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HDL Proteomics

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https://www.readbyqxmd.com/read/29888289/haptoglobin-genotype-is-a-determinant-of-hemoglobin-adducts-and-vitamin-e-content-in-hdl
#1
Hagit Goldenstein, Nina S Levy, John Ward, Tina Costacou, Andrew P Levy
Haptoglobin (Hp) is an abundant hemoglobin- (Hb-) binding serum protein and a constituent of the HDL proteome. In man, there exists a common polymorphism at the Hp locus with two common alleles defined by the presence (Hp 2 allele) or absence (Hp 1 allele) of a 1.7 kb in-frame partial duplication of exons 3 and 4 of the Hp gene. Numerous studies have demonstrated that the Hp 2-2 genotype is associated with a 3-5-fold increase in vascular disease among individuals with diabetes mellitus (DM). Increased Hp-Hb complex has been shown to be associated with the HDL of Hp 2-2 DM individuals...
2018: Journal of Diabetes Research
https://www.readbyqxmd.com/read/29886354/remodeling-of-the-hdl-proteome-with-treatment-response-to-abatacept-or-adalimumab-in-the-ample-trial-of-patients-with-rheumatoid-arthritis
#2
C Charles-Schoeman, G B Gugiu, H Ge, A Shahbazian, Y Y Lee, X Wang, D E Furst, V K Ranganath, M Maldonado, Terry Lee, S T Reddy
BACKGROUND AND AIMS: To evaluate changes in the high-density lipoprotein (HDL) proteome and HDL function in active rheumatoid arthritis (RA) patients initiating therapy with abatacept or adalimumab in the Abatacept Versus Adalimumab Comparison in Biologic-Naïve RA Subjects with Background Methotrexate (AMPLE) study. METHODS: Ultra high-pressure liquid chromatography (UHPLC) coupled with ion mobility mass spectrometry (LC-IM-MS) was used to analyze proteins associated with immunoaffinity-captured HDL from plasma of 30 patients with RA randomized to either abatacept (n = 15) or adalimumab (n = 15) therapy...
April 17, 2018: Atherosclerosis
https://www.readbyqxmd.com/read/29879989/protein-markers-of-dysfunctional-hdl-in-scavenger-receptor-class-b-type-i-deficient-mice
#3
Jia Cao, Yanyong Xu, Feifei Li, Liang Shang, Daping Fan, Hong Yu
BACKGROUND: Scavenger receptor class B type I (SR-BI) plays a key role in high density lipoproteins (HDL) metabolism. SR-BI deficiency in mice results in enhanced susceptibility to atherosclerosis with abnormal large, cholesterol enriched, and functional impaired HDL. This study was to characterize the protein markers of dysfunctional HDL in SR-BI deficient (SR-BI-/- ) mice and to test if the defective of HDL might be affected by probucol treatment. METHODS: Shotgun proteomics and 2-D gel electrophoresis were performed to examine the profile of HDL protein and distribution of HDL particles isolated from SR-BI-/- mice...
June 7, 2018: Journal of Translational Medicine
https://www.readbyqxmd.com/read/29782274/-dysfunctional-high-density-lipoproteins-role-in-atherogenesis-and-potential-targets-for-phospholipid-therapy
#4
T I Torchovskaya, V A Kudinov, T S Zakharova, S S Markin
In recent years the number of articles on damages of high-density lipoproteins (HDL) properties in patients with atherosclerosis has sharply increased. First, it concerns their ability to accept cholesterol (CH) from macrophages - the basis of antiatherogenic action of HDL. This ability was assessed ex vivo - by activity of cell cholesterol (CH) efflux to HDL or into patient's serum. In many works inverse relationship was shown between CH acceptor capacity of HDL and severity of atherosclerotic disease or frequency of its exacerbations during long-term observation, independent from HDL CH concentration...
March 2018: Kardiologiia
https://www.readbyqxmd.com/read/29772557/high-density-lipoprotein-carbamylation-and-dysfunction-in-vascular-disease
#5
Jeans Miguel Santana, Clinton Douglas Brown
High-density lipoprotein (HDL) is cardioprotective because of its anti-atherogenic properties. Nevertheless, our goal to optimize HDL cholesterol (HDL-C) levels have had little effects on the atherothrombotic burden and suggests a closer look be taken at HDL function and dysfunction. HDL is a group of complex macromolecules composed of a lipid- and proteome that work in synergy to execute its anti-inflammatory, anti-atherogenic, and anti-thrombotic effects. However, throughout its life-span in circulation, HDL undergoes significant modification...
June 1, 2018: Frontiers in Bioscience (Landmark Edition)
https://www.readbyqxmd.com/read/29744368/identification-of-potential-therapeutic-targets-in-the-liver-of-pioglitazone-treated-type-2-diabetes-sprague-dawley-rats-via-expression-profile-chip-and-itraq-assay
#6
Zhong-Xia Lu, Wen-Jun Xu, Yang-Sheng Wu, Chang-Yu Li, Yi-Tao Chen
The aim of the present study was to identify key antidiabetic nodes in the livers of pioglitazone-treated type 2 diabetes mellitus Sprague-Dawley rats by transcriptomic and proteomic analysis. Rats were randomly divided into the control, the diabetes model, and the pioglitazone-treated groups. After treatment with pioglitazone for 11 weeks, the effects on fasting blood glucose, body weight, and blood biochemistry parameters were evaluated. Microarray and iTRAQ analysis were used to determine the differentially expressed genes/proteins in rat livers...
2018: Journal of Diabetes Research
https://www.readbyqxmd.com/read/29699812/a-short-term-increase-in-dietary-cholesterol-and-fat-intake-affects-high-density-lipoprotein-composition-in-healthy-subjects
#7
C Morgantini, S Trifirò, D Tricò, D Meriwether, S Baldi, A Mengozzi, S T Reddy, A Natali
BACKGROUND AND AIMS: High-cholesterol and high-fat diets alter biochemical composition and anti-oxidant properties of high-density lipoproteins (HDL) in animals. Whether this occurs in humans is unknown. Therefore, we examined the effect of a short-term elevation in dietary cholesterol and fat intake on HDL composition in healthy subjects. METHODS AND RESULTS: In a randomized, crossover clinical trial, 14 healthy young volunteers followed a 14-day low-cholesterol/low-fat diet (LChF) and a 14-day isocaloric high-cholesterol/high-fat diet (HChF) in a random order...
June 2018: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
https://www.readbyqxmd.com/read/29649363/a-targeted-differential-top-down-proteomic-methodology-for-comparison-of-apoa-i-proteoforms-in-individuals-with-high-and-low-hdl-efflux-capacity
#8
Henrique Dos Santos Seckler, Luca Fornelli, R Kannan Mutharasan, C Shad Thaxton, Ryan Fellers, Martha Daviglus, Allan Sniderman, Daniel Rader, Neil L Kelleher, Donald M Lloyd-Jones, Philip D Compton, John T Wilkins
Top-down proteomics (TDP) allows precise determination/characterization of the different proteoforms derived from the expression of a single gene. In this study, we targeted apolipoprotein A-I (ApoA-I), a mediator of high-density-lipoprotein cholesterol efflux (HDL-E), which is inversely associated with coronary heart disease risk. Absolute ApoA-I concentration and allelic variation only partially explain interindividual HDL-E variation. Therefore, we hypothesize that differences in HDL-E are associated with the abundances of different ApoA-I proteoforms...
June 1, 2018: Journal of Proteome Research
https://www.readbyqxmd.com/read/29623821/long-term-effect-of-lysine-restriction-on-liver-global-proteins-meat-quality-and-blood-biochemical-parameters-in-pigs
#9
Zhaojin Liu, Yong Yuan, Jie Yin, Tiejun Li, Hongfu Zhang, Jianhua He
BACKGROUND: Our previous study suggested that short-term lysine restriction improved feed intake and gut microbiota in piglets. Thus, in this study, we further used proteomics technology to investigate the potential mechanism associated with long-term lysine restriction in pigs. In addition, blood biochemical parameters, meat quality, and muscle nutrient transporters were also investigated. RESULTS: The results showed that 131 proteins in the liver were markedly altered in response to dietary lysine restriction, with 54 being downregulated and 77 being upregulated, which mainly involved in neurodegenerative diseases, oxidative phosphorylation, and metabolic pathways...
April 6, 2018: Protein and Peptide Letters
https://www.readbyqxmd.com/read/29561322/hdls-and-the-pathogenesis-of-atherosclerosis
#10
Adel Schwertani, Hong Y Choi, Jacques Genest
PURPOSE OF REVIEW: Plasma levels of HDL cholesterol are a biomarker of cardiovascular health but not a therapeutic target, as demonstrated by the failure of pharmacological modulation of HDL cholesterol to prevent or treat atherosclerotic cardiovascular disease. In health, HDL particles exert pleiotropic effects against atherosclerosis, including cholesterol removal from foam cells, vasodilatory effects through vascular endothelial cell nitric oxide production, decreased vascular inflammation and oxidative damage, endothelial cell proliferation and antiapoptotic effects...
May 2018: Current Opinion in Cardiology
https://www.readbyqxmd.com/read/29527140/proteomic-characterization-of-high-density-lipoprotein-particles-in-patients-with-non-alcoholic-fatty-liver-disease
#11
Prahlad K Rao, Kate Merath, Eugene Drigalenko, Avinash Y L Jadhav, Richard A Komorowski, Matthew I Goldblatt, Anand Rohatgi, Mark A Sarzynski, Samer Gawrieh, Michael Olivier
Background: Metabolic diseases such as obesity and diabetes are associated with changes in high-density lipoprotein (HDL) particles, including changes in particle size and protein composition, often resulting in abnormal function. Recent studies suggested that patients with non-alcoholic fatty liver disease (NAFLD), including individuals with non-alcoholic steatohepatitis (NASH), have smaller HDL particles when compared to individuals without liver pathologies. However, no studies have investigated potential changes in HDL particle protein composition in patients with NAFLD, in addition to changes related to obesity, to explore putative functional changes of HDL which may increase the risk of cardiovascular complications...
2018: Clinical Proteomics
https://www.readbyqxmd.com/read/29505607/myeloperoxidase-mediated-hdl-oxidation-and-hdl-proteome-changes-do-not-contribute-to-dysfunctional-hdl-in-chinese-subjects-with-coronary-artery-disease
#12
Guisong Wang, Anna Vachaparampil Mathew, Haiyi Yu, Lei Li, Liyun He, Wei Gao, Xiaodan Liu, Yanhong Guo, Jaeman Byun, Jifeng Zhang, Y Eugene Chen, Subramaniam Pennathur
High density lipoprotein (HDL) cholesterol levels and cholesterol efflux capacity (CEC) are inversely correlated with coronary artery disease (CAD) risk. Myeloperoxidase (MPO) derived oxidants and HDL proteome changes are implicated in HDL dysfunction in subjects with CAD in the United States; however, the effect of MPO on HDL function and HDL proteome in ethnic Chinese population is unknown. We recruited four matched ethnic Chinese groups (20 patients each): subjects with 1) low HDL levels (HDL levels in men <40mg/dL and women <50mg/dL) and non-CAD (identified by coronary angiography or cardiac CT angiography); 2) low HDL and CAD; 3) high HDL (men >50mg/dL; women >60mg/dL) with no CAD; and 4) high HDL with CAD...
2018: PloS One
https://www.readbyqxmd.com/read/29411613/rapid-affinity-enrichment-of-human-apolipoprotein-a-i-associated-lipoproteins-for-proteome-analysis
#13
Timothy S Collier, Zhicheng Jin, Celalettin Topbas, Cory Bystrom
Isolation of high density lipoproteins (HDL) for structural and functional studies typically relies on ultracentrifugation techniques, which are time-consuming and difficult to scale. With emerging interest in the clinical relevance of HDL structure and function to cardiovascular disease, a significant gap exists between current and desirable sample preparation throughput. To enable proteomic studies of HDL with large clinical cohorts, we have developed an affinity enrichment approach that relies on the association of histidine-tagged, lipid free ApoA-I with HDL followed by standard metal chelate chromatography...
March 2, 2018: Journal of Proteome Research
https://www.readbyqxmd.com/read/29366287/lipidomic-and-proteomic-predictors-of-drastic-reductions-of-hdl-in-the-accord-lipid-trial
#14
Gissette Reyes-Soffer, Maryam Khavani, Stephen Holleran, Rajasekhar Ramakrishnan, Amy Lovato, Henry Ginsberg
No abstract text is available yet for this article.
August 2017: Atherosclerosis
https://www.readbyqxmd.com/read/29366071/shotgun-proteomics-analysis-characterizes-hdl-proteome-in-patients-with-cholesteryl-ester-transfer-protein-deficiency
#15
Takeshi Okada, Tohru Ohama, Kotaro Kanno, Hibiki Matsuda, Masami Sairyo, Yinghong Zhu, Ayami Saga, Takuya Kobayashi, Daisaku Masuda, Masahiro Koseki, Makoto Nishida, Yasushi Sakata, Shizuya Yamashita
No abstract text is available yet for this article.
August 2017: Atherosclerosis
https://www.readbyqxmd.com/read/29251807/proteomic-diversity-of-high-density-lipoprotein-explains-its-association-with-clinical-outcome-in-patients-with-heart-failure
#16
Johanna Elisabeth Emmens, Donald J L Jones, Thong H Cao, Daniel C S Chan, Simon P R Romaine, Paulene A Quinn, Stefan D Anker, John G Cleland, Kenneth Dickstein, Gerasimos Filippatos, Hans L Hillege, Chim C Lang, Piotr Ponikowski, Nilesh J Samani, Dirk J van Veldhuisen, Faiz Zannad, Aeilko H Zwinderman, Marco Metra, Rudolf A de Boer, Adriaan A Voors, Leong L Ng
AIMS: Previously, low high-density lipoprotein (HDL) cholesterol was found to be one of the strongest predictors of mortality and/or heart failure (HF) hospitalisation in patients with HF. We therefore performed in-depth investigation of the multifunctional HDL proteome to reveal underlying pathophysiological mechanisms explaining the association between HDL and clinical outcome. METHODS AND RESULTS: We selected a cohort of 90 HF patients with 1:1 cardiovascular death/survivor ratio from BIOSTAT-CHF...
February 2018: European Journal of Heart Failure
https://www.readbyqxmd.com/read/29226278/effects-of-multiple-freeze-thaw-cycles-on-measurements-of-potential-novel-biomarkers-associated-with-adverse-pregnancy-outcomes
#17
Sandra L Rebholz, John T Melchior, Jeffrey A Welge, Alan T Remaley, W Sean Davidson, Laura A Woollett
World-wide, millions of women enter preterm labor or have small newborns. Effective biomarkers are needed to identify women at risk for these adverse outcomes. A time and cost effective way to examine any potentially new biomarkers in samples collected during prior studies or trials that had been assayed for other metabolites would be highly useful. Thus, the current study aimed to determine if samples that had been previously thawed and re-frozen could be re-assayed for novel biomarkers, those being lipoprotein composition (sizing, proteome, lipids) and combined cholesterol and cytokine concentrations...
2017: Journal of Clinical and Laboratory Medicine
https://www.readbyqxmd.com/read/29149817/high-density-lipoprotein-hdl-dysfunction-and-future-of-hdl
#18
Sibel Ertek
Although high density lipoprotein cholesterol (HDL-C) levels are inversely proportional to cardiovascular risk in many studies, recent pharmacological interventional studies with HDL-C raising strategies did not show a benefit in terms of vascular events. The HDL particle is heterogenous with anti-atherogenic functions and non-vascular effects. Many factors affect HDL components and may either cause compositional changes, post-translational modifications of proteins, or alter lipids and other cargo molecules; generally these factors cause more than one of these changes, resulting in functional differences...
November 16, 2017: Current Vascular Pharmacology
https://www.readbyqxmd.com/read/29142235/proteomic-study-revealed-cellular-assembly-and-lipid-metabolism-dysregulation-in-sepsis-secondary-to-community-acquired-pneumonia
#19
Narendra Kumar Sharma, Alexandre Keiji Tashima, Milena Karina Colo Brunialti, Eden Ramalho Ferreira, Ricardo Jose Soares Torquato, Renato Arruda Mortara, Flavia Ribeiro Machado, Murillo Assuncao, Otelo Rigato, Reinaldo Salomao
Sepsis is a life-threatening disorder characterized by organ dysfunction and a major cause of mortality worldwide. The major challenge in studying sepsis is its diversity in such factors as age, source of infection and etiology. Recently, genomic and proteomic approaches have improved our understanding of its complex pathogenesis. In the present study, we use quantitative proteomics to evaluate the host proteome response in septic patients secondary to community-acquired pneumonia (CAP). Samples obtained at admission and after 7 days of follow-up were analyzed according to the outcomes of septic patients...
November 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29115584/apolipoprotein-c-iii-in-the-high-density-lipoprotein-proteome-of-cerebral-lacunar-infarction-patients-impairs-its-anti-inflammatory-function
#20
Pu Lv, Mingming Zhao, Yuanyuan Liu, Haiqiang Jin, Wei Cui, Chenghe Fan, Yuming Teng, Lemin Zheng, Yining Huang
High-density lipoprotein (HDL) proteomic study has identified substantial changes associated with various disease states. In the current study, the HDL proteomes in patients with cerebral lacunar infarction (LACI) and control subjects were investigated. A total of 12 LACI patients without evident large vessel occlusions and 12 controls were enrolled in the study. The HDL fraction from each sample was isolated from the plasma by ultracentrifugation. The protemics of the HDL were investigated using nano liquid chromatography coupled to tandem mass spectrometry...
January 2018: International Journal of Molecular Medicine
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