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TK Management

Luciano Bissolotti, Pedro Berjano, Paola Zuccher, Andrea Zenorini, Riccardo Buraschi, Jorge Hugo Villafañe, Stefano Negrini
PURPOSE: The aim of this study was to describe the disease-related sagittal balance changes in relation to the sacro-pelvic morphology of Parkinson's Disease patients with different duration of disease. METHODS: One hundred and seventy-five consecutive Parkinson's Disease (PD) patients (102 males, 73 females; age: 55-83 years) participated in the cross-sectional study. The clinical assessment included: Hoehn Yahr (H&Y) score; Tinetti score; plumb line (PL) distance from the spinous process of C7, L3 and S1 and kyphosis apex...
April 1, 2017: European Spine Journal
Chrystal S Mantyka-Pringle, Timothy D Jardine, Lori Bradford, Lalita Bharadwaj, Andrew P Kythreotis, Jennifer Fresque-Baxter, Erin Kelly, Gila Somers, Lorne E Doig, Paul D Jones, Karl-Erich Lindenschmidt
Cumulative environmental impacts driven by anthropogenic stressors lead to disproportionate effects on indigenous communities that are reliant on land and water resources. Understanding and counteracting these effects requires knowledge from multiple sources. Yet the combined use of Traditional Knowledge (TK) and Scientific Knowledge (SK) has both technical and philosophical hurdles to overcome, and suffers from inherently imbalanced power dynamics that can disfavour the very communities it intends to benefit...
February 26, 2017: Environment International
Wei-Yu Chen, Wen-Hsuan Li, Yun-Ru Ju, Chung-Min Liao, Vivian Hsiu-Chuan Liao
Cadmium (Cd) is of great concern in the soil environment and it can damage terrestrial organisms. The purpose of this study was to employ a toxicokinetic/toxicodynamic (TK/TD) approach to investigate the effects of toxicologically relevant Cd accumulation on the life cycle growth of earthworms (Lumbricus rubellus and Eisenia fetida) and to assess potential terrestrial ecosystem risk. We reanalyzed growth toxicity and whole body and pellet accumulation data linked with TK/TD and life cycle growth models to estimate key rate constants...
April 2017: Ecotoxicology
Hwee Weng Dennis Hey, Gordon Chengyuan Wong, Chloe Chan Xiaoyun, Leok-Lim Lau, Naresh Kumar, Joseph Shantakumar Thambiah, John Nathaniel Ruiz, Ka-Po Gabriel Liu, Hee-Kit Wong
BACKGROUND CONTEXT: Knowledge of sagittal radiographical parameters in AIS patients has not yet caught up with our understanding of their roles in patients with adult spinal deformity. It is likely that more emphasis will be placed in restoring sagittal parameters for AIS patients in the future. Therefore we need to understand how these parameters may vary in AIS to facilitate management plans. PURPOSE: To determine the reproducibility of sagittal spinal parameters on lateral film radiographs in patients with AIS...
January 5, 2017: Spine Journal: Official Journal of the North American Spine Society
Kateri Bertran, Dong-Hun Lee, Charles Balzli, Mary J Pantin-Jackwood, Erica Spackman, David E Swayne
In 2014-2015, the US experienced an unprecedented outbreak of H5 clade highly pathogenic avian influenza (HPAI) virus. The H5N2 HPAI virus outbreak in the Midwest in 2015 affected commercial turkey and layer farms, but not broiler farms. To assess any potential genetic resistance of broilers and/or age-related effects, we investigated the pathogenesis and transmission of A/turkey/Minnesota/12582/2015 (H5N2) (Tk/MN/15) virus in commercial 5-week-old broilers, 8-week-old broilers, and >30-week-old broiler breeders...
November 21, 2016: Veterinary Research
Talerngsak Kanjanabuch, Nuttha Lumlertgul, Lachlan J Pearson, Tanittha Chatsuwan, Krit Pongpirul, Asada Leelahavanichkul, Nisa Thongbor, Gunticha Nuntawong, Laksamon Praderm, Pantiwa Wechagama, Surapong Narenpitak, Apinya Wechpradit, Worauma Punya, Guttiga Halue, Phetpailin Naka, Somboon Jeenapongsa, Somchai Eiam-Ong
♦ Background: Melioidosis, an infectious disease caused by Burkholderia pseudomallei, is endemic in Southeast Asia and Northern Australia. Although a wide range of clinical manifestations from this organism are known, peritonitis associated with peritoneal dialysis (PD) has rarely been reported. ♦ Patients and Methods: Peritoneal dialysis patients from all regions in Thailand were eligible for the study if they had peritonitis and either peritoneal fluid or effluent culture positive for B.pseudomallei Patient data obtained included baseline characteristics, laboratory investigations, treatments, and clinical outcomes...
October 13, 2016: Peritoneal Dialysis International: Journal of the International Society for Peritoneal Dialysis
Yaoping Shi, Jianfeng Wang, Zhibin Bai, Yonggang Li, Longhua Qiu, Bo Zhai, Feng Zhang, Xiaoming Yang
Despite recent advances in surgical technique and treatment strategies for esophageal cancer (EC), to effectively manage the advanced (metastatic or disseminated) and recurrent EC still remain a great challenge. The aim of this study was to determine the feasibility of using intra-esophagus radiofrequency hyperthermia to enhance local HSV-TK/ganciclovir-mediated suicide gene therapy of an innovative animal models with orthotopic esophageal squamous cancers. Human esophageal squamous cancer (ESCa) cells were labeled with lentivirus/luciferase...
2016: American Journal of Cancer Research
E Lorge, M M Moore, J Clements, M O'Donovan, M D Fellows, M Honma, A Kohara, S Galloway, M J Armstrong, V Thybaud, B Gollapudi, M J Aardema, J Y Tanir
Good cell culture practice and characterization of the cell lines used are of critical importance in in vitro genotoxicity testing. The objective of this initiative was to make continuously available stocks of the characterized isolates of the most frequently used mammalian cell lines in genotoxicity testing anywhere in the world ('IVGT' cell lines). This project was organized under the auspices of the International Life Sciences Institute (ILSI) Health and Environmental Sciences Institute (HESI) Project Committee on the Relevance and Follow-up of Positive Results in In Vitro Genetic Toxicity (IVGT) Testing...
October 2016: Mutation Research
Jianfeng Wang, Yaoping Shi, Zhibin Bai, Yonggang Li, Longhua Qiu, Guy Johnson, Feng Zhang, Xiaoming Yang
PURPOSE: To determine the feasibility of using radiofrequency hyperthermia (RFH) to enhance the therapeutic effect of herpes simplex virus thymidine kinase/ganciclovir (HSV-TK/GCV) for the treatment of hepatocellular carcinoma (HCC). MATERIALS AND METHODS: Human HCC cells (HepG2) were first transfected with lentivirus/luciferase. For both in-vitro confirmation and in-vivo validation, luciferase-labeled HCC cells and HCC tumor xenografts on mice received different treatments: (i) combination therapy of intratumoral HSV-TK/GCV-mediated gene therapy plus MR imaging-heating-guidewire (MRIHG)-mediated RFH; (ii) gene therapy only; (iii) RFH only; and (iv) phosphate-buffered saline (PBS) as control...
August 28, 2016: International Journal of Hyperthermia
Jingfeng Luo, Xiaotian Wu, Fei Zhou, Yurong Zhou, Tongchun Huang, Fei Liu, Guocan Han, Luming Chen, Weixian Bai, Xia Wu, Jihong Sun, Xiaoming Yang
OBJECTIVE: Gene therapy is a frontier in modern medicine. In the present study, we explored a new technique for the effective treatment of multidrug-resistant (MDR) breast cancer by combining fully the advantages of multidisciplinary fields, including image-guided minimally invasive interventional oncology, radiofrequency technology, and direct intratumoral gene therapy. RESULTS: Combination treatment with PHSP-TK plus RFH resulted in significantly higher TK gene transfection/expression, as well as a lower cell proliferation rate and a higher cell apoptosis index, than those of control groups...
October 4, 2016: Oncotarget
Jianfeng Wang, Ang Li, Mei Jin, Fan Zhang, Xiaoling Li
Herpes simplex virus-thymidine kinase/ganciclovir (HSV-TK/GCV) therapy is one of the most promising therapeutic strategies for the treatment of cholangiocarcinoma, which is the second most common hepatobiliary cancer. The aim of the present study was to evaluate the enhanced therapeutic effects of HSV-TK/GCV with gemcitabine on cholangiocarcinoma. QBC939 cholangiocarcinoma cells and mouse models of cholangiocarcinoma (established via tumor xenografts) received one of the following treatments: i) Gemcitabine therapy (3 µg/ml); ii) HSV-TK/GCV monotherapy; iii) HSV-TK/GCV + gemcitabine; and iv) control group, treated with phosphate-buffered saline...
July 2016: Experimental and Therapeutic Medicine
Satoshi Takeuchi
Uterine cervical adenocarcinoma (ADC) has been increasing in its prevalence world widely despite the decrease of squamous cell carcinoma (SCC). It comprises nearly 20-25% of the all cervical malignancy in developed countries. The worse biological behavior had been reported in patients with intermediate- and high risk factors after surgery, and in advanced stage over Ⅲ, radiotherapy (RT) alone and concurrent chemo-radiotherapy (CCRT) with cisplatin was not always effective. As for chemotherapy (CT), the induction CT has not established, as well...
April 2016: Chinese Journal of Cancer Research, Chung-kuo Yen Cheng Yen Chiu
Julia Acuña, Karina Rdz-Navarro, Gabriela Huepe, Alberto Botto, Marcelo Cárcamo, Juan Pablo Jiménez
BACKGROUND: Diverse and sustained efforts have been developed to improve the management of depression by general practitioners (GPs), but they have not improved treatment coverage and quality of services. AIM: To explore the level of knowledge and clinical skills to diagnose and treat depression by GPs in Primary Health Care (PHC) in the Metropolitan Area of Santiago de Chile (RM). MATERIAL AND METHODS: Theoretical knowledge (TK), diagnostic skills (DS) and treatment skills (TS) were evaluated in 56 GPs of the RM with a battery of specially designed instruments...
January 2016: Revista Médica de Chile
Satoshi Asakura
Many studies of social anxiety disorder (SAD) have been conducted because diagnostic criteria are defined as social phobia in DSM-III in the West. In Japan, several studies have examined pathological conditions similar to SAD, known as taijin-kyofu (TK). This highly remarkable disorder involves a convincing fear of giving another person discomfort from one's physical faults (e.g. feeling that neighboring people detect an unpleasant smell from one's body, "jikoshu-kyofu", or feeling that neighboring people feel unpleasant because of one's appearance,"shukei-kyofu") termed "convinced subtype of TK" (c-TK; also known as offensive subtype of TK)...
2015: Seishin Shinkeigaku Zasshi, Psychiatria et Neurologia Japonica
Bin Lin, Wen-Bin Zhang, Tao-yi Cai, Cheng-Wu Lu, Qin Zhou, Zhuanzhi Huang, Hui Yu
This study was designed to explore the change of spinopelvic parameters after vertebral column decancellation (VCD) for the management of thoracolumbar kyphosis secondary to ankylosing spondylitis (AS). Forty-two AS patients including thirty-six males and six females with thoracolumbar kyphosis, who underwent VCD from April 2005 to June 2012 in our hospital, were retrospectively reviewed. A series of spinopelvic parameters including thoracic kyphosis (TK), lumbar lordosis (LL), sacral slope (SS), pelvic incidence (PI), pelvic tilt (PT) and sagittal vertical axis (SVA) measured on preoperative and postoperative free-standing radiographs were obtained and analyzed...
September 2015: Acta Orthopaedica Belgica
Ibrahim Obeid, Féthi Laouissat, Anouar Bourghli, Louis Boissière, Jean-Marc Vital
STUDY DESIGN: A case series of seven consecutive patients with L5-S1 spondyloptosis (SPP) and Meyerding IV spondylolisthesis (HGSPL) treated consecutively by a new surgical technique with partial reduction and fixation after spinal shortening. OBJECTIVE: To report clinical and radiological outcomes of a spinal shortening procedure by a single posterior approach in seven patients with HGSPL and SPP. BACKGROUND DATA: The surgical treatment of L5-S1 SPP and HGSPL remains challenging, and numbers of surgical treatment options have been described with several principles...
February 2016: European Spine Journal
Lucia De Franceschi, Paolo Mura, Vittorio Schweiger, Elisa Vencato, Francesca Maria Quaglia, Letizia Delmonte, Maurizio Evangelista, Enrico Polati, Oliviero Olivieri, Gabriele Finco
BACKGROUND: Sickle cell disease (SCD) is a worldwide distributed hereditary red cell disorder. The principal clinical manifestations of SCD are the chronic hemolytic anemia and the acute vaso-occlusive crisis (VOCs), which are mainly characterized by ischemic/reperfusion tissue injury. Pain is the main symptom of VOCs, and its management is still a challenge for hematologists, requiring a multidisciplinary approach. METHODS: We carried out a crossover study on adult SCD patients, who received two different types of multimodal analgesia during two separate severe VOCs with time interval between VOCs of at least 6 months...
2016: Pain Practice: the Official Journal of World Institute of Pain
Hollenbeck Brent
PURPOSE: After being diagnosed with prostate cancer men must assimilate information regarding the cancer. Satisfaction with information reflects the evaluation of information sources used before treatment to select a therapy. We describe the use and helpfulness of several information sources available to prostate cancer survivors. We also identified factors associated with satisfaction with information. MATERIALS AND METHODS: A total of 1,204 men with newly diagnosed prostate cancer were enrolled in the prospective, multicenter Prostate Cancer Outcomes and Satisfaction with Therapy Quality Assessment study...
May 2016: Urologic Oncology
Konan Gervais N'Zi, Stanislas Silvain Yao, Gouli Gooré Bi, Valentin Ndouba
The general aim of this study is to update the inventory of the fish species and to specify distribution patterns in the Nero River ichthyofauna in order to establish some basis for the conservation of these fish communities and their habitat. From February 2009 to January 2010, thirty-three sites were sampled monthly with gill nets and a backpack electrofisher, and environmental variables were recorded. Overall, 46 species included in 33 genuses, 24 families and 9 orders were collected. Eleven families and 30 species were the first records for the Nero River...
May 2015: Saudi Journal of Biological Sciences
Torben K Becker, James F Skiba, Cemal B Sozener
BACKGROUND: Patient transfers among medical facilities are high-risk situations. Despite this, there is very little training of physicians regarding the medical and legal aspects of transport medicine. OBJECTIVES: To examine the effects of a one hour, educational intervention on Emergency Medicine (EM) residents' and Critical Care (CC) fellows' knowledge regarding the medical and legal aspects of interfacility patient transfers. METHODS: Prior to the intervention, physician knowledge regarding 12 key concepts in patient transfer was assessed using a pre-test instrument...
June 2015: Prehospital and Disaster Medicine
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