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https://www.readbyqxmd.com/read/29333691/the-innate-immune-system-in-chronic-cardiomyopathy-a-european-society-of-cardiology-esc-scientific-statement-from-the-working-group-on-myocardial-function-of-the-esc
#1
REVIEW
Stefan Frantz, Ines Falcao-Pires, Jean-Luc Balligand, Johann Bauersachs, Dirk Brutsaert, Michele Ciccarelli, Dana Dawson, Leon J de Windt, Mauro Giacca, Nazha Hamdani, Denise Hilfiker-Kleiner, Emilio Hirsch, Adelino Leite-Moreira, Manuel Mayr, Thomas Thum, Carlo G Tocchetti, Jolanda van der Velden, Gilda Varricchi, Stephane Heymans
Activation of the immune system in heart failure (HF) has been recognized for over 20 years. Initially, experimental studies demonstrated a maladaptive role of the immune system. However, several phase III trials failed to show beneficial effects in HF with therapies directed against an immune activation. Preclinical studies today describe positive and negative effects of immune activation in HF. These different effects depend on timing and aetiology of HF. Therefore, herein we give a detailed review on immune mechanisms and their importance for the development of HF with a special focus on commonalities and differences between different forms of cardiomyopathies...
January 15, 2018: European Journal of Heart Failure
https://www.readbyqxmd.com/read/29330259/limited-accuracy-of-administrative-data-for-the-identification-and-classification-of-adult-congenital-heart-disease
#2
Abigail Khan, Katrina Ramsey, Cody Ballard, Emily Armstrong, Luke J Burchill, Victor Menashe, George Pantely, Craig S Broberg
BACKGROUND: Administrative data sets utilize billing codes for research and quality assessment. Previous data suggest that such codes can accurately identify adults with congenital heart disease (CHD) in the cardiology clinic, but their use has yet to be validated in a larger population. METHODS AND RESULTS: All administrative codes from an entire health system were queried for a single year. Adults with a CHD diagnosis code (International Classification of Diseases, Ninth Revision, (ICD-9) codes 745-747) defined the cohort...
January 12, 2018: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29329440/executive-function-and-internalizing-symptoms-in-adolescents-and-young-adults-with-congenital-heart-disease-the-role-of-coping
#3
Jamie L Jackson, Gina M Gerardo, Jennifer D Monti, Kyle A Schofield, Kathryn Vannatta
Executive functioning deficits have been documented among congenital heart disease (CHD) survivors and may contribute to emotional distress. Little research has investigated the role of coping in this association. This study examined the role of coping in accounting for the association between self-reported executive function problems and internalizing symptoms among adolescents and emerging adults (AEAs), as well as young adults (YAs) with CHD. Participants included 74 AEA ( M age  = 19.32  ±  3.47 years, range 15-25 years) and 98 YA CHD survivors ( M age  = 32...
January 10, 2018: Journal of Pediatric Psychology
https://www.readbyqxmd.com/read/29329115/developing-a-mitral-valve-center-of-excellence
#4
Ahmed El-Eshmawi, Javier G Castillo, Gilbert H L Tang, David H Adams
PURPOSE OF REVIEW: Despite the proven superiority of mitral repair over replacement for degenerative mitral disease, mitral valve replacement remains common. Guidelines now recommend referral of patients, particularly those whom are asymptomatic, to valve centers of excellence, although criteria that define such centers remain to be established. The purpose of this review is to define the structure of a mitral center of excellence and to review current clinical outcomes which are possible in such a center...
January 10, 2018: Current Opinion in Cardiology
https://www.readbyqxmd.com/read/29327527/role-and-relevance-of-blood-pressure-variability-in-hypertension-related-co-morbidities
#5
Ashok Kumar, B C Kalmath, Georgi Abraham, Johann Christopher, Pln Kaparthi, Louie Fischer, Neeta Deshpande, N K Mishra, Praveen Raj, Rajesh Javerani, Ramesh Goyal, Reefa Dsouza, Shashank R Joshi
Despite maintaining mean blood pressure at optimal levels, cardiovascular complications still occur in hypertensive patients. Blood pressure variability (BPV) has been implicated as a prominent factor responsible for incurring this additional risk. In this review we attempted to generate a consensus on the importance of BPV in the hypertension management and to evaluate different therapeutic options available to reduce BPV. Panel comprising of 11 leading experts from India in different areas of clinical practice (including nephrology, diabetes and endocrinology, cardiology, and critical care medicine) was convened...
December 2017: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/29322695/bioresorbable-scaffolds-in-coronary-intervention-unmet-needs-and-evolution
#6
REVIEW
Davide Capodanno
Bioresorbable scaffolds (BRS) represent a novel paradigm in the 40-year history of interventional cardiology. Restoration of cyclic pulsatility and physiologic vasomotion, adaptive vascular remodeling, plaque regression, and removal of the trigger for late adverse events are expected BRS benefits over current metallic drug-eluting stents. However, first-generation BRS devices have significant manufacturing limitations and rely on optimal implantation technique to avoid experiencing an excess of clinical events...
January 2018: Korean Circulation Journal
https://www.readbyqxmd.com/read/29321796/heart-rate-variability-a-new-tool-to-predict-complications-in-adult-cardiac-surgery
#7
Antonio Nenna, Mario Lusini, Cristiano Spadaccio, Francesco Nappi, Salvatore Matteo Greco, Raffaele Barbato, Elvio Covino, Massimo Chello
Heart rate variability (HRV) refers to the variations between consecutive heartbeats, which depend on the continuous modulation of the sympathetic and parasympathetic branches of the autonomic nervous system. HRV has been shown to be effective as a predictor of risk after myocardial infarction and an early warning sign of diabetic neuropathy, and in the cardiology setting is now recognized to be a useful tool for risk-stratification after hospital admission and after discharge. Recent evidences suggest that HRV analysis might predict complications even in patients undergoing cardiac surgery, and the present review summarizes the importance of HRV analysis in adult cardiac surgery and the perspectives for HRV use in current clinical practice...
November 2017: Journal of Geriatric Cardiology: JGC
https://www.readbyqxmd.com/read/29321066/perioperative-management-of-antiplatelet-therapy-in-patients-undergoing-non-cardiac-surgery-following-coronary-stent-placement-a-systematic-review
#8
Christopher P Childers, Melinda Maggard-Gibbons, Jesus G Ulloa, Ian T MacQueen, Isomi M Miake-Lye, Roberta Shanman, Selene Mak, Jessica M Beroes, Paul G Shekelle
BACKGROUND: The correct perioperative management of antiplatelet therapy (APT) in patients undergoing non-cardiac surgery (NCS) is often debated by clinicians. American College of Cardiology (ACC) and American Heart Association (AHA) guidelines recommend postponing elective NCS at least 3 months after stent implantation. Regardless of the timing of surgery, ACC/AHA guidelines recommend continuing at least ASA throughout the perioperative period and ideally continuing dual APT (DAPT) therapy "unless surgery demands discontinuation...
January 10, 2018: Systematic Reviews
https://www.readbyqxmd.com/read/29315727/considerations-for-optimal-blood-pressure-goals-in-the-elderly-population-a-review-of-emergent-evidence
#9
Diana X Cao, Rebecca J C Tran
Recent hypertension clinical trials and national guideline updates have created a debate on the most appropriate treatment goals in elderly patients with hypertension. In 2014, recommendations by the Eighth Joint National Committee (JNC 8) allowed a more lenient goal for patients 60 years and older compared with previous guidelines. Since then, several large clinical trials and meta-analyses have added more information regarding strict versus lenient treatment goals. Most recently, the American College of Cardiology and American Heart Association Task Force published their highly-anticipated hypertension guideline developed in conjunction with nine additional interdisciplinary organizations...
January 8, 2018: Pharmacotherapy
https://www.readbyqxmd.com/read/29310136/device-closure-versus-medical-therapy-alone-for-patent-foramen-ovale-in-patients-with-cryptogenic-stroke-a-systematic-review-and-meta-analysis
#10
Rahman Shah, Mannu Nayyar, Ion S Jovin, Abdul Rashid, Beatrix R Bondy, Tai-Hwang M Fan, Michael P Flaherty, Sunil V Rao
Background: The optimal strategy for preventing recurrent stroke in patients with cryptogenic stroke and patent foramen ovale (PFO) is unknown. Purpose: To compare transcatheter PFO closure with medical therapy alone for prevention of recurrent stroke in patients with PFO and cryptogenic stroke. Data Sources: PubMed and the Cochrane Library (without language restrictions) from inception to October 2017, reference lists, and abstracts from cardiology meetings...
January 9, 2018: Annals of Internal Medicine
https://www.readbyqxmd.com/read/29310133/percutaneous-closure-versus-medical-treatment-in-stroke-patients-with-patent-foramen-ovale-a-systematic-review-and-meta-analysis
#11
Salvatore De Rosa, Horst Sievert, Jolanda Sabatino, Alberto Polimeni, Sabato Sorrentino, Ciro Indolfi
Background: New evidence emerged recently regarding the percutaneous closure of patent foramen ovale (PFO) to prevent recurrent stroke in patients with cryptogenic stroke. Purpose: To compare risks for recurrent cerebrovascular events in adults with PFO and cryptogenic stroke who underwent PFO closure versus those who received medical therapy alone. Data Sources: PubMed, Scopus, and Google Scholar from 1 December 2004 through 14 September 2017; references of eligible studies; relevant scientific session abstracts; and cardiology Web sites...
January 9, 2018: Annals of Internal Medicine
https://www.readbyqxmd.com/read/29309572/cardiovascular-magnetic-resonance-imaging-in-hypertrophic-cardiomyopathy-the-importance-of-clinical-context
#12
Giovanni Quarta, Giovanni Donato Aquaro, Patrizia Pedrotti, Gianluca Pontone, Santo Dellegrottaglie, Attilio Iacovoni, Paolo Brambilla, Silvia Pradella, Giancarlo Todiere, Fausto Rigo, Chiara Bucciarelli-Ducci, Giuseppe Limongelli, Alberto Roghi, Iacopo Olivotto
In patients with suspected or established hypertrophic cardiomyopathy (HCM), cardiovascular magnetic resonance (CMR) is widely employed for clinical management, given its multimodality approach capable of providing unique information on cardiac morphology, function, and tissue characterization. Guidance regarding all aspects of HCM diagnosis and management is provided by the comprehensive 2014 European Society of Cardiology (ESC) guidelines on HCM. CMR should be performed in centres with recognized expertise in heart muscle diseases, by physicians who are familiar with the whole HCM disease spectrum, differential diagnoses, and pitfalls...
December 22, 2017: European Heart Journal Cardiovascular Imaging
https://www.readbyqxmd.com/read/29309567/current-and-future-cardiovascular-disease-risk-assessment-in-the-european-union-an-international-comparative-study
#13
Teresa J Mossakowska, Catherine L Saunders, Jennie Corbett, Calum MacLure, Eleanor M Winpenny, Elma Dujso, Rupert A Payne
Background: Risk assessment is central to primary prevention of cardiovascular disease (CVD), but there remains a need to better understand the use of evidence-based interventions in practice. This study examines: (i) the policies and guidelines for risk assessment in Europe, (ii) the use of risk assessment tools in clinical practice and (iii) the barriers to, and facilitators of, risk assessment. Methods: Data were collected from academics, clinicians and policymakers in an online questionnaire targeted at experts from all European Union member states, and in 8 in-depth country case studies that were developed from a targeted literature review and 36 interviews...
January 4, 2018: European Journal of Public Health
https://www.readbyqxmd.com/read/29305202/reducing-overutilization-of-preoperative-medical-referrals-among-patients-undergoing-radical-cystectomy-using-an-evidence-based-algorithm
#14
Nima Almassi, Michelle Ponziano, Howard B Goldman, Eric A Klein, Andrew J Stephenson, Venkatesh Krishnamurthi
OBJECTIVE: - To evaluate the frequency with which preoperative medical evaluations lead to changes in perioperative management of patients undergoing radical cystectomy and to examine the impact of an evidence-based algorithm on referral utilization. METHODS: - A retrospective review of 176 patients undergoing radical cystectomy in 2013-2014 was conducted. Patients referred for additional preoperative medical or cardiology evaluation were identified and the incidence of diagnostic testing or management changes resulting from such evaluations determined...
January 2, 2018: Urology
https://www.readbyqxmd.com/read/29302701/structure-and-function-of-the-nppa-nppb-cluster-locus-during-heart-development-and-disease
#15
REVIEW
Joyce Man, Phil Barnett, Vincent M Christoffels
Atrial natriuretic factor and brain natriuretic peptide are two important biomarkers in clinical cardiology. These two natriuretic peptide hormones are encoded by the paralogous genes Nppa and Nppb, which are evolutionary conserved. Both genes are predominantly expressed by the heart muscle during the embryonic and fetal stages, and in particular Nppa expression is strongly reduced in the ventricles after birth. Upon cardiac stress, Nppa and Nppb are strongly upregulated in the ventricular myocardium. Much is known about the molecular and physiological ques inducing Nppa and Nppb expression; however, the transcriptional regulatory mechanisms of the Nppa-Nppb cluster in vivo has proven to be quite complex and is not well understood...
January 4, 2018: Cellular and Molecular Life Sciences: CMLS
https://www.readbyqxmd.com/read/29287944/prediction-of-early-adverse-events-in-emergency-department-patients-with-acute-heart-failure-a-systematic-review
#16
REVIEW
Allison M Michaud, Shannon I A Parker, Heather Ganshorn, Justin A Ezekowitz, Andrew D McRae
BACKGROUND: Acute heart failure (AHF) accounts for a substantial proportion of Emergency Department (ED) visits and hospitalizations. Previous studies have shown that emergency physicians' clinical gestalt is not sufficient to stratify patients with AHF into severe and requiring hospitalization vs nonsevere and safe to be discharged. Various prognostic algorithms have been developed to risk-stratify patients with AHF, however there is no consensus as to the best-performing risk assessment tool in the ED...
September 12, 2017: Canadian Journal of Cardiology
https://www.readbyqxmd.com/read/29287140/introduction-from-fetal-echocardiography-to-fetal-cardiology-a-journey-of-over-half-a-century
#17
Shuping Ge, Dev Maulik
In this Special Issue of the Journal, 8 review articles that represent the new developments and applications of fetal echocardiography and fetal cardiology for diagnosis, prognosis, and treatment of fetal cardiovascular disease are included. The goal was to provide an updated review of the evidence for the current and emerging use of fetal echocardiography and cardiac magnetic resonance, improved diagnosis of challenging congenital heart disease, new tools for evaluation of fetal systolic and diastolic function, better prognosis and risk stratification of newborns with congenital heart diseases, and new and promising therapies for fetuses with cardiovascular disease...
December 2017: Echocardiography
https://www.readbyqxmd.com/read/29286280/the-2017-seventh-world-congress-of-pediatric-cardiology-cardiac-surgery-week-in-review-electrophysiology
#18
Mitchell I Cohen, Susan Etheridge, Shubhayan Sanatani, Alpay Celiker
No abstract text is available yet for this article.
December 2017: Cardiology in the Young
https://www.readbyqxmd.com/read/29286277/nomenclature-for-congenital-and-paediatric-cardiac-disease-the-international-paediatric-and-congenital-cardiac-code-ipccc-and-the-eleventh-iteration-of-the-international-classification-of-diseases-icd-11
#19
Rodney C G Franklin, Marie J Béland, Steven D Colan, Henry L Walters, Vera D Aiello, Robert H Anderson, Frédérique Bailliard, Jeffrey R Boris, Meryl S Cohen, J William Gaynor, Kristine J Guleserian, Lucile Houyel, Marshall L Jacobs, Amy L Juraszek, Otto N Krogmann, Hiromi Kurosawa, Leo Lopez, Bohdan J Maruszewski, James D St Louis, Stephen P Seslar, Shubhika Srivastava, Giovanni Stellin, Christo I Tchervenkov, Paul M Weinberg, Jeffrey P Jacobs
An internationally approved and globally used classification scheme for the diagnosis of CHD has long been sought. The International Paediatric and Congenital Cardiac Code (IPCCC), which was produced and has been maintained by the International Society for Nomenclature of Paediatric and Congenital Heart Disease (the International Nomenclature Society), is used widely, but has spawned many "short list" versions that differ in content depending on the user. Thus, efforts to have a uniform identification of patients with CHD using a single up-to-date and coordinated nomenclature system continue to be thwarted, even if a common nomenclature has been used as a basis for composing various "short lists"...
December 2017: Cardiology in the Young
https://www.readbyqxmd.com/read/29286276/the-2017-seventh-world-congress-of-pediatric-cardiology-cardiac-surgery-week-in-review-cardiac-surgery
#20
Tom R Karl
The 2017 Seventh World Congress was held in Barcelona, Spain, 16-21 July. The week in review for this meeting is presented in the current issue of Cardiology in the Young, and herein we discuss the surgical highlights of the programme.
December 2017: Cardiology in the Young
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