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https://www.readbyqxmd.com/read/28441352/high-throughput-determination-of-sodium-danshensu-in-beagle-dogs-by-the-lcms-ms-method-employing-liquid-liquid-extraction-based-on-96-well-format-plates
#1
Jingjing Jiang, Xin Zhao, Xiuxiu Li, Shengyuan Wu, Shidan Yu, Yuefen Lou, Guorong Fan
Sodium Danshensu (sodium d-(+)-β-(3,4-dihydroxyphenyl) lactate), one of the water-soluble ingredients in Salvia miltiorrhiza, exhibits potent relaxation of the coronary artery and anticoagulation effection. A high-throughput, rapid, and sensitive method combining liquid chromatography with electrospray ionization tandem mass spectrometry to determine the sodium danshensu in beagle dog plasma was developed and validated, using gallic acid as an internal standard (IS). Acidified plasma samples were extracted using 96-well liquid-liquid extraction, and were eluted on a CNW Athena C18 column (3 μm, 2...
April 25, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28438425/mobile-laboratories-an-innovative-and-efficient-solution-for-radiological-characterization-of-sites-under-or-after-decommissioning
#2
V Goudeau, B Daniel, D Dubot
During the operation and the decommissioning of a nuclear site the operator must assure the protection of the workers and the environment. It must furthermore identify and classify the various wastes, while optimizing the associated costs. At all stages of the decommissioning radiological measurements are performed to determine the initial situation, to monitor the demolition and clean-up, and to verify the final situation. Radiochemical analysis is crucial for the radiological evaluation process to optimize the clean-up operations and to the respect limits defined with the authorities...
April 21, 2017: Journal of Environmental Radioactivity
https://www.readbyqxmd.com/read/28437720/determination-of-a-novel-anticancer-ampk-activator-hernandezine-in-rat-plasma-and-tissues-with-a-validated-uhplc-ms-ms-method-application-to-pharmacokinetics-and-tissue-distribution-study
#3
Yang Song, Zhibin Wang, Baozhen Zhang, Yujia Zhang, Weipeng Zhang, Chunjuan Yang, Fanhao Meng, Xuesong Feng
Hernandezine, a novel anticancer AMPK activator, is a major active constituent of Thalictrum Ranunculaceae. A simple, specific and sensitive liquid chromatography tandem mass spectrometry (LC-MS/MS) method has been developed and validated for the quantification of hernandezine in rat plasma and tissues after intravenous administration. Sample preparation was carried out through a protein-precipitation extraction with acetonitrile using tetrandrine as internal standard (IS). The chromatographic separation was achieved by using an Agilent ZORBAX Eclipse Plus C18 column with a mobile phase of acetonitrile and water (containing 10mM ammonium acetate) in an isocratic elution way...
April 8, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/28436907/reliability-of-lagged-poincar%C3%A3-plot-parameters-in-ultra-short-heart-rate-variability-series-application-on-affective-sounds
#4
Mimma Nardelli, Alberto Greco, Juan Bolea, Gaetano Valenza, Enzo Pasquale Scilingo, Raquel Bailon
The number of studies about ultra-short cardiovascular time series is increasing because of the demand for mobile applications in telemedicine and e-health monitoring. However, the current literature still needs a proper validation of heartbeat nonlinear dynamics assessment from ultra-short time series. This paper reports on the reliability of the Lagged Poincaré Plot (LPP) parameters - calculated from ultra-short cardiovascular time series. Reliability is studied on simulated as well as on real RR series...
April 18, 2017: IEEE Journal of Biomedical and Health Informatics
https://www.readbyqxmd.com/read/28436842/a-hybrid-image-registration-and-matching-framework-for-real-time-motion-tracking-in-mri-guided-radiotherapy
#5
Matteo Seregni, Chiara Paganelli, Paul Summers, Massimo Bellomi, Guido Baroni, Marco Riboldi
OBJECTIVE: MRI-guided radiotherapy (MRIgRT) is an emerging treatment technique where anatomical and pathological structures are imaged through integrated MR-radiotherapy units. This work aims (i) at assessing the accuracy of optical-flow based motion tracking in liver cine-MRI sequences and (ii) at testing a MRIgRT workflow combining similarity-based image matching with image registration. METHODS: After an initialization stage, a set of template images is collected and registered to the first frame of the cine-MRI sequence...
April 24, 2017: IEEE Transactions on Bio-medical Engineering
https://www.readbyqxmd.com/read/28436118/enantioselective-potential-of-polysaccharide-based-chiral-stationary-phases-in-supercritical-fluid-chromatography
#6
Gabriela Kucerova, Kveta Kalikova, Eva Tesarova
The enantioselective potential of two polysaccharide-based chiral stationary phases for analysis of chiral structurally diverse biologically active compounds was evaluated in supercritical fluid chromatography using a set of 52 analytes. The chiral selectors immobilized on 2.5 μm silica particles were tris-(3,5-dimethylphenylcarmabate) derivatives of cellulose or amylose. The influence of the polysaccharide backbone, different organic modifiers, and different mobile phase additives on retention and enantioseparation was monitored...
April 24, 2017: Chirality
https://www.readbyqxmd.com/read/28433042/-alarmins-and-surgical-injury
#7
J Máca, M Peteja
Surgical intervention is an inseparable part of the management of serious surgical disease. However, surgery also presents a potential risk related to the so-called surgical injury causing immune response. When dysregulated the immune activation is able to cause local complications (i.e. wound dehiscence, impaired healing). Systemic decompartmentization of the immunologic disturbance can negatively influence long-term outcomes (i.e. hospital length of stay, mortality). Due to aseptic conditions in the operating room, such an immune activation is almost always of sterile nature...
2017: Rozhledy V Chirurgii: Měsíčník Československé Chirurgické Společnosti
https://www.readbyqxmd.com/read/28432532/a-portable-battery-powered-microfluidic-impedance-cytometer-with-smartphone-readout-towards-personal-health-monitoring
#8
Niloy Talukder, Abbas Furniturewalla, Tuan Le, Matthew Chan, Shreyas Hirday, Xinnan Cao, Pengfei Xie, Zhongtian Lin, Azam Gholizadeh, Steve Orbine, Mehdi Javanmard
We present a portable system for personalized blood cell counting consisting of a microfluidic impedance cytometer and portable analog readout electronics, feeding into an analog-to-digital converter (ADC), and being transmitted via Bluetooth to a user-accessible mobile application. We fabricated a microfluidic impedance cytometer with a novel portable analog readout. The novel design of the analog readout, which consists of a lock-in-amplifier followed by a high-pass filter stage for subtraction of drift and DC offset, and a post-subtraction high gain stage, enables detection of particles and cells as small as 1 μm in diameter, despite using a low-end 8-bit ADC...
June 2017: Biomedical Microdevices
https://www.readbyqxmd.com/read/28428734/defining-a-staged-based-process-for-economic-and-financial-evaluations-of-mhealth-programs
#9
Amnesty E LeFevre, Samuel D Shillcutt, Sean Broomhead, Alain B Labrique, Tom Jones
Mobile and wireless technology for health (mHealth) has the potential to improve health outcomes by addressing critical health systems constraints that impede coverage, utilization, and effectiveness of health services. To date, few mHealth programs have been implemented at scale and there remains a paucity of evidence on their effectiveness and value for money. This paper aims to improve understanding among mHealth program managers and key stakeholders of how to select methods for economic evaluation (comparative analysis for determining value for money) and financial evaluation (determination of the cost of implementing an intervention, estimation of costs for sustaining or expanding an intervention, and assessment of its affordability)...
2017: Cost Effectiveness and Resource Allocation: C/E
https://www.readbyqxmd.com/read/28428642/-technology-and-prevention-in-the-era-of-mobile-health-applications-for-cancer-screening-programs
#10
Fabrizio Bert, Maria Rosaria Gualano, Salvatore Clemente, Giulia Villa, Roberta Siliquini
The Italian national health system provides screening to detect breast, colorecatal and cervical cancers, however, population adherence is not as high as expected. Smartphones and their applications (apps) could be used as a tool to communicate with the population and to help improve adherence. The aim of this study was to analyze the features and functions of smartphone applications aimed at secondary prevention of oncological diseases. In February 2016, we reviewed online app stores, using specific key-words, to search for available apps for cancer screening...
January 2017: Igiene e Sanità Pubblica
https://www.readbyqxmd.com/read/28428158/mobile-application-to-promote-adherence-to-oral-chemotherapy-and-symptom-management-a-protocol-for-design-and-development
#11
Joel Nathan Fishbein, Lauren Ellen Nisotel, James John MacDonald, Nicole Amoyal Pensak, Jamie Michele Jacobs, Clare Flanagan, Kamal Jethwani, Joseph Andrew Greer
BACKGROUND: Oral chemotherapy is increasingly used in place of traditional intravenous chemotherapy to treat patients with cancer. While oral chemotherapy includes benefits such as ease of administration, convenience, and minimization of invasive infusions, patients receive less oversight, support, and symptom monitoring from clinicians. Additionally, adherence is a well-documented challenge for patients with cancer prescribed oral chemotherapy regimens. With the ever-growing presence of smartphones and potential for efficacious behavioral intervention technology, we created a mobile health intervention for medication and symptom management...
April 20, 2017: JMIR Research Protocols
https://www.readbyqxmd.com/read/28426512/technology-in-s-c-assessing-bodyweight-squat-technique-with-wearable-sensors
#12
Martin A O'Reilly, Darragh F Whelan, Tomas E Ward, Eamonn Delahunt, Brian M Caulfield
Strength and conditioning (S&C) coaches offer expert guidance to help those they work with achieve their personal fitness goals. However it is not always practical to operate under the direct supervision of an S&C coach and consequently individuals are often left training without expert oversight. Recent developments in inertial measurement units (IMUs) and mobile computing platforms have allowed for the possibility of unobtrusive motion tracking systems and the provision of real-time individualised feedback regarding exercise performance...
April 15, 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/28426231/the-prevalence-of-integrons-as-the-carrier-of-antibiotic-resistance-genes-in-natural-and-man-made-environments
#13
Liping Ma, An-Dong Li, Xiao-Le Yin, Tong Zhang
Class 1 integrase intI1 has been considered as a good proxy for anthropogenic pollution because of being linked to genes conferring resistance to antibiotics. The gene cassettes of class 1 integrons could carry diverse antibiotic resistance genes (ARGs) and conduct horizontal gene transfer among microorganisms. The present study applied high-throughput sequencing technique combined with an intI1 database and genome assembly to quantify the abundance of intI1 in 64 environmental samples from 8 ecosystems, and to investigate the diverse arrangements of ARG-carrying gene cassettes (ACGCs) carried by class 1 integrons...
April 20, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28423812/designing-an-e-learning-platform-for-postoperative-arthroplasty-adverse-events
#14
Ole Andreas Krumsvik, Ankica Babic
This paper presents a mobile software application development for e-learning based on the adverse events data within the field of arthroplasty. The application aims at providing a learning platform for physicians, patients, and medical students. Design of user interface aims to meet requirements of several user groups concerned with the adverse events of the knee and hip implants. Besides the clinical patient data, the platform wants to include even electronic patient data as a result of self-monitoring. Two different modules were created, one for medical staff and one for patients, both divided into the knee and hip areas...
2017: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/28423753/severity-summarization-and-just-in-time-alert-computation-in-mhealth-monitoring
#15
Rahul Krishnan Pathinarupothi, Bithin Alangot, Ekanath Rangan
Mobile health is fast evolving into a practical solution to remotely monitor high-risk patients and deliver timely intervention in case of emergencies. Building upon our previous work on a fast and power efficient summarization framework for remote health monitoring applications, called RASPRO (Rapid Alerts Summarization for Effective Prognosis), we have developed a real-time criticality detection technique, which ensures meeting physician defined interventional time. We also present the results from initial testing of this technique...
2017: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/28423744/design-and-validation-of-a-platform-to-evaluate-mhealth-apps
#16
Daniel Philpott, Aziz Guergachi, Karim Keshavjee
Emerging technologies show great potential in the field of patient care. One such technology is mobile heath applications (mhealth apps), which have exploded in number and variety in recent years, and offer great promise in the ability to collect and monitor patient health data. Despite their apparent success in proliferation and user adoption, these applications struggle to integrate into the primary care system and there is scant information regarding their efficacy to effect patient behavior and consequently health outcomes...
2017: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/28423459/breaks-in-modis-time-series-portend-vegetation-change-verification-using-long-term-data-in-an-arid-grassland-ecosystem
#17
Dawn M Browning, Jonathan J Maynard, Jason W Karl, Debra C Peters
Frequency and severity of extreme climatic events are forecast to increase in the 21st century. Predicting how managed ecosystems may respond to climatic extremes is intensified by uncertainty associated with knowing when, where, and how long effects of extreme events will be manifest in an ecosystem. In water-limited ecosystems with high inter-annual variability in rainfall, it is important to be able to distinguish responses that result from seasonal fluctuations in rainfall from long-term directional increases or decreases in precipitation...
April 19, 2017: Ecological Applications: a Publication of the Ecological Society of America
https://www.readbyqxmd.com/read/28421409/six-minute-walk-test-for-assessing-physical-functional-capacity-in-chronic-heart-failure
#18
REVIEW
Huiyun Du, Parichat Wonggom, Jintana Tongpeth, Robyn A Clark
PURPOSE OF THE REVIEW: The six-minute walk test (6MWT) is a submaximal exercise test for evaluating physical functional capacity. This review aims to report the research on the use of the 6MWT in chronic heart failure (CHF) that has been published in the past 5 years. RECENT FINDINGS: The 6MWT distance does not accurately reflect peak VO2. Minimal clinically important difference in the 6MWT distance, and additional measurements, such as heart rate recovery, can assist in the interpretation of the 6MWT distance, so management decisions can be made...
April 18, 2017: Current Heart Failure Reports
https://www.readbyqxmd.com/read/28421308/an-intelligent-remote-monitoring-system-for-total-knee-arthroplasty-patients
#19
Yunus Msayib, Patrick Gaydecki, Michael Callaghan, Nicola Dale, Sheheera Ismail
For the first six weeks following total knee arthroplasty (TKA), a patient will attend an outpatient clinic typically seen twice weekly. Here, an exercise regime is performed and improvement assessed using a hand held goniometer that measures the maximum angle of knee flexion, an important metric of progress. Additionally a series of daily exercises is performed at home, recorded in a diary. This protocol has problems. Patients must attend the hospital with assistance since they are not permitted to drive for six weeks following the procedure; appointments are sometimes missed; there are occasionally not enough physiotherapy appointment available; furthermore, it is difficult to be sure that patients are compliant with their exercises at home...
June 2017: Journal of Medical Systems
https://www.readbyqxmd.com/read/28420605/scalable-passive-sleep-monitoring-using-mobile-phones-opportunities-and-obstacles
#20
Sohrab Saeb, Thaddeus R Cybulski, Konrad P Kording, David C Mohr
BACKGROUND: Sleep is a critical aspect of people's well-being and as such assessing sleep is an important indicator of a person's health. Traditional methods of sleep assessment are either time- and resource-intensive or suffer from self-reporting biases. Recently, researchers have started to use mobile phones to passively assess sleep in individuals' daily lives. However, this work remains in its early stages, having only examined relatively small and homogeneous populations in carefully controlled contexts...
April 18, 2017: Journal of Medical Internet Research
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