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https://www.readbyqxmd.com/read/28944977/characterization-of-dicarboxylic-naphthenic-acid-fraction-compounds-utilizing-amide-derivatization-proof-of-concept
#1
Kevin A Kovalchik, Matthew S MacLennan, Kerry M Peru, Chukwuemeka Ajaero, Dena W McMartin, John V Headley, David D Y Chen
RATIONALE: The characterization of naphthenic acid fraction compounds (NAFCs) in oil sands process affected water (OSPW) is of interest for both toxicology studies and regulatory reasons. Previous studies utilizing authentic standards have identified dicarboxylic naphthenic acids using two-dimensional gas chromatography hyphenated to time-of-flight mass spectrometry (GCxGC/TOFMS). The selective derivatization of hydroxyl groups has also recently aided in the characterization of oxy-NAFCs, and indirectly the characterization of dicarboxylic NAFCs...
September 25, 2017: Rapid Communications in Mass Spectrometry: RCM
https://www.readbyqxmd.com/read/28944759/optimization-of-an-ultralow-dose-high-resolution-pediatric-pet-scanner-design-based-on-monolithic-scintillators-with-dual-sided-digital-sipm-readout-a-simulation-study
#2
Ekaterina Mikhaylova, Valerio Tabacchini, Giacomo Borghi, Pieter Mollet, Ester D'Hoe, Dennis R Schaart, Stefaan Vandenberghe
The goal of this simulation study is the performance evaluation and comparison of six potential designs for a time-of-flight PET scanner for pediatric patients of up to about 12 years of age. It is designed to have a high sensitivity and provide high-contrast and high-resolution images. The simulated pediatric PET is a full ring scanner, consisting of 32 × 32 mm<sup>2</sup> monolithic LYSO:Ce crystals coupled to digital silicon photomultiplier (dSiPM) arrays. The six considered designs differ in axial lengths (27...
September 25, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28944677/a-multiplex-and-label-free-relative-quantification-approach-for-studying-protein-abundance-of-drug-metabolizing-enzymes-in-human-liver-microsomes-using-swath-ms
#3
Rohitash Jamwal, Benjamin J Barlock, Sravani Adusumalli, Ken Ogasawara, Brigitte L Simons, Fatemeh Akhlaghi
We describe a sequential windowed acquisition of all theoretical fragment ion mass spectra (SWATH-MS) based method for label-free, simultaneous, relative quantification of drug metabolism enzymes in human liver microsomes (HLM; n=78). In-solution tryptic digestion was aided by a pressure cycling method which allowed a 90-min incubation time, a significant reduction over classical protocols (12-18 h). Digested peptides were separated on an Acquity UHPLC Peptide BEH C18 column using a 60-min gradient method at a flow rate of 0...
September 25, 2017: Journal of Proteome Research
https://www.readbyqxmd.com/read/28944084/hope-coping-and-psychosocial-adjustment-after-spinal-cord-injury
#4
Pat Dorsett, Timothy Geraghty, Anne Sinnott, Rick Acland
INTRODUCTION: The study was a prospective, longitudinal design. The purpose was to explore the role of hope in the coping and psychosocial adjustment process following a spinal cord injury. The study was conducted at Spinal cord injury rehabilitation units in Queensland, Australia and Christchurch, New Zealand. MATERIALS AND METHODS: This was a longitudinal study conducted in two SCI rehabilitation centres, one in Australia and one in New Zealand. A total of 47 participants with newly acquired traumatic SCI were administered a survey consisting of the Adult Hope Scale; the Moorong Self-Efficacy Scale; the Centre for Epidemiology Studies-Depression Scale (CES-D); Life Satisfaction, Self-Rated Adjustment and Life Problems Subscales of the Life Situation Questionnaire and selected subscales from the Spinal Cord Lesion-related Coping Strategies Questionnaire (SCL-CSQ) and the COPE scales at 6 weeks post injury and 3 months post discharge...
2017: Spinal Cord Series and Cases
https://www.readbyqxmd.com/read/28943632/differences-in-abca1-r219k-polymorphisms-and-serum-indexes-in-alzheimer-and-parkinson-diseases-in-northern-china
#5
Lagai Ya, Zuneng Lu
BACKGROUND ABCA1 R219K single-nucleotide polymorphisms (SNPs) was related to Alzheimer disease (AD) but not Parkinson disease (PD). Here, we analyzed the associations among ABCA1 R219K distribution, serum biomarkers, AD, and PD in a population in northern China. MATERIAL AND METHODS We used the Mini-Mental State Examination (MMSE) and the Hoehn and Yahr scale (H-Y) to evaluate AD and PD progression, separately. ABCA1 R219K was analyzed by matrix-assisted laser desorption ionization time of flight time mass spectrometry (MALDI-TOF-MS)...
September 25, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/28943053/our-experience-with-500-patients-with-benign-paroxysmal-positional-vertigo-reexploring-aetiology-and-reevaluating-mri-investigation
#6
Fei Tan, Constantin Bartels, Rory McConn Walsh
OBJECTIVE: To explore the aetiology of and to evaluate the importance of MRI investigation on the posterior semicircular canal benign paroxysmal positional vertigo in an Irish population. METHODS: A retrospective observational study of 500 patients with posterior semicircular canal benign paroxysmal positional vertigo, diagnosed and treated by the senior author over a 10-year period. Most patients underwent an MRI brain and inner ear, following the same scan protocol...
September 21, 2017: Auris, Nasus, Larynx
https://www.readbyqxmd.com/read/28942821/medicinal-plant-products-targeting-quorum-sensing-for-combating-bacterial-infections
#7
REVIEW
Abdelhakim Bouyahya, Nadia Dakka, Abdeslam Et-Touys, Jamal Abrini, Youssef Bakri
Traditional treatment of infectious diseases is based on compounds that aim to kill or inhibit bacterial growth. The bacterial resistance against antibiotics is a serious issue for public health. Today, new therapeutic targets other than the bacterial wall were deciphered. Quorum sensing or bacterial pheromones are molecules called auto-inducer secreted by bacteria to regulate some functions such as antibiotic resistance and biofilms formation. This therapeutic target is well-studied worldwide, nevertheless the scientific data are not updated and only recent researches started to look into its potential as a target to fight against infectious diseases...
August 2017: Asian Pacific Journal of Tropical Medicine
https://www.readbyqxmd.com/read/28942662/-ophthalmological-symptoms-of-measles-and-their-treatment
#8
Mihály Végh, András Hári-Kovács, Hans-Walter Roth, Andrea Facskó
Measles, caused by the Morbilli virus, is a highly (about 95 %) contagious disease affecting primarily children, but without proper immunisation, adults can also be infected. The leading symptoms of the disease are high fever that presents after an incubation period of 9-10 days and the red rash that begins several days after the fever starts. Beyond specific generalized symptoms, measles may have ocular symptoms. The most commonly occurring conjunctivitis, the so-called "red eye symptom", is not characteristic only for measles infection, however, by taking the generalized symptoms it can suggest the diagnosis at the beginning of the disease...
October 2017: Orvosi Hetilap
https://www.readbyqxmd.com/read/28942634/photochemical-transformation-of-nicotine-in-wastewater-effluent
#9
Lushi Lian, Shuwen Yan, Bo Yao, Shen-An Chan, Weihua Song
Nicotine is a highly toxic tobacco alkaloid that is ubiquitous in wastewater effluent. For the first time, we report the identification of the products and the pathways for the photodegradation of nicotine in an effluent matrix under simulated solar irradiation. Nicotine was found to be degraded by triplet state organic matter (3OM*), thus indicating that electron transfer is a preferred reaction mechanism. Using the multivariate statistical strategies orthogonal projection to latent structures discriminant analysis (OPLS-DA) and hierarchical clustering, 49 potential transformation products (TPs) of nicotine were successfully extracted from the water matrix via high-resolution ultra-high-performance liquid chromatography quadrupole time-of-flight mass spectrometry (UHPLC-QTOF-MS)...
September 25, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28941951/on-decentralized-adaptive-full-order-sliding-mode-control-of-multiple-uavs
#10
Xianbo Xiang, Chao Liu, Housheng Su, Qin Zhang
In this study, a novel decentralized adaptive full-order sliding mode control framework is proposed for the robust synchronized formation motion of multiple unmanned aerial vehicles (UAVs) subject to system uncertainty. First, a full-order sliding mode surface in a decentralized manner is designed to incorporate both the individual position tracking error and the synchronized formation error while the UAV group is engaged in building a certain desired geometric pattern in three dimensional space. Second, a decentralized virtual plant controller is constructed which allows the embedded low-pass filter to attain the chattering free property of the sliding mode controller...
September 20, 2017: ISA Transactions
https://www.readbyqxmd.com/read/28941795/avoiding-escalation-from-play-to-aggression-in-adult-male-rats-the-role-of-ultrasonic-calls
#11
Candace J Burke, Theresa M Kisko, Sergio M Pellis, David R Euston
Play fighting is most commonly associated with juvenile animals, but in some species, including rats, it can continue into adulthood. Post-pubertal engagement in play fighting is often rougher and has an increased chance of escalation to aggression, making the use of play signals to regulate the encounter more critical. During play, both juvenile and adult rats emit many 50-kHz calls and some of these may function as play facilitating signals. In the present study, unfamiliar adult male rats were introduced in a neutral enclosure and their social interactions were recorded...
September 20, 2017: Behavioural Processes
https://www.readbyqxmd.com/read/28941677/phenolic-profiling-and-antioxidant-capacity-of-calligonum-azel-maire-a-tunisian-desert-plant
#12
Marwa Bannour, Boutheina Fellah, Gabriele Rocchetti, Samira Ashi-Smiti, Dirk W Lachenmeier, Luigi Lucini, Ayda Khadhri
The comprehensive phenolic fingerprint of Calligonum azel Maire plant fractions, collected from the Tunisian Desert, have been assessed for the first time as a source of natural antioxidants. Total phenolic content (TPC), Trolox Equivalent Antioxidant Capacity (TEAC) in scavenging DPPH, ABTS(+) and Ferric Reducing Antioxidant Power (FRAP) were determined. C. azel Maire showed a relevant content in phenolic compounds, which are related to the antioxidant activity. The flowers presented the highest antioxidant capacity against DPPH free radicals, while the leaves showed the highest scavenging capacity against ABTS...
November 2017: Food Research International
https://www.readbyqxmd.com/read/28941620/safety-and-immunogenicity-of-heterologous-prime-boost-immunization-with-viral-vectored-malaria-vaccines-adjuvanted-with-matrix-m%C3%A2
#13
Navin Venkatraman, Nicholas Anagnostou, Carly Bliss, Georgina Bowyer, Danny Wright, Karin Lövgren-Bengtsson, Rachel Roberts, Ian Poulton, Alison Lawrie, Katie Ewer, Adrian V S Hill
The use of viral vectors in heterologous prime-boost regimens to induce potent T cell responses in addition to humoral immunity is a promising vaccination strategy in the fight against malaria. We conducted an open-label, first-in-human, controlled Phase I study evaluating the safety and immunogenicity of Matrix-M adjuvanted vaccination with a chimpanzee adenovirus serotype 63 (ChAd63) prime followed by a modified vaccinia Ankara (MVA) boost eight weeks later, both encoding the malaria ME-TRAP antigenic sequence (a multiple epitope string fused to thrombospondin-related adhesion protein)...
September 20, 2017: Vaccine
https://www.readbyqxmd.com/read/28941595/lipidome-as-a-predictive-tool-in-progression-to-type-2-diabetes-in-finnish-men
#14
Tommi Suvitaival, Isabel Bondia-Pons, Laxman Yetukuri, Päivi Pöhö, John J Nolan, Tuulia Hyötyläinen, Johanna Kuusisto, Matej Orešič
BACKGROUND: There is a need for early markers to track and predict the development of type 2 diabetes mellitus (T2DM) from the state of normal glucose tolerance through prediabetes. In this study we tested whether the plasma molecular lipidome has biomarker potential to predicting the onset of T2DM. METHODS: We applied global lipidomic profiling on plasma samples from well-phenotyped men (107 cases, 216 controls) participating in the longitudinal METSIM study at baseline and at five-year follow-up...
September 20, 2017: Metabolism: Clinical and Experimental
https://www.readbyqxmd.com/read/28941129/mechanisms-of-drug-resistance-in-cancer-the-role-of-extracellular-vesicles
#15
REVIEW
Priya Samuel, Muller Fabbri, David Raul Francisco Carter
Drug resistance remains a major barrier to the successful treatment of cancer. The mechanisms by which therapeutic resistance arises multifactorial. Recent evidence has shown that extracellular vesicles (EVs) play a role in mediating drug resistance. EVs are small vesicles carrying a variety of macromolecular cargo released by cells into the extracellular space and can be taken up into recipient cells, resulting in transfer of cellular material. EVs can mediate drug resistance by several mechanisms. They can serve as a pathway for sequestration of cytotoxic drugs, reducing the effective concentration at target sites...
September 23, 2017: Proteomics
https://www.readbyqxmd.com/read/28940904/genotyping-of-the-abcg2-gene-using-matrix-associated-laser-desorption-ionisation-time-of-flight-mass-spectrometry
#16
M Tanaka, I Kamada, J Takahashi, T Kimura, Y Tani
OBJECTIVES: The aim of this study was to evaluate the applicability of genotyping of the ABCG2 gene using MALDI-TOF MS and to estimate the allele frequency in the Japanese population. BACKGROUND: Jr (a-) phenotype has a prevalence of approximately 0·05% among Japanese blood donors; DNA-based genotyping was conducted to investigate the molecular basis of the Jr (a-) phenotype along with serological typing. To detect all SNPs of the ABCG2 gene, a high-throughput SNP genotyping platform is needed...
September 21, 2017: Transfusion Medicine
https://www.readbyqxmd.com/read/28940243/novel-contaminants-identified-in-fish-kills-in-the-red-river-watershed-2011-2013
#17
Tammy L Jones-Lepp, Vince Taguchi, Wayne Sovocool, Don Betowski, Patrick Dearmond, Brian Schumacher, Witold Winnik, Rick Mcmillin, Chris Armstrong
Provisional molecular weights and chemical formulas were assigned to four significant previously unidentified contaminants present during active fish kills in the Red River region of Oklahoma. The provisional identifications of these contaminants were determined using high-resolution liquid chromatography-time-of-flight mass spectrometry (LC-TOFMS), LC-Fourier transform ion cyclotron resonance mass spectrometry (LC-FTICRMS), and LC-ion trap mass spectrometry (LC-ITMS). Environmental water samples were extracted using a solid-phase extraction (SPE) method, and sediment samples were extracted using a modified sonication liquid extraction method...
September 21, 2017: Environmental Toxicology and Chemistry
https://www.readbyqxmd.com/read/28939962/hindrances-to-bistable-front-propagation-application-to-wolbachia-invasion
#18
Grégoire Nadin, Martin Strugarek, Nicolas Vauchelet
We study the biological situation when an invading population propagates and replaces an existing population with different characteristics. For instance, this may occur in the presence of a vertically transmitted infection causing a cytoplasmic effect similar to the Allee effect (e.g. Wolbachia in Aedes mosquitoes): the invading dynamics we model is bistable. We aim at quantifying the propagules (what does it take for an invasion to start?) and the invasive power (how far can an invading front go, and what can stop it?)...
September 22, 2017: Journal of Mathematical Biology
https://www.readbyqxmd.com/read/28939340/use-of-ribosomal-proteins-as-biomarkers-for-identification-of-flavobacterium-psychrophilum-by-maldi-tof-mass-spectrometry
#19
Clara Fernández-Álvarez, Yolanda Torres-Corral, Ysabel Santos
Matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF-MS) is a rapid methodology for identification of bacteria that is increasingly used in diagnostic laboratories. This work aimed at evaluating the potential of MALDI-TOF-MS for identification of the main serotypes of Flavobacterium psychrophilum isolated from salmonids, and its discrimination from closely related Flavobacterium spp. A mass spectra library was constructed by analysing 70 F. psychrophilum strains representing the serotypes O1, O2a, O2b and O3, including reference and clinical isolates...
September 19, 2017: Journal of Proteomics
https://www.readbyqxmd.com/read/28939282/determination-of-doping-peptides-via-solid-phase-microelution-and-accurate-mass-quadrupole-time-of-flight-lc-ms
#20
Darío Cuervo, Cynthia Loli, María Fernández-Álvarez, Gloria Muñoz, Daniel Carreras
A complete analytical protocol for the determination of 25 doping-related peptidic drugs and 3 metabolites in urine was developed by means of accurate-mass quadrupole time-of-flight (Q-TOF) LC-MS analysis following solid-phase extraction (SPE) on microplates and conventional SPE pre-treatment for initial testing and confirmation, respectively. These substances included growth hormone releasing factors, gonadotropin releasing factors and anti-diuretic hormones, with molecular weights ranging from 540 to 1320Da...
September 5, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
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