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https://www.readbyqxmd.com/read/28335876/child-abuse-neural-structure-and-adolescent-psychopathology-a-longitudinal-study
#1
Daniel S Busso, Katie A McLaughlin, Stephanie Brueck, Matthew Peverill, Andrea L Gold, Margaret A Sheridan
OBJECTIVE: Child abuse exerts a deleterious impact on a broad array of mental health outcomes. However, the neurobiological mechanisms that mediate this association remain poorly characterized. Here, we use a longitudinal design to prospectively identify neural mediators of the association between child abuse and psychiatric disorders in a community sample of adolescents. METHOD: Structural magnetic resonance imaging (MRI) data and assessments of mental health were acquired for 51 adolescents (aged 13-20; M=16...
April 2017: Journal of the American Academy of Child and Adolescent Psychiatry
https://www.readbyqxmd.com/read/28333546/pharmacokinetics-and-safety-of-vortioxetine-in-pediatric-patients
#2
Robert L Findling, Adelaide S Robb, Melissa DelBello, Michael Huss, Nora McNamara, Elias Sarkis, Russell Scheffer, Lis H Poulsen, Grace Chen, Ole Michael Lemming, Johan Areberg, Philippe Auby
OBJECTIVE: The primary objectives of this study were to evaluate the pharmacokinetics (PK) and tolerability of single and multiple doses of vortioxetine in children and adolescents with a depressive or anxiety disorder and to provide supportive information for appropriate dosing regimens for pediatric clinical trials. METHODS: This prospective, open-label, multinational, multisite, multiple-dose trial enrolled 48 patients (children and adolescents; 1:1 ratio) divided into 8 cohorts (4 adolescent and 4 child), with each cohort including 6 patients...
March 23, 2017: Journal of Child and Adolescent Psychopharmacology
https://www.readbyqxmd.com/read/28326741/the-impact-of-childhood-adversities-on-anxiety-and-depressive-disorders-in-adulthood
#3
(no author information available yet)
OBJECTIVES: The childhood adversities model is generally accepted as a predictor of adult psychopathology vulnerability. It stems from child development theories, but the question remains as of how well solid research supports it. The aim of this article is to give a review of the studies concerning childhood adversities and their impact on the development of anxiety disorders and major depressive disorder in adulthood. METHOD: A computerized search of the MEDLINE database of publications up to 31 March 2016 was done, using the keywords "childhood adversities, abuse, maltreatment, bullying" and "anxiety disorders, depressive disorder"...
December 22, 2016: Neuro Endocrinology Letters
https://www.readbyqxmd.com/read/28326047/preventing-internalizing-problems-in-young-children-a-randomized-controlled-trial-of-the-feelings-and-friends-year-3-program-with-a-motor-skills-component
#4
Ruhamah G Tennant, Katie K Martin, Rosanna Rooney, Sharinaz Hassan, Robert T Kane
Anxiety and depression are common mental health problems experienced by children in Australia. The impact of these internalizing disorders is pervasive, affecting many areas of life. By the time problems have been detected in children they can be severe in nature and harder to treat. Hence, early intervention is of utmost importance. Despite the existence of numerous prevention programs for children, there is limited empirical evidence for a program that has an impact on symptoms of both anxiety and depression...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28325387/-the-efficacy-of-care-as-perceived-by-adolescents-presenting-anxiety-based-school-refusal
#5
REVIEW
Jordan Sibeoni, Massimiliano Orri, Sophie Campredon, Anne Revah-Levy
School refusal is a complex disorder which is sometimes difficult to treat and which has potentially significant consequences on the child's schooling and mental health. A qualitative study was carried out in 2014-2015 on the feelings of adolescents and their parents with regard to the efficacy of care. The results show that, while adolescents and parents do not share the same representation of the care objectives, they agree on the therapeutic levers identified as been effective: time and relationships.
March 2017: Soins. Pédiatrie, Puériculture
https://www.readbyqxmd.com/read/28302701/prevalence-of-antenatal-and-postnatal-anxiety-systematic-review-and-meta-analysis
#6
REVIEW
Cindy-Lee Dennis, Kobra Falah-Hassani, Rahman Shiri
BackgroundMaternal anxiety negatively influences child outcomes. Reliable estimates have not been established because of varying published prevalence rates.AimsTo establish summary estimates for the prevalence of maternal anxiety in the antenatal and postnatal periods.MethodWe searched multiple databases including MEDLINE, Embase, and PsycINFO to identify studies published up to January 2016 with data on the prevalence of antenatal or postnatal anxiety. Data were extracted from published reports and any missing information was requested from investigators...
March 16, 2017: British Journal of Psychiatry: the Journal of Mental Science
https://www.readbyqxmd.com/read/28300707/psychiatric-and-psychological-impact-of-surgery-while-awake-in-children-for-resection-of-brain-tumors
#7
Elise Riquin, Mickael Dinomais, Jean Malka, Thierry Lehousse, Philippe Duverger, Philippe Menei, Matthieu Delion
Intraoperative direct stimulation during surgery while awake is considered to be the gold standard for identifying eloquent cortical sites. Only a few studies have referenced the psychological impact of this event in the pediatric population. OBJECTIVE: The aim of this clinical study is to present the psychological aspects of surgery while awake in children. We question the psychiatric contraindications and age limits, and the impact on children, with particular attention to the psychological conditioning and experience of these patients...
March 11, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28299303/the-efficacy-of-augment-of-d-cycloserine-and-cognitive-behavioral-therapy-on-adolescent-with-one-type-of-anxiety-disorders-a-double-blind-randomized-controlled-trial
#8
Soroor Arman, Ali Soheilimehr, Mohammad Reza Maracy
BACKGROUND: This study was designed to investigating the effect of combining D-cycloserine (DCS) and cognitive-behavioral therapy (CBT) on adolescent with at least one type of anxiety disorders. MATERIALS AND METHODS: The present study was conducted as a double-blind randomized controlled trial on 36 adolescent with anxiety disorders. Patients were assessed in two groups. In addition to 4 sessions of weekly CBT in both groups; case group, received a 50-mg DCS capsules, control group, received Placebo daily for a month...
2017: Advanced Biomedical Research
https://www.readbyqxmd.com/read/28286488/evaluation-of-mother-child-agreement-and-factorial-structures-of-the-scared-questionnaire-in-an-italian-clinical-sample
#9
Simona Scaini, Anna Ogliari, Ludovica De Carolis, Laura Bellodi, Clelia Di Serio, Chiara Brombin
Background: A great part of the literature has confirmed the importance of both child and parents reports as source of factual information, especially for childhood emotional syndromes. In our study we aimed at: (i) calculating mother-child agreement and (ii) evaluating factorial structure of the Screen for Child Anxiety Related Emotional Disorders (SCARED) questionnaire in an Italian clinical sample. The novelty of this contribution is two-fold: first, from a clinical point of view, we investigated the parent-child agreement level and examined separately the factorial structures of both parent and child versions of the SCARED for the first time in an Italian clinical sample...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28285561/adverse-parenting-is-associated-with-blunted-salivary-cortisol-awakening-response-and-altered-expression-of-glucocorticoid-receptor-%C3%AE-and-%C3%AE-2-adrenergic-receptor-mrnas-in-leukocytes-in-japanese-medical-students
#10
Tomoko Kawai, Yuki Kuwano, Kiyoshi Masuda, Kinuyo Fujita, Hiroki Tanaka, Tatsuya Nishikawa, Kazuhito Rokutan, Kensei Nishida
Adverse parenting is associated with an increased risk for the development of mood and behavioral disorders. In this study, we assessed the perceived parental bonding of 232 medical students using the parental bonding instrument (PBI) and extracted 22 students who reported their parents' rearing attitudes as affectionless control (LOW; low care, high overprotection). Using the 28-item general health questionnaire, the Zung self-rating depression scale (Zung-SDS), the hospital anxiety and depression scale (HADS), and the Spielberger state-trait-anxiety-inventory (STAI), physical and mental state of the LOW students were compared with those of 30 students who reported their parental bonding as optimal (OPT; high care and low overprotection)...
March 12, 2017: Stress: the International Journal on the Biology of Stress
https://www.readbyqxmd.com/read/28279865/post-traumatic-stress-as-a-pathway-to-psychopathology-among-adolescents-at-high-risk-for-victimization
#11
Kelly D Cromer, Miguel T Villodas
OBJECTIVE: Victimization by violence elevates adolescents' risk for developing internalizing and externalizing psychopathology. Recent findings suggest that disruptions in developmental processes associated with post-traumatic stress (PTS) reactions may partially account for the relationship between victimization and the subsequent development of psychopathology during adolescence. The present study tested the temporal sequencing of these associations using multi-informant measurements in a large, diverse sample of adolescents at high-risk for victimization...
March 6, 2017: Child Abuse & Neglect
https://www.readbyqxmd.com/read/28278600/parenting-stress-among-caregivers-of-children-with-bipolar-spectrum-disorders
#12
Guillermo Perez Algorta, Heather A MacPherson, Eric A Youngstrom, Caroline C Belt, L Eugene Arnold, Thomas W Frazier, H Gerry Taylor, Boris Birmaher, Sarah McCue Horwitz, Robert L Findling, Mary A Fristad
Caregivers of psychiatrically impaired children experience considerable parenting stress. However, no research has evaluated parenting stress within the context of pediatric bipolar spectrum disorders (BPSD). Thus, the aim of this investigation was to identify predictors and moderators of stress among caregivers in the Longitudinal Assessment of Manic Symptoms study. Participants included 640 children and their caregivers in the Longitudinal Assessment of Manic Symptoms cohort. Children had a mean age of 9...
February 26, 2017: Journal of Clinical Child and Adolescent Psychology
https://www.readbyqxmd.com/read/28278599/mediators-of-treatment-outcomes-for-anxious-children-and-adolescents-the-role-of-somatic-symptoms
#13
Amy E Hale, Golda S Ginsburg, Grace Chan, Philip C Kendall, James T McCracken, Dara Sakolsky, Boris Birmaher, Scott N Compton, Anne Marie Albano, John T Walkup
Cognitive behavioral therapy (CBT) and selective serotonin reuptake inhibitors are effective treatments for pediatric anxiety disorders. However, the mechanisms of these treatments are unknown. Previous research indicated that somatic symptoms are reduced following treatment, but it is unclear if their reductions are merely a consequence of treatment gains. This study examined reductions in somatic symptoms as a potential mediator of the relationship between treatment and anxiety outcomes. Participants were 488 anxious youth ages 7-17 (M = 10...
February 26, 2017: Journal of Clinical Child and Adolescent Psychology
https://www.readbyqxmd.com/read/28270343/comprehensive-neuropsychological-evaluation-of-children-and-adolescents-with-sickle-cell-anemia-a-hospital-based-sample
#14
Samantha Nunes, Nayara Argollo, Marivania Mota, Camilo Vieira, Eduardo Pondé de Sena
BACKGROUND: Individuals with sickle cell anemia may suffer symptomatic or silent cerebral infarcts leading to neurocognitive complications. This study investigated the cognitive and intellectual performance of children and adolescents with sickle cell anemia. METHODS: The socioeconomic status, clinical aspects and behavioral profile of 15 young individuals with sickle cell anemia were evaluated. The Wechsler Intelligence Scale for Children, the Developmental Neuropsychological Assessment Test, and the Child Behavior Checklist were applied...
January 2017: Revista Brasileira de Hematologia e Hemoterapia
https://www.readbyqxmd.com/read/28263642/observer-youth-and-therapist-perspectives-on-the-alliance-in-cognitive-behavioral-treatment-for-youth-anxiety
#15
Bryce D McLeod, Michael A Southam-Gerow, Philip C Kendall
This study examined the score reliability and validity of observer- (Therapy Process Observational Coding System for Child Psychotherapy-Alliance scale [TPOCS-A]; Vanderbilt Therapeutic Alliance Scale Revised, Short Form [VTAS-R-SF]), therapist- (Therapeutic Alliance Scale for Children Therapist Version [TASC-T]), and youth-rated (Therapeutic Alliance Scale for Children Child Version [TASC-C]) alliance instruments. Youths (N = 50) aged 7-15 (Mage = 10.28 years, SD = 1.84; 88.0% Caucasian; 60.0% male) diagnosed with a principal anxiety disorder received manual-based cognitive-behavioral treatment...
March 6, 2017: Psychological Assessment
https://www.readbyqxmd.com/read/28259732/prenatal-exposure-to-anxiolytic-and-hypnotic-medication-in-relation-to-behavioral-problems-in-childhood-a-population-based-cohort-study
#16
Maja R Radojčić, Hanan El Marroun, Branislava Miljković, Bruno H C Stricker, Vincent W V Jaddoe, Frank C Verhulst, Tonya White, Henning Tiemeier
Benzodiazepines and benzodiazepine-related medications (BBRMs) are anxiolytics and hypnotics acting on γ-amino butyric acid (GABA)A receptors. BBRMs are assumed to have a low potential for major congenital malformations, but research on more subtle and protracted developing symptoms of these medications is lacking. Therefore, we prospectively investigated the association between BBRM use in pregnancy and long-term effects on child behavior in a large population-based cohort study. The study population consisted of 104 children prenatally exposed to BBRM, 527 children exposed to maternal prenatal anxiety or phobic anxiety symptoms (without exposure to BBRM), and 5609 control children...
March 1, 2017: Neurotoxicology and Teratology
https://www.readbyqxmd.com/read/28259062/the-association-between-parents-ratings-of-asd-symptoms-and-anxiety-in-a-sample-of-high-functioning-boys-and-adolescents-with-autism-spectrum-disorder
#17
Vicki Bitsika, Christopher F Sharpley
BACKGROUND: The relationship between symptoms of Autism Spectrum Disorder (ASD) and Generalised Anxiety Disorder (GAD) is complex and sometimes confounding. However, exploration of that relationship has significant potential to assist in treatment or avoidance of GAD by identifying ASD-related behaviours as 'targets' for intervention with anxious children as well as for preventative treatments that could be implemented into daily routines before children become anxious. To further understanding of this relationship, the association between parent-ratings of their sons' ASD symptoms and GAD symptoms was investigated in two samples of boys with high-functioning ASD...
March 1, 2017: Research in Developmental Disabilities
https://www.readbyqxmd.com/read/28254669/reactive-attachment-disinhibited-social-engagement-disorders-callous-unemotional-traits-and-comorbid-disorders
#18
Susan Dickerson Mayes, Susan L Calhoun, Daniel A Waschbusch, Rosanna P Breaux, Raman Baweja
BACKGROUND: DSM-5 Reactive Attachment Disorder (RAD) and Disinhibited Social Engagement Disorder (DSED) are rare, understudied, and controversial disorders. METHODS: Comorbidity in children diagnosed with RAD or DSED was compared with comorbidity in ADHD and autism to determine if RAD/DSED comorbidity differed from that for the two most common disorders in child psychiatric clinics. Samples included 4-17-year-olds, 20 with RAD and/or DSED, 933 with autism, and 895 with ADHD...
February 28, 2017: Research in Developmental Disabilities
https://www.readbyqxmd.com/read/28253735/antidepressant-efficacy-for-depression-in-children-and-adolescents-industry-and-nimh-funded-studies
#19
John T Walkup
Significant controversy surrounds the efficacy of the newer antidepressants for children and adolescents with depression. The controversy largely hinges on meta-analyses of studies that suggest that antidepressants are minimally effective, not effective, or equivalent to placebo. In this review, the author discusses several scientific and clinical complexities that are important to understand in reviewing the antidepressant literature: the strengths and weaknesses of meta-analyses; the scientific and regulatory context for the large number of antidepressant trials in the late 1990s and early 2000s; and the distinction between a negative trial, where the treatment does not demonstrate efficacy, and a failed trial, where methodological problems make it impossible to draw any conclusion about efficacy...
March 3, 2017: American Journal of Psychiatry
https://www.readbyqxmd.com/read/28251450/psychometric-properties-of-the-parent-version-of-the-revised-child-anxiety-and-depression-scale-in-a-clinical-sample-of-turkish-children-and-adolescents
#20
Vahdet Gormez, Ayse Kilincaslan, Chad Ebesutani, A Cahid Orengul, Ilyas Kaya, Veysi Ceri, Serhat Nasiroglu, Mekiya Filiz, Bruce F Chorpita
The Revised Child Anxiety and Depression Scale-Parent version (RCADS-P) is a self-report questionnaire that assesses dimensions of DSM-based anxiety and depressive disorders in children and adolescents. The present study examined the psychometric properties of the Turkish version in a clinical sample of 483 children and adolescents. The child and parent versions of the RCADS, parent versions of the Screen for Child Anxiety Related Emotional Disorders, the Strengths and Difficulties Questionnaire and Adolescent Symptom Inventory-Depression Scale were administered...
March 1, 2017: Child Psychiatry and Human Development
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