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https://www.readbyqxmd.com/read/28821436/carbon-quantum-dot-tailored-calcium-alginate-hydrogel-for-ph-responsive-controlled-delivery-of-vancomycin
#1
Niladri Sarkar, Gyanaranjan Sahoo, Rashmita Das, Gyanaranjan Prusty, Sarat K Swain
Herein, we demonstrate the preparation of highly luminescent carbon quantum dots (CQDs) from Aloe vera leaf gel; in just 2h at 250°C through carbonization pathway. The prepared CQDs are structurally characterized with high resolution transmission electron microscopy (HRTEM), hydrodynamic diameter and surface polarity, Fourier transform infrared spectroscopy (FTIR), X-ray photoelectron spectroscopy (XPS), Raman, UV-visible absorption spectrophotometry and fluorescence spectroscopy. The functional carbon nanoparticles are observed as non-cytotoxic materials...
August 15, 2017: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28821156/physicochemical-interactions-of-cycloamylose-with-phenolic-compounds
#2
Shin-Joung Rho, Saehun Mun, Jung Sun Hong, Young-Lim Kim, Ha V Do, Young-Wan Kim, Sang-Ik Han, Yong-Ro Kim
The complex formation capability of cycloamylose (CA), having a degree of polymerization of 23-45, with phenolic compounds (PCs) was investigated using various physicochemical techniques. The fluorescence intensity of PCs increased and then reached a plateau at 10-20mM cyclodextrin, while it continued to increase at up to 60mM CA. Thermodynamic data of CA complexes with PCs revealed that the binding process was primarily enthalpy-driven and spontaneous. CA favored to form the most stable complex with chlorogenic acid (CHA) among all PCs...
October 15, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28821141/designed-biocompatible-nano-inhibitor-based-on-poly-%C3%AE-cyclodextrin-ester-for-reduction-of-the-dehp-migration-from-plasticized-pvc
#3
Ahmad Raeisi, Khalil Faghihi, Meisam Shabanian
The easy migration of di(2-ethylhexyl) phthalate (DEHP) from the plasticized PVC (P-PVC) poses a serious threat to human health and the ecosystems. Thus, its control migration from the P-PVC products is very important. In this work, a poly(β-cyclodextrin-ester) network (β-CDP) was synthesized via reaction of β-cyclodextrin with 3,3',4,4'-benzophenone tetracarboxylic dianhydride. As a potential inhibitor for reduction of the DEHP migration, the β-CDP was grafted to Fe3O4 nanoparticles. Poly(β-cyclodextrin-ester) functionalized Fe3O4 nanoparticles (MNP-CDP) has been used in PVC/DEHP system as a reactive nano-inhibitor to reduce DEHP migration...
October 15, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28821134/graphene-cyclodextrin-based-nanocomposite-hydrogel-with-enhanced-strength-and-thermo-responsive-ability
#4
Pang Zhu, Yonghong Deng, Chaoyang Wang
Dual crosslinked system has been proved to be an efficient method to obtain tough and high strength hydrogels. Herein, we synthesized a novel graphene oxide/p(acrylamide-co-poly(ethylene glycol) methyl ether methacrylate)/α-cyclodextrin (GO/P(AM-co-PEGMA)/CD) physical dual crosslinked hydrogel via copolymerization of AM and PEGMA in the α-CD/GO solution. The polymer main chains adsorb onto the GO surface resulting in the first crosslinked system and multiple hydrogen bonds between α-CDs that thread on the PEGMA side chains establish the second crosslinked system...
October 15, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28821132/the-effect-of-%C3%AE-cyclodextrin-on-poly-pseudo-rotaxane-nanoparticles-self-assembled-by-protoporphyrin-modified-poly-ethylene-glycol-for-anticancer-drug-delivery
#5
Taotao Xu, Junhua Li, Jun Cao, Wenxia Gao, Li Li, Bin He
Poly(pseudo)rotaxane (PPR) nanoparticles was facilely prepared using poly(ethylene glycol) (PEG) modified with protoporphyrin (PpIX) and α-cyclodextrin (α-CD) via host-guest interaction, the effect of α-CD number on the nanoparticle properties was investigated. The PEG with protoporphyrin (PEG-PpIX) end capping was synthesized via coupling reaction and the poly(pseudo)rotaxane nanoparticles with different amount of α-CD were fabricated by host-guest interaction between mPEG-PpIX and α-CDs. The final product was characterized by nuclear magnetic spectrum ((1)H NMR), X-ray diffraction (XRD), atomic force microscope (AFM) and dynamic light scattering (DLS)...
October 15, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28821116/active-release-coating-of-multilayer-assembled-branched-and-ionic-%C3%AE-cyclodextrins-onto-poly-ethylene-terephthalate
#6
Leyre Pérez-Álvarez, Leire Ruiz-Rubio, Erlantz Lizundia, Estíbaliz Hernáez, Luis M León, Jose Luis Vilas-Vilela
Branched ionic cyclodextrins multilayers were assembled onto the surface of previously aminolyzed poly(ethylene terephthalate) in order to construct local drug delivery tailored platforms with potential applicability as materials for indwelling medical devices. The construction of the multilayers took place by the alternate deposition of ionic cyclodextrin derivatives and was characterized by surface zeta-potential measurements, X-ray photoelectron spectroscopy and, after fluorescent labeling of anionic branched cyclodextrins, by UV-vis spectroscopy and confocal fluorescence spectroscopy...
October 15, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28821031/surface-deacetylated-chitin-nanofibers-reinforced-with-a-sulfobutyl-ether-%C3%AE-cyclodextrin-gel-loaded-with-prednisolone-as-potential-therapy-for-inflammatory-bowel-disease
#7
Ryo Tabuchi, Makoto Anraku, Daisuke Iohara, Takako Ishiguro, Shinsuke Ifuku, Tomone Nagae, Kaneto Uekama, Shoko Okazaki, Keizo Takeshita, Masaki Otagiri, Fumitoshi Hirayama
Surface-deacetylated chitin nanofibers (SDACNFs) reinforced with a sulfobutyl ether β-cyclodextrin (SBE-β-CD) (NFs-CDs) gel were developed to obtain a controlled release carrier of prednisolone (PD) for the treatment of colitis. PD was released slowly from the gel at both pH 1.2 and 6.8. The in vitro slow release of PD from the NFs-CDs gel was reflected in the in vivo absorption of the drug after oral administration to rats. These results suggest that a simple gel composed of a mixture of SDACNFs and SBE-β-CD has the potential for use in the controlled release of PD...
October 15, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28820972/fluorescent-pseudorotaxanes-of-a-quinodicarbocyanine-dye-with-gamma-cyclodextrin
#8
Olivia M Bernstein, Tiffany E McGee, Lisa E Silzel, John W Silzel
Spectrophotometric titration of buffered solutions of gamma cyclodextrin (γCD) and 1,1'-diethyl,2,2'-dicarbocyanine (DDI) demonstrates extension of the known 1:2 host:guest complex to form a previously unreported 2:2 complex near the γCD solubility limit. Though DDI is predominantly hosted as a non-fluorescent H-aggregate, both complexes exist in respective equilibria with two secondary complexes hosting unaggregated DDI as 1:1 and 2:1 complexes. The 2:1 complex exhibits significant fluorescence emission, with a quantum yield six times that of DDI in organic solvents, but ten times lower than that of an analogous indodicarbocyanine...
August 3, 2017: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/28820940/polyoxometalate-cationic-cluster-and-%C3%AF-%C3%AE-cyclodextrin-from-primary-interactions-to-supramolecular-hybrid-materials
#9
Mhamad Aly Moussawi, Nathalie Leclerc-Laronze, Sébastien Floquet, Pavel A Abramov, Maxim Nailyevich Sokolov, Stephane Cordier, Anne Ponchel, Eric Monflier, Herve Bricout, David Landy, Mohamed Haouas, Jerome Marrot, Emmanuel Cadot
Herein, we report on a three-component supramolecular hybrid system built from specific recognition processes involving a Dawson type polyoxometalate [P2W18O62](6-,) a cationic electron-rich cluster {[Ta6Br12(H6O)6]@2CD}(2+) and γ-cyclodextrin. Investigations of such a class of materials have been conducted using bottom-up approach by studying the specific interactions between -CD and both types of inorganic units. Their ability to interact has been investigated in the solid state by single-crystal X-ray diffraction and in solution using multinuclear NMR methods (including DOSY, EXSY and COSY), ESI-mass and UV-vis spectroscopies, electrochemistry and ITC experiments...
August 18, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28815793/responsiveness-and-morphology-study-of-dual-stimuli-controlled-supramolecular-polymer
#10
Chenxiao Xiong, Meiran Xie, Ruyi Sun
The synthesis and characterization of a linear supramolecular polymer formed by dual host-guest recognitions is presented. The polymer linked by the orthogonal interactions of azobenzene with β-cyclodextrin and methyl viologen with sulfonatocalix[4]arene is constructed, and the morphology change along with the formation and vanishment of host-guest interaction is investigated. The reversible disassembly-reassembly of the polymer induced by light and the redox process are monitored by UV-vis and cyclic voltammetry, respectively...
August 16, 2017: Macromolecular Rapid Communications
https://www.readbyqxmd.com/read/28811020/peanut-agglutinin-and-%C3%AE-cyclodextrin-functionalized-polymer-monolith-microextraction-of-igg-galactosylation-coupled-with-online-ms-detection
#11
Haijiao Zheng, Tenggao Zhu, Xiqian Li, Jiutong Ma, Qiong Jia
A facile online method coupling polymer monolithic microextraction (PMME) with mass spectrometry (MS) was developed for the detection of Immunoglobulin G (IgG) galactosylation glycopeptides. A peanut agglutinin-β-cyclodextrin (PNA-β-CD) functionalized poly(hydroxyethyl methylacrylate-ethyleneglycol dimethacrylate) monolith was designed via a click reaction. Thanking to the specificity of PNA-β-CD for the targets, the material exhibited enhanced enrichment selectivity and extraction efficiency for IgG galactosylation glycopeptides...
August 29, 2017: Analytica Chimica Acta
https://www.readbyqxmd.com/read/28809977/correlation-between-collective-and-molecular-dynamics-in-ph-responsive-cyclodextrin-based-hydrogels
#12
C Bottari, L Comez, S Corezzi, F D'Amico, A Gessini, A Mele, C Punta, L Melone, A Pugliese, C Masciovecchio, B Rossi
UV Raman and Brillouin light scattering (BLS) experiments have been used in this study to explore the complex phase change behavior occurring in pH-responsive polysaccharide hydrogels as a function of temperature. Due to the different physical quantities measured by the two techniques, the joint analysis of Raman and BLS spectra has provided an unprecedented large-scale characterization of the molecular rearrangements and of the different kinds of hydrophilic and hydrophobic interactions that cooperate to determine the phase transformation observed in these hydrogels during the heating of the gel...
August 15, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28809447/pulmonary-delivery-of-tea-tree-oil-%C3%AE-cyclodextrin-inclusion-complexes-for-the-treatment-of-fungal-and-bacterial-pneumonia
#13
Miao Li, Lifei Zhu, Tongtong Zhang, Boming Liu, Lina Du, Yiguang Jin
OBJECTIVES: Bacterial pneumonia is a common cause of death worldwide. Tea tree oil (TTO) is a potent antimicrobial natural product, which is formulated in dry powder inhalers (DPIs) for the treatment of fungal and bacterial pneumonia. METHODS: Tea tree oil-β-cyclodextrin inclusion complexes (TTO-β-CD) were prepared and characterized. Aerodynamic properties of TTO-β-CD powders were measured. The rat models of fungal (Candida albicans) and bacterial (Acinetobacter baumannii) pneumonia were prepared...
August 15, 2017: Journal of Pharmacy and Pharmacology
https://www.readbyqxmd.com/read/28809107/synthesis-and-insecticidal-activity-of-enzyme-triggered-functionalized-hollow-mesoporous-silica-for-controlled-release
#14
Amir Esmat Kaziem, Yunhao Gao, Shun He, Jianhong Li
In the present study, enzymatic responsive controlled release formulations (CRFs) were fabricated. The CRFs were achieved by anchoring mechanically interlocked molecules using α-cyclodextrin onto the surface pore rims of hollow mesoporous silica (HMS). The CRFs were characterized using Fourier transform infrared spectroscopy, scanning electron microscope, transmission electron microscope, and thermogravimetric analysis. The results showed that the CRFs had extraordinary loading ability for chlorantraniliprole (42% w/w) and could effectively preserve chlorantraniliprole against degradation under thermal conditions and UV radiation...
August 15, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28806570/chiral-separation-of-terbutaline-and-non-steroidal-anti-inflammatory-drugs-by-using-a-new-lysine-bridged-hemispherodextrin-in-capillary-electrophoresis
#15
V Cucinotta, M Messina, A Contino, G Maccarrone, S Orlandini, A Giuffrida
A method for the separation of a mixture of terbutaline and non-steroidal anti-inflammatory drugs was developed using capillary electrophoresis with a new hemispherodextrin, ad hoc designed, the lysine - bridged hemispherodextrin (THLYSH). The use of lysine residues to bridge the trehalose capping unit moiety to the cyclodextrin cavity gives rise to a receptor with two long chains with amine nitrogen atoms, whose charge can be easily tuned as a function of the solution pH. The new hemispherodextrin was accurately characterised by ESI-MS and NMR spectroscopy, also highlighting its protonation behaviour...
August 3, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/28806512/painkiller-isoxicam-and-its-copper-complex-can-form-inclusion-complexes-with-different-cyclodextrins-a-fluorescence-fourier-transform-infra-red-spectroscopy-and-nuclear-magnetic-resonance-study
#16
Sathi Goswami, Anupa Majumdar, Munna Sarkar
The interaction of a painkiller Isoxicam, belonging to the oxicam group of Non Steroidal Anti-Inflammatory Drugs (NSAIDs) and its copper complex with different cyclodextrins (β-CD, γ-CD, HPβCD and HPγCD ) has been investigated in both solution and the solid state. Steady state and time resolved fluorescence spectroscopy, fluorescence anisotropy, 1H NMR and FTIR spectroscopy are used. Both the drug and its copper complex form host-guest inclusion complex with all CDs. Fluorescence spectroscopy is used to determine binding constants and stoichiometries of the host-guest complex...
August 14, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/28803710/intrathecal-2-hydroxypropyl-%C3%AE-cyclodextrin-decreases-neurological-disease-progression-in-niemann-pick-disease-type-c1-a-non-randomised-open-label-phase-1-2-trial
#17
Daniel S Ory, Elizabeth A Ottinger, Nicole Yanjanin Farhat, Kelly A King, Xuntian Jiang, Lisa Weissfeld, Elizabeth Berry-Kravis, Cristin D Davidson, Simona Bianconi, Lee Ann Keener, Ravichandran Rao, Ariane Soldatos, Rohini Sidhu, Kimberly A Walters, Xin Xu, Audrey Thurm, Beth Solomon, William J Pavan, Bernardus N Machielse, Mark Kao, Steven A Silber, John C McKew, Carmen C Brewer, Charles H Vite, Steven U Walkley, Christopher P Austin, Forbes D Porter
BACKGROUND: Niemann-Pick disease, type C1 (NPC1) is a lysosomal storage disorder characterised by progressive neurodegeneration. In preclinical testing, 2-hydroxypropyl-β-cyclodextrins (HPβCD) significantly delayed cerebellar Purkinje cell loss, slowed progression of neurological manifestations, and increased lifespan in mouse and cat models of NPC1. The aim of this study was to assess the safety and efficacy of lumbar intrathecal HPβCD. METHODS: In this open-label, dose-escalation phase 1-2a study, we gave monthly intrathecal HPβCD to participants with NPC1 with neurological manifestation at the National Institutes of Health (NIH), Bethesda, MD, USA...
August 10, 2017: Lancet
https://www.readbyqxmd.com/read/28800463/combination-of-dexamethasone-and-avastin-%C3%A2-by-supramolecular-hydrogel-attenuates-the-inflammatory-corneal-neovascularization-in-rat-alkali-burn-model
#18
Jinhai Huang, Wenwen Wang, Jing Yu, Xinxin Yu, Qianqian Zheng, Fangli Peng, Zhifen He, Wenguang Zhao, Zhaoliang Zhang, Xingyi Li, Qinmei Wang
Corneal neovascularization (CNV) is one of the leading causes of vision loss and a high-risk factor for transplant rejection. The present study proposed a supramolecular hydrogel comprised of MPEG-PCL micelles and α-cyclodextrin (α-CD) for co-delivery of dexamethasone sodium phosphate (Dexp) and Avastin(®) (Ava), and further evaluated its therapeutic efficacy in rat alkali burn model. A physical mixing of Dexp/Ava, MPEG-PCL micelles, and α-CD aqueous solution leads to a spontaneous formation of the supramolecular hydrogel via a "host-guest" recognition between MPEG and α-CD...
July 25, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28800107/sequestration-effect-on-the-open-cyclic-switchable-property-of-warfarin-induced-by-cyclodextrin-time-resolved-fluorescence-study
#19
Naji Al-Dubaili, Na'il Saleh
The excited-state lifetimes of the anticoagulant drug warfarin (W) in water and in the absence and presence of methyl-β-cyclodextrins (Me-β-CD) were recorded using time-resolved fluorescence measurements. Selective excitation of the open and cyclic protonated isomers of W were acquired with laser emitting diodes (LED) producing 320 and 280 nm excitation pulses, respectively. Formation of the inclusion complex was checked by UV-visible absorption spectroscopy, and the values of binding constants (2.9 × 10³ M(-1) and 4...
August 11, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28799761/-19-f-nmr-characterization-of-the-encapsulation-of-emerging-perfluoroethercarboxylic-acids-by-cyclodextrins
#20
Mary Jo Weiss-Errico, Ion Ghiviriga, Kevin E O'Shea
Legacy perfluoroalkyl substances (PFASs) are known environmental pollutants with serious adverse health effects. Perfluoroethercarboxylic acids (PFECAs), emerging PFASs now being substituted for legacy PFASs, have recently been detected in the environment. Cyclodextrins (CDs) have been proposed as agents for the remediation of problematic pollutants, including legacy PFASs. The current study uses (19)F NMR spectroscopy to measure the complexation of mono-, di-, and triether PFECAs by CDs for eventual environmental applications...
August 11, 2017: Journal of Physical Chemistry. B
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