Nitsan Goldstein, Amadeus Maes, Heather N Allen, Tyler S Nelson, Kayla A Kruger, Morgan Kindel, Nicholas K Smith, Jamie R E Carty, Rachael E Villari, Ella Cho, Erin L Marble, Rajesh Khanna, Bradley K Taylor, Ann Kennedy, J Nicholas Betley
Long-term sustained pain in the absence of acute physical injury is a prominent feature of chronic pain conditions. While neurons responding to noxious stimuli have been identified, understanding the signals that persist without ongoing painful stimuli remains a challenge. Using an ethological approach based on the prioritization of adaptive survival behaviors, we determined that neuropeptide Y (NPY) signaling from multiple sources converges on parabrachial neurons expressing the NPY Y1 receptor to reduce sustained pain responses...
February 28, 2024: bioRxiv