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Endocrine disruptor

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https://www.readbyqxmd.com/read/28812018/effects-of-fungicides-on-rat-s-neurosteroid-synthetic-enzymes
#1
Xiuwei Shen, Fan Chen, Lanlan Chen, Ying Su, Ping Huang, Ren-Shan Ge
Exposure to environmental endocrine disruptors may interfere with nervous system's activity. Fungicides such as tebuconazole, triadimefon, and vinclozolin have antifungal activities and are used to prevent fungal infections in agricultural plants. In the present study, we studied effects of tebuconazole, triadimefon, and vinclozolin on rat's neurosteroidogenic 5α-reductase 1 (5α-Red1), 3α-hydroxysteroid dehydrogenase (3α-HSD), and retinol dehydrogenase 2 (RDH2). Rat's 5α-Red1, 3α-HSD, and RDH2 were cloned and expressed in COS-1 cells, and effects of these fungicides on them were measured...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28805487/state-of-the-art-nanopathological-diagnostics
#2
Luca Roncati, Giuseppe Barbolini
The nanopathological diagnostics (ND) is an ultra-specialized branch of pathological anatomy aimed to identify the nanoparticles of metallic, semimetallic, or nonmetallic elements in the inorganic particulate matter present inside pathological tissues, even on the nanometer scale. ND exploits an environmental scanning electron microscope, connected to an X-ray microprobe mounted on an energy-dispersive spectrometer. The searching of nanoparticles can be performed on paraffin-embedded material, omitting emissions of black overlay and plating procedures...
August 14, 2017: Ultrastructural Pathology
https://www.readbyqxmd.com/read/28802108/do-environmental-factors-affect-male-fathead-minnow-pimephales-promelas-response-to-estrone-part-2-temperature-and-food-availability
#3
N W Shappell, D J Feifarek, D C Rearick, S E Bartell, H L Schoenfuss
Fish are subject to constantly changing environmental conditions and food availability, factors that may impact their response to endocrine disruptors (EDs). This may, in part, explain outcome discrepancies between field studies and laboratory exposures to EDs. This study assessed whether standard laboratory conditions for fish exposures adequately represent effects of ED exposure at two environmentally realistic temperatures. The impact of temperature and food availability on male fathead minnow response to estrone (E1) exposure was studied in two experiments (3×2×2 factorial design) with three E1 concentrations (range 0-135ng/L); two temperatures (18°C and 26°C, the latter the prescribed laboratory temperature), and two feeding treatments (full fed vs...
August 9, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28801138/cadmium-exposure-in-newborn-rats-ovary-induces-developmental-disorders-of-primordial-follicles-and-the-differential-expression-of-scf-c-kit-gene
#4
Wenchang Zhang, Tingting Wu, Chenyun Zhang, Lingfeng Luo, Meimei Xie, Huiling Huang
Since the 1990s, the rising problem that gonad reproductive toxicity on adult female after exposing to cadmium (Cd), an environmental endocrine disruptor, has attracted high attention at home and abroad,and was systematically studied. Our research focuses on a further problem is that early cadmium exposure (during birth to before puberty) impact on development and function of ovarian cells and its possible mechanism. Our research focuses on the changes of ovarian cells growth and development after the newborn rat ovaries with cadmium exposure in vitro, and different expression of ovarian cells development-related factors, SCF/c-kit and changes of their DNA methylation status...
August 8, 2017: Toxicology Letters
https://www.readbyqxmd.com/read/28801100/neuroendocrine-disruption-in-animal-models-due-to-exposure-to-bisphenol-a-analogues
#5
REVIEW
Cheryl S Rosenfeld
Animal and human studies provide evidence that exposure to the endocrine disrupting chemical (EDC), bisphenol A (BPA), can lead to neurobehavioral disorders. Consequently, there is an impetus to identify safer alternatives to BPA. Three bisphenol compounds proposed as potential safer alternatives to BPA are bisphenol S (BPS), bisphenol F (BPF), and bisphenol AF (BPAF). However, it is not clear whether these other compounds are safer in terms of inducing less endocrine disrupting effects in animals and humans who are now increasingly coming into contact with these BPA-substitutes...
August 8, 2017: Frontiers in Neuroendocrinology
https://www.readbyqxmd.com/read/28795111/data-describing-lack-of-effects-of-17%C3%AE-ethinyl-estradiol-on-mammary-gland-morphology-in-female-mice-exposed-during-pregnancy-and-lactation
#6
Charlotte D LaPlante, Laura N Vandenberg
Ethinyl estradiol (EE) is a synthetic estrogen used in pharmaceutical contraceptives. In many studies evaluating estrogenic endocrine disruptors, EE is used as a positive control for estrogenicity. However, the effects of EE often differ from the effects of other xenoestrogens, suggesting that these other compounds might act via distinct mechanisms. Reported here are data describing the effect of low doses of EE during pregnancy and lactation on the morphology of the lactating mammary gland in CD-1 mice. The data suggest that these low doses have few if any discernable effects on mammary gland morphology...
October 2017: Data in Brief
https://www.readbyqxmd.com/read/28794470/endocrine-disruptors-induce-perturbations-in-endoplasmic-reticulum-and-mitochondria-of-human-pluripotent-stem-cell-derivatives
#7
Uthra Rajamani, Andrew R Gross, Camille Ocampo, Allen M Andres, Roberta A Gottlieb, Dhruv Sareen
Persistent exposure to man-made endocrine disrupting chemicals during fetal endocrine development may lead to disruption of metabolic homeostasis contributing to childhood obesity. Limited cellular platforms exist to test endocrine disrupting chemical-induced developmental abnormalities in human endocrine tissues. Here we use an human-induced pluripotent stem cell-based platform to demonstrate adverse impacts of obesogenic endocrine disrupting chemicals in the developing endocrine system. We delineate the effects upon physiological low-dose exposure to ubiquitous endocrine disrupting chemicals including, perfluoro-octanoic acid, tributyltin, and butylhydroxytoluene, in endocrine-active human-induced pluripotent stem cell-derived foregut epithelial cells and hypothalamic neurons...
August 9, 2017: Nature Communications
https://www.readbyqxmd.com/read/28790390/involvement-of-insulin-signaling-disturbances-in-bisphenol-a-induced-alzheimer-s-disease-like-neurotoxicity
#8
Tingwei Wang, Cuiwei Xie, Pengfei Yu, Fangfang Fang, Jingying Zhu, Jie Cheng, Aihua Gu, Jun Wang, Hang Xiao
Bisphenol A (BPA), a member of the environmental endocrine disruptors (EDCs), has recently received increased attention because of its effects on brain insulin resistance. Available data have indicated that brain insulin resistance may contribute to neurodegenerative diseases. However, the associated mechanisms that underlie BPA-induced brain-related outcomes remain largely unknown. In the present study, we identified significant insulin signaling disturbances in the SH-SY5Y cell line that were mediated by BPA, including the inhibition of physiological p-IR Tyr1355 tyrosine, p-IRS1 tyrosine 896, p-AKT serine 473 and p-GSK3α/β serine 21/9 phosphorylation, as well as the enhancement of IRS1 Ser307 phosphorylation; these effects were clearly attenuated by insulin and rosiglitazone...
August 8, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28780062/metabolic-disruption-of-zebrafish-danio-rerio-embryos-by-bisphenol-a-an-integrated-metabolomic-and-transcriptomic-approach
#9
Elena Ortiz-Villanueva, Laia Navarro-Martín, Joaquim Jaumot, Fernando Benavente, Victoria Sanz-Nebot, Benjamín Piña, Romà Tauler
Although bisphenol A (BPA) is commonly recognized as an endocrine disruptor, the metabolic consequences of its exposure are still poorly understood. In this study, we present a non-targeted LC-MS based metabolomic analysis in combination with a full-genome, high-throughput RNA sequencing (RNA-Seq) to reveal the metabolic effects and the subjacent regulatory pathways of exposing zebrafish embryos to BPA during the first 120 hours post-fertilization. We applied multivariate data analysis methods to extract biochemical information from the LC-MS and RNA-Seq complex datasets and to perform testable predictions of the phenotypic adverse effects...
August 3, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28774778/frontiers-in-endocrine-disruption-impacts-of-organotin-on-the-hypothalamus-pituitary-thyroid-axis
#10
REVIEW
Ana Paula Santos-Silva, Marcelle Novaes Andrade, Paula Pereira-Rodrigues, Francisca Diana Paiva-Melo, Paula Soares, Jones Bernardes Graceli, Glaecir Roseni Mundstock Dias, Andrea Claudia Freitas Ferreira, Denise Pires de Carvalho, Leandro Miranda-Alves
Endocrine disruptors (EDs), chemical substances widely used in industry and ubiquitously distributed in the environment, are able to interfere with the synthesis, release, transport, metabolism, receptor binding, action, or elimination of endogenous hormones. EDs affect homeostasis mainly by acting on nuclear and nonnuclear steroid receptors but also on serotonin, dopamine, norepinephrine and orphan receptors in addition to thyroid hormone receptors. Tributyltin (TBT), an ED widely used as a pesticide and biocide in antifouling paints, has well-documented actions that include inhibiting aromatase and affecting the nuclear receptors PPARγ and RXR...
July 31, 2017: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/28774687/the-environment-and-male-reproduction-the-effect-of-cadmium-exposure-on-reproductive-system-and-semen-quality-and-its-implication-in-fertility
#11
REVIEW
Cristina de Angelis, Mariano Galdiero, Claudia Pivonello, Ciro Salzano, Daniele Gianfrilli, Prisco Piscitelli, Andrea Lenzi, Annamaria Colao, Rosario Pivonello
Cadmium is an environmental pollutant known as endocrine disruptor. Testis is particularly susceptible to cadmium, and testis injury occurs at high but even low levels of exposure. Cadmium reproductive toxicity is mediated by multiple mechanisms, including structural damage to testis vasculature and blood-testis barrier, inflammation, cytotoxicity on Sertoli and Leydig cells, oxidative stress, apoptosis, epigenetic actions, and disturbance of the hypothalamus-pituitary-gonadal axis. The current review outlines epidemiological observational findings from environmental and occupational exposure in humans, and reports experimental studies in humans and animals...
July 31, 2017: Reproductive Toxicology
https://www.readbyqxmd.com/read/28774668/chronic-exposure-of-2-3-7-8-tetrachlorodibenzo-p-dioxin-tcdd-induces-an-obesogenic-effect-in-c57bl-6j-mice-fed-a-high-fat-diet
#12
Axelle Brulport, Ludovic Le Corre, Marie-Christine Chagnon
Contaminant involvement in the pathophysiology of obesity is widely recognized. It has been shown that low dose and chronic exposure to endocrine disruptor compounds (EDCs) potentiated diet- induced obesity. High and acute exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), a persistent organic pollutant (POP) and an EDC with anti-estrogenic property, causes wasting syndrome . However at lower doses, the TCDD metabolic effects remain poorly understood. We investigated the obesogenic effect during chronic exposure of TCDD at 1μg/kg body weight (bw)/week in adult C57BL/6J mice fed with a high fat diet (HFD) and exposed from 10 to 42 weeks old to TCDD or equal volume of vehicle by intragastric gavage...
July 31, 2017: Toxicology
https://www.readbyqxmd.com/read/28772150/low-dose-developmental-exposure-to-bisphenol-a-induces-sex-specific-effects-in-bone-of-fischer-344-rat-offspring
#13
Thomas Lind, Margareta H Lejonklou, Linda Dunder, Annica Rasmusson, Sune Larsson, Håkan Melhus, P Monica Lind
BACKGROUND: Bisphenol A (BPA) is a component of polycarbonate plastics to which humans are regularly exposed at low levels, and an endocrine disruptor with effects on several hormonal systems. Bone is a sensitive hormone target tissue, and we have recently shown that in utero and lactational exposure to 25µg BPA/kg BW/day alters femoral geometry in rat offspring. OBJECTIVE: To investigate bone effects in rat offspring after developmental exposure to a BPA dose in the range of human daily exposure (0...
July 31, 2017: Environmental Research
https://www.readbyqxmd.com/read/28771440/association-between-urinary-phthalates-and-metabolic-abnormalities-in-obese-thai-children-and-adolescents
#14
Tansit Saengkaew, Chutima Jantarat, Wichit Nosoognoen, Vichit Supornsilchai
BACKGROUND: Several endocrine disruptors (including phthalates) are considered to be a cause of obesity. However, the current evidence has not conclusively established an association between phthalates and metabolic abnormalities, especially in children. The objective of the study was to evaluate the association between urinary phthalate metabolites and metabolic abnormalities in obese Thai children and adolescents. METHODS: This cross-sectional case-control study was conducted in participants aged 7-18 years and divided into two groups: normal weight and overweight/obesity...
August 3, 2017: Journal of Pediatric Endocrinology & Metabolism: JPEM
https://www.readbyqxmd.com/read/28769031/sex-specific-placental-accumulation-and-behavioral-effects-of-developmental-firemaster-550-exposure-in-wistar-rats
#15
Kylie R Baldwin, Allison L Phillips, Brian Horman, Sheryl E Arambula, Meghan E Rebuli, Heather M Stapleton, Heather B Patisaul
Firemaster® 550 (FM 550) is a commercial flame retardant mixture of brominated and organophosphate compounds applied to polyurethane foam used in furniture and baby products. Due to widespread human exposure, and structural similarities with known endocrine disruptors, concerns have been raised regarding possible toxicity. We previously reported evidence of sex specific behavioral effects in rats resulting from developmental exposure. The present study expands upon this prior finding by testing for a greater range of behavioral effects, and measuring the accumulation of FM 550 compounds in placental tissue...
August 2, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28765096/effects-of-bpa-on-global-dna-methylation-and-global-histone-3-lysine-modifications-in-sh-sy5y-cells-an-epigenetic-mechanism-linking-the-regulation-of-chromatin-modifiying-genes
#16
Mine Senyildiz, Ecem Fatma Karaman, Serap Sancar Bas, Pelin Arda Pirincci, Sibel Ozden
Bisphenol A (BPA), an estrogenic endocrine disruptor, is widely used in the production of polycarbonate plastic and epoxy resins, resulting in high risk on human health. In present study we aimed to investigate the effects of BPA on global and gene specific DNA methylation, global histone modifications and regulation of chromatin modifiying enzymes in human neuroblastoma cells (SH-SY5Y). Cells were treated with BPA at 0.1, 1 and 10μM concentrations for 48 and 96h. IC50 value of BPA was determined as 183 and 129μM in SH-SY5Y cells after 24h by MTT and NRU tests, respectively...
July 29, 2017: Toxicology in Vitro: An International Journal Published in Association with BIBRA
https://www.readbyqxmd.com/read/28759207/prolonged-exposure-to-bisphenol-a-from-single-dermal-contact-events
#17
Jiaying Liu, Jonathan W Martin
Bisphenol A (BPA) is an endocrine disruptor frequently detected in human biofluids. Dermal absorption of BPA from thermal paper receipts occurs but BPA pharmacokinetics following dermal exposure is not understood. To compare the pharmacokinetics of dermal and dietary BPA exposure, six male participants handled simulated receipts containing relevant levels of BPA (isotope-labeled BPA-d16) for 5 min, followed by hand-washing 2 hrs later. Urine (0-48 hrs) and serum (0-7.5 hrs) were monitored for free and total BPA-d16...
July 31, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28758506/exposure-to-modern-widespread-environmental-endocrine-disrupting-chemicals-and-their-effect-on-the-reproductive-potential-of-women-an-overview-of-current-epidemiological-evidence
#18
Anetta Karwacka, Dorota Zamkowska, Michał Radwan, Joanna Jurewicz
Growing evidence indicates that exposure to widespread, environmental contaminants called endocrine disruptors (EDCs) negatively affects animal and human reproductive health and has been linked to several diseases including infertility. This review aims to evaluate the impact of environmental exposure to endocrine disrupting chemicals [phthalates, parabens, triclosan, bisphenol A (BPA), organochlorine (PCBs) and perfluorinated (PFCs) compounds] on the reproductive potential among women, by reviewing most recently published literature...
July 31, 2017: Human Fertility: Journal of the British Fertility Society
https://www.readbyqxmd.com/read/28756807/association-between-plasma-metal-levels-and-diabetes-risk-a-case-control-study-in-china
#19
Xiu Ting Li, Peng Fei Yu, Yan Gao, Wen Hui Guo, Jun Wang, Xin Liu, Ai Hua Gu, Gui Xiang Ji, Qiu Dong, Bo Shen Wang, Ying Cao, Bao Li Zhu, Hang Xiao
OBJECTIVE: Many metals, some of which have been classified as environmental endocrine disruptors, are used extensively in everyday consumer products and are ubiquitous in our living environment. In the present study, we aimed to explore the associations between the prevalence risk of type 2 diabetes and plasma levels of 20 trace elements as well as those of heavy metals in a Han Chinese population. METHODS: We conducted a case-control study to investigate the associations between plasma concentrations of 20 metals and diabetes in Jiangsu province...
July 2017: Biomedical and Environmental Sciences: BES
https://www.readbyqxmd.com/read/28754128/does-air-pollution-play-a-role-in-infertility-a-systematic-review
#20
REVIEW
Julie Carré, Nicolas Gatimel, Jessika Moreau, Jean Parinaud, Roger Léandri
BACKGROUND: Air pollution is involved in many pathologies. These pollutants act through several mechanisms that can affect numerous physiological functions, including reproduction: as endocrine disruptors or reactive oxygen species inducers, and through the formation of DNA adducts and/or epigenetic modifications. We conducted a systematic review of the published literature on the impact of air pollution on reproductive function. Eligible studies were selected from an electronic literature search from the PUBMED database from January 2000 to February 2016 and associated references in published studies...
July 28, 2017: Environmental Health: a Global Access Science Source
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