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https://www.readbyqxmd.com/read/29925006/notch-signaling-facilitates-in-vitro-generation-of-cross-presenting-classical-dendritic-cells
#1
Margaret E Kirkling, Urszula Cytlak, Colleen M Lau, Kanako L Lewis, Anastasia Resteu, Alireza Khodadadi-Jamayran, Christian W Siebel, Hélène Salmon, Miriam Merad, Aristotelis Tsirigos, Matthew Collin, Venetia Bigley, Boris Reizis
The IRF8-dependent subset of classical dendritic cells (cDCs), termed cDC1, is important for cross-priming cytotoxic T cell responses against pathogens and tumors. Culture of hematopoietic progenitors with DC growth factor FLT3 ligand (FLT3L) yields very few cDC1s (in humans) or only immature "cDC1-like" cells (in the mouse). We report that OP9 stromal cells expressing the Notch ligand Delta-like 1 (OP9-DL1) optimize FLT3L-driven development of cDC1s from murine immortalized progenitors and primary bone marrow cells...
June 19, 2018: Cell Reports
https://www.readbyqxmd.com/read/29925004/full-functional-knockout-of-placental-growth-factor-by-knockin-with-an-inactive-variant-able-to-heterodimerize-with-vegf-a
#2
Ivana Apicella, Valeria Cicatiello, Dario Acampora, Valeria Tarallo, Sandro De Falco
Placental growth factor (PlGF) is a proangiogenic member of the vascular endothelial growth factor (VEGF) family playing a central role in pathological angiogenesis. PlGF-DE is a PlGF variant unable to bind vascular endothelial growth factor receptor 1 (VEGFR-1) but still able to generate heterodimer with VEGF-A. We have generated PlGF-DE knockin mice that are vital and fertile and show unaltered expression of Plgf, Vegf-a, Vegfr-1, and Vegfr-2 compared with wild-type mice. Interestingly, these mutants showed additional and remarkable angiogenesis impairment in tumor growth, hindlimb ischemia, and choroidal neovascularization compared with both PlGF knockout and wild-type mice...
June 19, 2018: Cell Reports
https://www.readbyqxmd.com/read/29924962/prognostic-value-of-aldehyde-dehydrogenase-1-aldh1-in-invasive-breast-carcinomas
#3
Hale Demir, Ozgecan Dulgar, Bugra Taygun Gulle, Hande Turna, Sennur Ilvan
Aldehyde dehydrogenase 1 (ALDH1) has been identified as a marker of cancer stem cells in breast cancer (BC). Recent studies showed that ALDH1 expression is correlated with poor prognostic parameters and worse clinical outcome in BC. We evaluated ALDH1 expression by immunohistochemistry in a series of 217 invasive BCs and investigated the correlation between ALDH1 expression and clinicopathological parameters, molecular subtypes (luminal A, luminal B, human epidermal growth factor receptor 2 [HER2] type, and triple-negative BC [TNBC]), and patient survival...
June 11, 2018: Bosnian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/29924961/epidermal-growth-factor-egf-promotes-bone-healing-in-surgically-induced-osteonecrosis-of-the-femoral-head-onfh
#4
Ozgur Basal, Tolga Atay, İbrahim Metin Ciris, Yakup Barbaros Baykal
Angiogenic effects of epidermal growth factor (EGF), a potent mitogen, have been demonstrated previously. Moreover, different in vitro studies showed that EGF affects processes associated with bone healing, such as osteoblast differentiation and bone resorption. The aim of this study was to investigate the effect of combined core decompression (CD) and recombinant human EGF (rhEGF) treatment on early-stage osteonecrosis of the femoral head (ONFH) surgically induced in rats. ONFH was induced by dissecting the cervical periosteum and placing a ligature tightly around the femoral neck...
June 11, 2018: Bosnian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/29924958/overexpression-of-mir-361-5p-in-triple-negative-breast-cancer-tnbc-inhibits-migration-and-invasion-by-targeting-rqcd1-and-inhibiting-the-egfr-pi3k-akt-pathway
#5
Jianjun Han, Jingjing Yu, Yuna Dai, Jumei Li, Meiyan Guo, Jingzhen Song, Xuefeng Zhou
Triple-negative breast cancer (TNBC) is the leading cause of cancer-related death in women. Previous studies indicated that miR-361-5p was downregulated in breast cancer, however, the exact effect of miR-361-5p on TNBC requires further investigation. In the present study, we investigated whether miR-361-5p can act as a tumor suppressor by targeting required for cell differentiation 1 homolog (RQCD1) and inhibiting epidermal growth factor receptor (EGFR)/phosphoinositide 3-kinase (PI3K)/protein kinase B (Akt) pathway in TNBC...
June 20, 2018: Bosnian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/29924942/deficient-neurotrophic-factors-of-cspg4-type-neural-cell-exosomes-in-alzheimer-disease
#6
Edward J Goetzl, Carlos Nogueras-Ortiz, Maja Mustapic, Roger J Mullins, Erin L Abner, Janice B Schwartz, Dimitrios Kapogiannis
Exosomes derived from chondroitin sulfate proteoglycan (CSPG) 4 type neural precursor cells (CSPG4Es) were purified from human plasma by sequential immunoabsorption with anti-CSPG4 and anti-platelet growth factor receptor α mAb to characterize the potential in vivo roles of CSPG4 cells in neuronal repair. Hepatocyte growth factor, fibroblast growth factors (FGFs)-2 and -13, and type 1 insulin-like growth factor (IGF-1), which enhance neuronal survival and functions, were quantified in CSPG4E extracts. For CSPG4Es of 24 healthy control subjects, mean levels of hepatocyte growth factor, FGF-13, and IGF-1, but not FGF-2, were significantly higher by up to 7-fold than in their neuronal-derived exosomes, and mean levels of all 4 growth factors were significantly higher by up to 8-fold than in their astrocyte-derived exosomes...
June 20, 2018: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/29924913/mir-27b-3p-is-involved-in-doxorubicin-resistance-of-human-anaplastic-thyroid-cancer-cells-via-targeting-ppar%C3%AE
#7
Yuan Xu, Yi-Fan Han, Bing Ye, Yin-Long Zhang, Jian-Da Dong, Shao-Jun Zhu, Jiong Chen
Chemotherapy is one of the most effective forms of cancer treatment. It has been widely used in the treatment of various malignant tumors. In order to investigate molecular mechanisms responsible for the chemoresistance of anaplastic thyroid cancer (ATC), we established the doxorubicin (Dox) resistance of human ATC SW1736 and 8305C cells and named them SW1736/Dox and 8305C/Dox, respectively. We evaluated the expression of various micro-RNAs (miRNAs) between control and Dox-resistant ATC cells and found that the expression of miR-27b-3p was significantly increased in Dox-resistant ATC cells...
June 20, 2018: Basic & Clinical Pharmacology & Toxicology
https://www.readbyqxmd.com/read/29924857/depth-and-coral-cover-drive-the-distribution-of-a-coral-macroborer-across-two-reef-systems
#8
Rebecca L Maher, Michelle A Johnston, Marilyn E Brandt, Tyler B Smith, Adrienne M S Correa
Bioerosion, the removal of calcium carbonate from coral frameworks by living organisms, influences a variety of reef features, from their topographic complexity to the net balance of carbonate budgets. Little is known, however, about how macroborers, which bore into reef substrates leaving traces greater than 0.1 mm diameter, are distributed across coral reefs, particularly reef systems with high (>50%) stony coral cover or at mesophotic depths (≥30 m). Here, we present an accurate and efficient method for quantifying macroborer densities from stony coral hosts via image analysis, using the bioeroding barnacle, Lithotrya dorsalis, and its host coral, Orbicella franksi, as a case study...
2018: PloS One
https://www.readbyqxmd.com/read/29924832/transcriptome-analysis-of-near-isogenic-line-provides-novel-insights-into-genes-associated-with-panicle-traits-regulation-in-rice
#9
Wuhan Zhang, Pingyong Sun, Qiang He, Fu Shu, Huafeng Deng
Panicle traits in rice impact yield and quality. The OsGRF4 gene encodes a growth-regulating factor controlling panicle traits, and was recently cloned. Gene expression profiling analysis can be used to study the molecular mechanisms underlying OsGRF4 regulation. Use of near-isogenic lines (NILs) reduces genetic background noise in omics studies. We compared transcriptome profiling of 7 cm long young panicles of NIL-Osgrf4 and NIL-OsGRF4 using RNAs sequence analyses. Eighty differentially expressed genes (DEGs) were identified...
2018: PloS One
https://www.readbyqxmd.com/read/29924731/il-37-affects-the-occurrence-and-development-of-endometriosis-by-regulating-the-biological-behavior-of-endometrial-stromal-cells-through-multiple-signaling-pathways
#10
Jianfa Jiang, Kenan Yu, Zhaoying Jiang, Min Xue
Endometriosis (EMs) is a chronic inflammatory condition. Interleukin (IL)-37 is a member of the IL-1 family and an anti-inflammatory cytokine. This study aimed to evaluate the possible role of IL-37 in the EMs pathogenesis. We investigated the in vivo effect of IL-37 on EMs by injection with recombinant human IL-37 (rhIL-37) into EMs mice. Furthermore, we evaluated the in-vitro effects of IL-37 on proliferation, adhesion, migration, and invasiveness of endometrial stromal cells (ESCs), and explored whether Wnt/β-catenin and mitogen-activated protein kinase (MAPK) pathways were involved in this process...
June 1, 2018: Biological Chemistry
https://www.readbyqxmd.com/read/29924595/angiogenesis-and-full-thickness-wound-healing-efficiency-of-copper-doped-borate-bioactive-glass-poly-lactic-co-glycolic-acid-dressing-loaded-with-vitamin-e-in-vivo-and-in-vitro
#11
Haoran Hu, Yue Tang, Libin Pang, Cunlong Lin, Wenhai Huang, Deping Wang, Weitao Jia
There is an urgent demand for wound healing biomaterials because of the increasing frequency of traffic accidents, industrial contingencies and natural disasters. Borate bioactive glass has potential applications in bone tissue engineering and wound healing; however, its uncontrolled release runs a high risk of rapid degradation and transient biotoxicity. In this study, a novel organic-inorganic dressing of copper-doped borate bioactive glass/poly(lactic-co-glycolic acid) loaded with vitamin E (0-3.0 wt.% vitamin E) was fabricated to evaluate its efficiency for angiogenesis in cells and full-thickness skin wounds healing in rodents...
June 20, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29924446/significance-of-psmad2-3-and-smad4-in-hepatitis-c-virus-related-liver-fibrosis-and-hepatocellular-carcinoma
#12
Mona Mohammed Moussa, Noha Said Helal, Mohieldin Magdy Youssef
Chronic hepatitis C (CHC) is a major public health problem, especially in Egypt. Risk of hepatocellular carcinoma (HCC) development increases as hepatitis C virus (HCV)-related liver diseases progress. Smads act as substrates for the transforming growth factor-beta (TGF-β) family of receptors. This study aims to assess hepatic expression of pSmad2/3 and Smad4 in CHC with different stages of fibrosis and grades of necro-inflammation as well as in HCC on top of CHC. This study was done on 33 core liver biopsies from patients with CHC (15 with early fibrosis and 18 with late fibrosis), 15 liver specimens from HCC cases on top of CHC, as well as five normal controls...
June 2018: APMIS: Acta Pathologica, Microbiologica, et Immunologica Scandinavica
https://www.readbyqxmd.com/read/29924384/glycans-in-stem-cell-regulation-from-drosophila-tissue-stem-cells-to-mammalian-pluripotent-stem-cells
#13
REVIEW
Shoko Nishihara
Cell surface glycans, which are tissue-specific and developmentally regulated, work as essential modulators in ligand-receptor interactions, binding to various signal ligands including Wnt, Hedgehog, fibroblast growth factors, epidermal growth factors, and bone morphogenetic proteins, as well as in cell-cell interactions and cell-extracellular matrix interactions. These signals are essential for the stemness and differentiation of various kinds of stem cells. In addition, the intracellular O-linked N-acetylglucosamine, a form of glycosylation found only on nuclear or cytoplasmic proteins, regulates core transcription factors of stemness and phosphorylation of downstream signal components...
June 20, 2018: FEBS Letters
https://www.readbyqxmd.com/read/29924349/aesthetic-journeys-a-review-of-cosmetic-surgery-tourism
#14
Ryan Terence Pereira, Carmel M Malone, Gerard T Flaherty
Background: Medical tourism has witnessed significant growth in recent years. The emerging trend towards international travel for cosmetic surgical interventions has not previously been reviewed. The current review aims to critically address the scale and impact of cosmetic surgical tourism and to delineate the complication profile of this form of medical tourism. Methods: Articles published in the English language on the PubMed database that were relevant to surgical tourism and the complications of elective surgical procedures abroad were examined...
June 1, 2018: Journal of Travel Medicine
https://www.readbyqxmd.com/read/29924321/relative-weight-gain-through-age-4-years-is-associated-with-increased-adiposity-and-higher-blood-pressure-and-insulinemia-at-4-5-years-of-age-in-mexican-children
#15
Ivonne Ramirez-Silva, Juan A Rivera, Belem Trejo-Valdivia, Aryeh D Stein, Reynaldo Martorell, Isabelle Romieu, Albino Barraza-Villarreal, Laura Avila-Jiménez, Usha Ramakrishnan
Background: Rapid early weight gain has been associated with increased risk of obesity and cardiometabolic alterations, but evidence in low and middle-income countries is inconclusive. Objective: We evaluated the relation between relative weight gain from 1 to 48 mo with adiposity and cardiometabolic risk factors at 4-5 y of age, and determined if adiposity is a mediator for cardiometabolic alterations. Methods: We studied 428 Mexican children with anthropometric and blood pressure (BP) information from birth to 5 y of age from POSGRAD (Prenatal Omega-3 fatty acid Supplementation and child GRowth And Development), of whom 334 provided measures of adiposity and cardiometabolic risk markers at 4 y...
June 19, 2018: Journal of Nutrition
https://www.readbyqxmd.com/read/29924305/telocytes-promote-vegf-expression-and-alleviate-ventilator-induced-lung-injury-in-mice
#16
Ruihua Ma, Pinwen Wu, Qiqing Shi, Dongli Song, Hao Fang
Mechanical ventilation (MV) is an important procedure for the treatment of patients with acute lung injury or acute respiratory distress syndrome in a clinical setting; however, MV can lead to severe complications, including ventilator-induced lung injury (VILI). Telocytes (TCs) can promote tissue repair following injury in the heart, kidneys, and other organs. The aim of this study was to investigate the role of TCs in VILI in mice and the associated mechanisms. By using in vivo studies in mice and in vitro studies in cells, we demonstrated that an airway injection of TCs can reduce the pulmonary inflammatory response and improve the lung function in mice with VILI and promote the proliferation of pulmonary vascular endothelial cells...
June 19, 2018: Acta Biochimica et Biophysica Sinica
https://www.readbyqxmd.com/read/29924302/role-of-proteoglycans-and-glycosaminoglycans-in-duchenne-muscular-dystrophy
#17
Laurino Carmen, Vadala Maria, Julio Cesar Morales-Medina, Annamaria Vallelunga, Beniamino Palmieri, Tommaso Iannitti
Duchenne Muscular dystrophy (DMD) is an inherited fatal X-linked myogenic disorder with a prevalence of 1 in 3500 male live births. It affects voluntary muscles, and heart and breathing muscles. DMD is characterised by continuous degeneration and regeneration cycles resulting in extensive fibrosis and a progressive reduction in muscle mass. Since the identification of a reduction in dystrophin protein as the cause of this disorder, numerous innovative and experimental therapies, focusing on increasing the levels of dystrophin, have been proposed, but the clinical improvement has been unsatisfactory...
June 19, 2018: Glycobiology
https://www.readbyqxmd.com/read/29924037/factors-predicting-2-year-treatment-results-of-ranibizumab-therapy-for-polypoidal-choroidal-vasculopathy-in-eyes-with-good-baseline-visual-acuity
#18
Ryusaburo Mori, Koji Tanaka, Mitsuko Yuzawa
This study aimed to explore predictors of long-term stabilization of polypoidal choroidal vasculopathy (PCV) lesions and vision in response to injection of intravitreal ranibizumab (IVR). The treated eyes had a baseline best corrected visual acuity (BCVA) of at least 0.6 (logarithm of the minimal angle of resolution (logMAR) 0.22).We treated 45 eyes showing BCVA between 0.6 (logMAR 0.22) and 1.0 (logMAR 0), with IVR for 3 consecutive months. All eyes were confirmed to have subfoveal PCV prior to starting this treatment regimen...
June 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29923978/correlations-between-health-promoting-lifestyle-and-health-related-quality-of-life-among-elderly-people-with-hypertension-in-hengyang-hunan-china
#19
Jianzhi Li, Jiangdong Yu, Xi Chen, Xuewen Quan, Lan Zhou
Hypertension is considered as an important public health problem in developed and developing countries. The disease is closely associated with health-promoting lifestyle (HPL), and it seems that HPL plays an important role in improving health-related quality of life (HRQOL). This cross-sectional study is to investigate the effects of health-promoting lifestyle (HPL) on health-related quality of life in elderly people with hypertension from a community health service center in Hengyang, Hunan, PR China.Totally 530 elderly patients with hypertension from the community health service center were included in this study, who were asked to fill in a questionnaire (504 patients responded)...
June 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29923601/alfalfa-response-to-heat-stress-is-modulated-by-microrna156
#20
Craig Matthews, Muhammad Arshad, Abdelali Hannoufa
Heat stress and extreme temperatures negatively affect plant development by disrupting regular cell and biochemical functions, ultimately leading to reducing crop production. Alfalfa (Medicago sativa) is an important forage crop grown world-wide as forage for livestock feed. Limiting the effects of abiotic stress by developing alfalfa cultivars that are stress tolerant would help mitigate losses to crop production. Members of the microRNA156 (miR156) family regulate the Squamosa Promoter-Binding Protein-like (SPL) genes that in turn impact plant growth and development by regulating downstream genes in response to various abiotic stresses...
June 20, 2018: Physiologia Plantarum
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