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Xueyan Li, Xianwen Kan
In this study, a ratiometric strategy-based electrochemical sensor was developed by electropolymerization of thionine (THI) and β-cyclodextrin (β-CD) composite films on a glassy carbon electrode surface for imidacloprid (IMI) detection. THI played the role of an inner reference element to provide a built-in correction. In addition, the modified β-CD showed good selective enrichment for IMI to improve the sensitivity and anti-interference ability of the sensor. The current ratio between IMI and THI was calculated as the detected signal for IMI sensing...
April 18, 2018: Analyst
Henriette S Frislev, Janni Nielsen, Jesper Nylandsted, Daniel Otzen
Cholesterol (chol) is important in all mammalian cells as a modulator of membrane fluidity. However, its low solubility is a challenge for controlled delivery to membranes. Here we introduce a new tool to deliver chol to membranes, namely, liprotides, i.e., protein-lipid complexes composed of a fatty acid core decorated with partially denatured protein. We focus on liprotides prepared by incubating Ca2+ -depleted α-lactalbumin with oleic acid (OA) for 1 h at 20 °C (lip20) or 80 °C (lip80). The binding and membrane delivery properties of liprotides is compared to the widely chol transporter methyl-β-cyclodextrin (mBCD)...
April 17, 2018: Journal of Membrane Biology
Margherita De Rosa, Pellegrino La Manna, Carmen Talotta, Annunziata Soriente, Carmine Gaeta, Placido Neri
In the last decades many efforts have been devoted to design supramolecular organocatalysts able to work in water as the reaction medium. The use of water as solvent provides promising benefits with respect to environmental impact. In this context, macrocyclic compounds played a role of primary importance thanks to their ease of synthesis and their molecular recognition abilities toward the reactants. The aim of this review is to give an overview of the recent advances in the field of supramolecular organocatalysis in water, focusing the attention on calixarene and cyclodextrins derivatives...
2018: Frontiers in Chemistry
Sara E Bianchi, Barbara E K Machado, Marília G C da Silva, Michelle M A da Silva, Lidiane Dal Bosco, Magno S Marques, Ana P Horn, Lara Persich, Fabiana C Geller, Débora Argenta, Helder F Teixeira, Cláudia M O Simões, Cristiana L Dora, Valquíria L Bassani
Several beneficial effects on the skin have been reported for coumestrol (COU), such as protection against photoaging and improvement of skin elasticity and thickness in postmenopausal women. However no reports on the effect of COU on wound healing were found. Nevertheless, COU has low aqueous solubility, which is a crucial limitation for biological tests. The present study was designed as a two-step experiment to evaluate the wound healing effect of COU. First, we used fibroblasts and the experimental in vitro artificial wound model, scratch assay, to compare the effects of COU free, dissolved in dimethyl sulfoxide (DMSO) or Dulbecco's modified Eagle's medium (DMEM), or associated with hydroxypropyl-β-cyclodextrin (HPβCD)...
April 14, 2018: European Journal of Pharmaceutical Sciences
Hui Zhang, Xujun Qiu, Liqiong Lv, Wenyu Sun, Chaoyue Wang, Jizhong Yan, Shengqiang Tong
Recycling countercurrent chromatography was successfully applied to resolution of 2-(4-bromomethylphenyl)propionic acid, a key synthetic intermediate for synthesis of nonsteroidal anti-inflammatory drug loxoprofen, using hydroxypropyl-β-cyclodextrin as chiral selector. The two-phase solvent system composed of n-hexane/n-butyl acetate/0.1 mol L-1 citrate buffer solution with pH = 2.4 (8:2:10, v/v/v) was selected. Influence factors for the enantioseparation were optimized, including type of substituted β-cyclodextrin, concentration of hydroxypropyl-β-cyclodextrin, separation temperature and pH of aqueous phase...
April 17, 2018: Journal of Separation Science
Aurélia Malapert, Valerie Tomao, Olivier Dangles, Emmanuelle Reboul
Hydroxytyrosol bioaccessibility and absorption by the intestinal cells have been studied using an in vitro digestion model and Caco-2 TC7 monolayers cells in culture, in the presence or absence of β-cyclodextrin and foods. Hydroxytyrosol was either provided as a pure standard or in an alperujo powder. The presence of foods significantly decreased hydroxytyrosol bioaccessibility and absorption (-20% and -10%, respectively), while β-cyclodextrin had no effect. Moreover, the presence of other compounds from alperujo in the intestine compartment reduced hydroxytyrosol absorption by Caco-2 cells compared to pure standard (-60%)...
April 17, 2018: Journal of Agricultural and Food Chemistry
Douglas M Bennion, Chad H Jones, Lauren L Donnangelo, Justin T Graham, Jacob D Isenberg, Alex N Dang, Vermali Rodriguez, Ruben D M Sinisterra, Frederico B Sousa, Robson A S Santos, Colin Sumners
NEW FINDINGS: What is the central question of this study? Angiotensin-(1-7) decreases cerebral infarct volume and improves neurological function when delivered centrally prior to and during ischemic stroke. Here, we assessed the neuroprotective effects of angiotensin-(1-7) when delivered orally post-stroke. What is the main finding and its importance? We show that oral delivery of angiotensin-(1-7) attenuates cerebral damage induced by middle cerebral artery occlusion in rats, without affecting blood pressure or cerebral blood flow...
April 16, 2018: Experimental Physiology
Mengbi Wei, Xianhai Yang, Peter Watson, Feifei Yang, Huihui Liu
Solubility is a crucial limiting factor in pharmaceutical research and contaminated site remediation. Cyclodextrin, with its structure of hydrophilic exterior and hydrophobic cavity, has a potential ability to enhance the hydrophobic chemical's solubility through the formation of host-guest complex. The stability of host-guest complex is often quantified by the inclusion constant. In this study, the logarithm of 1:1 α-cyclodextrin inclusion constants (log K α ) for 195 organic chemicals was collected. With this parameter as the endpoint, a quantitative structure-activity relationship (QSAR) model was developed using DRAGON descriptors and stepwise multiple linear regression analysis...
April 17, 2018: Environmental Science and Pollution Research International
Aafrin M Pettiwala, Prabhat K Singh
Discriminating proteins using simple methods is a highly ambitious task. Herein, we provide the first report of a cyclodextrin based supramolecular host-guest assembly, which without involving any specially designed receptor and transducer, yields a distinct fluorescence response i.e., turn-on response towards non-metalloproteins and turn-off response towards metalloproteins, and leads to their detection and discrimination.
April 17, 2018: Chemical Communications: Chem Comm
Wei Lin, Ruifen Jiang, Yong Shen, Yaxin Xiong, Sizi Hu, Jianqiao Xu, Gangfeng Ouyang
Pre-equilibrium passive sampling is a simple and promising technique for studying sampling kinetics, which is crucial to determine the distribution, transfer and fate of hydrophobic organic compounds (HOCs) in environmental water and organisms. Environmental water samples contain complex matrices that complicate the traditional calibration process for obtaining the accurate rate constants. This study proposed a QSAR model to predict the sampling rate constants of HOCs (polycyclic aromatic hydrocarbons (PAHs), polychlorinated biphenyls (PCBs) and pesticides) in aqueous systems containing complex matrices...
April 13, 2018: Science of the Total Environment
Dan Zheng, Li Zhang, Qing-Feng Zhang
Astilbin is the most predominant flavonoid in Rhizoma Smilacis Glabrae (RSG) with many bioactivities. The interconversion of the astilbin and its three stereoisomers was found with incubation of RSG extract at different temperatures, and the equilibrium ratios were calculated. Under certain conditions, neoastilbin would replace astilbin and become the predominant flavonoid in RSG extract. The effects of ascorbic acid, sucrose, sodium benzoate, β-cyclodextrin (β-CD) and common metal ions on the isomerization and decomposition of astilbin were studied...
April 6, 2018: Journal of Pharmaceutical and Biomedical Analysis
Kanta Yanagi, Norifumi L Yamada, Kazuaki Kato, Kohzo Ito, Hideaki Yokoyama
Dense polymer brushes with closely packed rotaxane structures were formed at the interface of water and a styrene-butadiene elastomer by spontaneous segregation of an amphiphilic polyrotaxane (PR), a mechanically interlocked polymer consisting of hydrophobic polybutadiene threading through multiple hydrophilic γ-cyclodextrin (γ-CD) derivatives. Segrega-tion of PR at the water/elastomer interface was suggested by X-ray photoelectron spectroscopy. The polymer brush structure at the water interface was investigated using neutron reflectometry...
April 13, 2018: Langmuir: the ACS Journal of Surfaces and Colloids
Meng-Meng Song, Ya-Min Wang, Bing Wang, Xiang-Yong Liang, Zhi-Yi Chang, Bang-Jing Li, Sheng Zhang
The research of hydrogel has been increasingly focused on designing effective energy dissipation structure in recent years. Here, we report a kind of novel supramolecular crosslinkers, which formed by self-assembling amphiphilic block copolymers with guest groups at the end and vinyl functionalized cyclodextrin (CD) through host guest interaction. These crosslinkers could dissipate energy effectively since they combined multiple sacrificial mechanisms across multi-scales through physical interactions. The resulted hydrogel shows distinguishing mechanical properties (fracture toughness of 2...
April 13, 2018: ACS Applied Materials & Interfaces
Francesco Brigo, Antonio Leo, Emilio Russo, Pasquale Striano, Vincenzo Belcastro
Recently, an intravenous formulation of carbamazepine (CBZ) (sulphobutylether-7-beta-cyclodextrine carbamazepine, SBECD CBZ) has been developed and approved by the U.S. Food and Drug Administration. It is indicated as a short-term replacement therapy for oral CBZ formulations, when oral administration is temporarily not feasible and in adults with focal seizures with complex symptomatology as well as generalized tonic-clonic seizures and mixed seizure patterns. Areas covered: This review focuses on the drug development, pharmacokinetics and pharmacodynamics of intravenous CBZ and provides a comprehensive overview of the studies assessing its clinical efficacy, tolerability and safety in adults with epilepsy...
April 12, 2018: Expert Opinion on Pharmacotherapy
Shun Duan, Jia Li, Nana Zhao, Fu-Jian Xu
Self-assembly is a promising method for the construction of multifunctional nanohybrids for biomedical application. In this work, self-assembled multifunctional nanohybrids with a controllable disassembly property have been successfully fabricated. By modification with cyclodextrin (CD)-decorated ethylenediamine-functionalized poly(glycidyl methacrylate) (PGED), CD groups and polycations were conjugated onto Au nanorods (Au NRs) or Fe3O4 nanoparticles (denoted as Au-PGED-CD or Fe3O4-PGED-CD), and different SiO2@Fe3O4-PGED (SFP) or SiO2@Au-PGED (SAP) nanohybrids were readily fabricated by the host-guest interaction between Au-PGED-CD or Fe3O4-PGED-CD and adamantyl (Ad)-functionalized chiral silica NRs under mild conditions...
April 12, 2018: Nanoscale
William A Banks
No abstract text is available yet for this article.
2018: Current Pharmaceutical Design
Saara Mikkonen, Wolfgang Thormann
Computer simulation was utilized to characterize the electrophoretic processes occurring after reactant mixing in an on-line assay format used for monitoring the enantioselective N-demethylation of ketamine to norketamine in presence of highly sulfated γ-cyclodextrin (HS-γ-CD). The incubated reaction mixture (at pH 7.4 and without chiral selector) is bracketed by a low pH BGE containing 2 % HS-γ-CD as chiral selector, thereby forming a discontinuous buffer system. Upon power application, simulation provides insight into the formation of moving boundaries and new zones together with the prediction of the behavior of ketamine and norketamine enantiomers...
April 12, 2018: Electrophoresis
Rui Zhao, Bin Li, Yong Wang, Wenping Hu
The spatial confinement of conjugated phenyl rotators is a compulsory requirement for the fluorescence enhancement of aggregation induced emission (AIE) molecules. This work reports a novel spatially confined AIE material by restricting several tetraphenylethylene (TPE) molecules around the primary face of β-cyclodextrin (CD) via a Cu(I) catalytic 1,3-dipolar cycloaddition reaction (click chemistry). The spatial confinement effect was found to significantly enhance the fluorescence emission when compared with a single TPE modified CD...
April 8, 2018: Sensors
Parbeen Singh, Xiaohong Ren, Tao Guo, Li Wu, Shailendra Shakya, Yaping He, Caifen Wang, Abi Maharjan, Vikramjeet Singh, Jiwen Zhang
Cyclodextrins nanosponges (CD-NSPs) are highly microporous crosslinked polymers with potential applications in the delivery of small and macro-molecular therapeutic agents. Despite the potent host-guest inclusion property, their inherent lack of cellular binding ability has limited applications in drug delivery. Herein, we functionalized the surface of β-cyclodextrin nanosponge (β-CD-NSP) with cholesterol, which is endogenous physiological molecules, widely distributed in all cells, and responsible for cell interactions and protein binding...
June 15, 2018: Carbohydrate Polymers
Xing Li, Ao Yu Chen, Yang Wu, Li Wu, Lei Xiang, Hai Ming Zhao, Quan Ying Cai, Yan Wen Li, Ce Hui Mo, Ming Hung Wong, Hui Li
A pot experiment was conducted to investigate the effect of a series of β-cyclodextrin (β-CD) concentrations on bioremediation of soil co-contaminated with Cd and BDE-209 using amaranth and the white-rot fungus Phanerochaete chrysosporium, with BDE-209 degrading ability. Results showed that the white-rot fungus was beneficial to the growth of amaranth, Cd uptake and BDE-209 degradation. Addition of β-CD further increased biomass of both shoots and roots, shoot Cd concentrations and contents, chlorophyll concentrations and soil manganese peroxidase (MnP) activities...
April 5, 2018: Science of the Total Environment
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