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https://www.readbyqxmd.com/read/28810369/a-closer-look-at-the-relationships-between-panic-attacks-emergency-department-visits-and-non-cardiac-chest-pain
#1
Guillaume Foldes-Busque, Isabelle Denis, Julien Poitras, Richard P Fleet, Patrick Archambault, Clermont E Dionne
This study examined the prevalence of emergency department visits prompted by panic attacks in patients with non-cardiac chest pain. A validated structured telephone interview was used to assess panic attacks and their association with the emergency department consultation in 1327 emergency department patients with non-cardiac chest pain. Patients reported at least one panic attack in the past 6 months in 34.5 per cent (95% confidence interval: 32.0%-37.1%) of cases, and 77.1 per cent (95% confidence interval: 73...
January 1, 2017: Journal of Health Psychology
https://www.readbyqxmd.com/read/28808897/should-posttraumatic-stress-be-a-disorder-or-a-specifier-towards-improved-nosology-within-the-dsm-categorical-classification-system
#2
REVIEW
Jeffrey Guina, Matthew Baker, Kelly Stinson, Jon Maust, Joseph Coles, Pamela Broderick
PURPOSE OF REVIEW: Since 1980, posttraumatic stress (PTS) disorder has been controversial because of its origin as a social construct, its discriminating trauma definition, and the Procrustean array of symptoms/clusters chosen for inclusion/exclusion. This review summarizes the history of trauma-related nosology and proposed changes, within current categorical models (trauma definitions, symptoms/clusters, subtypes/specifiers, disorders) and new models. RECENT FINDINGS: Considering that trauma is a risk factor for virtually all mental disorders (particularly depressive, anxiety, dissociative, personality), the multi-finality of trauma (some survivors are resilient, and some develop PTS and/or non-PTS symptoms), and the various symptoms that trauma survivors express (mood, cognitive, perceptual, somatic), it is difficult to classify PTS...
August 15, 2017: Current Psychiatry Reports
https://www.readbyqxmd.com/read/28799955/a-serotonergic-deficit-in-the-dorsal-periaqueductal-gray-matter-may-underpin-enhanced-panic-like-behavior-in-diabetic-rats
#3
Eder Gambeta, Caio C Sestile, Manoela V Fogaça, Francisco S Guimarães, Elisabeth A Audi, Joice M da Cunha, Hélio Zangrossi, Paula Shimene de Melo Yamashita, Janaina M Zanoveli
It is known that diabetic (DBT) animals present dysregulation on the serotonergic system in several brain areas associated with anxiety-like responses. The aim of this study was to investigate the involvement of 5-HT1A receptors on dorsal periaqueductal gray (dPAG) in the behavioral response related to panic disorder in type-1 DBT animals. For this, the escape response by electric stimulation (ES) of dPAG in DBT and normoglycemic (NGL) animals was assessed. Both NGL and DBT animals were exposed to an open-field test (OFT) 28 days after DBT confirmation...
August 9, 2017: Behavioural Pharmacology
https://www.readbyqxmd.com/read/28767715/lafora-disease-in-miniature-wirehaired-dachshunds
#4
Lindsay Swain, Gill Key, Anna Tauro, Saija Ahonen, Peixiang Wang, Cameron Ackerley, Berge A Minassian, Clare Rusbridge
Lafora disease (LD) is an autosomal recessive late onset, progressive myoclonic epilepsy with a high prevalence in the miniature Wirehaired Dachshund. The disease is due to a mutation in the Epm2b gene which results in intracellular accumulation of abnormal glycogen (Lafora bodies). Recent breed-wide testing suggests that the carrier plus affected rate may be as high as 20%. A characteristic feature of the disease is spontaneous and reflex myoclonus; however clinical signs and disease progression are not well described...
2017: PloS One
https://www.readbyqxmd.com/read/28766469/the-forsaking-of-the-clinical-eeg-by-psychiatry-how-justified
#5
Nash N Boutros
Despite decades of publications attesting to the role of the clinical EEG in diagnosing and managing psychiatric disorders, the procedure remains highly underutilized in the practice of psychiatry. The visually inspected EEG (vEEG) can detect various forms of abnormalities, each with its own clinical significance. Abnormalities can be paroxysmal (i.e., suggestive of an epileptic-like process) or stationary. The most important unanswered question remains the value of detecting epileptiform activity in a nonepileptic psychiatric patient in predicting favorable responses to anticonvulsant treatment...
August 2, 2017: CNS Spectrums
https://www.readbyqxmd.com/read/28763736/schizophrenia-dissection-by-five-anxiety-and-depressive-subtype-comorbidities-clinical-implications-and-evolutionary-perspective
#6
André B Veras, Simone Cougo, Fernanda Meira, Clayton Peixoto, Jorge A Barros, Antonio E Nardi, Dolores Malaspina, Michael Poyurovsky, Jeffrey P Kahn
Twenty patients with DSM5 schizophrenia were comprehensively and formally assessed by an experienced psychiatrist. All subjects were assessed for: positive and negative psychotic symptoms; social anxiety; panic anxiety; obsessive compulsive disorder, atypical depression; major depression; suicide risk; and global assessment of functioning. Different profiles of clinical presentation and symptom evolution emerged for patients with schizophrenia who had co-morbid depression (15%), OCD (15%), panic or limited symptom attacks (55%) and social anxiety (5%)...
July 26, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28761695/misinterpretation-of-the-borg-s-rating-of-perceived-exertion-scale-by-patients-with-panic-disorder-during-ergospirometry-challenge
#7
Ricardo William Muotri, Marcio Antonini Bernik, Francisco Lotufo Neto
INTRODUCTION: The most widely used instrument to measure perceived exertion or exercise intensity is the Borg's Rating of Perceived Exertion (RPE) Scale. Panic attacks are aversive experiences that may be triggered by bodily sensations such as palpitations, breathlessness or dizziness due to increasing autonomic distress, prior sensitisation to panic and fear conditioning. The consequence is catastrophic interpretation of bodily sensations of arousal in general, which can lead to misinterpretation of exertion or exercise intensity...
2017: BMJ Open Sport & Exercise Medicine
https://www.readbyqxmd.com/read/28755568/what-patients-think-about-psychogenic-nonepileptic-seizures-in-buenos-aires-argentina-a-qualitative-approach
#8
Mercedes Sarudiansky, Alejandra Inés Lanzillotti, María Marta Areco Pico, Cristina Tenreyro, Laura Scévola, Silvia Kochen, Luciana D'Alessio, Guido Pablo Korman
PURPOSE: To analyse the methods of reasoning with regard to patients' experiences of living with psychogenic nonepileptic seizures (PNES) in Buenos Aires, Argentina. METHOD: A qualitative approach using semi-structured interviews was used to gain an in-depth and contextual understanding of the perspectives of five patients with PNES. Data collection and analysis were followed by an inductive and interpretive approach informed by the principles of thematic analysis...
July 20, 2017: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/28736332/5-hydroxytryptamine-2a-receptors-of-the-dorsal-raphe-nucleus-mediate-panic-like-behaviours-and-fear-induced-antinociception-elicited-by-neuronal-activation-in-the-central-nucleus-of-the-inferior-colliculus
#9
Raimundo da Silva Soares, Luiz Luciano Falconi-Sobrinho, Tayllon Dos Anjos-Garcia, Norberto Cysne Coimbra
It has been established that chemical stimulation of the inferior colliculus (IC) of laboratory animals evokes fear-related defensive responses, which are considered panic attack-like behaviours. In addition, there is evidence that defensive reactions provoked by chemical stimulation of midbrain tectum neurons may induce an antinociceptive response. Morphologically, the IC receives projections from other mesencephalic structures, such as the dorsal raphe nucleus (DRN), a region rich in serotonergic neurons that play a critical role in the control of defensive behaviours...
July 20, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/28667086/suitable-support-for-anxious-hospice-patients-what-do-nurses-know-do-and-need-an-explanatory-mixed-method-study
#10
Danielle Zweers, Everlien de Graaf, Saskia Teunissen
OBJECTIVE: To provide insight into what nurses know, do and need to provide support to anxious patients in hospice care (HC). METHODS: A mixed method study consisted of an online survey and focus groups (FGs) about what nurses know, do, and need was conducted. 336 HC nurses were invited to participate. Descriptive statistics were computed using SPSS. The χ(2) and t-tests were conducted to compare. The FGs were transcribed verbatim and thematically analysed. RESULTS: The survey was completed by 265 nurses (79%), and five FGs (n=25) were conducted...
June 30, 2017: BMJ Supportive & Palliative Care
https://www.readbyqxmd.com/read/28659126/paroxysmal-freezing-of-gait-in-a-patient-with-mesial-frontal-transient-ischemic-attacks
#11
Hee Won Hwang, Seung Ha Lee, Chul Hyoung Lyoo, Myung Sik Lee
BACKGROUND: Rare patients have been reported who developed a mixture of gait disturbances following a focal lesion in the frontal lobe. Thus, the exact location of frontal lesion responsible for a specific gait disturbance is not well defined. CASE PRESENTATION: We describe a 47-year-old man who experienced two episodes of paroxysmal freezing of gait of the right leg. During the attacks, he had no motor weakness, sensory change, or disequilibrium. He had past history of panic attacks...
June 28, 2017: BMC Neurology
https://www.readbyqxmd.com/read/28649201/evaluation-of-jnj-54717793-a-novel-brain-penetrant-selective-orexin-1-receptor-antagonist-in-two-rat-models-of-panic-attack-provocation
#12
Pascal Bonaventure, Christine Dugovic, Brock Shireman, Cathy Preville, Sujin Yun, Brian Lord, Diane Nepomuceno, Michelle Wennerholm, Timothy Lovenberg, Nicolas Carruthers, Stephanie D Fitz, Anantha Shekhar, Philip L Johnson
Orexin neurons originating in the perifornical and lateral hypothalamic area are highly reactive to anxiogenic stimuli and have strong projections to anxiety and panic-associated circuitry. Recent studies support a role for the orexin system and in particular the orexin 1 receptor (OX1R) in coordinating an integrative stress response. However, no selective OX1R antagonist has been systematically tested in two preclinical models of using panicogenic stimuli that induce panic attack in the majority of people with panic disorder, namely an acute hypercapnia-panic provocation model and a model involving chronic inhibition of GABA synthesis in the perifornical hypothalamic area followed by intravenous sodium lactate infusion...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28610672/agoraphobic-avoidance-predicts-emotional-distress-and-increased-physical-concerns-in-chronic-obstructive-pulmonary-disease
#13
Pawel Holas, Jaroslaw Michałowski, Łukasz Gawęda, Joanna Domagała-Kulawik
BACKGROUND: Anxiety and panic attacks are more common in chronic obstructive pulmonary disease (COPD) than in the overall population. Individuals with panic attacks often attempt to avoid situations perceived as at risk of eliciting bodily sensations such as dyspnea, which paradoxically may lead to anxiety-related responsivity. Although there is some evidence that COPD individuals restrict their participation in various life activities because they fear that these may trigger breathlessness, little is known about agoraphobic avoidance and its impact on cognitions and emotional distress in this population...
July 2017: Respiratory Medicine
https://www.readbyqxmd.com/read/28609307/a-6-year-posttreatment-follow-up-of-panic-disorder-patients-treatment-with-clonazepam-predicts-lower-recurrence-than-treatment-with-paroxetine
#14
Rafael C Freire, Roman Amrein, Marina D Mochcovitch, Gisele P Dias, Sergio Machado, Marcio Versiani, Oscar Arias-Carrión, Mauro G Carta, Antonio E Nardi
BACKGROUND: The aim of this study was to identify factors associated with relapse in panic disorder (PD). METHODS: This was an observational study conducted in the outpatient clinic of a psychiatric hospital in Rio de Janeiro, Brazil. In a previous study, 120 patients diagnosed as having PD according to Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition criteria were randomized to receive clonazepam or paroxetine. After 3 years, treatment was discontinued in patients who had achieved remission...
August 2017: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/28598929/association-of-job-stressors-with-panic-attack-and-panic-disorder-in-a-working-population-in-japan-a-cross-sectional-study
#15
Yumi Asai, Kotaro Imamura, Norito Kawakami
OBJECTIVE: This study aimed to investigate associations of job stressors with panic attack (PA) and panic disorder (PD) among Japanese workers. METHODS: A cross-sectional online questionnaire survey was conducted of 2060 workers. Job strain, effort/reward imbalance, and workplace social support were measured by the job content questionnaire and effort/reward imbalance questionnaire. These variables were classified into tertiles. PA/PD were measured by self-report based on the mini international neuropsychiatric interview (MINI)...
June 2017: Journal of Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/28583050/%C3%AE-opioid-and-5-ht1a-receptors-in-the-dorsomedial-hypothalamus-interact-for-the-regulation-of-panic-related-defensive-responses
#16
Camila Marroni Roncon, Paula Shimene de Melo Yamashita, Alana Tercino Frias, Elisabeth Aparecida Audi, Frederico Guilherme Graeff, Norberto Cysne Coimbra, Helio Zangrossi
The dorsomedial hypothalamus (DMH) and the dorsal periaqueductal gray (DPAG) have been implicated in the genesis and regulation of panic-related defensive behaviors, such as escape. Previous results point to an interaction between serotonergic and opioidergic systems within the DPAG to inhibit escape, involving µ-opioid and 5-HT1A receptors (5-HT1AR). In the present study we explore this interaction in the DMH, using escape elicited by electrical stimulation of this area as a panic attack index. The obtained results show that intra-DMH administration of the non-selective opioid receptor antagonist naloxone (0...
June 2017: Journal of Psychopharmacology
https://www.readbyqxmd.com/read/28551488/associations-of-plasma-leptin-to-clinical-manifestations-in-reproductive-aged-female-patients-with-panic-disorder
#17
Vasilios G Masdrakis, Charalambos Papageorgiou, Manolis Markianos
Preclinical studies suggest the implication of the adipocyte hormone leptin in anxiety and fear processes. We explored for potential differences regarding plasma leptin, cortisol and the ratio leptin/Body Mass Index (BMI) between 27 medication-free female patients with Panic Disorder (PD) and 42 age-matched female controls, and for potential associations between plasma leptin and psychometric evaluations including number of panic attacks during last week, Clinical Global Impression-Severity of Illness (CGI-S) and Symptoms Checklist-90-Revised (SCL-90-R)...
September 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28520662/anxiety-disorders-in-adults-with-childhood-traumatic-brain-injury-evidence-of-difficulties-more-than-10-years-postinjury
#18
Michelle Albicini, Audrey McKinlay
OBJECTIVE: To explore long-term psychiatric outcomes in individuals with a history of childhood traumatic brain injury (TBI) or orthopedic injury (OI). SETTING: Hospital emergency department, medical admission records and outpatient settings. PARTICIPANTS: There were 95 males (M = 22.78 years, SD = 3.44 years) and 74 females (M = 22.27 years, SD = 3.09 years), 65 with mild TBI (M = 23.25 years, SD = 3.58 years), 61 with moderate-severe TBI (M = 22...
May 17, 2017: Journal of Head Trauma Rehabilitation
https://www.readbyqxmd.com/read/28485259/distinct-phasic-and-sustained-brain-responses-and-connectivity-of-amygdala-and-bed-nucleus-of-the-stria-terminalis-during-threat-anticipation-in-panic-disorder
#19
L Brinkmann, C Buff, K Feldker, S V Tupak, M P I Becker, M J Herrmann, T Straube
BACKGROUND: Panic disorder (PD) patients are constantly concerned about future panic attacks and exhibit general hypersensitivity to unpredictable threat. We aimed to reveal phasic and sustained brain responses and functional connectivity of the amygdala and the bed nucleus of the stria terminalis (BNST) during threat anticipation in PD. METHODS: Using functional magnetic resonance imaging (fMRI), we investigated 17 PD patients and 19 healthy controls (HC) during anticipation of temporally unpredictable aversive and neutral sounds...
May 9, 2017: Psychological Medicine
https://www.readbyqxmd.com/read/28470168/anxiety-disorders
#20
REVIEW
Michelle G Craske, Murray B Stein, Thalia C Eley, Mohammed R Milad, Andrew Holmes, Ronald M Rapee, Hans-Ulrich Wittchen
Anxiety disorders constitute the largest group of mental disorders in most western societies and are a leading cause of disability. The essential features of anxiety disorders are excessive and enduring fear, anxiety or avoidance of perceived threats, and can also include panic attacks. Although the neurobiology of individual anxiety disorders is largely unknown, some generalizations have been identified for most disorders, such as alterations in the limbic system, dysfunction of the hypothalamic-pituitary-adrenal axis and genetic factors...
May 4, 2017: Nature Reviews. Disease Primers
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