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https://www.readbyqxmd.com/read/29229209/randomized-double-blind-placebo-controlled-dose-escalation-study-investigation-of-the-safety-pharmacokinetics-and-antihyperalgesic-activity-of-l-4-chlorokynurenine-in-healthy-volunteers
#1
Mark Wallace, Alexander White, Kathy A Grako, Randal Lane, Allen Jo Cato, H Ralph Snodgrass
BACKGROUND AND AIMS: Neuropathic pain is a significant medical problem needing more effective treatments with fewer side effects. Overactive glutamatergic transmission via N-methyl-d-aspartate receptors (NMDARs) are known to play a role in central sensitization and neuropathic pain. Although ketamine, a NMDAR channel-blocking antagonist, is often used for neuropathic pain, its side-effect profile and abusive potential has prompted the search for a safer effective oral analgesic. A novel oral prodrug, AV-101 (l-4 chlorokynurenine), which, in the brain, is converted into one of the most potent and selective GlyB site antagonists of the NMDAR, has been demonstrated to be active in animal models of neuropathic pain...
October 2017: Scandinavian Journal of Pain
https://www.readbyqxmd.com/read/29229104/heart-rate-and-risk-of-death-among-patients-with-pulmonary-hypertension-a-12-lead-ecg-analysis
#2
Helene Bouchery-Bardet, Christian Creveuil, Fabrice Bauer, Farzin Beygui, Laure Champ-Rigot, Eric Saloux, Fabien Labombarda, Vincent Roule, Rémi Sabatier, Damien Legallois, Gérard Zalcman, Emmanuel Bergot, Paul Milliez
BACKGROUND: Despite the emergence of new therapies, Pulmonary Hypertension (PH) still has a high mortality. Several clinical, echocardiographic, biological or hemodynamic prognostic factors have been identified but are of limited predictive value for survival. We aimed to assess whether heart rate (HR) and all ECG abnormalities measured on a 12-lead ECG may help to better identify patients at high risk of death in this population. METHODS AND RESULTS: 296 patients followed in a registry were included with all types of PH, except group 2 of the WHO clinical classification...
November 2017: Respiratory Medicine
https://www.readbyqxmd.com/read/29226502/s-r-difference-in-v1-v2-is-a-novel-criterion-for-differentiating-the-left-from-right-ventricular-outflow-tract-arrhythmias
#3
Onur Kaypakli, Hasan Koca, Durmus Yıldıray Sahin, Fadime Karataş, Suleyman Ozbicer, Mevlüt Koç
AIM: The correct estimation of the VA origin as RVOT or LVOT results in reduced ablation duration reduced radiation exposure and decreased number of vascular access. In our study, we aimed to detect the predictive value of S-R difference in V1-V2 for differentiating the left from right ventricular outflow tract arrhythmias. METHODS: We included 123 patients with symptomatic frequent premature ventricular outflow tract contractions who underwent successful catheter ablation (70 male, 53 female; mean age 46...
December 10, 2017: Annals of Noninvasive Electrocardiology
https://www.readbyqxmd.com/read/29220423/tpeak-tend-interval-during-therapeutic-hypothermia-can-predict-upcoming-ventricular-fibrillation-in-subjects-with-aborted-arrhythmic-sudden-cardiac-death-3-years-follow-up-results
#4
Namsik Yoon, Seo Hong, Aaron Glass, Sung Soo Kim, Min Chul Kim, Jae Yeong Cho, Ki Hong Lee, Doo Sun Sim, Hyun Ju Yoon, Kye Hun Kim, Young Joon Hong, Hyung Wook Park, Ju Han Kim, Youngkeun Ahn, Myung Jeong, Jong Chun Park, Jeong Gwan Cho
Aims: Prolonged Tpeak-Tend interval has been shown to be markers of arrhythmogenesis in various cardiac disorders. However, its dynamicity is one of the obstacles to predict fatal ventricular arrhythmia. This study investigated whether Tpeak-Tend interval during therapeutic hypothermia (TH) is associated with ventricular fibrillation (VF) inducibility and clinical arrhythmia in subjects with aborted arrhythmic sudden cardiac death (SCD). Methods and results: The study group included 31 patients (24 males, age 39...
December 1, 2017: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/29212469/orthogonal-p-wave-morphology-is-affected-by-intra-atrial-pressures
#5
Richard Petersson, J Gustav Smith, David A Larsson, Öyvind Reitan, Jonas Carlson, Pyotr Platonov, Fredrik Holmqvist
BACKGROUND: It has previously been shown that the morphology of the P-wave neither depends on atrial size in healthy subjects with physiologically enlarged atria nor on the physiological anatomical variation in transverse orientation of the left atrium. The present study aimed to investigate if different pressures in the left and right atrium are associated with different P-wave morphologies. METHODS: 38 patients with isolated, increased left atrial pressure, 51 patients with isolated, increased right atrial pressure and 76 patients with biatrially increased pressure were studied...
December 6, 2017: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/29211124/association-of-oral-lichen-planus-and-electrocardiographic-p-wave-dispersion-an-original-research
#6
R Aditi, S Sathasivasubramanian, M Emmanuel Bhaskar
Lichen planus (LP) is considered to be a T-cell-mediated inflammatory disorder. Inflammation is considered to produce disturbances of lipid metabolism which may affect the myocardium. Increased P-Wave Dispersion (PWD) is demonstrated as an independent risk factor for developing atrial fibrillation (AF). Hence the present study has been conducted to explore the possible relationship of oral lichen planus (OLP) with AF by the evaluation of PWD. Twelve-lead electrocardiographs (ECG) were obtained from 45 OLP patients and 45 age and gender-matched healthy controls...
November 2017: Brazilian Dental Journal
https://www.readbyqxmd.com/read/29207228/-clinical-practice-for-the-diagnosis-of-cardiac-arrhythmias-in-patients-on-renal-replacement-therapy-data-from-a-lombard-survey
#7
Simonetta Genovesi, Elisa Nava, Alice Pasa, Enzo Corghi, Patrizia Ondei, Elisabetta Marta, Antonio Bellasi, Fabio Malberti, Ugo Teatini, Carlo Maria Guastoni, Leonardo Spatola, Maria Carmen Luise, Renza Tiboldo, Silvio Bertoli, Piergiorgio Messa, Maria Doria, Maurizio Gallieni, Mario Cozzolino, Donatella Spotti, Valeria Sala, Elisabetta Sironi, Giuseppe Boriani
Among dialysis patients, 40% of deaths are due to cardiovascular causes, and 60% of cardiac deaths are due to an arrhythmia. The purpose of this survey, carried out with the organizational support of the Lombard Section of the Italian Society of Nephrology, is to evaluate the frequency and mode of use of non-invasive instruments for the diagnosis of cardiac arrhythmias in the dialysis centers of Lombardy. Information on the prevalence and type of cardiac devices at December 1, 2016 in this population was also required...
December 5, 2017: Giornale Italiano di Nefrologia: Organo Ufficiale Della Società Italiana di Nefrologia
https://www.readbyqxmd.com/read/29203574/blunt-chest-trauma-a-clinical-chameleon
#8
REVIEW
Kaveh Eghbalzadeh, Anton Sabashnikov, Mohamed Zeriouh, Yeong-Hoon Choi, Alexander C Bunck, Navid Mader, Thorsten Wahlers
The incidence of blunt chest trauma (BCT) is greater than 15% of all trauma admissions to the emergency departments worldwide and is the second leading cause of death after head injury in motor vehicle accidents. The mortality due to BCT is inhomogeneously described ranging from 9% to 60%. BCT is commonly caused by a sudden high-speed deceleration trauma to the anterior chest, leading to a compression of the thorax. All thoracic structures might be injured as a result of the trauma. Complex cardiac arrhythmia, heart murmurs, hypotension, angina-like chest pain, respiratory insufficiency or distention of the jugular veins may indicate potential cardiac injury...
December 4, 2017: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/29203211/qtc-interval-cardiovascular-events-and-mortality-in-patients-with-atrial-fibrillation
#9
Andreas Reusser, Steffen Blum, Stefanie Aeschbacher, Lucien Eggimann, Peter Ammann, Paul Erne, Giorgio Moschovitis, Marcello Di Valentino, Dipen Shah, Jürg Schläpfer, Samuel Manser, Tobias Reichlin, Michael Kühne, Christian Sticherling, Stefan Osswald, David Conen
BACKGROUND: A longer QTc interval has been associated with more adverse cardiovascular events and death in the general population. Little evidence is available on these relationships among patients with atrial fibrillation (AF). METHODS: We performed a prospective observational multicenter cohort study of 1413 patients with AF. A resting 12‑lead electrocardiogram (ECG) was performed at baseline. QT interval was corrected for heart rate using the Bazett formula (QTc)...
November 24, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/29203081/semi-automated-qrs-score-as-a-predictor-of-survival-in-crt-treated-patients-with-strict-left-bundle-branch-block
#10
C Reitan, U Chaudhry, B Atwater, J Jacobsson, J P Couderc, X Xia, J Carlson, P G Platonov, R Borgquist
BACKGROUND: Cardiac Resynchronization Therapy (CRT) is widely used for treating selected heart failure patients, but patients with myocardial scar respond worse to treatment. The Selvester QRS scoring system estimates myocardial scar burden using 12-lead ECG. This study's objective was to investigate the scores correlation to mortality in a CRT population. METHODS AND RESULTS: Data on consecutive CRT patients was collected. 401 patients with LBBB and available ECG data were included in the study...
November 15, 2017: Journal of Electrocardiology
https://www.readbyqxmd.com/read/29202647/swallow-presyncope-in-an-athletic-patient-caused-by-third-degree-atrioventricular-block
#11
Axel Van Damme, Tine De Backer, Philippe Vanderheeren
Introduction Swallow syncope is a neurally mediated syncope. Multiple causes have been described in literature. A rare cause is arrhythmias. Only a limited amount of cases present the association of swallow syncope and third degree AV-block. Case presentation A 39-year-old man presented with episodes of presyncope while eating. Further medical history, physical examination, resting 12-lead ECG, cyclo-ergometry, transthoracic echocardiography and MRI of the heart were normal. 24 h Holter monitoring demonstrated high-grade third-degree atrioventricular (AV) block...
December 5, 2017: Acta Clinica Belgica
https://www.readbyqxmd.com/read/29201955/the-relationship-of-st-segment-changes-in-lead-avr-with-outcomes-after-myocardial-infarction-a-cross-sectional-study
#12
Mohammad Reza Beyranvand, Mohammad Assadpour Piranfar, Mohammadreza Mobini, Mehdi Pishgahi
Introduction: Among the 12 leads studied in electrocardiography (ECG), lead aVR can be considered as the most forgotten part of it since no attention is paid to it as the mirror image of other leads. Therefore, the present study has been designed with the aim of evaluating the prevalence of ST segment changes in lead aVR and its relationship with the outcome of these patients. Methods: In this retrospective cross sectional study medical profiles of patients who had presented to emergency department with the final diagnosis of myocardial infarction (MI) in a 4-year period were evaluated regarding changes of ST segment in lead aVR and its relationship with in-hospital mortality, the number of vessels involved, infarct location and cardiac ejection fraction...
2017: Emergency (Tehran, Iran)
https://www.readbyqxmd.com/read/29200022/relationship-between-ventricular-arrhythmias-conduction-disorders-and-myocardial-fibrosis-in-patients-with-systemic-sclerosis
#13
Lucian Muresan, Irinel Oancea, Razvan Ovidiu Mada, Ana Petcu, Cristina Pamfil, Crina Muresan, Mirela Rinzis, Dana Pop, Dumitru Zdrenghea, Simona Rednic
BACKGROUND: Delayed-enhancement magnetic resonance imaging (DE-MRI) is a noninvasive diagnostic tool able to identify myocardial fibrosis. In patients with scleroderma, its relationship with arrhythmias and conduction disorders has not been fully explored. OBJECTIVES: The aim of this study was to evaluate the possible correlations between ventricular arrhythmias, conduction disorders, and myocardial fibrosis in patients with systemic sclerosis. METHODS: Thirty-six patients with diffuse or limited cutaneous scleroderma underwent 12-lead electrocardiogram (ECG), 24-hour Holter ECG monitoring, transthoracic echocardiography, and cardiac DE-MRI, with gadolinium administration in 33 patients...
December 1, 2017: Journal of Clinical Rheumatology: Practical Reports on Rheumatic & Musculoskeletal Diseases
https://www.readbyqxmd.com/read/29192587/the-proportion-of-asymptomatic-recurrence-after-catheter-ablation-of-atrial-fibrillation-in-patients-with-a-pacemaker-for-sick-sinus-syndrome
#14
Yuki Osaka, Masateru Takigawa, Atsushi Takahashi, Taishi Kuwahara, Kenji Okubo, Yoshihide Takahashi, Yasuaki Tanaka, Naohiko Kawaguchi, Kazuya Yamao, Yuji Watari, Emiko Nakashima, Jun Nakajima, Katsumasa Takagi, Tadashi Fujino, Shigeki Kimura, Hiroyuki Hikita, Kenzo Hirao, Mitsuaki Isobe
BACKGROUND: Catheter ablation (CA) of paroxysmal atrial fibrillation (PAF) is an effective treatment. However, the frequency of asymptomatic AF recurrence after CA in patients with PAF and sick sinus syndrome (SSS) is not clear. The aim of this study was to elucidate the real AF recurrence after CA in patients with PAF and a pacemaker for SSS. METHODS AND RESULTS: Fifty-one consecutive patients (mean age 66.6 ± 7.0 years, male 34) with PAF and SSS and pacemakers underwent CA...
September 2017: Indian Pacing and Electrophysiology Journal
https://www.readbyqxmd.com/read/29183415/the-pre-participation-screening-in-young-athletes-which-protocol-do-we-need-exactly
#15
İbrahim I Çetin, Filiz Ekici, Ayşe E Kibar, Murat Sürücü, Ali Orgun
The aim was to assess the utility and feasibility of a comprehensive cardiac screening protocol in young athletes before participation in sports. A total of 380 athletes referring before participation in sports, between April, 2014 and April, 2015, were included in this study. The mean age was 12.4 years. A screening protocol has been applied to all, including personal and family history, physical examination, 12-lead electrocardiography, transthoracic echocardiography, 24-hour rhythm Holter analysis, and treadmill exercise test...
November 29, 2017: Cardiology in the Young
https://www.readbyqxmd.com/read/29174248/electrocardiographic-characteristics-in-young-male-patients-with-left-primary-spontaneous-pneumothorax-estimated-by-the-collins-equation
#16
Pang-Yen Liu, Yen-Po Lin, Yi-Hwei Li, Zhi-Wei Su, Chih-Lu Han, Shih-Chung Huang, Chin-Sheng Lin, Fan-Chun Meng, Hsien-Tsai Wu, Gen-Min Lin
OBJECTIVE: To investigate the 12-lead surface electrocardiographic (ECG) findings in young male patients with left primary spontaneous pneumothorax (PSP) estimated by the Collins equation. METHODS: From 2003 through 2008, 60 young male patients who had left PSP and 61 age-matched unaffected males were included for 12-lead ECG analyses. The PSP size was estimated by the Collins equation. Those with left PSP were divided into two groups: 1) large PSP ≥30% (n=37), and 2) small PSP <30% (n=23)...
November 2017: Indian Heart Journal
https://www.readbyqxmd.com/read/29174184/competitive-interaction-between-chronic-obstructive-pulmonary-disease-and-cha2ds2-vasc-score-in-predicting-incident-atrial-fibrillation
#17
Maria Perticone, Angela Sciacqua, Giovanni Tripepi, Sofia Miceli, Salvatore Corrao, Giorgio Sesti, Francesco Perticone
BACKGROUND: Chronic obstructive pulmonary disease (COPD) is a leading cause of morbidity and mortality, and an emerging risk factor for atrial fibrillation (AF). CHADS2 and CHA2DS2-VASc scores are significantly associated with incident AF independently of other risk factors. The aim of this study was to demonstrate a possible interaction between COPD and CHA2DS2-VASc in predicting incident AF. METHODS: This observational prospective cohort study included 4322 Caucasians with cardiovascular risk factors, stratified by CHA2DS2-VASc score (>2 vs <2) and presence/absence of COPD...
November 20, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/29174099/smartphone-ecg-for-evaluation-of-st-segment-elevation-myocardial-infarction-stemi-design-of-the-st-leuis-international-multicenter-study
#18
Alejandro Barbagelata, Charles F Bethea, Harry W Severance, Robert J Mentz, David Albert, Gregory W Barsness, Viet T Le, Jeffrey L Anderson, T Jared Bunch, Frank Yanowitz, Benjamin Chisum, Brianna S Ronnow, Joseph B Muhlestein
In patients experiencing an ST-elevation myocardial infarction (STEMI), rapid diagnosis and immediate access to reperfusion therapy leads to optimal clinical outcomes. The rate-limiting step in STEMI diagnosis is the availability and performance of a 12-lead ECG. Recent technology has provided access to a reliable means of obtaining an ECG reading through a smartphone application (app) that works with an attachment providing all 12-leads of a standard ECG system. The ST LEUIS study was designed to validate the smartphone ECG app and its ability to accurately assess the presence or absence of STEMI in patients presenting with chest pain compared with the gold standard 12-lead ECG...
October 19, 2017: Journal of Electrocardiology
https://www.readbyqxmd.com/read/29169886/a-potential-diagnostic-pitfall-in-acute-chest-pain-massive-pulmonary-embolism-mimicking-acute-st-elevation-myocardial-infarction
#19
Ya-Wen Lu, Yi-Lin Tsai, Chun-Chin Chang, Po-Hsun Huang
BACKGROUND: Pulmonary embolism (PE) represents a clinical challenge for clinicians because of nonspecific presentations, including dyspnea, chest pain, and tachycardia. The immediate 12-lead electrocardiogram (ECG) is commonly used to facilitate differential diagnosis of acute chest pain. Although relative rare, massive pulmonary embolism could induce ST segment elevation and mimic acute myocardial infarction. CASE PRESENTATION: We present a challenging scenario that ECG showed ST segment elevation, nevertheless, urgent coronary angiogram revealed non-obstructive coronary artery disease...
November 20, 2017: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/29168986/skin-aging-parameters-a-window-to-heart-block
#20
Hisham Samir Roshdy, Mohammad Hassan Soliman, Ibtesam Ibrahim El-Dosouky, Soheir Ghonemy
BACKGROUND: Skin acts as a mirror to the internal state of the body. HYPOTHESIS: We tried to find the relation between skin aging parameters and the incidence of degenerative AV block. METHODS: This study included 97 patients divided into 2 groups; group D comprised 49 patients with advanced-degree AV block, and group C comprised the 48 matched control group. All were subjected to full history taking, thorough clinical examination, calculation of intrinsic skin aging score, and resting 12-lead surface electrocardiography (ECG)...
November 23, 2017: Clinical Cardiology
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