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https://www.readbyqxmd.com/read/28934769/assessment-and-modelling-of-general-practice-and-community-setting-capacity-for-medical-trainees-in-northern-new-zealand
#1
Felicity Goodyear-Smith, Abbas Al-Murrani
AIMS: To estimate the capacity of general practice to accommodate undergraduate and postgraduate medical trainees, and model efficient ways to utilise identified capacity and increase capacity. METHODS: We conducted an online survey, with phone follow-up to non-responders, of all general practices in the northern half of New Zealand. The main outcome measures were current placements and future intentions for taking medical trainees; factors influencing decisions and possible incentives to take trainees...
September 22, 2017: New Zealand Medical Journal
https://www.readbyqxmd.com/read/28934764/assessment-of-training-capacity-in-new-zealand-general-practices-a-stocktake-in-the-lower-north-island-and-south-island
#2
Samantha A Murton, Susan Rh Pullon
AIM: General practices are providing clinically-based training for rapidly increasing numbers of medical (and other health professional) trainees. This study investigated capacity and intention of general practices to additionally teach junior doctors (now required to undertake community-based attachments by the New Zealand Medical Council) alongside current trainees in their service. METHODS: A web-based/telephone survey of all general practices was developed and administered November 2015-April 2016...
September 22, 2017: New Zealand Medical Journal
https://www.readbyqxmd.com/read/28934232/economic-costs-and-health-related-quality-of-life-for-hand-foot-and-mouth-disease-hfmd-patients-in-china
#3
Yaming Zheng, Mark Jit, Joseph T Wu, Juan Yang, Kathy Leung, Qiaohong Liao, Hongjie Yu
BACKGROUND: Hand, foot and mouth disease (HFMD) is a common illness in China that mainly affects infants and children. The objective of this study is to assess the economic cost and health-related quality of life associated with HFMD in China. METHOD: A telephone survey of caregivers were conducted in 31 provinces across China. Caregivers of laboratory-confirmed HFMD patients who were registered in the national HFMD enhanced surveillance database during 2012-2013 were invited to participate in the survey...
2017: PloS One
https://www.readbyqxmd.com/read/28934064/demographics-the-third-age-and-partial-retirement-policy-proposals-to-accommodate-the-changing-picture-of-female-retirement-in-canada
#4
Rosemary A Venne, Maureen Hannay
Much concern has been raised around the potential impact of the retirement of the large baby boom generation. This article specifically addresses the unique issues surrounding the retirement of female baby boomers. Demographic changes, including increased labor force participation, coupled with declining fertility rates, have resulted in a social transformation of the roles women play in society. Despite these changes, women still bear much of the caregiving responsibilities in the household, which can complicate retirement choices...
September 21, 2017: Journal of Women & Aging
https://www.readbyqxmd.com/read/28934002/estimating-the-optimal-personalized-treatment-strategy-based-on-selected-variables-to-prolong-survival-via-random-survival-forest-with-weighted-bootstrap
#5
Jincheng Shen, Lu Wang, Stephanie Daignault, Daniel E Spratt, Todd M Morgan, Jeremy M G Taylor
A personalized treatment policy requires defining the optimal treatment for each patient based on their clinical and other characteristics. Here we consider a commonly encountered situation in practice, when analyzing data from observational cohorts, that there are auxiliary variables which affect both the treatment and the outcome, yet these variables are not of primary interest to be included in a generalizable treatment strategy. Furthermore, there is not enough prior knowledge of the effect of the treatments or of the importance of the covariates for us to explicitly specify the dependency between the outcome and different covariates, thus we choose a model that is flexible enough to accommodate the possibly complex association of the outcome on the covariates...
September 21, 2017: Journal of Biopharmaceutical Statistics
https://www.readbyqxmd.com/read/28933538/bulky-%C3%AE-diketones-enabling-new-lewis-acidic-ligand-platforms
#6
Eser S Akturk, Steven J Scappaticci, Rachel N Seals, Michael P Marshak
The synthesis of a sterically encumbered β-diketone ligand ((Ar)acac) substituted with 2,6-(2,4,6-Me3C6H2)2C6H3 is described. Coordination complexes of the type M((Ar)acac)2Cl(solv) (M = Ti, V, Cr; solv = THF, CH3CN) were prepared by the reaction of (Ar)acac with MCl3 (M = V, Cr) or with TiCl4 to generate Ti((Ar)acac)2Cl2, followed by reduction. These complexes show a trend of alternating the cis/trans geometric preference with increasing d(n) electron count (n = 0, 1, 2, 3), which is rationalized in part by the unusual ability of β-diketonates to behave as either a weak π donor or a π acceptor in the cis and trans geometries, respectively...
September 21, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28931924/chimeric-14-3-3-proteins-for-unraveling-interactions-with-intrinsically-disordered-partners
#7
Nikolai N Sluchanko, Kristina V Tugaeva, Sandra J Greive, Alfred A Antson
In eukaryotes, several "hub" proteins integrate signals from different interacting partners that bind through intrinsically disordered regions. The 14-3-3 protein hub, which plays wide-ranging roles in cellular processes, has been linked to numerous human disorders and is a promising target for therapeutic intervention. Partner proteins usually bind via insertion of a phosphopeptide into an amphipathic groove of 14-3-3. Structural plasticity in the groove generates promiscuity allowing accommodation of hundreds of different partners...
September 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28931899/energetics-and-mechanism-of-anion-permeation-across-formate-nitrite-transporters
#8
Kalina Atkovska, Jochen S Hub
Formate-nitrite transporters (FNTs) facilitate the translocation of monovalent polyatomic anions, such as formate and nitrite, across biological membranes. FNTs are widely distributed among pathogenic bacteria and eukaryotic parasites, but they lack human homologues, making them attractive drug targets. The mechanisms and energetics involved in anion permeation across the FNTs have remained largely unclear. Both, channel and transporter mode of function have been proposed, with strong indication of proton coupling to the permeation process...
September 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28931613/interacting-networks-of-brain-regions-underlie-human-spatial-navigation-a-review-and-novel-synthesis-of-the-literature
#9
Arne D Ekstrom, Derek J Huffman, Michael Starrett
Navigation is an inherently dynamic and multimodal process, making isolation of the unique cognitive components underlying it challenging. The assumptions of much of the literature on human spatial navigation are that: 1) spatial navigation involves modality independent, discrete metric representations (i.e., egocentric vs. allocentric) 2) such representations can be further distilled to elemental cognitive processes 3) these cognitive processes can be ascribed to unique brain regions. Here, we argue that modality independent spatial representations, instead of providing exact metrics about our surrounding environment, more often involve heuristics for estimating spatial topology useful to the current task at hand...
September 20, 2017: Journal of Neurophysiology
https://www.readbyqxmd.com/read/28931434/long-term-outcome-of-autistic-spectrum-disorder-a-retrospective-case-study-in-a-southern-italian-region
#10
Francesca Felicia Operto, Federica Martino, Annalisa Rinaldi, Angelo Cerracchio, Giovanni Salvati, Mariano Orza, Claudia Lembo, Gianvito Panzarino, Claudia Di Paolantonio, Alberto Verrotti, Giovanni Farello, Giangennaro Coppola
BACKGROUND: Autism Spectrum Disorder (ASD) is a complex neurodevelopmental disorder, characterized by impaired social communication and restricted and repetitive behaviours, as well as associated features including intellectual disability and impaired sensorimotor function. Despite a growing interest in this devastating disorder for families and young parents, there are no certainties as regards its aetiology, although a significant genetic background is considered to be important. Since there is little information about the social adaptation and quality of life of patients with Autism Spectrum Disorder, we decided to study and evaluate the long-term outcome and quality of life in a sample of children, adolescent and young adults...
September 20, 2017: Italian Journal of Pediatrics
https://www.readbyqxmd.com/read/28931020/a-new-species-of-hermit-crab-diogenes-heteropsammicola-crustacea-decapoda-anomura-diogenidae-replaces-a-mutualistic-sipunculan-in-a-walking-coral-symbiosis
#11
Momoko Igawa, Makoto Kato
Symbiont shift is rare in obligate mutualisms because both the partners are reciprocally dependent on and specialized to each other. In the obligate accommodation-transportation mutualism between walking corals and sipunculans, however, an unusual saltatory symbiont shift was discovered. In shallow waters of southern Japan, an undescribed hermit crab species was found living in corallums of solitary scleractinian corals of the genera Heterocyathus and Heteropsammia, replacing the usual sipunculan symbiont. We described the hermit crab as a new species Diogenes heteropsammicola (Decapoda, Anomura, Diogenidae), and explored its association with the walking corals...
2017: PloS One
https://www.readbyqxmd.com/read/28929501/accommodating-the-ecological-fallacy-in-disease-mapping-in-the-absence-of-individual-exposures
#12
Feifei Wang, Jian Wang, Alan Gelfand, Fan Li
In health exposure modeling, in particular, disease mapping, the ecological fallacy arises because the relationship between aggregated disease incidence on areal units and average exposure on those units differs from the relationship between the event of individual incidence and the associated individual exposure. This article presents a novel modeling approach to address the ecological fallacy in the least informative data setting. We assume the known population at risk with an observed incidence for a collection of areal units and, separately, environmental exposure recorded during the period of incidence at a collection of monitoring stations...
September 19, 2017: Statistics in Medicine
https://www.readbyqxmd.com/read/28929348/-comparative-analysis-of-light-sensitivity-depth-and-motion-perception-in-animals-and-humans
#13
REVIEW
F Schaeffel
BACKGROUND: This study examined how humans perform regarding light sensitivity, depth perception and motion vision in comparison to various animals. OBJECTIVE: The parameters that limit the performance of the visual system for these different functions were examined. METHODS: This study was based on literature studies (search in PubMed) and own results. RESULTS: Light sensitivity is limited by the brightness of the retinal image, which in turn is determined by the f‑number of the eye...
September 19, 2017: Der Ophthalmologe: Zeitschrift der Deutschen Ophthalmologischen Gesellschaft
https://www.readbyqxmd.com/read/28928641/comparison-of-navigation-related-brain-regions-in-migratory-versus-non-migratory-noctuid-moths
#14
Liv de Vries, Keram Pfeiffer, Björn Trebels, Andrea K Adden, Ken Green, Eric Warrant, Stanley Heinze
Brain structure and function are tightly correlated across all animals. While these relations are ultimately manifestations of differently wired neurons, many changes in neural circuit architecture lead to larger-scale alterations visible already at the level of brain regions. Locating such differences has served as a beacon for identifying brain areas that are strongly associated with the ecological needs of a species-thus guiding the way towards more detailed investigations of how brains underlie species-specific behaviors...
2017: Frontiers in Behavioral Neuroscience
https://www.readbyqxmd.com/read/28928132/seca-mediates-cotranslational-targeting-and-translocation-of-an-inner-membrane-protein
#15
Shuai Wang, Chien-I Yang, Shu-Ou Shan
Protein targeting to the bacterial plasma membrane was generally thought to occur via two major pathways: cotranslational targeting by signal recognition particle (SRP) and posttranslational targeting by SecA and SecB. Recently, SecA was found to also bind ribosomes near the nascent polypeptide exit tunnel, but the function of this SecA-ribosome contact remains unclear. In this study, we show that SecA cotranslationally recognizes the nascent chain of an inner membrane protein, RodZ, with high affinity and specificity...
September 19, 2017: Journal of Cell Biology
https://www.readbyqxmd.com/read/28927267/atomistic-origins-of-high-capacity-and-high-structural-stability-of-polymer-derived-sioc-anode-materials
#16
Hong Sun, Kejie Zhao
Capacity and structural stability are often mutually exclusive properties of electrodes in Li-ion batteries: A gain in capacity is usually accompanied by the undesired large volumetric change of the host material upon lithiation. Polymer-derived ceramics, such as silicon oxycarbide (SiOC) of hybrid Si-O-C bonds, show an exceptional combination of high capacity and superior structural stability. We investigate the atomistic origins of the unique chemomechanical performance of carbon-rich SiOC using the first-principles theoretical approach...
September 20, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28925530/the-role-of-a-cytoplasmic-loop-of-mota-in-load-dependent-assembly-and-disassembly-dynamics-of-the-mota-b-stator-complex-in-the-bacterial-flagellar-motor
#17
Seyedeh Noorolhoda Shajari Pourjaberi, Naoya Terahara, Keiichi Namba, Tohru Minamino
The proton-driven flagellar motor of Salmonella enterica can accommodate a dozen MotA/B stators in a load-dependent manner. The C-terminal periplasmic domain of MotB acts as a structural switch to regulate the number of active stators in the motor in response to load change. The cytoplasmic loop termed MotAC is responsible for the interaction with a rotor protein, FliG. Here, to test if MotAC is responsble for stator assembly around the rotor in a load-dependent manner, we analyzed the effect of MotAC mutations, M76V, L78W, Y83C, Y83H, I126F, R131L, A145E and E155K, on motor performance over a wide range of external load...
September 19, 2017: Molecular Microbiology
https://www.readbyqxmd.com/read/28924919/use-of-accessible-examination-tables-in-the-primary-care-setting-a-survey-of-physical-evaluations-and-patient-attitudes
#18
Megan A Morris, Allysha C Maragh-Bass, Joan M Griffin, Lila J Finney Rutten, Tara Lagu, Sean Phelan
BACKGROUND: Accessible diagnostic equipment, including height-adjustable examination tables, is necessary to accommodate patients with disabilities. Studies demonstrate that only a minority of clinics provide accessible equipment. For clinics with this equipment, no studies have examined the use of such equipment in routine clinical care. OBJECTIVE: In primary care clinics with and without height-adjustable examination tables, we compared the frequency and variation in physical evaluations on examination tables and patients' perceptions of quality care...
September 18, 2017: Journal of General Internal Medicine
https://www.readbyqxmd.com/read/28924660/four-channel-super-resolution-imaging-by-3-d-structured-illumination
#19
Ulrike Engel
Multichannel imaging is used as a readout of relative localization of two or more components and is often the first step in investigating functional ensembles in cells. However, the localization volume of diffraction-limited light microscopy (approx. 200 nm by 500 nm) can accommodate hundred of proteins, calling for increased resolution for these types of analyses. Here, we present a protocol for 4-channel imaging using structured illumination microscopy (SIM), which increases resolution by a factor of two...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28924215/bilingual-cortical-control-of-between-and-within-language-competition
#20
Viorica Marian, James Bartolotti, Sirada Rochanavibhata, Kailyn Bradley, Arturo E Hernandez
The human capacity to master multiple languages is remarkable and leads to structural and functional changes in the brain. Understanding how the brain accommodates multiple languages simultaneously is crucial to developing a complete picture of our species' linguistic capabilities. To examine the neural mechanisms involved in processing two languages, we looked at cortical activation in Spanish-English bilinguals in response to phonological competition either between two languages or within a language. Participants recognized spoken words in a visual world task while their brains were scanned using functional magnetic resonance imaging (fMRI)...
September 18, 2017: Scientific Reports
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