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Cyclodextrin

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https://www.readbyqxmd.com/read/29223359/in-niemann-pick-c1-mouse-models-glial-only-expression-of-the-normal-gene-extends-survival-much-further-than-do-changes-in-genetic-background-or-treatment-with-hydroxypropyl-beta-cyclodextrin
#1
Craig A Marshall, Dawn E Watkins-Chow, Giampiero Palladino, Gail Deutsch, Keshav Chandran, William J Pavan, Robert P Erickson
The Npc1nmf164 allele of Npc1 provides a mouse model for Niemann-Pick disease type C1 (NPC1), a genetic disease known to have a widely variable phenotype. The transfer of the Npc1nmf164 mutation from the C57BL/6J inbred strain to the BALB/cJ inbred strain increased the mean lifespan from 117.8days to 153.1days, confirming that the severity of the NPC1 phenotype is strongly influenced by genetic background. The transfer of another Npc1 allele, Npc1nih, to this background also extended survival of the homozygotes indicating that the modifying effect of BALB/cJ is not limited to a single allele of Npc1...
December 6, 2017: Gene
https://www.readbyqxmd.com/read/29219743/building-a-polysaccharide-hydrogel-capsule-delivery-system-for-control-release-of-ibuprofen
#2
Zhi Chen, Ting Wang, Qing Yan
Development of a delivery system which can effectively carry hydrophobic drugs and have pH response is becoming necessary. Here we demonstrate that through preparation of β-cyclodextrin polymer (β-CDP), a hydrophobic drug molecule of ibuprofen (IBU) was incorporated into our prepared β-CDP inner cavities, aiming to improve the poor water solubility of IBU. A core-shell capsule structure has been designed for achieving the drug pH targeted and sustained release. This delivery system was built with polysaccharide polymer of Sodium alginate (SA), sodium carboxymethylcellulose (CMC) and hydroxyethyl cellulose (HEC) by physical cross-linking...
December 8, 2017: Journal of Biomaterials Science. Polymer Edition
https://www.readbyqxmd.com/read/29217477/activation-of-hepatic-nogo-b-receptor-expression-a-new-anti-liver-steatosis-mechanism-of-statins
#3
Wenwen Zhang, Xiaoxiao Yang, Yuanli Chen, Wenquan Hu, Lipei Liu, Xiaomeng Zhang, Mengyang Liu, Lei Sun, Ying Liu, Miao Yu, Xiaoju Li, Luyuan Li, Yan Zhu, Qing Robert Miao, Jihong Han, Yajun Duan
Deficiency of hepatic Nogo-B receptor (NgBR) expression activates liver X receptor α (LXRα) in an adenosine monophosphate-activated protein kinase α (AMPKα)-dependent manner, thereby inducing severe hepatic lipid accumulation and hypertriglyceridemia. Statins have been demonstrated non-cholesterol lowering effects including anti-nonalcoholic fatty liver disease (NAFLD). Herein, we investigated if the anti-NAFLD function of statins depends on activation of NgBR expression. In vivo, atorvastatin protected apoE deficient or NgBR floxed, but not hepatic NgBR deficient mice, against Western diet (WD)-increased triglyceride levels in liver and serum...
December 4, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29214230/cytotoxicity-of-endocytosis-and-efflux-inhibitors-in-the-bewo-cell-line
#4
Mansi Shah, Luke Bourner, Shariq Ali, Sanaalarab Al-Enazy, Erik Rytting
Aims: The purpose of this study was to determine the cell viability and cytotoxicity of various endocytosis and efflux inhibitors which can be used to determine transport and uptake mechanisms in the BeWo (b30 clone) human placental trophoblast cell line. Ethanol and dimethylsulfoxide (DMSO) were also studied since they are often used as cosolvents for administration of these inhibitors. Methodology: The water-soluble tetrazolium-1 (WST-1) assay was used to quantify cell viability and the lactate dehydrogenase (LDH) assay was used to determine cytotoxicity...
2017: Journal of Pharmaceutical Research International
https://www.readbyqxmd.com/read/29213055/inhibiting-mevalonate-pathway-enzymes-increases-stromal-cell-resilience-to-a-cholesterol-dependent-cytolysin
#5
Sholeem Griffin, Giulio Preta, Iain Martin Sheldon
Animal health depends on the ability of immune cells to kill invading pathogens, and on the resilience of tissues to tolerate the presence of pathogens. Trueperella pyogenes causes tissue pathology in many mammals by secreting a cholesterol-dependent cytolysin, pyolysin (PLO), which targets stromal cells. Cellular cholesterol is derived from squalene, which is synthesized via the mevalonate pathway enzymes, including HMGCR, FDPS and FDFT1. The present study tested the hypothesis that inhibiting enzymes in the mevalonate pathway to reduce cellular cholesterol increases the resilience of stromal cells to PLO...
December 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29212376/a-novel-ion-activated-in-situ-gelling-ophthalmic-delivery-system-based-on-kappa-carrageenan-for-acyclovir
#6
Pingfei Li, Shu Wang, Haoyuan Chen, Shiming Zhang, Shihui Yu, Yuenan Li, Mengsuo Cui, Weisan Pan, Xinggang Yang
The aim of this study was to prepare and evaluate ion-activated in-situ gel ophthalmic drug delivery system based on kappa-carrageenan (KC), using acyclovir as a model drug, hydroxypropyl methylcellulose (HPMC) as the viscosity agent and hydroxypropyl-β-cyclodextrin (HP-β-CD) as the penetration enhancer. The two ternary phase diagrams exhibited the effect of K+ and Ca2+ on the sol-to-gel transition, which turned out that KC was more sensitive to K+. The optimal ophthalmic matrix (prepared from KC and HPMC) was optimized with in-vitro drug release test...
December 6, 2017: Drug Development and Industrial Pharmacy
https://www.readbyqxmd.com/read/29211341/chiral-separation-of-lenalidomide-by-liquid-chromatography-on-polysaccharide-type-stationary-phases-and-by-capillary-electrophoresis-using-cyclodextrin-selectors
#7
Zoltán-István Szabó, Mohammadhassan Foroughbakhshfasaei, Réka Gál, Péter Horváth, Balázs Komjáti, Béla Noszál, Gergő Tóth
Complementary techniques were applied for the investigation of the chiral recognition and enantiomeric resolution of lenalidomide, using various cyclodextrins and polysaccharides as chiral selectors. The high-performance liquid chromatography enantioseparation of the anticancer drug was achieved using polysaccharide-type chiral stationary phases in polar organic mode. Elution order and absolute configuration were elucidated by combined circular dichroism spectroscopy and time-dependent density functional theory calculations after the isolation of pure enantiomers...
December 6, 2017: Journal of Separation Science
https://www.readbyqxmd.com/read/29210562/methacrylate-stitched-%C3%AE-cyclodextrin-embedded-with-nanogold-nanotitania-a-skin-adhesive-device-for-enhanced-transdermal-drug-delivery
#8
Thayyath Sreenivasan Anirudhan, Syam S Nair, Athira V Sasidharan
Transdermal (TD) drug delivery is an attractive technique for drug delivery compared to oral and intravenous injection. However the permeation of drug molecules across the skin is difficult due to the presence of highly ordered lipid barrier. This investigation details the development of a novel TD system, which has the potential to simultaneously enhance the skin permeability and adhesion behavior. Ibuprofen (IP) was selected as model drug. The ability of gold nanoparticle (AuNP) and hydrophobic titanium nanotube (TNT) to enhance the skin permeability was explored...
December 6, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29207048/tlr4-promotes-the-expression-of-hif-1%C3%AE-by-triggering-reactive-oxygen-species-in-cervical-cancer-cells-in%C3%A2-vitro-implications-for-therapeutic-intervention
#9
Xiao Yang, Gan Tao Chen, Yan Qing Wang, Shu Xian, Li Zhang, Shao Ming Zhu, Feng Pan, Yan Xiang Cheng
The present study investigated the mechanism underlying Toll-like receptor 4 (TLR4)-mediated stimulation of hypoxia-inducible factor-1α (HIF-1α) activity and its association with reactive oxygen species (ROS) in cervical cancer cells. SiHa cells were cultured and randomized to control, lipopolysaccharide (LPS), methyl-β-cyclodextrin (MβCD)+LPS, ammonium pyrrolidinedithiocarbamate (PDTC)+LPS, ST2825+LPS and small interfering (si) RNA TLR4+LPS treatment groups. Cell proliferation was quantified using an MTT assay, cell cloning was performed using soft agar colony formation and HIF-1α expression was detected by immunocytochemical staining and western blot analyses...
November 20, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29203151/population-pharmacokinetic-evaluation-of-adv6209-an-innovative-oral-solution-of-midazolam-containing-cyclodextrin
#10
Frédéric Marçon, Catherine Guittet, Maria A Manso, Ingrid Burton, Luc-André Granier, Philippe Jacqmin, Hervé Dupont
INTRODUCTION: In the absence of a licensed formulation in many countries worldwide, ADV6209, an innovative 2mg/mL oral solution of midazolam containing cyclodextrin, has been developed for moderate sedation in paediatric patients. Population pharmacokinetics for ADV6209 is reported. METHODS: Plasma concentration data were collected from 37 paediatric patients and 12 healthy adults recruited in a single dose, open-label phase II pharmacokinetic study and in a single dose, randomised, open-label two-period crossover bioavailability study, respectively...
December 1, 2017: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29202646/submucosal-diclofenac-for-acute-postoperative-pain-in-third-molar-surgery-a-randomized-controlled-clinical-trial
#11
P Gorecki, K D Rainsford, P Taneja, Y Bulsara, D Pearson, D Saund, B Ahmed, T Dietrich
Diclofenac sodium is a widely used nonsteroidal anti-inflammatory drug (NSAID) for relief of inflammatory pain. A recent formulation combines this drug with hydroxypropyl-β-cyclodextrin (HPβCD) to improve its solubility and to enable subcutaneous administration. Previous studies confirmed the efficacy of this combination. This study's aim was to evaluate the efficacy, safety, and local tolerability of diclofenac HPβCD administered as a local submucosal injection prior to lower third molar surgery. We conducted a prospective, randomized, double-blind, placebo-controlled, parallel-group phase II single-center study...
December 1, 2017: Journal of Dental Research
https://www.readbyqxmd.com/read/29201100/single-step-purification-of-novel-thermostable-and-chelator-resistant-amylase-from-bacilluslicheniformis-rm44-by-affinity-chromatography
#12
Ayesha Siddiqui, Mustafa Kamal, Seyed Abdulmajid Ayatollahi, Mohsin Ali, Mansoor Ahmed
Bacillus licheniformis RM44 was isolated from hot spring near Karachi and screened for the production of extracellular amylase Amy RM44. Amy RM44 was purified to homogeneity on a single step by affinity chromatography using insoluble corn starch. The molecular weight of Amy RM44 was estimated to be 66 kDa by SDS-PAGE and zymographic analysis. Nine fold purification was achieved with the specific activity of 870 U/mg that provides the total yield of the enzyme up to 31%. Studies on purified AmyRM44 characterization revealed that the optimum temperature of enzyme was 100 ºC...
2017: Iranian Journal of Pharmaceutical Research: IJPR
https://www.readbyqxmd.com/read/29200826/anticancer-effect-of-dentatin-and-dentatin-hydroxypropyl-%C3%AE-cyclodextrin-complex-on-human-colon-cancer-ht-29-cell-line
#13
Ashwaq Shakir Al-Abboodi, Abdullah Rasedee, Ahmad Bustamam Abdul, Yun Hin Taufiq-Yap, Wafaa Abd Alwahed Alkaby, Mostafa Saddam Ghaji, Peter M Waziri, Mothanna Sadiq Al-Qubaisi
Introduction: Dentatin (DEN) (5-methoxy-2, 2-dimethyl-10-(1, 1-dimethyl-2propenyl) dipyran-2-one), a natural compound present in the roots of Clausena excavata Burm f, possesses pro-apoptotic and antiproliferative effects in various cancer cells. Because of its hydrophobicity, it is believed that its complexation with hydroxy-β-cyclodextrin (HPβCD) will make it a potent inhibitor of cancer cell growth. In the current work, the molecular mechanisms of apoptosis induced by DEN and DEN-HPβCD complex were demonstrated in human colon HT-29 cancer cells...
2017: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/29198147/optimisation-of-%C3%AE-cyclodextrin-inclusion-complexes-with-natural-antimicrobial-agents-thymol-carvacrol-and-linalool
#14
Ghofran Al-Nasiri, Marlene J Cran, Andrew J Smallridge, Stephen W Bigger
Beta-cyclodextrin (β-CD) inclusion complexes with naturally derived antimicrobial (AM) agents: thymol, carvacrol, and linalool were prepared using a co-precipitation technique. Conditions including solvent composition, temperature, reaction time, and total solvent volume were investigated to optimise the inclusion efficiency (IE) and yield. Electrospray ionization mass spectrometry was used to confirm the formation of the thymol/β-CD complex and gas chromatography was used to quantify the amount AM agent that was encapsulated, absorbed onto the surface, or remaining in the filtered solvent...
December 4, 2017: Journal of Microencapsulation
https://www.readbyqxmd.com/read/29197175/pharmacokinetics-of-diclofenac-and-hydroxypropyl-%C3%AE-cyclodextrin-hp%C3%AE-cd-following-administration-of-injectable-hp%C3%AE-cd-diclofenac-in-subjects-with-mild-to-moderate-renal-insufficiency-or-mild-hepatic-impairment
#15
Douglas A Hamilton, Cynthia C Ernst, William G Kramer, Donna Madden, Eric Lang, Edward Liao, Peter G Lacouture, Atulkumar Ramaiya, Daniel B Carr
Given their established analgesic properties, nonsteroidal anti-inflammatory drugs (NSAIDs) represent an important postoperative pain management option. This study investigated: (1) the effects of mild or moderate renal insufficiency and mild hepatic impairment on the pharmacokinetics (PK) of diclofenac and hydroxypropyl-β-cyclodextrin (HPβCD) following administration of the injectable NSAID HPβCD-diclofenac; and (2) the PK of HPβCD following administration of HPβCD-diclofenac and intravenous itraconazole formulated with HPβCD in healthy adults...
December 2, 2017: Clinical Pharmacology in Drug Development
https://www.readbyqxmd.com/read/29191522/cyclodextrin-sirna-conjugates-as-versatile-gene-silencing-agents
#16
Meenakshi Malhotra, Matt Gooding, James C Evans, Daniel O'Driscoll, Raphael Darcy, Caitriona O'Driscoll
Functional siRNAs (luciferase and PLK1) have been conjugated to β-cyclodextrin and the ability of the conjugates to retain gene knockdown activity has been assessed by delivery to cancer cell lines using various formulations. Initially two formulations used complexation with polycations, namely Lipofectamine 2000 and an amphiphilic polycationic cyclodextrin. Gene knockdown results for human glioblastoma cells (U87) and prostate cancer cells (PC3, DU145) showed that conjugation to the cyclodextrin did not reduce gene silencing by the RNA...
November 27, 2017: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29191520/novel-controlled-ionic-gelation-strategy-for-chitosan-nanoparticles-preparation-using-tpp-%C3%AE-cd-inclusion-complex
#17
Anjali Pant, Jeetendra Singh Negi
The aim of this study was to develop a novel controlled ionic gelation strategy for chitosan nanoparticle preparation to avoid particle aggregation tendency associated with conventional ionic gelation process. In this study inclusion complexation behaviour of sodium tripolyphosphate (TPP) with beta cyclodextrin (β-CD) has been investigated. The TPP-β-CD inclusion complex was characterized by FT-IR, XRD and DSC techniques. The complexation behaviour was also investigated by molecular docking study. The results showed that the TPP molecule formed inclusion complex with β-CD...
November 27, 2017: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29190466/thermo-responsive-molecularly-imprinted-polymer-containing-magnetic-nanoparticles-synthesis-characterization-and-adsorption-properties-for-curcumin
#18
Roya Sedghi, Mehrasa Yassari, Bahareh Heidari
A novel intelligent thermoresponsive-magnetic molecularly imprinted polymer (TMMIP) nanocomposite based on N-isopropylacrylamide (NIPAM) & Fe3O4 was designed for the controlled & sustained release of Curcumin (CUR) with the ability to response external stimulus. The TMMIP nanocomposite was prepared using acryl functionalized β-cyclodextrin (β-CD) and NIPAM as functional monomers and CUR as target molecule. The recognition cavities which caused by host-guest interactions had direct influence to enhanced drug loading and sustained release of CUR...
November 22, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/29187674/nitrative-dna-damage-in-cultured-macrophages-exposed-to-indium-oxide
#19
Tahmina Afroz, Yusuke Hiraku, Ning Ma, Sharif Ahmed, Shinji Oikawa, Shosuke Kawanishi, Mariko Murata
OBJECTIVES: Indium compounds are used in manufacturing displays of mobile phones and televisions. However, these materials cause interstitial pneumonia in exposed workers. Animal experiments demonstrated that indium compounds caused lung cancer. Chronic inflammation is considered to play a role in lung carcinogenesis and fibrosis induced by particulate matters. 8-Nitroguanine (8-nitroG) is a mutagenic DNA lesion formed during inflammation and may participate in carcinogenesis. To clarify the mechanism of carcinogenesis, we examined 8-nitroG formation in indium-exposed cultured cells...
November 29, 2017: Journal of Occupational Health
https://www.readbyqxmd.com/read/29185164/extracellular-chromone-derivatives-in-cell-cultures-of-pimpinella-anisum-influence-of-elicitation-with-methyl-jasmonate-and-2%C3%AE-methyl-cyclodextrins
#20
Camilo Soto-Argel, Diego Hidalgo, Javier Palazon, Purificación Corchete
OBJECTIVES: To explore the potentiality of undifferentiated Pimpinella anisum L. cell cultures for the production of secondary metabolites by means of elicitation. RESULTS: Two chromone compounds were secreted to the medium of undifferentiated cultures of P. anisum: 4-methoxyfuro[3,2-g]chromen-7-one, known as bergapten, which is constitutive to anise, and 5-hydroxy-7-methoxy-2-methylchromen-4-one, the rare chromone eugenin, not yet described in P. anisum. Caffeoyl quinic acid species were also identified in the biomass...
November 28, 2017: Biotechnology Letters
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