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https://www.readbyqxmd.com/read/29670349/fabrication-of-a-triptolide-loaded-and-poly-%C3%AE-glutamic-acid-based-amphiphilic-nanoparticle-for-the-treatment-of-rheumatoid-arthritis
#1
Li Zhang, Junli Chang, Yongjian Zhao, Hao Xu, Tengteng Wang, Qiang Li, Lianping Xing, Jing Huang, Yongjun Wang, Qianqian Liang
Triptolide (TP) exhibits immunosuppressive, cartilage-protective and anti-inflammatory effects in rheumatoid arthritis. However, the toxicity of TP limits its widespread use. To decrease the toxic effects, we developed a novel nano-drug carrier system containing TP using poly-γ-glutamic acid-grafted di-tert-butyl L-aspartate hydrochloride (PAT). PAT had an average diameter of 79±18 nm, a narrow polydispersity index (0.18), a strong zeta potential (-32 mV) and a high drug encapsulation efficiency (EE1 =48...
2018: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/29577119/apoptosis-effects-of-imperatorin-on-synoviocytes-in-rheumatoid-arthritis-through-mitochondrial-caspase-mediated-pathways
#2
Ke-Feng Zhai, Hong Duan, Yuan Chen, Ghulam Jilany Khan, Wen-Gen Cao, Gui-Zhen Gao, Ling-Ling Shan, Zhao-Jun Wei
Rheumatoid arthritis (RA) is a systemic chronic inflammatory disease associated with a potential imbalance between the growth and death of rheumatoid arthritis fibroblast-like synoviocytes (RA-FLSs). Imperatorin (IPT) is a naturally occurring furanocoumarin found in umbelliferous vegetables, citrus fruits, and some herbs. The effects of IPT on the proliferation and apoptosis of RA-FLSs and its potential underlying mechanisms have remained unclear. RA-FLSs obtained from RA patients were induced by interleukin-1β (IL-1β) and treated with IPT...
March 26, 2018: Food & Function
https://www.readbyqxmd.com/read/28982129/the-tyrosine-kinase-inhibitor-imatinib-mesylate-suppresses-uric-acid-crystal-induced-acute-gouty-arthritis-in-mice
#3
Laurent L Reber, Philipp Starkl, Bianca Balbino, Riccardo Sibilano, Nicolas Gaudenzio, Stephan Rogalla, Steven Sensarn, Dongmin Kang, Harini Raghu, Jeremy Sokolove, William H Robinson, Christopher H Contag, Mindy Tsai, Stephen J Galli
Gouty arthritis is caused by the deposition of monosodium urate (MSU) crystals in joints. Despite many treatment options for gout, there is a substantial need for alternative treatments for patients unresponsive to current therapies. Tyrosine kinase inhibitors have demonstrated therapeutic benefit in experimental models of antibody-dependent arthritis and in rheumatoid arthritis in humans, but to date, the potential effects of such inhibitors on gouty arthritis has not been evaluated. Here we demonstrate that treatment with the tyrosine kinase inhibitor imatinib mesylate (imatinib) can suppress inflammation induced by injection of MSU crystals into subcutaneous air pouches or into the ankle joint of wild type mice...
2017: PloS One
https://www.readbyqxmd.com/read/28867530/clinical-and-microbiological-profile-of-diabetic-foot-ulcer-patients-in-a-tertiary-care-hospital
#4
Ramya Kateel, Alfred J Augustine, Shivananda Prabhu, Sheetal Ullal, Manohar Pai, Prabha Adhikari
AIM: To evaluate the clinical and microbiological profile of diabetic foot ulcer patients admitted to a tertiary care hospital. METHODOLOGY: This study recruited 120 diabetic foot ulcer patients of all grade. Their medical records were evaluated retrospectively. RESULTS: We found that median age of patient was 60(52, 67.75) years. 68.3% of patients were males. Median duration of diabetes mellitus was 15(10, 20) years. Mean HbA1C and fasting glucose was 10...
January 2018: Diabetes & Metabolic Syndrome
https://www.readbyqxmd.com/read/28463782/asymptomatic-polyvascular-disease-and-the-risks-of-cardiovascular-events-and-all-cause-death
#5
Qian Zhang, Anxin Wang, Shufeng Zhang, Na Li, Shengyun Chen, Yaqing Zhang, Yong Zhou, Shouling Wu, Xingquan Zhao
BACKGROUND AND AIMS: Atherosclerosis is a diffuse and systemic disease. We aimed to assess prevalence and outcome of extracoronary polyvascular disease (polyVD) in the asymptomatic Chinese community population. METHODS: A random sample of 5440 participants aged 40 years or older were enrolled in the Asymptomatic Polyvascular Abnormalities Community Study from 2010 to 2011. Intracranial artery stenosis, extracranial artery stenosis, and lower extremity artery disease were detected by transcranial Doppler and duplex sonography, and by calculating the ankle brachial index...
April 21, 2017: Atherosclerosis
https://www.readbyqxmd.com/read/28149336/transferability-between-isolated-joint-torques-and-a-maximum-polyarticular-task-a-preliminary-study
#6
Antony Costes, David Villeger, Pierre Moretto, Bruno Watier
The aims of this study were to determine if isolated maximum joint torques and joint torques during a maximum polyarticular task (i.e. cycling at maximum power) are correlated despite joint angle and velocity discrepancies, and to assess if an isolated joint-specific torque production capability at slow angular velocity is related to cycling power. Nine cyclists completed two different evaluations of their lower limb maximum joint torques. Maximum Isolated Torques were assessed on isolated joint movements using an isokinetic ergometer and Maximum Pedalling Torques were calculated at the ankle, knee and hip for flexion and extension by inverse dynamics during cycling at maximum power...
April 1, 2016: Journal of Human Kinetics
https://www.readbyqxmd.com/read/27282601/bioresorbable-everolimus-eluting-vascular-scaffold-for-patients-with-peripheral-artery-disease-esprit-i-2-year-clinical-and-imaging-results
#7
MULTICENTER STUDY
Johannes Lammer, Marc Bosiers, Koen Deloose, Andrej Schmidt, Thomas Zeller, Florian Wolf, Wouter Lansink, Antoine Sauguet, Frank Vermassen, Geert Lauwers, Dierk Scheinert, Jeffrey J Popma, Robert McGreevy, Richard Rapoza, Lewis B Schwartz, Michael R Jaff
OBJECTIVES: This is the first-in-human study of a drug-eluting bioresorbable vascular scaffold (BVS) for treatment of peripheral artery disease (PAD) involving the external iliac artery (EIA) and superficial femoral artery (SFA). BACKGROUND: Drug-eluting BVS has shown promise in coronary arteries. METHODS: The ESPRIT BVS system is a device-drug combination consisting of an everolimus-eluting poly-l-lactide scaffold. Safety and performance were evaluated in 35 subjects with symptomatic claudication...
June 13, 2016: JACC. Cardiovascular Interventions
https://www.readbyqxmd.com/read/27171651/direct-electrospinning-of-3d-auricle-shaped-scaffolds-for-tissue-engineering-applications
#8
Jochen Walser, Kathryn S Stok, Marco D Caversaccio, Stephen J Ferguson
Thirty-two poly(ε)caprolactone (PCL) scaffolds have been produced by electrospinning directly into an auricle-shaped mould and seeded with articular chondrocytes harvested from bovine ankle joints. After seeding, the auricle shaped constructs were cultured in vitro and analysed at days 1, 7, 14 and 21 for regional differences in total DNA, glycosaminoglycan (GAG) and collagen (COL) content as well as the expression of aggrecan (AGG), collagen type I and type II (COL1/2) and matrix metalloproteinase 3 and 13 (MMP3/13)...
May 12, 2016: Biofabrication
https://www.readbyqxmd.com/read/25964048/stealth-nanogels-of-histinylated-poly-ethyleneimine-for-sustained-delivery-of-methotrexate-in-collagen-induced-arthritis-model
#9
SamiraSadat Abolmaali, AliMohammad Tamaddon, Eskandar Kamali-Sarvestani, MohammadJavad Ashraf, Rasoul Dinarvand
PURPOSE: The study aimed to illustrate application of polycation Stealth nanogels for sustained delivery of methotrexate (MTX) in collagen induced arthritis (CIA) model in C57Bl/6 mice. METHODS: Nanogel synthesis involves metal ion coordinated self-assembly of PEGylated poly ethyleneimine (L-histidine substituted), chemical crosslinking and subsequent removal of the coordinated metal. The nanogels were characterized by TEM and DLS-zeta potential. Comparative efficacy and pharmacokinetics of the i...
October 2015: Pharmaceutical Research
https://www.readbyqxmd.com/read/25709538/radiosynovectomy-in-the-therapeutic-management-of-arthritis
#10
REVIEW
Liepe Knut
Radiosynovectomy is a well-established therapy in arthritis and involves an intra-articular injection of small radioactive particles to treat a synovitis. In Europe, frequent indications are rheumatoid and poly-arthritis. Especially in Germany radiosynovectomy is the second common therapy in Nuclear Medicine with about 40,000-60,000 treated joints per year. In Spain, USA, Turkey, Argentines and Philippines the therapy is more use in hemophilic arthritis with excellent results. Especially in developing countries with low availability of clotting factors, the radiosynovectomy represent a cost effective therapeutic option for repeated bleedings in hemophilic arthropathy...
January 2015: World Journal of Nuclear Medicine
https://www.readbyqxmd.com/read/25297275/p7-003%C3%A3-%C3%A3-mesenchymal-stem-cells-in-combination-with-nano-fiber-scaffold-suppressed-arthritis-in-rats
#11
(no author information available yet)
【Objectives】 Mesenchymal stem cells (MSC) possess immunoregulatory ability with osteoblastogenesis which makes them an ideal tool for arthritis treatment. Here we utilized nano-fiber poly-lactic-co-glycolic acid as a scaffold to deliver MSC into arthritic models. 【Methods】 MSC were injected intra-articularly (IA) or intra-peritoneally (IP) or seeded on nano-fiber and implanted into ankles (nano-MSC) of collagen induced arthritis (CIA) rats. 【Results】 Arthritis and bone destruction were significantly suppressed by nano-MSC treatment, while IA or IP demonstrated no effects...
2014: Nihon Rinshō Men'eki Gakkai Kaishi, Japanese Journal of Clinical Immunology
https://www.readbyqxmd.com/read/25292418/contemporary-outcomes-with-percutaneous-vascular-interventions-for-peripheral-critical-limb-ischemia-in-those-with-and-without-poly-vascular-disease
#12
MULTICENTER STUDY
Venkat Krishnamurthy, Kahn Munir, John E Rectenwald, Ash Mansour, Sachinder Hans, Jonathan L Eliason, Guillermo A Escobar, Katherine A Gallagher, Paul M Grossman, Hitinder S Gurm, Dave A Share, Peter K Henke
Given the very ill nature of patients with critical limb ischemia (CLI), the use of percutaneous vascular interventions (PVIs) for limb salvage may or may not be efficacious; in particular, for those with polyvascular arterial disease. Herein, we reviewed large, multi-institutional outcomes of PVI in polyvascular and peripheral arterial disease (PAD) patients with CLI. An 18-hospital consortium collected prospective data on patients undergoing endovascular interventions for PAD with 6-month follow-up from January 2008 to December 2011...
December 2014: Vascular Medicine
https://www.readbyqxmd.com/read/25052528/lyme-arthritis-of-the-pediatric-lower-extremity-in-the-setting-of-polyarticular-disease
#13
Amiethab Aiyer, William Hennrikus, Jessica Walrath, Brandt Groh, Barbara Ostrov
BACKGROUND: Lyme arthritis can be readily treated with use of oral antibiotics without any need for surgery. In Lyme-endemic areas, differentiating between Lyme arthritis and septic arthritis can be difficult. Laboratory testing for Lyme disease often results in a delay in diagnosis because many labs batch-test Lyme specimens only two times per week due to lack of equipment or increased expense. Delayed diagnosis can lead to unneeded surgery in cases in which the surgeon indicates the patient for a joint irrigation and debridement (I & D) for possible septic arthritis while waiting for Lyme serology results...
August 2014: Journal of Children's Orthopaedics
https://www.readbyqxmd.com/read/24990547/medication-prescription-and-adherence-disparities-in-non-valvular-atrial-fibrillation-patients-an-italian-portrait-from-the-arapacis-study
#14
Valeria Raparelli, Marco Proietti, Carmelo Buttà, Paolo Di Giosia, Domenico Sirico, Paolo Gobbi, Salvatore Corrao, Giovanni Davì, Anna Rita Vestri, Francesco Perticone, Gino Roberto Corazza, Francesco Violi, Stefania Basili
Non-valvular atrial fibrillation (NVAF) represents a major health-care problem, needing an extensive and strict thrombosis prevention for stroke and cardiovascular (CV) disease risks. NVAF management guidelines recommend adequate antithrombotic and anti-atherosclerotic therapies. Medication adherence has been recognized as a pivotal element in health quality promotion and in the achievement of better clinical outcomes. We conducted a post-hoc analysis of the "Atrial fibrillation Registry for Ankle-brachial index Prevalence Assessment-Collaborative Italian Study (ARAPACIS)" with the aim of discerning differences in pharmacological management and medication adherence among NVAF Italian patients...
December 2014: Internal and Emergency Medicine
https://www.readbyqxmd.com/read/24529932/evaluation-of-the-biodegradable-peripheral-igaki-tamai-stent-in-the-treatment-of-de-novo-lesions-in-the-superficial-femoral-artery-the-gaia-study
#15
MULTICENTER STUDY
Martin Werner, Antonio Micari, Angelo Cioppa, Giuseppe Vadalà, Andrej Schmidt, Horst Sievert, Paolo Rubino, Annalisa Angelini, Dierk Scheinert, Giancarlo Biamino
OBJECTIVES: This study sought to evaluate the safety and performance of the Igaki-Tamai (Igaki Medical Planning Company, Kyoto, Japan) biodegradable stent in patients with occlusive superficial femoral artery (SFA) disease. BACKGROUND: Poly-L-lactic acid (PLLA) biodegradable stents have been shown to be effective in the coronaries, but no data are available regarding their efficacy in the femoral artery. METHODS: A prospective, multicenter, nonrandomized study enrolled 30 patients with symptomatic de novo SFA disease undergoing implantation of Igaki-Tamai bioresorbable stents...
March 2014: JACC. Cardiovascular Interventions
https://www.readbyqxmd.com/read/24172482/p6-06%C3%A2-%C3%A2-mesenchymal-stem-cells-as-an-ideal-cell-therapy-tool-for-rheumatoid-arthritis-in-combination-with-nano-fiber-scaffold
#16
(no author information available yet)
Mesenchymal stem cells (MSCs) possess immunoregulatory ability with multipotency which makes this cells an ideal tool for treatment of rheumatoid arthritis (RA). Aiming clinical use, the effect of MSCs combined with nano-fiber poly-lactic-co-glycollic acid sheet scaffold (nano-sheet) was assessed. MSCs were injected intra-articularly (IA) or intra-peritoneally (IP) or seeded on nano-sheet and implanted into ankles (IMP) of collagen induced arthritis (CIA) rats. IA or IP treatment demonstrated no effects whereas, IMP significantly suppressed arthritis evaluated by arthritis score and body weight...
2013: Nihon Rinshō Men'eki Gakkai Kaishi, Japanese Journal of Clinical Immunology
https://www.readbyqxmd.com/read/23812439/minimum-thickness-of-all-poly-tibial-component-unicompartmental-knee-arthroplasty-in-patients-younger-than-60-years-does-not-increase-revision-rate-for-aseptic-loosening
#17
Danilo Bruni, Ibrahim Akkawi, Francesco Iacono, Giovanni Francesco Raspugli, Michele Gagliardi, Marco Nitri, Alberto Grassi, Stefano Zaffagnini, Simone Bignozzi, Maurilio Marcacci
PURPOSE: Management of unicompartmental knee osteoarthritis in middle-aged patients is a challenging problem. Despite its functional advantages, UKA still raises questions concerning implant survivorship and an increased revision risk for aseptic loosening mainly due to polyethylene wear. The main purpose of the present study was to investigate whether using the minimum thickness of an all-poly tibial UKA in patients under 60 years of age increases the revision rate for aseptic loosening...
November 2013: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
https://www.readbyqxmd.com/read/23520296/chevron-osteotomy-of-the-first-metatarsal-stabilized-with-an-absorbable-pin-our-5-year-experience
#18
Alberto Morandi, Emanuele Ungaro, Andrea Fraccia, Valerio Sansone
BACKGROUND: The potential requirement for hardware removal originally fueled the development of bioabsorbable pins as an alternative to metal screws for fixing osteotomy sites in foot surgery. More recently, the concern regarding the adverse effects of metal implants may provide further grounds for using bioabsorbable rather than metal fixation. METHODS: This is a prospective study of 383 consecutive patients (439 feet) who underwent a chevron osteotomy to correct a hallux valgus deformity performed between 2005 and 2010...
March 2013: Foot & Ankle International
https://www.readbyqxmd.com/read/23399887/complications-after-tendon-transfers-in-the-foot-and-ankle-using-bioabsorbable-screws
#19
Thomas O Clanton, Alex A Betech, Aaron M Bott, Lauren M Matheny, Braden Hartline, Travis W Hanson, William C McGarvey
BACKGROUND: Tendon transfers are commonly used for correction of pathology or deformity of the foot and ankle. Bioabsorbable implants have been developed as an alternative to metal interference screws. The purpose of this study was to document complications following tendon transfers of the foot and ankle using bioabsorbable poly-L-lactide interference screws. METHODS: A retrospective chart review was used to identify patients in whom either of the 2 senior authors had performed a tendon transfer of the foot and ankle using a bioabsorbable interference screw between 1999 and 2005...
April 2013: Foot & Ankle International
https://www.readbyqxmd.com/read/23384867/research-and-application-of-absorbable-screw-in-orthopedics-a-clinical-review-comparing-pdlla-screw-with-metal-screw-in-patients-with-simple-medial-malleolus-fracture
#20
COMPARATIVE STUDY
Jin Tang, Jin-feng Hu, Wei-chun Guo, Ling Yu, Sheng-hao Zhao
OBJECTIVE: To observe the therapeutic effect of absorbable screw in medial malleolus fracture and discuss its clinical application in orthopedics. METHODS: A total of 129 patients with simple medial malleolus fracture were studied. Among them, 64 patients were treated with poly-D, L-lactic acid (PDLLA) absorbable screws, while the others were treated with metal screws. All the patients were followed up for 12-20 months (averaged 18.4 months) and the therapeutic effect was evaluated according to the American Orthopaedic Foot and Ankle Society clinical rating systems...
2013: Chinese Journal of Traumatology, Zhonghua Chuang Shang za Zhi
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