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https://www.readbyqxmd.com/read/29034749/screening-of-older-patients-for-atrial-fibrillation-in-general-practice-current-evidence-and-its-implications-for-future-practice
#1
Matthew R Fay, David A Fitzmaurice, Ben Freedman
BACKGROUND: Individuals with atrial fibrillation (AF) face a fivefold increased risk of ischaemic stroke compared with those without the condition. Recent studies suggest that individuals with asymptomatic AF also face an increased risk of ischaemic stroke, but their condition is often not recognized and diagnosed until an ischaemic stroke event has occurred. Identification of individuals with undiagnosed AF at increased risk for stroke is critical in promoting optimal intervention with anticoagulants...
December 2017: European Journal of General Practice
https://www.readbyqxmd.com/read/29033578/right-ventricular-systolic-function-in-hypertensive-heart-failure
#2
O A Oketona, M O Balogun, A O Akintomide, O E Ajayi, R A Adebayo, T O Mene-Afejuku, O T Oketona, O J Bamikole
BACKGROUND: Heart failure (HF) is a major cause of cardiovascular admissions and hypertensive heart failure (HHF) is the most common cause of HF admissions in sub-Saharan Africa, Nigeria inclusive. Right ventricular (RV) dysfunction is being increasingly recognized in HF and found to be an independent predictor of adverse outcomes in HF. This study aimed to determine the prevalence of RV systolic dysfunction in HHF by several echocardiographic parameters. METHODOLOGY: One hundred subjects with HHF were recruited consecutively into the study along with 50 age and sex-matched controls...
2017: Vascular Health and Risk Management
https://www.readbyqxmd.com/read/29030380/association-between-qt-interval-components-and-sudden-cardiac-death-the-aric-study-atherosclerosis-risk-in-communities
#3
Wesley T O'Neal, Matthew J Singleton, Jason D Roberts, Larisa G Tereshchenko, Nona Sotoodehnia, Lin Y Chen, Gregory M Marcus, Elsayed Z Soliman
BACKGROUND: Several reports have demonstrated that prolongation of the QT interval is associated with sudden cardiac death (SCD). However, it is unknown whether any of the components within the QT interval are responsible for its association with SCD. METHODS AND RESULTS: We examined the association of the individual QT-interval components (R-wave onset to R-peak, R-peak to R-wave end, ST-segment, T-wave onset to T-peak, and T-peak to T-wave end) with SCD in 12 241 participants (54±5...
October 2017: Circulation. Arrhythmia and Electrophysiology
https://www.readbyqxmd.com/read/29029774/immediate-coronary-angiography-in-survivors-of-out-of-hospital-cardiac-arrest-without-obvious-extracardiac-cause-who-benefits
#4
Z Moutacalli, J-L Georges, B Ajlani, G Cherif, E El Beainy, G Gibault-Genty, E Blicq, C Charbonnel, R Convers-Domart, F Boutot, J-M Caussanel, B Lemaire, S Legriel, B Livarek
BACKGROUND: Immediate coronary angiography (iCA) and primary percutaneous coronary angioplasty (pPCI) in patients successfully resuscitated after out-of-hospital cardiac arrest (OHCA) of suspected cardiac cause is controversial. Our aims were to assess the results of iCA, the prognostic impact of pPCI after OHCA, and to identify subgroups most likely to benefit from this strategy. METHODS: In this single-centre retrospective study, patients aged ≥18 years with sustained return of spontaneous circulation after OHCA and no evidence of a non-cardiac cause underwent routine iCA at admission, with pPCI if indicated...
October 10, 2017: Annales de Cardiologie et D'angéiologie
https://www.readbyqxmd.com/read/29028356/aggregation-of-a-cationic-gemini-surfactant-with-a-chelating-molecule-and-effects-from-calcium-ion
#5
Weiwei Zhao, Kai Song, Yao Chen, Hua Wang, Zhang Liu, Qiang Shi, Jianbin Huang, Yilin Wang
The aggregation behavior of a cationic ammonium gemini surfactant hexamethylene-1,6-bis(dodecyldimethylammonium bromide) (12-6-12) with a chelating molecule ethylenediaminetetraacetic acid (EDTA) and the effects of calcium bromide (CaBr2) on the structure and morphology of the aggregates in the mixture have been investigated by surface tension, isothermal titration microcalorimetry, electrical conductivity, ζ potential, dynamic light scattering, cryogenic transmission electron microscopy, freeze-fracture transmission electron microscopy and 1H NMR techniques...
October 13, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/29024212/prevalence-and-predictive-factors-of-left-atrial-tachycardia-occurring-after-second-generation-cryoballoon-ablation-of-atrial-fibrillation
#6
Alexis Hermida, Maciej Kubala, Sarah Traullé, Otilia Buiciuc, Serge Quenum, Jean-Sylvain Hermida
INTRODUCTION: Assess the prevalence and predictors of Left Atrial Tachycardia (LAT) after cryoballoon ablation of pulmonary veins. METHODS AND RESULTS: Patients who underwent catheter ablation of pulmonary veins with a second-generation cryoballoon for symptomatic paroxysmal (151/270, 56%) or persistent (119/270, 44%) atrial fibrillation were entered in a single-centre prospective registry. Patients who experienced post-cryoballoon LAT (pcryo-LAT) were selected on the basis of 12-lead ECG characteristics...
October 11, 2017: Journal of Cardiovascular Electrophysiology
https://www.readbyqxmd.com/read/29019518/prevalence-and-predictive-value-of-electrocardiographic-abnormalities-in-pulmonary-hypertension-evidence-from-the-pan-african-pulmonary-hypertension-cohort-papuco-study
#7
Irina Balieva, Anastase Dzudie, Friedrich Thienemann, Ana O Mocumbi, Kamilu Karaye, Mahmoud U Sani, Okechukwu S Ogah, Adriaan A Voors, Andre Pascal Kengne, Karen Sliwa
BACKGROUND: Pulmonary hypertension (PH) is prevalent in Africa and is still often diagnosed only at an advanced stage, therefore it is associated with poor quality of life and survival rates. In resource-limited settings, we assessed the diagnostic utility of standard 12-lead electrocardiograms (ECG) to detect abnormalities indicating PH. METHODS: Sixty-five patients diagnosed with PH were compared with 285 heart disease-free subjects. The prevalence and diagnostic performance of ECG features indicative of PH and right heart strain were calculated...
October 11, 2017: Cardiovascular Journal of Africa
https://www.readbyqxmd.com/read/29016797/multiple-clinical-profiles-of-families-with-the-short-qt-syndrome
#8
D Akdis, A M Saguner, A Medeiros-Domingo, A Schaller, C Balmer, J Steffel, C Brunckhorst, F Duru
Aims: Short QT syndrome (SQTS) is a rare cardiac channelopathy characterized by a shortened corrected QT (QTc)-interval that can lead to ventricular arrhythmias and sudden cardiac death. The aim of this study was to investigate the clinical phenotypes and long-term outcomes of three families harbouring genetic mutations associated with the SQTS. Methods and results: Clinical data included medical history, physical examination, 12-lead ECG, 24-h Holter-ECG, and transthoracic echocardiography from three index patients and their first-degree relatives...
July 19, 2017: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/29016756/the-electrocardiogram-as-a-predictor-of-successful-pharmacological-cardioversion-and-progression-of-atrial-fibrillation
#9
Stef Zeemering, Theo A R Lankveld, Pietro Bonizzi, Ione Limantoro, Sebastiaan C A M Bekkers, Harry J G M Crijns, Ulrich Schotten
Aims: Non-invasive characterization of atrial fibrillation (AF) substrate complexity based on the electrocardiogram (ECG) may improve outcome prediction in patients receiving rhythm control therapies for AF. Multiple parameters to assess AF complexity and predict treatment outcome have been suggested. A comparative study of the predictive performance of complexity parameters on response to therapy and progression of AF in a large patient population is needed to standardize non-invasive analysis of AF...
July 26, 2017: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/28992960/tp-e-interval-and-tp-e-qt-ratio-in-patients-with-celiac-disease
#10
K Demirtaş, Ç Yayla, M Yüksel, B Açar, S Ünal, A G Ertem, M Kaplan, M Y Akpinar, Z M Y Kiliç, E Kayaçetin
OBJECTIVES: Celiac disease is a chronic immune-mediated disease of the small intestine. It has been known that dilated cardiomyopathy and ischemic coronary artery disease have become more frequent in patients with celiac disease. The aim of the study was to assess Tp-e interval and Tp-e/QT ratio in patients with celiac disease. MATERIAL AND METHODS: This study was conducted at a single center in collaboration with gastroenterology and cardiology clinics. Between January 2014 and June 2015, a total of 76 consecutive patients were enrolled (38 patients with celiac disease and 38 control subjects)...
October 7, 2017: Revista Clínica Española
https://www.readbyqxmd.com/read/28985886/debatable-issues-in-automated-ecg-reporting
#11
Peter W Macfarlane, Jay W Mason, Paul Kligfield, Claire E Sommargren, Barbara Drew, Peter van Dam, Roger Abächerli, David E Albert, Morrison Hodges
Although automated ECG analysis has been available for many years, there are some aspects which require to be re-assessed with respect to their value while newer techniques which are worthy of review are beginning to find their way into routine use. At the annual International Society of Computerized Electrocardiology conference held in April 2017, four areas in particular were debated. These were a) automated 12 lead resting ECG analysis; b) real time out of hospital ECG monitoring; c) ECG imaging; and d) single channel ECG rhythm interpretation...
September 1, 2017: Journal of Electrocardiology
https://www.readbyqxmd.com/read/28979516/myocardial-infarction-in-intensive-care-units-a-systematic-review-of-diagnosis-and-treatment
#12
REVIEW
Iain Carroll, Thomas Mount, Dougal Atkinson
INTRODUCTION: Patients in the intensive care unit are vulnerable to myocardial injury from a variety of causes, both ischaemic and non-ischaemic. It is challenging for ICU clinicians to apply the conventional guidance concerning diagnosis and treatment. We conducted this review to examine the evidence concerning diagnosis and treatment of myocardial infarction in the ICU. METHODS: A systematic review was performed to identify relevant studies. RESULTS: 19 studies concerning use of ECG, cardiac enzymes, echocardiography and angiography were identified...
November 2016: J Intensive Care Soc
https://www.readbyqxmd.com/read/28974832/qtc-interval-prolongation-and-hemorrhagic-stroke-any-difference-between-acute-spontaneous-intracerebral-hemorrhage-and-acute-non-traumatic-subarachnoid-hemorrhage
#13
Osama Shukir Muhammed Amin, Sarwer Jamal Al-Bajalan, Alaa Mubarak
BACKGROUND: A variety of ECG changes occur as an aftermath of stroke. Prolongation of the QTc interval is a well-documented change. We analyzed QTc interval prolongation among patients with acute hemorrhagic strokes. METHODS: This observational study was conducted at the Emergency Department of Sulaymaniyah General Teaching Hospital and Shar Hospital from September 1(st), 2014 to August 31(st), 2015. Fifty patients who developed acute spontaneous hypertensive intracerebral hemorrhage (ICH) and 50 patients who developed acute non-traumatic subarachnoid hemorrhage (SAH) were included in the study...
June 2017: Medical Archives
https://www.readbyqxmd.com/read/28973357/a-prospective-analysis-of-neuromonitoring-for-confirmation-of-lead-placement-in-dorsal-root-ganglion-stimulation
#14
Steven M Falowski, Andreas Dianna
BACKGROUND: Dorsal root ganglion stimulation is a neuromodulation therapy used for chronic neuropathic pain. Typically, patients are awakened intraoperatively to confirm adequate placement. OBJECTIVE: To determine whether neuromonitoring can confirm placement in an asleep patient. METHODS: This is a prospective analysis of 12 leads placed in 6 patients. Lead confirmation was confirmed by awake intraoperative testing, as well as asleep testing utilizing neuromonitoring...
August 2, 2017: Operative Neurosurgery (Hagerstown, Md.)
https://www.readbyqxmd.com/read/28971615/efficacy-safety-and-tolerability-of-once-daily-abediterol-in-patients-with-stable-persistent-asthma-a-phase-ii-randomized-7-day-crossover-study
#15
Jutta Beier, Rainard Fuhr, Beatriz Seoane, Eric Massana, Gonzalo de Miquel, Helena Pujol, Sandrine Ruiz
Abediterol is a once-daily, long-acting β2 -adrenergic agonist in development for the treatment of asthma and chronic obstructive pulmonary disease. We assessed the efficacy, safety, and tolerability of three dose levels of abediterol, given once daily for 7 days in patients with stable, persistent asthma. This was an ascending-dose, three-period incomplete crossover study design investigating three dose levels of abediterol versus placebo (EudraCT No. 2008-003732-38). Twenty-eight male patients (25-59 years) were randomized to one of four treatment sequences (1:1:1:1)...
October 2017: Pharmacology Research & Perspectives
https://www.readbyqxmd.com/read/28967984/thorough-qt-qtc-evaluation-of-the-cardiac-safety-of-secnidazole-at-therapeutic-and-supratherapeutic-doses-in-healthy-individuals
#16
Borje Darpo, Hongqi Xue, Nikki Adetoro, Barbara G Matthews, Helen S Pentikis
SYM-1219, a novel oral granule formulation of secnidazole, is under development as single-dose treatment for bacterial vaginosis. This 4-way, randomized, crossover study evaluated the effects of SYM-1219 on electrocardiographic (ECG) parameters in 52 healthy subjects. Subjects were administered single doses of SYM-1219, 2 g (proposed therapeutic dose), 6 g (supratherapeutic dose), placebo, and moxifloxacin (positive control). Serial digital 12-lead ECGs were recorded pre- and postdose; blood samples were taken to determine plasma secnidazole concentrations...
October 2, 2017: Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/28966313/analysis-of-morphological-characteristics-and-origins-of-idiopathic-premature-ventricular-contractions-under-a-12-lead-electrocardiogram-in-children-with-structurally-normal-hearts
#17
Jianbin Jiang, Yuee He, Huixian Qiu, Yuanhai Zhang, Maoping Chu, Yuechun Li, Qi Chen
Up to 40% of healthy children have premature ventricular complexes or contractions (PVCs) detected with 24-hour Holter monitoring. We aimed to investigate the morphological characteristics and origins of idiopathic PVCs under a 12-lead electrocardiogram in children with structurally normal hearts. All asymptomatic monomorphic PVC patients with structurally normal hearts under 18 years of age were included in this retrospective study. Characteristics of PVCs in lead V1 under a 12-lead electrocardiogram were classified as left bundle branch block (PVC-LBBB) or right bundle branch block (PVC-RBBB)...
September 30, 2017: International Heart Journal
https://www.readbyqxmd.com/read/28965260/the-t-peak-to-t-end-interval-a-novel-ecg-marker-for-ventricular-arrhythmia-and-appropriate-icd-therapy-in-patients-with-hypertrophic-cardiomyopathy
#18
Leon Dinshaw, Julia Münch, Jannis Dickow, Susanne Lezius, Stephan Willems, Boris A Hoffmann, Monica Patten
INTRODUCTION: Hypertrophic cardiomyopathy (HCM) is associated with an increased risk of sudden cardiac death (SCD) primarily due to ventricular arrhythmia (VA). In patients (pts.) with a high risk of SCD, the implantation of an intracardiac cardioverter defibrillator (ICD) is thus indicated. Previous studies suggest that a prolonged interval between the peak and the end of the T wave, T-peak to T-end (TpTe), is associated with an elevated risk of VA and SCD in various clinical settings...
September 30, 2017: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
https://www.readbyqxmd.com/read/28965135/chronic-phase-improvements-in-electrocardiographic-and-echocardiographic-manifestations-of-left-ventricular-hypertrophy-after-alcohol-septal-ablation-for-drug-refractory-hypertrophic-obstructive-cardiomyopathy
#19
Junya Matsuda, Mitsunobu Kitamura, Morimasa Takayama, Yoichi Imori, Junsuke Shibuya, Yoshiaki Kubota, Hideto Sangen, Shunichi Nakamura, Hitoshi Takano, Kuniya Asai, Wataru Shimizu
After alcohol septal ablation (ASA), regression of left ventricular hypertrophy (LVH) has been observed in several studies using echocardiography or cardiac magnetic resonance, and favorable changes of myocardial excitation have been expected. However, no studies have focused on the alteration of electrocardiography (ECG) findings after ASA. Therefore, we evaluated serial changes in ECG parameters during the chronic phase after ASA for drug-refractory hypertrophic obstructive cardiomyopathy (HOCM). From 1998 to 2014, we performed 187 ASA procedures in 157 drug-refractory HOCM patients...
September 30, 2017: Heart and Vessels
https://www.readbyqxmd.com/read/28958871/two-year-clinical-outcome-after-a-single-cryoballoon-ablation-procedure-a-comparison-of-first-and-second-generation-cryoballoons
#20
Alexandre Zhao, Fabien Squara, Eloi Marijon, Olivier Thomas
BACKGROUND: The ablation of paroxysmal atrial fibrillation (PAF) by cryoballoon has increased dramatically in recent years. However, there are few data comparing first- and second-generation cryoballoons. AIM: To compare safety and mid-term (2-year) efficacy of first- and second-generation cryoballoons in PAF ablation, using cryoballoon size tailored to pulmonary vein anatomy. METHODS: In this single-centre study, we included the last 50 consecutive PAF patients who underwent cryoballoon-based pulmonary vein isolation using the first-generation cryoballoon (CB-1) and the first 50 patients using the second-generation cryoballoon (CB-2)...
October 2017: Archives of Cardiovascular Diseases
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