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4d echocardiography

Douglas Wildes, Warren Lee, Bruno Haider, Scott Cogan, Krishnakumar Sundaresan, David Mills, Christopher Yetter, Patrick Hart, Christopher Haun, Mikael Concepcion, Johan Kirkhorn, Marc Bitoun
We developed a 2.5 x 6.6 mm 2D array transducer with integrated transmit/receive ASIC for 4D ICE (real-time 3D IntraCardiac Echocardiography) applications. The ASIC and transducer design were optimized so that the high voltage transmit, low-voltage TGC (time-gain control) and preamp, subaperture beamformer, and digital control circuits for each transducer element all fit within the 0.019 mm2 area of the element. The transducer assembly was deployed in a 10 Fr (3.3 mm diameter) catheter, integrated with a GE Vivid1 E9 ultrasound imaging system, and evaluated in three pre-clinical studies...
October 12, 2016: IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control
Kelly Jarvis, Marleen Vonder, Alex J Barker, Susanne Schnell, Michael Rose, James Carr, Joshua D Robinson, Michael Markl, Cynthia K Rigsby
BACKGROUND: Peak velocity measurements are used to evaluate the significance of stenosis in patients with transposition of the great arteries after the arterial switch operation (TGA after ASO). 4D flow cardiovascular magnetic resonance (CMR) provides 3-directional velocity encoding and full volumetric coverage of the great arteries and may thus improve the hemodynamic evaluation in these patients. The aim of this study was to compare peak velocities measured by 4D flow CMR with 2D phase contrast (PC) CMR and the gold standard Doppler echocardiography (echo) in patients with TGA after ASO...
2016: Journal of Cardiovascular Magnetic Resonance
Michael Markl, Daniel C Lee, Nicholas Furiasse, Maria Carr, Charles Foucar, Jason Ng, James Carr, Jeffrey J Goldberger
BACKGROUND: Atrial 4D flow magnetic resonance imaging was used for the characterization of left atrial (LA) and left atrial appendage (LAA) flow dynamics in patients with atrial fibrillation (AF). METHODS AND RESULTS: 4D flow magnetic resonance imaging measured in vivo 3D blood flow velocities in 60 AF patients and 15 controls. Anatomic maps of LA and LAA stasis and velocity were calculated to quantify atrial peak velocity, mean velocity, and stasis (velocities <0...
September 2016: Circulation. Cardiovascular Imaging
Guyue Hu, Ying Zhang, Miao Fan, Meilian Wang, Faiza Amber Siddiqui, Yu Wang, Wei Sun, Feifei Sun, Dongyu Zhang, Wenjia Lei, Xue Sun
BACKGROUND: Prenatal diagnosis of cardiac valve anomalies challenged most screening sonographers. The purpose of the study was to evaluate the use of four-dimensional echocardiography with spatiotemporal image correlation (4DSTIC) in detecting normal and abnormal fetal cardiac valves. METHODS: Forty-three cases of confirmed cardiac valve anomalies identified by two-dimensional echocardiography (2DE) were retrospectively reviewed in this study. Additional 121 confirmed normal fetuses were included as controls...
August 22, 2016: Echocardiography
M Hamzaoui, C Roche, A Lejeune, V Brunel, V Richard, J Bellien, D Guerrot
OBJECTIVE: Cardiovascular (CV) events are more prevalent in chronic kidney disease (CKD) than in the general population, being the main cause of morbi-mortality. The aim of this project is to study the CV impact of the increase in the bioavailability of epoxyeicosatrienoic acids (EETs) by inhibiting soluble epoxide hydrolase (sEH) in the 5/6 nephrectomy model in 129/Sv mice. DESIGN AND METHOD: 5/6 Nx mice were treated with the sEH inhibitor t-AUCB, a diuretic (amiloride), or placebo for 10 weeks...
September 2016: Journal of Hypertension
Cecilia Linde, Maria J Eriksson, Camilla Hage, Håkan Wallén, Bengt Persson, Matthias Corbascio, Joakim Lundeberg, Eva Maret, Martin Ugander, Hans Persson
AIMS: Heart failure (HF) with preserved (HFpEF) or reduced (HFrEF) ejection fraction is associated with poor prognosis and quality of life. While the incidence of HFrEF is declining and HF treatment is effective, HFpEF is increasing, with no established therapy. PREFERS Stockholm is an epidemiological study with the aim of improving clinical care and research in HF and to find new targets for drug treatment in HFpEF (
July 7, 2016: European Journal of Heart Failure
Eric J Keller, S Chris Malaisrie, Jane Kruse, Patrick M McCarthy, James C Carr, Michael Markl, Alex J Barker, Jeremy D Collins
OBJECTIVES: Previous work suggests that aortic root and valve prostheses alter blood flow patterns in the ascending aorta, creating aberrant haemodynamics compared with those of healthy volunteers. Various valve designs have been proposed to better restore physiological haemodynamics. In this study, magnetic resonance imaging (MRI) was used to non-invasively assess three-dimensional (3D) ascending aortic haemodynamics after aortic root replacement (ARR) with a mechanical valved conduit postulated to create less turbulent blood flow...
September 2016: Interactive Cardiovascular and Thoracic Surgery
Michael J Rose, Kelly Jarvis, Varun Chowdhary, Alex J Barker, Bradley D Allen, Joshua D Robinson, Michael Markl, Cynthia K Rigsby, Susanne Schnell
PURPOSE: To test the feasibility and effectiveness of using maximum intensity plots (MIPs) based on 4D flow magnetic resonance imaging (MRI) velocity data to assess systolic peak velocities in a cohort of bicuspid aortic valve (BAV) patients. MATERIALS AND METHODS: 4D flow MRI at 1.5T was performed on 51 BAV patients. MIPs were generated from the 4D flow MRI velocity data and used by two users to determine peak velocities in three regions of interest (ROIs): ascending aorta (AAo), aortic arch, and descending aorta...
May 18, 2016: Journal of Magnetic Resonance Imaging: JMRI
Ran Chen, Meihua Zhu, David J Sahn, Muhammad Ashraf
BACKGROUND: The aim of this study is to assess the accuracy and feasibility of left ventricular systolic function determined by four-dimensional echocardiography (4DE). METHODS: Latex balloons were sewn into the left ventricle (LV) of 20 freshly harvested pig hearts which were then passively driven by a pulsatile pump apparatus. Global longitudinal strain (GLS), global circumferential strain (GCS), global area strain (GAS) and left ventricular ejection fraction (LVEF) derived from 4DEand two-dimensional echocardiography (2DE)-derived LVEF were quantified at different stroke volumes (SV) 30-70 ml and correlated with sonomicrometry data...
2016: PloS One
B M E Adriaanse, J M G van Vugt, M C Haak
Congenital heart diseases (CHD) are the most commonly overlooked lesions in prenatal screening programs. Real-time two-dimensional ultrasound (2DUS) is the conventionally used tool for fetal echocardiography. Although continuous improvements in the hardware and post-processing software have resulted in a good image quality even in late first trimester, 2DUS still has its limitations. Four-dimensional ultrasound with spatiotemporal image correlation (STIC) is an automated volume acquisition, recording a single three-dimensional (3D) volume throughout a complete cardiac cycle, which results in a four-dimensional (4D) volume...
September 2016: Journal of Perinatology: Official Journal of the California Perinatal Association
Antonello D'Andrea, Donato Mele, Eustachio Agricola, Enrica Pezzullo, Matteo Cameli, Andrea Rossi, Roberta Esposito, Giuseppina Novo, Sergio Mondillo, Roberta Montisci, Sabina Gallina, Eduardo Bossone, Maurizio Galderisi
No abstract text is available yet for this article.
March 1, 2016: International Journal of Cardiology
Alison M Pouch, Benjamin M Jackson, Paul A Yushkevich, Joseph H Gorman, Robert C Gorman
No abstract text is available yet for this article.
September 2015: Annals of Cardiothoracic Surgery
Judith Eskofier, Patrick Wefstaedt, Martin Beyerbach, Ingo Nolte, Stephan O Hungerbühler
BACKROUND: Real-time three-dimensional echocardiography (RT3DE) enables accurate volume determination of the left ventricle (LV), since measurements in foreshortened depicted views are avertable. Different analyzing programs are available for this RT3DE. The commonly used semi-automatic software 4D-AutLVQ™ showed underestimation of LV volumes in comparison with CMRI in healthy anesthetized dogs (Am J Vet Res 74(9):1223-1230, 2013). TomTec 4D LV-Function™ is an offline analysis program for morphological and functional analyses of the left ventricle by using manual measurement optimization, showing excellent agreement with CMRI in human medicine (Echocardiography 27(10):1263-1273, 2010; Eur J Echocardiogr 11(4):359-368, 2010; Echocardiography 24(9):967-974, 2007)...
2015: BMC Veterinary Research
Brett E Fenster, James Browning, Joyce D Schroeder, Michal Schafer, Chris A Podgorski, Jamie Smyser, Lori J Silveira, J Kern Buckner, Jean R Hertzberg
Right ventricular diastolic dysfunction (RVDD) is an important prognostic indicator in pulmonary arterial hypertension (PAH). RV vortex rings have been observed in healthy subjects, but their significance in RVDD is unknown. Vorticity, the local spinning motion of an element of fluid, may be a sensitive measure of RV vortex dynamics. Using four-dimensional (4D) flow cardiac magnetic resonance imaging (CMR), we investigated the relationship between right heart vorticity with echocardiographic indexes of RVDD...
September 15, 2015: American Journal of Physiology. Heart and Circulatory Physiology
Ruqayya Awan, Kashif Rajpoot
BACKGROUND: Ultrasound images are difficult to segment because of their noisy and low contrast nature which makes it challenging to extract the important features. Typical intensity-gradient based approaches are not suitable for these low contrast images while it has been shown that the local phase based technique provides better results than intensity based methods for ultrasound images. The spatial feature extraction methods ignore the continuity in the heart cycle and may also capture spurious features...
September 2015: Computers in Biology and Medicine
Olga Gómez, Iris Soveral, Mar Bennasar, Fatima Crispi, Narcis Masoller, Edda Marimon, Joaquim Bartrons, Eduard Gratacós, Josep M Martinez
OBJECTIVES: To report on the accuracy of fetal echocardiography in the distinction between truncus arteriosus communis (CAT) and pulmonary atresia with ventricular septal defect (PA-VSD) and to describe the association with extracardiac and chromosomal anomalies. METHODS: This was a retrospective study on 31 fetuses with a single arterial trunk overriding a VSD with a nonidentifiable right ventricle outflow tract with anterograde flow. Data on the type of cardiac defect, gestational age, characteristics of the arterial trunk valve, presence of additional vascular, chromosomal and extracardiac abnormalities and postnatal outcome were obtained...
2016: Fetal Diagnosis and Therapy
Dongyu Zhang, Ying Zhang, Weidong Ren, Feifei Sun, Yajun Guo, Wei Sun, Yu Wang, Liping Huang, Ailu Cai
BACKGROUND: Fetal interrupted aortic arch (IAA) is a rare cardiac anomaly and its prenatal diagnosis is challenging. The purpose of our report is to evaluate the use of two-dimensional echocardiography (2DE) and 4D echocardiography with B-flow imaging and spatiotemporal image correlation (4D BF-STIC) in detecting IAA type A (IAA-A). MATERIALS & METHODS: Twenty-three cases of confirmed IAA-A identified by fetal echocardiography were involved in the study. The fetal echocardiography image data were reviewed to analyze the ratio of right ventricle to left ventricle (RV/LV) diameter, the ratio of main pulmonary artery to ascending aorta (MPA/AAO) diameter, and the correlation of RV/LV diameter ratio and size of ventricular septal defect (VSD)...
January 2016: Echocardiography
Shu-Wen Zhong, Yu-Qi Zhang, Li-Jun Chen, Shan-Shan Wang, Wei-Hua Li
BACKGROUND: Real time three-dimensional echocardiography (RT3DE) provides a reliable analysis of left ventricular (LV) volume. Despite a wide spectrum of tracking algorithms presently available, which software is most suitable for evaluating functional single left ventricle (FLSV) is unknown. Herein, we compared two of the most commonly used 3DE algorithms for quantification of LV volumes in the pediatric population with FLSV. METHODS: Thirty-six children with FLSV were prospectively enrolled...
October 2015: Echocardiography
Simone Gorressen, Manuel Stern, Annette M van de Sandt, Miriam M Cortese-Krott, Jan Ohlig, Tienush Rassaf, Axel Gödecke, Jens W Fischer, Gerd Heusch, Marc W Merx, Malte Kelm
PURPOSE: Nitric oxide (NO) is constitutively produced and released from the endothelium and several blood cell types by the isoform 3 of the NO synthase (NOS3). We have shown that NO protects against myocardial ischemia/reperfusion (I/R) injury and that depletion of circulating NOS3 increases within 24 h of ischemia/reperfusion the size of myocardial infarction (MI) in chimeric mice devoid of circulating NOS3. In the current study we hypothesized that circulating NOS3 also affects remodeling of the left ventricle following reperfused MI...
2015: PloS One
Andrea Madeo, Paolo Piras, Federica Re, Stefano Gabriele, Paola Nardinocchi, Luciano Teresi, Concetta Torromeo, Claudia Chialastri, Michele Schiariti, Geltrude Giura, Antonietta Evangelista, Tania Dominici, Valerio Varano, Elisabetta Zachara, Paolo Emilio Puddu
The assessment of left ventricular shape changes during cardiac revolution may be a new step in clinical cardiology to ease early diagnosis and treatment. To quantify these changes, only point registration was adopted and neither Generalized Procrustes Analysis nor Principal Component Analysis were applied as we did previously to study a group of healthy subjects. Here, we extend to patients affected by hypertrophic cardiomyopathy the original approach and preliminarily include genotype positive/phenotype negative individuals to explore the potential that incumbent pathology might also be detected...
2015: PloS One
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