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Endocrine disruptor

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https://www.readbyqxmd.com/read/28723268/assay-of-calcium-transients-and-synapses-in-rat-hippocampal-neurons-by-kinetic-image-cytometry-and-high-content-analysis-an-in-vitro-model-system-for-postchemotherapy-cognitive-impairment
#1
Patrick M McDonough, Natalie L Prigozhina, Ranor C B Basa, Jeffrey H Price
Postchemotherapy cognitive impairment (PCCI) is commonly exhibited by cancer patients treated with a variety of chemotherapeutic agents, including the endocrine disruptor tamoxifen (TAM). The etiology of PCCI is poorly understood. Our goal was to develop high-throughput assay methods to test the effects of chemicals on neuronal function applicable to PCCI. Rat hippocampal neurons (RHNs) were plated in 96- or 384-well dishes and exposed to test compounds (forskolin [FSK], 17β-estradiol [ES]), TAM or fulvestrant [FUL], aka ICI 182,780) for 6-14 days...
July 2017: Assay and Drug Development Technologies
https://www.readbyqxmd.com/read/28715785/prenatal-exposure-estimation-of-bpa-and-dehp-using-integrated-external-and-internal-dosimetry-a-case-study
#2
M A Martínez, J Rovira, R Prasad Sharma, M Nadal, M Schuhmacher, V Kumar
Prenatal exposure to Endocrine disruptors (EDs), such as Bisphenol A (BPA) and di (2-ethylhexyl) phthalate (DEHP), has been associated with obesity and diabetes diseases in childhood, as well as reproductive, behavioral and neurodevelopment problems. The aim of this study was to estimate the prenatal exposure to BPA and DEHP through food consumption for pregnant women living in Tarragona County (Spain). Probabilistic calculations of prenatal exposure were estimated by integrated external and internal dosimetry modelling, physiologically based pharmacokinetic (PBPK) model, using a Monte-Carlo simulation...
July 14, 2017: Environmental Research
https://www.readbyqxmd.com/read/28711850/urinary-phthalate-metabolites-over-the-first-15months-of-life-and-risk-assessment-check-cohort-study
#3
Sunmi Kim, Jangwoo Lee, Jeongim Park, Hai-Joong Kim, Geum Joon Cho, Gun-Ha Kim, So-Hee Eun, Jeong Jae Lee, Gyuyeon Choi, Eunsook Suh, Sooran Choi, Sungjoo Kim, Sung Koo Kim, Young Don Kim, Su Young Kim, Seunghyo Kim, Soyong Eom, Hyo-Bang Moon, Sungkyoon Kim, Kyungho Choi
Phthalates are important group of endocrine disruptors. Infants and young children are susceptible to phthalate exposure. However, information on the phthalate exposure during the early stages of life is very limited. This study was conducted to understand the temporal trend of exposure to major phthalates among infants of Korea during the first 15months after birth, and to estimate associated risks. A total of 286 urine samples were collected from 171 children at 3, 9, 12, or 15months of age, with 77 children sampled for two or more times...
July 13, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28709042/perinatal-exposure-of-pregnant-rats-to-cypermethrin-delays-testicular-descent-impairs-fertility-in-f1-male-progeny-leading-to-developmental-defects-in-f2-generation
#4
Dipty Singh, Sharad Bhagat, Paula Raijiwala, Vikas Dighe, Geeta Vanage
Cypermethrin (CYP) is a widely used synthetic pyrethroid insecticide and regarded as a potential endocrine disruptor. CYP exposure may pose a great risk to human health including adverse effect on their reproductive functions. This study aimed to delineate the effects of perinatal exposure of rats to CYP on the sexual maturation and fertility of F1 male progeny. Pregnant rats (F0) were gavaged daily with CYP (0, 1, 10, 25 mg/kg BW/day) and Diethylestilbestrol (DES, 10 μg/kg BW/day), as positive control from gestation day 6 to postnatal day 21...
July 4, 2017: Chemosphere
https://www.readbyqxmd.com/read/28707438/long-term-impact-of-the-endocrine-disruptor-tributyltin-on-male-fertility-following-a-single-acute-exposure
#5
Sumonto Mitra, Ankit Srivastava, Shashi Khandelwal
Declining rate of human fertility is a growing concern, where lifestyle and environmental factors play an important role. We recently demonstrated that tributyltin (TBT), an omnipresent endocrine disruptor, affects testicular cells in vitro. In this study, male Wistar rats were gavaged a single dose of 10, 20, and 30 mg/kg TBT-chloride (TBTC) (to mimic accidental exposure in vivo) and sacrificed on day 3 and day 7, respectively. TBT bioavailability was evaluated by estimating total tin content, and essential metal levels were analyzed along with redox molecules (ROS and GSH/GSSG) to understand the effect on physiological conditions...
July 14, 2017: Environmental Toxicology
https://www.readbyqxmd.com/read/28703301/the-xenoestrogens-biphenol-a-and-nonylphenol-differentially-regulate-metalloprotease-mediated-shedding-of-egfr-ligands
#6
Paulina Urriola-Muñoz, Xue Li, Thorsten Maretzky, David R McIlwain, Tak W Mak, Juan G Reyes, Carl P Blobel, Ricardo D Moreno
The xenoestrogens Bisphenol-A (BPA) and Nonylphenol (NP) are endocrine disruptors used in the plastic polymer industry to manufacture different products for human use. Previous studies have suggested a role of these compounds in the shedding of signaling molecules, such as tumor necrosis factor α (TNF- α). The aim of this work was to evaluate the effect of BPA and NP on the sheddase ADAM17 and its newly discovered regulators iRhom1 and iRhom2 in the release of EGFR-ligands. We report that BPA and NP can stimulate the release of the ADAM17-substrates HB-EGF and TGF- α...
July 13, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/28702205/association-of-arsenobetaine-with-beta-cell-function-assessed-by-homeostasis-model-assessment-homa-in-nondiabetic-koreans-data-from-the-fourth-korea-national-health-and-nutrition-examination-survey-knhanes-2008-2009
#7
Kiook Baek, Namhoon Lee, Insung Chung
BACKGROUND: Arsenic is known as an endocrine disruptor that people are exposed to through various sources such as drinking water and indigestion of marine products. Although some epidemiological and animal studies have reported a correlation between arsenic exposure and diabetes development, there are limited studies regarding the toxic effects of organic arsenic including arsenobetaine on the human body. Here, we analyzed the association between urine arsenobetaine and the homeostasis model assessment of β-cell function (HOMA-β), which is an index for predicting diabetes development and reflecting the function of pancreatic β-cells...
2017: Annals of Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/28694246/management-of-endocrine-disease-polycystic-ovary-syndrome-and-nonalcoholic-fatty-liver-disease
#8
REVIEW
Djuro Macut, Ivana Božić-Antić, Jelica Bjekić-Macut, Konstantinos Tziomalos
Polycystic ovary syndrome (PCOS) is a frequent endocrine disease in women, with a number of metabolic and reproductive consequences. Obesity, insulin resistance (IR) and type 2 diabetes are prominent metabolic characteristics of PCOS and common factors affecting liver function and generating nonalcoholic fatty liver disease (NAFLD). Multiple genes involved in the synthesis of androgens, cytokines and IR, as well as acquired factors, such as endocrine disruptors, could associate the etiopathogenesis of PCOS and NAFLD...
September 2017: European Journal of Endocrinology
https://www.readbyqxmd.com/read/28693900/biodegradation-of-pharmaceuticals-and-endocrine-disruptors-with-oxygen-nitrate-manganese-iv-iron-iii-and-sulfate-as-electron-acceptors
#9
Natalie Schmidt, Declan Page, Andreas Tiehm
Biodegradation of pharmaceuticals and endocrine disrupting compounds was examined in long term batch experiments for a period of two and a half years to obtain more insight into the effects of redox conditions. A mix including lipid lowering agents (e.g. clofibric acid, gemfibrozil), analgesics (e.g. diclofenac, naproxen), beta blockers (e.g. atenolol, propranolol), X-ray contrast media (e.g. diatrizoic acid, iomeprol) as well as the antiepileptic carbamazepine and endocrine disruptors (e.g. bisphenol A, 17α-ethinylestradiol) was analyzed in batch tests in the presence of oxygen, nitrate, manganese (IV), iron (III), and sulfate...
June 27, 2017: Journal of Contaminant Hydrology
https://www.readbyqxmd.com/read/28689150/association-of-urinary-phenolic-compounds-inflammatory-bowel-disease-and-chronic-diarrheal-symptoms-evidence-from-the-national-health-and-nutrition-examination-survey
#10
Punyanganie S de Silva, Xuan Yang, Joshua R Korzenik, Rose H Goldman, Kristopher L Arheart, Alberto J Caban-Martinez
Endocrine disruptors such as phenolic compounds and parabens may be involved in chronic non-infective disease. While products incorporating these compounds are extensively utilized in consumer and personal products, little is known about their effect on bowel health. Inflammatory bowel disease (IBD) - consisting of the diseases ulcerative colitis and Crohn's disease - and irritable bowel syndrome are common chronic non-infectious diarrheal diseases. Despite limited knowledge on the etiology of IBD, these diseases have increased prevalence in industrialized countries and cause significant impairment to quality of life...
July 6, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28683661/an-efficient-sampling-strategy-for-selection-of-biobank-samples-using-risk-scores
#11
Jonas Björk, Ebba Malmqvist, Lars Rylander, Anna Rignell-Hydbom
AIM: The aim of this study was to suggest a new sample-selection strategy based on risk scores in case-control studies with biobank data. METHODS: An ongoing Swedish case-control study on fetal exposure to endocrine disruptors and overweight in early childhood was used as the empirical example. Cases were defined as children with a body mass index (BMI) ⩾18 kg/m(2) ( n=545) at four years of age, and controls as children with a BMI of ⩽17 kg/m(2) ( n=4472 available)...
July 2017: Scandinavian Journal of Public Health
https://www.readbyqxmd.com/read/28673846/znse-wo3-nano-hetero-assembly-stacked-on-gum-ghatti-for-photo-degradative-removal-of-bisphenol-a-symbiose-of-adsorption-and-photocatalysis
#12
Amit Kumar, Mu Naushad, Anamika Rana, Inamuddin, Preeti, Gaurav Sharma, Ayman A Ghfar, Florian J Stadler, Mohammad R Khan
In this research work we report Gum-ghatti supported ZnSe-WO3 nano-hetero-assembly for solar powered degradation of endocrine disruptor Bisphenol S (BPA). The photocatalyst was characterized by Scanning electron microscopy (SEM), High resolution transmission electron microscopy (HRTEM), Small area electron diffraction (SAED), X-Ray diffraction (XRD), Fourier transform infra red spectroscopy (FTIR), Photoluminescence (PL), Energy dispersive X-ray (EDX), UV-vis spectrophotometry and Brauner Emmet Teller surface area analyzer (BET)...
July 1, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28666593/an-ecotoxicological-approach-to-evaluate-the-effects-of-tourism-impacts-in-the-marine-protected-area-of-la-maddalena-sardinia-italy
#13
V Moschino, M Schintu, A Marrucci, B Marras, N Nesto, L Da Ros
In the Marine Protected Area of La Maddalena Archipelago, environmental protection rules and safeguard measures for nautical activities have helped in reducing anthropogenic pressure; however, tourism related activities remain particularly significant in summer. With the aim of evaluating their impacts, the biomarker approach using transplanted Mytilus galloprovincialis as sentinel organisms coupled with POCIS deployment was applied. Mussels, translocated to four marine areas differently impacted by tourism activities, were sampled before, during and after the tourist season...
June 27, 2017: Marine Pollution Bulletin
https://www.readbyqxmd.com/read/28665274/statistical-approaches-for-estimating-sex-specific-effects-in-endocrine-disruptors-research
#14
Jessie P Buckley, Brett T Doherty, Alexander P Keil, Stephanie M Engel
BACKGROUND: When a biologic mechanism of interest is anticipated to operate differentially according to sex, as is often the case in endocrine disruptors research, investigators routinely estimate sex-specific associations. Less attention has been given to potential sexual heterogeneity of confounder associations with outcomes. When relationships of covariates with outcomes differ according to sex, commonly applied statistical approaches for estimating sex-specific endocrine disruptor effects may produce divergent estimates...
June 23, 2017: Environmental Health Perspectives
https://www.readbyqxmd.com/read/28664489/adsorptive-removal-of-ascertained-and-suspected-endocrine-disruptors-from-aqueous-solution-using-plant-derived-materials
#15
Elisabetta Loffredo, Eren Taskin
The present study deals with the use of low-cost plant-derived materials, namely a biochar, spent coffee grounds, spent tea leaves, and a compost humic acid, for the adsorptive removal from water of two estrogens, 4-tert-octylphenol (OP) and 17-β-estradiol (E2), and two pesticides, carbaryl and fenuron, each spiked at a concentration of 1 mg L(-1). Kinetics and adsorption isotherms have been performed using a batch equilibrium method to measure the sorption capacities of the adsorbents towards the four molecules...
June 29, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28660508/sorption-specificity-and-desorption-hysteresis-of-gibberellic-acid-on-ferrihydrite-compared-to-goethite-hematite-montmorillonite-and-kaolinite
#16
Li Zhang, Fei Liu, Liang Chen
The pesticide gibberellic acid (GA3) is a potential endocrine disruptor and environmental toxin; therefore, research into its environmental fate is warranted. Batch studies were conducted to investigate the sorption and desorption characteristics of GA3 on aquifer media. The results demonstrated special sorption characteristic of GA3 on ferrihydrite compared to goethite, hematite, montmorillonite, and kaolinite, where the sorption kinetics of GA3 on ferrihydrite was fitted well with the pseudo-second-order, Elovich, and intra-particle diffusion models...
June 28, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28652135/endocrine-disruption-of-phenanthrene-in-the-protogynous-dusky-grouper-epinephelus-marginatus-serranidae-perciformes
#17
Mariana Frias de Campos, Fabiana L Lo Nostro, Rodrigo H Da Cuña, Renata Guimarães Moreira
The dusky grouper Epinephelus marginatus is a protogynous hermaphrodite fish, that maintains high levels of plasma steroids as juveniles, as substrates for sex inversion. These fish are exposed to marine pollution from oil spills during cargo handling. Polycyclic aromatic hydrocarbons (PAHs), such as phenanthrene (Phe), are the main crude oil components and are toxic to fish, acting as endocrine disruptors (ED). This is the first study that investigated impacts of Phe as an ED in E. marginatus juveniles. An in vivo sublethal exposure (96h) to Phe was carried out at two concentrations (0...
June 23, 2017: General and Comparative Endocrinology
https://www.readbyqxmd.com/read/28645054/computational-analysis-of-the-toxcast-estrogen-receptor-agonist-assays-to-predict-vitellogenin-induction-by-chemicals-in-male-fish
#18
David A Dreier, Nancy D Denslow, Christopher J Martyniuk
Endocrine disruptors, especially estrogen receptor (ER) agonists, have received considerable research attention. While there are several mechanistic endpoints for ER agonism in the Endocrine Disruptor Screening Program, there have been growing efforts to develop high-throughput screening assays and computational models to reduce testing cost, time, and animal use. For example, there are 16 ER agonist assays and an integrated computational model in ToxCast. In the present study, we examined the relationship between ToxCast ER agonist assays and model activity to male vitellogenin induction in the Fish-Short Term Reproduction Assay...
July 2017: Environmental Toxicology and Pharmacology
https://www.readbyqxmd.com/read/28640485/pyrethroid-concentrations-and-persistence-following-indoor-application
#19
Lia Emi Nakagawa, Alan Roberto Costa, Ricardo Polatto, Cristiane Mazarin do Nascimento, Solange Papini
Residential indoor environments are potential sources of exposure to pyrethroids, which have low acute toxicity to humans but are allergenic and suspected endocrine disruptors. The present study evaluated the persistence of the pyrethroids cypermethrin and beta-cyfluthrin on indoor surfaces and in house dust. Cypermethrin and beta-cyfluthrin were applied and maintained on aluminum foils and in dust samples for 112 d under controlled conditions and for 12 mo in a test house; periodically, they were quantified by high-performance liquid chromatography...
June 22, 2017: Environmental Toxicology and Chemistry
https://www.readbyqxmd.com/read/28637041/the-effects-of-fungicides-on-human-3%C3%AE-hydroxysteroid-dehydrogenase-1-and-aromatase-in-human-placental-cell-line-jeg-3
#20
Shuyan Cao, Leping Ye, Ying Wu, Baiping Mao, Lanlan Chen, Xiudi Wang, Ping Huang, Ying Su, Ren-Shan Ge
Placenta secretes a large amount of progesterone and estradiol, which are critical for maintaining pregnancy. In human placenta, 3β-hydroxysteroid dehydrogenase 1 (HSD3B1) catalyzes pregnenolone to form progesterone, and aromatase (CYP19A1) catalyzes testosterone into estradiol. Fungicides display antifungal activities and are widely used to prevent fungal infections in agricultural plants. These chemicals include azoles, such as tebuconazole (TEB), triadimefon (TRI), and vinclozolin (VCZ) or organotins, such as tributyltin (TBT) and tetrabutyltin (TTBT)...
June 22, 2017: Pharmacology
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