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Fecal lactoferrin

Mara de Moura Gondim Prata, A Havt, D T Bolick, R Pinkerton, Aam Lima, R L Guerrant
Fecal biomarkers have emerged as important tools to assess intestinal inflammation and enteropathy. The aim of this study was to investigate the correlations between the fecal markers, myeloperoxidase (MPO), lactoferrin (FL), calprotectin (FC) and lipocalin-2 (Lcn-2), and to compare differences by breastfeeding status as well as normalization by fecal protein or by fecal weight. Simultaneous, quantitative MPO, FL, FC and Lcn-2, levels were determined in frozen fecal specimens collected from 78 children (mean age 15...
2016: Journal of Translational Science
Anne-Claire Frin, Jérôme Filippi, Gilles Boschetti, Bernard Flourie, Jocelyne Drai, Patricia Ferrari, Xavier Hebuterne, Stéphane Nancey
BACKGROUND: Fecal markers might predict the response to anti-TNFα in ulcerative colitis (UC). AIMS: To compare the performance of fecal calprotectin (fCal), lactoferrin (fLact), M2-PK (fM2-PK), neopterin (fNeo), and zonulin (fZon) to predict the response to therapy in active UC patients. METHODS: Disease activity from 31 consecutive patients with an active UC, treated with infliximab (IFX) was assessed by the Mayo score at baseline and at week 14 and by the partial Mayo score at W52 and stool samples collected for fecal marker measurements at W0, W2, and W14...
September 13, 2016: Digestive and Liver Disease
Haihao Sun, Richard Vesely, Kerry Jo Lee, Agnes Klein, Mutsuhiro Ikima, Andrew E Mulberg
OBJECTIVE: There is a pressing need for drug development in pediatric Crohn's disease (CD). Our aim was to provide strategic approaches towards harmonization of current thinking about clinical outcome assessments (COA) and biomarkers to facilitate drug development in pediatric CD. METHODS: Scientists from the United States Food and Drug Administration, European Medicines Agency, Health Canada and the Pharmaceuticals and Medical Devices Agency of Japan had monthly teleconferences from 1/2014 through 5/2015...
June 2, 2016: Journal of Pediatric Gastroenterology and Nutrition
Michael P Sherman, Jan Sherman, Roxanne Arcinue, Victoria Niklas
UNLABELLED: The purpose of this study is to evaluate the effects of enteral lactoferrin on the fecal microbiome and contrast those influences with the neonatal intensive care unit (NICU) environment. We theorized that lactoferrin and the NICU habitat shape the fecal microbial composition of very preterm infants. Although functions attributed to lactoferrin include intestinal immune system development and emergence of a healthy gut microbiota, evidence is limited. Twenty-one very low birth weight (VLBW <1500 g) infants received twice-daily talactoferrin (TLf, a drug designation for recombinant human lactoferrin) or its excipient by gastric gavage from day 1-28 of life...
June 2016: Journal of Pediatrics
Kirsten Berding, Mei Wang, Marcia H Monaco, Lindsey S Alexander, Austin T Mudd, Maciej Chichlowski, Rosaline V Waworuntu, Brian M Berg, Michael J Miller, Ryan N Dilger, Sharon M Donovan
OBJECTIVE: This study tested the hypothesis that the addition of prebiotics and two functional milk ingredients to infant formula would maintain normal growth and gut development and modify microbiota composition and neurotransmitter gene expression in neonatal piglets. METHODS: Two-day-old male piglets (n = 24) were fed formula (CONT) or formula with polydextrose (PDX; 1.2 g/100 g diet), galactooligosaccharides (GOS; 3.5 g/100 g diet), bovine lactoferrin (Lf; 0...
March 23, 2016: Journal of Pediatric Gastroenterology and Nutrition
Roberta Caccaro, Imerio Angriman, Renata D'Incà
The role of fecal lactoferrin and calprotectin has been extensively studied in many areas of inflammatory bowel disease (IBD) patients' management. The post-operative setting in both Crohn's disease (CD) and ulcerative colitis (UC) patients has been less investigated although few promising results come from small, cross-sectional studies. Therefore, the current post-operative management still requires endoscopy 6-12 mo after intestinal resection for CD in order to exclude endoscopic recurrence and plan the therapeutic strategy...
March 27, 2016: World Journal of Gastrointestinal Surgery
Emily K Wright
BACKGROUND: The diagnosis and monitoring of inflammatory bowel disease (IBD) has traditionally relied on clinical assessment, serum markers of inflammation and endoscopic examination. Fecal biomarkers such as calprotectin (FC) and lactoferrin (FL) are predominantly derived from neutrophils, are easily detectable in the feces and are now established as valuable markers of intestinal inflammation. In recent years, a 'treat to target' concept has emerged for the management of IBD. Adequate control of inflammation in IBD at a biochemical level is quickly becoming an important target in IBD management...
2016: Digestive Diseases
Jason Orlando Dimitri Musci, Jack Stephen Cornish, Jan Däbritz
Patients with diagnosed inflammatory bowel disease (IBD) will commonly experience a clinical relapse in spite of a prolonged therapy-induced period of clinical remission. The current methods of assessing subclinical levels of low-grade inflammation which predispose patients to relapse are not optimal when considering both cost and patient comfort. Over the past few decades, much investigation has discovered that proteins such as calprotectin that are released from inflammatory cells are capable of indicating disease activity...
June 2016: Journal of Gastroenterology
Rafail I Kushak, Timothy M Buie, Katherine F Murray, David S Newburg, Ceng Chen, Eirini Nestoridi, Harland S Winter
OBJECTIVE: Alterations in intestinal function, often characterized as a "leaky gut," have been attributed to children who are on the autism spectrum. Disaccharidase activity, intestinal inflammation, and permeability were analyzed in 61 children with autism and 50 nonautistic individuals with gastrointestinal symptoms. METHODS: All patients had duodenal biopsies assayed for lactase, sucrase, maltase, and palatinase activity. Intestinal permeability was evaluated by rhamnose/lactulose test and measured by high-performance liquid chromatography-mass spectrometry...
May 2016: Journal of Pediatric Gastroenterology and Nutrition
Jost Langhorst, James Boone, Romy Lauche, Andreas Rueffer, Gustav Dobos
OBJECTIVES: We evaluated the performance of blood and faecal biomarkers for differentiating between endoscopic inflammation and mucosal healing, and clinically active disease and sustained clinical remission, and determined the predictive value for a flare in patients with ulcerative colitis [UC]. METHODS: Clinical Activity Index [CAI], faecal lactoferrin [FLA], calprotectin [CAL], PMN-elastase [PMN-e], C-reactive protein [CRP], white blood cells [WBC], Endoscopic Index [EI], and UC-Disease Activity Index [DAI] were determined repeatedly during 12 months and at acute flares...
July 2016: Journal of Crohn's & Colitis
William Sandborn, Christopher Gasink, Marion Blank, Yinghua Lang, Jewel Johanns, Long-Long Gao, Bruce Sands, Stephen Hanauer, Brian Feagan, Stephan Targan, Subrata Ghosh, Wim de Villiers, Jean-Frédéric Colombel, Scott Lee, Pierre Desreumaux, Edward Loftus, Severine Vermeire, Paul Rutgeerts
BACKGROUND: Interleukins 12&23 are implicated in the pathophysiology of Crohn's disease (CD). These pro-inflammatory cytokines are blocked by ustekinumab (UST). In a previous Phase 2b study (CERTIFI), UST IV induction followed by SC maintenance was shown effective in moderate-severe CD refractory to anti-TNF therapy. This Phase 3 study examined the efficacy and safety of IV UST induction in these patients. METHODS: Patients with moderate-severely active CD (CDAI 220-450) who previously failed or were intolerant to at least 1 TNF-antagonist were randomized (1:1:1) at Week (Wk) 0 to a single dose of IV placebo (PBO), UST 130 mg, or weight-based tiered UST dosing approximating 6 mg/kg (260mg [weight ≤55 kg], 390mg [weight >55 kg and ≤85 kg], 520mg [weight >85 kg])...
March 2016: Inflammatory Bowel Diseases
Emily K Wright, Michael A Kamm, Peter De Cruz, Amy L Hamilton, Kathryn J Ritchie, Jacqueline I Keenan, Steven Leach, Laura Burgess, Alan Aitchison, Alexandra Gorelik, Danny Liew, Andrew S Day, Richard B Gearry
BACKGROUND: Fecal biomarkers are used increasingly to monitor Crohn's disease (CD). However, the relative accuracy of different markers in identifying inflammation has been poorly evaluated. We evaluated fecal calprotectin (FC), lactoferrin (FL), and S100A12 (FS) using endoscopic validation in a prospective study of the progression of CD after intestinal resection. METHODS: Data were collected from 135 participants in a prospective, randomized, controlled trial aimed at preventing postoperative CD recurrence...
May 2016: Inflammatory Bowel Diseases
Barbara Iwańczak, Franciszek Iwańczak
In the recent decades the rapid development of the studies on new methods used in diagnosis, differential diagnosis, and monitoring the treatment of inflammatory bowel diseases has been observed. To the diagnostics of gastrointestinal disorders new methods such as endoscopic capsule and imaging methods including magnetic resonance have been introduced. Markers of inflammation detected in stool play significant role in the diagnostics. To the best known belong calprotectine and lactoferrin, which are produced by neutral granulocytes...
December 2015: Polski Merkuriusz Lekarski: Organ Polskiego Towarzystwa Lekarskiego
Victoria Emma Anikst, Rajiv Lochan Gaur, Lee Frederick Schroeder, Niaz Banaei
Clostridium difficile infection is often overdiagnosed in patients with mild diarrhea. We evaluated 4 biomarkers as surrogates for clinically significant diarrhea (≥ 3 episodes in 24 hours) in 59 PCR-positive patients with and 59 PCR-positive patients without clinically significant diarrhea. Organism burden (median tcdB cycle threshold value, 26.9 versus 27.1, P=0.25) and toxin A and B concentrations (toxin A, median, 0 versus 0 ng/mL, P=0.42; toxin B, median, 0 versus 0 ng/mL, P=0.25) were not significantly different between patients with and without clinically significant diarrhea...
April 2016: Diagnostic Microbiology and Infectious Disease
Dorota Mańkowska-Wierzbicka, Ewelina Swora-Cwynar, Barbara Poniedziałek, Zygmunt Adamski, Agnieszka Dobrowolska, Jacek Karczewski
INTRODUCTION: This study aimed to compare the accuracy of selected laboratory markers in assessing disease activity in patients with ulcerative colitis (UC). The analysis included serum IL-2, IL-4, IL-6, IL-10, IL-17, TNF-, IFN-, hsCRP, peripheral regulatory T cells, as well as fecal calprotectin and lactoferrin. PATIENTS AND METHODS: A group of 45 adults with UC was enrolled in the study. Disease activity was assessed using the Mayo endoscopic index, while for clinical activity scoring, the Clinical Activity Index (CAI) was used...
April 2015: European Cytokine Network
Nancy A Rodriguez, Maximo Vento, Erika C Claud, Chihsiung E Wang, Michael S Caplan
BACKGROUND: Extremely premature (birth weight < 1250 g) infants are at high risk for acquiring late-onset sepsis and necrotizing enterocolitis, which are associated with significant mortality and morbidity. Own mother's milk contains protective (immune and trophic) biofactors which provide antimicrobial, anti-inflammatory, antioxidant, and immunomodulatory functions, enhance intestinal microbiota, and promote intestinal maturation. Many of these biofactors are most highly concentrated in the milk expressed by mothers of extremely premature infants...
2015: Trials
Anna Borkowska, Anna Liberek, Grażyna Łuczak, Agnieszka Jankowska, Katarzyna Plata-Nazar, Maria Korzon, Barbara Kamińska
The aim of this study was to analyze the usefulness of fecal lactoferrin in the diagnosis and monitoring of inflammatory bowel disease (IBD) in children. The study included 52 children with IBD (24 with Crohn's disease and 28 with ulcerative colitis) aged between 0.92 and 18 years, and 41 IBD-free controls of similar age. Fecal concentration of lactoferrin was determined with a quantitative immunoenzymatic test. Fecal concentration of lactoferrin in children with IBD was significantly higher than in the controls...
2015: Acta Biochimica Polonica
Cong Dai, Min Jiang, Ming-Jun Sun
No abstract text is available yet for this article.
August 2015: American Journal of Gastroenterology
Anna Barker, Megan Duster, Susan Valentine, Laurie Archbald-Pannone, Richard Guerrant, Nasia Safdar
BACKGROUND: Clostridium difficile is a pathogen of rapidly increasing public health importance. An estimated quarter of a million Clostridium difficile infections (CDI) occur in the United States annually, at a resultant cost of 14,000 deaths and 1 billion dollars. Clostridium difficile related deaths have risen 400% over the last decade, and current standard antibiotic treatments are only 75 to 85% successful. Besides increasing the risk of antibiotic resistance and side effects, these treatments are very expensive...
July 22, 2015: Contemporary Clinical Trials
Katarzyna Klimczak, Liliana Lykowska-Szuber, Piotr Eder, Iwona Krela-Kazmierczak, Kamila Stawczyk-Eder, Aleksandra Szymczak, Michal Michalak, Adam Studniarek, Krzysztof Linke
BACKGROUND: Diagnosis and monitoring of Crohn's disease (CD) is difficult and time-consuming. In recent years, diagnostic usefulness of fecal calprotectin has been proven. However, data on the utility of other fecal markers are scarce. AIMS: To evaluate the usefulness of fecal lactoferrin (FL) in the assessment of CD activity. METHODS: The group consisted of 101 CD patients (median age: 30 years, IQR: 24-37). FL was measured in a single stool sample by using the immunoenzymatic methods...
October 2015: European Journal of Internal Medicine
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