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https://www.readbyqxmd.com/read/28427191/down-regulation-of-long-non-coding-rna-rp11-708h21-4-is-associated-with-poor-prognosis-for-colorectal-cancer-and-promotes-tumorigenesis-through-regulating-akt-mtor-pathway
#1
Longci Sun, Chunhui Jiang, Chunjie Xu, Hanbing Xue, Hong Zhou, Lei Gu, Ye Liu, Qing Xu
Long non-coding RNAs (lncRNAs) serve critical roles in cancer development and progression. Herein, through next generation RNA sequencing and experimental validations, we determined the expression status of RP11-708H21.4 in colorectal cancer (CRC) and explored its clinical significance and biological functions in CRC. Differentially expressed lncRNAs from CRC samples and corresponding normal mucosa tissues was screened through RNA sequencing, and RP11-708H21.4 was selected for further experimental validation...
March 2, 2017: Oncotarget
https://www.readbyqxmd.com/read/28423720/meta-analysis-of-oxaliplatin-based-versus-fluorouracil-based-neoadjuvant-chemoradiotherapy-and-adjuvant-chemotherapy-for-locally-advanced-rectal-cancer
#2
Xing-Li Fu, Zheng Fang, Liang-Hui Shu, Guo-Qing Tao, Jian-Qiang Wang, Zhi-Lian Rui, Yong-Jie Zhang, Zhi-Qiang Tian
A meta-analysis was conducted to compare oxaliplatin-based with fluorouracil-based neoadjuvant chemoradiotherapy and adjuvant chemotherapy for locally advanced rectal cancer. MEDLINE, EMBASE and CENTRAL were systematically searched for relevant randomized controlled trials (RCTs) until January 31 2017. Review Manager (version 5.3) was used to analyze the data. Dichotomous data were calculated by odds ratio (OR) with 95% confidence intervals (CI). A total of 8 RCTs with 6103 stage II or III rectal cancer patients were analyzed, including 2887 patients with oxaliplatin+fluorouracil regimen and 3216 patients with fluorouracil alone regimen...
March 11, 2017: Oncotarget
https://www.readbyqxmd.com/read/28423595/dutpase-inhibition-augments-replication-defects-of-5-fluorouracil
#3
Anna Hagenkort, Cynthia B J Paulin, Matthieu Desroses, Antonio Sarno, Elisée Wiita, Oliver Mortusewicz, Tobias Koolmeister, Olga Loseva, Ann-Sofie Jemth, Ingrid Almlöf, Evert Homan, Thomas Lundbäck, Anna-Lena Gustavsson, Martin Scobie, Thomas Helleday
The antimetabolite 5-Fluorouracil (5-FU) is used in the treatment of various forms of cancer and has a complex mode of action. Despite 6 decades in clinical application the contribution of 5-FdUTP and dUTP [(5-F)dUTP] and 5-FUTP misincorporation into DNA and RNA respectively, for 5-FU-induced toxicity is still under debate.This study investigates DNA replication defects induced by 5-FU treatment and how (5-F)dUTP accumulation contributes to this effect. We reveal that 5-FU treatment leads to extensive problems in DNA replication fork progression, causing accumulation of cells in S-phase, DNA damage and ultimately cell death...
April 4, 2017: Oncotarget
https://www.readbyqxmd.com/read/28423384/cetuximab-carboplatin-5-fluorouracil-regimen-in-elderly-patients-with-recurrent-or-metastatic-head-and-neck-squamous-cell-carcinoma-a-french-retrospective-survey
#4
Mickaël Burgy, Philippe Barthélémy, François Lefevre, Agnès Dupret-Bories, Pierre Truntzer, Clement Korenbaum, Henri Flesch, Guy Bronner, Christian Borel
BACKGROUND: The cetuximab plus platinum-based chemotherapy regimen is a standard of care in the treatment of recurrent or metastatic head and neck squamous-cell carcinoma (HNSCC). The feasibility in the elderly population is currently unknown. METHODS: We performed a retrospective study in order to assess the efficacy and safety of the cetuximab plus platinum-based chemotherapy regimen in patients >65 years with recurrent or metastatic HNSCC. We performed a retrospective review of all medical records from recurrent or metastatic HNSCC patients >65 years treated with the cetuximab plus platinum-based chemotherapy regimen between September 2008 and December 2013 in our institution (Centre Paul Strauss, Strasbourg, France)...
April 20, 2017: Oncology
https://www.readbyqxmd.com/read/28421455/erratum-to-efficacy-and-safety-of-5-fluorouracil-0-5-salicylic-acid-10-in-the-field-directed-treatment-of-actinic-keratosis-a-phase-iii-randomized-double-blind-vehicle-controlled-trial
#5
Eggert Stockfleth, Ralph von Kiedrowski, Rolf Dominicus, John Ryan, Adam Ellery, Meritxell Falqués, Nathalie Ivanoff, Rosario Rodriguez Azeredo
No abstract text is available yet for this article.
April 18, 2017: Dermatology and Therapy
https://www.readbyqxmd.com/read/28421379/role-of-taxanes-in-chemotherapy-related-cognitive-impairment-a-prospective-longitudinal-study
#6
Noemí Cerulla, Àngels Arcusa, José-Blas Navarro, Maite Garolera, Cristina Enero, Glòria Chico, Luís Fernández-Morales
PURPOSE: The aim of this study is to elucidate the role of taxanes on cognition when they are administered as a part of the treatment with a fluorouracil, epirubicin and cyclophosphamide (FEC) regimen for breast cancer (BC). METHODS: Two groups of women (n = 51) with a novel diagnostic of BC that were treated with a combination of FEC alone (6 cycles of FEC) or with taxanes (4 cycles of FEC plus 8 cycles of taxanes) were compared at three moments: before chemotherapy, after its completion (short-term evaluation) and at a mean of 74...
April 18, 2017: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/28420003/retrospective-analysis-of-the-risk-factors-for-grade-iv-neutropenia-in-oesophageal-cancer-patients-treated-with-a-docetaxel-cisplatin-and-5-fluorouracil-regimen
#7
Masahito Naito, Tomoya Yamamoto, Chikao Shimamoto, Yoshihiro Miwa
BACKGROUND: Previous Japanese trials of the docetaxel, cisplatin, and 5-fluorouracil regimen for oesophageal cancer have demonstrated that a large proportion of patients also develop grade IV neutropenia. Our aim was to examine the risk factors for neutropenia in patients treated with this regimen. METHODS: We retrospectively analysed the risk factors for developing grade IV neutropenia in 66 patients with oesophageal cancer using a multivariate analysis. RESULTS: After administering the docetaxel, cisplatin, and 5-fluorouracil regimen, 49 patients (74...
April 19, 2017: Chemotherapy
https://www.readbyqxmd.com/read/28417167/gene-expression-levels-of-gamma-glutamyl-hydrolase-in-tumor-tissues-may-be-a-useful-biomarker-for-the-proper-use-of-s-1-and-tegafur-uracil-leucovorin-in-preoperative-chemoradiotherapy-for-patients-with-rectal-cancer
#8
Sotaro Sadahiro, T Suzuki, A Tanaka, K Okada, G Saito, H Miyakita, T Ogimi, H Nagase
PURPOSE: Preoperative chemoradiotherapy (CRT) using 5-fluorouracil (5-FU)-based chemotherapy is the standard of care for rectal cancer. The effect of additional chemotherapy during the period between the completion of radiotherapy and surgery remains unclear. Predictive factors for CRT may differ between combination chemotherapy with S-1 and with tegafur-uracil/leucovorin (UFT/LV). METHODS: The subjects were 54 patients with locally advanced rectal cancer who received preoperative CRT with S-1 or UFT/LV...
April 17, 2017: Cancer Chemotherapy and Pharmacology
https://www.readbyqxmd.com/read/28416637/a-kinase-independent-role-for-cdk19-in-p53-response
#9
K Audrey Audetat, Matthew D Galbraith, Aaron T Odell, Thomas Lee, Ahwan Pandey, Joaquin M Espinosa, Robin D Dowell, Dylan J Taatjes
The human Mediator complex regulates RNA Polymerase II transcription genome-wide. A general factor that regulates Mediator function is the four-subunit kinase module, which contains either CDK8 or CDK19. Whereas CDK8 is linked to specific signaling cascades and oncogenesis, the cellular roles of its paralog, CDK19, are poorly studied. We discovered that osteosarcoma cells (SJSA) are naturally depleted of CDK8 protein. Whereas stable CDK19 knockdown was tolerated in SJSA cells, proliferation was reduced. Notably, proliferation defects were rescued upon re-expression of wild-type or kinase-dead CDK19...
April 17, 2017: Molecular and Cellular Biology
https://www.readbyqxmd.com/read/28416328/hepatoprotective-mongolian-prescription-ii-enhances-the-antitumor-effects-of-chemotherapeutics-in-hepatocellular-carcinoma-xenografts
#10
A Nanda, Qimuge Suyila, Li Xian, Su Xiulan
Hepatoprotective Mongolian prescription II (MPII), a mixture of 18 different medicinal herbs, significantly inhibited the growth of human liver cancer cell lines Huh-7 and HepG2 in vitro with different concentrations; MPII (6mg/mL) inhibited cell proliferation by 80.48%. MPII induced apoptosis in both cell lines, which was observed by light microscopy and flow cytometry. MPII-induced apoptosis and G0/G1 cell cycle arrest were quantified by Annexin V-FITC/PI staining and flow cytometry. At the molecular level, MPII induced caspase-3, caspase-8, caspase-9, and cytochrome c gene expression...
January 18, 2017: Pathology, Research and Practice
https://www.readbyqxmd.com/read/28415810/comparison-of-two-transarterial-chemoembolization-regimens-in-patients-with-unresectable-hepatocellular-carcinoma-raltitrexed-plus-oxaliplatin-versus-5-fluorouracil-plus-oxaliplatin
#11
Wei Cui, Wenzhe Fan, Qun Zhang, Jia Wen, Yonghui Huang, Jianyong Yang, Jiaping Li, Yu Wang
AIMS: To compare the safety and efficacy of TACE using raltitrexed, oxaliplatin and epirubicin with 5-fluorouracil, oxaliplatin and epirubicin for patients with unresectable hepatocelluar carcinoma. RESULTS: Median overall survival (OS) was 7.4 months in the raltitrexed group [95% confidence interval (CI): 5.4, 9.4) and 5.8 months in the control group (95% CI: 5.2, 6.4; P = 0.177). The median progression-free survival (PFS) time was significantly higher in the raltitrexed group (3...
March 16, 2017: Oncotarget
https://www.readbyqxmd.com/read/28415615/a-nation-wide-multicenter-10-year-1999-2008-retrospective-study-of-chemotherapy-in-chinese-breast-cancer-patients
#12
Qiao Li, Zhao Yang, Jinhu Fan, Jianjun He, Bin Zhang, Hongjian Yang, Xiaoming Xie, Zhonghua Tang, Hui Li, Youlin Qiao, Pin Zhang
Little information is available on the evolvement of chemotherapeutic regimens administered to Chinese females with breast cancer. We retrospectively analyzed demographic, pathological and chemotherapeutic data of 4211 breast cancer patients, who were randomly selected from representative hospitals of 7 traditional areas in China between 1999 and 2008. A total of 3271 cases (77.7%) received adjuvant chemotherapy, 558 (13.3%) received neoadjuvant chemotherapy, and 392 (9.3%) received chemotherapy for metastatic disease...
March 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/28415509/preparation-and-evaluation-of-a-novel-anticancer-drug-delivery-carrier-for-5-fluorouracil-using-synthetic-bola-amphiphile-based-on-lysine-as-polar-heads
#13
Beibei Hu, Yue Yuan, Yun Yan, Xiaoping Zhou, Yue Li, Qiming Kan, Sanming Li
A novel bolaamphiphile surfactant N,N'-(dodecane-1, 12-diyl) bis (2,6-diaminohexanamide) (DADL) was designed and synthesized using l-lysine and 1,12-diaminododecane as the hydrophilic and hydrophobic part, respectively. After separation and purification, the structure of the synthetic bolaamphiphile surfactant was verified by FTIR, MS and (1)H NMR. The synthetic bolaamphiphile was able to self-assemble to form vesicles. After formulation screening, vesicles loaded with 5-Fluorouracil (5-Fu) were prepared with Tween 60 and DADL by sonication and were examined by dynamic light scattering and transmission electron microscopy...
June 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28415431/in-vitro-cytotoxicity-study-of-dual-drug-loaded-chitosan-palladium-nanocomposite-towards-ht-29-cancer-cells
#14
S Dhanavel, E A K Nivethaa, V Narayanan, A Stephen
Conjugated drug delivery has gained immense interest due to the possibility of overcoming the resistance of cancer cells to a specific drug when treated using it for a period of time. In the present study, CS/Pd nanocomposite has been prepared using cost effective chemical reduction method and has been used for the delivery of curcumin (CUR) and 5-Fluorouracil (5-FU) separately and in a conjugated form. The prepared nanocomposite before and after drug encapsulation have been studied using various characterization techniques...
June 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28415406/pcl-foamed-scaffolds-loaded-with-5-fluorouracil-anti-cancer-drug-prepared-by-an-eco-friendly-route
#15
Aurelio Salerno, Concepción Domingo, Javier Saurina
This study describes a new preparation method, which combines freeze drying and supercritical CO2 foaming approaches, for the preparation of drug delivery scaffolds of polycaprolactone loaded with 5-fluorouracil, an anti-cancer drug, with low solubility in scCO2. It is a principal objective of this work to design a scCO2 strategy to reduce 5-Fu solubility limitations in its homogeneous distribution into a PCL scaffold through the design of an innovative processing method. The design of this process is considered valuable for the development of clean technology in pharmacy and medicine, since most of the active agents have a null solubility in scCO2·Supercritical CO2 is used as a blowing agent to induce polymer foaming by means of the low temperature pressure quench process...
June 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28413680/seven-day-capecitabine-plus-docetaxel-and-oxaliplatin-regimen-for-the-treatment-of-advanced-gastric-cancer-a-phase-i-clinical-trial
#16
Rong Liang, Yan Lin, Yongqiang Li, Qian Li, Chunling Yuan, Xiaoli Liao, Sina Liao, Jinyan Zhang, Zhihui Liu
Docetaxel, cisplatin and 5-fluorouracil (DCF regimen) are currently applied as an effective combination treatment for various human malignancies; however, the efficacy of this regimen is impaired by severe adverse events associated with it. Therefore, better-tolerated regimens with comparable efficiency are required for patients with gastric cancer. To explore such possibilities, a phase-I clinical trial was performed to evaluate the safety and tolerability of a modified regimen replacing cisplatin and 5-fluorouracil with oxaliplatin and capecitabine, respectively (DOX program)...
April 2017: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/28413604/the-role-of-gli1-for-5-fu-resistance-in-colorectal-cancer
#17
Lining Zhang, Ruolan Song, Dongsheng Gu, Xiaoli Zhang, Beiqin Yu, Bingya Liu, Jingwu Xie
Colorectal cancer is a leading cause of cancer-related mortality worldwide, with Fluorouracil (5-FU)-based chemotherapy as the major treatment for advanced disease. Many patients with advanced colorectal cancer eventually succumb to the disease despite some patients responded initially to chemotherapy. Thus, identifying molecular mechanisms responsible for chemotherapy resistance will help design novel strategies to treat colorectal cancer. In this study, we established an acquired 5-FU resistant cell line, LoVo-R, from LoVo cells...
2017: Cell & Bioscience
https://www.readbyqxmd.com/read/28412829/egfr-expression-in-patients-with-esophageal-squamous-cell-carcinoma-and-its-association-with-pathologic-response-to-preoperative-chemoradiotherapy-a-study-in-northeastern-iran
#18
Kazem Anvari, Hamid R Sima, Mehdi Seilanian Toussi, Azam Anvari, Soodabeh Shahidsales, Bahram Memar, Seyed Amir Aledavoud, Mohammad N Forghani, Abbas Abdollahi, Kamran Ghaffarzadegan
INTRODUCTION: Esophageal squamous cell carcinoma (ESCC) accounts for 80% of all esophageal cancers worldwide. It is the most common histological type of esophageal carcinoma in low-resource countries. ESCC is prevalent in Asian countries, accounting for more than 95% of esophageal cancers. The epidermal growth factor receptor (EGFR) is involved in cancer development, as its gene is often mutated and/or amplified in cancer cells. According to recent statistics, esophageal cancer is the eighth most common cancer in Iran...
April 2017: Archives of Iranian Medicine
https://www.readbyqxmd.com/read/28412738/reduced-nov-expression-correlates-with-disease-progression-in-colorectal-cancer-and-is-associated-with-survival-invasion-and-chemoresistance-of-cancer-cells
#19
Jun Li, Lin Ye, Ping-Hui Sun, Fei Zheng, Fiona Ruge, Lucy K Satherley, Yi Feng, Huishan Zhao, Guifang Du, Tingting Wang, Yao Yang, Xuemei Ma, Shan Cheng, Xiaomei Yang, Hefen Yu, Xu Teng, Yang Si, Zhongtao Zhang, Wen G Jiang
Aberrant expression of nephroblastoma overexpressed (NOV) has been evident in certain malignancies. In the current study, we aim to investigate the role played by NOV in colorectal cancer (CRC). NOV expression was determined in a cohort of 359 CRC tissues and 174 normal colorectal tissues. Its impact on CRC cells was investigated using in vitro NOV knockdown and overexpression models. NOV transcripts were reduced in the CRC tumours compared with the paired adjacent normal colorectal tissues (p < 0.01) and was associated with distant metastases...
February 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/28412590/baseline-carcinoembryonic-antigen-as-a-predictive-factor-of-ramucirumab-efficacy-in-raise-a-second-line-metastatic-colorectal-carcinoma-phase-iii-trial
#20
Takayuki Yoshino, Radka Obermannová, György Bodoky, Rocio Garcia-Carbonero, Tudor Ciuleanu, David C Portnoy, Tae Won Kim, Yanzhi Hsu, David Ferry, Federico Nasroulah, Josep Tabernero
BACKGROUND: The RAISE phase III clinical trial demonstrated that ramucirumab + (folinic acid plus 5-fluorouracil plus irinotecan) FOLFIRI significantly improved overall survival (OS) versus placebo + FOLFIRI for second-line metastatic colorectal carcinoma (mCRC) patients failing bevacizumab- and oxaliplatin-based chemotherapy (hazard ratio [HR] = 0.84, 95% CI = 0.73-0.98, P = 0.022). Post hoc analyses of RAISE patient data examined the association of carcinoembryonic antigen (CEA) subgroups with efficacy parameters...
April 13, 2017: European Journal of Cancer
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