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https://www.readbyqxmd.com/read/27282601/bioresorbable-everolimus-eluting-vascular%C3%A2-scaffold-for-patients-with-peripheral%C3%A2-artery-disease-esprit-i-2-year-clinical-and-imaging-results
#1
Johannes Lammer, Marc Bosiers, Koen Deloose, Andrej Schmidt, Thomas Zeller, Florian Wolf, Wouter Lansink, Antoine Sauguet, Frank Vermassen, Geert Lauwers, Dierk Scheinert, Jeffrey J Popma, Robert McGreevy, Richard Rapoza, Lewis B Schwartz, Michael R Jaff
OBJECTIVES: This is the first-in-human study of a drug-eluting bioresorbable vascular scaffold (BVS) for treatment of peripheral artery disease (PAD) involving the external iliac artery (EIA) and superficial femoral artery (SFA). BACKGROUND: Drug-eluting BVS has shown promise in coronary arteries. METHODS: The ESPRIT BVS system is a device-drug combination consisting of an everolimus-eluting poly-l-lactide scaffold. Safety and performance were evaluated in 35 subjects with symptomatic claudication...
June 13, 2016: JACC. Cardiovascular Interventions
https://www.readbyqxmd.com/read/27171651/direct-electrospinning-of-3d-auricle-shaped-scaffolds-for-tissue-engineering-applications
#2
Jochen Walser, Kathryn S Stok, Marco D Caversaccio, Stephen J Ferguson
Thirty-two poly(ε)caprolactone (PCL) scaffolds have been produced by electrospinning directly into an auricle-shaped mould and seeded with articular chondrocytes harvested from bovine ankle joints. After seeding, the auricle shaped constructs were cultured in vitro and analysed at days 1, 7, 14 and 21 for regional differences in total DNA, glycosaminoglycan (GAG) and collagen (COL) content as well as the expression of aggrecan (AGG), collagen type I and type II (COL1/2) and matrix metalloproteinase 3 and 13 (MMP3/13)...
June 2016: Biofabrication
https://www.readbyqxmd.com/read/25964048/stealth-nanogels-of-histinylated-poly-ethyleneimine-for-sustained-delivery-of-methotrexate-in-collagen-induced-arthritis-model
#3
SamiraSadat Abolmaali, AliMohammad Tamaddon, Eskandar Kamali-Sarvestani, MohammadJavad Ashraf, Rasoul Dinarvand
PURPOSE: The study aimed to illustrate application of polycation Stealth nanogels for sustained delivery of methotrexate (MTX) in collagen induced arthritis (CIA) model in C57Bl/6 mice. METHODS: Nanogel synthesis involves metal ion coordinated self-assembly of PEGylated poly ethyleneimine (L-histidine substituted), chemical crosslinking and subsequent removal of the coordinated metal. The nanogels were characterized by TEM and DLS-zeta potential. Comparative efficacy and pharmacokinetics of the i...
October 2015: Pharmaceutical Research
https://www.readbyqxmd.com/read/25709538/radiosynovectomy-in-the-therapeutic-management-of-arthritis
#4
REVIEW
Liepe Knut
Radiosynovectomy is a well-established therapy in arthritis and involves an intra-articular injection of small radioactive particles to treat a synovitis. In Europe, frequent indications are rheumatoid and poly-arthritis. Especially in Germany radiosynovectomy is the second common therapy in Nuclear Medicine with about 40,000-60,000 treated joints per year. In Spain, USA, Turkey, Argentines and Philippines the therapy is more use in hemophilic arthritis with excellent results. Especially in developing countries with low availability of clotting factors, the radiosynovectomy represent a cost effective therapeutic option for repeated bleedings in hemophilic arthropathy...
January 2015: World Journal of Nuclear Medicine
https://www.readbyqxmd.com/read/25297275/p7-003%C3%A3-%C3%A3-mesenchymal-stem-cells-in-combination-with-nano-fiber-scaffold-suppressed-arthritis-in-rats
#5
(no author information available yet)
【Objectives】 Mesenchymal stem cells (MSC) possess immunoregulatory ability with osteoblastogenesis which makes them an ideal tool for arthritis treatment. Here we utilized nano-fiber poly-lactic-co-glycolic acid as a scaffold to deliver MSC into arthritic models. 【Methods】 MSC were injected intra-articularly (IA) or intra-peritoneally (IP) or seeded on nano-fiber and implanted into ankles (nano-MSC) of collagen induced arthritis (CIA) rats. 【Results】 Arthritis and bone destruction were significantly suppressed by nano-MSC treatment, while IA or IP demonstrated no effects...
2014: Nihon Rinshō Men'eki Gakkai Kaishi, Japanese Journal of Clinical Immunology
https://www.readbyqxmd.com/read/25292418/contemporary-outcomes-with-percutaneous-vascular-interventions-for-peripheral-critical-limb-ischemia-in-those-with-and-without-poly-vascular-disease
#6
MULTICENTER STUDY
Venkat Krishnamurthy, Kahn Munir, John E Rectenwald, Ash Mansour, Sachinder Hans, Jonathan L Eliason, Guillermo A Escobar, Katherine A Gallagher, Paul M Grossman, Hitinder S Gurm, Dave A Share, Peter K Henke
Given the very ill nature of patients with critical limb ischemia (CLI), the use of percutaneous vascular interventions (PVIs) for limb salvage may or may not be efficacious; in particular, for those with polyvascular arterial disease. Herein, we reviewed large, multi-institutional outcomes of PVI in polyvascular and peripheral arterial disease (PAD) patients with CLI. An 18-hospital consortium collected prospective data on patients undergoing endovascular interventions for PAD with 6-month follow-up from January 2008 to December 2011...
December 2014: Vascular Medicine
https://www.readbyqxmd.com/read/25052528/lyme-arthritis-of-the-pediatric-lower-extremity-in-the-setting-of-polyarticular-disease
#7
Amiethab Aiyer, William Hennrikus, Jessica Walrath, Brandt Groh, Barbara Ostrov
BACKGROUND: Lyme arthritis can be readily treated with use of oral antibiotics without any need for surgery. In Lyme-endemic areas, differentiating between Lyme arthritis and septic arthritis can be difficult. Laboratory testing for Lyme disease often results in a delay in diagnosis because many labs batch-test Lyme specimens only two times per week due to lack of equipment or increased expense. Delayed diagnosis can lead to unneeded surgery in cases in which the surgeon indicates the patient for a joint irrigation and debridement (I & D) for possible septic arthritis while waiting for Lyme serology results...
August 2014: Journal of Children's Orthopaedics
https://www.readbyqxmd.com/read/24990547/medication-prescription-and-adherence-disparities-in-non-valvular-atrial-fibrillation-patients-an-italian-portrait-from-the-arapacis-study
#8
Valeria Raparelli, Marco Proietti, Carmelo Buttà, Paolo Di Giosia, Domenico Sirico, Paolo Gobbi, Salvatore Corrao, Giovanni Davì, Anna Rita Vestri, Francesco Perticone, Gino Roberto Corazza, Francesco Violi, Stefania Basili
Non-valvular atrial fibrillation (NVAF) represents a major health-care problem, needing an extensive and strict thrombosis prevention for stroke and cardiovascular (CV) disease risks. NVAF management guidelines recommend adequate antithrombotic and anti-atherosclerotic therapies. Medication adherence has been recognized as a pivotal element in health quality promotion and in the achievement of better clinical outcomes. We conducted a post-hoc analysis of the "Atrial fibrillation Registry for Ankle-brachial index Prevalence Assessment-Collaborative Italian Study (ARAPACIS)" with the aim of discerning differences in pharmacological management and medication adherence among NVAF Italian patients...
December 2014: Internal and Emergency Medicine
https://www.readbyqxmd.com/read/24529932/evaluation-of-the-biodegradable-peripheral-igaki-tamai-stent-in-the-treatment-of-de-novo-lesions-in-the-superficial-femoral-artery-the-gaia-study
#9
MULTICENTER STUDY
Martin Werner, Antonio Micari, Angelo Cioppa, Giuseppe Vadalà, Andrej Schmidt, Horst Sievert, Paolo Rubino, Annalisa Angelini, Dierk Scheinert, Giancarlo Biamino
OBJECTIVES: This study sought to evaluate the safety and performance of the Igaki-Tamai (Igaki Medical Planning Company, Kyoto, Japan) biodegradable stent in patients with occlusive superficial femoral artery (SFA) disease. BACKGROUND: Poly-L-lactic acid (PLLA) biodegradable stents have been shown to be effective in the coronaries, but no data are available regarding their efficacy in the femoral artery. METHODS: A prospective, multicenter, nonrandomized study enrolled 30 patients with symptomatic de novo SFA disease undergoing implantation of Igaki-Tamai bioresorbable stents...
March 2014: JACC. Cardiovascular Interventions
https://www.readbyqxmd.com/read/24172482/p6-06%C3%A2-%C3%A2-mesenchymal-stem-cells-as-an-ideal-cell-therapy-tool-for-rheumatoid-arthritis-in-combination-with-nano-fiber-scaffold
#10
(no author information available yet)
Mesenchymal stem cells (MSCs) possess immunoregulatory ability with multipotency which makes this cells an ideal tool for treatment of rheumatoid arthritis (RA). Aiming clinical use, the effect of MSCs combined with nano-fiber poly-lactic-co-glycollic acid sheet scaffold (nano-sheet) was assessed. MSCs were injected intra-articularly (IA) or intra-peritoneally (IP) or seeded on nano-sheet and implanted into ankles (IMP) of collagen induced arthritis (CIA) rats. IA or IP treatment demonstrated no effects whereas, IMP significantly suppressed arthritis evaluated by arthritis score and body weight...
2013: Nihon Rinshō Men'eki Gakkai Kaishi, Japanese Journal of Clinical Immunology
https://www.readbyqxmd.com/read/23812439/minimum-thickness-of-all-poly-tibial-component-unicompartmental-knee-arthroplasty-in-patients-younger-than-60-years-does-not-increase-revision-rate-for-aseptic-loosening
#11
Danilo Bruni, Ibrahim Akkawi, Francesco Iacono, Giovanni Francesco Raspugli, Michele Gagliardi, Marco Nitri, Alberto Grassi, Stefano Zaffagnini, Simone Bignozzi, Maurilio Marcacci
PURPOSE: Management of unicompartmental knee osteoarthritis in middle-aged patients is a challenging problem. Despite its functional advantages, UKA still raises questions concerning implant survivorship and an increased revision risk for aseptic loosening mainly due to polyethylene wear. The main purpose of the present study was to investigate whether using the minimum thickness of an all-poly tibial UKA in patients under 60 years of age increases the revision rate for aseptic loosening...
November 2013: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
https://www.readbyqxmd.com/read/23520296/chevron-osteotomy-of-the-first-metatarsal-stabilized-with-an-absorbable-pin-our-5-year-experience
#12
Alberto Morandi, Emanuele Ungaro, Andrea Fraccia, Valerio Sansone
BACKGROUND: The potential requirement for hardware removal originally fueled the development of bioabsorbable pins as an alternative to metal screws for fixing osteotomy sites in foot surgery. More recently, the concern regarding the adverse effects of metal implants may provide further grounds for using bioabsorbable rather than metal fixation. METHODS: This is a prospective study of 383 consecutive patients (439 feet) who underwent a chevron osteotomy to correct a hallux valgus deformity performed between 2005 and 2010...
March 2013: Foot & Ankle International
https://www.readbyqxmd.com/read/23399887/complications-after-tendon-transfers-in-the-foot-and-ankle-using-bioabsorbable-screws
#13
Thomas O Clanton, Alex A Betech, Aaron M Bott, Lauren M Matheny, Braden Hartline, Travis W Hanson, William C McGarvey
BACKGROUND: Tendon transfers are commonly used for correction of pathology or deformity of the foot and ankle. Bioabsorbable implants have been developed as an alternative to metal interference screws. The purpose of this study was to document complications following tendon transfers of the foot and ankle using bioabsorbable poly-L-lactide interference screws. METHODS: A retrospective chart review was used to identify patients in whom either of the 2 senior authors had performed a tendon transfer of the foot and ankle using a bioabsorbable interference screw between 1999 and 2005...
April 2013: Foot & Ankle International
https://www.readbyqxmd.com/read/23384867/research-and-application-of-absorbable-screw-in-orthopedics-a-clinical-review-comparing-pdlla-screw-with-metal-screw-in-patients-with-simple-medial-malleolus-fracture
#14
COMPARATIVE STUDY
Jin Tang, Jin-feng Hu, Wei-chun Guo, Ling Yu, Sheng-hao Zhao
OBJECTIVE: To observe the therapeutic effect of absorbable screw in medial malleolus fracture and discuss its clinical application in orthopedics. METHODS: A total of 129 patients with simple medial malleolus fracture were studied. Among them, 64 patients were treated with poly-D, L-lactic acid (PDLLA) absorbable screws, while the others were treated with metal screws. All the patients were followed up for 12-20 months (averaged 18.4 months) and the therapeutic effect was evaluated according to the American Orthopaedic Foot and Ankle Society clinical rating systems...
2013: Chinese Journal of Traumatology, Zhonghua Chuang Shang za Zhi
https://www.readbyqxmd.com/read/23349379/design-comparison-of-the-inbone-i-versus-inbone-ii-total-ankle-system
#15
REVIEW
Ryan T Scott, Bryan L Witt, Christopher F Hyer
UNLABELLED: Degenerative joint disease of the ankle is a debilitating etiology, in which treatment has been disputed in the literature among healthy active patients. Total ankle arthroplasty had recently gained popularity as long-term outcomes are being reported and advancement in the design of the implants themselves evolves. Multiple implants are available on today's market including the INBONE (Wright Medical technologies, Arlington, TN) Total Ankle System. The second generation INBONE total ankle arthroplasty was launched and approved for use in the United States by the FDA in 2005...
April 2013: Foot & Ankle Specialist
https://www.readbyqxmd.com/read/23263679/correcting-pediatric-flatfoot-with-subtalar-arthroereisis-and-gastrocnemius-recession-a-retrospective-study
#16
COMPARATIVE STUDY
Richard M Jay, Nadia Din
BACKGROUND: Flatfoot deformities are common in children and are treated using many conservative and surgical approaches. Subtalar extra-articular arthroereisis, in particular, limits talar motion, spares the subtalar joint, and prevents excessive subtalar joint pronation. Addressing the underlying equinus deformity with gastrocnemius recession is an important factor in optimizing outcomes in patients with flatfoot deformity. METHODS: This study included 20 children, 4 to 17 years old...
April 2013: Foot & Ankle Specialist
https://www.readbyqxmd.com/read/23259567/how-to-identify-subjects-with-poly-vascular-disease
#17
Charalambos Vlachopoulos, Dimitrios Terentes-Printzios, Christodoulos Stefanadis
Multisite artery or polyvascular disease is common. In the REACH registry, 15.9% of patients with either established atherosclerotic arterial disease or at least 3 risk factors for atherothrombosis had symptomatic polyvascular disease. History of risk factors and known co-morbidities, as well as a thorough physical examination, are mandatory in the initial screening and diagnostic work-up. Various non-invasive imaging techniques (duplex ultrasound, computed tomography angiography, magnetic resonance angiography) can be used for the identification of the polyvascular patient...
November 2012: Current Vascular Pharmacology
https://www.readbyqxmd.com/read/22938643/use-of-poly-ether-ether-ketone-cages-in-foot-and-ankle-surgery
#18
REVIEW
Daniel Niño Gomez, Santiago Eslava, Anain Federico, Yearson Diego, Guillermo Arrondo, German Joannas
PEEK cages are an effective alternative when structural bone graft is needed for different fusions around the foot and ankle. Bone fusion rates are high when PEEK cages are filled with autologous bone. No difference in consolidation time in patients was noticed between the cages fixed with staples and those fixed with cannulated screws. Nerve damage, residual pain at the donor site, and cosmetic problems are avoided with the use of PEEK cages. There is no risk of transmission of hepatitis B, hepatitis C, and HIV when using PEEK cages...
September 2012: Foot and Ankle Clinics
https://www.readbyqxmd.com/read/22926148/techniques-for-the-optimization-of-facial-and-nonfacial-volumization-with-injectable-poly-l-lactic-acid
#19
REVIEW
Z Paul Lorenc
UNLABELLED: With the recognition of the key role of volume loss in the facial aging process, injectable dermal fillers and volumizers have become increasingly important treatment options for recontouring and rejuvenating the aging face. While replacement fillers effectively correct individual lines and wrinkles, volumizing agents that replace collagen provide a longer-lasting, volume-based alternative. Poly-L-lactic acid (PLLA) has been shown to increase dermal thickness and volume for up to 2 years and beyond...
October 2012: Aesthetic Plastic Surgery
https://www.readbyqxmd.com/read/22615148/short-and-long-term-peripheral-nerve-regeneration-using-a-poly-lactic-co-glycolic-acid-scaffold-containing-nerve-growth-factor-and-glial-cell-line-derived-neurotrophic-factor-releasing-microspheres
#20
Ralph de Boer, Andreas Borntraeger, Andrew M Knight, Marie-Noëlle Hébert-Blouin, Robert J Spinner, Martijn J A Malessy, Michael J Yaszemski, Anthony J Windebank
Addition of neural growth factors to bioengineered scaffolds may improve peripheral nerve regeneration. The aim of this study is to evaluate the short- and long term effect of microsphere delivered nerve growth factor (NGF) and glial cell derived neurotrophic factor (GDNF) in the 10 mm rat sciatic nerve gap. Eighty-four rats were assigned to seven groups (n = 6) at two endpoints (6 and 16 weeks): saline, saline NGF, saline NGF-microspheres, saline GDNF, saline GDNF-microspheres, saline blank microspheres, and autologous nerve graft...
August 2012: Journal of Biomedical Materials Research. Part A
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