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https://www.readbyqxmd.com/read/28345842/bone-mineral-density-in-survivors-of-childhood-acute-lymphoblastic-leukemia
#1
Farzaneh Rohani, Khadijeh Arjmandi Rafsanjani, Gholamreza Bahoush, Mansoureh Sabzehparvar, Mohammad Ahmadi
Background: The objective of this study was to evaluate bone mineral density (BMD) after completion of treatment for childhood acute lymphoblastic leukemia (ALL). Methods: In this cross-sectional study, 103 survivors of ALL aged 13.5 ± 0.45 who completed their treatment at least one year earlier were enrolled. Among these, 49.5% and 51.5% received chemotherapy alone and chemotherapy plus cranial radiotherapy, respectively. Bone mineral content, BMD, and bone mineral apparent density in the lumbar spine (LS), femoral neck (FN) and forearm were assessed using dual-energy X-ray absorptiometry (DEXA)...
February 1, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/28345737/-meningeal-carcinomatosis-in-breast-cancer-from-diagnosis-to-treatment
#2
REVIEW
C Elm'hadi, Z Es Sbai, M Reda Khmamouche, M Toreis, R Tanz, H Errihani, M Ichou
The appearance of meningeal carcinomatosis in breast cancer is an event that is being reported increasingly more frequently in the literature. It seems to be related with the lengthening of the patients' lives, improved sensitivity to diagnostic imaging and impermeability of the blood-brain barrier to the chemotherapeutic agents. It is an evolutionary form that affirms the metastatic invasion of the subarachnoidal space and is correlated with limited survival. Its diagnosis is difficult, due to the lack of specificity of the clinical signs dominated by headaches, cognitive disorders and possible signs and symptoms of progressive focal lesions...
April 1, 2017: Revista de Neurologia
https://www.readbyqxmd.com/read/28345418/a-coaxial-dual-element-focused-ultrasound-probe-for-guidance-of-epidural-catheterization
#3
Guo-Chung Dong, Li-Chen Chiu, Chien-Kun Ting, Jia-Ruei Hsu, Chih-Chung Huang, Yin Chang, Gin-Shin Chen
Ultrasound guidance for epidural block has improved clinical blind-trial problems but the design of present ultrasonic probes poses operating difficulty of ultrasound-guided catheterization, increasing the failure rate. The purpose of this study was to develop a novel ultrasonic probe to avoid needle contact with vertebral bone during epidural catheterization. The probe has a central circular passage for needle insertion. Two focused annular transducers are deployed around the passage for on-axis guidance. A 17-gauge insulated Tuohy needle containing the self-developed fiber-optic-modified stylet was inserted into the back of the anesthetized pig, in the lumbar region under the guidance of our ultrasonic probe...
March 1, 2017: Ultrasonic Imaging
https://www.readbyqxmd.com/read/28345300/primary-intestinal-lymphangiectasia-multiple-detector-computed-tomography-findings-after-direct-lymphangiography
#4
Xiaoli Sun, Wenbin Shen, Xiaobai Chen, Tingguo Wen, Yongli Duan, Rengui Wang
INTRODUCTION: To analyse the findings of multiple detector computed tomography (MDCT) after direct lymphangiography in primary intestinal lymphangiectasia (PIL). METHODS: Fifty-five patients with PIL were retrospectively reviewed. All patients underwent MDCT after direct lymphangiography. The pathologies of 16 patients were confirmed by surgery and the remaining 39 patients were confirmed by gastroendoscopy and/or capsule endoscopy. RESULTS: After direct lymphangiography, MDCT found intra- and extraintestinal as well as lymphatic vessel abnormalities...
March 27, 2017: Journal of Medical Imaging and Radiation Oncology
https://www.readbyqxmd.com/read/28345071/jolt-accentuation-and-its-value-as-a-sign-in-diagnosis-of-meningitis-in-patients-with-fever-and-headache
#5
Mani Mofidi, Narges Negaresh, Davood Farsi, Mahdi Rezai, Babak Mahshidfar, Saeed Abbasi, Peyman Hafezimoghadam
OBJECTIVES: Meningitis is an important disease among the patients being visited in Emergency Departments (EDs). There are many signs to diagnose it with different sensitivity and specificity reported in previously done studies. Current study tries to evaluate diagnostic accuracy of "Jolt accentuation" in the diagnosis (Dx.) of meningitis in patients with fever and headache. MATERIALS AND METHODS: 48 adult patients, who were referred to two teaching EDs for fever and headache and were diagnosed as suspected meningitis, were included in this prospective observational study...
March 2017: Turkish Journal of Emergency Medicine
https://www.readbyqxmd.com/read/28344736/recovery-of-hip-and-back-muscle-fatigue-following-a-back-extension-endurance-test
#6
Sharon Wang-Price, Mohammad Almadan, Carissa Stoddard, Dustin Moore
Literature has not shown the minimum time required to recover from muscle fatigue after a prolonged trunk isometric contraction. The purpose of this study was to determine if the lumbar multifidus (LM) and gluteus maximus (GM) muscles would recover from fatigue after three different rest periods following performance of a back extension endurance test. Endurance time and electromyographic (EMG) activity of bilateral LM and GM muscles were collected from 12 healthy adults during a modified Biering-Sørensen test...
2017: International Journal of Exercise Science
https://www.readbyqxmd.com/read/28344159/significance-of-preoperative-planning-software-for-puncture-and-channel-establishment-in-percutaneous-endoscopic-lumbar-discectomy-a-study-of-40-cases
#7
Zhouyang Hu, Xinhua Li, Jian Cui, Xiaobo He, Cong Li, Yingchao Han, Jie Pan, Mingjie Yang, Jun Tan, Lijun Li
BACKGROUND: Preoperative planning software has been widely used in many other minimally invasive surgeries, but there is a lack of information describing the clinical benefits of existing software applied in percutaneous endoscopic lumbar discectomy(PELD). This study aimed to compare the clinical efficacy of preoperative planning software in puncture and channel establishment of PELD with routine methods in treating lumbar disc herniation (LDH). MATERIAL AND METHODS: From June 2016 to October 2016, 40 patients who had single L4/5 or L5/S1 disc herniation were divided into two groups...
March 23, 2017: International Journal of Surgery
https://www.readbyqxmd.com/read/28344074/aberrant-distributions-of-nuclear-pore-complex-proteins-in-als-mice-and-als-patients
#8
Jingwei Shang, Toru Yamashita, Yumiko Nakano, Ryuta Morihara, Xianghong Li, Tian Feng, Xia Liu, Yong Huang, Yusuke Fukui, Nozomi Hishikawa, Yasuyuki Ohta, Koji Abe
Nuclear pore complexes (NPCs) play important roles in traffic of molecules between the nucleus and cytoplasm, aberrant distributions of components of NPCs were demonstrated in C9orf72 amyotrophic lateral sclerosis (C9-ALS) patients, but it is elusive whether such abnormities are also the case with other cause of ALS disease. In the present study, we investigated the spatiotemporal distributions of RanGAP1 and 4 representative nucleoporins (GP210, NUP205, NUP107 and NUP50) of NPCs in human Cu/Zn superoxide dismutase-1 mutation transgenic (SOD1-Tg) mice and sporadic ALS patients...
March 23, 2017: Neuroscience
https://www.readbyqxmd.com/read/28343922/correlation-of-matrix-metalloproteinase-mmp-1-2-3-and-9-expressions-with-demographic-and-radiological-features-in-primary-lumbar-intervertebral-disc-disease
#9
Recep Basaran, Mehmet Senol, Seyma Ozkanli, Mustafa Efendioglu, Tuncay Kaner
Degeneration of IVD is a progressive and irreversible process and can be evaluated with immunohistochemical examination or radiological grading. MMPs are a family of proteolytic enzymes and involved in the degradation of the matrix components of the IVD. We aimed to compare MMP-1, -2, -3, and -9 expressions with demographic features, visual analogue scale (VAS), Oswestry Disability Index (ODI) and radiological (MRI) grades. The study involved 60 participants. We recorded data about age, complaint, radiological imaging, expression levels of MMP-1, -2, -3, and -9, ODI and VAS for back pain retrospectively...
March 23, 2017: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/28343742/automatic-matching-of-surgeries-to-predict-surgeons-next-actions
#10
Germain Forestier, François Petitjean, Laurent Riffaud, Pierre Jannin
OBJECTIVE: More than half a million surgeries are performed every day worldwide, which makes surgery one of the most important component of global health care. In this context, the objective of this paper is to introduce a new method for the prediction of the possible next task that a surgeon is going to perform during surgery. MATERIAL AND METHOD: We formulate the problem as finding the optimal registration of a partial sequence to a complete reference sequence of surgical activities...
March 23, 2017: Artificial Intelligence in Medicine
https://www.readbyqxmd.com/read/28343332/posterior-elements-disruption-with-hybrid-constructs-in-ais-patients-is-there-an-impact-on-proximal-junctional-kyphosis
#11
S Ghailane, Sebastien Pesenti, E Peltier, E Choufani, B Blondel, J L Jouve
PURPOSE: Proximal junctional kyphosis (PJK) is a frequent proximal adjacent segment disease following spinal fusion in adolescent idiopathic scoliosis (AIS) and its rate has been estimated to 28% in the literature. The etiology is multifactorial, and risk factors associated with PJK are controversial. The aim of this study was to demonstrate that the disruption of muscular and bony tissue above the upper instrumented vertebra (UIV) during surgery does not increase the rate of PJK in patients undergoing posterior fusion for adolescent idiopathic scoliosis...
March 25, 2017: Archives of Orthopaedic and Trauma Surgery
https://www.readbyqxmd.com/read/28343046/perioperative-hemoglobin-a1c-as-a-predictor-of-deep-infection-following-single-level-lumbar-decompression-in-patients-with-diabetes
#12
Jourdan M Cancienne, Brian C Werner, Dennis Q Chen, Hamid Hassanzadeh, Adam L Shimer
BACKGROUND CONTEXT: Although multiple studies have cited diabetes mellitus as a risk factor decreased functional outcomes, increased infectious complications, and overall increased reoperation rate following degenerative lumbar spinal surgery, few have investigated how perioperative glycemic control influences such complications. PURPOSE: The primary goal of the present study was to use a national database to evaluate the association of perioperative glycemic control as demonstrated by Hemoglobin A1c levels in patients with diabetes undergoing primary, single level decompression without concomitant fusion with the incidence of deep postoperative infection following requiring operative irrigation and debridement...
March 22, 2017: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/28342975/biomechanical-testing-of-a-peek-based-dynamic-instrumentation-device-in-a-lumbar-spine-model
#13
Christian Herren, Agnes Beckmann, Sabine Meyer, Miguel Pishnamaz, Marion Mundt, Rolf Sobottke, Andreas Prescher, Marcus Stoffel, Bernd Markert, Philipp Kobbe, Hans-Christoph Pape, Peer Eysel, Jan Siewe
BACKGROUND: The purpose of this study was to investigate the range-of-motion after posterior polyetheretherketone-based rod stabilisation combined with a dynamic silicone hinge in order to compare it with titanium rigid stabilisation. METHODS: Five human cadaveric lumbar spines with four vertebra each (L2 to L5) were tested in a temperature adjustable spine-testing set-up in four trials: (1) native measurement; (2) kinematics after rigid monosegmental titanium rod instrumentation with anterior intervertebral bracing of the segment L4/5; (3) kinematics after hybrid posterior polyetheretherketone rod instrumentation combined with a silicone hinge within the adjacent level (L3/4) and (4) kinematics after additional decompression with laminectomy of L4 and bilateral resection of the inferior articular processes (L3)...
March 18, 2017: Clinical Biomechanics
https://www.readbyqxmd.com/read/28342920/which-is-the-more-appropriate-proximal-fusion-level-for-adult-lumbar-degenerative-flat-back
#14
Jeong-Hoon Choi, Jee-Soo Jang, Hyeun-Sung Kim, Il-Tae Jang
OBJECTIVE: To determine the optimal proximal fusion level after long instrumented fusion to the sacrum for lumbar degenerative flat back. METHODS: Data from 70 patients with lumbar degenerative flat back were reviewed retrospectively. Three groups were designated according to the upper instrumented vertebrae (UIV) : Group 1 (UIV = T10 or above), Group 2 (UIV = T11 to T12), and Group 3 (UIV = L1 or below). Preoperative and postoperative pelvic parameters, degree of correction, and prevalence of proximal junctional kyphosis (PJK) and its risk factors were evaluated...
March 22, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28342919/radiation-exposure-to-the-surgeon-during-ultrasound-assisted-transforaminal-percutaneous-endoscopic-lumbar-discectomy-a-prospective-study
#15
Ruihui Wu, Xuqiang Liao, Hong Xia
PURPOSE: To determine the radiation dose to the surgeon during ultrasound-assisted transforaminal percutaneous endoscopic lumbar discectomy (transforaminal PELD) for lumbar disc herniation, and investigate whether the usage of ultrasonography could reduce the radiation exposure to surgeon. METHODS: The stages of needle insertion and foraminal plasty for transforaminal PELD were performed under ultrasound guidance and confirmed by fluoroscopy according to the standard technique by two spinal surgeons separately in 25 transforaminal PELDs (25 levels)...
March 22, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28342871/oxidative-damage-induces-apoptosis-and-promotes-calcification-in-disc-cartilage-endplate-cell-through-ros-mapk-nf-%C3%AE%C2%BAb-pathway-implications-for-disc-degeneration
#16
Yingchao Han, Xinhua Li, Meijun Yan, Mingjie Yang, Shanjin Wang, Jie Pan, Lili Jun, Jun Tan
Cartilage endplate (CEP) cell calcification and apoptosis play a vital role in the intervertebral disc degeneration (IVDD). Oxidative stress is a key factor in inducing programmed cell death and cartilage calcification. However, the cell death and calcification of cartilage endplate cells under oxidative stress have never been described. The present study investigated the apoptosis and calcification in the cartilage endplate cell under oxidative stress induced by H2O2 to understand the underlying mechanism of IVDD...
March 23, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28342707/clinical-characteristics-microbiology-and-outcomes-of-external-ventricular-drainage-associated-infections-the-importance-of-active-treatment
#17
Constantinos Tsioutis, Spyridon A Karageorgos, Soultana Stratakou, Stella Soundoulounaki, Dimitrios Karambetsos, George Kouyentakis, Achilleas Gikas
Data concerning clinical characteristics, microbiology, treatment and outcomes of external ventricular drainage-associated infections (EVDAI) are limited. All hospitalized patients with EVDAI in a University Hospital between January 2009 and December 2015 were retrospective recorded. Only the first episode per patient was included. An antibiotic was considered "active" when its pharmacokinetic properties were appropriate for EVDAI and the implicated microorganism was in vitro susceptible. During the 7-year study period, 36 EVDAI were identified...
March 22, 2017: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/28342168/bone-mass-in-boys-with-autism-spectrum-disorder
#18
Chadi A Calarge, Janet A Schlechte
To examine bone mass in children and adolescents with autism spectrum disorders (ASD). Risperidone-treated 5 to 17 year-old males underwent anthropometric and bone measurements, using dual-energy X-ray absorptiometry and peripheral quantitative computed tomography. Multivariable linear regression analysis models examined whether skeletal outcomes differed among participants with (n = 30) versus without ASD (n = 156). After adjusting for potential covariates, having ASD was associated with significantly lower trabecular bone mineral density and bone strength at the radius, and with marginally lower total body less head bone mineral content (p < 0...
March 25, 2017: Journal of Autism and Developmental Disorders
https://www.readbyqxmd.com/read/28342094/comparison-of-the-use-of-rhbmp-7-versus-iliac-crest-autograft-in-single-level-lumbar-fusion-a-meta-analysis-of-randomized-controlled-trials
#19
Fubiao Ye, Zhiyuan Zeng, Jianru Wang, Hui Liu, Hua Wang, Zhaomin Zheng
The aim of this study was to evaluate the safety and clinical effectiveness of rhBMP-7 (or osteogenic protein-1) versus that of autogenous iliac crest bone graft (ICBG) in single-level posterolateral fusion (PLF) of the lumbar spine. A systematic search of all articles published through July 1, 2016 was conducted in databases such as PubMed, EMBASE, Scopus, and the Cochrane Collaboration Library. Randomized controlled trials (RCTs) that compared rhBMP-7 with ICBG for the treatment of single-level degenerative spondylolisthesis, provided the fusion rate, clinical success rate, safety and adverse events report, operation time, and hospital stay durations as the outcome were assessed...
March 24, 2017: Journal of Bone and Mineral Metabolism
https://www.readbyqxmd.com/read/28341925/relationship-between-serum-adiponectin-and-bone-mineral-density-in-male-patients-with-obstructive-sleep-apnea-syndrome
#20
Dong-Dong Chen, Jie-Feng Huang, Qi-Chang Lin, Gong-Ping Chen, Jian-Ming Zhao
PURPOSE: Obstructive sleep apnea syndrome (OSAS) is reported to have an association with bone mineral density (BMD). However, the underlying mechanism is far from clear. The aim of this study was to investigate the relationship between OSAS, bone turnover markers, and BMD and to evaluate the effect of adiponectin on BMD in patients with OSAS. METHODS: Seventy-one male patients with OSAS and 13 male control subjects were enrolled in this study. Serum adiponectin, calcium, phosphorus, 25-hydroxyvitamin-D3, β-isomerized form C-terminal telopeptide of type I collagen, osteocalcin, and procollagen type 1 N-propeptide were measured in all subjects, and BMD was evaluated by dual-energy X-ray absorptiometry (DEXA) in the lumbar spine (L1-L4), the femoral neck, and the hip total...
March 25, 2017: Sleep & Breathing, Schlaf & Atmung
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