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Jiun-Wen Hu, Mei-Wen Yen, Ae-June Wang, I-Ming Chu
Cyclodextrins (CDs) coupled with oils forms an insoluble inclusion complex that is able to adsorb to the interface between oils and aqueous phases; it thereby stabilizes Pickering emulsions. Three types of oils (triglyceride, linear chain oil, and ring-structured oil) were chosen to work with CDs to prepare bupivacaine (BPC)-encapsulated Pickering emulsions. We also investigated the relationship between oils and CDs; as well as their influences on stability, drug-releasing capability and skin permeability. Particle sizes and microstructures were determined by dynamic light scattering and scanning electron microscopy, respectively...
October 4, 2017: Colloids and Surfaces. B, Biointerfaces
Juanjuan Gao, Jingkun Fang, Xuehai Ju, Weiqing Zhu, Xuezhen Lin, Shupeng Zhang, Chuang Ma, Haiou Song
An electrochemically active sensing nanomaterial (denoted as CD-MPEA-NG) has been successfully constructed by an hierarchical self-assembly of cyclodextrin (CD) and N, N-dimethyl-4-(phenylethynyl)aniline (MPEA) on N-doped graphene (NG) in a low-temperature hydrothermal process. The unique nanostructure of the high-performance CD-MPEA-NG was confirmed by utilizing the Fourier transform infrared spectra, an X-ray diffractometer, a differential pulse voltammetry (DPV), etc. In particular, the method of density functional theory with dispersion energy (DFT-D) of wB97XD/LanL2DZ was employed to optimize and describe the face-to-face packing structure of heterodimers of NG and MPEA...
October 16, 2017: ACS Applied Materials & Interfaces
Laura Straub, Darío González-Abradelo, Cristian A Strassert
A supramolecular array consisting of polyvinylpyridine decorated with adamantyl-substituted Pt(ii) complexes is described. Upon complexation of the adamantyl units with cyclodextrins, a transfer into the aqueous phase can be achieved leading to an oxygen-insensitive phosphorescence. The unique properties arise from a diffusional shielding of the emitters from the environment provided by the compact self-assembled array.
October 16, 2017: Chemical Communications: Chem Comm
Xiao Xi Yang, Chun Mei Li, Yuan Fang Li, Jian Wang, Cheng Zhi Huang
The diseases attributable to viruses remain a global burden. The respiratory syncytial virus (RSV), which is considered as the major viral pathogen of the lower respiratory tract of infants, has been implicated in severe lung disease. In this contribution, we developed a β-cyclodextrin (CD) functionalized graphene oxide (GO) composite, which displayed excellent antiviral activity and could load curcumin efficiently. RSV, a negative-sense single-stranded enveloped RNA virus, was employed as a model virus to investigate the antiviral activity of multifunctional GO...
October 16, 2017: Nanoscale
Ambar S Jimenez, Francesca Jaramillo, Usha D Hemraz, Yaman Boluk, Karina Ckless, Rajesh Sunasee
Cellulose nanocrystals (CNCs) have emerged as promising candidates for a number of bio-applications. Surface modification of CNCs continues to gain significant research interest as it imparts new properties to the surface of the nanocrystals for the design of multifunctional CNCs-based materials. A small chemical surface modification can potentially lead to drastic behavioral changes of cell-material interactions thereby affecting the intended bio-application. In this work, unmodified CNCs were covalently decorated with four different organic moieties such as a diaminobutane fragment, a cyclic oligosaccharide (β-cyclodextrin), a thermoresponsive polymer (poly[N-isopropylacrylamide]), and a cationic aminomethacrylamide-based polymer using different synthetic covalent methods...
2017: Nanotechnology, Science and Applications
Wenjing Lin, Xiaofang Zhang, Long Qian, Na Yao, Ya Pan, Lijuan Zhang
Current researches are mainly trend to address the development of multi-functional nanocarriers which could precisely reach the disease sites, release drugs in a controlled-manner and act as an imaging agent for both diagnosis and targeted therapy. In this study, a pH-sensitive theranostic nanoplatform as a promising dual-functional nanovector for tumor therapy and CT imaging was developed. 21-arm star like triblock polymerof β-cyclodextrin-{poly(-caprolactone)-poly(2-aminoethyl methacrylate)-poly[poly(ethylene glycol) methyl ether methacrylate]}21 [β-CD-(PCL-PAEMA-PPEGMA)21] with stable unimolecular micelles formed in aqueous solution was firstly synthesized by combined ROP with ARGET ATRP techniques, and then were used as template for fabrication of gold nanoparticles (AuNPs) with uniform sizes and excellent colloidal stability in situ, followed by the encapsulation of doxorubicin (DOX) with maximum entrapment efficiency up to 60% to generate the final product β-CD-(PCL-PAEMA-PPEGMA)21/AuNPs/DOX...
October 15, 2017: Biomacromolecules
Le Sun, Bing Zhang, Jin Sun
This study intended to evaluate the effect of cyclodextrins on the apparent solubility and permeability of lipophilic drugs under physiological conditions and establish in silico model to choose the optimal amount of cyclodextrins for cyclodextrin-containing oral formulations. In order to study the effect of cyclodextrins under physiological conditions, bile salts and lecithin were added into the rat intestinal perfusion solution to simulate the fasted intestinal fluid. In addition, the in vivo oral absorption performances of cyclodextrin-containing formulations were simulated by gastrointestinal simulation technology based on the advanced compartmental absorption and transit model (ACAT)...
October 12, 2017: Journal of Pharmaceutical Sciences
Man Li, You Li, Ke Peng, Ying Wang, Tao Gong, Zhirong Zhang, Qin He, Xun Sun
Intranasal mRNA vaccination provides immediate immune protection against pandemic diseases. Recent studies have shown that diverse forms of polyethyleneimine (PEI) have potent mucosal adjuvant activity, which could significantly facilitate the delivery of intranasal mRNA vaccines. Nevertheless, optimizing the chemical structure of PEI to maximize its adjuvanticity and decrease its toxicity remains a challenge. Here we show that the chemical structure of PEI strongly influences how well nanocomplexes of PEI and mRNA migrate to the lymph nodes and elicit immune responses...
October 10, 2017: Acta Biomaterialia
Jingyi Zhang, Donghao Liu, Xiaoyan Meng, Yi Shi, Ruya Wang, Deli Xiao, Hua He
In this study, a novel solid phase extraction based on porous magnetic graphene oxide-cyclodextrin polymers (MGO-CD) was developed with aromatic linker and used for the simultaneous extraction and preconcentration of trace antiepileptic drugs in plasma. The characteristics of MGO-CD were assessed by Fourier transform infrared spectroscopy (FT-IR), Brunauer-Emmett-Teller surface areas (BET), Transmission Electron Microscope (TEM), Scanning Electron Microscope (SEM), X-ray diffraction (XRD) and vibrating sample magnetometer (VSM)...
October 4, 2017: Journal of Chromatography. A
Xiaoxuan Li, Xiaobin Yao, Yin Xiao, Yong Wang
A novel native cyclodextrin (CD) chiral stationary phase (CSP) with single triazole-bridge at CD C2 position (CSP1) was prepared by anchoring mono(2(A)-azido-2(A)-deoxy)-β-CD onto alkynyl silica via click chemistry. The effect of CD orientation on single layer CD-CSP's enantioseparation was comprehensively investigated using CSP1 (reversed orientation) and our previously reported CSP2 (C6 single triazole-bridge, normal orientation) as well as a commercial CD-CSP (Cyclobond I 2000, hybrid orientation) by separating several groups of analytes in chiral high performance liquid chromatography...
October 16, 2017: Analytica Chimica Acta
Jingyi Zhang, Donghao Liu, Yi Shi, Chen Sun, Muchuan Niu, Ruya Wang, Fan Hu, Deli Xiao, Hua He
In this research, a novel insoluble sorbent based on cyclodextrin and rigid aromatic groups tetrafluoroacetonitrile was designed for dispersive insoluble solid-phase extraction (DSPE). Due to its high adsorption capacity, this obtained polymer was applied to separation and concentration of trace quinolones in wastewater before HPLC determination. Various parameters influencing the extraction performance were studied and optimized. A DSPE approach coupled with high performance liquid chromatography was developed for the determination of four quinolones in wastewater samples...
October 2, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
Zhao Yuqing, Xing Yi, Li Lihua, Ma Juanjuan
Optical sensing for cysteine (Cys) recognition is an interesting topic due to Cys biological participation. In this paper, two rhodamine-based chemosensors were designed for Cys optical sensing. For chemosensor photostability improvement, up-conversion nanocrystals were synthesized and used as excitation host. These nanocrystals were modified with a phase transfer reagent α-cyclodextrin (α-CD) to improve their compatibility with chemosensors. An efficient energy transfer from these nanocrystals to chemosensors under 980nm radiation was observed and confirmed by spectral match analysis, energy transfer radius calculation and emission decay lifetime comparison...
October 4, 2017: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
Xiaojing Li, Qian Zhao, Xin Wang, Yongtao Li, Qixing Zhou
Soil contaminated by aged petroleum hydrocarbons is faced with scarcity of electron acceptors, low activity of functional microbes and inefficient electron transfer, which hinder the bioremediation application. The soil microbial fuel cell (MFC) simultaneously solves these problems with bioelectricity production. In this study, five types of surfactants were introduced to enhance the bioavailability of aged petroleum hydrocarbon in soils. The ampholytic surfactant (lecithos) was optimal due to the highest bioelectricity generation (0...
October 7, 2017: Journal of Hazardous Materials
Lin Liu, Xiangru Feng, Yueting Pei, Jinze Wang, Jianxun Ding, Li Chen
Supramolecular hydrogels (SHGs) built from inclusion complex of macrocyclic compound α-cyclodextrin (α-CD) and poly(ethylene glycol) (PEG) have attracted much interest due to their excellent biocompatibility and great potential for biomedical applications. In this work, the hydrogen bond of nucleic acid was introduced into the above-mentioned SHG by syntheses of nucleobase guanine/cytosine (G/C)-terminated PEG (G-PEG-G/C-PEG-C). The base-pairing interaction between G and C as an additional network junction effectively enhanced storage moduli (G's) of the hydrogels...
January 1, 2018: Materials Science & Engineering. C, Materials for Biological Applications
Yaqi Yao, Li Zhou, Meng Li, Xingjie Guo
Chlorpheniramine is a potent antihistaminic administered as a racemic mixture, while its clinical activity is mainly associated with the S-enantiomer. In this study, a sensitive and rapid on-line preconcentration capillary electrophoresis (CE) method, cation-selective exhaustive injection (CSEI) and sweeping method was established and validated for the analysis of two chlorpheniramine enantiomers. Parameters influencing separation and enhancement efficiency were investigated, including cyclodextrin (CD) types and concentration, background electrolyte pH, type and content of organic modifier, injection time of water plug, injection time and voltage of sample...
September 18, 2017: Journal of Pharmaceutical and Biomedical Analysis
Chutimon Muankaew, Thorsteinn Loftsson
Cyclodextrins (CDs) are recognised as promising pharmaceutical excipients due to their unique ability to form water-soluble inclusion complexes with various poorly soluble compounds. The numerous investigations on CDs and their use in nanomedicine have received considerable attention in the last three decades, leading to the rapid development of new CD-containing formulations that significantly facilitate targeted drug delivery and controlled drug release, with consequent improvements in drug bioavailability...
October 10, 2017: Basic & Clinical Pharmacology & Toxicology
D Sechet, Z Kaya, T-A Phan, M Jouffroy, E Bentouhami, D Armspach, D Matt, L Toupet
Aza-capped, methylated cyclodextrins (CDs) were obtained in high yields by reacting the soft nitrogen nucleophile 2-nitrobenzenesulfonamide with either A,B-dimesylated CDs in basic media or their diol analogues under Mitsunobu reaction conditions followed by deprotection with thiophenol. A methyl pyridine substituent was grafted on the N atom of these secondary amines. When built on an α-CD scaffold, the resulting tertiary amine no longer undergoes nitrogen inversion at room temperature and behaves as a confining ligand, opening the way to intra-cavity metal complexation and promoting the formation of supramolecular helices...
October 12, 2017: Chemical Communications: Chem Comm
Antonio Salgado, Elene Tatunashvili, Ann Gogolashvili, Bezhan Chankvetadze, Federico Gago
NMR spectroscopy experiments, molecular dynamics simulations, and theoretical chemistry calculations provide insight into the structural and energetic determinants of the distinct binding of clenpenterol enantiomers to two cyclodextrins and the migration order reversal of their respective inclusion complexes in capillary electrophoresis.
October 12, 2017: Physical Chemistry Chemical Physics: PCCP
Deiber Olivera-Severo, Augusto F Uberti, Miguel S Marques, Marta T Pinto, Maria Gomez-Lazaro, Céu Figueiredo, Marina Leite, Célia R Carlini
Helicobacter pylori is a pathogen involved in gastric diseases such as ulcers and carcinomas. H. pylori's urease is an important virulence factor produced in large amounts by this bacterium. In previous studies, we have shown that this protein is able to activate several cell types like neutrophils, monocytes, platelets, endothelial cells, and gastric epithelial cells. Angiogenesis is a physiological process implicated in growth, invasion and metastization of tumors. Here, we have analyzed the angiogenic potential of H...
2017: Frontiers in Microbiology
Teresa Vinuesa, Rocio Herráez, Laura Oliver, Elisa Elizondo, Argia Acarregui, Amaia Esquisabel, Jose Luis Pedraz, Nora Ventosa, Jaume Veciana, Miguel Viñas
This article describes the characterization of various encapsulated formulations of benznidazole, the current first-line drug for the treatment of Chagas disease. Given the adverse effects of benznidazole, safer formulations of this drug have a great interest. In fact, treatment of Chagas disease with benznidazole has to be discontinued in as much as 20% of cases due to side effects. Furthermore, modification of delivery and formulations could have potential effects on the emergence of drug resistance. The trypanocidal activity of new nanostructured formulations of benznidazole to eliminate Trypanosoma cruzi was studied in vitro as well as their toxicity in two cultured mammalian cell lines (HepG2 and Fibroblasts)...
October 2, 2017: American Journal of Tropical Medicine and Hygiene
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