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Grafting vitiligo

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https://www.readbyqxmd.com/read/28979623/-piebaldisme-a-rare-genodermatosis
#1
Fatima Zahra Debbarh, Fatima Zahra Mernissi
Piebaldism is a rare autosomal dominant genodermatosis. It is due to congenital absence of melanocytes in the affected areas. We report a case. A 5 year old girl born to consanguineous parents and with similar cases in her mother's; she presented since birth achromic lesions on the legs with a steady evolution. clinical examination showed confluent achromic macules and poliosis (A) with no contrast enhancement under Wood lamp and several coffee-with-milk colored spots on the trunk and thighs(B). The diagnosis of piebaldism was made...
2017: Pan African Medical Journal
https://www.readbyqxmd.com/read/28855688/maximizing-non-enzymatic-methods-for-harvesting-adipose-derived-stem-from-lipoaspirate-technical-considerations-and-clinical-implications-for-regenerative-surgery
#2
Barbara Bellei, Emilia Migliano, Marinella Tedesco, Silvia Caputo, Mauro Picardo
In the past decade, adipose tissue has become a highly interesting source of adult stem cells for plastic surgery and regenerative medicine. The adipose source offers two options for the isolation of regenerative cells: the enzymatic digestion an expensive time-consuming procedure lacking a common standard operating protocol, or the non-enzymatic dissociation methods based on mechanical forces to break the processed adipose tissue. Here, we propose innovative inexpensive non-enzymatic protocols to collect and concentrate clinically useful regenerative cells from adipose tissue by centrifugation of the infranatant fraction of lipoaspirate as first step, usually discarded as a byproduct of the surgical procedure, and by fat shaking and wash as second enrichment step...
August 30, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28852293/simplified-non-cultured-non-trypsinised-epidermal-cell-graft-technique-followed-by-psoralen-and-ultraviolet-a-light-therapy-for-stable-vitiligo
#3
Dilip Kachhawa, Pankaj Rao, Gyaneshwar Kalla
BACKGROUND AND AIMS: Stable vitiligo can be treated by various surgical procedures. Non-cultured melanocyte grafting techniques were developed to overcome the time-consuming process of culture while at the same time providing acceptable results. All the techniques using non-cultured melanocyte transfer involve trypsinisation as an integral step. Jodhpur technique used by the author is autologous, non-cultured, non-trypsinised, epidermal cell grafting. SETTINGS AND DESIGN: The study was conducted on patients visiting the dermatology outpatient department of a tertiary health centre in Western Rajasthan...
April 2017: Journal of Cutaneous and Aesthetic Surgery
https://www.readbyqxmd.com/read/28799192/wood-s-lamp-for-vitiligo-disease-stability-and-early-recognition-of-initiative-pigmentation-after-epidermal-grafting
#4
Yen-Jen Wang, Chang-Cheng Chang, Kun-Lin Cheng
The prerequisite for a successful vitiligo epidermal grafting surgery is the stable status of the disease. We used Wood's lamp to assess vitiligo activity to determine the disease stability, surgical grafting timing and the early recognition of re-pigmentation after grafting. Amelanotic lesions with sharply demarcated borders are typically stable and are good candidates for grafting. The re-pigmentation was first recognised under Wood's lamp as hypochromic islands, which progressed to normally pigmented islands...
August 10, 2017: International Wound Journal
https://www.readbyqxmd.com/read/28538029/autologous-biological-dressing-for-recipient-area-in-cellular-grafting-of-vitiligo
#5
Sanjeev Gupta, Ravi Shankar Jangra, Karalikkattil T Ashique, Somesh Gupta
No abstract text is available yet for this article.
May 22, 2017: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/28403523/autologous-cell-suspension-grafting-in-segmental-vitiligo-and-piebaldism-a-randomised-controlled-trial-comparing-full-surface-and-fractional-co2-laser-recipient-site-preparations
#6
J E Lommerts, A A Meesters, L Komen, M W Bekkenk, M A de Rie, R M Luiten, A Wolkerstorfer
BACKGROUND: Autologous non-cultured cell suspension transplantation is an effective treatment for repigmentation in segmental vitiligo and piebaldism. Full surface laser ablation is frequently used to prepare the recipient site before cell suspension transplantation, even though optimal laser settings and ablation depth are unknown. OBJECTIVES: To assess the efficacy and safety of less invasive recipient site preparations. METHODS: In a randomised, observer-blinded, controlled trial we compared different recipient site preparations before cell suspension transplantation in segmental vitiligo and piebaldism...
April 12, 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/28272910/punch-graft-versus-follicular-hair-transplantation-in-the-treatment-of-stable-vitiligo
#7
Essam-Elden Mohamed Mohamed, Abdel-Khalek Younes, Ahmed Osmand, Refaat Mohamed, Mahmoud Makki, Marwa Younis
OBJECTIVE: To compare the efficacy of follicular hair transplantation and mini punch graft in the treatment of stable vitiligo. METHODS: Thirty-two patients with stable vitiligo were included in this comparative study. A single patch from each patient was divided into two halves: one half was treated by punch graft, while the other half was treated by follicular hair transplantation followed by excimer light twice weekly, and the outcome was assessed at 0, 1, 3 and 6 months post operatively by photography and quartile scale...
October 2017: Journal of Cosmetic and Laser Therapy: Official Publication of the European Society for Laser Dermatology
https://www.readbyqxmd.com/read/28169015/janus-kinase-inhibitors-in-dermatology-a-systematic-review
#8
REVIEW
Rony Shreberk-Hassidim, Yuval Ramot, Abraham Zlotogorski
BACKGROUND: Janus kinase (JAK) inhibitors are emerging as a promising new treatment modality for many inflammatory conditions. OBJECTIVE: Our aim was to systematically review the available data on the use of JAK inhibitors in cutaneous diseases. METHODS: This is a systematic review of PubMed and ClinicalTrials.gov. RESULTS: One hundred thirty-four articles matched our search terms, of which 78 were original articles and 12 reports on adverse events...
April 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28163453/reduction-of-blister-formation-time-in-suction-blister-epidermal-grafting-in-vitiligo-patients-using-a-household-hair-dryer
#9
Shweta Arora, Bikash Ranjan Kar
BACKGROUND: Suction blister epidermal grafting (SBEG) is a simple and effective way of surgical repigmentation in vitiligo. The major problem faced is the time taken for the formation of blisters. Temperature at the suction site is one of the factors affecting the blister formation time. AIMS AND OBJECTIVES: To reduce the blister formation time in SBEG by increasing the surface temperature to 44°C. MATERIALS AND METHODS: This is a left-right comparison study...
October 2016: Journal of Cutaneous and Aesthetic Surgery
https://www.readbyqxmd.com/read/28157763/effect-of-procedural-related-variables-on-melanocyte-keratinocyte-suspension-transplantation-in-nonsegmental-stable-vitiligo-a-clinical-and-immunocytochemical-study
#10
MULTICENTER STUDY
Bakr Mohamed El-Zawahry, Samia Esmat, Dalia Bassiouny, Naglaa Sameh Zaki, Rehab Sobhi, Marwah A Saleh, Dalia Abdel-Halim, Rehab Hegazy, Heba Gawdat, Nesrin Samir, Marwa El-Hawary, Zeinab El Maadawi, Heba Gouda, Mervat Khorshied
BACKGROUND: Melanocyte-keratinocyte suspension (M-K susp) is gaining popularity for vitiligo treatment. Few studies have addressed procedure-related variables. OBJECTIVE: To assess the effect of different M-K susp procedure-related variables on the clinical outcome in stable vitiligo. METHODS: This prospective multicenter comparative study included 40 cases with nonsegmental stable vitiligo. Donor site was either a skin graft in noncultured epidermal cell suspension (NCECS) or hair follicle units in outer root sheath hair follicle suspension (ORSHFS)...
February 2017: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/28157762/ultrathin-skin-grafting-in-resistant-stable-vitiligo-a-follow-up-study-of-8-years-in-370-patients
#11
Imran Majid, Saher Imran
BACKGROUND: Ultrathin skin grafting (UTSG) is a tissue grafting technique used in resistant stable vitiligo. OBJECTIVE: To assess long-term follow-up results achieved with UTSG in vitiligo. METHODS: Over a span of 8 years, a total of 415 patients with stable vitiligo were treated with UTSG at the authors' institute. Retrospective analysis of results achieved in these patients was performed, and primary end points assessed included the extent and quality of repigmentation achieved and adverse effects from the procedure...
February 2017: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/28003945/autologous-epidermal-grafting-using-a-novel-negative-pressure-epidermal-harvesting-system-in-a-case-of-stable-vitiligo
#12
Aarthi Krishna, Vanathi Thirunavukkarasu, Paru Priyadarshini Navaneetha Krishnan, Nithya Gayathri Devi Danasekaran, Ratnavel Rajendrabose
Vitiligo is a common pigmentary disorder of the skin with a great amount of social stigma attached to it. Though various medical modalities are available for the treatment of stable vitiligo, surgical modality remains the treatment of choice for stable and localized vitiligo. The surgical options range from simple punch grafting to the recent epidermal harvesting methods using a negative pressure unit. Although successful use of multiple methods of epidermal grafting has been reported, most of them are cumbersome and time-consuming...
November 15, 2016: Curēus
https://www.readbyqxmd.com/read/27904182/comparative-study-of-efficacy-of-epidermal-melanocyte-transfer-versus-hair-follicular-melanocyte-transfer-in-stable-vitiligo
#13
Navya Donaparthi, Ajay Chopra
BACKGROUND: Vitiligo surgery has come up a long way from punch skin grafts to epidermal cell suspension and latest to the extracted hair follicle outer root sheath cell suspension (EHFORSCS) transplantation. The progressive development from one technique to the other is always on a quest for the best. In the latest development, EHFORSCS, which is an enriched source of follicular inactive melanocyte (melanocyte stem cells), seems to be a good addition to the prevailing cell-based therapies for vitiligo...
November 2016: Indian Journal of Dermatology
https://www.readbyqxmd.com/read/27601859/a-study-of-noncultured-extracted-hair-follicle-outer-root-sheath-cell-suspension-for-transplantation-in-vitiligo
#14
Aarti N Shah, Ritu K Marfatia, Siddhartha S Saikia
CONTEXT: Vitiligo surgeries have come a long way from tissue grafts to cultured and non cultured cell transplantation. Extracted hair follicle outer root sheath cell transplantation (EHF ORS) suspension is more enriched with melanocyte. In a hair bulb, there is one melanocyte for every five keratinocytes which is much higher than the epidermal melanin unit. AIMS: To analyse the effectiveness of cultured EHF ORS and to perform objective evaluation based on clinical improvement & photographic evidence...
April 2016: International Journal of Trichology
https://www.readbyqxmd.com/read/27560291/fractional-co2-laser-pretreatment-to-autologous-hair-transplantation-and-phototherapy-improves-perifollicular-repigmentation-in-refractory-vitiligo-a-randomized-prospective-half-lesion-comparative-study
#15
RANDOMIZED CONTROLLED TRIAL
Amir Feily, Vahid Seifi, Marigdalia K Ramirez-Fort
BACKGROUND: Fractional CO2 laser and autologous hair transplantation are independently effective in the treatment of refractory and stable vitiligo. OBJECTIVE: The authors' purpose was to evaluate the therapeutic efficacy of fractional CO2 laser pretreatment compared with autologous hair transplantation and phototherapy alone for refractory and stable vitiligo. METHODS: A total of 20 patients with refractory and stable vitiligo were enrolled from our clinic...
September 2016: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/27547963/epidermal-skin-grafting-in-vitiligo-a-pilot-study
#16
Agata Janowska, Valentina Dini, Salvatore Panduri, Michela Macchia, Teresa Oranges, Marco Romanelli
Vitiligo is a multifactorial acquired dermatosis characterised by achromic or hypochromic macules and by the absence of functioning melanocytes. Treatment depends on the extent of the affected areas and on disease activity. Surgical techniques have proven to be effective in stable cases but can be time-consuming and, in some cases, aesthetically unsatisfying or painful for the patients. The aim of the study was to assess the clinical safety and effectiveness of a new automatic epidermal skin harvesting device in patients with stable localised vitiligo over a minimum 12-month period...
September 2016: International Wound Journal
https://www.readbyqxmd.com/read/27538731/glabrous-lesional-stem-cells-differentiated-into-functional-melanocytes-new-hope-for-repigmentation
#17
R Kumar, D Parsad, S Rani, S Bhardwaj, N Srivastav
BACKGROUND: Vitiligo is characterized by the loss of pigment-producing cells, melanocytes and one of the important goals of treatment is replenishing the melanocytes from existing reservoirs. Reservoir for melanocyte stem cell has been reported to be present in the skin hair follicles, but glabrous skin does not have hair follicles. Therefore, repigmentation of glabrous lesional skin is very difficult and almost rare. There is no explanation for melanocyte reservoir in the glabrous lesional skin of vitiligo patients...
September 2016: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/27374824/high-frequency-of-cutaneous-manifestations-including-vitiligo-and-alopecia-areata-in-a-prospective-cohort-of-patients-with-chronic-graft-vs-host-disease
#18
Romana Čeović, Lana Desnica, Dražen Pulanić, Ranka Serventi Seiwerth, Ivana Ilić, Magdalena Grce, Marinka Mravak Stipetić, Tajana Klepac Pulanić, Ervina Bilić, Ernest Bilić, Milan Milošević, Radovan Vrhovac, Damir Nemet, Steven Z Pavletic
AIM: To determine the frequency and the characteristics of cutaneous manifestations, especially vitiligo and alopecia areata, in patients with chronic graft-vs-host disease (cGVHD). METHODS: 50 patients with cGVHD were prospectively enrolled in the observational study protocol and evaluated by an experienced dermatologist. The evaluation was focused on the clinical spectrum of skin and adnexal involvement, and the cutaneous GVHD score was determined according to National Institutes of Health (NIH) Consensus criteria...
June 30, 2016: Croatian Medical Journal
https://www.readbyqxmd.com/read/27369365/depigmentation-during-vitiligo-activity-spares-epithelial-grafted-areas
#19
Sherif Shoukry Awad
BACKGROUND: Vitiligo is a depigmenting disease characterized by episodes of stability and activity without a fixed sequence, and active phases demonstrate immune attacks toward vulnerable melanocytes. Epithelial grafts were introduced to treat recalcitrant vitiligo patches aiming to provide new generations of melanocytes. AIMS: The aim of study was to evaluate the possible permanency of succeeded epithelial grafts during a coming activity episode. METHODS: This study included 20 nonsegmental vitiligo cases...
December 2016: Journal of Cosmetic Dermatology
https://www.readbyqxmd.com/read/27309418/optimising-size-and-depth-of-punch-grafts-in-autologous-transplantation-of-vitiligo-and-piebaldism-a-randomised-controlled-trial
#20
RANDOMIZED CONTROLLED TRIAL
Lisa Komen, Charlotte Vrijman, Cecilia A C Prinsen, J P Wietze van der Veen, Rosalie M Luiten, Albert Wolkerstorfer
BACKGROUND: To date, autologous punch grafting appears to be the easiest and least expensive surgical technique for stable vitiligo and piebaldism. Punch grafting is available worldwide, with no need for specialised instruments. However, no reliable data on efficacy and safety of different punch depths and punch sizes are available. OBJECTIVE/METHODS: To compare the efficacy and safety of different punch depths and punch sizes in autologous punch grafting, a randomised controlled trial was performed in 33 patients with vitiligo or piebaldism...
February 2017: Journal of Dermatological Treatment
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