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https://www.readbyqxmd.com/read/28743070/tracking-binding-modes-of-1-2-4-trisubstituted-imidazolinone-p38-map-kinase-and-erk-2-inhibitors
#1
Shashidhar N Rao
Putative binding modes of recently reported p38 MAP Kinase and ERK-2 inhibitors containing 1,2,4-tri-substituted imidazolinone have been investigated using molecular docking methods In the case of p38 MAP Kinase, X-ray structures with both DFG-in and DFG-out conformations of the activation loop have been employed for docking studies. The present investigations demonstrate that the DFG-out conformation of the activation loop in p38 MAP Kinase accommodates the 1,2,4-tri-substituted imidazolinones with greater computed binding affinities than the alternative DFG-in conformation...
July 4, 2017: Journal of Molecular Graphics & Modelling
https://www.readbyqxmd.com/read/28742955/bayesian-one-step-ipd-network-meta-analysis-of-time-to-event-data-using-royston-parmar-models
#2
Suzanne C Freeman, James R Carpenter
Network meta-analysis (NMA) combines direct and indirect evidence from trials to calculate and rank treatment estimates. While modelling approaches for continuous and binary outcomes are relatively well developed, less work has been done with time-to-event outcomes. Such outcomes are usually analysed using Cox proportional hazard (PH) models. However, in oncology with longer follow-up time, and time-dependent effects of targeted treatments, this may no longer be appropriate. Network meta-analysis conducted in the Bayesian setting has been increasing in popularity...
July 25, 2017: Research Synthesis Methods
https://www.readbyqxmd.com/read/28742765/on-the-job-productivity-losses-among-employees-with-health-problems-the-role-of-work-accommodations
#3
Brian Gifford, Yang Zong
OBJECTIVES: Debates about the productivity impact of work accommodations typically focus on employment and labor force participation outcomes. This study considers whether accommodations mediate on-the-job productivity losses among employees who report health problems. METHODS: The study uses ordered logistic regression to predict employees' self-reported productivity losses as a function of health problems and experiences with needed work accommodations. RESULTS: On average, the odds that an employee who did not get a needed accommodation reported higher levels of lost productivity are 5...
July 24, 2017: Journal of Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/28741999/deakozyma-yunnanensis-sp-nov-a-novel-yeast-species-isolated-from-rotten-wood
#4
Jun Zheng, Kai-Fang Liu, Xiao-Jing Liu, Lin Zhang, Feng-Li Hui
Three strains representing a novel yeast species were isolated from rotten wood samples collected in Xishuangbanna Tropical Rainforest in Yunnan Province, PR China. Sequence analysis of the D1/D2 domains of the large subunit (LSU) rRNA gene and the internal transcribed spacer (ITS) regions indicated that the novel species represented a member of the genus Deakozyma. The novel species was related most closely to the type strain of Deakozyma indianensis but they differed by 5.8 % sequence divergence (20 substitutions and 5 gaps) in the D1/D2 domain and by 12...
July 21, 2017: International Journal of Systematic and Evolutionary Microbiology
https://www.readbyqxmd.com/read/28741400/high-prevalence-of-dysgraphia-in-elementary-through-high-school-students-with-adhd-and-autism
#5
Susan D Mayes, Rosanna P Breaux, Susan L Calhoun, Sara S Frye
OBJECTIVE: Prevalence of dysgraphia by age across all grade levels was determined in students with ADHD or autism. METHOD: Referred children with normal intelligence and ADHD-Combined, ADHD-Inattentive, or autism ( N = 1,034) were administered the Developmental Test of Visual-Motor Integration (VMI) and Wechsler Intelligence Scale for Children (WISC). RESULTS: VMI and WISC Coding scores were significantly lower than IQ and the normal mean of 100 for all diagnoses...
July 1, 2017: Journal of Attention Disorders
https://www.readbyqxmd.com/read/28740400/multidisciplinary-care-of-craniosynostosis
#6
REVIEW
Edward P Buchanan, Yunfeng Xue, Amy S Xue, Asaf Olshinka, Sandi Lam
The management of craniosynostosis, especially in the setting of craniofacial syndromes, is ideally done in a multidisciplinary clinic with a team focused toward comprehensive care. Craniosynostosis is a congenital disorder of the cranium, caused by the premature fusion of one or more cranial sutures. This fusion results in abnormal cranial growth due to the inability of the involved sutures to accommodate the growing brain. Skull growth occurs only at the patent sutures, resulting in an abnormal head shape...
2017: Journal of Multidisciplinary Healthcare
https://www.readbyqxmd.com/read/28739800/cell-free-production-of-a-functional-oligomeric-form-of-a-chlamydia-major-outer-membrane-protein-momp-for-vaccine-development
#7
Wei He, Martina Felderman, Angela C Evans, Jia Geng, David Homan, Feliza Bourguet, Nicholas O Fischer, Yuanpei Li, Kit S Lam, Aleksandr Noy, Li Xing, R Holland Cheng, Amy Rasley, Craig D Blanchette, Kurt Kamrud, Nathanial Wang, Heather Gouvis, Todd C Peterson, Bolyn Hubby, Matthew A Coleman
Chlamydia is a prevalent sexually transmitted disease that infects more than 100 million people worldwide. Although most individuals infected with Chlamydia trachomatis are initially asymptomatic, symptoms can arise if left undiagnosed. Long-term infection can result in debilitating conditions such as pelvic inflammatory disease, infertility, and blindness. Chlamydia infection, therefore, constitutes a significant public health threat, underscoring the need for a Chlamydia-specific vaccine. Chlamydia strains express a major outer-membrane protein (MOMP) that has been shown to be an effective vaccine antigen...
July 24, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28739781/structural-insights-into-the-tla-3-extended-spectrum-%C3%AE-lactamase-and-its-inhibition-by-avibactam-and-op0595
#8
Wanchun Jin, Jun-Ichi Wachino, Yoshihiro Yamaguchi, Kouji Kimura, Anupriya Kumar, Mototsugu Yamada, Akihiro Morinaka, Yoshiaki Sakamaki, Minoru Yonezawa, Hiromasa Kurosaki, Yoshichika Arakawa
Development of effective inhibitors that block extended-spectrum β-lactamases (ESBLs) and restore the action of β-lactams represents an effective strategy against ESBL-producing Enterobacteriaceae We evaluated the inhibitory effect of the diazabicyclooctanes avibactam and OP0595 against TLA-3, an ESBL we identified previously. Avibactam and OP0595 inhibited TLA-3 with apparent Ki app of 1.71 ± 0.10 and 1.49 ± 0.05 μM, respectively, and could restore susceptibility to cephalosporins in TLA-3-producing Escherichia coli The acylation rate constant [k2/K, (3...
July 24, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28738789/the-impact-of-indigenous-cultural-identity-and-cultural-engagement-on-violent-offending
#9
Stephane M Shepherd, Rosa Hazel Delgado, Juanita Sherwood, Yin Paradies
BACKGROUND: Possessing a strong cultural identity has been shown to protect against mental health symptoms and buffer distress prompted by discrimination. However, no research to date has explored the protective influences of cultural identity and cultural engagement on violent offending. This paper investigates the relationships between cultural identity/engagement and violent recidivism for a cohort of Australian Indigenous people in custody. METHODS: A total of 122 adults from 11 prisons in the state of Victoria completed a semi-structured interview comprising cultural identification and cultural engagement material in custody...
July 24, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28738463/-a-cross-sectional-study-on-dyslipidemia-in-migrants-in-inner-mongolia-autonomous-region
#10
T Zhang, Q Zhou, Y G Qian, J Zhou, S J Wu, P Y Wang, A P Liu
Objective: To investigate the prevalence of dyslipidemia in migrants in Inner Mongolia Autonomous Region. Methods: A stratified multi-stage cluster equal size sampling was performed among the migrants aged ≥18 years who were engaged in manufacturing, wholesale retail, accommodation and catering service, social service, construction and other and 1 501 migrants from five area in Inner Mongolia Autonomous Region was investigated by means of questionnaires survey, physical measurements and laboratory detection...
July 10, 2017: Zhonghua Liu Xing Bing Xue za Zhi, Zhonghua Liuxingbingxue Zazhi
https://www.readbyqxmd.com/read/28738199/acute-ecotoxicity-of-coated-colloidal-goethite-nanoparticles-on-daphnia-magna-evaluating-the-influence-of-exposure-approaches
#11
V González-Andrés, M Diez-Ortiz, C Delpivo, G Janer, A Fritzsche, S Vázquez-Campos
Synthesized iron oxide nanoparticles have been proposed as an alternative to non-dispersed iron oxides for in situ environmental remediation. Their colloidal properties enable their injection into porous media, i.e. soils and aquifers, and offer a higher efficiency in removing contaminants. However, this dispersed state is also the cause of concerns over their environmental fate and toxicity, e.g., by increasing the exposure time to aquatic organisms in groundwater remediation activities. Therefore, the objective of in situ groundwater remediation is to establish local reactive barriers in the subsurface by injection by means of reactive colloids with a controllable mobility under in situ conditions and present as colloids as shortly as possible...
July 21, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28737706/redox-properties-of-tryptophan-metabolism-and-the-concept-of-tryptophan-use-in-pregnancy
#12
REVIEW
Kang Xu, Hongnan Liu, Miaomiao Bai, Jing Gao, Xin Wu, Yulong Yin
During pregnancy, tryptophan (Trp) is required for several purposes, and Trp metabolism varies over time in the mother and fetus. Increased oxidative stress (OS) with high metabolic, energy and oxygen demands during normal pregnancy or in pregnancy-associated disorders has been reported. Taking the antioxidant properties of Trp and its metabolites into consideration, we made four hypotheses. First, the use of Trp and its metabolites is optional based on their antioxidant properties during pregnancy. Second, dynamic Trp metabolism is an accommodation mechanism in response to OS...
July 24, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28736571/evaluation-of-quality-assessment-protocols-for-high-throughput-genome-resequencing-data
#13
REVIEW
Matteo Chiara, Giulio Pavesi
Large-scale initiatives aiming to recover the complete sequence of thousands of human genomes are currently being undertaken worldwide, concurring to the generation of a comprehensive catalog of human genetic variation. The ultimate and most ambitious goal of human population scale genomics is the characterization of the so-called human "variome," through the identification of causal mutations or haplotypes. Several research institutions worldwide currently use genotyping assays based on Next-Generation Sequencing (NGS) for diagnostics and clinical screenings, and the widespread application of such technologies promises major revolutions in medical science...
2017: Frontiers in Genetics
https://www.readbyqxmd.com/read/28736459/final-report-on-the-key-comparison-ccm-p-k15-in-the-pressure-range-from-1-0-%C3%A3-10-4-pa-to-1-0-pa
#14
Christian Wuethrich, Kenta Arai, Mercede Bergoglio, James A Fedchak, Karl Jousten, Seung Soo Hong, Jorge Torres Guzman
The comparison CCM.P-K15 is a key comparison in pressure involving six laboratories in three regional metrological organizations (RMO). The measurand of the comparison is the accommodation coefficient of two spinning rotating gauge characterized in nitrogen from 0.1 mPa up to 1.0 Pa. The two transfer standards were circulated from November 2009 until March 2011. The circulation consisted of three loops, one for each RMO, and a new calibration by the pilot between each loop. The stability of one of the transfer standards was poor and was worse than expected based on the previous history of the transfer standard while the other transfer standard demonstrated good stability while circulated in Europe and America and a fair stability while circulated in Asia...
2017: Metrologia
https://www.readbyqxmd.com/read/28736422/choosing-accommodations-signed-language-interpreting-and-the-absence-of-choice
#15
Teresa Blankmeyer Burke
This paper carves out a topic space for discussion about the ethical question of whether input from signing Deaf consumers of interpreting services ought to be included in the provision of signed language interpreter accommodations. The first section provides background about disability accommodations and practices, including how signed language interpreting accommodations are similar and dissimilar to other kinds of disability accommodations. In the second section, I offer a personal narrative of my experience as a Deaf academic who has been excluded from the interpreter selection process, highlighting some of the harmful consequences of such exclusion...
2017: Kennedy Institute of Ethics Journal
https://www.readbyqxmd.com/read/28734836/criticality-in-the-brain-a-synthesis-of-neurobiology-models-and-cognition
#16
REVIEW
Luca Cocchi, Leonardo L Gollo, Andrew Zalesky, Michael Breakspear
Cognitive function requires the coordination of neural activity across many scales, from neurons and circuits to large-scale networks. As such, it is unlikely that an explanatory framework focused upon any single scale will yield a comprehensive theory of brain activity and cognitive function. Modelling and analysis methods for neuroscience should aim to accommodate multiscale phenomena. Emerging research now suggests that multi-scale processes in the brain arise from so-called critical phenomena that occur very broadly in the natural world...
July 19, 2017: Progress in Neurobiology
https://www.readbyqxmd.com/read/28734683/health-seeking-behavior-and-medical-facility-choice-in-samsun-turkey
#17
Cihad Dündar
OBJECTIVE: Examining the factors that play a role in determining patient preferences for different healthcare institutions. METHOD: This descriptive study was conducted in five family health centers (FHC) and in six hospitals in Samsun Province in Turkey. The data were collected from 1700 volunteer patients by using a structured questionnaire, while they were waiting for consultation. RESULT: The average number of out-patient visits was 9...
July 12, 2017: Health Policy
https://www.readbyqxmd.com/read/28734286/communication-light-driven-remote-control-of-microgels-size-in-the-presence-of-photosensitive-surfactant-complete-phase-diagram
#18
Selina Schimka, Yulia D Gordievskaya, Nino Lomadze, Maren Lehmann, Regine von Klitzing, Artem M Rumyantsev, Elena Yu Kramarenko, Svetlana Santer
Here we report on a light triggered remote control of microgel size in the presence of photosensitive surfactant. The hydrophobic tail of the cationic surfactant contains azobenzene group that undergoes a reversible photo-isomerization reaction from a trans- to a cis-state accompanied by a change in the hydrophobicity of the surfactant. We have investigated light assisted behaviour and the complex formation of the microgels with azobenzene containing surfactant over the broad concentrational range starting far below and exceeding several times of the critical micelle concentration (CMC)...
July 21, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/28734257/comparison-of-femoropopliteal-artery-stents-under-axial-and-radial-compression-axial-tension-bending-and-torsion-deformations
#19
Kaspars Maleckis, Paul Deegan, William Poulson, Cole Sievers, Anastasia Desyatova, Jason MacTaggart, Alexey Kamenskiy
High failure rates of Peripheral Arterial Disease (PAD) stenting appear to be associated with the inability of certain stent designs to accommodate severe biomechanical environment of the femoropopliteal artery (FPA) that bends, twists, and axially compresses during limb flexion. Twelve Nitinol stents (Absolute Pro, Supera, Lifestent, Innova, Zilver, Smart Control, Smart Flex, EverFlex, Viabahn, Tigris, Misago, and Complete SE) were quasi-statically tested under bench-top axial and radial compression, axial tension, bending, and torsional deformations...
July 13, 2017: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/28733595/how-cholesteryl-ester-transfer-protein-can-also-be-a-potential-triglyceride-transporter
#20
Venkat R Chirasani, Sanjib Senapati
CETP transfers cholesteryl esters (CEs) and triglycerides (TGs) between different lipoproteins and came in limelight as a drug-target against CVD. In the search for detailed mechanism of lipid transfer through CETP, enormous effort is devoted employing crystallographic, cryo-EM, and Molecular Dynamics (MD) studies. However, these studies primarily focused on CE-bound CETP structure and CE transfer mechanism. With the reported correlation that CETP looses significant CE transfer activity upon inhibiting TG transfer, it is of tremendous importance to understand the structure and dynamics of TG-bound CETP...
July 21, 2017: Scientific Reports
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