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Grafting vitiligo

Aarti N Shah, Ritu K Marfatia, Siddhartha S Saikia
CONTEXT: Vitiligo surgeries have come a long way from tissue grafts to cultured and non cultured cell transplantation. Extracted hair follicle outer root sheath cell transplantation (EHF ORS) suspension is more enriched with melanocyte. In a hair bulb, there is one melanocyte for every five keratinocytes which is much higher than the epidermal melanin unit. AIMS: To analyse the effectiveness of cultured EHF ORS and to perform objective evaluation based on clinical improvement & photographic evidence...
April 2016: International Journal of Trichology
Amir Feily, Vahid Seifi, Marigdalia K Ramirez-Fort
BACKGROUND: Fractional CO2 laser and autologous hair transplantation are independently effective in the treatment of refractory and stable vitiligo. OBJECTIVE: The authors' purpose was to evaluate the therapeutic efficacy of fractional CO2 laser pretreatment compared with autologous hair transplantation and phototherapy alone for refractory and stable vitiligo. METHODS: A total of 20 patients with refractory and stable vitiligo were enrolled from our clinic...
September 2016: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
Agata Janowska, Valentina Dini, Salvatore Panduri, Michela Macchia, Teresa Oranges, Marco Romanelli
Vitiligo is a multifactorial acquired dermatosis characterised by achromic or hypochromic macules and by the absence of functioning melanocytes. Treatment depends on the extent of the affected areas and on disease activity. Surgical techniques have proven to be effective in stable cases but can be time-consuming and, in some cases, aesthetically unsatisfying or painful for the patients. The aim of the study was to assess the clinical safety and effectiveness of a new automatic epidermal skin harvesting device in patients with stable localised vitiligo over a minimum 12-month period...
September 2016: International Wound Journal
R Kumar, D Parsad, S Rani, S Bhardwaj, N Srivastav
BACKGROUND: Vitiligo is characterized by the loss of pigment-producing cells, melanocytes and one of the important goals of treatment is replenishing the melanocytes from existing reservoirs. Reservoir for melanocyte stem cell has been reported to be present in the skin hair follicles, but glabrous skin does not have hair follicles. Therefore, repigmentation of glabrous lesional skin is very difficult and almost rare. There is no explanation for melanocyte reservoir in the glabrous lesional skin of vitiligo patients...
September 2016: Journal of the European Academy of Dermatology and Venereology: JEADV
Romana Čeović, Lana Desnica, Dražen Pulanić, Ranka Serventi Seiwerth, Ivana Ilić, Magdalena Grce, Marinka Mravak Stipetić, Tajana Klepac Pulanić, Ervina Bilić, Ernest Bilić, Milan Milošević, Radovan Vrhovac, Damir Nemet, Steven Z Pavletic
AIM: To determine the frequency and the characteristics of cutaneous manifestations, especially vitiligo and alopecia areata, in patients with chronic graft-vs-host disease (cGVHD). METHODS: 50 patients with cGVHD were prospectively enrolled in the observational study protocol and evaluated by an experienced dermatologist. The evaluation was focused on the clinical spectrum of skin and adnexal involvement, and the cutaneous GVHD score was determined according to National Institutes of Health (NIH) Consensus criteria...
June 30, 2016: Croatian Medical Journal
Sherif Shoukry Awad
BACKGROUND: Vitiligo is a depigmenting disease characterized by episodes of stability and activity without a fixed sequence, and active phases demonstrate immune attacks toward vulnerable melanocytes. Epithelial grafts were introduced to treat recalcitrant vitiligo patches aiming to provide new generations of melanocytes. AIMS: The aim of study was to evaluate the possible permanency of succeeded epithelial grafts during a coming activity episode. METHODS: This study included 20 nonsegmental vitiligo cases...
July 1, 2016: Journal of Cosmetic Dermatology
Lisa Komen, Charlotte Vrijman, Cecilia A C Prinsen, J P Wietze van der Veen, Rosalie M Luiten, Albert Wolkerstorfer
BACKGROUND: To date, autologous punch grafting appears to be the easiest and least expensive surgical technique for stable vitiligo and piebaldism. Punch grafting is available worldwide, with no need for specialised instruments. However, no reliable data on efficacy and safety of different punch depths and punch sizes are available. OBJECTIVE/METHODS: To compare the efficacy and safety of different punch depths and punch sizes in autologous punch grafting, a randomised controlled trial was performed in 33 patients with vitiligo or piebaldism...
June 16, 2016: Journal of Dermatological Treatment
Divya Shokeen
Vitiligo is an acquired depigmentation disorder of unknown etiology. Medical treatments are usually reasonably effective for nonstable vitiligo patches; however, for vitiligo patches that have been stable for a substantial period of time, surgical intervention should be considered. In this article, surgical interventions for vitiligo are reviewed, including split-thickness skin grafting, suction blister grafting, miniature punch grafting, and cultured melanocyte transplantation.
May 2016: Cutis; Cutaneous Medicine for the Practitioner
Dinesh Kadam
The quest for skin expansion is not restricted to cover a large area alone, but to produce acceptable uniform surfaces, robust engraftment to withstand mechanical shear and infection, with a minimal donor morbidity. Ease of the technique, shorter healing period and reproducible results are essential parameters to adopt novel techniques. Significant advances seen in four fronts of autologous grafting are: (1) Dermal-epidermal graft expansion techniques, (2) epidermal graft harvests technique, (3) melanocyte-rich basal cell therapy for vitiligo and (4) robust and faster autologous cell cultures...
January 2016: Indian Journal of Plastic Surgery: Official Publication of the Association of Plastic Surgeons of India
Emily Yiping Gan, Yan Ling Kong, Wei Ding Tan, Steven T Thng, Boon Kee Goh
BACKGROUND: Noncultured cellular grafting is a known surgical technique for vitiligo. OBJECTIVE: This study evaluated our center's 12-month repigmentation outcome and its maintenance up to 60 months, factors influencing repigmentation and safety data. METHODS: Clinicoepidemiologic and repigmentation data were reviewed for patients with vitiligo who had undergone noncultured cellular grafting from March 2006 to December 2012 at the National Skin Center, Singapore...
September 2016: Journal of the American Academy of Dermatology
Haneol S Jeong, Travis Vandergriff, Amit G Pandya
No abstract text is available yet for this article.
May 2016: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
Imran Majid, Venkataram Mysore, Thurakkal Salim, Koushik Lahiri, Manas Chatterji, Niti Khunger, Suresh Talwar, S Sachhidanand, Shyamanta Barua
BACKGROUND: Ensuring stability of the disease process is essential for undertaking surgical intervention in vitiligo. However, there is no consensus regarding the minimum duration of stability or the relative importance of disease and lesional stability in selecting patients for vitiligo grafting. AIM: This multicentric study aims to assess the relative importance of lesional and disease stability on selecting patients for vitiligo grafting. MATERIALS AND METHODS: One hundred seventy patients were recruited into the study and divided into two groups: Group A with lesional stability of >1 year but overall disease stability of only 6-11 months and Group B with overall disease stability of >1 year...
January 2016: Journal of Cutaneous and Aesthetic Surgery
Dongyun Shin, Sang Ho Oh, Seung-Kyung Hann
No abstract text is available yet for this article.
April 2016: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
Simone M Goldinger, Pascale Stieger, Barbara Meier, Sara Micaletto, Emmanuel Contassot, Lars E French, Reinhard Dummer
PURPOSE: Immunotherapy has experienced impressive progress in cancer treatment. Antibodies against PD-1 improved survival in different types of cancer including melanoma. They are generally well tolerated. However, skin toxicities including pruritus, rashes, and vitiligo are reported. Although frequent, they have not been characterized further yet. In this analysis, we aimed to systematically assess and characterize the adverse cutaneous reactions observed in patients with melanoma treated with anti-PD-1 antibodies...
August 15, 2016: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
Amit Kumar Srivastava, Piush Khare, Hemant Kumar Nagar, Navdeep Raghuwanshi, Rajnish Srivastava
Hydroxyproline is a non-essential amino acid found in collagen and few other extracellular animal proteins. It's two isomeric forms trans-4-hydroxy-L-proline and trans-3-hydroxy-L-proline play a crucial role in collagen synthesis and thermodynamic stability of the triple-helical conformation of collagen and associated tissues. Various abnormalities in hydroxyproline metabolism have been shown to play key roles in the pathophysiology and pathogenesis of different diseases. The elevated level of hydroxyproline is observed in several disorders, e...
2016: Current Protein & Peptide Science
Parul Thakur, S Sacchidanand, H V Nataraj, A S Savitha
BACKGROUND: Repigmentation of vitiligo is closely related to hair follicles. Hence, replenishing melanocytes in vitiliginous patches utilizing undifferentiated stem cells of the hair follicles using follicular unit transplantation (FUT) is a possible treatment option. OBJECTIVES OF THE STUDY: To study the efficacy of FUT in cases of segmental/stabilized vitiligo as a treatment option for leukotrichia. MATERIALS AND METHODS: Fifty patients with 63 lesions of stable vitiligo over nonglabrous areas were treated with follicular unit grafts...
October 2015: Journal of Cutaneous and Aesthetic Surgery
Sihyeok Jang, In Su Kim, Sang Woong Youn
Graft-versus-host disease (GVHD) is a common complication of bone marrow transplantation (BMT) that can be classified as acute or chronic. Chronic GVHD, which usually occurs more than 3 months after BMT, includes typical lichenoid or sclerodermatous lesions. Psoriasiform eruption is a rare clinical manifestation of chronic GVHD, and there have been no reports of psoriasiform chronic GVHD associated with hemophagocytic lymphohistiocytosis. A 33-year-old woman who was diagnosed with hemophagocytic lymphohistiocytosis 10 years ago visited our outpatient clinic with psoriasiform eruption over her entire body...
February 2016: Annals of Dermatology
Kyoichi Matsuzaki, Tomohiro Chiyokura, Norio Kumagai
No abstract text is available yet for this article.
January 2016: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
Joana C O Carvalho, Jonathan A Palero, Martin Jurna
Separation of skin epidermis from the dermis by suction blistering has been used with high success rate for autologous skin epidermal grafting in burns, chronic wounds and vitiligo transplantation treatment. Although commercial products that achieve epidermal grafting by suction blistering are presently available, there is still limited knowledge and understanding on the dynamic process of epidermal-dermal separation during suction blistering. In this report we integrated a suction system to an Optical Coherence Tomography (OCT) which allowed for the first time, real-time imaging of the suction blistering process in human skin...
December 1, 2015: Biomedical Optics Express
Naoki Oiso, Akira Kawada
No abstract text is available yet for this article.
January 2016: European Journal of Dermatology: EJD
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