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Poly wear

Eva García-Millán, Mónica Quintáns-Carballo, Francisco Javier Otero-Espinar
Drug nanosuspensions (NSs) show a significant potential to improve loading and release properties of the poorly water soluble drug triamcinolone acetonide (TA) from poly(hydroxyethyl methacrylate) (pHEMA) soft contact lenses. In this work, TA NSs were developed by a controlled precipitation method using a fractional factorial Plackett-Burmann design. Poloxamer 407 (PL) and polyvinyl alcohol (PVA) as stabilizing agents were selected. NSs were characterized in terms of their drug content, particle size and morphology...
April 12, 2017: International Journal of Pharmaceutics
James M Friedman, Mackenzie L Sennett, Marcelo B Bonadio, Kerry O Orji, Alexander L Neuwirth, Niobra Keah, James L Carey, Franklin T Moutos, Bradley T Estes, Farshid Guilak, Henning Madry, Robert L Mauck, George R Dodge
Objective To test different fixation methods of a 3-dimensionally woven poly(ϵ-caprolactone) (PCL) scaffold within chondral defects of a weightbearing large animal model. Methods Full thickness chondral defects were made in the femoral condyles of 15 adult male Yucatan mini-pigs. Two surgical approaches were compared including total arthrotomy (traditional) and a retinaculum-sparing, minimally invasive surgery (MIS) approach. Following microfracture (MFX), scaffolds were placed without fixation or were fixed with fibrin glue, suture, or subchondral anchor...
April 1, 2017: Cartilage
Kenichi Watanabe, Toru Moro, Masayuki Kyomoto, Kenichi Saiga, Shuji Taketomi, Yuho Kadono, Yoshio Takatori, Sakae Tanaka, Kazuhiko Ishihara
One of the important factors in determining the success of joint replacement is the wear performance of polyethylene. Although highly crosslinked polyethylene (CLPE) is presently used, it is still not adequate. We have developed a surface modification technology using poly(2-methacryloyloxyethyl phosphorylcholine) (PMPC) in an attempt to improve wear performance. In this study, we evaluated the wear and creep deformation resistances of 3-mm and 6-mm thick PMPC-grafted CLPE disks, set on a metal back-plate, with and without a sham screw hole...
March 6, 2017: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
Michelina Catauro, Flavia Bollino, Roberto Giovanardi, Paolo Veronesi
Surface modification of metallic implants is a promising strategy to improve tissue tolerance, osseointegration and corrosion resistance of them. In the present work, bioactive and biocompatible organic-inorganic hybrid coatings were prepared using a sol-gel dip coating route. They consist of an inorganic TiO2 matrix in which different percentages of poly(ε-caprolactone) (PCL), a biodegradable and biocompatible polymer, were incorporated. The coatings were used to modify the surface of Ti6Al4V substrates in order to improve their wear and corrosion resistance...
May 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
Samy Yousef, Annamaria Visco, Giovanna Galtieri, Davide Nocita, Claudia Espro
The majority of artificial joints incorporate biomedical grade Ultra High Molecular Weight Poly Ethylene (UHMWPE), whose wear is considered most important in controlling service time of the whole joint. The aim of this work was to improve wear resistance of UHMWPE through the addition of 0.5-2.0wt% of Carbon Nano Filler (CNF) and 2% wt of Paraffin Oil (PO) using ball milling (BM) and extrusion techniques (EX). The wear tests on these nanocomposites were conducted by a pin on disc in dry (air) and wet media (simulated synovial fluid or artificial lubricant, and bovine synovial fluid or natural lubricant)...
April 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
Yi Cao, Dangsheng Xiong, Kun Wang, Yuxiang Niu
Tissue engineering for articular cartilage repair has shown success in ensuring the integration of neocartilage with surrounding tissue, but the rapid restoration of biomechanical and biotribological functions remains a significant challenge. Poly (vinyl alcohol) (PVA) hydrogel is regarded as a potential articular cartilage replacement for its fair mechanical strength and low surface friction, while its lack of bioactivity limits its utility. Combining the advantages of tissue engineering materials and PVA hydrogel, we developed a semi-degradable porous PVA hydrogel through addition of ploy (lactic-co-glycolic acid) (PLGA) microspheres and salt-leaching technique...
February 2, 2017: Journal of the Mechanical Behavior of Biomedical Materials
Lindsay E O'Donnell, Hasanain K A Alalwan, Ryan Kean, Gareth Calvert, Christopher J Nile, David F Lappin, Douglas Robertson, Craig Williams, Gordon Ramage, Leighann Sherry
Approximately 20  % of the UK population wear some form of denture prosthesis, resulting in denture stomatitis in half of these individuals. Candida albicans is primarily attributed as the causative agent, due to its biofilm -forming ability. Recently, there has been increasing evidence of C. albicans biofilm heterogeneity and the negative impact it can have clinically; however, this phenomenon has yet to be studied in relation to denture isolates. The aims of this study were to evaluate C. albicans biofilm formation of clinical denture isolates in a denture environment and to assess antimicrobial activity of common denture cleansers against these tenacious communities...
January 2017: Journal of Medical Microbiology
Hernan Garate, Micaela Bianchi, Lía I Pietrasanta, Silvia Goyanes, Norma B D'Accorso
Hierarchical assembly of hard/soft nanoparticles holds great potential as reinforcements for polymer nanocomposites with tailored properties. Here, we present a facile strategy to integrate polystyrene-grafted carbon nanotubes (PSgCNT) (0.05-0.3 wt %) and poly(styrene-b-[isoprene-ran-epoxyisoprene]-b-styrene) block copolymer (10 wt %) into epoxy coatings using an ultrasound-assisted noncovalent functionalization process. The method leads to cured nanocomposites with core-shell block copolymer (BCP) nanodomains which are associated with carbon nanotubes (CNT) giving rise to CNT-BCP hybrid structures...
December 22, 2016: ACS Applied Materials & Interfaces
Samuel Martin, Bharat Bhushan
Superoleophobic surfaces that exhibit self-cleaning, antifouling, low-drag, and anti-smudge properties with high transparency are of interest in industrial applications including optical devices, solar panels, and self-cleaning windows. In many superoleophobic surfaces created to date, the lack of mechanical durability has been an issue. In this work, for the first time, transparent, wear-resistant, superhydrophobic and superoleophobic surfaces were developed for polydimethylsiloxane (PDMS) using a simple and scalable fabrication technique...
February 15, 2017: Journal of Colloid and Interface Science
Toru Moro, Yoshio Takatori, Sakae Tanaka, Kazuhiko Ishihara, Hiromi Oda, Yoon Taek Kim, Takashige Umeyama, Eisei Fukatani, Hideya Ito, Masayuki Kyomoto, Hirofumi Oshima, Takeyuki Tanaka, Hiroshi Kawaguchi, Kozo Nakamura
To reduce the production of wear particles and subsequent aseptic loosening, we created a human articular cartilage-mimicked surface for a highly cross-linked polyethylene liner, whose surface grafted layer consisted of a biocompatible phospholipid polymer, poly(2-methacryloyloxyethyl phosphorylcholine). Although our previous in vitro findings showed that poly(2-methacryloyloxyethyl phosphorylcholine)-grafted particles were biologically inert and caused no subsequent bone resorptive responses, and poly(2-methacryloyloxyethyl phosphorylcholine) grafting markedly decreased wear in hip joint simulator tests, the clinical safety, and in vivo wear resistance of poly(2-methacryloyloxyethyl phosphorylcholine)-grafted highly cross-linked polyethylene liners remained open to question...
November 3, 2016: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
Carla Thais Rosada Peruchi, Regina Célia Poli-Frederico, Alexandrina Aparecida Maciel Cardelli, Marina de Lourdes Calvo Fracasso, Carina Gisele Costa Bispo, Rejane Dias Neves-Souza, Jefferson Rosa Cardoso, Sandra Mara Maciel
The aim of this study was to investigate the association between oral health status and central obesity (CO) in Brazilian independent-living elderly. A cross-sectional study was carried out in a sample of 489 elderly, who were participants of the Study on Aging and Longevity, in Londrina, state of Parana. The number of natural teeth and use of prostheses were evaluated according to the World Health Organization criteria. The presence of CO was assessed using measures of waist circumference (WC) and waist-hip ratio (WHR)...
October 24, 2016: Brazilian Oral Research
A C Paulus, S Haßelt, V Jansson, A Giurea, H Neuhaus, T M Grupp, S Utzschneider
Introduction. Increasing interest developed in the use of carbon-fiber-reinforced-poly-ether-ether-ketones (CFR-PEEK) as an alternative bearing material in knee arthroplasty. The effects of CFR-PEEK wear in in vitro and animal studies are controversially discussed, as there are no data available concerning human tissue. The aim of this study was to analyze human tissue containing CFR-PEEK as well as UHMWPE wear debris. The authors hypothesized no difference between the used biomaterials. Methods and Materials...
2016: BioMed Research International
Olof Sterner, Rudolf Aeschlimann, Stefan Zürcher, Kathrine Osborn Lorenz, Joseph Kakkassery, Nicholas D Spencer, Samuele G P Tosatti
Purpose: To characterize the effect of lubricant composition and in vitro ageing on the coefficient of friction (CoF) of a wide range of commercially available soft contact lenses (SCLs). Methods: The CoF of SCLs was characterized by means of microtribometry against a mucin-coated glass disk. One reusable (RU) silicone-hydrogel (SiHy) lens, senofilcon A, and two daily disposable (DD) lenses, etafilcon A (hydrogel) and nelfilcon A (hydrogel), were tested under different lubricant solutions, including a tear-like fluid (TLF) containing proteins and lipids...
October 1, 2016: Investigative Ophthalmology & Visual Science
T S Anirudhan, Anoop S Nair, J Parvathy
An extended wear therapeutic contact lens (TCL) for the sustained delivery of timolol maleate (TML) was fabricated based on molecular imprinting technique. The designed TCL comprised of a TML imprinted copolymer of carboxymethyl chitosan-g-hydroxy ethyl methacrylate-g-polyacrylamide (CmCS-g-HEMA-g-pAAm) embedded onto a poly HEMA matrix (pHEMA). Successful reloading of TML onto the lens was monitored using a simple and novel UV-Visible spectrophotometric method which showed an excellent reloading capacity of 6...
December 2016: European Journal of Pharmaceutics and Biopharmaceutics
Allen O Osaheni, Eric B Finkelstein, Patrick T Mather, Michelle M Blum
Hydrogels display a great deal of potential for a wide variety of biomedical applications. Often times the performance of these biomimetic materials is limited due to inferior friction and wear properties. This manuscript presents a method inspired by the tribological phenomena observed in nature for enhancing the lubricious properties of poly (vinyl alcohol) (PVA) hydrogels. This was achieved by blending PVA with various amounts of zwitterionic polymer, poly ([2-(methacryloyloxy) ethyl] dimethyl-(3-sulfopropyl) ammonium hydroxide)) (pMEDSAH)...
September 17, 2016: Acta Biomaterialia
Nijil L Vasukutty, Tahawwar Hasnat Ahmad Minhas
INTRODUCTION: Metal toxicity from metal-on-metal hip replacements is now well documented and several large series have reported local reactions. Although less common, there are reports of similar reactions from failed ceramic liners. Systemic effects documented in literature have been grouped into cardiac, neuro-ocular and thyroid signs. METHODS AND RESULTS: We report a case of a patient who had revision for fractured ceramic liner to metal on polyethylene. Third body effect of the ceramic particles led to wear through of the poly liner and the head directly articulating with metal shell...
July 25, 2016: Hip International: the Journal of Clinical and Experimental Research on Hip Pathology and Therapy
Wei Yin, Lei Shan, Hongyu Lu, Yelong Zheng, Zhiwu Han, Yu Tian
Biological materials immersed in vegetable and mineral oil, such as rattan armor and wooden sleepers, have been extensively used since ancient times because of their excellent mechanical properties. This study quantitatively investigated the viscoelasticity and tribological performance of lignum vitae immersed in poly-alpha-olefin (PAO) and tung oils (Aleuritesfordii Hemsl.) to reveal the mechanism of impact resistance. The acceleration of samples immersed in tung oil was higher than that of dry and PAO-immersed samples in the first impact...
2016: Scientific Reports
Efstathia Andrikopoulou, Panagiotis Zoidis, Ioli-Ioanna Artopoulou, Asterios Doukoudakis
OBJECTIVE: This clinical report presents the use of a modified poly ether-ether ketone material as an alternative material for the fabrication of resin-bonded fixed dental prosthesis (RBFDP) framework. This new material can be used for patients allergic to metals, maintaining the same high esthetic demand of ceramics, presenting light weightness and a flexibility similar to bone as a distinct advantage over ceramic materials. CONCLUSIONS: The use of a BioHPP RBFDP framework could be considered as an alternative restoration for the replacement of missing lateral incisors in young patients with cleft palate defects...
July 2016: Journal of Esthetic and Restorative Dentistry
Roger A E Wright, Kewei Wang, Jun Qu, Bin Zhao
The development of high performance lubricants has been driven by increasingly growing industrial demands and environmental concerns. Herein, we demonstrate oil-soluble polymer brush-grafted inorganic nanoparticles (hairy NPs) as highly effective lubricant additives for friction and wear reduction. A series of oil-miscible poly(lauryl methacrylate) brush-grafted silica and titania NPs were synthesized by surface-initiated atom transfer radical polymerization. These hairy NPs showed exceptional stability in poly(alphaolefin) (PAO) base oil; no change in transparency was observed after being kept at -20, 22, and 100 °C for ≥55 days...
July 18, 2016: Angewandte Chemie
Michael Desanker, Blake Johnson, Afif M Seyam, Yip-Wah Chung, Hassan S Bazzi, Massimiliano Delferro, Tobin J Marks, Q Jane Wang
A major challenge in lubrication technology is to enhance lubricant performance at extreme temperatures that exceed conventional engine oil thermal degradation limits. Soft noble metals such as silver have low reactivity and shear strength, which make them ideal solid lubricants for wear protection and friction reduction between contacting surfaces at high temperatures. However, achieving adequate dispersion in engine lubricants and metallic silver deposition over predetermined temperatures ranges presents a significant chemical challenge...
June 1, 2016: ACS Applied Materials & Interfaces
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