Shruthi Krishnan, Jayakumar Manoharan, Hongjie Wang, Dheerendra Gupta, Sameen Fatima, Yanfei Yu, Akash Mathew, Zhen Li, Shrey Kohli, Constantin Schwab, Antje Körner, Peter R Mertens, Peter Nawroth, Khurrum Shahzad, Michael Naumann, Berend Isermann, Ronald Biemann
Dysfunction of mesangial cells plays a major role in the pathogenesis of diabetic kidney disease (DKD), the leading cause of kidney failure. However, the underlying molecular mechanisms are incompletely understood. By unbiased gene expression analysis of glucose-exposed mesangial cells, we identified the transmembrane receptor CD248 as the most upregulated gene, and the maladaptive unfolded protein response (UPR) as one of the most stimulated pathways. Upregulation of CD248 was further confirmed in glucose-stressed mesangial cells in vitro, in kidney glomeruli isolated from diabetic mice (streptozotocin; STZ and db/db models, representing type 1 and type 2 diabetes mellitus, respectively) in vivo, and in glomerular kidney sections from patients with DKD...
February 2023: Kidney International