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Fecal calprotectin

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https://www.readbyqxmd.com/read/29135821/compliance-with-fecal-calprotectin-testing-in-pediatric-inflammatory-bowel-disease-patients
#1
Karen Queliza, Michael K Wang, Richard Kellermayer
Fecal calprotectin (FC) is a highly sensitive biomarker for inflammatory bowel diseases (IBDs). Utilization of this assay has been steadily increasing. However, adherence levels for FC have yet to be examined in the pediatric IBD setting. We analyzed 100 consecutive patients diagnosed with IBD between 2014 and 2015 at Texas Children's Hospital. Fifty-six percent of patients were male and median age at diagnosis was 13.7 years. Following diagnosis of IBD, 84 patients had a minimum of one FC requested, and 95...
November 10, 2017: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/29132736/clinical-effects-of-probiotics-in-cystic-fibrosis-patients-a-systematic-review
#2
Stephanie Van Biervliet, Dimitri Declercq, Shawn Somerset
Cystic fibrosis (CF) is characterised by a build-up of thick, intransient mucus linings of the digestive and respiratory mucosa, which disrupts digestive system functioning and microbiota composition. In view of the potential for probiotics to enhance microbiota composition in other contexts, this study investigated the current evidence for probiotics as an adjunct to usual therapy for CF. Electronic clinical databases were interrogated for human randomised, controlled, intervention trials (1985-2015) testing the effects of probiotics on clinical endpoints in CF were reviewed...
April 2017: Clinical Nutrition ESPEN
https://www.readbyqxmd.com/read/29121442/enteric-infections-in-young-children-are-associated-with-environmental-enteropathy-and-impaired-growth
#3
Christine Marie George, Vanessa Burrowes, Jamie Perin, Lauren Oldja, Shwapon Biswas, David Sack, Shahnawaz Ahmed, Rashidul Haque, Nurul Amin Bhuiyan, Tahmina Parvin, Sazzadul Islam Bhuyian, Mahmuda Akter, Shan Li, Gayathri Natarajan, Mohammad Shahnaij, Abu G Faruque, O Colin Stine
OBJECTIVE: To investigate the relationship between fecal contamination in child play spaces, enteric infections, environmental enteropathy (EE), and impaired growth among young children. METHODS: Prospective cohort study of 203 children 6-30 months of age in rural Bangladesh. Stool samples were analyzed by quantitative PCR for Shigella, Enterotoxigenic Escherichia coli (ETEC), Campylobacter jejuni, Giardia spp, and Cryptosporidium spp. Four fecal markers of intestinal inflammation were also measured: alpha-1-antitrypsin, myeloperoxidase, neopterin, and calprotectin...
November 9, 2017: Tropical Medicine & International Health: TM & IH
https://www.readbyqxmd.com/read/29118554/risk-factors-for-postoperative-recurrence-of-crohn-s-disease-with-emphasis-on-surgical-predictors
#4
REVIEW
Antonios Gklavas, Dionysios Dellaportas, Ioannis Papaconstantinou
Intestinal resection for Crohn's disease is not curative and postoperative recurrence rates remain high. Early detection of indices associated with recurrence and risk stratification are fundamental for the postoperative management of patients. Early endoscopy at 6-12 months is the "gold standard" procedure, whereas other modalities such as fecal calprotectin and imaging techniques can contribute to the diagnosis of recurrence. The purpose of this review is to summarize current data regarding risk factors correlated with postoperative relapse...
2017: Annals of Gastroenterology: Quarterly Publication of the Hellenic Society of Gastroenterology
https://www.readbyqxmd.com/read/29115397/detection-of-calprotectin-in-inflammatory-bowel-disease-fecal-and-serum-levels-and-immunohistochemical-localization
#5
Shuhei Fukunaga, Kotaro Kuwaki, Keiichi Mitsuyama, Hidetoshi Takedatsu, Shinichiro Yoshioka, Hiroshi Yamasaki, Ryosuke Yamauchi, Atsushi Mori, Tatsuyuki Kakuma, Osamu Tsuruta, Takuji Torimura
The aim of the present study was to quantify calprotectin levels using an enzyme-linked immunosorbent assay (ELISA) and a point-of-care test (POCT) in patients with inflammatory bowel disease. Overall, 113 patients with ulcerative colitis (UC; 51 men and 62 women) and 42 patients with Crohn's disease (CD; 29 men and 13 women), who were scheduled to undergo a colonoscopy, were prospectively enrolled and scored endoscopically and clinically. An additional 96 healthy, age-matched subjects served as the normal controls...
November 7, 2017: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29112087/fecal-amino-acid-analysis-can-discriminate-de-novo-treatment-na%C3%A3-ve-pediatric-inflammatory-bowel-disease-from-controls
#6
Sofie Bosch, Eduard A Struys, Nora van Gaal, Abdellatif Bakkali, Erwin W Jansen, Kay Diederen, Marc A Benninga, Chris J Mulder, Nanne K H de Boer, Tim G J de Meij
OBJECTIVES: Endoscopy remains mandatory in the diagnostic work-up of inflammatory bowel disease (IBD), but is a costly and invasive procedure. Identification of novel, non-invasive, diagnostic biomarkers remains a priority. The aim of this study was to explore the potential of fecal amino acid composition as diagnostic biomarker for pediatric IBD. METHODS: In this case-control study, treatment-naïve, de novo pediatric IBD patients from two tertiary centers were included...
November 3, 2017: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/29097934/correlation-of-18f-fdg-pet-mre-metrics-with-inflammatory-biomarkers-in-patients-with-crohn-s-disease-a-pilot-study
#7
Liran Domachevsky, Haim Leibovitzh, Irit Avni-Biron, Lev Lichtenstein, Natalia Goldberg, Meital Nidam, David Groshar, Hanna Bernstine, Ofer Ben-Bassat
Background: To investigate the association between 18F-FDG (Fluorodeoxyglucose) PET (positron emission tomography)/MRE (magnetic resonance enterography) metrics with the inflammatory biomarkers fecal calprotectin and C-reactive protein (CRP) in patients with Crohn's disease (CD). Methods: This prospective pilot study was institutional review board (IRB) approved with informed consent obtained. Consecutive CD patients were referred to 18F-FDG PET/MRE. Patients in whom colonoscopy was performed and CRP and fecal calprotectin levels were measured were included...
2017: Contrast Media & Molecular Imaging
https://www.readbyqxmd.com/read/29084074/clinical-and-symptom-scores-are-significantly-correlated-with-fecal-microbiota-features-in-patients-with-symptomatic-uncomplicated-diverticular-disease-a-pilot-study
#8
Charlotte L Kvasnovsky, Lex E X Leong, Jocelyn M Choo, Guy C J Abell, Savvas Papagrigoriadis, Kenneth D Bruce, Geraint B Rogers
BACKGROUND: There is growing consensus that symptomatic uncomplicated diverticular disease is a chronic inflammatory condition, and that alterations in the fecal microbiota may contribute to its pathogenesis. OBJECTIVE: The aim of this study was to relate the fecal microbiota composition in symptomatic uncomplicated diverticular disease to measures of inflammation, symptoms, and history of previous acute diverticulitis. PARTICIPANTS AND METHODS: Fecal microbiota composition in 28 individuals with symptomatic uncomplicated diverticular disease was characterized by 16S RNA gene amplicon sequencing...
October 27, 2017: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29065905/severe-intestinal-dysbiosis-is-prevalent-in-primary-sj%C3%A3-gren-s-syndrome-and-is-associated-with-systemic-disease-activity
#9
Thomas Mandl, Jan Marsal, Peter Olsson, Bodil Ohlsson, Kristofer Andréasson
BACKGROUND: Altered microbial composition of the intestine, commonly referred to as dysbiosis, has been associated with several autoimmune diseases including primary Sjögren's syndrome (pSS). The aims of the current study were to study the intestinal microbial balance in pSS and to identify clinical features associated with dysbiosis. METHODS: Forty-two consecutive pSS patients and 35 age-matched and sex-matched control subjects were included in the study in an open clinic setting...
October 24, 2017: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/29065739/fecal-calprotectin-in-management-of-clostridium-difficile-infection-a-longitudinal-study
#10
Antonella Gallo, Carla Vallone, Ludovico Sabatelli, Giulio Ventura, Marcello Covino, Giovanni Cammarota, Antonio Gasbarrini, Raffaele Landolfi, Massimo Montalto
BACKGROUND: Clostridium difficile infection (CDI) is characterized by a relevant intestinal neutrophil infiltrate. So far, role of fecal calprotectin in CDI, has been investigated only in few studies, mainly focused on diagnosis of the disease. AIM: By a longitudinal design, we assess fecal calprotectin concentrations (FCCs) in subjects with CDI, evaluating the correlation between fecal marker and response to therapy. METHODS: Clinical (diarrhea scoring) and laboratory (FCCs and leucocytes count) evaluation was performed in 56 subjects with CDI at time of diagnosis (T0) and after a week from starting of therapy (T1)...
October 24, 2017: Scandinavian Journal of Gastroenterology
https://www.readbyqxmd.com/read/29061121/fecal-calprotectin-predicts-complete-mucosal-healing-and-better-correlates-with-the-ulcerative-colitis%C3%A2-endoscopic-index-of-severity-than-with-the-mayo-endoscopic-subscore-in-patients-with-ulcerative-colitis
#11
Sun-Ho Lee, Min-Ju Kim, Kiju Chang, Eun Mi Song, Sung Wook Hwang, Sang Hyoung Park, Dong-Hoon Yang, Kyung-Jo Kim, Jeong-Sik Byeon, Seung-Jae Myung, Suk-Kyun Yang, Byong Duk Ye
BACKGROUND: We aimed to evaluate the role of fecal calprotectin (FC) as a noninvasive marker for the disease activity of ulcerative colitis (UC) in a Korean cohort. METHODS: A total of 181 fecal samples were collected from 181 consecutive UC patients between April 2015 and September 2016. FC levels were measured using the Quantum Blue(®) Calprotectin rapid test. The laboratory test results, partial Mayo Score (pMS), and colonoscopic imaging findings at FC level measurement were retrospectively reviewed...
October 23, 2017: BMC Gastroenterology
https://www.readbyqxmd.com/read/29061007/-significance-of-serum-calprotectin-in-assessing-inflammatory-bowel-disease-activity
#12
J Y Mao, L Li, Z Pang
Objective: To investigate the application value of serum calprotectin in assessing the activity of IBD Methods: Eighty-five Crohn's disease(CD) and eighty-five Ulcerative colitis(UC) patients at Suzhou Municipal Hospital(North Branch) from August 2015 to January 2017 were enrolled in this study, and eighty-five healthy subjects were selected as controls. Serum level of calprotectin was determined by ELISA. Correlation of serum calprotectin with clinical features of IBD was analyzed. The diagnostic efficacy for CD and UC were assessed by ROC curve...
October 17, 2017: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/29032392/exercise-and-gastrointestinal-symptoms-running-induced-changes-in-intestinal-permeability-and-markers-of-gastrointestinal-function-in-asymptomatic-and-symptomatic-runners
#13
Elisa Karhu, Richard A Forsgård, Lauri Alanko, Henrik Alfthan, Pirkko Pussinen, Esa Hämäläinen, Riitta Korpela
PURPOSE: Athletes frequently experience gastrointestinal (GI) symptoms during training and competition. Although the prevalence of exercise-induced GI symptoms is high, the mechanisms leading to GI distress during exercise are not fully understood. The aim of this study was to identify running-induced changes in intestinal permeability and markers of GI function and investigate their association with gastrointestinal symptoms. METHODS: We recruited 17 active runners who we allocated as either asymptomatic or symptomatic based on their history of experiencing GI symptoms during running...
October 14, 2017: European Journal of Applied Physiology
https://www.readbyqxmd.com/read/29024038/baseline-lab-parameters-predicting-clinical-outcome-in-melanoma-patients-treated-with-ipilimumab-a-single-center-analysis
#14
Thilo Gambichler, Victoria Brown, Ann-Kathrin Steuke, Lutz Schmitz, Eggert Stockfleth, Laura Susok
BACKGROUND: Overall response rates (ORR) for ipilimumab in advanced melanoma are only about 10%. Hence, it is important to explore biomarkers predicting ipilimumab responders. OBJECTIVE: We aimed to explore biomarkers in order to predict therapy outcome in melanoma patients who have undergone standard ipilimumab therapy in a real-world setting. METHODS: Databases of cutaneous melanoma patients (n = 52) who had received ipilimumab were reviewed and data collected on patient characteristics and diverse lab parameters...
October 10, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29018973/clinical-significance-of-fecal-calprotectin-for-the-early-diagnosis-of-abdominal-type-of-henoch-schonlein-purpura-in-children
#15
Xu Teng, Cuiyun Gao, Mei Sun, Jie Wu
The objective of this study is to explore the value of fecal calprotectin (FC) for early screening of the abdominal type of Henoch-Schonlein purpura (AHSP) in children. The study cohort included 40 children with AHSP treated at Shengjing Hospital of China Medical University from November 2014 to November 2015, and 40 children hospitalized in the Division of Pediatric Orthopedics in the corresponding period were selected as a control group. Fresh fecal samples were collected in the acute phase of the first visit (FC1), 3 days after treatment (FC2), and 7 days after treatment (FC3) from the AHSP group and the control group...
October 10, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/28969890/lactobacillus-reuteri-for-infants-with-colic-a-double-blind-placebo-controlled-randomized-clinical-trial
#16
Nicole Y Fatheree, Yuying Liu, Christopher M Taylor, Thomas K Hoang, Chunyan Cai, Mohammad H Rahbar, Manouchehr Hessabi, Michael Ferris, Valarie McMurtry, Christine Wong, Ta Vu, Theresa Dancsak, Ting Wang, Wallace Gleason, Vinay Bandla, Fernando Navarro, Dat Q Tran, J Marc Rhoads
OBJECTIVE: To assess the safety of probiotic Lactobacillus reuteri strain Deutsche Sammlung von Mikroorganismen (DSM) 17938 with daily administration to healthy infants with colic and to determine the effect of L reuteri strain DSM 17938 on crying, fussing, inflammatory, immune, and microbiome variables. STUDY DESIGN: We performed a controlled, double-blinded, phase 1 safety and tolerability trial in healthy breast-fed infants with colic, aged 3 weeks to 3 months, randomly assigned to L reuteri strain DSM 17938 (5 × 10(8) colony-forming units daily) or placebo for 42 days and followed for 134 days...
September 29, 2017: Journal of Pediatrics
https://www.readbyqxmd.com/read/28969887/crying-time-and-ror%C3%AE-foxp3-expression-in-lactobacillus-reuteri-dsm17938-treated-infants-with-colic-a-randomized-trial
#17
Francesco Savino, Maria Garro, Paola Montanari, Ilaria Galliano, Massimiliano Bergallo
OBJECTIVES: To evaluate crying time, retinoid-related orphan receptor-γ (RORγ) and forkhead box P3 (FOXP3) messenger RNA levels (transcription factors that can modulate T cell responses to gut microbes), and to investigate gut microbiota and fecal calprotectin in infants treated with Lactobacillus reuteri for infantile colic. STUDY DESIGN: A double-blind, placebo-controlled randomized trial was conducted in primary care in Torino from August 1, 2015 to September 30, 2016...
September 29, 2017: Journal of Pediatrics
https://www.readbyqxmd.com/read/28961792/simultaneous-measurements-of-fecal-calprotectin-and-the-fecal-immunochemical-test-in-quiescent-ulcerative-colitis-patients-can-stratify-risk-of-relapse
#18
Asuka Nakarai, Sakiko Hiraoka, Sakuma Takahashi, Tomoki Inaba, Reiji Higashi, Motowo Mizuno, Shiho Takashima, Toshihiro Inokuchi, Yuusaku Sugihara, Masahiro Takahara, Keita Harada, Jun Kato, Hiroyuki Okada
Background: Both fecal calprotectin (Fcal) and the fecal immunochemical test (FIT) are useful to predict clinical relapse of ulcerative colitis (UC). However, the difference between Fcal and FIT in the ability to predict relapse has scarcely been reported. Whether the combined use of these two fecal markers increases the predictability is also unknown. Methods: UC patients in clinical remission who underwent colonoscopy were enrolled prospectively, and the Fcal and FIT values were examined at enrollment...
August 31, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28949435/clinical-endoscopical-and-histological-correlation-and-measures-of-association-in-ulcerative-colitis
#19
Daniela Fluxá, Daniela Simian, Lilian Flores, Patricio Ibáñez, Jaime Lubascher, Carolina Figueroa, Rodrigo Quera, Udo Kronberg, Gonzalo Pizarro, Magdalena Castro, Antonio Piottante, María Teresa Vial
AIM: To determine the correlation between clinical, fecal, endoscopic and histologic activity in patients with ulcerative colitis. METHODS: A correlational analytic cross-sectional study was performed in patients with ulcerative colitis who underwent colonoscopy between February and December 2016. Clinical, endoscopic, fecal and histologic activities were determined using the Partial Mayo Subscore, Endoscopic Subscore and Mayo Modified Endoscopic Subscore, Fecal Calprotectin and Geboes Score and the presence of basal plasmacytosis, respectively...
September 26, 2017: Journal of Digestive Diseases
https://www.readbyqxmd.com/read/28948412/rapid-fecal-calprotectin-test-and-symptom-index-in-monitoring-the-disease-activity-in-colonic-inflammatory-bowel-disease
#20
Anna-Maija Puolanne, Kaija-Leena Kolho, Henrik Alfthan, Ari Ristimäki, Harri Mustonen, Martti Färkkilä
BACKGROUND: Fecal calprotectin is a reliable surrogate marker for inflammatory activity in inflammatory bowel disease (IBD). AIMS: For the noninvasive monitoring of the activity of colonic inflammation, we validated a symptom index suitable for ulcerative colitis and colonic Crohn's disease. By combining the symptom index with a rapid semi-quantitative calprotectin test, we constructed a new activity index based on the highest AUCs, using histological remission as a reference...
November 2017: Digestive Diseases and Sciences
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