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Cyclodextrin

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https://www.readbyqxmd.com/read/29471224/quantification-of-desoxyrhapontigenin-4-methoxyresveratrol-in-rat-plasma-by-lc-ms-ms-application-to-pre-clinical-pharmacokinetic-study
#1
Yu Dai, Amanda Li Cheng Tan, Huan Chen, Pei Shi Ong, Xiaoqiang Xiang, Jinzhu Wu, Hai-Shu Lin
Desoxyrhapontigenin (DRG, 4-methoxyresveratrol or trans-3,5-dihydroxy-4'-methoxystilbene) is a naturally occurring resveratrol (RES) derivative with a variety of biological activities. To facilitate its further medicinal exploration, a reliable LC-MS/MS method was developed and validated for the quantification of DRG in rat plasma using heavy isotope labelled RES as an internal standard. The ESI was operated in its negative ion mode while DRG and RES were determined by multiple reaction monitoring (MRM) using precursor-to-product ion transitions of m/z 241...
February 13, 2018: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/29469921/enhanced-chiral-recognition-by-%C3%AE-cyclodextrin-cucurbit-6-uril-cowheeled-4-pseudorotaxanes
#2
Ling Dai, Wanhua Wu, Wenting Liang, Wentong Chen, Xingke Yu, Jiecheng Ji, Chao Xiao, Cheng Yang
Mixing γ-cyclodextrin (γ-CD), cucurbit[6]uril (CB[6]) and tetraammonium-bearing axles together led to a spontaneous formation of γ-CD-CB[6]-cowheeled [4]pseudorotaxanes. The well-defined unsymmetrical cavities thus formed enhance the binding affinity towards chiral amines by factors of several hundreds and show remarkably improved chiral discrimination.
February 22, 2018: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/29468823/molecularly-selective-regulation-of-delivery-fluxes-employing-supramolecular-bindings-in-layer-by-layer-films
#3
Tao Huang, Xinglong Luan, Qi Xia, Shaofeng Pan, Qi An, Yaling Wu, Yihe Zhang
The molecularly selective regulation of molecular fluxes in a biomaterial that delivers simultaneously multiple chemical species is still beyond the touch of materials scientists. We developed a delivery material using layer-by-layer (LbL) technique that discriminatively regulates the delivery flux of bioactive small molecules, represented by a peptide containing RGD fragment and the chemotherapy drug DOX. Molecularly selective flux regulations in layer-by-layer films are realized using fast reversible supramolecular bindings between cyclodextrin and its guests...
February 22, 2018: Chemistry, An Asian Journal
https://www.readbyqxmd.com/read/29467593/depletion-of-membrane-cholesterol-compromised-caspase-8-imparts-in-autophagy-induction-and-inhibition-of-cell-migration-in-cancer-cells
#4
Mukesh Kumar, Karuna Irungbam, Meena Kataria
Background: Cholesterol in lipid raft plays crucial role on cancer cell survival during metastasis of cancer cells. Cancer cells are reported to enrich cholesterol in lipid raft which make them more susceptible to cell death after cholesterol depletion than normal cells. Methyl-β-cyclodextrin (MβCD), an amphipathic polysaccharide known to deplete the membrane cholesterol, induces cell death selectively in cancer cells. Present work was designed to identify the major form of programmed cell death in membrane cholesterol depleted cancer cells (MDA-MB 231 and 4T1) and its impact on migration efficiency of cancer cells...
2018: Cancer Cell International
https://www.readbyqxmd.com/read/29458042/pretreatment-with-cholesterol-loaded-cyclodextrins-prevents-loss-of-motility-associated-proteins-during-cryopreservation-of-addra-gazelle-nanger-dama-ruficollis-spermatozoa
#5
Jessye Wojtusik, Yan Wang, Budhan S Pukazhenthi
Sperm cryopreservation is challenging, often resulting in irreversible damage to spermatozoa, as indicated by decreased motility, viability, and/or acrosomal integrity. Developing cryopreservation protocols for gametes of endangered species compounds the complexity of technique optimization; samples are difficult to obtain and numbers are limited. Cryopreservation of sperm collected from the critically endangered addra gazelle (Nanger dama ruficollis), a member of the Bovidae family, resulted in significant loss of motility, which was prevented by pretreatment with cholesterol-loaded cyclodextrin (CLC)...
February 16, 2018: Cryobiology
https://www.readbyqxmd.com/read/29455985/pd-hnts-cdns-g-c-3-n-4-a-novel-heterogeneous-catalyst-for-promoting-ligand-and-copper-free-sonogashira-and-heck-coupling-reactions-benefits-from-halloysite-and-cyclodextrin-chemistry-and-g-c-3-n-4-contribution-to-suppress-pd-leaching
#6
Samahe Sadjadi, Majid M Heravi, Masoumeh Malmir
For the first time, a ternary hybrid system composed of halloysite nanotubes, HNTs, cyclodextrin nanosponges, CDNS, and g-C3 N4 is prepared and used for immobilization of Pd(0) nanoparticles and development of a heterogeneous catalyst, Pd@HNTs-CDNS-g-C3 N4 for promoting ligand and copper-free Sonogashira and Heck coupling reactions in aqueous media. HNT as a porous tubular clay with outstanding thermal, mechanical and textural properties can act as a support for immobilizing Pd nanoparticles. The role of CDNS can be explained on the base of its capability to form inclusion complexe with substrates and bringing them in the vicinity of the catalytic active sites...
April 15, 2018: Carbohydrate Polymers
https://www.readbyqxmd.com/read/29455521/self-assembly-of-binuclear-cu-ii-histidine-complex-for-absolute-configuration-and-enantiomeric-excess-determination-of-naproxen-by-tandem-mass-spectrometry
#7
Xiangying Yu, Man-Chu Chau, Wai Kit Tang, Chi-Kit Siu, Zhong-Ping Yao
Naproxen is one of the most consumed non-steroidal anti-inflammatory drugs and marketed as S-naproxen since R-naproxen is hepatotoxic. In this study, chiral recognition of naproxen has been investigated by tandem mass spectrometry (MS/MS). Among all diastereomeric complexes formed between naproxen and the examined chiral selectors, including cyclodextrins (α/β/γ-CD), modified phenylalanines (N-acetyl-phenylalanine, N-t-butoxycarbonyl-phenylalanine, N-9-fluorenylmethyloxycarbonyl-phenylalanine), amino acids (Trp, Phe, Tyr, His), glucose, tartaric acid and vancomycin, a novel binuclear metal bound diastereomeric complexes [(M(II))2 (S/R-Naproxen)(L-His)2 -3H]+ (M = Cu, Ni or Co with Cu being the best) could allow effective identification of the absolute configuration of naproxen and determination of its enantiomeric excess (ee) through MS/MS analysis...
February 17, 2018: Analytical Chemistry
https://www.readbyqxmd.com/read/29454617/antihypertensive-potential-of-linalool-and-linalool-complexed-with-%C3%AE-cyclodextrin-effects-of-subchronic-treatment-on-blood-pressure-and-vascular-reactivity
#8
Samuel Barbosa Camargo, Letícia Oliveira Simões, Carla Fiama de Azevedo Medeiros, Anderson de Melo Jesus, Josmara Bartolomei Fregoneze, Afrânio Evangelista, Cristiane Flora Villarreal, Adriano Antunes de Souza Araújo, Lucindo José Quintans-Júnior, Darizy Flavia Silva
Linalool (LIN) is a monoterpene alcohol present in some aromatic medicinal plants with biological activities that can impact cardiovascular diseases. This chemical class is highly volatile and β-cyclodextrin (β-CD) has been employed to improve the pharmacological properties of monoterpenes. Thus, the aim of this study was to evaluate the cardiovascular effects of LIN free focusing on the antihypertensive properties of this monoterpene and to study whether LIN, complexed in β-cyclodextrin (LIN-βCD) is able to improve the pharmacological activity of LIN...
February 15, 2018: Biochemical Pharmacology
https://www.readbyqxmd.com/read/29454166/a-water-based-topical-chinese-traditional-medicine-zicao-for-wound-healing-developed-using-2-hydroxypropyl-%C3%AE-cyclodextrin
#9
Ta Chen Chen, Song-Cu Yu, Chin-Mu Hsu, Fuu-Jen Tsai, Yuhsin Tsai
Zicao is a traditional Chinese herbal medicine that has been used for the topical treatment of wounds in the form of oil-based ointment for several hundred years. To overcome the disadvantages of oil-based ointment such as irritation, discomfort, and difficulty in cleaning, this study developed a water-based topical formulation of Zicao. An ethanol extract of Zicao was included in 2-hydroxypropyl-β-cyclodextrin (HP-β-CD) to form a water-soluble Zicao-HP-β-CD complex. The formation of the Zicao-HP-β-CD complex was determined using LC-MS, 1 H NMR, ROSEY, and solubility analysis...
February 10, 2018: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/29453052/ac-lvffark-nh-2-conjugation-to-%C3%AE-cyclodextrin-exhibits-significantly-enhanced-performance-on-inhibiting-amyloid-%C3%AE-protein-fibrillogenesis-and-cytotoxicity
#10
Huan Zhang, Xiaoyan Dong, Fufeng Liu, Jie Zheng, Yan Sun
Inhibition of amyloid β-protein (Aβ) aggregation is of significance for the potential treatment of Alzheimer's disease. We have herein conjugated heptapeptide Ac-LVFFARK-NH 2 (LK7) to β-cyclodextrin (βCyD) and studied the inhibitory effect of the LK7-βCyD conjugate on Aβ aggregation. The conjugation significantly improved the peptide solubility and suppressed the self-assembly propensity. This led to 30% increase of the binding affinity of LK7 for Aβ in the conjugate due to increased hydrophobic interactions...
February 11, 2018: Biophysical Chemistry
https://www.readbyqxmd.com/read/29452945/reduction-sensitive-fluorescence-enhanced-polymeric-prodrug-nanoparticles-for-combinational-photothermal-chemotherapy
#11
Yuanyuan Zhang, Dan Yang, Hongzhong Chen, Wei Qi Lim, Fiona Soo Zeng Phua, Guanghui An, Piaoping Yang, Yanli Zhao
In this study, a reduction-sensitive supramolecular polymeric drug delivery system was developed for combinational photothermal-chemotherapy of cancer. The multifunctional system was self-assembled by specific host-guest interactions between hydrophilic β-cyclodextrin functionalized hyaluronic acid and adamantane linked camptothecin/dye conjugate, where a near-infrared (NIR) absorbing dye IR825 was loaded. The hydrophilic hyaluronic acid shell endows the assembly with excellent colloidal stability and biocompatibility...
February 9, 2018: Biomaterials
https://www.readbyqxmd.com/read/29452493/in-vitro-and-in-vivo-evaluation-of-cyclodextrin-based-nanosponges-for-enhancing-oral-bioavailability-of-atorvastatin-calcium
#12
Mohamed F Zidan, Hany M Ibrahim, Mohsen I Afouna, Elsherbeny A Ibrahim
The aim of this study was to explore the feasibility of complexing the poorly water-soluble drug atorvastatin calcium (AC) with β-cyclodextrin (β-CD) based nanosponges (NS), which offer advantages of improving dissolution rate and eventually oral bioavailability. Blank NS were fabricated at first by reacting β-CD with the cross-linker carbonyldiimidazole at different molar ratios (1:2, 1:4 and 1:8), then NS of highest solubilization extent for AC were complexed with AC. AC loaded NS (AC-NS) were characterized for various physicochemical properties...
February 16, 2018: Drug Development and Industrial Pharmacy
https://www.readbyqxmd.com/read/29452113/technological-innovation-strategies-for-the-specific-treatment-of-chagas-disease-based-on-benznidazole
#13
REVIEW
Leslie Raphael de Moura Ferraz, Alinne Élida Gonçalves Alves, Débora Dolores Souza da Silva Nascimento, Isabela Araújo E Amariz, Aline Silva Ferreira, Salvana Priscylla Manso Costa, Larissa Araújo Rolim, Ádley Antonini Neves de Lima, Pedro José Rolim Neto
Caused by Trypanosoma cruzi, Chagas disease is responsible for public health problems greater in magnitude than those attributed to malaria, schistosomiasis, or leishmaniasis. A factor in the socioeconomic development of poor countries, Chagas disease can cause death due to a high parasitic burden during its acute phase due and irreversible damage in organs such as the heart, esophagus, and colon during its chronic phase, even when the number of parasites is minimal. For treating Chagas disease, benznidazole (BNZ) remains the drug of choice and, in Latin America, the only drug on the market for treating the disease...
February 13, 2018: Acta Tropica
https://www.readbyqxmd.com/read/29451297/enhancement-of-the-conductivity-detection-signal-in-capillary-electrophoresis-systems-using-neutral-cyclodextrins-as-sweeping-agents
#14
Milan Boublík, Martina Riesová, Pavel Dubský, Bohuslav Gaš
Conductivity detection is a universal detection technique often encountered in electrophoretic separation systems, especially in modern chip-electrophoresis based devices. On the other hand, it is sparsely combined with another contemporary trend of enhancing limits of detection by means of various preconcentration strategies. This can be attributed to the fact that a preconcentration experimental setup usually brings about disturbances in a conductivity baseline. Sweeping with a neutral sweeping agent seems a good candidate for overcoming this problem...
February 16, 2018: Electrophoresis
https://www.readbyqxmd.com/read/29450829/artificial-lipid-membrane-permeability-method-for-predicting-intestinal-drug-transport-probing-the-determining-step-in-the-oral-absorption-of-sulfadiazine-influence-of-the-formation-of-binary-and-ternary-complexes-with-cyclodextrins
#15
Alicia Delrivo, Carolina Aloisio, Marcela R Longhi, Gladys Granero
We propose an in vitro permeability assay by using a modified lipid membrane to predict the in vivo intestinal passive permeability of drugs. Two conditions were tested, one with a gradient pH (pH 5.5 donor/pH 7.4 receptor) and the other with an iso-pH 7.4. The predictability of the method was established by correlating the obtained apparent intestinal permeability coefficients (P app ) and the oral dose fraction absorbed in humans (f a ) of 16 drugs with different absorption properties. The P app values correlated well with the absorption rates under the two conditions, and the method showed high predictability and good reproducibility...
February 15, 2018: AAPS PharmSciTech
https://www.readbyqxmd.com/read/29448513/removing-control-of-cyclodextrin-drug-complexes-using-high-affinity-molecule
#16
Young-Hwan Kim, Sung Tae Kim, Jun-Pil Jee, Dae-Young Kim, Dongjin Kang, Kyeongsoon Kim, Sang Yeob Park, Taeyong Sim, Kwan Hyung Cho, Dong-Jin Jang
Nanostructured supramolecular assemblies with hydrophobic cavities are used for improving the solubility, bioavailability, and stability of poorly water soluble drugs. In particular, host-guest inclusion using 2-hydroxypropyl-beta-cyclodextrin (HP-β-CD) is a typical approach in the pharmaceutical field. In this study, celecoxib (CXB), a cyclooxygenase-2 selective nonsteroidal anti-inflammatory drug (NSAID), was used as the model drug (guest material) and effectively incorporated into HP-β-CD (host material)...
February 1, 2018: Journal of Nanoscience and Nanotechnology
https://www.readbyqxmd.com/read/29446623/photo-controlled-coumarin-diphenylalanine-cyclodextrin-cross-linking-of-1d-nanofibers-to-2d-thin-films
#17
Ni Cheng, Yong Chen, Jie Yu, Jing-Jing Li, Yu Liu
Using coumarin-modified diphenylalanine (CO-FF) and gamma-cyclodextrin (gamma-CD) as building blocks, one-dimensional nanofibers with several nanometers in width and tens of micrometers in length were successfully constructed. Through the photo-dimerization of coumarin units in CO-FF/gamma-CD complexes, the resultant nanofibers could cross-linked to organic 2D thin films with a lateral dimension of tens of micrometers and a thickness of nanometers. The resultant thin films exhibited a sig-nificant fluorescence enhancement for twisted intramolecular charge-transfer (TICT) molecules and effective removal of pollut-ant from water through filtration...
February 15, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29446622/hyper-crosslinked-porous-mos2-cyclodextrin-polymer-frameworks-rapid-and-durable-removal-of-aromatic-phenolic-micropollutant-from-water
#18
Jian Liu, Yanmei Yang, Jinwei Bai, Huang Wen, Fengjuan Chen, Baodui Wang
A reasonable and efficient strategy for the construction of hyper-crosslinked porous MoS2-CD-polymer frameworks (MoS2CDPFs) was demonstrated. Here, MoS2 nanosheets (NSs) can be decorated with amino functionalized β-Cyclodextrin, giving rise to a nanoscale structural motif (MoS2@CD) for the synthesis of MoS2CDPFs. We demonstrated that CD polymer (CDP) can be acted as linker and uniformly incorporated into the frameworks. In addition to the pores created between MoS2 NSs, polymer doping generates extra interspace between MoS2 NSs and CD monomer...
February 15, 2018: Analytical Chemistry
https://www.readbyqxmd.com/read/29442976/crosslinked-dextran-gel-microspheres-with-computed-tomography-angiography-and-drug-release-function
#19
Changhao Zhu, Xiaoe Ma, Dandan Ma, Tianzhu Zhang, Ning Gu
For computed tomography (CT) angiography and drug release application, a kind of novel dextran hydrogel microspheres were prepared. β-cyclodextrin (β-CD) grafted poly(methyl vinyl ether-altmaleic acid) (PMVE-alt-MA-g-β-CD) and succinic acid modified dextran (Dex-SA) were first prepared, and then PMVE-alt-MA-g-β-CD was further used as the cross-linking agent to cross link Dex-SA for the formation of dextran hydrogel microspheres by using an inverse suspension polymerization method for the potential interventional embolization...
April 1, 2018: Journal of Nanoscience and Nanotechnology
https://www.readbyqxmd.com/read/29442144/quantitative-structure-retention-relationship-modeling-of-selected-antipsychotics-and-their-impurities-in-green-liquid-chromatography-using-cyclodextrin-mobile-phases
#20
Nevena Maljurić, Jelena Golubović, Biljana Otašević, Mira Zečević, Ana Protić
Applying green chromatography methods is currently one of the challenges in liquid chromatography. Among different strategies, using cyclodextrin (CD) mobile phase modifiers was applied in this paper. CDs can form inclusion complexes with a wide variety of hydrophobic organic compounds and, consequently, affect their retention behavior. CD-containing mobile phases possess complicated complexation and adsorption equilibria so retention is dependent not only on chromatographic parameters and properties of the compound but also on properties of compound-CD complex...
February 13, 2018: Analytical and Bioanalytical Chemistry
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