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https://www.readbyqxmd.com/read/29884283/dynamics-of-defensive-response-mobilization-to-approaching-external-versus-interoceptive-threat
#1
Elischa Krause, Christoph Benke, Julian Koenig, Julian F Thayer, Alfons O Hamm, Christiane A Pané-Farré
BACKGROUND: Excessive fear and anxiety are core features of anxiety disorders. Defensive response mobilization varies dynamically with threat proximity. METHODS: We analyzed defensive responses in 48 healthy students to an approaching external, predator-like threat (an electric shock resembling a predator attack) versus an approaching threat from inside the body (feeling of dyspnea as evoked by forced breath-holding). Threats either were inevitable or could be avoided by button press...
June 2018: Biological Psychiatry: Cognitive Neuroscience and Neuroimaging
https://www.readbyqxmd.com/read/29865933/complex-regional-pain-syndrome-type-1-in-the-medico-legal-setting-high-rates-of-somatoform-disorders-opiate-use-and-diagnostic-uncertainty
#2
Christopher Bass, Gregory Yates
Objective The aim of this study was to review demographic and clinical characteristics of patients with complex regional pain syndrome type 1 (CRPS) seen in a UK medico-legal setting - particularly the relationship between CRPS and somatoform disorders. Methods Fifty consecutive cases of CRPS (interviewed 2005-2016) undergoing psychiatric assessment were reviewed. A systematic assessment of mental states was conducted via interview and examination of medical/psychiatric records. Thirty patients also completed the Brief Illness Perception Questionnaire (BIPQ)...
January 1, 2018: Medicine, Science, and the Law
https://www.readbyqxmd.com/read/29863695/-the-features-of-psychopharmacotherapy-of-depressive-states-with-panic-attacks
#3
N N Ivanets, M A Kinkulkina, K M Tartynskiy, G L Krenkel
AIM: To develop therapeutic programs for treatment of depression with panic attacks on the basis of their clinical and psychopathological features. MATERIAL AND METHODS: A total of 100 in- and outpatients, aged from 18 to 60 years, with depression of mild and moderate severity with panic attacks were studied. The investigation was carried out using clinical, psychopathological and psychometric (the Atypical Depression Diagnostic Scale (ADDS), the Montgomery-Asberg Depression Rating Scales (MADRS), and the Sheehan Anxiety Rating Scale (ShARS)) methods...
2018: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
https://www.readbyqxmd.com/read/29862830/brief-therapist-guided-exposure-treatment-of-panic-attacks-a-pilot-study
#4
Christina Bergmark Hall, Lars-Gunnar Lundh
A three-session therapist-guided exposure treatment was tested in a consecutive series of eight primary health care patients suffering from panic attacks who specifically used distraction techniques as their primary safety behavior. The Panic Disorder Severity Scale Self-Report (PDSS-SR) was administered at baseline (1-3 weeks before the first session), and 1, 2, and 3 weeks after treatment. Weekly ratings on the Body Sensations Questionnaire (BSQ) and the Agoraphobic Cognitions Questionnaire (ACQ) during treatment were undertaken to explore when reliable change took place on these measures...
June 1, 2018: Behavior Modification
https://www.readbyqxmd.com/read/29843260/is-breast-best-examining-the-effects-of-alcohol-and-cannabis-use-during-lactation
#5
R A Brown, H Dakkak, J A Seabrook
Maternal drug use during lactation may have adverse effects on the health of their children. Two common drugs used during this period are alcohol and cannabis. A literature search was conducted using PubMed, CINAHL, Nursing and Allied Health, and Google Scholar with the following search terms: marijuana, cannabis, THC, alcohol, ethanol, breastfeeding, lactation, and breastmilk. The search strategy was restricted to papers since the year 2000, and limited to English language journals. Reference lists were also used to capture any articles that were missed from the database searches...
May 23, 2018: Journal of Neonatal-perinatal Medicine
https://www.readbyqxmd.com/read/29787922/the-association-of-panic-and-hyperventilation-with-psychogenic-non-epileptic-seizures-a-systematic-review-and-meta-analysis
#6
REVIEW
Alaric M Indranada, Saul A Mullen, Roderick Duncan, David J Berlowitz, Richard A A Kanaan
INTRODUCTION: Psychogenic Non-Epileptic Seizures (PNES) are events that appear epileptic but are instead thought to have a psychological origin. Increased rates of several psychiatric disorders have been reported in PNES, including anxiety and panic disorders. Some theories suggest panic and/or hyperventilation have aetiological roles in PNES, though these remain unproven. METHODS: We conducted a systematic review of associations of panic and hyperventilation with PNES using Ovid Medline and PubMed, and a meta-analysis where appropriate...
May 19, 2018: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/29785475/cohort-study-of-psychiatric-adverse-events-following-exposure-to-levonorgestrel-containing-intrauterine-devices-in-uk-general-practice
#7
Jim Slattery, Daniel Morales, Luis Pinheiro, Xavier Kurz
INTRODUCTION: Intrauterine devices are implantable contraceptives of which some brands steadily release levonorgestrel over an extended time period. Exposure to a levonorgestrel-releasing intrauterine device has been associated with depression and, more recently, a connection to anxiety, panic attacks, sleep problems and restlessness has been suggested. This study uses data from the THIN database of UK general practice to investigate these suggestions. METHODS: A cohort study was performed to compare the incidence of psychiatric adverse events between groups of women who were new users of levonorgestrel-releasing and non-hormonal intrauterine devices...
May 21, 2018: Drug Safety: An International Journal of Medical Toxicology and Drug Experience
https://www.readbyqxmd.com/read/29760763/an-open-label-flexible-dose-adaptive-study-evaluating-the-efficacy-of-vortioxetine-in-subjects-with-panic-disorder
#8
Anish Shah, Joanne Northcutt
Background: Despite the current treatments available for panic disorder (PD), as many as one-third of patients have persistent and treatment-resistant panic attacks. Vortioxetine is an approved medicine for major depressive disorder and has been shown to have anxiolytic properties. The purpose of this study was to evaluate its efficacy and safety in an adult population with a diagnosis of PD. Methods: The study design was open label with flexible dose strategies (5, 10, or 20 mg) with a treatment period of 10 weeks...
2018: Annals of General Psychiatry
https://www.readbyqxmd.com/read/29737230/the-nitric-oxide-donor-sin-1-produced-panic-like-behaviour-and-fear-induced-antinociception-are-modulated-by-nmda-receptors-in-the-anterior-hypothalamus
#9
Luiz Luciano Falconi-Sobrinho, Norberto Cysne Coimbra
BACKGROUND: An excitatory imbalance in the hypothalamus of rodents caused by local chemical stimulation elicits fear-related defensive reactions such as escape and freezing. In addition, these panic attack-like defensive reactions induced by hypothalamic neurons may cause antinociception. However, there is a shortage of studies showing the participation of the anterior hypothalamic nucleus in these adaptive defensive mechanisms. Nitric oxide (NO) donors have been shown to evoke fear-related defensive responses when microinjected into paralimbic and limbic structures, and this excitatory neuromodulation can recruit the glutamatergic system...
April 1, 2018: Journal of Psychopharmacology
https://www.readbyqxmd.com/read/29680728/respiratory-subtype-of-panic-disorder-can-serum-phosphate-levels-be-a-possible-outcome-to-group-cognitive-behavior-therapy
#10
Pedro Beria, Ana Cristina W Viana, Andressa Behenck, Elizeth Heldt, Gisele Gus Manfro, Carolina Blaya Dreher
OBJECTIVE: Panic disorder (PD) respiratory subtype (RS) was described in order to cluster patients according to their symptoms. These patients are characterized by experiencing a relatively high number of noticeable respiratory symptoms during a panic attack (PA) and a higher reactivity to CO2 . In this study, we aimed to evaluate the clinical relevance of this diagnostic category, evaluating if there are different responses to cognitive-behavioral therapy in patients with panic disorder RS as compared to those with the non-respiratory subtype (NRS), using serum phosphate as a biological marker...
August 1, 2018: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29678310/grossly-abnormal-ventilation-perfusion-spect-study-in-idiopathic-pulmonary-arterial-hypertension-without-thromboembolism
#11
Kenneth Chan, John G Coghlan, Margaret Hall, Jamanda Haddock, Alan Bates, Benjamin E Schreiber
Pulmonary hypertension is a serious condition with multiple underlying aetiologies which require different treatment strategies. We present a case of severe idiopathic pulmonary arterial hypertension in a 20-year-old patient with ongoing breathlessness. She was initially diagnosed with asthma and panic attacks in community care. As the symptoms became progressively worse, she was referred for pulmonary hypertension clinic assessment. Ventilation/perfusion single-photon emission computed tomography (V/Q SPECT) showed grossly abnormal perfusion defects which were mismatched to the ventilation scan, suggestive of chronic thromboembolic disease...
January 31, 2018: Heart, Lung & Circulation
https://www.readbyqxmd.com/read/29659102/initial-severity-and-antidepressant-efficacy-for-anxiety-disorders-obsessive-compulsive-disorder-and-posttraumatic-stress-disorder-an-individual-patient-data-meta-analysis
#12
Ymkje Anna de Vries, Annelieke M Roest, Johannes G M Burgerhof, Peter de Jonge
BACKGROUND: It has been suggested that antidepressant benefits are smaller for mild than severe depression. Because antidepressants are also used for anxiety disorders, obsessive-compulsive disorder (OCD), and posttraumatic stress disorder (PTSD), we examined the influence of severity for these disorders. METHODS: We used individual patient data of eight trials (3,430 participants) for generalized anxiety disorder (GAD); four trials (1,195 participants) for social anxiety disorder (SAD); four trials (1,132 participants) for OCD; three trials (1,071 participants) for PTSD; and 10 trials (2,151 participants) for panic disorder (PD)...
June 2018: Depression and Anxiety
https://www.readbyqxmd.com/read/29652305/-efficiency-of-neuromultivit-in-complex-therapy-of-patients-with-rheumatoid-arthritis-associated-with-diabetes-mellitus
#13
L N Eliseeva, A Yu Selimov, A Yu Blednova, Zh Z Otarova, M I Bocharnikova, V S Seredinsky
AIM: To examine the dysregulation of the autonomic nervous system and manifestations of pain syndrome in patients with rheumatoid arthritis combined with diabetes mellitus and the possibility of their correction in patients who receive complex therapy including neurotropic vitamins (neuromultivitis). MATERIAL AND METHODS: One hundred and forty-six patients with rheumatoid disease were examined including 59 patients with diabetes mellitus. RESULTS AND CONCLUSION: When testing for the presence of neuropathic pain syndrome using the diagnostic questionnaire of neuropathic pain (DN4), a greater prevalence of these features was revealed, with a high correlation with the duration of rheumatoid arthritis (r=0,56) and duration of diabetes mellitus (r=0,82)...
2018: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
https://www.readbyqxmd.com/read/29644077/unusual-presentation-of-pheochromocytoma-thirteen-years-of-anxiety-requiring-psychiatric-treatment
#14
Catherine Alguire, Jessica Chbat, Isabelle Forest, Ariane Godbout, Isabelle Bourdeau
Pheochromocytoma is a rare tumor of the adrenal gland. It often presents with the classic triad of headache, palpitations and generalized sweating. Although not described as a typical symptom of pheochromocytoma, anxiety is the fourth most common symptom reported by patients suffering of pheochromocytoma. We report the case of a 64 year old man who had severe anxiety and panic disorder as presenting symptoms of pheochromocytoma. After 13 years of psychiatric follow-up, the patient was diagnosed with malignant pheochromocytoma...
2018: Endocrinology, Diabetes & Metabolism Case Reports
https://www.readbyqxmd.com/read/29623195/is-panic-disorder-a-disorder-of-physical-fitness-a-heuristic-proposal
#15
REVIEW
Giampaolo Perna, Daniela Caldirola
Currently, panic disorder (PD) is considered a mental disorder based on the assumptions that panic attacks (PAs) are "false alarms" that arise from abnormally sensitive defense systems in the central nervous system and that PD is treated with therapies specifically acting on anxiety or fear mechanisms. This article aims to propose an alternative perspective based on the results of some experimental studies. Our heuristic proposal suggests not only that PD may be a mental disorder but also that patients with PD have real abnormal body functioning, mainly involving cardiorespiratory and balance systems, leading to a decline in global physical fitness...
2018: F1000Research
https://www.readbyqxmd.com/read/29620793/antidepressants-versus-placebo-for-panic-disorder-in-adults
#16
REVIEW
Irene Bighelli, Mariasole Castellazzi, Andrea Cipriani, Francesca Girlanda, Giuseppe Guaiana, Markus Koesters, Giulia Turrini, Toshi A Furukawa, Corrado Barbui
BACKGROUND: Panic disorder is characterised by repeated, unexpected panic attacks, which represent a discrete period of fear or anxiety that has a rapid onset, reaches a peak within 10 minutes, and in which at least four of 13 characteristic symptoms are experienced, including racing heart, chest pain, sweating, shaking, dizziness, flushing, stomach churning, faintness and breathlessness. It is common in the general population with a lifetime prevalence of 1% to 4%. The treatment of panic disorder includes psychological and pharmacological interventions...
April 5, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29602786/sensitive-and-specific-recombinase-polymerase-amplification-assays-for-fast-screening-detection-and-identification-of-bacillus-anthracis-in-a-field-setting
#17
Mostafa Bentahir, Jérôme Ambroise, Cathy Delcorps, Paola Pilo, Jean-Luc Gala
Four isothermal recombinase polymerase amplification (RPA) assays were developed for fast in-field identification of Bacillus anthracis The RPA assays targeted three specific sequences (i.e., the BA_5345 chromosomal marker, the lethal factor lef [from pXO1], and the capsule-biosynthesis-related capA [from pXO2]) and a conserved sequence in the adenylate cyclase gene ( adk ) for the Bacillus cereus group. B. anthracis -specific RPA assays were tested first with purified genomic DNAs ( n = 60), including 11 representatives of B...
June 1, 2018: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/29574383/interplay-between-comt-val158met-childhood-adversities-and-sex-in-predicting-panic-pathology-findings-from-a-general-population-sample
#18
Eva Asselmann, Johannes Hertel, Katja Beesdo-Baum, Carsten-Oliver Schmidt, Georg Homuth, Matthias Nauck, Hans-Jörgen Grabe, Christiane A Pané-Farré
BACKGROUND: The single nucleotide polymorphism rs4680 of the catechol-O-methyltransferase (COMT) gene has been implicated to be involved in the etiopathogenesis of panic. However, it remains unresolved whether rs4680 modifies the risk-association between early life stress and subsequent development of panic pathology. METHODS: The genotype of rs4680 was determined for n = 2242 adults with European ancestry from the Study of Health in Pomerania (SHIP, a regional longitudinal cohort study from northeastern Germany)...
July 2018: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29542033/patients-perspective-of-the-impact-of-copd-on-quality-of-life-a-focus-group-study-for-patients-with-copd
#19
Anan Jarab, Eman Alefishat, Tareq Mukattash, Karem Alzoubi, Sharrel Pinto
Background The quality of life has been shown to be poor in patients with chronic obstructive pulmonary disease (COPD). Furthermore, patients' perspective and attitudes toward COPD and its impact on their quality of life have been remarkably ignored. Objective To explore patients' views and perceptions regarding COPD and its impact on their quality of life. Setting COPD clinic at the Royal Medical Services Hospital, Amman, Jordan. Method Focus groups discussions to explore patients' views and perceptions about COPD were conducted using purposive sampling technique till data saturation achieved...
March 14, 2018: International Journal of Clinical Pharmacy
https://www.readbyqxmd.com/read/29482044/screening-for-panic-related-anxiety-in-emergency-department-patients-with-cardiopulmonary-complaints-a-comparison-of-two-self-report-instruments
#20
Sharon C Sung, Jackie Ma, Arul Earnest, A John Rush, Leslie E C Lim, Marcus E H Ong
The present study examined 1) the accuracy of two self-report measures for detecting panic-related anxiety in emergency department (ED) patients with cardiopulmonary complaints; and 2) whether modified scoring resulted in improved performance. English-speaking adults presenting to the ED of a large public hospital with palpitations, chest pain, dizziness, or difficulty breathing were evaluated for the presence of panic-related anxiety with the Structured Clinical Interview for DSM-IV (SCID) over a one-year period...
May 2018: Psychiatry Research
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