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https://www.readbyqxmd.com/read/28537877/clinical-validation-of-genetic-variants-associated-with-in-vitro-chemotherapy-related-lymphoblastoid-cell-toxicity
#1
Peter A Fasching, Lothar Häberle, Brigitte Rack, Liang Li, Alexander Hein, Arif B Ekici, Andre Reis, Michael P Lux, Julie M Cunningham, Matthias Ruebner, Gergory Jenkins, Brooke Fridley, Andreas Schneeweiss, Hans Tesch, Werner Lichtenegger, Tanja Fehm, Georg Heinrich, Mahdi Rezai, Matthias W Beckmann, Wolfgang Janni, Richard M Weinshilboum, Liewei Wang
Hematotoxicity is one of the major side effects of chemotherapy. The aim of this study was to examine the association between single nucleotide polymorphisms (SNPs) and hematotoxicity in breast cancer patients in a subset of patients of the SUCCESS prospective phase III chemotherapy study. All patients (n = 1678) received three cycles of 5-fluorouracil, epirubicin, and cyclophosphamide (FEC) followed by three cycles of docetaxel or docetaxel/gemcitabine, depending on randomization. Germline DNA was genotyped for 246 SNPs selected from a previous genome-wide association study (GWAS) in a panel of lymphoblastoid cell lines, with gemcitabine toxicity as the phenotype...
May 9, 2017: Oncotarget
https://www.readbyqxmd.com/read/28535657/-safety-and-efficacy-of-infusional-fluorouracil-leucovorin-oxaliplatin-and-irinotecan-folfoxiri-in-chinese-patients-with-advanced-colorectal-cancer
#2
Y Song, W W Li, J Huang
Objective: To establish the maximum tolerated dose (MTD) of 5-fluorouracil, leucovorin, oxaliplatin and irinotecan (FOLFOXIRI), and to evaluate the safety and efficacy in Chinese patients with advanced colorectal cancer. Methods: Patients were treated with a regimen consisting of infusional 5-fluorouracil (2 400 mg/m(2) on day 1), leucovorin (200 mg/m(2) on day 1), oxaliplatin (85 mg/m(2) on day 1), and irinotecan (at doses from 150 to 180 mg/m(2) on day 8) according to the dose-escalation schema. Treatment was repeated every 14 days...
May 23, 2017: Zhonghua Zhong Liu za Zhi [Chinese Journal of Oncology]
https://www.readbyqxmd.com/read/28535007/protective-effect-of-salvia-miltiorrhiza-bunge-on-5-fluorouracil-induced-oral-mucositis
#3
Do Rim Kim, Jinsung Kim, Ja Young Oh, Ha Young Kim, Young Joo Kim, Mun Seog Chang
Oral mucositis is a common side-effect caused by chemotherapy or radiotherapy occurring in the majority of cancer patients and is characterized by inflammation and ulcers in the oral mucosa. In the present study, we examined the protective effects of Salvia miltiorrhiza Bunge (SM) on oral mucositis induced by 5-fluorouracil (5-FU) in human pharyngeal cells and golden Syrian hamsters. We investigated the proliferation and antioxidant abilities of SM using MTT, 2-diphenyl-1-picrylhydrazyl (DPPH) and reactive oxygen species (ROS) assays in vitro...
May 23, 2017: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/28533490/is-folfoxiri-alone-or-combined-with-targeted-therapy-administered-as-first-line-treatment-a-reasonable-choice-for-most-patients-with-mcrc-systematic-review-and-network-meta-analysis
#4
Mingyi Zhou, Ping Yu, Dengue Bilibili Hernick Davin, Yanrong Li, Yuanhe Wang, Lingyu Fu, Jingdong Zhang
Whether the intensive administration of folinic acid, 5-fluorouracil, oxaliplatin and irinotecan (FOLFOXIRI) alone or combined with target therapy as first-line treatment could improve the prognosis of metastatic colorectal cancer (mCRC) patients is controversial. PubMed, the Cochrane Collaboration Central Register of Controlled Clinical Trials, Cochrane Systematic Reviews, ClinicalTrials.gov, the databases of conferences were queried to identify RCTs evaluating the efficacies and toxicities of intensive therapies used for first-line treatment of mCRC patients...
May 9, 2017: Oncotarget
https://www.readbyqxmd.com/read/28533437/metformin-inhibits-cellular-proliferation-and-bioenergetics-in-colorectal-cancer-patient-derived-xenografts
#5
Nur-Afidah Mohamed Suhaimi, Wai Min Phyo, Hao Yun Yap, Sharon Heng Yee Choy, Xiaona Wei, Yukti Choudhury, Wai Jin Tan, Luke Anthony Peng Yee Tan, Roger Sik Yin Foo, Suzanne Hui San Tan, Zenia Tiang, Chin Fong Wong, Poh Koon Koh, Min-Han Tan
There is increasing pre-clinical evidence suggesting that metformin, an anti-diabetic drug, has anti-cancer properties against various malignancies including colorectal cancer (CRC). However, majority of evidence which were derived from cancer cell lines and xenografts are likely to overestimate the benefit of metformin since these models are inadequate and require supraphysiological levels of metformin. Here, we generated patient-derived xenografts (PDX) lines from 2 CRC patients to assess the properties of metformin and 5-fluorouracil (5-FU), the first-line drug treatment for CRC...
May 22, 2017: Molecular Cancer Therapeutics
https://www.readbyqxmd.com/read/28532759/5-fluorouracil-for-actinic-keratosis-treatment-and-chemoprevention-a-randomized-controlled-trial
#6
Joanna L Walker, Julia A Siegel, Moniyka Sachar, Hyemin Pomerantz, Suephy C Chen, Susan M Swetter, Robert P Dellavalle, George P Stricklin, Abrar A Qureshi, John J DiGiovanna, Martin A Weinstock
No abstract text is available yet for this article.
June 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/28531991/multifunctional-polymer-drug-loading-system-with-ph-sensitive-fluorescent-and-targeting-property
#7
Xuening Fei, Shubei Li, Lingyun Cao, Baolian Zhang, Miaozhuo Yu
IA multifunctional drug loading system with pH-sensitive, fluorescent and targeting property was fabricated. Firstly, the amphipathic N-octyl-N'-(2-carboxyl-cyclohexamethenyl) chitosan (OCCC) was prepared by grafting hydrophobic octyl group and hydrophilic hexahydrophthalic anhydride onto chitosan, then it was modified with folic acid (FA) and thiazole orange (TO) using polyethylene glycol (PEG) as the link to fabricate a multifunctional drug loading system TO-PEG-OCCC-PEG-FA. Its chemical structure was determined by Fourier transform infrared spectroscopy (FT-IR), elemental analysis, differential scanning calorimetry (DSC) analysis, UV-vis and fluorescence spectrometer, and the results showed that the substitution degree of hydrophobic/hydrophilic group onto chitosan were 41...
August 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28531805/troxerutin-txn-potentiated-5-fluorouracil-5-fu-treatment-of-human-gastric-cancer-through-suppressing-stat3-nf-%C3%AE%C2%BAb-and-bcl-2-signaling-pathways
#8
Gui-Yun Xu, Xiao-Jun Tang
Gastric cancer still presents a significant problem for public health worldwide. Troxerutin (TXN), a flavonoid present in tea, coffee, cereal grains, and a variety of fruits and vegetables, exhibits various pharmacological and biological activities in vitro and in vivo. We investigated the ability of TXN to reverse the in vitro and in vivo drug resistance of human gastric cancer cells, which were resistant to treatment of 5-Fluorouracil (5-FU). 5-Fu is a pyrimidine analog, which is widely used in the treatment of cancers...
May 19, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28530706/akt-is-indispensable-for-coordinating-par-4-jnk-cross-talk-in-p21-downmodulation-during-er-stress
#9
R U Rasool, D Nayak, S Chakraborty, M M Faheem, B Rah, P Mahajan, V Gopinath, A Katoch, Z Iqra, S K Yousuf, D Mukherjee, L D Kumar, A Nargotra, A Goswami
The double-edged role of p21 to command survival and apoptosis is emerging. The current investigation highlights ER stress-mediated JNK activation that plausibly triggers cell death by attenuating endogenous p21 level. Here, we demonstrated that ER stress activator 3-AWA diminishes the p21 levels in cancer cells by averting the senescent phenotype to commence G2/M arrest. In essence, the deceleration in p21 level occurs through ER stress/JNK/Caspase-3 axis via activation/induction of proapoptotic Par-4 and inhibition of AKT...
May 22, 2017: Oncogenesis
https://www.readbyqxmd.com/read/28529750/phase-i-study-of-weekly-palliative-chemotherapy-with-low-dose-third-line-paclitaxel-for-biliary-tract-cancer
#10
Hidehiro Tajima, Tetsuo Ohta, Hiroyuki Shinbashi, Atsushi Hirose, Mitsuyoshi Okazaki, Takahisa Yamaguchi, Yoshinao Ohbatake, Koichi Okamoto, Shinichi Nakanuma, Seisho Sakai, Jun Kinoshita, Isamu Makino, Keishi Nakamura, Hironori Hayashi, Katsunobu Oyama, Masafumi Inokuchi, Tomoharu Miyashita, Hiroyuki Takamura, Itasu Ninomiya, Sachio Fushida, Hiroyuki Nakamura
The prognosis of patients with unresectable and recurrent biliary tract cancer (BTC) is very poor. Although gemcitabine (GEM) plus cisplatin therapy is useful for unresectable cases, the median overall survival (OS) of the patients is <1 year, and third-line chemotherapy following failure of 5-fluorouracil (5-FU) and GEM plus cisplatin is currently unavailable. The clinical efficacy and basic effects of low-dose paclitaxel (PTX) therapy for patients with BTC was previously reported. We herein present the results of a phase I clinical trial of weekly low-dose PTX as third-line palliative chemotherapy...
May 2017: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/28529594/an-active-molecule-from-pulsatilla-chinensis-pulsatilla-saponin-a-induces-apoptosis-and-inhibits-tumor-growth-of-human-colon-cancer-cells-without-or-with-5-fu
#11
Liming Xu, Guilian Cheng, Yi Lu, Shaofeng Wang
Colon cancer is one of the common types of digestive malignancy. The efficacy of the first-line chemotherapy drug for colon cancer, fluorouracil (5-FU), remains limited in clinical settings due to poor efficacy and significant side effects. In the present study, the anticancer activity of an active compound from Pulsatilla chinensis extracts, Pulsatilla saponin A (PsA), was isolated and examined in vitro and in vivo. It was demonstrated that PsA significantly inhibited the growth of human colon cancer HT-29 cells...
May 2017: Oncology Letters
https://www.readbyqxmd.com/read/28526879/musashi-1-promotes-a-cancer-stem-cell-lineage-and-chemoresistance-in-colorectal-cancer-cells
#12
Guang-Yuh Chiou, Tzu-Wei Yang, Chi-Chou Huang, Chia-Ying Tang, Jung-Yi Yen, Ming-Chang Tsai, Hsuan-Yi Chen, Nurul Fadhilah, Chun-Che Lin, Yuh-Jyh Jong
Colorectal cancers (CRCs) are a critical health issue worldwide. Cancer stem cell (CSC) lineages are associated with tumour transformation, progression, and malignant transformation. However, how lineages are transformed and how chemoresistance is acquired by CRCs remain largely unknown. In this report, we demonstrated that the RNA-binding protein Musashi-1 enhanced the development of CD44(+) colorectal CSCs and triggered the formation of anti-apoptotic stress granules (SGs). Our results indicated that CD44(+) CSC lineage-specific induction of tumour malignancies was controlled by Musashi-1...
May 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28526342/ph-controlled-drug-delivery-with-hybrid-aerogel-of-chitosan-carboxymethyl-cellulose-and-graphene-oxide-as-the-carrier
#13
Ren Wang, Dan Shou, Ouyang Lv, Yong Kong, Linhong Deng, Jian Shen
Hybrid aerogels of chitosan (CS), carboxymethyl cellulose (CMC) and graphene oxide (GO) are successfully prepared by using calcium ion (Ca(2+)) as the crosslinker. The resultant hybrid aerogels, CS/CMC/Ca(2+)/GO, are characterized by field emission scanning electron microscopy (FESEM) and Fourier transform infrared (FT-IR) spectroscopy. Due to the pH sensitivity of CS and CMC, pH-controlled drug delivery with CS/CMC/Ca(2+)/GO as the carrier is investigated using 5-fluorouracil (5-FU), an effective chemotherapeutic agent in the treatment of cancers, as the model drug...
May 16, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28525845/novel-amidino-substituted-benzimidazole-and-benzothiazole-benzo-b-thieno-2-carboxamides-exert-strong-antiproliferative-and-dna-binding-properties
#14
Maja Cindrić, Samy Jambon, Anja Harej, Sabine Depauw, Marie-Hélène David-Cordonnier, Sandra Kraljević Pavelić, Grace Karminski-Zamola, Marijana Hranjec
Within this manuscript design, synthesis of novel 2-imidazolinyl substituted benzo[b]thieno-2-carboxamides bearing either benzimidazole or benzothiazole subunit and biological activity are presented and described. The antiproliferative activities were assessed in vitro on a panel of human cancer cell lines. Tested compounds showed moderate activity while cytotoxicity on normal fibroblasts was lower in comparison with 5-fluorouracile. The variations of 2-imidazolinyl substituent at heteroaromatic subunits in different positions led to different cytotoxic properties...
May 4, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28525328/establishment-of-5-fluorouracil-resistant-canine-mammary-tumor-cell-line
#15
B Zhou, D Zhang, S M Pei, H Zhang, H C Du, Y P Jin, D G Lin
Canine mammary tumors are the most common neoplasms in intact female dogs. The surgery cannot always solve the problem, chemotherapy are recommend to these patients. However, chemotherapy could always fail because of multidrug resistance (MDR). Through stepwise increasing 5-Fluorouracil (5-FU) concentration in the culture medium, a 5-FU-resistant canine mammary tumor cell line CMT7364/5-FU was established to disclose the molecular mechanism of the drug resistance. Cell morphology, cell sensitivity to drugs, growth curves, expression of proteins, and chemo-sensitivity in vivo were compared between the parental cell line and resistant cell line...
March 28, 2017: Polish Journal of Veterinary Sciences
https://www.readbyqxmd.com/read/28521972/coronary-vasospasm-associated-with-5-fluorouracil-chemotherapy-cardiac-toxicity-or-cardiac-hypersensitivity
#16
Nicholas G Kounis, Ioanna Koniari, Nicholas Patsouras, Nicholas Koutsogiannis, Dimitrios Velissaris, George Soufras, George Hahalis
No abstract text is available yet for this article.
May 12, 2017: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/28521444/microrna-330-inhibited-cell-proliferation-and-enhanced-chemosensitivity-to-5-fluorouracil-in-colorectal-cancer-by-directly-targeting-thymidylate-synthase
#17
Weidong Xu, Huayong Jiang, Fuli Zhang, Junmao Gao, Jun Hou
Colorectal cancer (CRC) is the third most common cancer in males and the second most common in females, worldwide. Currently, 5-fluorouracil (5-FU)-mediated chemotherapy is the adjuvant treatment for patients with CRC following surgical resection. However, a number of patients with CRC develop 5-FU resistance, which is a major challenge for the effective treatment of cancer. Therefore, it is important to investigate the molecular mechanisms underlying chemoresistance and the therapeutic treatments that may improve the treatment of CRC...
May 2017: Oncology Letters
https://www.readbyqxmd.com/read/28520529/synthesis-of-theranostic-epithelial-cell-adhesion-molecule-targeted-mesoporous-silica-nanoparticle-with-gold-gatekeeper-for-hepatocellular-carcinoma
#18
Maryam Babaei, Khalil Abnous, Seyed Mohammad Taghdisi, Sara Amel Farzad, Mohammad Taghi Peivandi, Mohammad Ramezani, Mona Alibolandi
AIM: In this study, we report the fabrication of epithelial cell adhesion molecule targeted 5-fluorouracil (5-FU) encapsulated PEGylated mesoporous silica nanoparticles (NPs) hybridized with gold NPs (PEG-Au@Si-5-FU) as gatekeeper for theranostic applications. MATERIALS & METHODS: The prepared targeted and nontargeted formulations were evaluated in vitro in terms of their cellular internalization and toxicity. The prepared theranostic hybrid system was also implemented for computed tomography of HepG2 tumor-bearing nude mice in vivo...
May 18, 2017: Nanomedicine
https://www.readbyqxmd.com/read/28517004/exploitation-of-new-structurally-diverse-d-glucuronamide-containing-n-glycosyl-compounds-synthesis-and-anticancer-potential
#19
Nuno M Xavier, Alexandre Porcheron, Daniela Batista, Radek Jorda, Eva Řezníčková, Vladimír Kryštof, M Conceição Oliveira
The synthesis and anticancer evaluation of novel N-glycosyl derivatives containing N-substituted glucuronamide moieties, as nucleoside analogs or as prospective mimetics of glycosyl phosphates or of nucleotides, is reported. These compounds comprise N-anomerically-linked nucleobases or motifs that are surrogates of a phosphate group, such as sulfonamide or phosphoramidate moieties. 1-Sulfonamido glucuronamides containing N-benzyl, N-propargyl or N-dodecyl carboxamide units were synthesized through glycosylation of methanesulfonamide with tetra-O-acetyl glucuronamides...
May 18, 2017: Organic & Biomolecular Chemistry
https://www.readbyqxmd.com/read/28515931/pharmaco-economic-analysis-of-adjuvant-chemotherapy-for-stage-ii-and-iii-colorectal-cancer
#20
Mina Iwai, Michio Kimura, Eiseki Usami, Tomoaki Yoshimura, Hitomi Teramachi
Comparison of the costs of capecitabine plus oxaliplatin (CapeOX) with that of FOLFOX6 (5-fluorouracil/leucovorin [LV] + oxaliplatin) as an adjuvant chemotherapy for stage II or III colorectal cancer has previously been reported. However, there are no reports comparing uracil and tegafur (UFT)/LV with capecitabine. Therefore, the current study compared the costs of adjuvant chemotherapy regimens including CapeOX, FOLFOX6, capecitabine and UFT/LV. The costs of chemotherapeutic drugs and for the prevention and treatment of adverse events were evaluated, as these account for the bulk of the treatment costs...
May 2017: Molecular and Clinical Oncology
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