keyword
https://read.qxmd.com/read/38537153/novel-proteomic-signatures-may-indicate-mri-assessed-intrahepatic-fat-state-and-changes-the-direct-plus-clinical-trial
#1
JOURNAL ARTICLE
Dana T Goldberg, Anat Yaskolka Meir, Gal Tsaban, Ehud Rinott, Alon Kaplan, Hila Zelicha, Nora Klöting, Uta Ceglarek, Berend Iserman, Ilan Shelef, Philip Rosen, Matthias Blüher, Michael Stumvoll, Ohad Etzion, Meir J Stampfer, Frank B Hu, Iris Shai
OBJECTIVE: We demonstrated in the randomized 18-month DIRECT PLUS trial (n=294) that a Mediterranean (MED) diet, supplemented with polyphenol-rich Mankai duckweed, green tea, and walnuts and restricted in red/processed meat, caused substantial intrahepatic fat (IHF%) loss compared with two other healthy diets, reducing NAFLD by half, regardless similar weight loss. Here, we investigated the baseline proteomic profile associated with IHF% and the changes in proteomics associated with IHF% changes induced by lifestyle intervention...
March 27, 2024: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://read.qxmd.com/read/38536813/demography-commonly-diagnosed-disorders-and-mortality-of-guinea-pigs-under-primary-veterinary-care-in-the-uk-in-2019-a-vetcompass-study
#2
JOURNAL ARTICLE
Dan G O'Neill, Jacques L Taffinder, Dave C Brodbelt, Vicki Baldrey
INTRODUCTION: Guinea pigs are popular as domestic pets but there is limited information on the health of the wider pet population. This study aimed to report demography, commonly diagnosed disorders and mortality of guinea pigs under UK primary veterinary care. METHODS: Diagnosis and mortality information on guinea pigs was extracted from anonymised UK primary-care clinical records in VetCompass. RESULTS: From 51,622 guinea pigs under primary veterinary care during 2019, a specific breed was not recorded in 50,098 (97...
2024: PloS One
https://read.qxmd.com/read/38536125/overcoming-solubility-challenges-liposomal-isocoq-carbazole-as-a-promising-anti-tumor-agent-for-inoperable-and-radiation-insensitive-cancers
#3
JOURNAL ARTICLE
Diana Lamaa, Catherine Cailleau, Juliette Vergnaud, Julie Mougin, Jérôme Bignon, Mouad Alami, Elias Fattal, Abdallah Hamze, Nicolas Tsapis
This study evaluated the potential of isoCoQ-Carbazole, a diheterocyclic analog of isoCA-4, as an anti-tumor agent. To overcome its low aqueous solubility, liposomes were developed as a delivery system for the compound. In vitro experiments showed that loaded liposomes exhibited similar activity to the free form on multiple human tumor cell lines. In vivo experiments using a palliative intratumoral injection chemotherapy approach further demonstrated that isoCoQ-Carbazole loaded liposomes significantly reduced tumor growth in a CA-4-resistant HT29 cell model, without inducing any observable toxicity or weight loss in the treated mice...
March 27, 2024: Chembiochem: a European Journal of Chemical Biology
https://read.qxmd.com/read/38535464/algae-based-supplements-claiming-weight-loss-properties-authenticity-control-and-scientific-based-evidence-on-their-effectiveness
#4
JOURNAL ARTICLE
Fátima Fernandes, Raquel Martins, Mariana Barbosa, Patrícia Valentão
The worldwide prevalence of obesity impacts more than 600 million adults. Successfully managing weight is effective in reducing the risk of chronic diseases, but sustaining long-term weight loss remains a challenge. Although there are supplements based on algae that claim to aid in weight loss, there is a notable scarcity of scientific evidence supporting their effectiveness, and their regular consumption safety remains inadequately addressed. In this work, commercially available Arthrospira (Spirulina) platensis Gomont and/or Fucus vesiculosus L...
March 5, 2024: Marine Drugs
https://read.qxmd.com/read/38535205/comparative-transcriptome-analysis-explores-the-mechanism-of-angiosperm-and-gymnosperm-deadwood-degradation-by-fomes-fomentarius
#5
JOURNAL ARTICLE
Yulian Wei, Jianbin Xue, Jiangtao Shi, Tong Li, Haisheng Yuan
In forest ecosystems, most of the soil organic matter is derived from trees, as deadwood lignocellulose and wood-decaying basidiomycetes are the most important decomposers of lignin and cellulose. Fomes fomentarius is one of the most common white-rot fungi colonizing angiosperm trees and is often found in birch deadwood but seldom in pine deadwood. To reveal the mechanism through which F. fomentarius selects angiosperms as its preferred host trees, birch and pinewood sticks were selected for culturing for two months...
March 4, 2024: Journal of Fungi (Basel, Switzerland)
https://read.qxmd.com/read/38535172/ozone-application-suppressed-the-blue-mold-development-and-maintained-the-main-active-ingredients-content-of-postharvest-fresh-codonopsis-pilosula-during-storage
#6
JOURNAL ARTICLE
Jiangyang Chen, Zhiguang Liu, Qili Liu, Dan Zhang, Huali Xue, Suqin Shang, Yang Bi
Penicillium expansum is the predominant causal agent causing blue mold in postharvest fresh Codonopsis pilosula during storage. The pathogen reduces the yield and affects the quality of C. pilosula and even generates patulin, threatening human health. In this study, postharvest fresh, healthy C. pilosula was sprayed with P. expansum , and the control effect of ozone on postharvest diseases of C. pilosula was studied, and the effect of ozone on the contents in the main active ingredients of C. pilosula was compared; finally, the effect of ozone on reactive oxygen species (ROS) metabolism in C...
February 20, 2024: Journal of Fungi (Basel, Switzerland)
https://read.qxmd.com/read/38535036/diet-and-lifestyle-intervention-induced-pattern-of-weight-loss-related-to-reduction-in-low-attenuation-coronary-plaque-burden
#7
JOURNAL ARTICLE
Jan Henzel, Mariusz Kruk, Cezary Kępka, Magdalena Makarewicz-Wujec, Łukasz Wardziak, Piotr Trochimiuk, Hubert Krysztofiak, Rafał Dąbrowski, Zofia Dzielińska, Pál Maurovich-Horvat, Marcin Demkow
BACKGROUND: Despite extensive research on body weight and cardiovascular risk, the mechanistic relationship between weight loss and coronary plaque modification has not been adequately addressed. This study aimed to determine the association between body composition dynamics and low-attenuation coronary plaque (LAP) burden. METHODS: Eighty-nine participants (40% women, 60 ± 7.7 years) of the Dietary Intervention to Stop Coronary Atherosclerosis in Computed Tomography (DISCO-CT) study with non-obstructive atherosclerosis with nonobstructive atherosclerosis confirmed in computed tomography angiography (CCTA), a randomized (1:1), prospective, single-center study were included into the analysis...
March 14, 2024: Diagnostics
https://read.qxmd.com/read/38534960/pc-pep-a-comprehensive-daily-six-month-home-based-patient-empowerment-program-leads-to-weight-loss-in-men-with-prostate-cancer-a-secondary-analysis-of-a-clinical-trial
#8
JOURNAL ARTICLE
Wyatt MacNevin, Gabriela Ilie, Ricardo Rendon, Ross Mason, Jesse Spooner, Emily Chedrawe, Nikhilesh Patil, David Bowes, Greg Bailly, David Bell, Derek Wilke, Jeffery B L Zahavich, Cody MacDonald, Robert David Harold Rutledge
Background: The Prostate Cancer-Patient Empowerment Program (PC-PEP) is a six-month daily home-based program shown to improve mental health and urinary function. This secondary analysis explores weight loss in male PC-PEP participants. Methods: In a randomized clinical trial with 128 men undergoing curative prostate cancer (PC) treatment, 66 received 'early' PC-PEP, while 62 were assigned to the 'late' waitlist-control group, receiving 6 months of standard-of-care treatment followed by 6 months of PC-PEP. PC-PEP comprised 182 daily emails with video-based exercise and dietary (predominantly plant-based) education, live online events, and 30 min strength training routines (using body weight and elastic bands)...
March 21, 2024: Current Oncology
https://read.qxmd.com/read/38534581/how-the-crosslinker-amount-influences-the-final-properties-of-hydroxyethyl-methacrylate-cryogels
#9
JOURNAL ARTICLE
Giuseppe Proietto Salanitri, Enrica Luzzi, Daniele Caretti, Tommaso Mecca, Sabrina C Carroccio, Andrea A Scamporrino
The investigation of the mechanical, thermal, and adsorption properties of hydroxyethyl methacrylate (HEMA) cryogels as a function of a reactant ratio is herein reported to better address materials for specific applications. To this aim, cryogels have been synthesized using different monomer/crosslinker (N,N'-methylene-bisacrylamide-MBAA) ratios. The study of SEM images made it possible to identify the trend in the material's macroporosity. As would be expected, the average measured pore width decreased as the amount of MBAA increased while the number of pores grew...
February 22, 2024: Gels
https://read.qxmd.com/read/38534183/what-factors-can-affect-the-occurrence-of-vertigo-in-patients-after-craniofacial-surgery-in-china
#10
JOURNAL ARTICLE
Sainan Zhang, Jun Zhuang, Wenhong Wu, Lan Huang, Mei Tian, Li Guo, Mengjin Sun, Jintian Hu, Na Liu
Vertigo is a complication of craniomaxillofacial contour plastic surgery characterized by dizziness from hypovolemia in the cerebral hemispheres and brainstem. The authors analyzed the current status and influencing factors of postoperative vertigo in patients who undergo craniomaxillofacial contouring and discussed improvements in nursing strategies. The authors investigated 418 patients admitted to the authors' hospital who underwent craniomaxillofacial contouring between November 2020 and October 2023 and divided them into asymptomatic and symptomatic groups based on syncopal precursors or vertigo...
March 27, 2024: Journal of Craniofacial Surgery
https://read.qxmd.com/read/38534167/the-impact-of-weight-loss-programs-on-bmi-trajectory-in-patients-with-metabolic-dysfunction-associated-steatotic-liver-disease-a-veterans-health-administration-study
#11
JOURNAL ARTICLE
Helen Tang, David E Kaplan, Nadim Mahmud
BACKGROUND: Weight loss is the mainstay of management for patients with metabolic dysfunction-associated steatotic liver disease. We studied the impact of referral to MOVE!, a nationally-implemented behavioral weight loss program, on weight in MASLD patients. METHODS: This retrospective cohort study included 102,294 MASLD patients from 125 Veterans Health Administration centers from 2008-2022. RESULTS: Most patients lost no significant weight or gained weight...
March 27, 2024: American Journal of Gastroenterology
https://read.qxmd.com/read/38534127/glucagon-like-peptide-1-receptor-agonists-increase-solid-gastric-residue-rates-on-upper-endoscopy-especially-in-complicated-diabetic-patients-a-case-control-study
#12
JOURNAL ARTICLE
Kevin Garza, Eli Aminpour, Janaki Shah, Bhati Mehta, Dayna Early, C Prakash Gyawali, Vladimir Kushnir
OBJECTIVE: Glucagon-like peptide-1 receptor agonists (GLP-1RA) prescribed for weight loss and type 2 diabetes mellitus (T2DM) can delay gastric emptying but risk factors and impact on procedure outcomes remain unclear. METHODS: We compared frequency of gastric residue on upper endoscopy in patients on a GLP-1RA and propensity-score matched controls in this retrospective case-control study of consecutive patients undergoing endoscopic procedures over a 3.5 year period...
March 27, 2024: American Journal of Gastroenterology
https://read.qxmd.com/read/38533994/mobile-phone-text-messaging-for-medication-adherence-in-secondary-prevention-of-cardiovascular-disease
#13
REVIEW
Julie Redfern, Qiang Tu, Karice Hyun, Matthew A Hollings, Nashid Hafiz, Clara Zwack, Caroline Free, Pablo Perel, Clara K Chow
BACKGROUND: Cardiovascular diseases (CVDs) are the leading cause of death globally, accounting for almost 18 million deaths annually. People with CVDs have a five times greater chance of suffering a recurrent cardiovascular event than people without known CVDs. Although drug interventions have been shown to be cost-effective in reducing the risk of recurrent cardiovascular events, adherence to medication remains suboptimal. As a scalable and cost-effective approach, mobile phone text messaging presents an opportunity to convey health information, deliver electronic reminders, and encourage behaviour change...
March 27, 2024: Cochrane Database of Systematic Reviews
https://read.qxmd.com/read/38533958/associations-of-alcohol-consumption-with-left-atrial-morphology-and-function-in-a-population-at-high-cardiovascular-risk
#14
JOURNAL ARTICLE
Aniqa B Alam, Estefania Toledo-Atucha, Dora Romaguera, Angel M Alonso-Gómez, Miguel A Martínez-Gonzalez, Lucas Tojal-Sierra, Marta Noris Mora, Caterina Mas-Llado, Linzi Li, Ines Gonzalez-Casanova, Jordi Salas-Salvadó, Montserrat Fitó, Alvaro Alonso
BACKGROUND: Excessive alcohol consumption has been associated with increased risk of atrial fibrillation, although the underlying mechanisms remain unclear. An enlarged left atrium and impaired left atrial function may lead to atrial fibrillation. The association of alcohol consumption with structural and functional left atrial measures, however, has received limited attention. METHODS AND RESULTS: We studied 503 participants from the PREDIMED-Plus (Prevención con Dieta Mediterránea) trial, a randomized trial testing intensive weight loss intervention with an energy-reduced Mediterranean diet and physical activity promotion in preventing cardiovascular disease in adults with metabolic syndrome...
March 27, 2024: Journal of the American Heart Association
https://read.qxmd.com/read/38533896/synthesis-of-novel-hydrazide-schiff-bases-with-anti-diabetic-and-anti-hyperlipidemic-effects-in-vitro-in-vivo-and-in-silico-approaches
#15
JOURNAL ARTICLE
Waseem Ul Islam, Abad Khan, Faizullah Khan, Saeed Ullah, Muhammad Waqas, Hammad Khan, Momin Khan, Shaikh Mizanoor Rahman, Shaukat Ali, Abdul Mateen, Asaad Khalid, Ajmal Khan, Ahmed Al-Harrasi
The increasing global incidence of non-insulin-dependent diabetes mellitus (NIDDM) necessitates innovative therapeutic solutions. This study focuses on the design, synthesis and biological evaluation of Schiff base derivatives from 2-bromo-2-(2-chlorophenyl) acetic acid, particularly hydrazone compounds 4a and 4b . Both in-vitro and in-vivo assays demonstrate these derivatives' strong antidiabetic and anti-hyperlipidemic properties. In a 15-d experiment, we administered 4a and 4b at doses of 2.5 and 5 mg/kg body weight, which effectively improved symptoms of alloxan-induced diabetes in mice...
March 27, 2024: Journal of Biomolecular Structure & Dynamics
https://read.qxmd.com/read/38533664/blood-kinetics-of-lipophilic-and-proteinophilic-pollutants-during-two-types-of-long-term-fast-in-king-penguins
#16
JOURNAL ARTICLE
Margaux Mollier, Paco Bustamante, Ignacio Martinez-Alvarez, Quentin Schull, Pierre Labadie, Hélène Budzinski, Yves Cherel, Alice Carravieri
In vertebrates, fasting is an intricate physiological process associated with strong metabolic changes, yet its effect on pollutant residue variation is poorly understood. Here, we quantified long-term changes in plasma concentrations of 20 organochlorine and 16 perfluoroalkyl pollutants in king penguins Aptenodytes patagonicus during the breeding and molting fasts, which are marked by low and high levels of protein catabolism, respectively, and by strong lipid use. The profile of measured pollutants in plasma was dominated by perfluorooctanesulfonic acid (PFOS, initial relative contribution of 60%)...
March 27, 2024: Environmental Science & Technology
https://read.qxmd.com/read/38533552/taar1-agonist-ulotaront-delays-gastric-emptying-of-solids-in-patients-with-schizophrenia-and-concurrent-metabolic-syndrome-with-prediabetes
#17
JOURNAL ARTICLE
Snežana Milanović, Nina Dedic, Robert Lew, Duane Burton, Kenneth S Koblan, Michael Camilleri, Seth C Hopkins
BACKGROUND: Metabolic syndrome (MetS), which can be induced or exacerbated by the current class of antipsychotic drugs, is highly prevalent in patients with schizophrenia and presents significant challenges to lifetime disease management. Supported by initial clinical results, trace amine-associated receptor 1 (TAAR1) agonists have emerged as potential novel treatments for schizophrenia. Notably, non-clinical studies have also shown weight-lowering and glucoregulatory effects of TAAR1 agonists, including the investigational agent ulotaront...
March 27, 2024: Diabetes, Obesity & Metabolism
https://read.qxmd.com/read/38533279/sglt2-inhibitors-paradigm-shift-from-diabetes-care-to-metabolic-care-an-indian-perspective
#18
REVIEW
K M Prasanna Kumar, A G Unnikrishnan, Pankaj Jariwala, Ashwani Mehta, Richa Chaturvedi, Sagar Panchal, Preet Lakhani, Rachana Acharya, Jitendra Dixit
The prevalence and burden of diabetes are on the rise in India, making it 'the diabetes capital of the world'. Comorbidities such as obesity, cardiovascular (CV) complications, chronic kidney disease (CKD), non-alcoholic fatty liver disease (NAFLD), and neurodegenerative diseases are common in patients with diabetes. Recent breakthroughs in diabetes medications and continuous glucose monitoring have resulted in a paradigm shift in diabetes care. Hence, a review in the Indian context is warranted. This review focuses on the existing evidence (gathered by a systematic literature search utilising online databases such as PubMed) on the metabolic, cardio-renoprotective, and hepatoprotective effects of sodium-glucose co-transporter 2 (SGLT2) inhibition, particularly in the Indian setting...
2024: Indian Journal of Endocrinology and Metabolism
https://read.qxmd.com/read/38532941/central-pancreatectomy-balancing-between-the-favorable-functional-results-and-the-increased-associated-morbidity
#19
Dimitrios Symeonidis, Ismini Paraskeva, Athina A Samara, Labrini Kissa, Alexandros Valaroutsos, Eleana Petsa, Konstantinos Tepetes
Introduction  Central pancreatectomy (CP) represents an organ-preserving type of pancreatic resection. The procedure has been associated with improved long-term functional results, but increased postoperative morbidity rates, compared with the more radical resection types. The purpose of the present study was to present the outcomes of three consecutive CPs performed in our department. Materials and Methods  Between January 2021 and January 2022, three patients (A, B, and C) were submitted to a CP in our department...
January 2024: Surgery Journal
https://read.qxmd.com/read/38532850/a-case-report-of-primary-hyperparathyroidism-in-an-adolescent-during-ramadan-fast
#20
Ujunwa Justina Eze, Sundus Elfadil
Primary hyperparathyroidism is rare in children and usually presents with nonspecific symptoms. Ramadan fasting has been reported to unmask the diagnosis of primary hyperparathyroidism. A 15-year-old boy presented to the clinic for an emergency department follow up visit. He had started Ramadan fasting a week before his presentation to the clinic. He reported unintentional weight loss, abdominal pain, constipation, frequent headaches, exercise intolerance, tiredness, and palpitations. Physical examination was unremarkable except that he looked tired...
2024: SAGE Open Medical Case Reports
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