Sara Hakim, Aakanksha Jain, Veselina Petrova, Jonathan Indajang, Riki Kawaguchi, Qing Wang, Elif Sude Duran, Drew Nelson, Stuart S Adamson, Caitlin Greene, Clifford J Woolf
Diabetic peripheral neuropathy (DPN) is a common complication of diabetes, causing sensory loss and debilitating neuropathic pain 1,2 . Although the onset and progression of DPN have been linked with dyslipidemia and hyperglycemia 3 , the contribution of inflammation in the pathogenesis of DPN has not been investigated. Here, we use a High Fat High Fructose Diet (HFHFD) to model DPN and the diabetic metabolic syndrome in mice. Diabetic mice develop persistent heat hypoalgesia after three months, but a reduction in epidermal skin innervation only manifests at 6 months...
January 30, 2024: bioRxiv