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Cyclodextrin

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https://www.readbyqxmd.com/read/27913241/evaluation-of-highly-branched-cyclic-dextrin-in-inhalable-particles-of-combined-antibiotics-for-the-pulmonary-delivery-of-anti-tuberculosis-drugs
#1
Kazunori Kadota, Arisa Senda, Hideaki Tagishi, John Oluwasogo Ayorinde, Yuichi Tozuka
This work aims to identify a suitable formulation for the pulmonary delivery of combinations of inhalational drugs using highly branched cyclic dextrin (HBCD) macromolecules. We compared the effectiveness between powders prepared from HBCD with those prepared from five alternative excipients (lactose, maltose, sucrose, β-cyclodextrin and methyl β-cyclodextrin) in the pulmonary delivery of a single-dosage form of two anti-tuberculosis drugs (isoniazid and rifampicin). Fine particles of untreated active pharmaceutical ingredients (APIs) and combination products using excipients were prepared by spray drying...
November 29, 2016: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/27910740/oral-squamous-cell-carcinoma-current-treatment-strategies-and-nanotechnology-based-approaches-for-prevention-and-therapy
#2
Sankalp A Gharat, Munira Momin, Chintan Bhavsar
Oral squamous cell carcinoma (OSCC) is the most common type of oral cancer; it involves damage to oral epithelial cells due to accumulation of multiple genetic mutations in the cells. OSCC remains major cause of morbidity and mortality in patients with head and neck cancers. Tobacco, smoking, alcohol consumption alone or with chewing tobacco, and betel quid are potential carcinogens contributing to the high occurrence of OSCC. Current treatment modalities for OSCC like chemoradiotherapy, surgery, EGFR inhibitors and COX-2 inhibitors, and photodynamic therapy have led to the major problems related to non-specific cell death...
2016: Critical Reviews in Therapeutic Drug Carrier Systems
https://www.readbyqxmd.com/read/27910224/separating-and-identifying-the-four-stereoisomers-of-methyl-jasmonate-by-rp-hplc-and-using-cyclodextrins-in-a-novel-way
#3
Adrián Matencio, Mario J Bermejo-Gimeno, Francisco García-Carmona, José Manuel López-Nicolás
INTRODUCTION: Several authors have reported on the different bioactivities of methyl jasmonate (MeJA) stereoisomers. However, no simple, precise and cheap method for separating and identifying them using reversed-phase high performance liquid chromatography (RP-HPLC) has been developed. OBJECTIVE: (1) To create a simple, precise and cheap method for separating and identifying the four stereoisomers present in commercial racemic mixtures of MeJA and (2) to identify the four stereoisomers using molecular docking techniques and coinjection...
December 2, 2016: Phytochemical Analysis: PCA
https://www.readbyqxmd.com/read/27910216/capillary-electrophoresis-as-tool-for-diastereomeric-separation-in-a-trichilia-catigua-fraction
#4
Ana Luiza Sereia, Renata Longhini, Gisely Cristiny Lopes, João Carlos Palazzo de Mello
INTRODUCTION: The tree Trichilia catigua, popularly known as "catuaba", shows several biological activities and has emerged as a potential source of new drugs. Considering that more than 10 species are known under the same popular name, regulatory agencies require more rigorous quality control of this medicinal plant. OBJECTIVE: To develop and validate a methodology using capillary electrophoresis (CE) with ultraviolet (UV) detection for analysing polyphenols in the ethyl-acetate fraction (EAF) of Trichilia catigua...
December 2, 2016: Phytochemical Analysis: PCA
https://www.readbyqxmd.com/read/27908629/evaluation-of-the-cytotoxicity-genotoxicity-and-mucus-permeation-capacity-of-several-surface-modified-poly-anhydride-nanoparticles-designed-for-oral-drug-delivery
#5
T Iglesias, A López de Cerain, Juan Manuel Irache, N Martín-Arbella, M Wilcox, J Pearson, A Azqueta
The main concerns with drugs designed for oral administration are their inactivation or degradation in the harsh conditions of the gastrointestinal tract, their poor solubility through the gastrointestinal mucus gel layer, the poor intestinal epithelium permeability that limits their absorption, and their toxicity. In this context, poly(anhydride) nanoparticles are capable of protecting the drug from the harsh environment, reduce the drug's toxicity and, by virtue of surface modification, to enhance or reduce their mucus permeability and the bioadhesion to specific target cells...
November 28, 2016: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/27908496/mixed-mode-acrylamide-based-continuous-beds-bearing-tert-butyl-groups-for-capillary-electrochromatography-synthesized-via-complexation-of-n-tert-butylacrylamide-with-a-water-soluble-cyclodextrin-part-i-retention-properties
#6
Ayat Allah Al-Massaedh, Ute Pyell
With the aim to improve the understanding of morphology and efficiency properties, we investigate in this series the impact of the complex formation constant of the hydrophobic monomer with respect to statistically methylated-β-cyclodextrin (Me-β-CD) on the electrochromatographic properties of highly crosslinked amphiphilic mixed-mode acrylamide-based monolithic stationary phases. Based on our previous work on amphiphilic mixed-mode monolithic stationary phases for capillary electrochromatography (CEC) using N-(1-adamantyl)acrylamide (Ad-AAm) as hydrophobic monomer that forms an extremely strong water-soluble inclusion complex with Me-β-CD, we now selected N-tert-butylacrylamide (NTBA) as hydrophobic monomer forming an inclusion complex with Me-β-CD with a much lower value of the formation constant...
November 21, 2016: Journal of Chromatography. A
https://www.readbyqxmd.com/read/27907988/kr12-peptide-associated-with-cyclodextrin-antimicrobial-and-antitumor-activities
#7
Karina I R Teixeira, Maria E Cortés, Robson A S Santos, Flávio Oliveira, Ruben D Sinisterra
The aim of this study was to determine the physical properties and antimicrobial and antiproliferative effects of the KR12 peptide complexed with 2-hydroxypropyl-β-cyclodextrin (Hp-βCd) in vitro. The KR12:Hp-βCd composition was evaluated for particle size and its zeta (ζ)-potential in the presence and absence of cells. Antimicrobial activity against Streptococcus mutans, Actinobacillus actinomycetemcomitans, and Porphyromonas gingivalis for the peptide alone or associated was evaluated by minimal inhibitory concentration...
December 1, 2016: Biointerphases
https://www.readbyqxmd.com/read/27903454/effects-of-frequently-used-pharmaceutical-excipients-on-the-organic-cation-transporters-1-3-and-peptide-transporters-1-2-stably-expressed-in-mdckii-cells
#8
Marcus Otter, Stefan Oswald, Werner Siegmund, Markus Keiser
There is ample evidence that pharmaceutical excipients, which are supposed to be pharmacologically inactive, have an impact on drug metabolism and efflux transport. So far, little is known whether they also modulate uptake transporter proteins. We have recently shown that commonly used solubilizing agents exert significant effects on the function of organic anion uptake transporting polypeptides. Therefore, we investigated in this study the influence of frequently used pharmaceutical excipients on the transport activity of organic cation transporters OCT1, OCT2 and OCT3 and the peptide transporters PEPT1 and PEPT2...
November 26, 2016: European Journal of Pharmaceutics and Biopharmaceutics
https://www.readbyqxmd.com/read/27897389/new-insights-into-the-difference-between-rotaxane-and-pseudorotaxane
#9
He-Lue Sun, Heng-Yi Zhang, Zhen Dai, Xu Han, Yu Liu
Rotaxane and pseudorotaxane are two sorts of different mechanically interlocked molecular architectures, and there is obvious topological difference and boundary between them. In this work, a "suggested [2]rotaxane 1α-CD" was constructed based on an axle molecule 1 bearing two terminal ferrocene groups and a wheel component α-cyclodextrin (α-CD), but the result obtained indicated that the ferrocene group cannot prevent α-CD dethreading under UV irradiation. That is, 1α-CD is just a pseudo[2]rotaxane...
November 29, 2016: Chemistry, An Asian Journal
https://www.readbyqxmd.com/read/27896590/improvement-in-thermal-stability-of-sucralose-by-%C3%AE-cyclodextrin-metal-organic-frameworks
#10
Nana Lv, Tao Guo, Botao Liu, Caifen Wang, Vikaramjeet Singh, Xiaonan Xu, Xue Li, Dawei Chen, Ruxandra Gref, Jiwen Zhang
PURPOSE: To explain thermal stability enhancement of an organic compound, sucralose, with cyclodextrin based metal organic frameworks. METHODS: Micron and nanometer sized basic CD-MOFs were successfully synthesized by a modified vapor diffusion method and further neutralized with glacial acetic acid. Sucralose was loaded into CD-MOFs by incubating CD-MOFs with sucralose ethanol solutions. Thermal stabilities of sucralose-loaded basic CD-MOFs and neutralized CD-MOFs were investigated using thermogravimetric analysis (TGA), differential scanning calorimetry (DSC) and high performance liquid chromatography with evaporative light-scattering detection (HPLC-ELSD)...
November 28, 2016: Pharmaceutical Research
https://www.readbyqxmd.com/read/27888567/chiral-separation-of-benzothiazole-derivatives-of-amino-acids-using-capillary-zone-electrophoresis
#11
Zuzana Nováková, Vladimír Pejchal, Jan Fischer, Petr Česla
A method for the separation of enantiomers of leucine and phenylalanine benzothiazole derivatives as potential antimicrobial agents was developed using capillary zone electrophoresis with a dual cyclodextrin system. The best resolution of enantiomers was achieved in 100 mmol.L(-1) phosphate background electrolyte pH 3.5 with dual cyclodextrin system consisting of 10 mmol.L(-1) of β-cyclodextrin with 10 mmol.L(-1) of 2-hydroxypropyl-β-cyclodextrin for leucine derivative and 10 mmol.L(-1) of 2-hydroxypropyl-γ-cyclodextrin for phenylalanine derivative, respectively...
November 26, 2016: Journal of Separation Science
https://www.readbyqxmd.com/read/27886300/a-three-dimensional-graphene-oxide-supramolecular-hydrogel-for-infrared-light-responsive-cascade-release-of-two-anticancer-drugs
#12
Wei Ha, Xiao-Bo Zhao, Kan Jiang, Yang Kang, Juan Chen, Bang-Jing Li, Yan-Ping Shi
A three dimensional supramolecular hydrogel consisting of prodrug-modified graphene oxide and α-cyclodextrin was developed. This hydrogel with a well-ordered interior microstructure integrated hydrophobic and hydrophilic anticancer drugs into a single multifunctional platform, and underwent a gel-sol transition leading to cascade release of two drugs in an on-demand fashion upon NIR light irradiation.
November 25, 2016: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/27886123/one-pot-click-access-to-a-cyclodextrin-dimer-based-novel-aggregation-induced-emission-sensor-and-monomer-based-chiral-stationary-phase
#13
Xiaoli Li, Rui Zhao, Xiaoying Tang, Yanyan Shi, Chunyi Li, Yong Wang
A 'two birds, one stone' strategy was developed via a one-pot click reaction to simultaneously prepare a novel cyclodextrin (CD) dimer based aggregation induced emission (AIE) sensor (AIE-DCD) and a monomer based chiral stationary phase (CSP-MCD) for chiral high performance liquid chromatography (CHPLC). AIE-DCD was found to afford satisfactory AIE response for specific detection of Zn(2+) with a detection limit of 50 nM. CSP-MCD exhibits excellent enantioseparation ability toward dansyl amino acids, where the resolution of dansyl amino leucine reaches 5...
November 24, 2016: Sensors
https://www.readbyqxmd.com/read/27884808/biodegradable-nano-polymers-as-delivery-vehicles-for-therapeutic-small-non-coding-ribonucleic-acids
#14
REVIEW
Ahad Mokhtarzadeh, Abbas Alibakhshi, Maryam Hashemi, Maryam Hejazi, Vahedeh Hosseini, Miguel de la Guardia, Mohammad Ramezani
Nowadays, small non-coding Ribo Nucleic Acids (sncRNAs) such as siRNA, miRNA and shRNA are extremely serving to gene regulation. They are involved in many biological processes and in an increasing number of studies regarding a variety of application of sncRNAs toward human health and relieving diseases ranging from metabolic disorders to those involving various organ systems as well as different types of cancer. One of the most severe limitations for applying RNA interference technology is the absence of safe and effective carriers for in vivo delivery, including localizing the molecules to a specific site of interest and sustaining the presentation of the payloads for a controlled period of time...
November 21, 2016: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/27878682/dft-study-on-the-effects-of-%C3%AE-cyclodextrin-in-synthesis-of-2-phenylbenzimidazole-via-benzaldehyde-and-o-phenylenediamine
#15
Yamei Cheng, Xueye Wang, Weiwei Li, Dan Chang
The conversion of 2-phenylbenzimidazole using o-phenylenediamine and benzaldehyde can be improved significantly under β-cyclodextrin (β-CD). The density functional theory (DFT) method was applied to study the whole process. According to energy parameters (binding energy, deformation energy) and structural deformation, entry models and the reaction process can be pinpointed, with o-phenylenediamine embedding β-CD from a wide rim, and then benzaldehyde passing into the inclusion from the narrow rim. Subsequently, natural bonding orbital (NBO), Mulliken charge, frontier orbital, FuKui function and nuclear magnetic resonance (NMR) methods were employed to reveal the mechanism of electron transfer...
December 2016: Journal of Molecular Modeling
https://www.readbyqxmd.com/read/27878148/photo-chemo-dual-controlled-reversible-morphological-conversion-and-chiral-modulation-of-supramolecular-nanohelixes-with-nanosquares-and-nanofibers
#16
Wen Zhang, Yong Chen, Jie Yu, Xu-Jie Zhang, Yu Liu
A photo/chemo dually interconvertible system was constructed through the supramolecular assembly of azobenzene-diphenylalanine (Azo-FF) with α-cyclodextrin. The resultant chiral nanohelix was able to interconvert into a nanosquare upon irradiation at different wavelengths, but into a nanofiber upon changing solvent polarity, which provides a feasible way to achieve highly ordered nanostructures with various morphologies, dimensions and chiralities.
November 23, 2016: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/27877888/lysosomal-ph-inducible-supramolecular-dissociation-of-polyrotaxanes-possessing-acid-labile-n-triphenylmethyl-end-groups-and-their-therapeutic-potential-for-niemann-pick-type-c-disease
#17
Atsushi Tamura, Kei Nishida, Nobuhiko Yui
Niemann-Pick type C (NPC) disease is characterized by the accumulation of cholesterol in lysosomes. We have previously reported that biocleavable polyrotaxanes (PRXs) composed of β-cyclodextrins (β-CDs) threaded onto a linear polymer capped with bulky stopper molecules via intracellularly cleavable linkers show remarkable cholesterol reducing effects in NPC disease patient-derived fibroblasts owing to the stimuli-responsive intracellular dissociation of PRXs and subsequent β-CD release from the PRXs. Herein, we describe a series of novel acid-labile 2-(2-hydroxyethoxy)ethyl group-modified PRXs (HEE-PRXs) bearing terminal N-triphenylmethyl (N-Trt) groups as a cleavable component for the treatment of NPC disease...
2016: Science and Technology of Advanced Materials
https://www.readbyqxmd.com/read/27875913/development-and-optimization-of-a-meloxicam-%C3%AE-cyclodextrin-complex-for-orally-disintegrating-tablet-using-statistical-analysis
#18
Ahmad Ainurofiq, Syaiful Choiri
The purpose of this research was to develop an inclusion complex of meloxicam (MEL)/β-cyclodextrin (β-CD) incorporated into an orally disintegrating tablet (ODT), using statistical analysis to optimize the ODT formulation based on a quality by design (QbD) approach. MEL/β-CD complexation was performed by kneading, co-precipitation, and spray drying methods under different molar ratios. Fourier transform infrared spectroscopy, X-Ray diffraction, and thermal analysis were utilized to evaluate the complexes...
November 22, 2016: Pharmaceutical Development and Technology
https://www.readbyqxmd.com/read/27874116/understanding-carbohydrate-protein-interactions-using-homologous-supramolecular-chiral-ru-ii-glyconanoclusters
#19
Harikrishna Bavireddi, Raghavendra Vasudeva Murthy, Madhuri Gade, Sivakoti Sangabathuni, Preeti Madhukar Chaudhary, Catherine Alex, Bernd Lepenies, Raghavendra Kikkeri
Multivalent glycodendrimers make promising tools to tackle the basic and translational research in the field of carbohydrate-mediated interactions. Despite advances in glycodendrimers and glycopolymers, the multivalent probes available to date are still far from being ideal biological mimics. This work demonstrates the inherent chirality of glycodendrimers to be one of the promising factors to generate different spatial carbohydrate micro-environments to modulate specific carbohydrate-protein interactions. By exploiting the host-guest strategy, chiral Ru(ii) complexes (Δ and Λ) and mannose capped β-cyclodextrin (β-CD), we generated a library of homologous metallo-glycodendrimers (MGDs) with sizes of 50-70 nm...
December 1, 2016: Nanoscale
https://www.readbyqxmd.com/read/27872310/efficient-replacement-of-plasma-membrane-outer-leaflet-phospholipids-and-sphingolipids-in-cells-with-exogenous-lipids
#20
Guangtao Li, JiHyun Kim, Zhen Huang, Johnna R St Clair, Deborah A Brown, Erwin London
Our understanding of membranes and membrane lipid function has lagged far behind that of nucleic acids and proteins, largely because it is difficult to manipulate cellular membrane lipid composition. To help solve this problem, we show that methyl-α-cyclodextrin (MαCD)-catalyzed lipid exchange can be used to maximally replace the sphingolipids and phospholipids in the outer leaflet of the plasma membrane of living mammalian cells with exogenous lipids, including unnatural lipids. In addition, lipid exchange experiments revealed that 70-80% of cell sphingomyelin resided in the plasma membrane outer leaflet; the asymmetry of metabolically active cells was similar to that previously defined for erythrocytes, as judged by outer leaflet lipid composition; and plasma membrane outer leaflet phosphatidylcholine had a significantly lower level of unsaturation than phosphatidylcholine in the remainder of the cell...
November 21, 2016: Proceedings of the National Academy of Sciences of the United States of America
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