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Fecal calprotectin

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https://www.readbyqxmd.com/read/28634577/commentary-impact-of-fecal-calprotectin-measurement-on-decision-making-in-children-with-inflammatory-bowel-disease
#1
COMMENT
Andrew S Day, Mustafa Adamji
No abstract text is available yet for this article.
2017: Frontiers in Pediatrics
https://www.readbyqxmd.com/read/28629912/calprotectin-and-the-magnitude-of-antibodies-to-infliximab-in-clinically-stable-ulcerative-colitis-patients-are-more-relevant-than-infliximab-trough-levels-and-pharmacokinetics-for-therapeutic-escalation
#2
Fernando Magro, Joana Afonso, Susana Lopes, Rosa Coelho, Raquel Gonçalves, Paulo Caldeira, Paula Lago, Helena Tavares de Sousa, Jaime Ramos, Ana Rita Gonçalves, Paula Ministro, Isadora Rosa, Ana Isabel Vieira, Patrícia Andrade, João-Bruno Soares, Diana Carvalho, Paula Sousa, Tânia Meira, Joanne Lopes, Joana Moleiro, Cláudia Camila Dias, Amílcar Falcão, Karel Geboes, Fatima Carneiro
Although infliximab (IFX) is an efficient therapy for ulcerative colitis (UC) patients, a considerably high rate of therapeutic failures still occurs. This study aimed at a better understanding of IFX pharmacokinetics and pharmacodynamics among clinically-asymptomatic UC patients. This was a multicentric and prospective study involving 65 UC patients in the maintenance phase of IFX therapy. There were no significant differences between patients with positive and negative clinical, endoscopic and histological outcomes concerning their IFX trough levels (TLs), area under the IFX concentration vs...
June 7, 2017: EBioMedicine
https://www.readbyqxmd.com/read/28627817/turbidimetric-determination-of-fecal-calprotectin-using-two-table-top-chemistry-analyzers-mindray-bs-200e-and-cobas%C3%A2-c111
#3
Aleksandra Mandic-Havelka, Tom Nilsen, Kathrin Sunde, Maria Norell, Lars O Hansson, Anders Larsson
BACKGROUND: Fecal calprotectin assays are widely used in diagnosis and monitoring of inflammatory bowel disease (IBD) in patients with suspected IBD. The most frequently used technique is ELISA and microtiter plates. Turbidimetric assays for analysis of fecal calprotectin can significantly reduce turnaround time. Many laboratories may be reluctant to run fecal samples on their large chemistry analyzers. The aim of this study was to evaluate fecal calprotectin particle enhanced turbidimetric immunoassay (PETIA) on smaller chemistry analyzers that could be dedicated for fecal samples...
May 1, 2017: Clinical Laboratory
https://www.readbyqxmd.com/read/28617758/individualized-infliximab-treatment-guided-by-patient-managed-ehealth-in-children-and-adolescents-with-inflammatory-bowel-disease
#4
Katrine Carlsen, Gunnar Houen, Christian Jakobsen, Thomas Kallemose, Anders Paerregaard, Lene B Riis, Pia Munkholm, Vibeke Wewer
BACKGROUND: To individualize timing of infliximab (IFX) treatment in children and adolescents with inflammatory bowel disease (IBD) using a patient-managed eHealth program. METHODS: Patients with IBD, 10 to 17 years old, treated with IFX were prospectively included. Starting 4 weeks after their last infusion, patients reported a weekly symptom score and provided a stool sample for fecal calprotectin analysis. Based on symptom scores and fecal calprotectin results, the eHealth program calculated a total inflammation burden score that determined the timing of the next IFX infusion (4-12 wk after the previous infusion)...
June 14, 2017: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/28606846/agreement-between-home-based-measurement-of-stool-calprotectin-and-elisa-results-for-monitoring-inflammatory-bowel-disease-activity
#5
Anke Heida, Mariska Knol, Anneke Muller Kobold, Josette Bootsman, Gerard Dijkstra, Patrick F van Rheenen
BACKGROUND AND AIMS: An increasing number of physicians use repeated measurements of stool calprotectin to monitor intestinal inflammation in patients with inflammatory bowel diseases (IBD). A lateral flow-based rapid test allows patients to measure their own stool calprotectin values at home. The test comes with a software application (IBDoc) that turns a smartphone camera into a results reader. We compared results from this method with those from the hospital-based reader (Quantum Blue) and ELISA analysis...
June 9, 2017: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28601328/correlation-between-fecal-calprotectin-and-inflammation-in-the-surgical-specimen-of-crohn-s-disease
#6
Salvador Pous-Serrano, Matteo Frasson, Elena Cerrillo, Belén Beltrán, Marisa Iborra, David Hervás, Eduardo García-Granero, Pilar Nos
BACKGROUND: An accurate assessment of the inflammatory activity is crucial to establish the most appropriate treatment in Crohn's disease (CD). The present study aimed to evaluate the utility of preoperative fecal calprotectin (FC) measurement in small bowel CD and its relationship with inflammatory activity in surgical pathology specimens. METHODS: This was a prospective observational study including all the patients with small bowel CD operated on at our center between March 2011 and September 2013...
June 1, 2017: Journal of Surgical Research
https://www.readbyqxmd.com/read/28590341/fecal-calprotectin-levels-predict-histological-healing-in-ulcerative-colitis
#7
Anish Patel, Hinaben Panchal, Marla C Dubinsky
BACKGROUND: Mucosal healing as measured by endoscopic activity is the therapeutic target for ulcerative colitis (UC) and associated with improved outcomes. We investigated the clinical utility of fecal calprotectin (FC) levels to predict depth of remission, including histological remission in patients with UC. METHODS: We performed a retrospective chart review of patients with UC who underwent a full colonoscopy and FC measured within 6 weeks before colonoscopy at a tertiary inflammatory bowel disease center...
June 5, 2017: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/28587751/usability-of-a-home-based-test-for-the-measurement-of-fecal-calprotectin-in-asymptomatic-ibd-patients
#8
Caroline Bello, Arne Roseth, Jordi Guardiola, Catherine Reenaers, Alexandra Ruiz-Cerulla, Catherine Van Kemseke, Claudia Arajol, Christian Reinhard, Laurence Seidel, Edouard Louis
The aim of our work was to test the usability of fecal calprotectin (FC) home-based test in inflammatory bowel disease (IBD) patients. METHODS: IBD patients were prospectively recruited. They had to measure FC with a dedicated tool and smartphone application, 5 times at two weeks intervals over an 8 weeks period. They had to fill in a usability questionnaire at the first and the last FC measurement. A System Usability Scale (SUS: 0-100) and the Global Score of Usability (GSU: 0-85) were calculated...
May 19, 2017: Digestive and Liver Disease
https://www.readbyqxmd.com/read/28566121/danish-national-guideline-diagnosis-and-treatment-of-irritable-bowel-syndrome
#9
Anne Lund Krarup, Anne Line Østergaard Engsbro, Janne Fassov, Lotte Fynne, Anders Bak Christensen, Peter Bytzer
National Danish guidelines for the diagnosis and treatment of irritable bowel syndrome (IBS) in adult patients in secondary and tertiary care have been approved by the Danish Society for Gastroenterology and Hepatology. IBS can be a positive diagnosis in patients fulfilling the Rome III criteria for IBS with no alarm signals, a normal physical examination and a normal CRP and hemoglobin. In patients < 40 years with IBS and diarrhea, a normal fecal calprotectin excludes inflammatory bowel disease with a high probability...
June 2017: Danish Medical Journal
https://www.readbyqxmd.com/read/28550491/influence-of-diet-on-the-course-of-inflammatory-bowel-disease
#10
Laura Tasson, Cristina Canova, Maria Grazia Vettorato, Edoardo Savarino, Renzo Zanotti
BACKGROUND: While the importance of diet in the pathogenesis of inflammatory bowel disease (IBD) is generally recognized, influence of food on the course of IBD is little understood. AIM: The purpose of this study was to assess the association between food intake and course of disease in patients with IBD. METHODS: We performed a cross-sectional study on 103 adult patients (50 with active disease and 53 in remission, divided by their calprotectin level), who completed a food frequency questionnaire on their intake of several foods over 1 year...
May 26, 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/28539226/fecal-calprotectin-as-an-alternative-to-ulcerative-colitis-endoscopic-index-of-severity-to-predict-the-response-to-corticosteroids-of-acute-severe-ulcerative-colitis-a-prospective-observational-study
#11
Tingbin Xie, Chenyan Zhao, Chao Ding, Tenghui Zhang, Xujie Dai, Tengfei Lv, Yi Li, Zhen Guo, Jianfeng Gong, Weiming Zhu
BACKGROUND: Fecal calprotectin (FC) might be an alternative to ulcerative colitis endoscopic index of severity (UCEIS) to predict the response to corticosteroids (CS) in acute severe colitis (ASC). METHODS: One hundred and seventeen ASC patients were prospectively enrolled. Demographic, clinical, laboratory and sigmoidoscopic data were documented. Multivariate and ROC analyses were performed to identify risk factors for non-response to CS, and the predictive accuracy of possible predictors was assessed...
May 3, 2017: Digestive and Liver Disease
https://www.readbyqxmd.com/read/28533922/correlation-of-rapid-point-of-care-vs-send-out-fecal-calprotectin-monitoring-in-pediatric-inflammatory-bowel-disease
#12
Alexis Rodriguez, Lauren Yokomizo, Megan Christofferson, Danielle Barnes, Nasim Khavari, K T Park
AIM: To assess the correlation between the send-out enzyme-linked immuno sorbent assay (ELISA) and the point-of-care (POC) calprotectin test in pediatric inflammatory bowel disease (IBD) patients. METHODS: We prospectively collected stool samples in pediatric IBD patients for concomitant send-out ELISA analysis and POC calprotectin testing using the Quantum Blue(®) (QB) Extended immunoassay. Continuous results between 17 to 1000 μg/g were considered for comparison...
May 6, 2017: World Journal of Gastrointestinal Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/28528364/a-randomized-double-blind-placebo-controlled-trial-of-a-multi-strain-probiotic-in-treatment-of-symptomatic-uncomplicated-diverticular-disease
#13
Charlotte L Kvasnovsky, Ingvar Bjarnason, Ana Nora Donaldson, Roy A Sherwood, Savvas Papagrigoriadis
BACKGROUND: Diverticular disease is a significant burden on healthcare systems that is managed, surgically or medically, mainly as an emergency or acute condition. There are no standardized treatment recommendations for symptomatic uncomplicated disease. We hypothesized that a probiotic would reduce abdominal pain in such patients. METHODS: We conducted a single-center, double-blind, placebo-controlled trial of probiotic treatment (Symprove) in adult patients with moderate-to-severe chronic, non-acute symptomatic diverticular disease...
May 20, 2017: Inflammopharmacology
https://www.readbyqxmd.com/read/28523450/a-review-of-the-clinical-pharmacokinetics-pharmacodynamics-and-immunogenicity-of-vedolizumab
#14
REVIEW
Maria Rosario, Nathanael L Dirks, Catherine Milch, Asit Parikh, Michael Bargfrede, Tim Wyant, Eric Fedyk, Irving Fox
Vedolizumab is a humanized anti-α4β7 integrin monoclonal antibody that selectively blocks trafficking of memory T cells to inflamed gut tissue by inhibiting the α4β7-mucosal addressin cell adhesion molecule-1 (MAdCAM-1) interaction. Approved for treating patients with moderately to severely active ulcerative colitis (UC) or Crohn's disease (CD), vedolizumab is administered as a 300 mg intravenous infusion. Vedolizumab undergoes a rapid, saturable, non-linear, target-mediated elimination process at low concentrations and a slower, linear, non-specific elimination process at higher concentrations...
May 18, 2017: Clinical Pharmacokinetics
https://www.readbyqxmd.com/read/28520581/reply-to-accuracy-of-consecutive-fecal-calprotectin-measurements-to-predict-relapse-in-inflammatory-bowel-disease-patients
#15
Rocio Ferreiro-Iglesias, Manuel Barreiro-de Acosta, Juan E Dominguez-Munoz
No abstract text is available yet for this article.
May 17, 2017: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/28512287/levels-of-faecal-calprotectin-and-magnetic-resonance-enterocolonography-correlate-with-severity-of-small-bowel-crohn-s-disease-a-retrospective-cohort-study
#16
Lei Ye, Wei Chen, Bi-Qin Chen, Xing Lan, Shao-Dong Wang, Xiao-Chen Wu, Wei Huang, Fang-Yu Wang
Few studies have evaluated the usefulness of fecal calprotectin (FC) or magnetic resonance enterography (MRE) in diagnosing active Crohn's disease (CD) of the small bowel. In the study, we investigated the reliability of FC and MRE in assessing the activity of ileal CD and further explored the relationship between levels of FC and MRE scores. A total of 221 patients were diagnosed with ileal or ileo-colitis CD in our department between July 2012 and October 2016. The global magnetic resonance index of activity (MaRIA) correlated with the simple endoscopic score for CD (SES-CD) (r = 0...
May 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28511198/clinical-utility-of-fecal-calprotectin-monitoring-in-asymptomatic-patients-with-inflammatory-bowel-disease-a-systematic-review-and-practical-guide
#17
Anke Heida, K T Park, Patrick F van Rheenen
BACKGROUND: In asymptomatic patients with inflammatory bowel disease (IBD), "monitoring" involves repeated testing aimed at early recognition of disease exacerbation. We aimed to determine the usefulness of repeated fecal calprotectin (FC) measurements to predict IBD relapses by a systematic literature review. METHODS: An electronic search was performed in Medline, Embase, and Cochrane from inception to April 2016. Inclusion criteria were prospective studies that followed patients with IBD in remission at baseline and had at least 2 consecutive FC measurements with a test interval of 2 weeks to 6 months...
June 2017: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/28501098/alterations-in-intestinal-microbiota-relate-to-intestinal-failure-associated-liver-disease-and-central-line-infections
#18
Panliang Wang, Ying Wang, Lina Lu, Weihui Yan, Yijing Tao, Kejun Zhou, Jie Jia, Wei Cai
BACKGROUND: The gut microbiota plays a vital role in modulating the metabolic and immune functions of the intestines. We aimed to analyze the dysbiosis of microbiota in infants with short bowel syndrome (SBS) with different complications. PROCEDURE: We included 26 fecal samples from 18 infants with SBS during parenteral nutrition. The samples were categorized into three groups: asymptomatic, parenteral nutrition-associated liver disease (PNALD), and central line-associated bloodstream infection (CLABSI)...
May 3, 2017: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/28498159/fecal-calprotectin-is-not-affected-by-pregnancy-clinical-implications-for-the-management-of-pregnant-patients-with-inflammatory-bowel-disease
#19
Mette Julsgaard, Christian L Hvas, Richard B Gearry, Thea Vestergaard, Jan Fallingborg, Lise Svenningsen, Jens Kjeldsen, Miles P Sparrow, Signe Wildt, Jens Kelsen, Sally J Bell
BACKGROUND: Noninvasive biomarkers of inflammation for monitoring inflammatory bowel disease (IBD) are important in pregnancy. Clinical and laboratory markers are often affected by the physiological adaption that occurs during pregnancy, although, few, if any, data exist on fecal calprotectin (FC). We investigated FC concentrations in pregnant controls and IBD women, and whether FC correlated with physician global assessment (PGA), C-reactive protein (CRP), and Harvey-Bradshaw Index (HBI)/Simple Clinical Colitis Activity Index (SCCAI) before and after pregnancy, as well as during each trimester...
July 2017: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/28491862/comparison-of-fecal-calprotectin-methods-for-predicting-relapse-of-pediatric-inflammatory-bowel-disease
#20
Saranya Kittanakom, Md Sharif Shajib, Kristine Garvie, Joceline Turner, Dan Brooks, Sufian Odeh, Robert Issenman, V Tony Chetty, Joseph Macri, Waliul I Khan
Background. Pediatric inflammatory bowel disease (IBD) is on the rise worldwide. Endoscopies are necessary for IBD assessment but are invasive, expensive, and inconvenient. Recently, fecal calprotectin (FCal) was proposed as a noninvasive and specific marker of gut inflammation. We evaluated the analytical performance of three FCal assays and their clinical performance in predicting relapse in pediatric IBD. Methods. This study used 40 pediatric IBD and 40 random non-IBD patients' fecal samples. Two automated ELISAs (Bühlmann and PhiCal® Calprotectin-EIA) and an EliA (Phadia 250 EliA-Calprotectin) were used to evaluate the analytical performance...
2017: Canadian Journal of Gastroenterology & Hepatology
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