quality of life. Because the impact of chronic pain is worsened by obesity and inactivity, nonpharmacological interventions that promote movement, reduce sitting, and aid in weight loss are needed to help manage pain symptoms among older adults with chronic pain. OBJECTIVE: The Mobile Intervention to Reduce Pain and Improve Health (MORPH) pilot trial aims to develop and test the feasibility and acceptability of a novel, patient-centered intervention to reduce chronic pain and improve physical functioning in older adults, leveraging the combination of telecoaching and individually adaptive mHealth tools to decrease both body mass and sedentary behavior...
May 14, 2018: JMIR Research Protocols
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