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https://www.readbyqxmd.com/read/27933427/minimal-impact-of-response-shift-for-sf-12-mental-and-physical-health-status-in-homeless-and-vulnerably-housed-individuals-an-item-level-multi-group-analysis
#1
Anne M Gadermann, Richard Sawatzky, Anita Palepu, Anita M Hubley, Bruno D Zumbo, Tim Aubry, Susan Farrell, Stephen W Hwang
PURPOSE: The purpose of this study was to examine whether homeless or vulnerably housed individuals experienced response shift over a 12-month time period in their self-reported physical and mental health status. METHODS: Data were obtained from the Health and Housing in Transition study, a longitudinal multi-site cohort study in Canada (N = 1190 at baseline). Multi-group confirmatory factor analysis (MG-CFA) and methods for response shift detection at the item level, based on the approach by Oort, were used to test for reconceptualization, reprioritization, and recalibration response shift on the SF-12 in four groups of individuals who were homeless (n = 170), housed (n = 437), or who reported a change in their housing status [from homeless to housed (n = 285) or housed to homeless (n = 73)] over a 12-month time period...
December 8, 2016: Quality of Life Research
https://www.readbyqxmd.com/read/27933024/confabulating-misremembering-relearning-the-simulation-theory-of-memory-and-unsuccessful-remembering
#2
Kourken Michaelian
This article develops a taxonomy of memory errors in terms of three conditions: the accuracy of the memory representation, the reliability of the memory process, and the internality (with respect to the remembering subject) of that process. Unlike previous taxonomies, which appeal to retention of information rather than reliability or internality, this taxonomy can accommodate not only misremembering (e.g., the DRM effect), falsidical confabulation, and veridical relearning but also veridical confabulation and falsidical relearning...
2016: Frontiers in Psychology
https://www.readbyqxmd.com/read/27932950/amyloid-precursor-proteins-are-dynamically-trafficked-and-processed-during-neuronal-development
#3
Jenna M Ramaker, Robert S Cargill, Tracy L Swanson, Hanil Quirindongo, Marlène Cassar, Doris Kretzschmar, Philip F Copenhaver
Proteolytic processing of the Amyloid Precursor Protein (APP) produces beta-amyloid (Aβ) peptide fragments that accumulate in Alzheimer's Disease (AD), but APP may also regulate multiple aspects of neuronal development, albeit via mechanisms that are not well understood. APP is a member of a family of transmembrane glycoproteins expressed by all higher organisms, including two mammalian orthologs (APLP1 and APLP2) that have complicated investigations into the specific activities of APP. By comparison, insects express only a single APP-related protein (APP-Like, or APPL) that contains the same protein interaction domains identified in APP...
2016: Frontiers in Molecular Neuroscience
https://www.readbyqxmd.com/read/27931187/computational-strategies-for-alternative-single-step-bayesian-regression-models-with-large-numbers-of-genotyped-and-non-genotyped-animals
#4
Rohan L Fernando, Hao Cheng, Bruce L Golden, Dorian J Garrick
BACKGROUND: Two types of models have been used for single-step genomic prediction and genome-wide association studies that include phenotypes from both genotyped animals and their non-genotyped relatives. The two types are breeding value models (BVM) that fit breeding values explicitly and marker effects models (MEM) that express the breeding values in terms of the effects of observed or imputed genotypes. MEM can accommodate a wider class of analyses, including variable selection or mixture model analyses...
December 8, 2016: Genetics, Selection, Evolution: GSE
https://www.readbyqxmd.com/read/27931075/assessing-quantile-prediction-with-censored-quantile-regression-models
#5
Ruosha Li, Limin Peng
An important goal of censored quantile regression is to provide reliable predictions of survival quantiles, which are often reported in practice to offer robust and comprehensive biomedical summaries. However, formal methods for evaluating and comparing working quantile regression models in terms of their performance in predicting survival quantiles have been lacking, especially when the working models are subject to model mis-specification. In this article, we proposes a sensible and rigorous framework to fill in this gap...
December 8, 2016: Biometrics
https://www.readbyqxmd.com/read/27930698/major-depression-as-a-complex-dynamic-system
#6
Angélique O J Cramer, Claudia D van Borkulo, Erik J Giltay, Han L J van der Maas, Kenneth S Kendler, Marten Scheffer, Denny Borsboom
In this paper, we characterize major depression (MD) as a complex dynamic system in which symptoms (e.g., insomnia and fatigue) are directly connected to one another in a network structure. We hypothesize that individuals can be characterized by their own network with unique architecture and resulting dynamics. With respect to architecture, we show that individuals vulnerable to developing MD are those with strong connections between symptoms: e.g., only one night of poor sleep suffices to make a particular person feel tired...
2016: PloS One
https://www.readbyqxmd.com/read/27930670/ku-binding-on-telomeres-occurs-at-sites-distal-from-the-physical-chromosome-ends
#7
Mélanie V Larcher, Emeline Pasquier, R Stephen MacDonald, Raymund J Wellinger
The Ku complex binds non-specifically to DNA breaks and ensures repair via NHEJ. However, Ku is also known to bind directly to telomeric DNA ends and its presence there is associated with telomere capping, but avoiding NHEJ. How the complex discriminates between a DNA break and a telomeric extremity remains unknown. Our results using a tagged Ku complex, or a chromosome end capturing method, in budding yeast show that yKu association with telomeres can occur at sites distant from the physical end, on sub-telomeric elements, as well as on interstitial telomeric repeats...
December 2016: PLoS Genetics
https://www.readbyqxmd.com/read/27929718/lotus-japonicus-nf-ya1-plays-an-essential-role-during-nodule-differentiation-and-targets-members-of-the-shi-sty-gene-family
#8
Md Shakhawat Hossain, Arina Shrestha, Sihui Zhong, Mandana Miri, Ryan S Austin, Shusei Sato, Loretta Ross, Terry Huebert, Alexandre Tromas, Ivone Torres-Jerez, Yuhong Tang, Michael Udvardi, Jeremy Dale Murray, Krzysztof Szczyglowski
Legume plants engage in intimate relationships with rhizobial bacteria to form nitrogen-fixing nodules, root-derived organs that accommodate the micro-symbiont. Members of the Nuclear Factor Y (NF-Y) gene family, which have undergone significant expansion and functional diversification during plant evolution, are essential for this symbiotic liaison. Acting in a partially redundant manner, NF-Ys were shown previously to regulate bacterial infection, including selection of a superior rhizobial strain, and to mediate nodule structure formation...
December 8, 2016: Molecular Plant-microbe Interactions: MPMI
https://www.readbyqxmd.com/read/27929491/validation-of-an-improved-helical-diode-array-and-dose-reconstruction-software-using-tg-244-datasets-and-stringent-dose-comparison-criteria
#9
Saeed Ahmed, Benjamin Nelms, Jakub Kozelka, Geoffrey Zhang, Eduardo Moros, Vladimir Feygelman
The original helical ArcCHECK (AC) diode array and associated software for 3D measurement-guided dose reconstruction were characterized and validated; however, recent design changes to the AC required that the subject be revisited. The most important AC change starting in 2014 was a significant reduction in the overresponse of diodes to scattered radiation outside of the direct beam, accom-plished by reducing the amount of high-Z materials adjacent to the diodes. This change improved the diode measurement accuracy, but in the process invalidated the dose reconstruction models that were assembled based on measured data acquired with the older version of the AC...
November 8, 2016: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/27929456/high-throughput-detection-of-respiratory-pathogens-in-animal-specimens-by-nanoscale-pcr
#10
Laura B Goodman, Renee R Anderson, Marcia Slater, Elen Ortenberg, Randall W Renshaw, Brittany D Chilson, Melissa A Laverack, John S Beeby, Edward J Dubovi, Amy L Glaser
Nanoliter scale real-time PCR uses spatial multiplexing to allow multiple assays to be run in parallel on a single plate without the typical drawbacks of combining reactions together. We designed and evaluated a panel based on this principle to rapidly identify the presence of common disease agents in dogs and horses with acute respiratory illness. This manuscript describes a nanoscale diagnostic PCR workflow for sample preparation, amplification, and analysis of target pathogen sequences, focusing on procedures that are different from microliter scale reactions...
November 28, 2016: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/27929153/local-environment-inside-a-novel-aromatic-micelle-investigated-by-steady-state-and-femtosecond-fluorescence-spectroscopy-of-an-encapsulated-solvatochromic-probe
#11
Matthew M Sartin, Kei Kondo, Michito Yoshizawa, Satoshi Takeuchi, Tahei Tahara
The local environment within a recently developed anthracene-shelled micelle (ASM), which is a micelle-like nanocapsule composed of anthracene-embedded amphiphiles, was investigated by steady-state and time-resolved spectroscopy of an encapsulated solvatochromic fluorescent probe molecule, coumarin 153 (C153). The absorption maximum of encapsulated C153 (452 nm) is more red-shifted than that of free C153 in water, indicating a highly polar environment inside the micelle. Despite this, the fluorescence Stokes shift of encapsulated C153 (∼3700 cm(-1)) is substantially smaller than that of free C153 in water...
December 8, 2016: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/27928555/oxatub-5-6-arene-synthesis-conformational-analysis-and-the-recognition-of-c60-and-c70
#12
Fei Jia, Dong-Hao Li, Ti-Long Yang, Liu-Pan Yang, Li Dang, Wei Jiang
Large oxatub[n]arenes (n = 5, 6) have been synthesized and characterized. Their conformational complexity was analyzed and host-guest chemistry was studied. In particular, the rather flexible oxatub[6]arene is able to accommodate C60 and C70 with moderate binding affinities. Computational results suggest that there are different binding affinities to C60 or C70 for each conformer of oxatub[6]arene. This endows oxatub[6]arene with conformational adaptability according to the needs of its guests.
December 8, 2016: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/27927902/challenges-in-species-tree-estimation-under-the-multispecies-coalescent-model
#13
REVIEW
Bo Xu, Ziheng Yang
The multispecies coalescent (MSC) model has emerged as a powerful framework for inferring species phylogenies while accounting for ancestral polymorphism and gene tree-species tree conflict. A number of methods have been developed in the past few years to estimate the species tree under the MSC. The full likelihood methods (including maximum likelihood and Bayesian inference) average over the unknown gene trees and accommodate their uncertainties properly but involve intensive computation. The approximate or summary coalescent methods are computationally fast and are applicable to genomic datasets with thousands of loci, but do not make an efficient use of information in the multilocus data...
December 2016: Genetics
https://www.readbyqxmd.com/read/27927025/-whenever-i-can-i-push-myself-to-go-to-work-a-qualitative-study-of-experiences-of-sickness-presenteeism-among-workers-with-rheumatoid-arthritis
#14
Paula Holland, Alison M Collins
PURPOSE: UK government policy emphasizes the importance of continuing to work for recovery from poor health, yet sickness presenteeism (going to work whilst ill) is commonly regarded as having negative consequences for organizations and individuals. Our study explores experiences of working after onset of rheumatoid arthritis (RA), a chronic musculoskeletal disorder characterized by high rates of work disability. MATERIALS AND METHODS: An exploratory qualitative study consisting of in-depth interviews and six-month follow-up with 11 men and women with RA employed at disease onset...
December 8, 2016: Disability and Rehabilitation
https://www.readbyqxmd.com/read/27925559/students-under-pressure
#15
Ali Horner
I trained at a school of nursing, received a small but adequate salary each month, and had accommodation and transport for early and late shifts provided for me.
December 7, 2016: Nursing Standard
https://www.readbyqxmd.com/read/27925095/peritoneal-dialysis-family-care-for-chronic-kidney-disease-patients-in-home-based-treatment
#16
Joyce Martins Arimatea Branco Tavares, Marcia Tereza Luz Lisboa, Márcia de Assunção Ferreira, Glaucia Valente Valadares, Frances Valéria Costa E Silva
Objective: to propose a family care model for patients with chronic kidney disease in peritoneal dialysis based on evidence indicated by family members. Method: this was a qualitative descriptive study that used the Convergent Care Research method. It was conducted at a state hospital in Rio de Janeiro, including techniques for recording individual interviews and consisted of a group of 19 study participants. Data were analyzed according to the stages proposed by the method, generating a category that used a cultural question as the basis for patient care resulting in a proposal for home-based family care...
November 2016: Revista Brasileira de Enfermagem
https://www.readbyqxmd.com/read/27924818/an-ultra-tunable-platform-for-molecular-engineering-of-high-performance-crystalline-porous-materials
#17
Quan-Guo Zhai, Xianhui Bu, Chengyu Mao, Xiang Zhao, Luke Daemen, Yongqiang Cheng, Anibal J Ramirez-Cuesta, Pingyun Feng
Metal-organic frameworks are a class of crystalline porous materials with potential applications in catalysis, gas separation and storage, and so on. Of great importance is the development of innovative synthetic strategies to optimize porosity, composition and functionality to target specific applications. Here we show a platform for the development of metal-organic materials and control of their gas sorption properties. This platform can accommodate a large variety of organic ligands and homo- or hetero-metallic clusters, which allows for extraordinary tunability in gas sorption properties...
December 7, 2016: Nature Communications
https://www.readbyqxmd.com/read/27924347/preprocessing-structured-clinical-data-for-predictive-modeling-and-decision-support-a-roadmap-to-tackle-the-challenges
#18
José Carlos Ferrão, Mónica Duarte Oliveira, Filipe Janela, Henrique M G Martins
BACKGROUND: EHR systems have high potential to improve healthcare delivery and management. Although structured EHR data generates information in machine-readable formats, their use for decision support still poses technical challenges for researchers due to the need to preprocess and convert data into a matrix format. During our research, we observed that clinical informatics literature does not provide guidance for researchers on how to build this matrix while avoiding potential pitfalls...
December 7, 2016: Applied Clinical Informatics
https://www.readbyqxmd.com/read/27924186/treatment-of-chronic-hepatitis-c-infection-with-sofosbuvir-based-regimens-in-a-commercially-insured-patient-population
#19
John Barron, Yiqiong Xie, Sze-Jung Wu, Jeff White, Joseph Singer, Bernard Tulsi, Alan Rosenberg
BACKGROUND: The response to treatment with direct-acting antiviral agents in patients with chronic hepatitis C virus (HCV) is not well-characterized in the real-world setting. OBJECTIVE: To describe patients' response to 3 sofosbuvir-based treatment regimens among commercially insured patients with chronic HCV. METHODS: In this observational study, we identified patients with HCV who started sofosbuvir treatment with 1 of 3 sofosbuvir-based regimens between December 1, 2013, and April 30, 2014, in the HealthCore Integrated Research Database, a large managed care repository...
September 2016: American Health & Drug Benefits
https://www.readbyqxmd.com/read/27923923/antiviral-innate-immune-response-interferes-with-the-formation-of-replication-associated-membrane-structures-induced-by-a-positive-strand-rna-virus
#20
Diede Oudshoorn, Barbara van der Hoeven, Ronald W A L Limpens, Corrine Beugeling, Eric J Snijder, Montserrat Bárcena, Marjolein Kikkert
: Infection with nidoviruses like corona- and arteriviruses induces a reticulovesicular network of interconnected endoplasmic reticulum (ER)-derived double-membrane vesicles (DMVs) and other membrane structures. This network is thought to accommodate the viral replication machinery and protect it from innate immune detection. We hypothesized that the innate immune response has tools to counteract the formation of these virus-induced replication organelles in order to inhibit virus replication...
December 6, 2016: MBio
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