Biswadeep Das, Sagnika Samal, Hamida Hamdi, Aditi Pal, Arpita Biswas, Jyotika Behera, Gyanraj Singh, Chinmay Kumar Behera, Debee Prasad Sahoo, Sanghamitra Pati
Dengue virus (DENV) causes debilitating disease in humans, which varies at different rates in host cells, such as monocytes, macrophages, dendritic cells, Langerhans cells, and other cell types. Such heterogeneity in DENV infection in cells could be attributed to a range of factors, including host cell immune response, anti-viral cellular proteins, and virus mediated cellular autophagy. This review delineates an important feature of every cell, the unfolded protein response (UPR) that is attributed to the accumulation of several viral and unfolded/misfolded proteins, such as in DENV infection...
July 28, 2023: Life Sciences