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https://www.readbyqxmd.com/read/29149735/carbamazepine-lamotrigine-levetiracetam-and-valproic-acid-in-dried-blood-spots-with-liquid-chromatography-tandem-mass-spectrometry-method-development-and-validation
#1
Camilla Linder, Anna Hansson, Sara Sadek, Lars L Gustafsson, Anton Pohanka
Monitoring of antiepileptic drugs in children with epilepsy require multiple visits at a clinic for blood collection. Dried blood spot sampling is an alternative way of collection, performed at home by self-collection and can save time and costs for patients and family members. The aim was to develop and validate an LC-MS/MS dried blood spot method for carbamazepine, lamotrigine, levetiracetam and valproic acid with the requirements of using standard equipment and material in a routine laboratory setting. Whatman-903 filter paper was utilized, and discs were punched into a 96 well plate with an automated puncher and barcode reading...
November 4, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/29149175/the-introduction-of-dengue-follows-transportation-infrastructure-changes-in-the-state-of-acre-brazil-a-network-based-analysis
#2
Raquel Martins Lana, Marcelo Ferreira da Costa Gomes, Tiago França Melo de Lima, Nildimar Alves Honório, Cláudia Torres Codeço
Human mobility, presence and passive transportation of Aedes aegypti mosquito, and environmental characteristics are a group of factors which contribute to the success of dengue spread and establishment. To understand this process, we assess data from dengue national and municipal basins regarding population and demographics, transportation network, human mobility, and Ae. aegypti monitoring for the Brazilian state of Acre since the first recorded dengue case in the year 2000 to the year 2015. During this period, several changes in Acre's transport infrastructure and urbanization have been started...
November 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29148582/comparative-pharmacokinetics-study-of-orientin-in-rat-plasma-by-uhplc-ms-ms-after-intravenous-administration-of-single-orientin-and-trollius-chinensis-bunge-extract
#3
Nan Zhao, Qi Sun, Yang Song, Lin Wang, Tingjian Zhang, Fanhao Meng
Orientin showed a broad array of biological activities, and it is the major bioactive compound in the Trollius chinensis Bunge. Thus, this paper was conducted to investigate the comparative pharmacokinetics of orientin after intravenous administration of single orientin and Trollius chinensis Bunge extract. Sample preparation involved a simple one-step deproteinization procedure with acetonitrile. Chromatographic separation was achieved on a Waters BEH C18 column with a mobile phase consisting of acetonitrile and water containing 0...
November 17, 2017: Biomedical Chromatography: BMC
https://www.readbyqxmd.com/read/29148314/clinical-decision-support-systems-in-hospital-care-using-ubiquitous-devices-current-issues-and-challenges
#4
Mirza Mansoor Baig, Hamid GholamHosseini, Aasia A Moqeem, Farhaan Mirza, Maria Lindén
Supporting clinicians in decision making using advanced technologies has been an active research area in biomedical engineering during the past years. Among a wide range of ubiquitous systems, smartphone applications have been increasingly developed in healthcare settings to help clinicians as well as patients. Today, many smartphone applications, from basic data analysis to advanced patient monitoring, are available to clinicians and patients. Such applications are now increasingly integrating into healthcare for clinical decision support, and therefore, concerns around accuracy, stability, and dependency of these applications are rising...
November 1, 2017: Health Informatics Journal
https://www.readbyqxmd.com/read/29148112/big-data-and-data-science-in-healthcare-what-nurses-and-midwives-need-to-know
#5
EDITORIAL
Siobhan O'Connor
The evolution of technology in contemporary society has been accelerating in recent decades, with smaller, more interconnected hardware devices and software applications becoming the norm. As desktop computing paved the way for mobile platforms, which are now transitioning to wearable devices and other sensors, it is inevitable these electronic tools will advance into the realm of nanotechnology and biotechnology in the years to come. As the proliferation of information and communication technology continues it has led to a tsunami of digital data (Bates et al, 2014), which is being collected on many aspects of life...
November 17, 2017: Journal of Clinical Nursing
https://www.readbyqxmd.com/read/29144207/exploring-physical-activity-behaviour-needs-for-and-interest-in-a-technology-delivered-home-based-exercise-programme-among-patients-with-intermittent-claudication
#6
Nils Cornelis, Roselien Buys, Inge Fourneau, Tijl Dewit, Véronique Cornelissen
BACKGROUND: Supervised walking is a first line therapy in peripheral arterial disease (PAD) with complaints of intermittent claudication. However, uptake of supervised programmes is low. Home-based exercise seems an appealing alternative; especially since technological advances, such as tele-coaching and tele-monitoring, may facilitate the process and support patients when adopting a physically active lifestyle. To guide the development of such an intervention, it is important to identify barriers of physical activity and the needs and interests for technology-enabled exercise in this patient group...
November 16, 2017: VASA. Zeitschrift Für Gefässkrankheiten
https://www.readbyqxmd.com/read/29143972/determination-of-tubuloside-b-by-lc-ms-ms-and-its-application-to-a-pharmacokinetic-study-in-rats
#7
Shenbao Yang, Ruiying Qu, Peilu Sun, Shan Xiong, Siyi Yan, Zhipeng Deng
Tubuloside B, a novel neuroprotective phenylethanoid, is a major active constituent of Cistanche tubulosa and Cistanche deserticola. A specific and sensitive liquid chromatography tandem mass spectrometry (LC-MS/MS) method has been developed and validated for the quantification of tubuloside B in rat plasma. Sample preparation was conducted through a protein-precipitation extraction with methanol using tubuloside A as internal standard (IS). Chromatographic separation was achieved by using a Capcell Pak C18 column (2...
November 16, 2017: Biomedical Chromatography: BMC
https://www.readbyqxmd.com/read/29142283/a-mobile-device-based-imaging-spectrometer-for-environmental-monitoring-by-attaching-a-lightweight-small-module-to-a-commercial-digital-camera
#8
Fuhong Cai, Wen Lu, Wuxiong Shi, Sailing He
Spatially-explicit data are essential for remote sensing of ecological phenomena. Lately, recent innovations in mobile device platforms have led to an upsurge in on-site rapid detection. For instance, CMOS chips in smart phones and digital cameras serve as excellent sensors for scientific research. In this paper, a mobile device-based imaging spectrometer module (weighing about 99 g) is developed and equipped on a Single Lens Reflex camera. Utilizing this lightweight module, as well as commonly used photographic equipment, we demonstrate its utility through a series of on-site multispectral imaging, including ocean (or lake) water-color sensing and plant reflectance measurement...
November 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29142011/effect-of-distinct-lifestyle-interventions-on-mobilization-of-fat-storage-pools-the-central-mri-randomized-controlled-trial
#9
Yftach Gepner, Ilan Shelef, Dan Schwarzfuchs, Hila Zelicha, Lilac Tene, Anat Yaskolka Meir, Gal Tsaban, Noa Cohen, Nitzan Bril, Michal Rein, Dana Serfaty, Shira Kenigsbuch, Oded Komy, Arik Wolak, Yoash Chassidim, Rachel Golan, Hilla Avni-Hassid, Avital Bilitzky, Benjamin Sarusi, Eyal Goshen, Elad Shemesh, Yaakov Henkin, Michael Stumvoll, Matthias Blüher, Joachim Thiery, Uta Ceglarek, Assaf Rudich, Meir J Stampfer, Iris Shai
Background -We aimed to assess whether distinct lifestyle strategies can differentially affect specific body adipose depots. Methods -We performed an eighteen-month randomized controlled trial among 278 sedentary adults with abdominal obesity (75%) or dyslipidemia in an isolated workplace with a monitored provided lunch. Participants were randomized to iso-caloric low-fat (LF) or Mediterranean/low-carbohydrate (MED/LC) diet+28g walnuts/day with/without added moderate physical activity (PA;80% aerobic; supervised/free gym membership)...
November 15, 2017: Circulation
https://www.readbyqxmd.com/read/29141609/assessment-of-success-of-the-ponseti-method-of-clubfoot-management-in-sub-saharan-africa-a-systematic-review
#10
Tracey Smythe, Debra Mudariki, Hannah Kuper, Christopher Lavy, Allen Foster
BACKGROUND: Clubfoot is one of the most common congenital deformities affecting mobility. It leads to pain and disability if untreated. The Ponseti method is widely used for the correction of clubfoot. There is variation in how the result of clubfoot management is measured and reported. This review aims to determine and evaluate how success with the Ponseti method is reported in sub-Saharan Africa. METHODS: Five databases were examined in August 2017 for studies that met the inclusion criteria of: (1) evaluation of the effect of clubfoot management; (2) use of the Ponseti method; (3) original study undertaken in sub-Saharan Africa; (4) published between 2000 and 2017...
November 15, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/29141107/metal-transformation-as-a-strategy-for-bacterial-detoxification-of-heavy-metals
#11
Ashraf M M Essa, Mohamed A Al Abboud, Sayeed I Khatib
Microorganisms can modify the chemical and physical characters of metals leading to an alteration in their speciation, mobility, and toxicity. Aqueous heavy metals solutions (Hg, Cd, Pb, Ag, Cu, and Zn) were treated with the volatile metabolic products (VMPs) of Escherichia coli Z3 for 24 h using aerobic bioreactor. The effect of the metals treated with VMPs in comparison to the untreated metals on the growth of E. coli S1 and Staphylococcus aureus S2 (local isolates) was examined. Moreover, the toxic properties of the treated and untreated metals were monitored using minimum inhibitory concentration assay...
November 15, 2017: Journal of Basic Microbiology
https://www.readbyqxmd.com/read/29137992/ir-spectroscopy-analysis-of-pancreatic-lipase-related-protein-2-interaction-with-phospholipids-3-monitoring-dppc-lipolysis-in-mixed-micelles
#12
Eduardo Mateos-Diaz, Priscila Sutto-Ortiz, Moulay Sahaka, Jorge A Rodriguez, Frédéric Carrière
Usual methods for the continuous assay of lipolytic enzyme activities are mainly based on the titration of free fatty acids, surface pressure monitoring or spectrophotometry using substrates labeled with specific probes. These approaches only give a partial information on the chemistry of the lipolysis reaction and additional end-point analyses are often required to quantify both residual substrate and lipolysis products. We used transmission infrared (IR) spectroscopy to monitor simultaneously the hydrolysis of phospholipids by guinea pig pancreatic lipase-related protein 2 (GPLRP2) and the release of lipolysis products...
November 11, 2017: Chemistry and Physics of Lipids
https://www.readbyqxmd.com/read/29137840/resolvin-d1-attenuates-imiquimod-induced-mice-psoriasiform-dermatitis-through-mapks-and-nf-%C3%AE%C2%BAb-pathways
#13
Juntao Xu, Xiaoru Duan, Feng Hu, Devesh Poorun, Xinxin Liu, Xin Wang, Song Zhang, Lu Gan, Mengwen He, Ke Zhu, Zhangyin Ming, Hongxiang Chen
BACKGROUND: Resolvin D1 (RvD1), a pro-resolution lipid mediator derived from docosahexaenoic acid (DHA), has been described to promote several kinds of inflammatory resolution. However, the effects and anti-inflammatory mechanisms of RvD1 on psoriasis have not been previously reported. OBJECTIVE: The present study aimed to determine the protective effects and the underlying mechanisms of RvD1 on imiquimod (IMQ)-induced psoriasiform dermatitis. METHODS: Mice were topically treated with IMQ to develop psoriasiform dermatitis on their shaved back, pretreated intraperitoneally (i...
November 11, 2017: Journal of Dermatological Science
https://www.readbyqxmd.com/read/29137494/trh-receptor-mobility-in-the-plasma-membrane-is-strongly-affected-by-agonist-binding-and-by-interaction-with-some-cognate-signaling-proteins
#14
Radka Moravcova, Barbora Melkes, Jiri Novotny
OBJECTIVES: Extensive research has been dedicated to elucidating the mechanisms of signal transduction through different G protein-coupled receptors (GPCRs). However, relatively little is known about the regulation of receptor movement within the cell membrane upon ligand binding. In this study we focused our attention on the thyrotropin-releasing hormone (TRH) receptor that typically couples to Gq/11 proteins. METHODS: We monitored receptor diffusion in the plasma membrane of HEK293 cells stably expressing yellow fluorescent protein (YFP)-tagged TRH receptor (TRHR-YFP) by fluorescence recovery after photobleaching (FRAP)...
November 14, 2017: Journal of Receptor and Signal Transduction Research
https://www.readbyqxmd.com/read/29136817/rapid-quantification-of-persulfate-in-aqueous-systems-using-a-modified-hplc-unit
#15
Abbas Baalbaki, Nagham Zein Eddine, Saly Jaber, Maya Amasha, Antoine Ghauch
Existing analytical techniques used for the quantification of persulfate (PS) in water mostly rely on polarography, reductometry or spectrophotometry. Although acceptable to a certain extent, these methods did not satisfy environmental chemists seeking rapid, reproducible and accurate quantification of PS upon the application of ISCO and AOPs technologies. Accordingly, a novel flow injection/spectroscopy analytical technique is developed via the use of an HPLC coupled to bypass capillary columns and a DAD detector...
February 1, 2018: Talanta
https://www.readbyqxmd.com/read/29136049/-a-phd-completed-oral-health-care-and-oral-health-related-quality-of-life-of-frail-and-care-dependent-older-people
#16
D Niesten
When older people become frail, they often give up making dental visits, while their oral health care and oral health deteriorate. Open interviews and questionnaires were used to explore why frail older people change their oral health care behaviour and which (frailty-related) factors contribute to this change. These are mainly motivation-related factors. There seems to be a turning point where frail older people discontinue their oral health care routines and stop caring whether or not they loose teeth, because the perceived efforts no longer outweigh the perceived benefits of making dental visits and upkeep of oral hygiene...
November 2017: Nederlands Tijdschrift Voor Tandheelkunde
https://www.readbyqxmd.com/read/29136031/quantification-of-the-sit-to-stand-movement-for-monitoring-age-related-motor-deterioration-using-the-nintendo-wii-balance-board
#17
Go Yamako, Etsuo Chosa, Koji Totoribe, Yuu Fukao, Gang Deng
Simple methods for quantitative evaluations of individual motor performance are crucial for the early detection of motor deterioration. Sit-to-stand movement from a chair is a mechanically demanding component of activities of daily living. Here, we developed a novel method using the ground reaction force and center of pressure measured from the Nintendo Wii Balance Board to quantify sit-to-stand movement (sit-to-stand score) and investigated the age-related change in the sit-to-stand score as a method to evaluate reduction in motor performance...
2017: PloS One
https://www.readbyqxmd.com/read/29134138/mobile-acoustic-transects-miss-rare-bat-species-implications-of-survey-method-and-spatio-temporal-sampling-for-monitoring-bats
#18
Elizabeth C Braun de Torrez, Megan A Wallrichs, Holly K Ober, Robert A McCleery
Due to increasing threats facing bats, long-term monitoring protocols are needed to inform conservation strategies. Effective monitoring should be easily repeatable while capturing spatio-temporal variation. Mobile acoustic driving transect surveys ('mobile transects') have been touted as a robust, cost-effective method to monitor bats; however, it is not clear how well mobile transects represent dynamic bat communities, especially when used as the sole survey approach. To assist biologists who must select a single survey method due to resource limitations, we assessed the effectiveness of three acoustic survey methods at detecting species richness in a vast protected area (Everglades National Park): (1) mobile transects, (2) stationary surveys that were strategically located by sources of open water and (3) stationary surveys that were replicated spatially across the landscape...
2017: PeerJ
https://www.readbyqxmd.com/read/29133978/a-nationwide-structure-for-valid-long-term-oxygen-therapy-29-year-prospective-data-in-sweden
#19
Magnus Ekström, Zainab Ahmadi, Hillevi Larsson, Tove Nilsson, Josefin Wahlberg, Kerstin E Ström, Bengt Midgren
Background: Long-term oxygen therapy (LTOT) improves prognosis in COPD with severe hypoxemia. However, adherence to criteria for eligibility and quality of LTOT is often insufficient and varies between countries. The aim of this study was to evaluate a national structure for prescription and management of LTOT over three decades in Sweden. Methods: The study was a prospective, population-based study of 23,909 patients on LTOT from 1987 to 2015 in the Swedish National Register of Respiratory Failure (Swedevox)...
2017: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/29133859/conformal-transistor-arrays-based-on-solution-processed-organic-crystals
#20
Xiaoli Zhao, Bing Zhang, Qingxin Tang, Xueyan Ding, Shuya Wang, Yuying Zhou, Yanhong Tong, Yichun Liu
Conformal transistor array based on solution-processed organic crystals, which can provide sensory and scanning features for monitoring, biofeedback, and tracking of physiological function, presents one of the most promising technologies for future large-scale low-cost wearable and implantable electronics. However, it is still a huge challenge for the integration of solution-processed organic crystals into conformal FETs owing to a generally existing swelling phenomenon of the elastic materials and the lack of the corresponding device fabrication technology...
November 13, 2017: Scientific Reports
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