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https://www.readbyqxmd.com/read/28103203/the-change-in-nt-pro-bnp-and-post-ptmc-echocardiography-parameters-in-patients-with-mitral-stenosis-a-pilot-study
#1
Morteza Safi, Fariba Bayat, Zahra Ahmadi, Masood Shekarchizadeh, Isa Khaheshi, Mohammadreza Naderian
BACKGROUND: The change in the level of NT-Pro-BNP (N-terminal Pro-Brain Natriuretic Peptide) is now considered as a reflection of the hemodynamic alterations and its circulatory reductions reported early after successful PTMC (percutaneous transvenous mitral commissurotomy). The present study aims to assess the change in the level of NT-Pro BNP following PTMC in patients with mitral stenosis and also to determine the association between circulatory NT-Pro BNP reduction and post-PTMC echocardiography parameters...
January 18, 2017: Romanian Journal of Internal Medicine, Revue Roumaine de Médecine Interne
https://www.readbyqxmd.com/read/28102875/prevalence-of-abnormal-electrocardiograms-in-swiss-elite-athletes-detected-with-modern-screening-criteria
#2
Tilman Perrin, Lukas Daniel Trachsel, Simon Schneiter, Andrea Menafoglio, Silvia Albrecht, Tony Pirrello, Prisca Eser, Laurent Roten, Boris Gojanovic, Matthias Wilhelm
AIMS OF THE STUDY: Sudden cardiac arrest in athletes is a rare but dramatic event. The value of a routine electrocardiogram (ECG) during preparticipation screening (PPS) remains controversial, partly because of the relatively high number of false positive findings. Our study aimed to evaluate the prevalence of abnormal ECGs in consecutive Swiss elite athletes, overall and with regard to different sports classes, using modern screening criteria. METHODS: We analysed the 12-lead resting ECGs of high-level elite athletes (age ≥14 years) recorded at the Swiss Olympic Medical Centre Magglingen between 2013 and 2016 during routine PPS...
January 19, 2017: Swiss Medical Weekly
https://www.readbyqxmd.com/read/28096758/effects-of-acute-ingestion-of-a-pre-workout-dietary-supplement-with-and-without-p-synephrine-on-resting-energy-expenditure-cognitive-function-and-exercise-performance
#3
Y Peter Jung, Conrad P Earnest, Majid Koozehchian, Elfego Galvan, Ryan Dalton, Dillon Walker, Christopher Rasmussen, Peter S Murano, Mike Greenwood, Richard B Kreider
BACKGROUND: The purpose of this study was to examine the effects of acute ingestion of a pre-workout dietary supplement (PWS) with and without p-synephrine (S) on perceptions of readiness to perform, cognitive function, exercise performance, and markers of safety. METHODS: In a randomized, double-blind, and counterbalanced manner; 25 healthy and recreationally active male and female participants ingested a flavored maltodextrin placebo (PLA), a PWS containing beta-alanine (3 g), creatine nitrate as a salt (2 g), arginine alpha-ketoglutarate (2 g), N-Acetyl-L-Tyrosine (300 mg), caffeine (284 mg), Mucuna pruiriens extract standardized for 15% L-Dopa (15 mg), Vitamin C as Ascorbic Acid (500 mg), niacin (60 mg), folate as folic acid (50 mg), and Vitamin B12 as Methylcobalamin (70 mg) with 2 g of maltodextrin and flavoring; or, the PWS with Citrus aurantium (PWS + S) extract standardized for 30% p-synephrine (20 mg)...
2017: Journal of the International Society of Sports Nutrition
https://www.readbyqxmd.com/read/28088251/lucerastat-an-iminosugar-with-potential-as-substrate-reduction-therapy-for-glycolipid-storage-disorders-safety-tolerability-and-pharmacokinetics-in-healthy-subjects
#4
N Guérard, O Morand, J Dingemanse
BACKGROUND: Lucerastat, an inhibitor of glucosylceramide synthase, has the potential to restore the balance between synthesis and degradation of glycosphingolipids in glycolipid storage disorders such as Gaucher disease and Fabry disease. The safety, tolerability, and pharmacokinetics of oral lucerastat were evaluated in two separate randomized, double-blind, placebo-controlled, single- and multiple-ascending dose studies (SAD and MAD, respectively) in healthy male subjects. METHODS: In the SAD study, 31 subjects received placebo or a single oral dose of 100, 300, 500, or 1000 mg lucerastat...
January 14, 2017: Orphanet Journal of Rare Diseases
https://www.readbyqxmd.com/read/28087552/screening-for-atrial-fibrillation-using-economical-and-accurate-technology-safety-a-pilot-study
#5
Mark Lown, Arthur Yue, George Lewith, Paul Little, Mike Moore
INTRODUCTION: Atrial fibrillation (AF) is a cause of stroke and a marker of atherosclerosis and of all patients with stroke, around 17% have AF. The screening and treatment of AF could prevent about 12% of all strokes. Several relatively low-cost devices with good accuracy now exist which can detect AF including WatchBP and AliveCor. However, they can only measure the ECG or pulse over short time periods. Inexpensive devices such as heart rate monitors, which are widely available, can measure heart rate for prolonged periods and may have potential in screening for AF...
January 13, 2017: BMJ Open
https://www.readbyqxmd.com/read/28079517/pharmacokinetic-and-bioequivalence-study-comparing-a-candesartan-cilexetil-rosuvastatin-calcium-fixed-dose-combination-with-the-concomitant-administration-of-candesartan-cilexetil-and-rosuvastatin-calcium-in-healthy-korean-subjects%C3%A2
#6
Dan-Bee Park, Kyungho Jang, Jae-Won Lee, Cheol-Won Park, Back-Hwan Lee, Min-Gul Kim, Ji-Young Jeon
CONTEXT: A fixed-dose combination (FDC) of candesartan and rosuvastatin was recently developed for the treatment of cardiovascular disease and expected to enhance patient compliance. OBJECTIVE: This study was performed to compare the single-dose pharmacokinetic properties and tolerability of DP-R208 (candesartan and rosuvastatin FDC) to those of each component administered alone in healthy Korean male volunteers. MATERIALS AND METHODS: A total of 40 healthy Korean volunteers were enrolled in this randomized, open-label, single-dose, two-treatment, two-way crossover study...
January 12, 2017: International Journal of Clinical Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/28078546/postoperative-real-time-electrocardiography-monitoring-detects-myocardial-ischemia-a-case-report
#7
Homer Yang, Ashraf Fayad, Alan Chaput, Stuart Oake, Adrian D C Chan, Mary Lou Crossan
PURPOSE: This case report outlines the utility and challenges of remote continuous postoperative electrocardiography ECG) monitoring, which is routed through a secure smartphone to provide real-time detection and management of myocardial ischemia. CLINICAL FEATURES: A 42-yr-old male with previous myocardial infarction and angioplasty underwent a radical prostatectomy. At three hours and 45 min postoperatively, remote real-time ECG monitoring was initiated upon the patient's arrival on a regular surgical ward...
January 11, 2017: Canadian Journal of Anaesthesia, Journal Canadien D'anesthésie
https://www.readbyqxmd.com/read/28065667/a-large-frontal-qrs-t-angle-is-a-strong-predictor-of-the-long-term-risk-of-myocardial-infarction-and-all-cause-mortality-in-the-diabetic-population
#8
Ole May, Christina Boesgaard Graversen, Mia Østergaard Johansen, Hanne Arildsen
BACKGROUND: A large angle between the QRS vector and the T-wave vector (QRS-T angle) in electrocardiograms (ECGs) has recently been introduced as a marker of poor prognosis. The prognostic value in diabetes is unknown. We assessed the long-term predictive power of the frontal plane QRS-T angle in the diabetic population. METHODS: In 1992-93, the diabetic population of the municipality of Horsens, Denmark, was delineated by the prescription method, and an age- and gender-stratified sample of 240 diabetic persons was randomly selected...
December 16, 2016: Journal of Diabetes and its Complications
https://www.readbyqxmd.com/read/28059577/echocardiography-is-useful-to-predict-postoperative-atrial-fibrillation-in-patients-undergoing-isolated-coronary-bypass-surgery-a-prospective-study
#9
Julien Magne, Baptiste Salerno, Dania Mohty, Claire Serena, Florence Rolle, Alessandro Piccardo, Najmeddine Echahidi, Alexandre Le Guyader, Victor Aboyans
OBJECTIVE: Postoperative atrial fibrillation is a major complication following coronary artery bypass graft. We hypothesized that, beyond clinical and electrocardiogram (ECG) data, transthoracic echocardiography could improve the prediction of postoperative atrial fibrillation. METHODS: We prospectively studied 169 patients in sinus rhythm who underwent isolated coronary artery bypass graft in our institution. Clinical, biological, ECG and transthoracic echocardiography data were collected within 24 h before surgery...
January 1, 2017: European Heart Journal. Acute Cardiovascular Care
https://www.readbyqxmd.com/read/28057550/pharmacokinetics-of-lbpt-and-its-primary-metabolites-as-well-as-tolerability-in-the-first-in-human-study
#10
Hongyun Wang, Hongzhong Liu, Ming Liu, Wenjie Wang, Liya Zhu, Haihong Huang, Pei Hu, Ji Jiang
BACKGROUND: LBPT is a novel platelet-activating factor (PAF) receptor antagonist that is developed for the treatment of rheumatoid arthritis. The purpose of this first-in-human study was to evaluate the tolerability and safety of LBPT, to investigate the pharmacokinetics of LBPT and its primary metabolites, as well as to assess the food effect on the pharmacokinetics in healthy Chinese subjects. MATERIALS AND METHODS: LBPT was evaluated in 2 clinical studies. The first study was a double blind, placebo-controlled and ascending dose study...
January 2, 2017: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28057231/anterior-t-wave-inversion-in-young-white%C3%A2-athletes-and-nonathletes-prevalence-and-significance
#11
Aneil Malhotra, Harshil Dhutia, Sabiha Gati, Tee-Joo Yeo, Helder Dores, Rachel Bastiaenen, Rajay Narain, Ahmed Merghani, Gherardo Finocchiaro, Nabeel Sheikh, Alexandros Steriotis, Abbas Zaidi, Lynne Millar, Elijah Behr, Maite Tome, Michael Papadakis, Sanjay Sharma
BACKGROUND: Anterior T-wave inversion (ATWI) on electrocardiography (ECG) in young white adults raises the possibility of cardiomyopathy, specifically arrhythmogenic right ventricular cardiomyopathy (ARVC). Whereas the 2010 European consensus recommendations for ECG interpretation in young athletes state that ATWI beyond lead V1 warrants further investigation, the prevalence and significance of ATWI have never been reported in a large population of asymptomatic whites. OBJECTIVES: This study investigated the prevalence and significance of ATWI in a large cohort of young, white adults including athletes...
January 3, 2017: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/28056601/a-clinical-decision-support-tool-to-assist-with-the-interpretation-of-the-12-lead-electrocardiogram
#12
Cathal Breen, Raymond Bond, Dewar Finlay
This article reports the design and testing of a novel interactive method, abbreviated to ANALYSE (systemAtic aNALYsiS of Electrocardiography) to assist interpretation of 12-lead electrocardiogram. 15 participants interpreted a total of 150 12-lead electrocardiogram recordings randomly using a standard and this novel (ANALYSE) reporting format. The overall aggregated mean score attained using the standard format was 53% (range = 38-82%, standard deviation = 12). Conversely, the overall aggregated mean score attained using ANALYSE format was 75% (range = 55%-93%, standard deviation = 9)...
January 1, 2017: Health Informatics Journal
https://www.readbyqxmd.com/read/28045723/rate-dependent-left-bundle-branch-block-in-an-ambulatory-surgery-patient-a-case-report
#13
Ashraf Farag, Justin Tsai, Sam Deeb, Deidre Putman-Garcia, John D Wasnick, Lydia A Conlay
A 52-year-old woman, ASA II (American Society of Anesthesia classification II) scheduled for cholecystectomy in an ambulatory center, exhibited a wide-complex tachycardia with ectopy on the monitor after induction with propofol and succinylcholine. Blood pressure remained stable; amiodarone was administered for presumed ventricular tachycardia. A 12-lead electrocardiogram (ECG) showed a new left bundle branch block (LBBB) at 98 beats per minute (bpm), which resolved when the heart rate slowed. Surgery was postponed, and both the LBBB and ectopy recurred frequently during the next 24 hours in the intensive care unit, particularly at heart rates >90 bpm...
December 30, 2016: A & A Case Reports
https://www.readbyqxmd.com/read/28045691/ecg-of-the-month-wide-qrs-tachycardias
#14
D Luke Glancy, Theresa A Mills
A 61-year-old man came from out of state to attend a football game. He felt well during the game, but when he stood up to leave, he became dizzy and dyspneic. The symptoms lasted 15 to 20 minutes, and when the paramedics arrived, they diagnosed an idioventricular rhythm and brought the patient to the emergency department where a 12-lead electrocardiogram (ECG) was recorded (Figure 1).
November 2016: Journal of the Louisiana State Medical Society: Official Organ of the Louisiana State Medical Society
https://www.readbyqxmd.com/read/28043059/determining-factors-of-electrocardiographic-abnormalities-in-patients-with-epilepsy-a-case-control-study
#15
Jorge Murilo Barbosa de Sousa, Guilherme Loureiro Fialho, Peter Wolf, Roger Walz, Katia Lin
Sudden unexpected death in epilepsy (SUDEP) is a major cause of mortality in young patients with epilepsy (PWE). Although its mechanisms are still poorly understood, they may include cardiorespiratory dysfunction. Standard 12-lead electrocardiograms (ECGs) were obtained from 62 consecutive patients (aged 18-66y) with a definite diagnosis of epilepsy, without seizures at the day of ECG, and 57 healthy controls matched for sex, age and body mass index (BMI). All ECGs were evaluated by a blinded board-certified cardiologist...
December 20, 2016: Epilepsy Research
https://www.readbyqxmd.com/read/28041756/trauma-induced-acute-myocardial-infarction-due-to-delayed-dissection-of-the-left-anterior-descending-coronary-artery
#16
Magdalena Wilczynska-Golonka, Pawel Rostoff, Aleksander Siniarski, Agnieszka Skrzypek, Andrzej Gackowski, Ewa Konduracka, Jadwiga Nessler
Acute myocardial infarction is a very rare, life-threatening complication of blunt chest trauma. A 27-year-old man with no previous medical history was admitted to the emergency department due to multiple trauma following a car accident. After 48h following the accident, the patient's condition rapidly deteriorated, with severe dyspnea at rest, tachycardia, and increasing chest pain. A 12-lead ECG showed a sinus tachycardia at 120bpm with significant ST-segment elevation in leads V1 to V5, pathologic Q wave in I, aVL, and QS complex in leads V1 to V4...
December 27, 2016: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/28039282/relationships-of-measured-and-genetically-determined-height-with-the-cardiac-conduction-system-in-healthy-adults
#17
Thomas Kofler, Sébastien Thériault, Matthias Bossard, Stefanie Aeschbacher, Selina Bernet, Philipp Krisai, Steffen Blum, Martin Risch, Lorenz Risch, Christine M Albert, Guillaume Paré, David Conen
BACKGROUND: Increasing height is an independent risk factor for atrial fibrillation, but the underlying mechanisms are unknown. We hypothesized that height-related differences in electric conduction could be potential mediators of this relationship. METHODS AND RESULTS: We enrolled 2149 adults aged 25 to 41 years from the general population. Height was directly measured, and a resting 12-lead ECG obtained under standardized conditions. Multivariable linear regression models were used to evaluate the association between measured height and ECG parameters...
January 2017: Circulation. Arrhythmia and Electrophysiology
https://www.readbyqxmd.com/read/28039126/are-olympic-athletes-free-from-cardiovascular-diseases-systematic-investigation-in-2352-participants-from-athens-2004-to-sochi-2014
#18
Antonio Pelliccia, Paolo Emilio Adami, Filippo Quattrini, Maria Rosaria Squeo, Stefano Caselli, Luisa Verdile, Viviana Maestrini, Fernando Di Paolo, Cataldo Pisicchio, Roberto Ciardo, Antonio Spataro
CONTEXT: Olympic athletes represent model of success in our society, by enduring strenuous conditioning programmes and achieving astonishing performances. They also raise scientific and clinical interest, with regard to medical care and prevalence of cardiovascular (CV) abnormalities. OBJECTIVE: Our aim was to assess the prevalence and type of CV abnormalities in this selected athlete's cohort. DESIGN, SETTING AND PARTICIPANTS: 2352 Olympic athletes, mean age 25±6, 64% men, competing in 31 summer or 15 winter sports, were examined with history, physical examination, 12-lead and exercise ECG and echocardiography...
December 30, 2016: British Journal of Sports Medicine
https://www.readbyqxmd.com/read/28034575/complete-right-bundle-branch-block-and-qrs-t-discordance-can-be-the-initial-clue-to-detect-s-icd-ineligibility
#19
Motomi Tachibana, Nobuhiro Nishii, Yoshimasa Morimoto, Satoshi Kawada, Akihito Miyoshi, Hiroyasu Sugiyama, Koji Nakagawa, Atsuyuki Watanabe, Kazufumi Nakamura, Hiroshi Morita, Hiroshi Ito
BACKGROUND: In order to minimize inappropriate shocks of subcutaneous implantable cardioverter-defibrillators (S-ICD), it is important to recognize who is suitable for S-ICD indication. This study aimed to clarify what types of cardiac disease are likely to fulfill the S-ICD screening criteria and ineligible factors for S-ICD in the standard 12-lead electrocardiogram (ECG). METHODS: A total of 348 patients with heart disease were enrolled. They were assessed by supine and standing ECG recording to simulate the 3 S-ICD sensing vectors and standard 12-lead ECG, simultaneously...
December 26, 2016: Journal of Cardiology
https://www.readbyqxmd.com/read/28034442/electrocardiographic-changes-induced-by-endurance-training-and-pubertal-development-in-male-children
#20
Flavio D'Ascenzi, Marco Solari, Francesca Anselmi, Francesca Valentini, Riccardo Barbati, Paola Palmitesta, Marta Focardi, Marco Bonifazi, Sergio Mondillo
Training-induced electrocardiographic changes are common in adult athletes. However, a few data are available on electrocardiogram (ECG) in preadolescent athletes and little is known about the potential changes induced by training on 12-lead electrocardiogram (ECG) at rest. Twelve-lead ECGs at rest and complete echocardiographic examinations were performed in 94 children (57 endurance athletes, 37 sedentary controls; mean age 10.8 ± 0.2 and 10.2 ± 0.2 years, respectively) at baseline and after 5 months of growth and training in athletes and of natural growth in controls...
December 3, 2016: American Journal of Cardiology
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