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Endocrine disruptor

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https://www.readbyqxmd.com/read/29161229/sex-and-dose-specific-effects-of-maternal-bisphenol-a-exposure-on-pancreatic-islets-of-first-and-second-generation-adult-mice-offspring
#1
Amita Bansal, Cetewayo Rashid, Frances Xin, Changhong Li, Erzsebet Polyak, Anna Duemler, Tom van der Meer, Martha Stefaniak, Sana Wajid, Nicolai Doliba, Marisa S Bartolomei, Rebecca A Simmons
BACKGROUND: Exposure to the environmental endocrine disruptor bisphenol A (BPA) is ubiquitous and associated with the increased risk of diabetes and obesity. However, the underlying mechanisms remain unknown. We recently demonstrated that perinatal BPA exposure is associated with higher body fat, impaired glucose tolerance, and reduced insulin secretion in first- (F1) and second-generation (F2) C57BL/6J male mice offspring. OBJECTIVE: We sought to determine the multigenerational effects of maternal bisphenol A exposure on mouse pancreatic islets...
September 27, 2017: Environmental Health Perspectives
https://www.readbyqxmd.com/read/29158199/male-rat-exposure-to-low-dose-of-di-2-ethylhexyl-phthalate-during-pre-pubertal-pubertal-and-post-pubertal-periods-impact-on-sperm-count-gonad-histology-and-testosterone-secretion
#2
Malha Oudir, Henni Chader, Bachir Bouzid, Kheira Bendisari, Batoul Latreche, Sofiane Boudalia, Mokrane Iguer-Ouada
Di (2-ethylhexyl) phthalate (DEHP) is the most ubiquitous endocrine disruptor in the environment. The present study aimed to investigate the low dose effects of DEHP on the male reproductive system of rats exposed during the pre-pubertal, pubertal and post-pubertal periods. Male Wistar rats were daily gavaged by DEHP from postnatal day (PND) 21 to PND 120 with 0.5, 50 and 5000μg/kg BW/d. A decrease in sperm count of 41%, 24% and 46% was observed at 0.5, 50 and 5000μg/kg BW/d respectively. A decrease of Sertoli cells number was observed at 50 and 5000μg/kg BW/d (22% and 42%, respectively)...
November 17, 2017: Reproductive Toxicology
https://www.readbyqxmd.com/read/29154114/prevalence-and-predictors-of-phthalate-exposure-in-pregnant-women-in-charleston-sc
#3
Abby G Wenzel, John W Brock, Lori Cruze, Roger B Newman, Elizabeth R Unal, Bethany J Wolf, Stephen E Somerville, John R Kucklick
Phthalates are plasticizers commonly detected in human urine due to widespread exposure from PVC plastics, food packaging, and personal care products. Several phthalates are known antiandrogenic endocrine disruptors, which raises concern for prenatal exposure during critical windows of fetal development. While phthalate exposure is ubiquitous, certain demographics are subject to greater or lesser exposure. We sampled urine from 378 pregnant women during the second trimester of gestation living in Charleston, SC, and measured eight urinary phthalate metabolites as biomarkers of phthalate exposure: monobutyl phthalate (MBP), monobenzyl phthalate (MBzP), mono(2-ethylhexyl) phthalate (MEHP), mono(2-ethyl-5-oxohexyl) phthalate (MEOHP), mono(2-ethyl-5-hydroxyhexyl) phthalate (MEHHP), monoethyl phthalate (MEP), monoisobutyl phthalate (MiBP), and monomethyl phthalate (MMP)...
November 8, 2017: Chemosphere
https://www.readbyqxmd.com/read/29153057/sex-dependent-influence-of-developmental-toxicant-exposure-on-group-b-streptococcus-mediated-preterm-birth-in-a-murine-model
#4
Tianbing Ding, Lauren A Lambert, David M Aronoff, Kevin G Osteen, Kaylon L Bruner-Tran
Infectious agents are a significant risk factor for preterm birth (PTB); however, the simple presence of bacteria is not sufficient to induce PTB in most women. Human and animal data suggest that environmental toxicant exposures may act in concert with other risk factors to promote PTB. Supporting this "second hit" hypothesis, we previously demonstrated exposure of fetal mice (F1 animals) to the environmental endocrine disruptor 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) leads to an increased risk of spontaneous and infection-mediated PTB in adult animals...
January 1, 2017: Reproductive Sciences
https://www.readbyqxmd.com/read/29150232/-pathogenesis-genetics-and-diagnosis-of-endometriosis
#5
Emile Daraï, Stéphane Ploteau, Marcos Ballester, Sofiane Bendifallah
Endometriosis is a multifactorial pathology. Trans-tubal reflux theory remains valid. Genetic and epigenetic factors associated with immunological perturbations are involved. The role of endocrine disruptors is discussed although epidemiological studies are contradictory. Therapeutics are primarily based on hormonal treatments but better understanding of pathophysiology should allow targeted non-hormonal therapy. The clinical examination is sometimes negative, which should not eliminate the diagnosis and imposes complementary examinations as best as possible by referents...
November 14, 2017: La Presse Médicale
https://www.readbyqxmd.com/read/29148584/metabolic-effects-of-p-p-dde-on-atlantic-salmon-hepatocytes
#6
Pål A Olsvik, Liv Søfteland
Decades after being banned in many countries, DDT and its metabolites are still considered major environmental hazards. The p,p'-DDE isomer, the DDT metabolite found in highest concentration in aquaculture feeds, is an endocrine disruptor with demonstrated ability to induce epigenetic effects. This study aimed at examining the impact of p,p'-DDE on Atlantic salmon. Primary hepatocytes were exposed to four concentrations of p,p'-DDE (0.1, 1, 10, 100 μm) for 48 hours, and endpoints included cytotoxicity, global DNA methylation, targeted transcription and metabolomics profiling (100 μm)...
November 17, 2017: Journal of Applied Toxicology: JAT
https://www.readbyqxmd.com/read/29148069/long-term-oral-exposure-to-safe-dose-of-bisphenol-a-in-association-with-high-fat-diet-stimulate-the-prostatic-lesions-in-a-rodent-model-for-prostate-cancer
#7
Camila H Facina, Silvana G P Campos, Bianca F Gonçalves, Rejane M Góes, Patricia S L Vilamaior, Sebastião R Taboga
BACKGROUND: Studies have shown that exposure to environmental chemicals known as endocrine disruptors can cause permanent changes in genital organs, such as the prostate. Among these environmental chemicals stands out bisphenol A (BPA). Another factor associated with prostate changes is the consumption of a high-fat diet. Although the relationship between the consumption of a high-fat diet and an increased risk of prostate cancer is well established, the mechanisms that lead to the establishment of this disease are not completely understood, nor the simultaneous action of BPA and high-fat diet...
November 17, 2017: Prostate
https://www.readbyqxmd.com/read/29147953/impact-of-perfluorochemicals-on-human-health-and-reproduction-a-male-s-perspective
#8
REVIEW
C Foresta, S Tescari, A Di Nisio
Perfluoroalkyl compounds (PFCs) are a class of organic molecules used in industry and consumer products. PFCs are non-biodegradable and bioaccumulate in the environment and for these reasons they have been a major subject of research regarding their toxicity, environmental fate, and sources of human exposure, since they have been shown to induce severe health consequences, such as neonatal mortality, neurotoxicity and immunotoxicity. The aim of this review is to explore the existing knowledge of the interplay between PFCs exposure and human health, with a focus on male reproductive health, given the emerging gender differences in PFCs clearance and their interaction with sex hormones receptors...
November 17, 2017: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/29146384/identification-of-candidate-reference-chemicals-for-in-vitro-steroidogenesis-assays
#9
Caroline Lucia Pinto, Kristan Markey, David Dix, Patience Browne
The Endocrine Disruptor Screening Program (EDSP) is transitioning from traditional testing methods to integrating ToxCast/Tox21 in vitro high-throughput screening assays for identifying chemicals with endocrine bioactivity. The ToxCast high-throughput H295R steroidogenesis assay may potentially replace the low-throughput assays currently used in the EDSP Tier 1 battery to detect chemicals that alter the synthesis of androgens and estrogens. Herein, we describe an approach for identifying in vitro candidate reference chemicals that affect the production of androgens and estrogens in models of steroidogenesis...
November 13, 2017: Toxicology in Vitro: An International Journal Published in Association with BIBRA
https://www.readbyqxmd.com/read/29146212/the-current-environmental-levels-of-endocrine-disruptors-mercury-cadmium-organochlorine-pesticides-and-pcbs-in-a-belgian-adult-population-and-their-predictors-of-exposure
#10
Catherine Pirard, Stephanie Compere, Katty Firquet, Corinne Charlier
A human biomonitoring study was carried out measuring the levels of endocrine disruptors in 252 participants (18-76 years old) recruited between February and May 2015 from the general population of Liege Province (Belgium). In this study, we reported the recent levels of cadmium and mercury in urine, some organochlorine pesticides and polychlorinated biphenyls (PCBs) in serum, and their relations to demographic characteristics, lifestyle behaviors and dietary habits. The median urinary levels of mercury and cadmium were 0...
October 31, 2017: International Journal of Hygiene and Environmental Health
https://www.readbyqxmd.com/read/29145569/immune-system-an-emerging-player-in-mediating-effects-of-endocrine-disruptors-on-metabolic-health
#11
Amita Bansal, Jorge Henao Mejia, Rebecca A Simmons
The incidence of metabolic disorders like type 2 diabetes and obesity continue to increase. In addition to the well-known contributors such as food intake and sedentary lifestyle, recent research in the exposure science discipline provides new evidence that exposure to endocrine disrupting chemicals like bisphenol A and phthalates via multiple routes (food, drink and skin contact) also contribute to the increased risk of metabolic disorders. Endocrine disrupting chemicals (EDCs) can disrupt any aspect of hormone action...
November 14, 2017: Endocrinology
https://www.readbyqxmd.com/read/29139221/evaluation-of-hypothalamus-pituitary-thyroid-axis-function-by-chronic-perchlorate-exposure-in-male-rats
#12
Caroline Serrano-Nascimento, Jamile Calil-Silveira, Rafael Dalbosco, Telma Tenorio Zorn, Maria Tereza Nunes
Perchlorate is a widespread endocrine disruptor that was previously correlated with increased serum TSH levels and decreased thyroid hormones production both in animals and humans. Even so, the regulation of gene/protein expression in the hypothalamus, pituitary and thyroid by chronic perchlorate exposure was not completely elucidated. Therefore, this study aimed to investigate the underlying mechanisms involved in the disruption of hypothalamus-pituitary-thyroid axis by chronic perchlorate exposure. Male Wistar rats were treated or not with NaClO4 in the drinking water (35 mg/Kg/day) for 60 days...
November 15, 2017: Environmental Toxicology
https://www.readbyqxmd.com/read/29137783/probing-the-radical-chemistry-and-the-reaction-zone-during-the-sono-degradation-of-endocrine-disruptor-2-phenoxyethanol-in-water
#13
Zineb Boutamine, Oualid Hamdaoui, Slimane Merouani
Sonochemical degradation at 600 kHz of 2-phenoxyethanol (PhE), an endocrine disrupting compound, was performed in the presence of several organic additives, namely: 2-propanol, Triton X-100 and sucrose, of different volatilities to obtain detailed information on the reaction zone and the oxidation pathway of this priority emerging water contaminate. It was found that sonication at 600 kHz and 120 W completely remove PhE (10 mg L(-1)) from aerated solutions within 100 min of irradiation. Very little removal of PhE (∼7%) and low accumulation of H2O2 took place in the presence of adequate amount of 2-propanol, indicating that reaction with OH radical outside the bubble is the major degradation pathway of PhE...
March 2018: Ultrasonics Sonochemistry
https://www.readbyqxmd.com/read/29137705/novel-approach-to-high-throughput-determination-of-endocrine-disruptors-using-recycled-diatomaceous-earth-as-a-green-sorbent-phase-for-thin-film-solid-phase-microextraction-combined-with-96-well-plate-system
#14
Nicolas Kirschner, Adriana Neves Dias, Dilma Budziak, Cristian Berto da Silveira, Josias Merib, Eduardo Carasek
A sustainable approach to TF-SPME is presented using recycled diatomaceous earth, obtained from a beer purification process, as a green sorbent phase for the determination of bisphenol A (BPA), benzophenone (BzP), triclocarban (TCC), 4-methylbenzylidene camphor (4-MBC) and 2-ethylhexyl-p-methoxycinnamate (EHMC) in environmental water samples. TF-SPME was combined with a 96-well plate system allowing for high-throughput analysis due to the simultaneous extraction/desorption up to 96 samples. The proposed sorbent phase exhibited good stability in organic solvents, as well as satisfactory analytical performance...
December 15, 2017: Analytica Chimica Acta
https://www.readbyqxmd.com/read/29136846/determination-of-bisphenols-with-estrogenic-activity-in-plastic-packaged-baby-food-samples-using-solid-liquid-extraction-and-clean-up-with-dispersive-sorbents-followed-by-gas-chromatography-tandem-mass-spectrometry-analysis
#15
M T García-Córcoles, M Cipa, R Rodríguez-Gómez, A Rivas, F Olea-Serrano, J L Vílchez, A Zafra-Gómez
Bisphenols (BPs) are a family of chemicals with known endocrine disrupting activity. Bisphenol A (BPA) is the most representative prototype of this group of chemicals. Recently, the use of BPA, a prototype of endocrine disruptors, has been reduced and replaced with structural analogs due to its negative effects on both the environment and consumers. In this work, a new method is presented for the determination of seven BPs, with estrogenic activity in ready-to-eat plastic packaged baby foods. The procedure involves the isolation of the analytes using solid-liquid phase extraction with acetonitrile followed by a clean-up step with a mixture of dispersive-SPE sorbents (C18 and PSA) and magnesium sulphate, to reduce matrix effect from proteins, sugars and lipids...
February 1, 2018: Talanta
https://www.readbyqxmd.com/read/29132025/micro-quechers-extraction-coupled-to-gc-ms-for-a-fast-determination-of-bisphenol-a-in-human-urine
#16
Luísa Correia-Sá, Sónia Norberto, Cristina Delerue-Matos, Conceição Calhau, Valentina F Domingues
Bisphenol A (BPA) is considered an endocrine disruptor and public concern over BPA exposure has been raised. Several studies have assessed human exposure to this plasticizer, confirming its ubiquitous presence and highlighting children as a public of special concern. A simple, efficient, cheap and green analytical procedure is reported within this paper. This paper reports, for the first time, the development of a modified Micro-QuEChERS (Quick, Easy, Cheap, Effective, Rugged and Safe) method coupled to gas chromatography-mass spectrometry (GC-MS) as a new strategy for the efficient extraction and determination of Bisphenol A in human urine samples...
November 8, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/29126515/endocrine-disruptors-eds-and-hormone-dependent-cancers-correlation-or-causal-relationship
#17
Henri Rochefort
The selective increase in the incidence of hormone-dependent cancers (breast, prostate, testicular) in industrialized countries is associated with the increasing number of endocrine disruptors (EDs) in the environment and raises questions about the role of EDs in mammary carcinogenesis. Answering these questions is difficult because the number of EDs is large and varies with time. Moreover hormonal carcinogenesis is multifactorial and progresses slowly and in stages. This discussion will be limited to breast cancer and three EDs: distilbene, bisphenol A (BPA), and dichlorodiphenyltrichloroethane (DDT)...
September 2017: Comptes Rendus Biologies
https://www.readbyqxmd.com/read/29126514/structural-and-functional-evidences-for-the-interactions-between-nuclear-hormone-receptors-and-endocrine-disruptors-at-low-doses
#18
Patrick Balaguer, Vanessa Delfosse, Marina Grimaldi, William Bourguet
Endocrine-disrupting chemicals (EDCs) represent a broad class of exogenous substances that cause adverse effects in the endocrine system mainly by interacting with nuclear hormone receptors (NRs). Humans are generally exposed to low doses of pollutants, and current researches aim at deciphering the mechanisms accounting for the health impact of EDCs at environmental concentrations. Our correlative analysis of structural, interaction and cell-based data has revealed a variety of, sometimes unexpected, binding modes, reflecting a wide range of EDC affinities and specificities...
September 2017: Comptes Rendus Biologies
https://www.readbyqxmd.com/read/29126513/endocrine-disruptors-revisiting-concepts-and-dogma-in-toxicology
#19
Robert Barouki
During the last decades, a large number of observations have shown that some exogenous substances could interfere with hormone levels or hormone action and could induce toxic effects. This has led to the identification of endocrine disruptors more than 25 years ago as a new class of toxic agents (Zoeller et al., 2014). Those widely used agents correspond to a variety of chemical classes, are not identified by their chemical structure or by a specific type of usage, but rather by their mechanisms of action; this is not unprecedented in toxicology since genotoxicants have also been identified by their mechanism of action, i...
September 2017: Comptes Rendus Biologies
https://www.readbyqxmd.com/read/29126512/what-is-an-endocrine-disruptor
#20
Claude Monneret
Endocrine disrupting chemicals (EDCs) and potential EDCs are mostly man-made found in various materials. By interfering with the body's endocrine system, endocrine disruptors produce adverse developmental, reproductive, neurological, and immune effects in humans, abnormal growth patterns and neurodevelopmental delays in children. Thus, diethylstilbestrol (DES) a non-steroidal estrogen, which is regarded as a proof of concept, induces clear cell carcinoma among young women. EDCS may be found in plastic bottles and metal food cans (BPA), medical devices (phthalates), detergents, flame retardants (polybrominated diphenyl ethers), food (BPA), toys (phthalates), cosmetics and drugs (parabens), and pesticides (alkyl phenols such as nonylphenol)...
September 2017: Comptes Rendus Biologies
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